Kuyimitsidwa Augmentin 400 - malangizo ntchito

Augmentin penicillin mankhwala amaloledwa kwa onse akuluakulu ndi ana. Amawerengera matenda ambiri. Koma nthawi zina, amayi achichepere samadikirira kuti adotolo alandire kapena mosemphanitsa, amachita mosemphana nawo, m'malo mwa "Augmentin 400" ndi zomwe adotolo adalamulira. Pankhaniyi, mavuto akhoza kuwuka ndi mlingo woyenera wa kuyimitsidwa kwa Augmentin 400 kwa ana. Kuti musavulaze, koma kuti mupeze phindu lenileni komanso, nthawi zambiri, mankhwala othandiza, muyenera kumvetsetsa zina mwanzeru.

Chithunzi cha kuyimitsidwa "Augmentin 400"

Augmentin 400 imakhazikitsidwa ndi amoxicillin, mankhwala othana ndi chitetezo komanso clavulanic acid omwe amateteza amoxicillin kuti asawonongedwe.

Amoxicillin ndiye chinthu chachikulu cha kuyimitsidwa "Augmentin 400". Ndi iye amene ali ndi bakiteriya komanso antibacterial zotsatira za thupi. Ubwino wa amoxicillin ndikuti umayamba kuzolowera tizilombo tina. Izi zikutanthauza kuti amangosiya kuyamwa mankhwalawo. Apa ndipamene asidi wa clavulanic amayamba. Zimapangitsa ma virus kuti asapume.

Amoxicillin ndi mankhwala othana ndi penicillin gulu motero amaloledwa ngakhale ndi ana aang'ono ndi amayi apakati, kupatula pena pazovuta zina.

Koma kumbukirani kuti, monga mankhwala ambiri, ali ndi zotsatirapo zake. Komanso, imaphatikizidwa mu milandu ya phenylketonuria, komanso kulephera kwa aimpso ndi matenda a chiwindi.

Kuyimitsidwa kwa Augmentin kumaperekedwa kwa matenda osiyanasiyana kupuma, matenda a pakhungu, ndi khungu.

Kuyimitsidwa kwa Augmentin kumathandizanso ndi osteomyelitis. Ndi njira yabwino kwambiri yopatsira matenda opereshoni.

Momwe mungakonzekere kuyimitsidwa "Augmentin" ndi momwe mungatengere:

• Mankhwala ayenera kuthiridwa mu vial ndi kutsanulira madzi owiritsa. Yang'anani! Madzi sakhala otentha,
• Chotsatira, iyenera kugwedezeka bwino, kuti isungunuke kwambiri pazakumwa ndikuchoka kwa mphindi 4. Munthawi imeneyi, ngakhale tinthu tating'onoting'ono kwambiri tidzakhala ndi nthawi yosungunuka.
• Koma ngati mukuwona kuti izi sizinachitike, ndiye kuti gwiranani botolo linalo ndikupatula mphindi zina zisanu.
• Kenako muyenera kuwonjezera madzi pachizindikirocho.
• Pambuyo pa izi, mankhwalawa amatha kuonedwa kuti ali okonzeka kugwiritsidwa ntchito.
• Kuyimitsa komwe kumalizidwa kumatha kusungidwa mufiriji - mpaka masiku 7, koma osawuma. Pambuyo masiku 7, amaletsedwa kugwiritsa ntchito mankhwalawa.

Mukachotsa kuyimitsidwa mufiriji, muyenera kuyisula bwino ndikuthira mulingo woyenera mu supuni yoyezera. Mutha kuyimba kuchuluka kwa mankhwalawo ndi syringe.

Kumbukirani kuti zinthu zonse zomwe mumagwiritsa ntchito ziyenera kusamalidwa bwino. Palibe chifukwa, musalole kuti tinthu ta kuyimitsidwa tiume pa supuni kapena syringe, ndikugwiritsidwa ntchito kangapo osasamba.

Ngati mwana sangamwe kumwa kuyimitsidwa, mwachitsanzo chifukwa chosakoma kwa iye, amaloledwa kuwonjezera madzi. Koma nthawi yomweyo, muyenera kumwa njira zonsezi.

Mlingo wa kuyimitsidwa "Augmentin 400" kwa ana: malangizo a momwe mungadziwerengere nokha

Kukonzekera kwa ufa "Augmentin" kungagulidwe ku malo ogulitsa mankhwala omwe ali ndi mitundu yosiyanasiyana, momwe ammagulu a amoxicillin ndi clavulanic acid ndi osiyana:

• 125 mg ya amoxicillin + 31.35 mg wa clavulanic acid,
• 200 mg ya amoxicillin + 28,5 mg wa clavulanic acid,
• 400 mg ya amoxicillin + 57 mg wa clavulanic acid.

Pazochitika zonse, mlingo waukulu ndi 5 ml ya kuyimitsidwa komwe kwatha. Koma muyenera kudziwa kuti kuwerengera kwa muyezo wa Augmentin 400 kumachitika nthawi zonse malinga ndi kuchuluka kwa amoxicillin: 125, 200 kapena 400. Izi ndizofunikira kumvetsetsa kuti muzikumbukira kuti mankhwalawa sasinthana wina ndi mzake. Ndipo ngati mutapatsidwa "Augmentin 400", simungathe kusintha m'malo mwa "Augmentin 200" kapena "Augmentin 125" komanso mosemphanitsa.

Kuyimitsidwa kwa Augmentin 400 nthawi zambiri kumayendetsedwa kwa ana azaka zopitilira 12 ndi akulu. Kulemera kwa thupi kwa mwana kuyenera kupitirira 40 kg. Koma kutenga ana osaposa zaka 2 ndi zotsutsana. Augmentin ndiwowoyenereradi.

Mlingo wa kuyimitsidwa "Augmentin 400" kwa ana ndi munthu payekha - ndikofunikira kuganizira kulemera kwa thupi, kuopsa kwa matendawa, zaka. Mlingo wawerengedwa kokha kwa amoxicillin.

Ngati mankhwalawa amalembedwa kwa mwana wosakwana zaka 12, ndiye kuti ndi bwino kuonetsetsa kuti kilogalamu imodzi ya kulemera kwa thupi imatulutsa osaposa 45 mg komanso osachepera 25 mg wa antibayotiki.

Kukula kwa matendawo kumathandizanso kwambiri. Mwachitsanzo, ndimatenda a pakhungu, tonsillitis yachilendo - Mlingo wothandizira maantiotic - ndi ochepa. Koma ndi matenda opatsirana pachimake, chibayo, bronchitis - kuchuluka kwa mankhwalawa kumawonjezeka.

Ndikofunika kukumbukira kuti palinso kuchuluka kwa Mlingo wa mankhwalawa. Mwachitsanzo, mwana wosakwana zaka 12 akhoza kupatsidwa 1 pena 2 p. patsiku. Ndipo kupatukana pakati pa mapwando awiriwo kuyenera kukhala osachepera maola 12.

Chitsanzo cha kuwerengera kwa mankhwalawa:

Mwana wazaka 8, kulemera - 27 makilogalamu. Matendawa ndi otitis media. Afunika mankhwalawa 45 mg pa kilogalamu imodzi yolemera. Izi zikutanthauza kuti mulingo wokwanira wa mankhwalawa uzikhala 1215 mg, womwe udzagawidwa pawiri - Mlingo wa 2,5,5 mg uliwonse.

Mu 5 ml ya kuyimitsidwa kwa Augmentin - 400 mg, zomwe zikutanthauza kuti 7.6 ml, kapena 15 ml patsiku, ziyenera kupangidwa nthawi imodzi.

Sizovuta kwambiri kuwerengera kuchuluka kwa kuyimitsidwa kwa Augmentin 400 kwa mwana. Popeza muyenera kuchita masamu. Nthawi zambiri, makolo amasokonezedwa mwa iwo, motero pamakhala mfundo zomwe amayendera. Koma ndikwabwino kugwiritsa ntchito izi ngati malingaliro. Ndiye kuti, muwone ngati mawerengeredwewo akulondola.

Mwachitsanzo, mwana wosaposa chaka chimodzi ndipo wolemera mpaka 18 makilogalamu sayenera kupitirira 5 ml ya kuyimitsidwa koyimitsidwa "Augmentin". Mwana wamkulu wazaka zopitilira 6 kuchokera pa 19 kg atha kukhala ndi kuyimitsidwa kolimba 7.5 kale. Ngati mwana ali kale ndi zaka 10, ndipo akulemera kuposa 29 makilogalamu, ndiye kuti akufunika 10 ml ya kuyimitsidwa nthawi. Koma mfundo izi siziganizira matendawa, ngakhale kuuma kwake.

Kuyimitsidwa Augmentin: ndemanga za ogula

Monga maantibayotiki onse, Augmentin 400 ili ndi zovuta zina. Ndemanga za iye kuchokera kwa makolo ndizotsutsana. Koma muyenera kumvetsetsa kuti maantibayotiki amayenera kumwedwa pokhapokha ngati akuwuzani dokotala komanso pokhapokha ngati simungathe popanda iwo.

Irina: "Timagwiritsa ntchito Augmentin kuyimitsidwa kwa bronchitis. Tsoka ilo, njira zina sizithandiza. Koma timayesetsa kuzigwiritsa ntchito limodzi ndi njira zina. Mwanayo ali ndi zaka zitatu. Mankhwala pawokha amatengedwa masiku 4, kamodzi patsiku, 5 ml. Onetsetsani kuti mwabwezeretsa microflora yam'mimba pambuyo pake. "

Olesya: "Dokotala wa ana anatiumiriza kuti tigule mankhwalawa -" Augmentin "tikadzapatsidwa upangiri wokhudza matendawa. Kwa mwana wamwamuna - 6 l. Adalamulira 5 ml ya kuyimitsidwa tsiku lililonse kwa masiku 7 motsatizana. Ndidaganiza kuti uyu ndi katswiri, chifukwa chake ayenera kudalira ndikuyesera kutsatira momveka bwino malangizowo. Koma atatha kudya koyamba, mwana adayamba kusanza, ndipo pambuyo pake wachiwiri adayamba kusanza. Tachotsa mankhwalawo. Zidakhala zabwino zomwe zimachitika pafupipafupi. ”

Augmentin si mankhwala otetezeka. Maantibiotic siotetezeka ndipo ali ndi zotsutsana ndi zoyipa zomwe zimafunikira kuganiziridwa.

Chifukwa chake, onetsetsani kuti mumwa mankhwalawo pokhapokha mutapita kwa dokotala ndi malingaliro ake ndikukhala osamala kwambiri.

Mtengo woyimirira wa kuyimitsidwa "Augmentin 400" ndi pafupifupi 380-460 rubles. Mwachidziwikire, mutha kudziwa mu malo ogulitsa mankhwala mumzinda wanu.

Zotsatira za pharmacological

Augmentin ndi anti-virus wambiri. The yogwira zinthu za mankhwala amathandizira zotsatirazi pharmacological zotsatira:

• Amoxicillin ndi mankhwala osokoneza bongo ochepa omwe amagwiritsidwa ntchito polimbana ndi tizilombo toyambitsa matenda a gramu-gramu komanso gram. Kuwonekera pang'onopang'ono kwa amoxicillin sikufikira ku tizilombo tating'onoting'ono timene timatulutsa enzyme ya beta-lactamase.
• Clavulanic acid imakhudzanso beta-lactamases komanso imateteza amoxicillin kuti isawonongedwe musanakwane ndi ma enzymes awa. Izi zimakuthandizani kuti muwonjezere antibacterial zotsatira za amoxicillin.

Tizilombo tating'onoting'ono tomwe timayang'ana pakuphatikizidwa kwa amoxicillin + clavulanic acid:

• Mabakiteriya a grob-aerobic olimba: bacilli, fecal enterococci, listeria, nocardia, streptococcal ndi staphylococcal.
• Mabakiteriya a anaerobic a gram-positive: clostidia, peptostreptococcus, peptococcus.
• Bakiteriya wa a grob-aerobic: wambiri chifuwa, Helicobacter pylori, hemophilic bacilli, cholera vibrios, gonococci.
• Tizilombo toyambitsa matenda a grram-hasi anaerobic: matenda a clostridial, bacteroids.

Zizindikiro zogwiritsidwa ntchito

Chizindikiro chotenga Augmentin ndi chithandizo cha matenda oyambitsidwa ndi bakiteriya omwe amayamba chifukwa cha tizilombo tating'onoting'ono tomwe timayang'ana mbali za mankhwalawa. Zovuta za matenda otsatirawa:

• Matenda a ziwalo za ENT, mwachitsanzo, tenillillitis, sinusitis, media atitis, omwe nthawi zambiri amayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhal ndi Streptococcus pyogene.
• Matenda ochepetsa kupuma am'mimba, monga kufalikira kwa chifuwa cham'mimba, chibayo, ndi bronchopneumonia, omwe amayamba chifukwa cha Streptococcus pneumoniae, Haemophilus fuluwenza, ndi Moraxella catarrhalis.
• Matenda a urogenital thirakiti, monga cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli), Staphylococcus saprophyticus ndi mitundu ya genus Enterococcus, komanso gonorrhea yoyambitsidwa ndi Neisseria gonorrhoeae.
• Matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus, Streptococcus pyogene, ndi mitundu ya mtundu wa Bacteroides.
• Matenda a mafupa ndi mafupa, monga osteomyelitis, omwe nthawi zambiri amayamba chifukwa cha Staphylococcus aureus, ngati chithandizo cha nthawi yayitali chikufunika.
• Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Augmentin®, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira.

Mphamvu ya tizilombo tosiyanasiyana to Augmentin itha kusiyanasiyana kutengera malo omwe wodwalayo amakhala. Ngati izi ndizotheka, ndiye kuti mukafufuza ndikofunikira kuganizira ziwerengero zam'deralo pakumvetsetsa kwa tizilombo tating'onoting'ono.

Ngati ndi kotheka, wodwalayo amayenera kuyesedwa kuti adziwe zamtunduwu wa antigen Augmentin.

"Augmentin": mawonekedwe a mankhwala

Zigawo zikuluzikulu za Augmentin, mosasamala kanthu za mtundu wake wa kutulutsidwa kwake, ndi mankhwala amoxicillin othandizira ndi lactamase kuthetsa, clavulline acid. Cholemetsa chachikulu chagona ndi amoxicillin: ndikuthokoza kuti mankhwalawa ali ndi antibacterial motsutsana ndi matenda aliwonse. Komabe, ili ndi vuto lalikulu - tizilombo tating'onoting'ono tambiri timazolowera ndikuleka kuyankha, chifukwa chomwe gawo lina likufunika lomwe lingathe kuthana ndi ma virus. Ichi ndi clavulline acid.

• Amoxicillin ndi gawo limodzi la gulu la penicillin ndipo, nthawi zambiri, limalekeredwa bwino, chifukwa chomwe lingagwiritsidwe ntchito pochiza ana ndi amayi apakati, komabe, ili ndi zovuta zingapo. Kuphatikiza apo, sivomerezedwa kuti agwiritsidwe ntchito kwa odwala omwe ali ndi phenylketonuria, kulephera kwaimpso komanso kuwonongeka kwa chiwindi.

Zizindikiro zazikulu zothandizira kuyimitsidwa kwa Augmentin ndi:

• Matenda opatsirana am'mapapo thirakiti mwanjira iliyonse, kuphatikizapo kuyambiranso kwa matenda osakhazikika,
• Matenda opatsirana a genitourinary system,
• Matenda a pakhungu oyambitsidwa ndi matenda
• Osteomyelitis
• Kupewa matenda opereshoni.

Kulandila kuyimitsidwa "Augmentin" zakonzedwa molingana ndi algorithm otsatirawa:

• Ufa umathiridwa m'botolo, kenako umathiridwa ndi madzi otentha (osatentha!), Omwe amayenera kuwiritsa pambuyo pake,
• Botolo limagwedezeka kuti magawo amatha kusungunuka momwe angathere, ndikuyika mphindi 4-5. mpaka zigawo za chinthucho zitasungunuka kwathunthu. Izi zikapanda kuchitika, botilo liyenera kugwedezekanso ndikuyika pambali,
• Onjezerani madzi pachiwopsezo mkati mwa vial,
• Pambuyo pa izi, kuyimitsidwa kwakonzeka kugwiritsidwa ntchito. Itha kusungidwa kuzizira, ngati sikuzizira, kwa masiku 7, koma ndikulimbikitsidwa kuti muzigwiritsa ntchito nthawi yochepa. Ndi zoletsedwa kugwiritsa ntchito kuyimitsidwa pa tsiku la 8, ngakhale zowoneka sizinasinthe malo ake.
• Musanagwiritse ntchito, bokosi lamadzi limagwedezeka, ndipo voliyumu yofunika imaponyedwa supuni yoyezera kapena yodzazidwa ndi syringe. Mukatha kugwiritsa ntchito, ndikofunikira kutsuka chilichonse mwazinthuzo, kupewa kupewa kuchuluka kwa mankhwalawa pansi,
• Ngati ndi kotheka, amaloledwa kuthira madziwo ndi madzi otentha owiritsa mulingo wofanana, komabe, mwana adzamwa kuchuluka kokwanira, osati theka lake,

Mtengo woyerekeza wa kuyimitsidwa "Augmentin 400" umachokera ku 380-460 rubles.

Mlingo

Ufa woyimitsidwa pakamwa 400 mg / 57 mg / 5 ml, 35 ml

5 ml ya kuyimitsidwa kuli

ntchito: amoxicillin (monga amoxicillin trihydrate) 400 mg,

clavulanic acid (monga potaziyamu clavulanate) 57 mg,

zokopa: xanthan chingamu, asipirame, anhydrous colloidal silicon dioxide, magnesium stearate, crospovidone, croscarmellose sodium, senzo benzoate, sitiroberi flavored, anhydrous silicon dioxide.

Ufa wa mtundu oyera kapena pafupifupi woyera ndi tinthu tachikasu, wokhala ndi fungo labwino. Kuyimitsidwa kokhazikikaku ndi koyera kapena pafupifupi kuyera, poyimirira, kutulutsa koyera kapena pafupifupi koyera kumapangika pang'ono.

Mankhwala

Farmakokinetics

Amoxicillin ndi clavulanate amasungunuka bwino pamankhwala amadzimadzi ndi pH yachilengedwe, mwachangu komanso yokwanira kuchokera m'matumbo am'mimba atatha kukonzekera pakamwa. Mafuta a amoxicillin ndi clavulanic acid ndi bwino akamwa mankhwalawa koyambirira kwa chakudya. Mutatha kumwa mankhwalawo mkati, kuphatikiza kwake ndi 70%. Mbiri ya zigawo zonse ziwiri za mankhwalawa ndi ofanana ndipo imafika pachimake cha plasma (Tmax) pafupifupi ola limodzi. Magetsi a amoxicillin ndi clavulanic acid mu seramu yamagazi ndi ofanana onse pakakhala ntchito ya amoxicillin ndi clavulanic acid, ndipo gawo lililonse limasiyanitsidwa.

Zochizira zozama amo amoillillin ndi clavulanic acid zimatheka zosiyanasiyana ziwalo ndi minofu, interstitial madzimadzi (mapapu, m'mimba, chikhodzodzo ndulu, adipose, mafupa ndi minofu minofu, pleural, synovial ndi peritoneal zamadzimadzi, khungu, bile, purulent zotupa, sputum). Amoxicillin ndi clavulanic acid mothandizidwa samalowa mu madzi a cerebrospinal.

Kumangiriza kwa amoxicillin ndi clavulanic acid kuma protein a plasma ndizochepa: 25% ya clavulanic acid ndi 18% ya amoxicillin. Amoxicillin, monga ma penicillin ambiri, amathandizidwa mkaka wa m'mawere. Zotsatira za clavulanic acid zapezekanso mkaka wa m'mawere. Kupatula kupezeka kwa chiwopsezo cha kukhudzidwa, amoxicillin ndi clavulanic acid sizimawononga thanzi la ana akhanda omwe akuyamwa. Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.

Amoxicillin amachotseredwa makamaka ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso ndi owonjezera. Pambuyo pakamwa limodzi lokha piritsi limodzi la 250 mg / 125 mg kapena 500 mg / 125 mg, pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa mu mkodzo m'maola 6 oyamba.

Amoxicillin amapukusidwa pang'ono mu mkodzo wofanana ndi penicillinic acid wofanana ndi 10-25% ya mankhwalawa. Clavulanic acid m'thupi imapangidwa mochuluka kuti 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxy-butan-2-amodzi ndipo amachotsedwa. ndi mkodzo ndi ndowe, komanso mawonekedwe a mpweya woipa kudzera mumlengalenga.

Mankhwala

Augmentin® ndi mankhwala ophatikiza okhala ndi amoxicillin ndi clavulanic acid, omwe ali ndi zochita zambiri za bactericidal, osagwirizana ndi beta-lactamase.

Amoxicillin ndi mankhwala osokoneza bongo omwe amapanga motsutsana ndi michere yambiri yama gramu ndi gram-negative. Amoxicillin amawonongedwa ndi beta-lactamase ndipo samakhudza tizilombo tating'onoting'ono timene timatulutsa enzyme iyi. Limagwirira a amoxicillin ndikulephera biosynthesis wa peptidoglycans wa bakiteriya cell khoma, zomwe nthawi zambiri zimayambitsa lysis ndi cell kufa.

Clavulanic acid ndi beta-lactamate, yofanananso ndi mankhwala opangidwa ndi penicillin, omwe amatha kuphatikiza ma enzymes a beta-lactamase omwe amaletsa penicillin ndi cephalosporins, potero amateteza kutha kwa amoxicillin. Ma Beta-lactamases amapangidwa ndi mabakiteriya ambiri opanda gramu komanso gram-negative. Kuchita kwa beta-lactamases kumatha kubweretsa kuwonongeka kwa mankhwala ena a antibacterial ngakhale asanayambe kukhudza tizilombo toyambitsa matenda. Clavulanic acid imalepheretsa ma enzymes, kubwezeretsa chidwi cha mabakiteriya ku amoxicillin. Makamaka, imakhala ndi ntchito yayikulu yolimbana ndi plasmid beta-lactamases, yomwe mankhwala osokoneza bongo amakhudzidwa nthawi zambiri, koma osagwira motsutsana ndi mtundu wa 1 chromosomal beta-lactamases.

Kupezeka kwa clavulanic acid ku Augmentin® kumateteza amoxicillin ku zowonongeka za beta-lactamases ndikukulitsa mawonekedwe ake a zochita za antibacterial ndikuphatikizidwa kwa ma cellorganices omwe nthawi zambiri amakhala osagwirizana ndi penicillin ena ndi cephalosporins. Clavulanic acid okhala ngati mankhwala amodzi alibe mphamvu zambiri za antibacterial.

Njira yokana kukana

Pali njira ziwiri zoyambitsira kukana kwa Augmentin ®

- inactivation ndi bakiteriya-mabakiteriya, omwe samazindikira zotsatira za clavulanic acid, kuphatikizapo magulu B, C, D

- Kusintha kwa mapuloteni omanga a penicillin, omwe amachititsa kuchepa kwa mgwirizano wa antioxotic pokhudzana ndi microorganism

Kukhazikika kwa khoma la mabakiteriya, komanso njira zopopera, zimatha kuyambitsa kapena kuthandizira kukulitsa kukana, makamaka pamagalamu opanda tizilombo.

Augmentin®ali ndi bactericidal pa zotsatirazi tizilombo:

Zoyipa zamagalamu: Enterococcus faecalis,Gardnerella vaginalis,Staphylococcus aureus (tcheru ndi methicillin), coagulase-negative staphylococci (woganizira methicillin), Streptococcus agalactiae,Streptococcus pneumoniae1,Streptococcus pyogene ndi ena beta hemolytic streptococci, gulu Streptococcus viridans,Bacillius anthracis, Listeria monocytogene, Nocardia asteroides

Ma grram-negative: Chizimbamangochita,Kapnocytophagaspp.,Eikenellacorrodens,Haemophilusfuluwenza,Mwanaxellachibimanga,Neisseriamichere,Pasteurellamultocida

tizilombo toyambitsa matenda: Bacteroides fragilis,Fusobacterium nucleatum,Prevotella spp.

Ma tizilombo tating'onoting'ono tomwe titha kupezeka nawo

Zoyipa zamagalamu: Enterococcusfaecium*

Ma tizilombo okhala ndi chilengedwe:

gram alibeaerobes:Acinetobactermitundu,Choprobacterfreundii,Enterobactermitundu,Legionella pneumophila, Morganella morganii, Providenciamitundu, Pseudomonasmitundu, Serratiamitundu, Stenotrophomonas maltophilia,

ena:Chlamydia trachomatis,Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.

*Zomverera mwachilengedwe pakakhala zopanda kukana

1 zopatula Streptococcus pneumoniaepenicillin

Mlingo ndi makonzedwe

Kuyimitsidwa kwamakonzedwe a pakamwa kumapangidwira kuti azigwiritsa ntchito ana.

Kuzindikira kwa Augmentin ® kumatha kusiyanasiyana ndi malo ndi nthawi. Musanafotokozere mankhwala, ngati kuli kotheka ndikofunikira kuwunika momwe matulukidwewo alili molingana ndi deta yakumaloko ndikuzindikira zamverazo ndikusanthula zitsanzo kuchokera kwa wodwala wina, makamaka ngati akudwala kwambiri.

Mlingo wa mankhwalawa umakhazikitsidwa payokha kutengera zaka, kulemera kwa thupi, impso, matenda othandizira, komanso kuopsa kwa matendawa.

Augmentin® ndikulimbikitsidwa kuti idatenge kumayambiriro kwa chakudya. Kutalika kwa mankhwalawa kumatengera wodwala momwe amathandizira. Ma pathologies ena (makamaka, osteomyelitis) angafunike nthawi yayitali. Kuchiza sikuyenera kupitilizidwa kwa masiku opitilira 14 popanda kuonanso momwe wodwalayo alili. Ngati ndi kotheka, ntha kuchita njira ya mankhwala (yoyamba, intravenous makonzedwe a mankhwala ndikusinthira kwamkamwa makonzedwe).

Ana kuyambira miyezi iwiri mpaka zaka 12 kapena masekeli osakwana 40

Mlingo, kutengera zaka ndi kulemera kwake, umawonetsedwa mu mg / kg pa thupi patsiku kapena mamililita a kuyimitsidwa kumene.

Mlingo woyenera:

- kuyambira 25 mg / 3.6 mg / kg / tsiku mpaka 45 mg / 6.4 mg / kg / tsiku, logawidwa mu 2 Mlingo, chifukwa cha matenda ofatsa komanso olimbitsa thupi (obwereza matani, khungu ndi minofu yofewa)

- kuchokera pa 45 mg / 6.4 mg / kg / tsiku mpaka 70 mg / 10 mg / kg / tsiku, logawidwa mu 2 Mlingo, pochizira matenda oopsa (otitis media, sinusitis, matenda am'munsi opatsirana thirakiti).

Augmentin single piritsi limodzi lokha kusankha malingana ndi kulemera kwa thupi

Malamulo pokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba.

Pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afundire kutentha ayenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti mutsimikizire kuchepetsedwa kwathunthu. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 92 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa.

Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa mankhwalawa a Augmentin akhoza kuchepetsedwa pakati ndi madzi.

Zithunzi za 3D

1 Popanga mankhwalawa, potaziyamu clavulanate amagona ndi 5% yowonjezera.

1 Madzi oyeretsedwa amachotsedwa nthawi yovala filimu.

Gwiritsani ntchito pa nthawi yoyembekezera

Augmentin angagwiritsidwe ntchito ndi amayi panthawi yomwe akubala mwana milandu yomwe cholinga chake chimapindulitsa kwa mayi kuposa chiopsezo cha mwana wosabadwayo.

Augmentin angagwiritsidwe ntchito poyamwitsa. Zikachitika kuti kumwa mankhwalawo kumathandizira kuti pakhale zovuta zina mwa mwana, nkhani yosiya kuyamwitsa iyenera kuganiziridwa.

Zotsatira zoyipa

Augmentin angathandizire kukulitsa zoyipa zosafunikira izi:

• Candidiasis a mucous nembanemba ndi khungu.
• Kutsegula m'mimba, kunyansidwa komanso kusanza.
• Mutu, chizungulire.
• Khungu loyera, urticaria, zotupa.

Ndi chitukuko cha thupi lawo siligwirizana, mankhwalawa Augmentin yomweyo anasiya.

Ndikofunikira kudziwitsa dokotala za zomwe zimapangitsa kuti mukhale ndi zotsatirapo zoyipa kuti muthe kusintha kapena kusankhira mtundu wa mankhwala.

Bongo

Ngati bongo, kukula kwa osafunika mbali kuchokera m'mimba thirakiti ndi kusokonezeka mu madzi-electrolyte bwino n`zotheka. The mwayi wokhala ndi kulumala kwa odwala ndi mkhutu yachilengedwe kugwira ntchito kwa impso ndi anthu amene analandira mlingo waukulu wa mankhwala ukuwonjezeka.

Mu nkhani ya bongo, muyenera kufunsa dokotala nthawi yomweyo kuti mupeze njira yochizira yodziwitsa matenda omwe amathandizira kugwiranso ntchito kwa m'mimba thirakiti ndi kubwezeretsani mulingo wamagetsi. Zogwira ntchito za Augmentin zimapukusidwa kudzera mu njira ya hemodialysis.

Kuyanjana kwa mankhwala osokoneza bongo

Kugwiritsa ntchito munthawi yomweyo mankhwala a Augmentin ndi phenenecid osavomerezeka. Probenecid imachepetsa katulutsidwe katulutsidwe ka amoxicillin, chifukwa chake munthawi yomweyo kugwiritsa ntchito mankhwala a Augmentin ndi phenenecid kungayambitse kuchuluka kwa magazi ndi kuzungulira kwa amoxicillin, koma osati clavulanic acid.

Kugwiritsa ntchito munthawi yomweyo allopurinol ndi amoxicillin kungakulitse chiopsezo cha khungu losokonezeka. Pakadali pano, palibe zambiri m'mabuku zomwe zimagwiritsidwa ntchito nthawi imodzi yophatikizira amoxicillin ndi clavulanic acid ndi allopurinol. Ma penicillin amatha kuchepetsa mayankho a methotrexate m'thupi mwa kuletsa kubisalira kwake, kotero kugwiritsa ntchito nthawi imodzi ndi gawo la Augmentin ndi methotrexate kungakulitse kuchuluka kwa methotrexate.

Monga mankhwala ena a antibacterial, mankhwalawa Augmentin amatha kukhudza matumbo a microclora, zomwe zimayambitsa kuchepa kwa mayamwidwe a estrogen kuchokera m'matumbo am'mimba komanso kuchepa kwa magwiridwe antchito opatsirana pakamwa.

Malangizo owonjezera

Asanayambe kugwiritsa ntchito Augmentin, wodwala wodwalayo ayenera kudziwa zomwe zimachitika mu penicillin, cephalosporin ndi zina.

Kuyimitsidwa kwa Augmentin kumatha kusokoneza mano a wodwalayo. Popewa kukula kwa zoterezi, ndikokwanira kutsatira malamulo oyambira aukhondo - kupukuta mano, kugwiritsa ntchito misempha.

Kuvomerezedwa Augmentin kungayambitse chizungulire, kotero, pakakhala nthawi yayitali, sayenera kuyendetsa magalimoto ndikuchita ntchito yomwe imafuna chidwi chachikulu.

Augmentin sangagwiritsidwe ntchito ngati mtundu wopatsirana wa mononucleosis ukayikiridwa.

Augmentin amakhala wololera bwino komanso wowopsa. Ngati kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, ndikofunikira kuti muwone momwe impso ndi chiwindi zimagwirira ntchito.

Kufotokozera za mtundu wa kipimo

Mphamvu: yoyera kapena pafupifupi yoyera, yokhala ndi fungo labwino. Ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi koyera kumapangidwa. Poimirira, yoyera kapena yoyera imayamba pang'onopang'ono.

Mapiritsi, 250 mg + 125 mg: yokutidwa ndi nembanemba wa filimu kuyambira yoyera mpaka pafupi yoyera, yopanda mawonekedwe, yolembedwa "AUGMENTIN" mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Mapiritsi, 500 mg + 125 mg: yokutidwa ndi chithunzi cha filimu kuyambira yoyera mpaka pafupifupi yoyera, chowongolera, cholembedwa "AC" ndikuyika pachiwopsezo mbali imodzi.

Mapiritsi, 875 mg + 125 mg: wokutidwa ndi filimu yolimba kuyambira yoyera mpaka yoyera, yoloweka mawonekedwe, yokhala ndi zilembo "A" ndi "C" mbali zonse ndi mzere wolakwika mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Mankhwala

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin amatha kuwonongedwa ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira tizilombo tomwe timatulutsa timadzi tambiri.

Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid imagwira mokwanira motsutsana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukana kwa bakiteriya, ndipo imagwira ntchito kwambiri motsutsana ndi chromosomal beta-lactamases a mtundu woyamba, omwe saletsedwa ndi clavulanic acid.

Kupezeka kwa clavulanic acid mu Augmentin ® kukonzekera kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Otsatirawa ndi ntchito yophatikiza ya amoxicillin ndi clavulanic acid mu vitro .

Bacteria imakonda kuphatikizidwa ndi amoxicillin ndi clavulanic acid

Zoyipa zamagalamu: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia astero> kuphatikiza Streptococcus pyogenes 1.2, Streptococcus agalactiae 1.2 (beta hemolytic streptococci) 1,2, Staphylococcus aureus (yokhudza methicillin) 1, Staphylococcus saprophyticus (tcheru ndi methicillin), coagulase-negative staphylococci (woganizira methicillin).

Zoyipa zaramram: Clostr> kuphatikiza Peptostreptococcus magnus, Peptostreptococcus micros.

Ma grram-negative: Bordetella pertussis, Haemophilus fuluwenza 1, Helicobacter pylori, Moraxella cafarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Ma gram alibe ana Bactero> kuphatikiza Bactero> kuphatikiza Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Zina: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Bacteria yomwe idayamba kukana kuphatikiza amoxicillin ndi clavulanic acid ndiyotheka

Ma grram-negative: Escherichia coli 1, Klebsiella spp., kuphatikiza Klebsiella oxetoca, Klebsiella pneumoniae 1, Proteus spp., kuphatikiza Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Zoyipa zamagalamu: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2 gulu la streptococcus Viridans.

Bacteria yomwe imagwirizana mwachilengedwe pakuphatikizidwa kwa amoxicillin ndi clavulanic acid

Ma grram-negative: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

Zina: Chlamydia spp., kuphatikizapo Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Kwa mabakiteriya awa, kufunikira kwakanthawi kothandizirana kwa amoxicillin ndi clavulanic acid kwawonetsedwa mu maphunziro azachipatala.

2 Zovuta za mitundu iyi ya mabakiteriya sizitulutsa beta-lactamase. Kuzindikira ndi amoxicillin monotherapy kumasonyezanso chidwi chofanana ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Pharmacokinetics

Zosakaniza zonse ziwiri za kukonzekera kwa Augmentin ® - amoxicillin ndi clavulanic acid - zimatengedwa mwachangu komanso mokwanira kuchokera m'mimba kuchokera pakamwa. Kuyamwa kwa yogwira mankhwala a Augmentin ® ndi mulingo woyenera kumwa mankhwala kumayambiriro kwa chakudya.

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga 40 mg + 10 mg / kg / tsiku la mankhwalawa Augmentin ® pamiyeso itatu, ufa woyimitsidwa pakamwa. 125 mg + 31.25 mg mu 5 ml (156.25 mg).

Magawo a pharmacokinetic oyambira

Amoxicillin

Augmentin ®, 125 mg + 31.25 mg mu 5 ml

Clavulanic acid

Augmentin ®, 125 mg + 31.25 mg mu 5 ml