Symlo 5 mg mapiritsi: malangizo ndi kuwunika pa mankhwalawa
ICD: E78.0 Hypercholesterolemia E78.2 Hyperlipidemia wosakaniza
Zogulitsa
Pambuyo pakukonzekera pakamwa, simvastatin imatengedwa bwino kuchokera m'matumbo am'mimba (pafupifupi 85%). Cmax imatheka patatha maola 4 mutayamba kumwa.
Kumwa mankhwalawa nthawi yomweyo musanadye chakudya chamafuta ochepa sikukhudza f.
Kutulutsa Fomu
Sanapeze zomwe mukufuna?
Malangizo onse amomwe mankhwalawo "simlo (simlo)" angapezeke pano:
Madokotala okondedwa!
Ngati mukumva kuperekera mankhwala kwa odwala anu - gawani zotsatira (kusiya ndemanga)! Kodi mankhwalawa adathandizira wodwala, kodi panali zotsatirapo zilizonse zomwe zimachitika panthawi ya chithandizo? Zomwe mukuwona zidzakhala zosangalatsa kwa anzanu komanso odwala.
Okondedwa odwala!
Ngati mankhwalawa adakulangizani inu ndipo mwalandira chithandizo chamankhwala, ndiwuzeni ngati chinali chothandiza (ngakhale chinakuthandizani), ngakhale panali zovuta zina, zomwe mumakonda / simunazikonde. Anthu zikwizikwi akufuna kuyang'ana pa intaneti zamankhwala osiyanasiyana. Koma ochepa okha ndi omwe amawasiya. Ngati inu panokha simusiya ndemanga pamutuwu - ena onse sangakhale ndi zomwe angawerenge.
Zizindikiro zogwiritsidwa ntchito
Mtundu woyamba wa IIa ndi mtundu wa IIb hypercholesterolemia (wokhala ndi vuto lochiritsa pakudya kwa odwala omwe ali ndi chiopsezo chowonjezereka cha coronary atherosulinosis), hypercholesterolemia ndi hypertriglyceridemia, hyperlipoproteinemia, yomwe singathe kuwongoleredwa ndi zakudya zapadera komanso masewera olimbitsa thupi.
Kupewera kwa myocardial infarction (kuti muchepetse kupita patsogolo kwa matenda a coronary atherosulinosis), matenda a sitiroko ndi kusakhalitsa kwa matenda amitsempha yamagazi.
Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo
Mkati, kamodzi, madzulo. Ndi hypercholesterolemia yofatsa kapena yolimbitsa, mlingo woyambirira ndi 5 mg, ndi hypercholesterolemia yayikulu pamankhwala oyambira 10 mg / tsiku, ndi mankhwala osakwanira, mankhwalawa amatha kuchuluka (osapitirira masabata 4), mlingo waukulu wa tsiku ndi tsiku ndi 80 mg.
Ndi matenda a mtima a coronary, mlingo woyambirira ndi 20 mg (kamodzi, madzulo), ngati pakufunika, mlingo umakulitsidwa pang'onopang'ono sabata iliyonse 40 mpaka 40 mg. Ngati ndende ya LDL ndi yochepera 75 mg / dl (1.94 mmol / L), kuchuluka kwa mafuta m'thupi kumachepera 140 mg / dl (3,6 mmol / L), mlingo uyenera kuchepetsedwa.
Odwala omwe ali ndi vuto la aimpso kulephera (CC osakwana 30 ml / mphindi) kapena kulandira cyclosporine, fibrate, nicotinamide, mlingo woyambira ndi 5 mg, mlingo waukulu wa tsiku ndi tsiku ndi 10 mg.
Zotsatira za pharmacological
Mankhwala ochepetsa lipid omwe amapezeka kuti amapangidwa kuchokera ku mphamvu yampweya wa Aspergillus terreus ndi lactone wosagwira ntchito; amapita hydrolysis m'thupi kuti apange hydroxy acid. Metabolite yogwira imapunditsa kuchepa kwa HMG-CoA, ma enzyme omwe amathandizira pakuyamba kwa mapangidwe a mevalonate ku HMG-CoA. Popeza kutembenuka kwa HMG-CoA kukhala mevalonate ndi gawo loyambirira kapangidwe ka cholesterol, kugwiritsidwa ntchito kwa simvastatin sikumapangitsa kudzikundana kwa mankhwala owopsa mthupi. HMG-CoA imapangidwa mosavuta ku acetyl-CoA, yomwe imakhudzidwa ndi njira zambiri zopangira thupi.
Amachepetsa kuchuluka kwa TG, LDL, VLDL ndi cholesterol yathunthu m'madzi am'magazi (hypercholesterolemia, yosakanikirana ndi hyperlipidemia, kuwonjezeka kwa cholesterol ndi chiopsezo). Kuchulukitsa ndende ya HDL ndikuchepetsa kuchuluka kwa LDL / HDL ndi cholesterol / HDL yathunthu.
Kukhazikika kwa masabata awiri pambuyo pa kuyambika kwa makonzedwe, chithandizo chokwanira kwambiri pambuyo pa masabata a 4-6. Zotsatira zake zimapitiliza ndi chithandizo chopitilira, pakutha kwa chithandizo, mafuta a cholesterol amabwerera pamlingo wawo woyambirira (chithandizo chisanachitike).
Malangizo ogwiritsira ntchito
| Kupanga Simlo
Omwe amathandizira: chimanga wowuma, lactose, microcrystalline cellulose, sodium starch glycolate, gelatinized starch, chikasu chitsulo okusayidi, isopropanol, hydroxytoluene butylate, madzi oyeretsedwa, citric acid monohydrate, talc oyeretsedwa, magnesium stearate, hydroxyphenyl methylene dichloropen. Ma PC 10 - matuza (2) - mapaketi a makatoni.
Omwe amathandizira: chimanga wowuma, lactose, microcrystalline cellulose, sodium starch glycolate, gelatinized starch, red iron oxide, isopropanol, hydroxytoluene butylate, madzi oyeretsedwa, citric acid monohydrate, talc yoyeretsedwa, magnesium stearate, hydroxyphenylmethylene methylypyleyleyleyleyleyleyleylene methylpylstylene. Ma PC 10 - matuza (2) - mapaketi a makatoni.
Omwe amathandizira: chimanga wowuma, lactose, microcrystalline cellulose, sodium starch glycolate, gelatinized starch, red iron oxide, isopropanol, hydroxytoluene butylate, madzi oyeretsedwa, citric acid monohydrate, talc yoyeretsedwa, magnesium stearate, hydroxyphenylmethylene methylypyleyleyleyleyleyleyleylene methylpylstylene. Ma PC 10 - matuza (2) - mapaketi a makatoni.
tabu. sheath, 5 mg: 20, 28, 30 kapena 42 ma PC.
tabu. sheath, 10 mg: 20, 28, 30 kapena 42 ma PC.
tabu. sheath, 20 mg: 20, 28, 30 kapena 42 ma PC. Contraindication Simlo
- matenda a chiwindi - aakulu chiwindi matenda mu pachimake gawo, - kuchuluka kosalekeza mu ntchito ya transaminase ochokera kosadziwika, - mkaka wa m'mawere (yoyamwitsa), - ana ndi achinyamata osakwana zaka 17, - Hypersensitivity to simvastatin ndi zina za mankhwala, - Hypersensitivity kwa ena a HMG-CoA reductase inhibitors. Mlingo ndi makonzedwe Simlo
Mlingo wothandizira komanso nthawi ya chithandizo amakhazikitsidwa payekhapayekha. Kutengera kuopsa kwa hypercholesterolemia, mlingo woyambirira ndi 5 mg / tsiku. Ndi kwambiri hypercholesterolemia - 10 mg 1 nthawi / tsiku. Ngati ndi kotheka, onjezani kumwa mankhwala kwa masabata anayi. Mlingo wambiri watsiku ndi tsiku ndi 40 mg. Mankhwala ayenera kumwedwa 1 nthawi / tsiku madzulo, musanadye kapena chakudya. Kwa odwala omwe amalandira ma immunosuppressants, mlingo woyambira wopangira ndi 5 mg / tsiku, mlingo waukulu wa tsiku lililonse ndi 5 mg / tsiku. Odwala omwe ali ndi zofatsa kapena zolimbitsa thupi aimpso sayenera kusintha njira. Kwa odwala omwe amalephera kwambiri aimpso, muyeso woyamba ndi 5 mg / tsiku, pomwe gulu ili la odwala likuyenera kuwunika pafupipafupi. Zotsatira zoyipa Simlo
Kuchokera pamimba yogaya chakudya: pafupipafupi - kudzimbidwa, kutsekula m'mimba, kusowa kwa chilimbikitso, kugona mseru, nseru, kupweteka kwam'mimba, kapamba, mwina kuwonjezereka kwa kuchuluka kwa transaminases ndi CPK m'madzi am'magazi (nthawi zambiri kumapeto kwa mwezi woyamba wa mankhwala). Pakatikati pa sabata la 2 ndi 4 kuyambira pachiwongola, kuwonjezeka kwa magazi m'magazi a ALT, AST ndi alkaline phosphatase ndikotheka. Kuchuluka kwazizindikiro kumeneku kumawonedwa mozungulira sabata la 8 la mankhwala. Pambuyo pakutha kwa mankhwalawa, mankhwala a enzyme amachepetsa kukhala achilendo. Kumbali ya mtima dongosolo: ochepa hypotension amatha (zambiri zimachitika pamene kumwa mankhwala 10 mg / tsiku, wosakhalitsa m'chilengedwe ndipo safuna kuwongolera Mlingo wambiri). Kuchokera ku chapakati mantha dongosolo ndi zotumphukira mantha dongosolo: mutu, kusowa tulo, asthenia, chizungulire ndi zotheka. Kuchokera ku minculoskeletal system: kawirikawiri - myopathy, rhabdomyolysis. Kuchokera ku hemopoietic dongosolo: kawirikawiri - eosinophilia, thrombocytopenia. Thupi lawo siligwirizana: kawirikawiri - urticaria, angioedema. Zina: kawirikawiri - photosensitization, vasculitis, lupus-like syndrome. Mankhwala nthawi zambiri amaloledwa. Zotsatira zoyipa nthawi zambiri zimakhala zofatsa komanso zosakhalitsa.
Zambiri pa bongo wa mankhwala Simlo sanaperekedwe.
Pogwiritsa ntchito munthawi yomweyo Simlo ndi ma immunosuppressants (cyclosporine), erythromycin, gemfibrozil, nicotinic acid, chiopsezo cha rhabdomyolysis ndi kulephera kwa impso kumawonjezeka. Ndi munthawi yomweyo kugwiritsa ntchito Simlo ndi yosalunjika anticoagulants, kuwonjezereka kwa pharmacological zochita zomalizirazi ndi zotheka. Ndi munthawi yomweyo kugwiritsa ntchito Simlo ndi colestyramine, bioavailability wa simvastatin amachepetsa (tikulimbikitsidwa kuti titenge Simlo maola 4 mutatenga colestyramine). Pogwiritsa ntchito munthawi yomweyo Simlo ndi digoxin, kuwonjezereka kwa anthu ena omaliza mwa plasma kumachitika.
Mosamala kwambiri, mankhwalawa amayenera kuperekedwa kwa odwala omwe amamwa mowa kwambiri komanso / kapena omwe ali ndi mbiri ya matenda a chiwindi. Mochenjera, mankhwalawa ayenera kutumizidwa kwa odwala pambuyo poti apatsidwa ma immunosuppressants, chifukwa chowonjezera cha rhabdomyolysis ndi kukula kwa aimpso kulephera. Ndi ochepa hypotension, pachimake matenda opatsirana, omwe ali ndi vuto lalikulu la metabolic, dongosolo la endocrine, kuchuluka kwa electrolyte, pakuchitika kwa maopaleshoni (kuphatikizapo mano) kapena kuvulala, mwa odwala ochepetsedwa kapena kuchuluka kwa minofu ya mafupa a etiology yosadziwika, ndi khunyu, mankhwalawa amatchulidwa mosamala, chifukwa matenda ndi mndandandandawo ungayambitse kusokonezeka kwa impso. Kuyang'anira ma labotale Pogwiritsa ntchito mankhwalawa, ndikofunikira kuyendetsa mafuta a plasma cholesterol. Kafukufuku woyamba amachitika pakatha masabata 4 atayamba mankhwalawa, ndiye kuwunikira chizindikiritso cha nthawi zonse uku. Asanachitike komanso atagwiritsa ntchito mankhwalawa, zomwe zimapezeka mu michere ya chiwindi ziyenera kuyang'aniridwa: m'miyezi itatu yoyambirira ya chithandizo, kuwunika kumachitika ndi masabata 6, kenako miyezi 6 iliyonse. Ndi kuwonjezeka kwa seramu transaminase milingo yochulukirapo katatu poyerekeza ndi magulu oyambira, chithandizo ndi Simlo ziyenera kusiyidwa. Pogwiritsa ntchito mankhwalawa, ndikofunikira kuwongolera kuchuluka kwa CPK mwa odwala omwe amalandira onse immunosuppressants kapena nicotinic acid, komanso myopathy (myalgia, kufooka kwa minofu). Ndi kuwonjezeka kwa mulingo wa CPK ochulukitsa nthawi 10 poyerekeza ndi zomwe zili bwino, mankhwalawa amayenera kusiyidwa.
Mankhwalawa amayenera kusungidwa pouma, kutetezedwa ndi kuwala, kufikira kwa ana pa kutentha osaposa 25 ° C. Moyo wa alumali ndi zaka 2. Mankhwalawa sayenera kugwiritsidwa ntchito atatha tsiku lotha ntchito lomwe likuwonekera phukusi. The zikuchokera mankhwalaPiritsi lirilonse la Simlo ndilophatikizika ndi makanema amtundu wina, ndipo ali ndi mawonekedwe awa: Zogwira pophika: simvastatin 10,000 mg
Chipolopolocho chimakhala ndi: hypromellose, tolk, titanium dioxide 0,520 mg, utoto wachikasu zachitsulo 0,002 mg, macrogol-400 0,20 mg., Iron oxide red oxide 0.038 mg. Piritsi lililonse la Simlo 20 mg lokhala ndi makina amakanema: Zogwira pophika: chigawo chimodzi simvastatin 20,000 mg.
Chipolopolo cha piritsi chimakhala ndi: talcum misa 1,040 mg, hypromellose kuchuluka kwa 2,400 mg, titanium dioxide mu 1,040 mg, utoto wazitsulo 0,036 mg, macrogol-400 0,240 mg, iron ironide utoto 0,044 mg.
Simlo akuwonetsedwa kuti agwiritse ntchito pazinthu zina:
Mawonekedwe ndi kipimoSimlo ndi mtundu wa mankhwala omwe ali ndi lipid-kuchepetsa. Limagwirira a achire zotsatira ndi zoletsa za enzymatic ntchito ya HMG-CoA reductase. Kutulutsa Fomu Simlo - makapisozi ndi mapiritsi, okhala ndi filimu pamwamba. Pamsika wathu wamankhwala pali mitundu itatu yosiyanasiyana - 5, 10 ndi 20 mg. Zogwira ntchito - simvastatin (simvastatin - malinga ndi radar - zotchulidwa mankhwala). Zowonjezera zomwe zimapanga piritsiyo: wowuma chimanga, ferrum oxide, 4-valent titanium oxide, microcrystalline ndi hydroxypropylmethyl cellulose, isopropanol, methylene chloride, citric acid monohydrate. Zotsatira zam'magazi chifukwa chogwiritsa ntchito simvastatin iyi zimagwirizanitsidwa ndi kuthekera kwake olepheretsa kupanga kwa cholesterol precursor ndi thupi. Chifukwa chake, atagwiritsidwa ntchito, pakuchepa kwa tizigawo ta mafuta m'magazi. Makamaka, kuchuluka kwa mafuta a triglycerides, LDL ndi VLDL, cholesterol yathunthu imachepa, kuchuluka kwa lipoproteins wina ndi mnzake kumakhala bwino, ndipo kuchuluka kwa cholesterol kwathunthu ndi zigawo zake (zomwe zili mu cholesterol ndi HDL ndizokhazikika). Zotsatira zochizira zimachitika masabata awiri atayamba kutenga Simlo. Peak wa mankhwalawa amachitika mu nthawi ya 4 mpaka sabata lachisanu ndi chimodzi kugwiritsa ntchito statin. Kuphatikiza apo, izi zimakhalabe panthawi ya mankhwalawa, komabe, pamene mankhwalawo atathetsedwa, chiwerengero cha lipid moyenera chibwereranso ku gawo loyambirira musanalandire mankhwala.
Njira zazikuluzikulu zothandizira zotsalira za mankhwalawa zimakhala ndi bile ndi impso. Ichi ndichifukwa chake, symlo sinafotokozeredwe matenda a impso ndi chiwindi mu gawo la mawonekedwe owopsa. Mukamagwiritsa ntchito simvastatin, ma plasma transaminases ndi CPK amayenera kuyang'aniridwa pafupipafupi. Kwa ma enzymes a hepatic plasma, kuphunzira koyamba kuyenera kuchitika milungu isanu ndi umodzi chiyambireni chithandizo. Zotsatira zoyipaNthawi zina, thupi la wodwalayo limapereka mayankho angapo pakugwiritsa ntchito symlo. Mawonetseredwe otsatirawa adadziwika chifukwa cha zovuta zomwe zingachitike:
Ngati muli ndi chimodzi mwazizindikiro zomwe zalembedwa pamwambapa, muyenera kufunsa dokotala ndipo, ngati pakufunika kutero, muchepetsani mankhwalawo, kapena musiyeni kugwiritsa ntchito mankhwalawo. Kuchita ndi mankhwala enaSimlo iyenera kuphatikizidwa mosamala ndi mankhwala monga fibrate (gemfibrozil), cyclosporine, niacin, erythromycin, ndi ena ofananitsa nawo. Pogwiritsidwa ntchito limodzi nawo, bioavailability ya mankhwala amawonjezeka, plasma ndende yawo imawonjezeka, chiwopsezo cha rhabdomyolysis chimayenda kangapo, ndikutsatira kulephera kwa aimpso, makamaka ndi ochepa hypotension. Akaphatikizidwa ndi anticoagulants, simvastatin imatha kuwongolera. Chisamaliro chapadera chiyenera kuperekedwa kwa odwala omwe ali ndi vuto la mtima omwe amalandila chithandizo chamtima glycosides - digoxin. Simvastatin imachulukitsa kuchuluka kwake kwa plasma, yomwe, chifukwa cha glycoside, imatha kupereka zovuta ku mtima wamagazi, imachulukitsa matenda a mtima. Analogs SimloMsika wathu wogulitsa mankhwala, Simlo statin ali ndi mitundu ingapo. Izi zikuphatikiza ndi zina zomwe zimagwira ntchito - Simvakard 10, 20, 40 mg, Simgal 10, 20 ndi 40 mg, Vasilip 10, 20 ndi 40 mg. Am'mbuyomu amaperekedwanso. malingana ndi mfundo zoyenera kuchitapo. Pano, mzere wa mankhwala oyamba komanso ma jenito ndi pafupifupi zopanda malire - kuchokera ku Atorvastatin, Torvakard, Atoris, Liprimar, Krestor, Holetar, Lipostat, Livazo ndi Rosucard. Onsewa ali ndi zotsatira za kuchepa kwa lipid ndipo ali m'gulu lalikulu la mankhwala - ma statins. Kugwiritsa Ntchito
Pavelko P.A. Kiev, wazaka 65, penshoni: Pafupifupi zaka zinayi zapitazo, adotolo adandiuza Simlo, chifukwa panali zopatuka zambiri kuchokera pa mbiri ya lipid. Momwe sindinganene motsimikiza, ndimakumbukira kuti panali cholesterol komanso ma triglycerides ambiri, pafupifupi kuwunikira konse kunakwezedwa. Tsopano tsiku lililonse ndimamwa piritsi ndi dongosolo lathanzi. Chomwe chimandisowetsa mtendere ndikuti tsopano moyo wanga wonse ndidzakhala pamatafura. Dokotalayo akuti nditha kusiya mankhwala ndi mankhwalawa, ndulu zonse zamafupa anga abwerere, motero ndiyenera kumwa pafupipafupi. ” Ndemanga za Simlo kuchokera kwa onse madokotala ndi odwala ali ndi zabwino zambiri. Izi zimachitika chifukwa cha mtengo wabwino kwambiri / chiwongola dzanja, chachitali, chofunikira kwambiri, komanso chofunikira, chachipambano pakugwiritsa ntchito mankhwalawa mankhwala. Ndi inhibitor yothandiza ya HMG-CoA reductase, imakhala yofalikira m'matangadza a mankhwala ndipo nthawi zambiri imabweretsa zotsatira zoyipa. Malangizo a mankhwalawaChigawo chilichonse cha mankhwala Simlo chimaphatikizapo malangizo kuvomerezeka. Malangizo a mankhwalawa ali ndi chidziwitso cha zomwe zikuwonetsa, mlingo woyenera, mavuto, contraindication, mawonekedwe omasulidwa, kapangidwe kake, zochita za bongo, njira yoyendetsera, momwe amalandirira panthawi ya pakati kapena poyamwitsa, malo osungirako, ndi moyo wa alumali. Kuphatikiza apo, palinso data pamtengo ndi mawonekedwe. PharmacologyMankhwala Simlo adapangidwa kuti azisinthasintha magawo amwazi. Mfundo pazotsatira za mankhwalawa Simlo zimakhazikitsidwa ndi kuthekera kwa chinthu chake chachikulu kupondereza kaphatikizidwe kazomwe zimayambira m'magazi a cholesterol omwe amapezeka m'chiwindi. Matenda a mapangidwe a biochemical ndi chimodzi mwazinthu zofunikira kwambiri zomwe zimachedwetsa kupitilira kwa atherosulinosis, komwe kumachepetsa mwayi wokhala ndi matenda a ischemic, komanso kupewa bwino maonekedwe a myocardial infarction. Mukamamwa, mankhwalawa amayamba kutsitsidwa m'mimba yaying'ono. Dziwani kuti magawo oyambira a mphamvu ya chinthu chogwira ntchito amapezeka m'matumbo a matumbo. Mukamadutsa m'chiwindi, zinthu zambiri zimasinthidwa ndikupanga zina. Chizindikiro chovomerezekaMankhwala tikulimbikitsidwa kuti ntchito:
Kulandila ndalamaYang'anani! Ngati ndi kotheka, dokotala angasinthe kuchuluka kwake.
Mankhwala sayenera kuperekedwa kwa wodwala osatinso kamodzi patsiku. Ngati ndi kotheka, onjezani kuchuluka kwa magazi kwa masabata anayi. Mlingo wovomerezeka womwe ungatengedwe patsiku ndi 40 mg. Chidacho chimaloledwa kutengedwa madzulo. Mwanjira imeneyi, mankhwalawa amatha kuledzera pakudya kapena pamaso pake. Kwa odwala omwe akulandira ma immunosuppressants, mlingo womwe umalimbikitsa ndi 5 mg tsiku lililonse. Odwala omwe ali ndi vuto lowonongeka la impso kapena loyenera, kusintha kwa mlingo sikofunikira. Ngati zotupa ndi zazikulu, ndiye kuti mlingo woyambirira suyenera kupitirira 5 mg patsiku. Pankhaniyi, ndikofunikira kwambiri kukayezetsa kuchipatala pafupipafupi. Ndi kuwonongeka pang'ono kwa chiwindi, kusintha kwa mankhwalanso sikufunikanso. Ngati kugonjetsedwa kwambiri, Simlo ayenera kukana kumwa mankhwalawo. Zochizira IHD, mankhwala amaperekedwa pa 10 mg. Kuchulukitsa kwa tsiku lililonse sikuyenera kupitilira nthawi imodzi. Mlingo wololedwa wambiri ukhale 10 mg. Kuphatikiza ndalama ndi mankhwala ena
Mukamayikidwa limodzi ndi ma anticoagulants osakhudzidwa, zotsatira zake zimatha kukula. Mukamamwa ndi cholesterol, bioavailability ya simvastatin imatsitsidwa. Ngati kumwa mankhwalawa kuli kofunikira, ndiye kuti Simlo ayenera kumwedwa maola 4 mutatha kudya cholestyramine. Mankhwala Simlo kangapo kumawonjezera kuchuluka kwa digoxin m'magazi a anthu. Zotsatira zoyipaNthawi zina thupi lomwe limakhudzidwa limatha kuyankha, lomwe limatha kudziwonetsa mwa wodwala mu mawonekedwe a zizindikiro monga:
Ngati zizindikirozi zikuyamba kuonekera, dziwitsani adokotala nthawi yomweyo. Pa nthawi yoyembekezeraMankhwalawa sayenera kumwedwa panthawi yoyembekezera kapena yoyamwitsa, monga zotsatira zosakonzekera zitha kuyamba kukhazikika mwa mwana.
Chipinda chino chizikhala chotentha kokwanira, chozizira, komanso chamdima. Mankhwala ayenera kusungidwa kutali ndi ana ndi nyama zomwe amakonda. Malinga ndi malingaliro onse, malonda angagwiritsidwe ntchito kwa zaka ziwiri. Mankhwala omwe atha ntchito saloledwa kuti atenge, chifukwa chida choterechi chimangovulaza thupi lanu lomwe lakhudzidwa kale. Kutengera dera, mtengo wake umatha kusiyanasiyana. Ku Russia mtengo umachokera ku 275 mpaka 390 rubles. Ku Ukraine mtengo unakhazikitsidwa ku 198, 57 hryvnia. Pakati pazofanizira za chida ichi, ndizotheka kusiyanitsa mankhwala monga Vazilip, Zovatin, Zokor, Levomir, Ovenkor, Simvakol, Simvastol, Simvagestal, Holvasim, Simplakor, Simvakard, Holvasim, Simvor, Sinkard, Simplakor, Simgal, komanso njira zina. Popereka analogue, dokotalayo ayenera kuganizira mphamvu za wodwalayo, momwe alili, komanso momwe angathandizire zigawo zina. Mwa zabwino, mndandanda wambiri wa ofanana ungathe kusiyanitsidwa. Kuphatikiza apo, ambiri amasiyananso njira yosavuta yoyendetsera, komanso mtengo wotsika mtengo. Mwakukula, odwala akuphatikizira kukhalapo kwa contraindication ndi zoyipa. Zotsatira zoyipaKuchokera pamatumbo: dyspepsia (nseru, kusanza, m'mimba, kupweteka kwam'mimba, kudzimbidwa kapena kutsekula m'mimba, chiwindi, jaundice, kuchuluka kwa "chiwindi" transaminases ndi alkaline phosphatase, CPK, kawirikawiri - pachimake pancreatitis. Kuchokera kwamankhwala amanjenje ndi ziwalo zam'magazi: asthenia, chizungulire, kupweteka mutu, kusowa tulo, kupweteka, paresthesias, zotumphukira zamitsempha, mawonekedwe osasinthika, kusokonekera kwa zomverera. Kuchokera ku minculoskeletal system: myopathy, myalgia, myasthenia gravis, kawirikawiri rhabdomyolysis. Thupi lawo siligwirizana ndi immunopathological: angioedema, lupus ngati matenda, polymyalgia rheumatism, vasculitis, thrombocytopenia, eosinophilia, kuchuluka kwa ESR, nyamakazi, arthralgia, urticaria, photosensitivity, fever, hyperemia ya pakhungu. Dermatological zimachitika: zotupa pakhungu, kuyabwa, alopecia. Zina: kuchepa kwa magazi m'thupi, palpitations, kulephera kwa impso (chifukwa cha rhabdomyolysis), kutsika kwa potency. Malangizo apaderaMusanayambe chithandizo, ndikofunikira kuti muwoneke momwe chiwindi chimagwirira ntchito (kuwunika momwe "chiwindi" chikufikirira masabata 6 aliwonse kwa miyezi itatu yoyambirira, kenako milungu isanu ndi itatu ya chaka chotsalira, komanso kamodzi miyezi isanu ndi umodzi). Kwa odwala omwe amalandila simvastatin tsiku lililonse la 80 mg, chiwindi chimayang'aniridwa kamodzi miyezi itatu iliyonse. Milandu yomwe ntchito ya "chiwindi" transaminases imachulukana (kuchulukitsa katatu pazomwe zimachitika), chithandizo chimathetsedwa. Odwala a myalgia, myasthenia gravis ndi / kapena kuwonjezeka kodziwika ka zochitika za CPK, mankhwala osokoneza bongo amayimitsidwa. Simvastatin (komanso zoletsa zina za HMG-CoA reductase inhibitors) siziyenera kugwiritsidwa ntchito ndi chiwopsezo chowonjezeka cha matenda a rhabdomyolysis ndi kulephera kwa aimpso (chifukwa cha kufooka kwambiri, kuchepa kwa mitsempha, opaleshoni yayikulu, kuvulala kwambiri, komanso kuvulala kwambiri kwa metabolic. Kuletsa lipid-kuchepetsa mankhwala panthawi yoyembekezera sikukhudza kwambiri zotsatira za chithandizo cha nthawi yayitali cha hypercholesterolemia. Chifukwa chakuti HMG-CoA reductase inhibitors inhibit cholesterol synthesis, ndi cholesterol ndi zinthu zina zomwe zimapangidwa zimathandizira kwambiri kukulira kwa mwana wosabadwayo, kuphatikizapo kuphatikiza kwa ma steroid ndi nembanemba yama cell, simvastatin imatha kukhala ndi vuto pa mwana wosabadwayo azimayi a msinkhu wobereka azitsatira mosamala njira zakulera). Mimba ikachitika panthawi ya chithandizo, mankhwalawo ayenera kusiyidwa, ndipo mayiyo anachenjeza za ngozi yomwe ingakhalepo kwa mwana wosabadwayo. Simvastatin siimawonetsedwa pomwe pali mtundu I, IV, ndi V hypertriglyceridemia. Imagwira bwino onse mu mawonekedwe a monotherapy, komanso osakanikirana ndi bile acid. Asanachitike komanso munthawi yamankhwala, wodwalayo ayenera kukhala ndi chakudya cha hypocholesterol. Pakusowa mlingo womwe ulipo, mankhwalawa amayenera kumwedwa posachedwa. Ngati ili nthawi yotsatira, musangonenepa. Odwala kwambiri aimpso kulephera, mankhwala ikuchitika motsogozedwa aimpso. Odwala amalangizidwa kuti afotokozereni ululu wosaneneka wa minofu, kufooka, kapena kufooka, makamaka ngati kumayendera limodzi ndi malaise kapena kutentha thupi. Ndi chisamaliroOdwala omwe ali ndi vuto la uchidakwa komanso odwala omwe adagwidwa ndi ziwalo zina akulangizidwa kuti azichita mosamala kwambiri ndi Simlo.
Simlo iyeneranso kutengedwa mosamala ndi odwala omwe ali ndi mafupa am'mimba osinthika, okhala ndi khunyu kapena kugwidwa kosalamulirika. Pamaso pa chilichonse mwa mindandanda, tikulimbikitsidwa kumwa mankhwalawa pokhapokha ngati akuwuzani dokotala.
|
Zolemba za Pharmacokinetic zimaphatikizira kuyamwa kwambiri kwa mucous m'mimba mukamamwa. Biotransformation ndi kagayidwe ka simlo limachitika m'chiwindi. Ma metabolites omwe amagwira ntchito amapangidwapo, omwe ndi beta-hydroxymetabolites. Kufikira 95% ya iwo amamangiriza ku mapuloteni amwazi.
Ndi hypercholesterolemia, mlingo woyambirira suyenera kupitirira 5 mg / tsiku. Ndi kulumpha mwamphamvu mu cholesterol m'magazi, mankhwala amapatsidwa mlingo wa 10 mg.
Ndi munthawi yomweyo makonzedwe a Simplo ndi cyclosporine, gemfibrozil, erythromycin kapena nicotinic acid, chiopsezo cha rhabdomyolysis chimawonjezeka kangapo.
Mankhwalawa amayenera kuikidwa pamalo omwe kutentha sudzapitirira 25 digiri.
