Acetylsalicylic Acid MS

Rheumatism, nyamakazi yamatenda am'mimba, matenda opha ziwongo, pericarditis, rheumatic chorea - sagwiritsidwa ntchito pano.

Feverish syndrome mu matenda opatsirana komanso kutupa.

Ululu syndrome (wamavuto osiyanasiyana): mutu (kuphatikizira omwe amagwirizana ndi kusiya mowa), migraine, mano, neuralgia, lumbago, radicular radicular syndrome, myalgia, arthralgia, algodismenorea.

Monga antiplatelet mankhwala (Mlingo mpaka 300 mg / tsiku): matenda a mtima, kukhalapo kwa zinthu zingapo zomwe zingayambitse matenda a mtima, kupweteka kwa myocardial ischemia, kusakhazikika kwa angina pectoris, myocardial infarction (kuchepetsa chiopsezo chobwereranso myocardial infarction ndi kufa pambuyo pa myocardial infaration sitiroko amuna, ma cell ma cell ochita ma cell (kupewa ndi kuchiza matenda a thromboembolism), balloon coronary angioplasty ndi kuyikika kolimba (kuchepetsa chiopsezo cha kubwezeretsanso stenosis ndi chithandizo cha stratation yachiwiri ya mtsempha wamagazi), ndi ma atheros klerotic zotupa za coronary artery (matenda a Kawasaki), aortoarteritis (matenda a Takayasu), mavuvu ya mitsempha ya mtima ndi mawonekedwe a fibrillation, mitral valve prolapse (kupewa thromboembolism), pulmonary embolism, pulmonary infarction, pachimake thrombophlebitis,

Mu matenda immunology ndi allergology: mu kukula pang'onopang'ono Mlingo wa "aspirin" wokhalitsa komanso mapangidwe okhazikika a NSAIDs mwa odwala omwe ali ndi "Asipirin" mphumu ndi "aspirin triad".

Contraindication

Hypersensitivity, kukokoloka ndi zilonda zam'mimba zam'matumbo (mu pachimake gawo), kutulutsa magazi m'mimba, "aspirin" triad (kuphatikiza mphumu ya bronchial, kupezekanso kwa polyposis ya mphuno ndi paranasal sinuses komanso tsankho kwa ASA ndi mankhwala a pyrazolone hemophilia, hemorrume hemorrhea. telangiectasias, hypoprothrombinemia, thrombocytopenic, thrombocytopenic purpura), dissecting aortic aneurysm, portal matenda oopsa, kusowa kwa vitamini K, chiwindi / impso, kulephera (I ndi III chepetsa Stryi), mkaka wa m'mawere, alibe shuga-6-mankwala dehydrogenase, zaka ana (mpaka zaka 15 - chiopsezo syndrome Reye ya ana ndi hyperthermia pa maziko a matenda tizilombo) .C mosamala. Hyperuricemia, mkodzo nephrourolithiasis, gout, chiwindi, zilonda zam'mimba komanso / kapena duodenal ulcer (mbiri), kuwonongeka kwa mtima.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mapiritsi osungunuka: mkati, omwe adasungunuka pang'ono m'madzi pang'ono, 400-800 mg katatu patsiku (osaposa 6 g). Mu rheumatism pachimake - 100 mg / kg / tsiku mu 5-6 waukulu.

Mapiritsi okhala ndi ASA mu Mlingo pamwambapa 325 mg (400-500 mg) adapangidwa kuti agwiritsidwe ntchito ngati mankhwala a analgesic komanso anti-kutupa, mu Mlingo wa 50-75-100-300-325 mg mwa akulu, makamaka ngati mankhwala a antiplatelet.

Mkati, wokhala ndi febrile ndi ululu matenda, akulu - 0,5-1 g / tsiku (mpaka 3 g), logawidwa 3 waukulu. Kutalika kwa chithandizo sikuyenera kupitilira masabata awiri.

Mapiritsi a Mphamvu ya Mphamvuyi amasungunuka mu 100-200 ml ya madzi ndikuwamwa pakumwa, kumwa kamodzi - 0,25-1 g, kumwedwa katatu patsiku. Kutalika kwa mankhwalawa - kuchokera pa mlingo umodzi kupita kumaphunziro a miyezi yambiri.

Kusintha rheological katundu wamagazi - 0,15-0.25 g / tsiku kwa miyezi ingapo.

Ndi myocardial infarction, komanso kupewa kwachiwiri kwa odwala pambuyo poyambira infarction, 40-325 mg kamodzi patsiku (nthawi zambiri 160 mg). Monga zoletsa za kuphatikiza kwa maselo am'magazi - 300-325 mg / tsiku kwa nthawi yayitali. Ndi kusokonezeka kwa mphamvu ya cerebrovascular in men, ubongo wa thromboembolism - 325 mg / tsiku ndi kuwonjezeka pang'onopang'ono mpaka 1 1 / tsiku, kupewa kupewa kuyambiranso - 125-300 mg / tsiku. Pofuna kupewa thrombosis kapena kung'ambika kwa aortic shunt, 325 mg maola 7 aliwonse kudzera mu chubu cham'mimba, ndiye kuti 325 mg pamlomo katatu katatu patsiku (nthawi zambiri amaphatikizidwa ndi dipyridamole, yemwe amathetsedwa pakatha sabata, akupitilira chithandizo chanthawi yayitali ndi ASA.

Ndi rheumatism yogwira imalembedwa (pakadali pano yopanda mankhwala) tsiku lililonse la 5-8 g kwa achikulire ndi 100-125 mg / kg kwa achinyamata (zaka 15-18), pafupipafupi kugwiritsa ntchito 4-5 pa tsiku. Pambuyo pa chithandizo cha milungu iwiri kapena itatu, ana amachepetsa mlingo mpaka 60-70 mg / kg / tsiku, chithandizo chachikulire chimapitilizidwa pa mlingo womwewo, nthawi yayitali yauchipatala imakhala mpaka masabata 6. Kuletsa kumachitika pang'onopang'ono mkati mwa masabata 1-2.

Zotsatira za pharmacological

NSAIDs ali ndi anti-yotupa, analgesic ndi antipyretic zotsatira zolumikizana ndi zosasiyanitsa zochitika za COX1 ndi COX2, zomwe zimayang'anira kapangidwe ka Pg. Zotsatira zake, Pg siinapangidwe, imapereka mapangidwe a edema ndi hyperalgesia. Kuchepa kwa zomwe zili ndi Pg (makamaka E1) pakatikati pa thermoregulation kumabweretsa kuchepa kwa kutentha kwa thupi chifukwa cha kuchuluka kwa mitsempha ya magazi pakhungu komanso thukuta lomwe likuwonjezeka.

Mphamvu ya analgesic imachitika chifukwa cha zonse zapakati komanso zotumphukira.

Amachepetsa kusakanikirana, kuphatikizika kwa mapulateleti ndi thrombosis poletsa kaphatikizidwe ka thromboxane A2 mu mapulosi. Mphamvu ya antiplatelet imapitirira masiku 7 pambuyo pa limodzi lokha (lotchulidwa kwambiri mwa amuna kuposa akazi). Imachepetsa kufa ndi chiopsezo chokhala ndi myocardial infaration ndi angina osakhazikika. Imathandizanso kupewa kupewetsa matenda a CVD, makamaka kulowetsedwa kwam'matumbo mwa amuna okulirapo zaka 40, komanso kupewa kwachiwiri kwa kulowetsedwa kwa myocardial.

Mlingo wa tsiku lililonse wa 6 g kapena kuposerapo, umalepheretsa kaphatikizidwe ka prothrombin mu chiwindi ndikuwonjezera nthawi ya prothrombin.

Kuchulukitsa kwa plasma fibrinolytic ntchito ndikuchepetsa kuchuluka kwa mavitamini obwera chifukwa cha vitamini K (II, VII, IX, X). Zimawonjezera zovuta za hemorrhagic panthawi yopangira opaleshoni, zimawonjezera chiopsezo chotaya magazi munthawi ya mankhwala ndi anticoagulants.

Imathandizira kuchulukitsidwa kwa uric acid (imasokoneza kuyambiranso kwa impso), koma yayikulu.

Kubisa kwa COX1 m'matumbo a mucosa kumabweretsa kuyimitsidwa kwa gastroprotective Pg, komwe kungayambitse zilonda zamkati ndi mucous pambuyo pake. Zosasangalatsa zomwe zimakhumudwitsa mucous membrane wa m'mimba ndi mitundu ya mankhwala omwe ali ndi buffer zinthu, chovala chovomerezeka, komanso mitundu yapadera ya "mapangidwe" a mapiritsi.

Zotsatira zoyipa

Kuchepetsa mphuno, kuchepa kwa chilala, gastralgia, kutsegula m'mimba, matupi awo a khungu (zotupa pakhungu, angioedema, bronchospasm), chiwindi ndi / kapena ntchito ya impso, thrombocytopenia, kuchepa magazi, leukopenia, Reye matenda (encephalopathy ndi pachimake mafuta a chiwindi matenda otupa chiwindi kulephera) , mapangidwe pamaziko a hapten limagwirira "mphumu" ndi "aspirin triad" (kuphatikiza mphumu ya bronchial, kuphatikizanso kwa polyposis ya mphuno ndi zolakwika za paranasal komanso kusalolera kwa ASA ndi mankhwala a pyrazolone mndandanda.

Ndi kugwiritsa ntchito kwa nthawi yayitali - chizungulire, kupweteka mutu, kusanza, zotupa ndi zotupa zam'mimba, kuchuluka kwa magazi, kutulutsa magazi (kuphatikizapo m'mimba thirakiti), kuwonongeka kwa m'maso, kumva makutu, tinnitus, bronchospasm, interstitial nephritis, kuchuluka kwa azotemia magazi a creatinine ndi hypercalcemia, papillary necrosis, kulephera kwa impso, nephrotic syndrome, aseptic meningitis, kuchuluka kwa kulephera kwa mtima, edema, kuchuluka kwa "hepatic" transaminases. Zizindikiro (mlingo umodzi wochepera 150 mg / kg - poyizoni wamphamvu amaonedwa kuti ndi wofatsa, 150-300 mg / kg - odziletsa, oposa 300 mg / kg - woipa): salicylism syndrome (nseru, kusanza, tinnitus, kusawona bwino, chizungulire, kwambiri kupweteka kwa mutu, malaise, kutentha thupi - chizindikiro chazosautsa cha achikulire). Zambiri poizoni - Hyperventilation m'mapapo apakati chiyambi, kupuma zamkati, kagayidwe kachakudya acidosis, kusokonezeka chikumbumtima, kugona, kugwa, zopweteka, magazi, magazi. Poyamba, kuphatikiza kwapakati pa mapapo kumabweretsa kupuma kwamatumbo - kufupika, kupuma, cyanosis, kuzizira, thukuta, komanso kuchuluka kwa kuledzera, kupuma ziwalo ndi kudzipatula kwa oxosative phosphorylation, kuchititsa kupuma kwa acidosis.

Matenda osokoneza bongo osaneneka, kuchuluka kwa plasma sikugwirizana bwino ndi kuopsa kwa kuledzera. Chiwopsezo chachikulu chotenga kuledzera kosatha chimawonedwa mwa okalamba omwe ali ndi mlingo woposa 100 mg / kg / tsiku kwa masiku angapo. Mwa ana ndi odwala okalamba, zizindikiritso zoyambirira za salicylism sizidziwika nthawi zonse, chifukwa chake, ndikofunika kuti nthawi ndi nthawi muzindikire kuchuluka kwa ma salicylates m'magazi: mulingo woposa 70 mg% umawonetsa poizoni wambiri kapena woopsa, woposa 100 mg% - woopsa, wosavomerezeka. Poizoni wowonda, kuchipatala kumafunika maola 24.

Chithandizo: kuyambitsa kusanza, kuikidwa kwa makala okhazikika ndi mankhwala othandizira, kuyang'anira mosamalitsa kwa BOC ndi electrolyte bwino, kutengera mtundu wa kagayidwe - kuyambitsa sodium bicarbonate, sodium citrate kapena sodium lactate. Kuwonjezeka kwa mchere wamchere kumathandizira kuchotsedwa kwa ASA chifukwa cha mkodzo wa mkodzo. Urine alkalization imawonetsedwa kwa salicylates pamtunda wa 40 mg% ndipo imaperekedwa ndi iv kulowetsedwa kwa sodium bicarbonate (88 mEq mu 1 l peresenti ya 5% dextrose solution, pamlingo wa 10-15 ml / h / kg), kubwezeretsanso kwa bcc, ndi kuyambitsa kwa diuresis kumatheka poyambitsa sodium bicarbonate Mlingo womwewo ndi zakumwa zomwezo, zomwe zimabwerezedwa kawiri kawiri. Chenjezo liyenera kuchitidwa mwa okalamba omwe omwe kulowetsedwa kwambiri kwamadzimadzi angayambitse mapapu. Kugwiritsa ntchito acetazolamide kwa mkodzo wa mkodzo sikulimbikitsidwa (kungayambitse acidemia ndikuwonjezera poizoni wa salicylates). Hemodialysis amasonyezedwa salicylates oposa 100-130 mg%, mwa odwala poyizoni - 40 mg% kapena kuchepera ngati akuwonetsedwa (Refractory acidosis, kuwonongeka kwapang'onopang'ono, kuwonongeka kwakatundu kwamkati wamanjenje, pulmonary edema ndi kulephera kwa aimpso. Ndi pulmonary edema, makina mpweya wabwino wolemera ndi mpweya.

Malangizo apadera

Kutalika kwa mankhwalawa (popanda kufunsa dokotala) sikuyenera kupitirira masiku 7 mutagwiritsidwa ntchito ngati mankhwala a analgesic komanso masiku oposa 3 monga antipyretic.

Pakadali pano, kugwiritsa ntchito ASA ngati mankhwala othana ndi kutupa tsiku lililonse mlingo wa 5-8 g ndiwocheperako chifukwa cha zovuta zambiri zoyipa kuchokera ku m'mimba thirakiti (NSAID gastropathy).

Musanachite opareshoni, kuti muchepetse magazi munthawi ya opaleshoni komanso munthawi yothandizira, muyenera kusiya kumwa salicylates kwa masiku 5-7 ndikuuza dokotala.

Pa chithandizo cha nthawi yayitali, kuyezetsa magazi ndi kuyeseza kochita zamatsenga kozizwitsa kuyenera kuchitidwa.

Ana sayenera kupatsidwa mankhwala okhala ndi ASA, popeza povutikira kachilombo, amatha kuwonjezera ngozi ya matenda a Reye. Zizindikiro za Reye's syndrome zimaphatikizapo kusanza kwa nthawi yayitali, encephalopathy, komanso chiwindi.

Kukhazikitsidwa kwa mapiritsi mukatha kudya, kupera kwawo mokwanira, kugwiritsa ntchito mapiritsi okhala ndi zowonjezera kapena zokutira ndi kuphatikiza kwapadera kwa enteric, komanso kugwiritsa ntchito munthawi yomweyo mankhwala omwe amalepheretsa acidity ya madzi a m'mimba, kuchepetsa kupweteketsa mtima pamimba.

Imakhala ndi teratogenic, ikagwiritsidwa ntchito mu trimester yoyamba, imayambitsa kukulitsa kwa palate yapamwamba, mu trimester yachitatu imayambitsa kulepheretsa kwa ntchito (inhibition of Pg synthesis), kutsekeka msanga kwa ductus arteriosus mu fetus, pulmonary vascular hyperplasia ndi kufalikira kwa magazi m'thupi. Imafukusidwa mkaka wa m'mawere, zomwe zimapangitsa kuti magazi azituluka kwa mwana chifukwa chazunguzi.

ASA ngakhale yaying'ono Mlingo amachepetsa excretion wa uric acid mthupi, zomwe zingachititse kuti chiwopsezo cha gout odwala atengeke.

Pa nthawi ya mankhwala sayenera kumwa Mowa.

Kuchita

Imawonjezera kuwopsa kwa methotrexate, kuchepetsa kufalikira kwa impso, zotsatira za ena a NSAIDs, narcotic analgesics, pakamwa hypoglycemic mankhwala, reserpine, heparin, yosalunjika anticoagulants, thrombolytics ndi mapulateni ovomerezeka, sulfonamides (kuphatikizapo mphamvu ya co-trim 3). uricosuric mankhwala (benzbromarone, sulfinpyrazone), antihypertensive mankhwala, okodzetsa (spironolactone, furosemide).

GCS, ethanol ndi mankhwala okhala ndi ethanol amathandizira kuti awonongeke m'matumbo am'mimba, achulukitse magazi.

Kuchulukitsa kuchuluka kwa digoxin, barbiturates, ndi Li + salt mu plasma.

Ma antacid okhala ndi Mg2 + ndi / kapena Al3 + amachepetsa ndikuletsa mayendedwe a ASA.

Mankhwala a Myelotoxic amathandizira kuwonetsa kwa hematotoxicity ya mankhwalawa.

Kugwiritsa ntchito acetylsalicylic acid MS pa mimba ndi mkaka wa m`mawere

Contraindised mu I ndi III trimesters a mimba. Mu II trimester yokhala ndi pakati, kuvomereza kamodzi ndikotheka malinga ndi mawonekedwe okhwima.

Imakhala ndi teratogenic: ikagwiritsidwa ntchito mu trimester yoyamba, imayambitsa kukulira kwa palate yapamwamba, mu trimester yachitatu yomwe imayambitsa kulepheretsa kwa ntchito (inhibition of prostaglandin synthesis), kutsekeka msanga kwa ductus arteriosus mu fetus, pulmonary vascular hyperplasia ndi kufalitsa kwamatumbo m'magazi.

Acetylsalicylic acid imachotseredwa mkaka wa m'mawere, zomwe zimapangitsa kuti magazi azituluka kwa mwana chifukwa cha kuphwanya mapindikidwe am'magazi, chifukwa chake, amayi sayenera kugwiritsa ntchito acetylsalicylic acid pa mkaka wa mkaka.

NSAIDs. Imakhala ndi zotsutsana ndi kutupa, ma analgesic ndi antipyretic zotsatira, komanso imalepheretsa kuphatikiza kwa mapulateleti. Kupanga kwamachitidwe kumalumikizidwa ndi kulepheretsa kwa ntchito ya COX - njira yofunika kwambiri ya kagayidwe ka arachidonic acid, yomwe ili patsogolo pa prostaglandins, yomwe imagwira gawo lalikulu pathogenesis ya kutupa, kupweteka ndi kutentha thupi. Kutsika kwa zomwe zili mu ma prostaglandins (makamaka E 1) pakatikati pa thermoregulation kumabweretsa kuchepa kwa kutentha kwa thupi chifukwa cha kuchuluka kwa mitsempha ya magazi pakhungu komanso thukuta lomwe likuwonjezeka. Mphamvu ya analgesic imachitika chifukwa cha zonse zapakati komanso zotumphukira. Amachepetsa kusakanikirana, kuphatikizika kwa mapulateleti ndi thrombosis poletsa kaphatikizidwe ka thromboxane A 2 m'maselo.

Imachepetsa kufa ndi chiopsezo chokhala ndi myocardial infaration ndi angina osakhazikika. Kugwiritsa ntchito yoyambirira kupewa matenda a mtima dongosolo ndi yachiwiri kupewa myocardial infarction. Mlingo wa tsiku lililonse wa 6 g kapena kuposerapo, umalepheretsa kaphatikizidwe ka prothrombin mu chiwindi ndikuwonjezera nthawi ya prothrombin. Kuchulukitsa kwa plasma fibrinolytic ntchito ndikuchepetsa kuchuluka kwa mavitamini obwera chifukwa cha vitamini K (II, VII, IX, X). Zimawonjezera zovuta za hemorrhagic panthawi yopangira opaleshoni, zimawonjezera chiopsezo chotaya magazi munthawi ya mankhwala ndi anticoagulants. Imathandizira kupukusika kwa uric acid (imasokoneza kuyambiranso kwa impso tubules), koma muyezo waukulu. Blockade ya COX-1 m'mimba mucosa kumabweretsa zoletsa gastroprotective prostaglandins, zomwe zingayambitse zilonda zam'mimba mucous ndi magazi pambuyo pake.

Zina

Mankhwala ndi mankhwala omwe amachotsa njira zotupa.Chofunikira chachikulu pa mankhwalawa ndi aspirin, yemwe ali ndi zotsatira zosiyanasiyana. Chofunikira kwambiri ndi asidi amene amatulutsidwa ku msondodzi woyera. Khungwa la mtengowo lidagwiritsidwa ntchito ngati mankhwala mankhwala zaka zambiri zapitazo. Mu 1838, ku Italy, Rafael Piria wopanga mankhwala anapanga salicylic acid. Koma kumayambiriro kwa Ogasiti 1897 ku Germany, katswiri ku Bayer AG adagwiritsa ntchito njira ya acetylation ku acid, motero amapanga asidi acetylsalicylic acid. Dzina lake anali Felix Hoffman. Komabe dzina la malonda akuti Aspirin ndi la kampani iyi yaku Germany.

Kupanga ndi mawonekedwe a kumasulidwa

Kapangidwe ka mankhwala kamaphatikizira izi:

• acetylsalicylic acid
• wowuma mbatata
• talcum ufa
• shuga mkaka
• polyvinylpyrrolidone wochepa maselo
• stearic acid.

Chogulikacho chimapezeka m'mapiritsi oyera okhala ndi mbali zokutidwa ndi mawonekedwe. Kumbali imodzi ya mapiritsi ndi chizindikiro cholekanitsa. Mapiritsiwo amaikidwa m'matumba awiri, chilichonse chimakhala ndi zidutswa khumi. Matumba ali m'mabokosi a makatoni ndi malangizo ogwiritsa ntchito.

Mankhwala

Kugwiritsa ntchito acetylsalicylic acid MS kumasonyezedwa kupweteka, kutentha thupi, kutupa. Ili ndi zotsatira zabwino, monga COX inhibitor. Thupi limachepetsa kuchuluka kwa ma enzymes, kupewa kupangidwe kwamafuta a polyunsaturated mafuta, omwe, amathandizira kukulitsa kutupa. Komanso, aspirin imapangitsa capillaries kukhala yovomerezeka, imachepetsa ntchito za ma enzymes omwe amachititsa kuti asidi achulukane mucopolysaccharides, komanso amachepetsa mawonekedwe a ATP.

Thupi limalowetsedwa kwathunthu m'thupi. Kuchita bwino kwambiri kumachitika pambuyo pa mphindi 120. Imafalikira mwachangu mthupi lonse, kulowa m'mafupa, chithokomiro cha mafupa, ndi zina zotere. Imapakidwa limodzi ndi mkodzo mkati mwa 60% ya Mlingo wovomerezeka. Osachepera theka moyo ndi maola 2, pomwe pazovuta nthawi zina amafika maola 30.

Chizindikiro chomwera mankhwalawa chimatha kukhala mndandanda wamatenda ambiri, kuphatikizapo:

• mankhwala a mitundu yosiyanasiyana ya ululu (mutu, dzino, minofu ndi mafupa, olowa),
• kuphwanya kwamphamvu kutentha kwa thupi (ARVI, ARI ndi kutupa, kukhala ndi matenda opatsirana),
• zolakwika mu kugwira ntchito kwa mtima dongosolo (ischemia, kugunda kwa mtima, kusokonezeka kwa mtima, kusokonezeka kwa kugunda kwa mtima).

Komanso, mankhwalawa amatha kuthana ndi ululu panthawi ya msambo komanso kukokana kwa nasopharyngeal.

Njira ndi mawonekedwe

Aspirin amalembedwa kwa akulu ndi ana omwe ali pamiyeso yotsatirayi:

• kuyambira zaka 6, theka la piritsi nthawi imodzi,
• kuyambira wazaka 12 ndi akulu theka kapena piritsi lonse.

Nthawi zambiri kumwa mankhwala 3-4 mawola 24, ndi imeneyi pafupifupi 4 maola. Mlingo woyenera wa tsiku lililonse kwa munthu wamkulu sayenera kupitirira magalamu atatu, ndiye kuti, mapiritsi 6, gawo limodzi lokha lovomerezeka ndi gramu imodzi. Kuti athetse matenda a mtima, amaloledwa kudya kuchokera ku 0,75 mpaka 3 magalamu tsiku lililonse.

Piritsi lililonse liyenera kutsukidwa ndi mkaka kapena madzi ambiri (amchere, osungunuka). Pankhaniyi, kugwiritsa ntchito ndalama kuyenera kuyikidwa pokhapokha chakudya.

Ngati mankhwalawa agwiritsidwa ntchito kuchepetsa kutentha, nthawi yogwiritsidwa ntchito popanda dokotala sayenera kupitilira masiku atatu. Ngati choyambitsa cha mankhwalawa chikupweteka kapena kutupa, mutha kuwonjezera nthawi mpaka sabata.

Njira zopewera kupewa ngozi

Kuti mukulitse luso la Acetylsalicylic Acid MS, ndikofunikira kutsatira njira zosavuta:

1. Musamayike aspirin musanakonzekere ntchito. Chidacho chikuwonjezera magazi, chifukwa ndiowopsa kugwiritsa ntchito musanachotse dzino. Ndi bwino kusiya asidi sabata imodzi musanachite opareshoni.
2. Chidacho chimathandizira mawonetsedwe a gouty.
3. Ndikofunika kumwa mapilitsi okha ndi madzi omwe akutsimikiziridwa, chifukwa amathandiza kuyamwa kwawo.
4. Simuyenera kuchita chilichonse pamimba yopanda kanthu, kuti musayambitse zilonda.

Pa nthawi yoyembekezera

Popeza acetylsalicylic acid MS ikhoza kulowa mu zotchinga, ndizoletsedwa kugwiritsa ntchito mankhwalawa nthawi iliyonse panthawi yapakati. The yogwira pophwanya zimakhudza mwana ndipo zimadzetsa kutsika, kufalikira kwa mitsempha ndi zotumphukira ziwiya, komanso kugawanika chapamwamba. Aspirin amabisala m'njira yoyamwitsa, yomwe imayambitsa magazi mwana wakhanda. Ngati amayi apezeka kuti ali ndi pakati pa mankhwalawa, mukuyenera kusiya kumwa mpaka kumapeto kwa yoyamwitsa.

Zotsatira zoyipa

Mosasamala kanthu za njira zopewera, zotsatira zotsatirazi zitha kuchitika chifukwa chogwiritsa ntchito acetylsalicylic acid MS:

• kusowa kwa chakudya, kupweteka m'mimba, kutentha pa chifuwa, chizungulire, nseru, kusanza,
• tinnitus, kupweteka pamutu, kunachepetsa kuwona ndi kumva,
• kuchuluka kwa mavuto a kayendetsedwe ka mtima ndi mitsempha ya magazi,
• kulakwitsa kwa impso kapena chiwindi, nephritis,
• kutupa kwa mmero ndi mphuno, kuyabwa ndi zotupa pakhungu.

Ngati mukupeza chimodzi mwazambiri mwazizindikirozi, muyenera kufunsa dokotala komanso kukonzedwa kuchipatala.

Bongo

Pazikhalidwe, mankhwala osokoneza bongo a aspirin agawika magawo atatu, iliyonse yomwe imakhala ndi ake ake amizere:

1. Yapakatikati. Kusungunula, kupweteka mutu, chizungulire, kuganiza kosamveka. Zimakhala zosavuta kuti wodwalayo achepetse kuchuluka kwa mankhwala omwe amwedwa.
2. Zovuta. Thupi, chikomokere, kuchepa kwambiri kwa kukakamiza, kumangidwa kwa kupuma kapena kuyesa kopanda mphamvu kukankhira mpweya m'mapapo, kuwonjezeka kwa kuchuluka kwa shuga ndi chakudya m'magazi, kuchuluka kwa asidi kungasokonezenso.
3. Matenda Zimatsimikiziridwa ndi kuchuluka kwa salicylic acid m'magazi. Ngati 0,7-1 g wa acetylsalicylic acid wapezeka pa kilogalamu ya kulemera, kuchipatala chofunikira kumachitidwa.

Nthawi zambiri, makala okhathamiritsa, hemodialysis, kulowetsedwa kwamadzimadzi, kuthetseratu zizindikiro zowoneka bwino kumagwiritsidwa ntchito pochiza. Mpweya wabwino wofunikanso ungafunikire.

Malo osungira

Acetylsalicylic acid MS iyenera kusungidwa pamalo abwino komanso owuma pomwe kutentha sikukwera pamwamba pa 25 digiri Celsius. Pankhaniyi, mapiritsi sayenera kuwonetsedwa ndi radiation ya ultraviolet, iyeneranso kubisika kwa ana. Alumali moyo wam'mapiritsiwo ndi miyezi 48, kuyambira tsiku lomwe lasonyezedwa pa phukusi. Sizoletsedwa kugwiritsa ntchito izi pambuyo pake.

Mwa mankhwala omwe ali ndi mawonekedwe ofanana ndipo amagwiritsidwa ntchito chimodzimodzi:

Komabe, malangizo a mankhwalawa safuna kuti munthu adzipatsenso mankhwala, koma afotokozereni za olondola molondola posankha analogue potengera mbiri yaudokotala.

Chilolezo cha Pharmacy LO-77-02-010329 cha June 18, 2019

Dzinalo Losayenerana

Acetylsalicylic acid (Acetylsalicylic acid).

Acetylsalicylic acid MS (medisorb) ndi mankhwala otchuka osagwiritsa ntchito mankhwala osokoneza bongo.

N02BA Salicylic acid ndi zotumphukira zake.

Pharmacokinetics

Mafuta amapezeka kuchokera m'matumbo athunthu. ASA imagawidwa mu minofu ngati anion ya salicylic acid. Mankhwalawa amangoikidwa mu madzi am'magazi, komanso m'mitsempha yamafupa a m'mafupa, komanso m'magazi amagetsi.

Mafuta amapezeka kuchokera m'matumbo athunthu.

Kuchokera mthupi, mankhwalawa amachotsedwa mu mawonekedwe a metabolites pogwiritsa ntchito kwamikodzo. Mlingo wa chotsekera - kuchokera 2 mpaka maola 30, kutengera mlingo.

Thandizo lanji

ASA ili ndi mawonekedwe osiyanasiyana, amachotsa zotupa ndikuchepetsa ululu. Kuphatikiza apo, mankhwala okhala ndi asidi ali ndi magazi omwe amachepetsa magazi, omwe amafunikira mankhwalawa komanso kupewa matenda amtima. Motere, mankhwalawa amagwiritsidwa ntchito pazotsatirazi:

• kuchuluka kwa kutentha kwa thupi munthawi yotupa ndi matenda opatsirana,
• kupewa magazi kuwundana ndi embolism, kupatsidwa zinthu za m'magazi, varicose mitsempha, thrombosis,
• kupweteka kwa chiyambi chilichonse: kusamba, mano, kupweteka mutu, zowawa, ndi zina zotere.
• pakuchita opaleshoni ndimagwiritsa ntchito jakisoni yothetsera kutentha thupi ndi zowawa,
• mtima pathologies: ischemia, arrhythmias, kupewa pafupipafupi myocardial infarction, stroke, matenda a Kawasaki, kugunda kwa mtima.

Mankhwalawa amagwiritsidwa ntchito ngati ischemia.
Mankhwalawa amagwiritsidwa ntchito ngati mitsempha ya varicose.
Mankhwalawa amagwiritsidwa ntchito kutentha kwambiri.

Piritsi imodzi imatha kutengedwa kuti muchepetse kutentha kapena kuchepetsa ululu wowonda. Mu pathologies aakulu, pofuna kupewa kapena kuchiza, acetylsalicylic acid amaledzera ndi zomwe adokotala amadziwitsa kutengera ndi matenda.

Momwe mungatenge acetylsalicylic acid MS

Mankhwala amatengedwa musanadye ndikutsukidwa ndi madzi ambiri oyera. Ndi kumwa kamodzi, 0,5 mg wa mankhwalawa (piritsi 1) limagwiritsidwa ntchito. Kugwiritsanso ntchito sikugwiritsidwe ntchito osapitirira maola 4. Mlingo wa tsiku ndi tsiku sayenera kupitilira mapiritsi 6.

Mankhwala osakanikirana a matenda owopsa kapena osachiritsika, ASA amapatsidwa mlingo wa 1 mg ya mankhwala (mapiritsi 2) katatu patsiku.

Kutalika kwa chithandizo sikupitilira masiku 7 ndi chithandizo chazonse komanso zosaposa 3 ndi kuchepa kwa kutentha. Mukamamwa mankhwalawa, ndikofunika kulabadira zakudya zopatsa thanzi.

Kuchokera kwamikodzo

Kukula kwa aimpso kulephera, kukodza pafupipafupi, nephrotic syndrome, kupezeka kwa kutupa kwakukulu nephritis.

Thupi lawo siligwirizana angayambe chifukwa cha tsankho kwa zigawo zikuluzikulu za kapangidwe ka mankhwala. Pathology imawonetsedwa ndi zotupa pakhungu, kuyabwa. Nthawi zina, pamakhala kupuma movutikira chifukwa cha kutupira kwa pharynx.

Kupatsa ana ntchito

Ana osaposa zaka 15 satalembedwe mapiritsi a ASA MS chifukwa chowopsa cha zotsatira zoyipa. Kupatula kunja kumachitika kutentha kwambiri, komwe dotolo amadzibaya "triad" (Aspirin, Analgin and No-Shpu) mu intramuscularly kuti vutoli lithe. Palibe zoopsa. Nthawi zonse, ASA ndi yoletsedwa ana.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Sindikulimbikitsidwa kumwa mankhwalawa panthawi yomwe muli ndi pakati, makamaka pa trimester yoyamba, mwana wosabadwayo akayamba kupanga. Mu trimester yachiwiri, mutha kugwiritsa ntchito mankhwalawa mulingo wocheperako, ngati zotsatira zomwe zikuyembekezeredwa zikupitilira chiwopsezo. Chifukwa mankhwalawa amalowerera kwathunthu m'magazi ndi maselo onse amthupi, pakubaka msanga kumakhala kowopsa kwambiri kuti asavulaze mwana.

The ntchito aimpso kuwonongeka

Pakulephera kwa impso, ASA sigwiritsidwa ntchito chifukwa cha kuthekera kochotsa zinthu zomaliza. Chifukwa cha izi, kagayidwe kachakudya kamasokonekera ndipo ntchito ya pafupifupi ziwalo zonse ndi machitidwe zimachepa.

Pakulephera kwa impso, ASA sigwiritsidwa ntchito chifukwa cha kuthekera kochotsa zinthu zomaliza.

Kuyenderana ndi mowa

Zakumwa zoledzeretsa zimakhala ndi ethanol, yomwe ikamayanjana ndi ASA imawonjezera chiopsezo chotaya magazi m'matumbo, kukula kwa gastritis kapena zilonda zam'mimba komanso chimbudzi.

Mwa mankhwala omwe amachitanso chimodzimodzi, zotsatirazi zitha kudziwika:

• Trombo Ass,
• Aspirin Cardio,
• Cardiomagnyl.

Mwa mankhwala omwe amachitanso chimodzimodzi, Cardiomagnyl titha kudziwika.
Mwa mankhwala omwe amachitanso chimodzimodzi, angathe kuzindikirika
Pakati pa mankhwala omwe adachitanso chimodzimodzi, Thrombo Ass.

Ndikofunika kukumbukira kuti chithandizo popanda kufunsa katswiri kungakhale koopsa ku thanzi, chifukwa chake muyenera kufunsa dokotala musanasinthe mankhwala.

Wopanga

CJSC Medisorb, Russia.

Marina Sergeevna, wazaka 48, Oryol

Ndakhala ndikutenga ASA kwa zaka zambiri kuti ndichepetse magazi. Cardiomagnyl adalembedwa kale, koma posaka ma analogi otsika mtengo, adokotala adalangiza kugwiritsa ntchito mankhwala a Medisorb. Mankhwala abwino kwambiri, ndimamwa mosamalitsa malinga ndi kuchuluka kwa mankhwalawo, panali zovuta zina.

Ivan Karlovich, wazaka 37, Yeysk

Kwa arthrosis yolumikizira, mapiritsi awa adalembedwa. Sindinganene kuti zonse zinasiya kupweteka, koma ululuwo unachepa kwakanthawi. ASA imathandiza kokha ndi zovuta mankhwala.