Mtundu Wachiwiri wa Matenda a shuga Atha Kuletsa Kuyenda Kwa Matenda a Parkinson

Chaka chatha, gulu lochokera ku Yunivesite ya Netherlands lidapeza zomwe zidagwirizana ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda osokoneza bongo. Tikuyankhula za kuthekera kwa kayendetsedwe kake m'matenda a Parkinson komanso zabwino za mankhwalawa. Mankhwalawa ndi a gulu la ma incretin mimetics, omwe ali chinthu chatsopano pakupanga mankhwala. Idamasulidwa zaka zisanu zapitazo. Thupi lake lalikulu limasungidwa ku poizoni wa buluzi - wotchedwa Arizona puffer.

Zaka zinayi pambuyo pake, zomwe zidagwiritsidwa ntchito pophunzira ntchito ya poiziyi, kuiwongolera ndikuyesa, chinthu chomwe chidagwira ntchito chidadziwika kuti ndi chothandiza ndikupereka exenatide - mankhwala atsopano osagwirizana ndi matenda a shuga.

Pafupifupi nthawi yomweyo, magulu ena a asayansi adatha kutsimikizira kuti matenda a Parkinson amayamba m'matumbo, kenako ubongo umatha kulowa. Ngakhale pali zizindikiro zosiyana kwambiri m'matenda awiriwa, matendawa ali ndi machitidwe ofanana pamaselo. Popeza chatsopanocho chimayendetsa ntchito ya mitochondrial m'maselo aubongo ndikubwezeretsa kuthekera kwa maselo kusintha michere yofunika kukhala mphamvu, madotolo adaganiza kuti odwala omwe apezeka ndi matenda a Parkinson adzakumana ndi kuthekera kwa kuthekera kwawo pakupanga mapuloteni owopsa. Chifukwa chake, kutupa kudzachepetsedwa, ndipo kufa kwa ma neuron kudzachepetsedwa.

Pambuyo pa malingaliro awa atafotokozedwa, adayesa mayesero azachipatala. Zotsatira zake, asayansi adatha kutsimikizira kuchuluka kwa mankhwalawa polimbana ndi matenda a Parkinson. Mayeso azachipatala adachitika ku UK.

Kugwirizana

Odwala omwe ali ndi matenda a Parkinson, pamakhala kuwonongeka pang'onopang'ono kwa maselo aubongo omwe amapanga dopamine ya mahomoni, chifukwa chomwe kunjenjemera kumayamba, zovuta pakuyenda komanso zovuta kukumbukira.

Mankhwala onse omwe alipo pano amathandizira kuchepetsa zizindikiro, koma sangathe kuletsa kufa kwa maselo a muubongo.

Mu chipinda chimodzi, chosasinthika, chakhungu chakumaso, chowongolera malo, odwala omwe ali ndi zaka 25-75 omwe ali ndi matenda a idiopathic Parkinson adaphatikizidwa. Kuopsa kwa matendawa kunadziwika chifukwa cha njira ya Queen Square Brain Bank ndipo odwala onse anali ndi gawo 2-5 molingana ndi Hoehn ndi Yahr panthawi ya dopaminergic.

Odwala adasinthidwa mwachisawawa 1: 1 kwa gulu la majakisoni amkati a exenatide (an glucagon-like peptide-1 analogue) 2 mg kapena placebo 1 sabata iliyonse kwa masabata 48 kuwonjezera pa chithandizo chamankhwala. Nthawi yamankhwala idatsatiridwa ndi kupuma kwa milungu 12.

Zosintha mu Movement Disways Social Unified Parkinson's Disease Rating Scale (MDS-UPDRS) sabata la 60 (vuto laling'ono la caloric) zinagwiritsidwa ntchito ngati njira yayikulu yothandiza.

Zotsatira

Kuyambira mu Juni 2014, lipid ya 2015 idaphatikizapo odwala 62 pakuwunika, 32 mwa iwo adaphatikizidwa m'gulu la Exexenatide ndi 30 pagulu la placebo. Kusanthula koyenerera kunaphatikizapo odwala 31 ndi 29, motsatana.

• Sabata 60, panali kuwongolera kwa subscale of motor kukomoka kwa MDS-UPDRS pamlingo wa 1.0 point (95% CI −2.6 - 0.7) mu gulu la exenatide, poyerekeza ndikuipiraipira kwa mfundo za 2.1 (95% CI −0, 6 - 4.8) pagulu lolamulira, kusiyana kosinthika kwapakati pamagulu, −3.5 mfundo (95% CI −6.7 - −0.3, p = 0.0318).
• Zochitika zoyipa kwambiri m'magulu onse awiriwa ndizotsatira za jakisoni ndi zizindikiro zam'mimba. Zotsatira zoyipa 6 zidalembedwa mwa odwala a gulu lawo lalikulu, poyerekeza ndi 2 kuchokera pakulamulira, koma palibe omwe adawonedwa kuti akuphatikizidwa ndi phunziroli.

Pomaliza

Exenatide imathandizira kwambiri kuwonongeka kwa mota mwa odwala omwe ali ndi matenda a Parkinson. Nthawi yomweyo, sizikudziwika ngati mankhwalawa amakhudza njira zamatenda kapena zimangokhala ndi chizindikiro chosakhalitsa. Ngakhale kuthekera kwa exenatide, kufufuza kwina ndikofunikira, kuphatikiza ndi nthawi yayitali yowonera.

Source:
Dilan Athauda, ​​Kate Maclagan, Simon S Skene, et al. MLachida. 03 Ogasiti 2017.