Glucophage hypoglycemic: mphamvu zambiri zotenga pakati pa nthawi yomwe akukonzekera komanso pakukonzekera

Mawonekedwe amankhwala matenda owopsa komanso osachiritsika,

Kuchita opaleshoni yayikulu ndikuvulaza (chithandizo cha insulin chikusonyeza)

Kuchepa kwa chiwindi,

Uchidakwa wambiri ndi poyizoni wa ethanol,

Lactic acidosis (kuphatikiza

Nthawi zosachepera masiku awiri asanafike komanso mkati mwa masiku awiri mutachita maphunziro a radioisotope kapena x-ray ndikuyambitsa ntchito zotsutsana ndi ayodini.

Kutsatira zakudya zamafuta ochepa (

Kuchepetsa (kuyamwitsa),

Hypersensitivity pamagawo a mankhwala.

kugwira ntchito molimbika.

Malangizo apadera

Wodwalayo ayenera kuchenjezedwa za kufunika kosiya kumwa mankhwalawo ndikuwonana ndi dokotala ngati kusanza, kupweteka kwam'mimba, kupweteka kwa minofu, kufooka kwapafupipafupi ndi kuonekera kwambiri. Zizindikiro izi zitha kukhala chizindikiro cha kulowerera lactic acidosis.

Popeza metformin imachotsedwa mu mkodzo, milingo ya serum creatinine iyenera kutsimikizika musanayambe chithandizo ndi mankhwalawa komanso pafupipafupi.

Kusamala makamaka kuyenera kuchitika ngati vuto laimpso likuwonekera, mwachitsanzo, munthawi ya chithandizo cha antihypertensive mankhwala, okodzetsa, NSAIDs.

Mudziwitse wodwalayo za kufunika kofunsa dokotala ngati zikuoneka kuti muli ndi matenda a bronchopulmonary kapena matenda opatsirana a ziwalo zoberekera.

Potengera momwe mankhwalawa amagwiritsidwira ntchito Glucofage®, munthu ayenera kupewa kumwa mowa.

Kugwiritsa Ntchito Kwa Ana

Mwa ana opitirira zaka 10, Glucofage ® ikhoza kugwiritsidwa ntchito limodzi mu monotherapy komanso kuphatikiza ndi insulin.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Monotherapy yokhala ndi Glucofage ® siyimayambitsa hypoglycemia chifukwa chake sichikhudza kuyendetsa galimoto ndikugwira ntchito ndi makina. Komabe, odwala ayenera kusamala za chiopsezo cha hypoglycemia mukamagwiritsa ntchito metformin molumikizana ndi othandizira ena a hypoglycemic (kuphatikizapo zotumphukira za sulfonylurea, insulin, repaglinide).

Nambala zolembetsa

tabu. zokutira filimu, 850 mg: 30, 60 kapena 100 ma PC. P N014600 / 01 (2013-08-08 - 0000-00-00) tabu. zokutira filimu, 1000 mg: 30, 45, 50, 60 kapena 120 ma PC. P N014600 / 01 (2013-08-08 - 0000-00-00) tabu. zokutira filimu, 500 mg: 30, 50, 60 kapena 100 ma PC. P N014600 / 01 (2013-08-08 - 0000-00-00)

Glucophage: malangizo ogwiritsa ntchito ndi kuwunikira

Glucophage ndi mankhwala okhala ndi hypoglycemic effect.

Kutulutsa mawonekedwe ndi kapangidwe kake

Glucophage amapangidwa monga mapiritsi:

• 500 kapena 850 mg: filimu yokutira, yoyera, biconvex, yozungulira, yopingasa - yoyera yoyera (500 mg: ma PC 10. M'matumba, matuza atatu kapena asanu mumakatoni, ma 15 ma PC. 2 kapena matuza mu bokosi la makatoni, ma PC 20. M'matumba, matuza atatu kapena asanu pamakatoni, 850 mg: ma PC 15. M'matumba, matuza awiri kapena anayi mu bokosi la makatoni, ma PC 20. 3 kapena matuza 5
• 1000 mg: yokutidwa ndi filimu, yoyera, biconvex, chowulungika, chokhala ndi notch mbali zonse ziwiri ndi cholembedwa "1000" mbali imodzi, gawo lamtundu wa yunifolomu yoyera (zidutswa 10 m'matuza, 3, 5, 6 kapena Zotulutsa 12 pamatoni okhala ndi makatoni, ma PC 15. M'matumba, matuza 2, 3 kapena 4 mu mtolo wa makatoni).

Piritsi limodzi lili ndi:

• Mphamvu yogwira: metformin hydrochloride - 500, 850 kapena 1000 mg,
• Zothandiza zothandizirana (motengera): povidone - 20/34/40 mg, magnesium stearate - 5 / 8.5 / 10 mg.

Zomwe zimapangidwa ndi chipolopolo:

• 500 ndi 850 mg mapiritsi (motero): hypromellose - 4 / 6.8 mg,
• Mapiritsi a 1000 mg: opadray oyera (macrogol 400 - 4.55%, hypromellose - 90.9%, macrogol 8000 - 4.55%) - 21 mg.

Mankhwala

Metformin imachepetsa mawonetseredwe a hyperglycemia, poletsa kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, mankhwalawa sathandizira kupanga insulin mthupi ndipo silikhala ndi vuto la thanzi. Metformin imachepetsa chidwi cha zotumphukira zolandilira ku insulin ndikuthandizira kugwiritsika ntchito kwa glucose m'maselo, komanso imalepheretsa kaphatikizidwe ka glucose pachiwindi chifukwa choletsa glycogenolysis ndi gluconeogeneis. Vutoli limachepetsa kuyamwa kwa shuga m'matumbo.

Metformin imayendetsa kaphatikizidwe ka glycogen pochita glycogen synthase ndikuwonjezera kuthekera kwamtundu uliwonse wamtundu wa glucose omata. Amakhudzanso kukonzekera kwa lipid metabolism, kuchepetsa kuchuluka kwa triglycerides, otsika osalimba lipoprotein ndi cholesterol yonse.

Poyerekeza ndi momwe chithandizo cha Glucofage chilili, thupi la wodwalayo mwina limakhalabe lokha kapena limachepetsedwa pang'ono.

Kafukufuku wachipatala amatsimikizira mphamvu ya mankhwalawa popewa matenda ashuga odwala matenda ashuga omwe ali ndi chiwopsezo chowonjezereka cha chitukuko cha matenda amtundu wa 2 ngati njira yomwe yasinthidwa sikutsimikizira kuti matendawa ndi olondola.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, Glucophage ndi mankhwala a matenda a shuga 2, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso chifukwa chosakwanira zolimbitsa thupi ndi mankhwala:

• Akuluakulu: monga monotherapy kapena munthawi yomweyo ndi mankhwala ena amkamwa a hypoglycemic kapena ndi insulin,
• Ana ochokera zaka 10: monotherapy kapena munthawi yomweyo ndi insulin.

Malangizo ogwiritsira ntchito Glucofage: njira ndi mlingo

Glucophage iyenera kutengedwa pakamwa.

Kwa akulu, mankhwalawa angagwiritsidwe ntchito ngati monotherapy kapena munthawi yomweyo ndi mankhwala ena a pakamwa a hypoglycemic.

Kumayambiriro kwa chithandizo, Glucofage 500 kapena 850 mg nthawi zambiri imayikidwa. Mankhwalawa amatengedwa katatu patsiku ndi chakudya kapena akangomaliza kudya. Kutengera kuchuluka kwa shuga m'magazi, kuwonjezereka kwapang'onopang'ono kwa mlingo kumatheka.

Njira yokonzanso tsiku lililonse la Glucofage nthawi zambiri imakhala 1,500-2,000 mg (pazipita 3,000 mg). Kumwa mankhwalawa katatu patsiku kumachepetsa kuopsa kwa mavuto am'mimba. Komanso, kuwonjezeka kwapang'onopang'ono kwa mlingo kungapangitse kusintha kwa kulekerera kwa m'mimba kwa mankhwalawa.

Odwala omwe amalandila metformin mu Mlingo wa 2000-3000 mg tsiku akhoza kusamutsidwa kupita ku Glucofage pa mlingo wa 1000 mg (pazipita - 3000 mg patsiku, wogawidwa 3 waukulu). Mukakonzekera kusinthaku kuti mumwe mankhwala ena a hypoglycemic, muyenera kusiya kumwa ndikuyamba kugwiritsa ntchito Glucofage pamwambapa.

Kuti mukwaniritse bwino shuga wamagazi, metformin ndi insulin zingagwiritsidwe ntchito munthawi yomweyo. Mlingo umodzi woyamba wa Glucofage nthawi zambiri umakhala 500 kapena 850 mg, pafupipafupi makonzedwe amakhala kawiri pa tsiku. Mlingo wa insulin uyenera kusankhidwa potengera kuchuluka kwa shuga m'magazi.

Kwa ana kuyambira zaka 10, Glucofage imatha kutengedwa ngati monotherapy kapena nthawi imodzi ndi insulin. Mlingo woyamba umodzi nthawi zambiri umakhala wa 500 kapena 850 mg, pafupipafupi pakukhazikitsa - 1 nthawi patsiku. Kutengera ndende ya magazi pambuyo masiku 10-15, mlingo umatha kusintha. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Odwala okalamba mlingo wa metformin uyenera kusankhidwa powunikira pafupipafupi zizindikiro za ntchito zaimpso (serum creatinine iyenera kutsimikizidwa osachepera 2-4 pachaka.

Glucophage imatengedwa tsiku ndi tsiku, popanda yopuma. Pambuyo pakutha kwa chithandizo, wodwalayo ayenera kudziwitsa dokotala za izi.

Zotsatira zoyipa

• Matumbo: Nthawi zambiri - kusanza, kusanza, kutsegula m'mimba, kusowa chilimbikitso, kupweteka pamimba. Nthawi zambiri, zizindikiro zotere zimayambika nthawi yoyamba ya chithandizo ndipo, monga lamulo, zimangopita zokha. Kupititsa patsogolo kulekerera kwam'mimba, tikulimbikitsidwa kumwa glucophage panthawi kapena mukatha kudya kawiri pa tsiku. Mlingo uyenera kuchuluka pang'onopang'ono,
• Machitidwe amsempha: nthawi zambiri - kulawa chisokonezo,
• Metabolism: kawirikawiri - lactic acidosis, yokhala ndi mankhwala osagwiritsidwa ntchito kwa nthawi yayitali, mavitamini B12 amatha kuchepa, zomwe ndizofunikira kwambiri kwa odwala omwe ali ndi vuto la kuchepa kwa magazi m'thupi,
• Chiwindi ndi matenda amisili: kawirikawiri - chiwindi, chiwindi ntchito. Monga lamulo, zochitika zoyipa pambuyo pochotsedwa kwa metformin zitatha,
• Khungu ndi minyewa yodukiza: kawirikawiri - kuyabwa, erythema, zotupa.

Zotsatira zoyipa za ana zimafanana muukali ndi chilengedwe kwa iwo omwe ali odwala.

Mimba komanso kuyamwa

Matenda osawerengeka omwe ali ndi shuga panthawi yoyembekezera amawonjezera ngozi ya kubadwa kwa mwana wosabadwa ndi infinatal infa. Umboni woperewera kuchokera ku kafukufuku wazachipatala umatsimikizira kuti kutenga Metformin mwa odwala omwe ali ndi pakati sikungakulitse chiwopsezo chodziwika bwino mwa akhanda.

Mukakonzekera kutenga pakati, komanso ngati mimba imachitika pakumwa mankhwala a Glucofage ngati muli ndi matenda osokoneza bongo a prediabetes, mtundu wa mankhwala uyenera kuthetsedwa. Odwala omwe ali ndi matenda a shuga a 2 amapatsidwa mankhwala a insulin. Madzi a glucose a plasma amayenera kusungidwa pamlingo woyandikira kwambiri kuti achepetse chiopsezo cha kusokonezeka kwa kubereka kwa mwana wosabadwayo.

Metformin imatsimikiziridwa mu mkaka wa m'mawere. Zotsatira zoyipa za akhanda pakubwera pakumwa ma Glucofage sizinawoneke. Komabe, popeza chidziwitso chogwiritsira ntchito mankhwalawa m'gululi pakadali pano sichokwanira, kugwiritsa ntchito metformin panthawi yotsekemera sikulimbikitsidwa. Lingaliro la kusiya kapena kupitiriza kuyamwitsa limapangidwa pambuyo pabwino la kuyamwitsa ndi chiopsezo chotengera zovuta zomwe zimayambira khanda.

GLUCOFAGE (Siofor, Metformin)

Zanu

• Mauthenga: 132
• Yolembedwa: Lachitatu Aprili 25, 2006 11:04
• Mbiri

• Pamwamba

• Nenani izi

Migwirizano ndi magwiritsidwe akusungidwa

Pewani kufikira ana pa kutentha mpaka 25 ° C.

• 500 ndi 850 mg mapiritsi - zaka 5,
• Mapiritsi a 1000 mg - zaka 3.

Oral hypoglycemic mankhwala kuchokera pagulu la Biguanide.
Glucophage imachepetsa hyperglycemia, popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizikhala ndi vuto loti munthu azikhala wathanzi.
Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Imachepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis. Kuchepetsa mayamwidwe m'matumbo.

Metformin imalimbikitsa kapangidwe ka glycogen pochita pa glycogen synthetase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose.
Kuphatikiza apo, ili ndi phindu pa metabolidi ya lipid: imatsitsa cholesterol yathunthu, LDL ndi TG.
Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Pharmacokinetics
Zogulitsa
Mutatha kumwa mankhwalawo mkati, metformin imatenga gawo lonse la chakudya. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. Mtheradi bioavailability ndi 50-60%. Cmax mu plasma imakhala pafupifupi 2 μg / ml kapena 15 μmol ndipo imafikiridwa pambuyo maola 2,5.
Kugawa
Metformin imagawidwa mwachangu mu minofu ya thupi. Sizikugwirizana ndi mapuloteni a plasma.
Kupenda
Amachepetsa pang'ono ndi kupukusidwa ndi impso.
Kuswana
Kuvomerezeka kwa metformin mwa anthu athanzi ndi 400 ml / min (kanthawi kuposa KK), komwe kumawonetsa katulutsidwe ka tubular.
T1 / 2 ndi pafupifupi 6.5 maola.
Pharmacokinetics mu milandu yapadera yamankhwala
Odwala omwe amalephera aimpso, T1 / 2 imawonjezeka, pamakhala chiopsezo cha kuchuluka kwa metformin mthupi.

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso kulephera kwamankhwala othandizira kudya komanso zochitika zolimbitsa thupi:
- akuluakulu, monga monotherapy kapena kuphatikiza mankhwala ena amkamwa a hypoglycemic, kapena insulin,
- mwa ana azaka zapakati pa 10 ndi akulu monga monotherapy kapena osakaniza.

Mapiritsi Amtambo, Glucophage
Mankhwalawa adapangira pakamwa. Piritsi yolumikizidwa imalimbikitsidwa kuti imezedwe yonse, popanda kutafuna kapena kuphwanya, ndimadzi okwanira. Mankhwala tikulimbikitsidwa kuti amwe kapena kudya. Mukasinthira ku metformin kuchokera kwa othandizira ena a hypoglycemic, kayendetsedwe kake kuyenera kuyimitsidwa. Kutalika kwa njira ya mankhwalawa komanso mlingo wa mankhwalawa amatsimikiziridwa ndi dokotala aliyense payekha kwa wodwala aliyense.
Akuluakulu nthawi zambiri amapatsidwa mankhwala a 500-850 mg kawiri pa tsiku. Pakadutsa masiku 10-15 chiyambireni mankhwala, mankhwala a metformin amasinthidwa malinga ndi kuchuluka kwa shuga m'magazi am'magazi. Mlingo uyenera kuchuluka pang'onopang'ono.
Mukamagwiritsa ntchito mankhwalawa limodzi ndi insulin, mankhwala a metformin amaperekedwa pamlingo woyenera, ndipo mlingo wa insulin umasankhidwa payekha kutengera kuchuluka kwa shuga m'magazi a m'magazi.
Mlingo wapamwamba tsiku lililonse wa metformin ndi 3000 mg.

Ana opitirira zaka 10 nthawi zambiri amapatsidwa mankhwala a 500-850 mg 1 pa tsiku. Pakadutsa masiku 10-15 chiyambireni mankhwala, mankhwala a metformin amasinthidwa malinga ndi kuchuluka kwa shuga m'magazi am'magazi. Mlingo uyenera kuchuluka pang'onopang'ono. Mukamagwiritsa ntchito mankhwalawa limodzi ndi insulin, mankhwala a metformin amaperekedwa pamlingo woyenera, ndipo mlingo wa insulin umasankhidwa payekha kutengera kuchuluka kwa shuga m'magazi a m'magazi.

Mlingo umodzi wambiri wa metformin ndi 1000 mg.

Mapiritsi okhala ndi nthawi yayitali Glucofage XR
Mankhwalawa adapangira pakamwa. Piritsi yolumikizidwa imalimbikitsidwa kuti imezedwe yonse, popanda kutafuna kapena kuphwanya, ndimadzi okwanira. Mukasinthira ku metformin kuchokera kwa othandizira ena a hypoglycemic, kayendetsedwe kake kuyenera kuyimitsidwa. Kutalika kwa njira ya mankhwalawa komanso mlingo wa mankhwalawa amatsimikiziridwa ndi dokotala aliyense payekha kwa wodwala aliyense.
Akuluakulu nthawi zambiri amapatsidwa piritsi limodzi la mankhwalawa 1 kamodzi patsiku madzulo. Pakadutsa masiku 10-15 chiyambireni mankhwala, mankhwala a metformin amasinthidwa malinga ndi kuchuluka kwa shuga m'magazi am'magazi. Mlingo uyenera kuchuluka nthawi 1 pa sabata ndi 500 mg mpaka mphamvu ya hypoglycemic ikuchitika.
Mukamagwiritsa ntchito mankhwalawa limodzi ndi insulin, metformin nthawi zambiri imaperekedwa pa 500 mg kamodzi patsiku, ndipo mlingo wa insulin umasankhidwa payekha kutengera mulingo wa glucose m'madzi a m'magazi.
Ngati mphamvu ya hypoglycemic ndi yosakwanira mukamagwiritsa ntchito mapiritsi 4 a 1 tsiku lililonse patsiku, tengani mapiritsi 2 a mankhwalawa 2 pa tsiku.
Mlingo wapamwamba tsiku lililonse wa metformin ndi 2000 mg.
Kwa odwala omwe adalandira kale chithandizo cha metformin, Glucofage XR iyenera kutumikiridwa muyezo wofanana ndi tsiku lililonse la metformin yomwe wodwalayo adalandira.
Odwala akuvutika ndiimpso ntchito, komanso okalamba odwala, mankhwala ayenera kutumikiridwa mu koyamba mlingo. Kusintha kwa Mlingo kwa odwala koteroko kuyenera kutengera kuchuluka kwa shuga m'magazi am'magazi komanso kuwunika kwa impso.

Kutsimikiza kwamafupipafupi a mavuto: pafupipafupi (≥1 / 10), kawirikawiri (≥1 / 100, Ndingathe kusewera masewera ndikumwa mapiritsi?

Malinga ndi kafukufuku waposachedwa, munthawi yomwe amamwa mankhwalawa siwoponderezedwa. Kumapeto kwa zaka zana zapitazi, panali malingaliro osiyana. Hypoglycemic wothandizila ndi kuchuluka kwazinthu zimayambitsa lactic acidosis.

Zogwiritsa ntchito Metformin komanso zofananira zinaletsedwa.

Mankhwala a hypoglycemic a mibadwo yoyamba adayambitsa zovuta zina, kuphatikizapo chiwopsezo cha kupangika. Ichi ndi chiopsezo cha moyo momwe lactic acid m'thupi imafikira kwambiri.

Kuchuluka kwa lactate kumalumikizidwa ndi kuphwanya acid-base metabolism mu minofu ndi kusowa kwa insulini m'thupi, ntchito yomwe ndiyo kuphwanya shuga. Popanda chithandizo chamankhwala mwachangu, munthu yemwe ali ndi vutoli. Ndi kukula kwa tekinoloje ya pharmacological, zoyipa zamagwiritsidwe ntchito ka hypoglycemic zidachepetsedwa.

• Osaloletsa kusowa kwamadzi,
• muyenera kuyang'anira kupumira koyenera nthawi yophunzirira,
• kuphunzitsa kuyenera kukhala kwadongosolo, kopumula koyenera kuti uchiritse,
• kuchuluka kwamphamvu kumachuluka pang'onopang'ono,
• ngati mukumva kutentha m'misempha, muyenera kuchepetsa kulimbitsa thupi.
• ziyenera kukhala zogwirizana ndi mavitamini ndi michere yambiri, kuphatikizapo mavitamini a magnesium, B,
• Zakudya ziyenera kuphatikizapo kuchuluka kwa mafuta acids athanzi. Amathandizira kugwetsa lactic acid.

Glucophage ndi zomanga thupi

Thupi la munthu limagwiritsa ntchito mafuta komanso ngati mphamvu.

Mapuloteni ndi ofanana ndi zomanga chifukwa ndi gawo lofunikira pomanga minofu.

Pakakhala kusowa kwa chakudya chamagulu, thupi limagwiritsa ntchito mafuta mphamvu, zomwe zimapangitsa kuchepa kwamafuta amthupi ndikupanga kupumula kwa minofu. Chifukwa chake, omanga thupi amatsata pakuumitsa thupi.

Makina a Glucophage ntchito ndikulepheretsa dongosolo la gluconeogeneis, lomwe kudzera mu glucose limapangidwa m'thupi.

Mankhwalawa amasokoneza kuyamwa kwa zakudya zamafuta, zomwe zimakwaniritsa ntchito zomwe womanga thupi amachita. Kuphatikiza pa kupondereza gluconeogeneis, mankhwalawa amawonjezera kukana kwa insulin, kutsitsa cholesterol, triglycerides, lipoproteins.

Omanga a thupi anali ena mwa oyamba kugwiritsa ntchito mankhwala a hypoglycemic kuti atenthe mafuta. Zochita zamankhwala zimafanana ndi zochita za wothamanga. Thupi la hypoglycemic lingathandize kukhalabe ndi zakudya zama carb ochepa komanso kukwaniritsa masewera munthawi yochepa.

Zotsatira zoyipa

Ndi mphamvu zake, glucophage ikhoza kuyambitsa zinthu zoipa mthupi la munthu. Malinga ndi kafukufuku, zoyipa zazikulu kwambiri zimapezeka chifukwa chomwa mankhwalawo m'matumbo am'mimba.

Zotsatira zoyipa za Glucophage zitha kuwoneka:

• kutsegula m'mimba
• nseru
• ukufalikira
• kulawa kwazitsulo mkamwa.

Mokulira kuchuluka kwa chakudya chamagulu m'zakudya, kumakhala kowopsa kwambiri.

Zizindikiro zimachitika kumayambiriro kwa makonzedwe ndipo pamapeto pake, kuchepa koyenera kwa zakudya zamagulu ochulukitsa, zimadutsa zokha. Pali chiopsezo cha kupangika kwa lactic acidosis, imatha kuwoneka ngati vuto la impso ndi mtima limagwira.

Ndi chitukuko cha lactic acidosis, mankhwalawa amathetsedwa.

Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumalepheretsa kuyamwa kwa B12, komwe kungayambitse kuchepa. Kupangika kwa zotupa pakhungu sikuphatikizidwa.

Zotsatira pa impso

Mankhwala a hypoglycemic amakhudza mwachindunji impso. Gawo lolimbikira silimapukusidwa ndikufotokozedwa ndi impso osasinthika.

Ndi osakwanira aimpso ntchito, chinthu yogwira bwino ntchito sanachotse, chilolezo aimpso amachepetsa, zomwe zimathandiza kuti kudzikundikira kwake zimakhala.

Pa mankhwala, kuyang'anira kusinthasintha kwa glomerular ndi kuchuluka kwa shuga m'magazi ndikofunikira. Chifukwa cha momwe zinthu zimagwirira ntchito pa impso, sizikulimbikitsidwa kumwa mankhwalawa chifukwa cha kulephera kwa impso.

Zotsatira pa kusamba

Glucophage si mankhwala osokoneza bongo ndipo samakhudza mwachindunji magazi akusamba. Kufikira pamlingo wina, imatha kukhala ndi vuto pa thumba losunga mazira.

Mankhwalawa amawonjezera kukana kwa insulini ndipo amakhudza zovuta za metabolic, zomwe zimadziwika ndi polycystic.

Mankhwala a Hypoglycemic nthawi zambiri amaperekedwa kwa odwala omwe amafotokozera, kuvutika ndi hirsutism. Kubwezeretsa insulin sensitivity kwagwiritsira ntchito bwino ntchito mankhwalawa osabereka omwe amayamba chifukwa cha zovuta za ovulation.

Chifukwa cha momwe amachitira pancreas, kugwiritsa ntchito kwadongosolo komanso kwa nthawi yayitali mankhwala osokoneza bongo kumakhudza ntchito yamchiberekero. Msambo ungasinthe.

Kodi amayamba kuuma pamankhwala?

Wothandizira hypoglycemic, wokhala ndi zakudya zoyenera, samatha kuyambitsa kunenepa kwambiri, chifukwa amatchinga kuphwanya kwa chakudya chamafuta m'thupi. Mankhwala amatha kusintha kagayidwe kake ka thupi.

Glucophage imathandizira kubwezeretsa mapuloteni ndi mafuta, zomwe zimabweretsa kuwonda.

Kuphatikiza pa zotsatira za hypoglycemic, mankhwalawa amalepheretsa kuchepa kwamafuta ndi kuchuluka kwake kwa chiwindi. Nthawi zambiri, mukamagwiritsa ntchito mankhwalawa, chilakolako chochepa thupi chimachepa, zomwe zimapangitsa kuti azitha kudya mosavuta.

Mankhwalawa alibe mphamvu iliyonse ya minofu ya adipose. Zimangosokoneza mayamwidwe azakudya zokhala ndi zomanga thupi, kuchepetsa shuga m'magazi ndikuwonjezera kuyankha kwa insulin.

Kugwiritsa ntchito glucophage sikuti ndi vuto laku kunenepa kwambiri, muyenera kuwona zoletsa kugwiritsa ntchito mafuta osavuta komanso kukhala olimba. Popeza chinthu chogwira ntchito chimakhudza ntchito ya impso, kutsatira ndikofunikira.

The kapangidwe ndi kumasulidwa mawonekedwe a mankhwala "Glucophage"

Metformin hydrochloride ndiye chinthu chogwira ntchito cha mankhwalawo. Zothandiza ndi izi: magnesium stearate, povidone, hypromellose (2910 ndi 2208). Mankhwalawa amapezeka mu mawonekedwe am'mapiritsi omwe ali ndi Mlingo wothandizirana ndi kuchuluka kwa 500, 850 ndi 1000 mg. Mapiritsi a Biconvex ndiwotupa. Amatetezedwa ndi chovala choyera cha filimu. Pali zoopsa kumbali zonse za piritsi, pa imodzi mwa izo mwawonetsedwa.

Komanso ogula amapatsidwa wothandizira kuti amasulidwe - Glucofage Long. Ndemanga za ogwiritsa ntchito mankhwalawa zimawonekeranso pamankhwala abwino. Mankhwala omwe amafunsidwa kawirikawiri m'mafakisoni ndi 500 ndi 750 mg ya metformin.

Kugwirizana kwa "Glucophage" ndi kuwonda: mfundo yofunikira

Gawo lalikulu la mankhwalawa, metformin, lakonzedwa kuti muchepetse shuga m'magazi, omwe amadzuka atatha kudya (njira yachilengedwe yamoyo m'chilengedwe). Kenako kapamba amalumikizana ndi njirayi, ntchito zomwe zimaphatikizapo kupanga, kenako, kusintha glucose kukhala maselo amafuta.

Mwa zabwino zazikulu za mankhwala "Glucofage Long" chifukwa cha kuwonda, zotsatirazi zitha kudziwika:

• matenda a lipid metabolism osagwirizana ndi matenda a shuga,
• kuletsa kuwonongeka kwa mafuta omwe amalandiridwa ndi chakudya, ndipo, potero, kusintha kwawo kukhala mafuta amthupi,
• kuwunikira komanso kusintha matenda a shuga ndi mafuta “oyipa” omwe ali m'magazi,
• kuchepa kwachilengedwe pachilakolako ndi kusilira kwa maswiti, komwe kumalumikizidwa ndi kubereka kwa kapangidwe ka insulin.

Zinthu zonsezi pamodzi zimathandizira odwala matenda ashuga kuwongolera kuchuluka kwa shuga ndikuwongolera kwambiri moyo wawo potengera njira za endocrine.

Mphamvu ya metformin imayambitsa kutsika kwa glucose wamagazi, ndipo mamolekyulu a shuga amayenda molunjika kumtunda. Ndi pomwepo kuti shuga amawotcha kwambiri, kuyamwa kwa michere kumachitika ndikuchepetsa (mwachitsanzo, kuchuluka ndi kuchuluka kwa maselo amafuta sikumachitika).

Kuphatikiza apo, mankhwala a Glyukofazh ndi Glyukofazh Long, kuwunika kwa iwo omwe amachepetsa thupi kumawapatsa mwayi wochepetsa kudya, chifukwa chake palibe kudya kwambiri ndipo, chifukwa chake, insulin imatulutsidwa m'magazi.

Mlingo komanso dongosolo la momwe mungagwiritsire ntchito

Mankhwala "Glucofage Long" samalimbikitsa kutenga malangizo ogwiritsa ntchito popanda mankhwala a dokotala. Ngakhale kuchuluka kokwanira kwa ogwira ntchito yazaumoyo ali ndi chiyembekezo chogwiritsa ntchito zopangidwa ndi metformin kuti muchepetse kunenepa.

Malangizo wamba ndi njira yochizira kuyambira masiku 10 mpaka 22, ndiye kuti muyenera kupuma kwa miyezi iwiri. Pakapita kanthawi, maphunzirowo atha kubwerezedwa.Pogwiritsa ntchito pafupipafupi, pamakhala mwayi kuti thupi lizisinthasintha (kugwiritsa ntchito) mankhwalawa ndikuchepetsa mphamvu zake, ndiye kuti, metformin imataya mwayi wowonetsa bwino mawonekedwe owotchera mafuta.

Dokotala amasankha mulingo woyenera aliyense payekha kwa wodwala aliyense, kutengera mtundu waumoyo komanso magawo a anthropometric (kulemera, kutalika, msinkhu). Kuchuluka kwa tsiku lililonse kwa mankhwalawa ndi 500 mg. Nthawi zambiri kumwa mapiritsi usiku. Komabe, nthawi zambiri "Glucofage 500" yochepetsa thupi imayikidwa kawiri masana, nthawi ya nkhomaliro komanso madzulo. Pafupipafupi, mlingo ungathe kuwonjezeredwa mpaka 3 Mlingo - 1500 mg patsiku (mwachilengedwe, osati palokha, koma monga momwe adanenera dokotala). Pankhaniyi, ndizomveka kuyang'anira magwiridwe anthawi yayitali "Glucofage Long 750" kuti muchepetse kunenepa. Kuunika kwa madotolo ndi odwala kumawonetsa chida ichi kukhala chothandiza komanso chosavuta kugwiritsa ntchito (1500 mg mu Mlingo iwiri). Mapiritsi aledzera musanadye kapena nthawi ya chakudya.

Mlingo wapamwamba wa tsiku lililonse wa mankhwalawa (apanso, monga momwe adanenera dokotala) sangadutse 3000 mg. Ndi kumwa motere, ndibwino kuti muthe kutenga Glucofage 1000 kuti muchepetse thupi (katatu patsiku piritsi lokhala ndi metformin mu 1000 mg).

Kuchepetsa pang'onopang'ono kwa mankhwalawa kungakhudze kukonzekera kwa m'mimba kwa mankhwalawa.

Ndani ayenera kupewa kugwiritsa ntchito mankhwalawa?

Popeza Glucofage sikuti ndi vitamini kapena zakudya zowonjezera, koma adapangira kuti azigwiritsidwa ntchito ndi odwala omwe ali ndi matenda amtundu wa 2, ali ndi mndandanda wochititsa chidwi wa zotsutsana.

Anthu athanzi omwe amamwa mankhwala okhala ndi metformin amakhala ndi chiopsezo chotenga matenda osagwirizana ndi chakudya, omwe amadziwonetsa pang'onopang'ono momwe thupi la munthu limayendera insulin yake. Izi zimadzetsa chitukuko cha matenda ashuga.

Kuphatikiza apo, onse Glyukofazh ndi Glukofazh Long aletsedwa kugwiritsa ntchito malangizo omwe amagwiritsidwa ntchito ndi anthu omwe ali ndi hypersensitivity popanga zigawo zina. Kupatuka kulikonse pakugwira ntchito kwa impso, chiwindi, mtima ndi zifukwa zokwanira zokanira kugwiritsa ntchito mankhwalawa. Matenda aliwonse omwe ali pachimake kwambiri, nthawi yokonzanso ntchito, kupweteka kwa thupi, mkaka - izi zonse zimaletsa kugwiritsa ntchito "Glucofage" kuchepetsa thupi.

Musamwe mankhwala kwa odwala omwe ali ndi vuto lililonse la matenda ashuga: odwala matenda amtundu 1, komanso mtundu uwu wa matenda ashuga 2, pomwe wodwalayo alibe insulin mthupi. Sizoletsedwa kutenga Glucophage kwa anthu omwe ali ndi magazi m'thupi, matenda oopsa a bronchopulmonary, zovuta zamatumbo momwe magazi acid amakhala apamwamba kuposa abwinobwino.

Mawonetsero osayenera

Popeza mankhwalawa adapangidwa kuti athane ndi matenda oopsa monga matenda a shuga, sangalephere kukhala ndi zotsatirapo zilizonse. Nthawi zambiri, pamakhala zotsatira zoyenera kumwa mankhwalawa "Glucophage". Ndemanga ya kuchepetsa kulemera imafunsa mitundu yosiyanasiyana yamatumbo am'mimba.

Ngati, motsutsana ndi maziko ogwiritsa ntchito mankhwala okhala ndi metformin kuti muchepetse kunenepa, kutsekula m'mimba kapangidwe kapenanso kupangika kwa matumbo m'matumbo kumawonjezereka, chifukwa chake chingakhale chakudya chochuluka mwa chakudya. Muyenera kuwerengera zomwe mumadya tsiku lililonse. Ngati mukusanza mukamwa mankhwalawa, muyenera kuchepetsa kuchuluka kwa mankhwalawa. Nthawi zambiri mumatha kumva za ma spasms m'matumbo ndi mutu womwe umachoka mwachangu.

Popereka mankhwala a Glucophage ndi Glucophage Long slimming kwa odwala, kuwunika kuyeneranso kukumbukiridwa. Ogwira ntchito zachipatala ati kuchuluka kwa zotsatirapo zake kumazimiririka lokha patatha masiku ochepa chiyambireni mankhwalawa kapena atangomaliza kumwa.

Pamaso pa zinthu zomwe zimayambitsa vuto, lactic acidosis imayamba. Kuchita koteroko kumawonedwa kukhala koopsa kwambiri. Chofunikira chake ndikukulitsa maphunziro komanso kagayidwe kosayenera m'thupi. Zizindikiro zotsatirazi zikuwonetsa kukhalapo kwa mankhwalawa "Glucophage": kusanza, kutsegula m'mimba, kupumira mwachangu, kupweteka m'mimba, kusazindikira. Kukula kwa zotere kumafunika kuchotsedwa kwa mankhwalawa, kuchipatala mwachangu kuti mupeze mulingo wa lactate m'magazi komanso molingana ndi zotsatira za chithandizo chamankhwala. Pochotsa metformin ndi mkaka wa mthupi, chithandizocho chikhala chothandiza kwambiri.

Kukhazikika kosagwiritsidwa ntchito kwa mankhwalawa pogwiritsa ntchito metformin kumatha kuyambitsa zovuta muubongo (monga kuwonetsa kuchepa kwa shuga) komanso kukula kwa matenda osokoneza bongo.

Ngakhale odwala omwe amamwa mankhwala mu Mlingo wocheperako (kuyambira Glucofage 500) chifukwa cha kuchepa thupi amatha kukhala ndi malingaliro olakwika kwambiri ngati malangizo osagwiritsidwa ntchito satsatiridwa. Muyenera kusiya zakudya zomwe zili ndi chakudya chochuluka: zipatso zouma, koloko, maswiti ndi zakudya zina zokhala ndi shuga. Zosathandiza kwambiri panthawiyi azikhala kudya chimanga, mbatata, pasitala ndi mpunga woyera.

Kugwiritsa ntchito mankhwala okhala ndi metformin motsutsana ndi zakudya zama calorie otsika (zakudya zosaposa 1000 kcal) zomwe zimakhala ndi zakumwa zoledzeretsa ndi zakumwa sizigwirizana kwenikweni.

Palibe zakudya zapadera mukamagwiritsa ntchito Glucofage. Palibe zoletsa zapadera pa zonunkhira ndi mchere mwina.

Kuchita ndi mankhwala ena

Zambiri pazomwe mungatengere "Glucophage" zili m'malangizo ogwiritsira ntchito mankhwalawa. Kudya limodzi ndi danazol kungapangitse kukula kwa vuto la hyperglycemic. Kugwiritsa ntchito munthawi yomweyo kukonzekera kwa metformin ndi zinthu za ethanol kumatha kuyambitsa lactic acidosis panthawi yamkati poyizoni wakumwa. Kuthekera kotenga gawo lotereli kumakulirakulira ndi njala, zakudya zopatsa mphamvu pang'ono komanso kulephera kwa chiwindi.

Odwala omwe ali ndi matenda ashuga ayenera kusamala akamagwiritsa ntchito Glucofage ndi antipsychotic kapena glucocorticosteroids (GCS). Zikatero, mlingo wa mankhwala omwe ali ndi metformin uyenera kusinthidwa malinga ndi kuchuluka kwa shuga m'magazi. Kuphatikiza kwa Glucophage ndi loopback diuretics kumafunikanso chisamaliro chapadera. Zikatero, pamakhala chiopsezo pakupatuka kwa impso ndipo, chifukwa chake, kukula kwa zizindikiritso za lactic acidosis.

Mankhwala othandizira magazi amatha kuchepetsa magazi. Chifukwa chake, pakafunika "mdera" lotere, muyeso wa metformin uyenera kusinthidwa.

Glucophage ndi zolimbitsa thupi

Osati kale kwambiri, pokhudzana ndi zochitika zolimbitsa thupi ndi kugwiritsa ntchito mankhwala a Glucofage, kuwunika kwa kunenepa komanso ogwira ntchito kuchipatala adavomereza kuti muzochitika zotere zimachitika kuti minformin imatsika kwambiri, chifukwa lactic acid imatulutsidwa m'matumbo, omwe amatsutsa mphamvu ya mankhwalawa powonjezera acidity magazi. Komabe, kafukufuku waposachedwa m'derali watsimikizira zokayikitsa. Komanso, tsopano zikuwonekeratu kuti Glucophage ndi moyo wokangalika pamodzi zimathandizira njira yochepetsera thupi.

Ngakhale mutatenga mankhwala ochepa a metformin (mwachitsanzo, Glucofage 500), kuwunikira kwa kuchepetsa thupi (omwe saiwala zolimbitsa thupi) nthawi zambiri kumakhala koyenera. Chowonadi ndi chakuti gawo lalikulu la mankhwalawo limathandizira kuperekera shuga mwachindunji kwa minofu, komwe imatenthedwa bwino, ngati munthu amene akufuna kuchepa thupi saayiwala za masewera olimbitsa thupi. Kupanda kutero, ma metabolic a thupi "amayendetsa" glucose mozungulira mpaka atatembenuka kukhala glycogen ndipo sasintha kukhala mafuta. Chifukwa chake, mathedwe amadzitsimikizira okha: Asanatenge "Glucophage", ndikofunikira kupanga pulogalamu yochita zolimbitsa thupi ndikutsatira mosamalitsa. Ndi pokhapo izi pomwe munthu angayembekezere zabwino.

Kodi lingaliro la ogwira ntchito yazaumoyo ndi chiyani pa Glucofage?

Pakadali pano, madokotala alibe mgwirizano pa kutha ndi chitetezo cha metformin pakuchepetsa thupi. Chithandizo chamankhwala sichimaletsa kugwiritsa ntchito Glucophage ndi Glucophage Long kuchitira kunenepa. Ndemanga za akatswiri ambiri azachipatala ndi zabwino. Ngakhale gawo lina la madokotala silimawona kuti chithandizo chotere sichobvomerezeka, chifukwa mankhwalawa angapangitse kupatuka mu kayendedwe ka car metabolic metabolism, amachititsa kukula kwa matenda a shuga ndi lactic acidosis, omwe amawopseza moyo wa wodwalayo.

Pofuna kumveketsa chowonadi mmaiko ambiri padziko lapansi, maphunziro oyenerera akuchitika pankhaniyi. Chifukwa chake, mu 2014, maphunziro adachitika pamaziko a Cardiff University, momwe anthu pafupifupi 180,000 adatenga nawo gawo. Zotsatira zake, zidatsimikiziridwa kuti metformin ndi kukonzekera komwe kuli nako kumatha kuwonjezera kuchuluka kwa moyo osati mwa anthu omwe ali ndi matenda ashuga okha, komanso mwa iwo omwe sazindikira. Kuphatikiza apo, zidapezeka kuti kugwiritsa ntchito metformin kumachepetsa kukalamba mthupi.

Malingaliro odwala

Popeza makambirano sakukhudzana ndi zowonjezera mavitamini kapena mavitamini, koma za mankhwala oopsa, ndizachilengedwe kuti pamakhala malingaliro osiyanasiyana za iwo pakati pa ogula.

Kumbali imodzi, odwala omwe adamwa ngakhale mankhwala ochepa kwambiri (mwachitsanzo, nthawi imodzi yotsatila Glucofage 500), ndemanga zimasiya zabwino kwambiri pamankhwala. Ndipo kuchepa kwa njala kumawonekera, ndipo kulemera kwamthupi kumachepa. Zowona, ena amakhulupirira kuti kulemera kumachepetsedwa pang'onopang'ono, 2-3 kg kupitilira mwezi. Komabe, ogwira ntchito yazaumoyo amawona kuti mlingo uwu ndiwopeza bwino kwambiri thupi lonse. Chofunika kwambiri, musadzipangire nokha. Onetsetsani kuti mukumana ndi dokotala yemwe amayesa momwe wodwalayo alili, aganize kutalika kwake, kuchuluka kwake, msinkhu wake, sankhani mlingo woyenera kwambiri ndikupanga njira yothandizira kuti mukhale ndi zotsatira zabwino.

Pali odwala omwe adayesera kutenga Glucofage (okha, chifukwa katswiri wazachipatala woyenerera sangapange nthawi yayitali) kuti apange minofu pomanga thupi. Apa muyenera kudziwa kuti limagwirira a anabolic, lofunikira kwambiri pakukula kwa minofu, imayambitsa mndandanda wonse wa zinthu, kuphatikizapo glucose ndi insulin. Ndipo "Glucophage" ndi mankhwala aliwonse okhala ndi Metformin amapangitsa kuti thupi lipangike, lofanana ndi njala, lomwe limabwera atatha kulimbitsa thupi. Chifukwa chake, kuwunikira kwa odwala kotere kuti mankhwalawa sanathandize.

Pali zovuta zokwanira zogwiritsa ntchito mankhwalawa "Glucofage." Ndemanga ya kuchepa thupi lipoti la kuchepa mphamvu, kakulidwe kazotsatira zoyipa. Zikatero, wina sakanakhoza kulekerera kwa masiku angapo mpaka thupi litazungulira ku Glucofage. Kwa ena, kukhalapo kwa matenda othandizirana kumadzetsa mavuto ambiri, ndipo simungathe kuchita kalikonse pano - muyenera kulabadira mankhwala ena kuti muchepetse kunenepa kwambiri. Ndipo wina sanalandire malingaliro a malangizo omwe angagwiritsidwe ntchito pakuchepetsa kudya kwa zakudya zamagulu ochulukirapo, kusakanikirana kophatikiza metformin ndi zakudya zama calorie ochepa, zinthu zakumwa zoledzeretsa, okodzetsa, antipsychotic ndi zinthu zina.

Nthawi zambiri, ndemanga zoyipa zokhudza Glucofage zitha kunenedwa pokhapokha ngati mankhwalawa akumwa, omwe amachokera ku gulu lalikulu, amapangidwira makamaka odwala matenda a shuga, ndipo amatha kusokoneza kagayidwe kazakudya mwa munthu wathanzi.

Ubwino wa mankhwalawa ndikuti Glucofage ndi yotsika mtengo kwambiri ndipo imagulitsidwa pa intaneti yopanda mankhwala popanda mankhwala, zomwe zimapangitsa kuti anthu athe kupeza ndalama iliyonse.

Mulimonsemo, musanapitirize ndi kulandira Glucofage kuti muchepetse kunenepa, muyenera kufunsa uphungu wa akatswiri azachipatala omwe ali ndi mbiri yoyenera. Iyi ndiye njira yokhayo yopezera zotsatira zabwino popanda kuyika thupi lanu pangozi.