Irbesartan

Antihypertensive wothandizira, wapadera wosapikisana ndi angiotensin II receptor antagonist (mtundu wa AT1). Amachotsa vasoconstrictor zotsatira za angiotensin II ndikuchepetsa kuchuluka kwa aldosterone m'magazi am'magazi. Sizimaletsa kinase II - puloteni yomwe imawononga bradykinin. Amachepetsa OPSS, amachepetsa pambuyo pake, amachepetsa kuthamanga kwa magazi ndi kuthamanga kwa magazi mu magazi. Kuchuluka kwake kumachitika pambuyo pa maola 3-6 pambuyo pa limodzi. Mphamvu ya antihypertensive imapitirira kwa maola 24. Khola lolimba lachipatala limatheka pambuyo pa masabata 1-2 atatha kugwiritsa ntchito irbesartan. Pambuyo poletsa kudya kwa magazi pang'onopang'ono kumabwerera pamlingo wake woyambirira. Irbesartan sichikhudza kuchuluka kwa TG, kuchuluka kwa cholesterol, glucose, uric acid m'madzi am'magazi kapena zotupa za uric acid mkodzo.
Pambuyo pakukonzekera pakamwa, imatengedwa bwino kwambiri kuchokera m'mimba. Pazipita ndende ya irbesartan m'madzi am'magazi amafikira pambuyo pa maola 1.5-2 atalowa mkati. Bioavailability ndi 60-80%. Kudya panthawi imodzi sikukhudza bioavailability. Kumanga mapuloteni kuli pafupifupi 90%. Irbesartan imapangidwa mu chiwindi chifukwa cha kuphatikizika kwa kupanga glucuronide komanso chifukwa cha oxidation. Metabolite yayikulu ndi irbesartan glucuronide (pafupifupi 6%). Kutha kwa theka-moyo ndi maola 11-15. Odwala omwe ali ndi vuto la chiwindi ndi / kapena impso, ma paracokinetic magawo a irbesartan sanasinthe kwambiri.

Kugwiritsa ntchito mankhwala Irbesartan

Mlingo woyambirira ndi 150 mg kamodzi patsiku, ndiye kuti mlingowo ungathe kuwonjezeka mpaka 300 mg kamodzi patsiku, kumwa ndi chakudya kapena pamimba yopanda kanthu. Ndikulimbikitsidwa kutenga tsiku lililonse pafupifupi nthawi yomweyo. Mukaphonya mlingo, mlingo wotsatira watsiku ndi tsiku suyenera kuwonjezeredwa. Kuphatikiza mankhwala ndi irbesartan osakanikirana ndi okodzetsa (hydrochlorothiazide) kapena mankhwala ena a antihypertensive ndikotheka.

Malangizo apadera ogwiritsira ntchito mankhwala a Irbesartan

Mlingo wambiri wokodzetsa asanafike irbesartan kungayambitse kuchepa kwamadzi ndipo kumawonjezera chiopsezo cha hypotension kumayambiriro kwa chithandizo. Ndi kuchepa mphamvu kwambiri kwa madzi m'thupi kapena hyponatremia chifukwa cha kukodzetsa kwambiri kwa thupi, kudya kwa hyponatrium, kutsegula m'mimba kapena kusanza, komanso kwa odwala hemodialysis, mlingo wa irbesartan uyenera kuchepetsedwa.
Ngati ndi kotheka, kuikidwa kwa irbesartan pa nthawi yoyamwitsa kuyenera kuganizira za kutha kuyamwitsa. Chitetezo ndikuyenera kwa irbesartan mwa ana sichinakhazikitsidwe.

Pharmacology

Makulidwe kwambiri komanso osasinthika otsekera angiotensin II receptors (AT subtype₁) Amathetsa vasoconstrictor mphamvu ya angiotensin II, amachepetsa kuchuluka kwa aldosterone mu plasma, amachepetsa OPSS, pambuyo pake pa mtima, zokhudza zonse magazi ndi kuthamanga kwa kufalikira. Zisakhudze kinase II (ACE), yomwe imawononga bradykinin ndipo ikuphatikizidwa ndikupanga angiotensin II. Imagwira pang'onopang'ono, pakatha kamodzi kamodzin'kamodzi, mphamvu yake imayamba pambuyo pa maola 3-6. Mphamvu ya antihypertgency imapitilira maola 24. Mukagwiritsidwa ntchito pafupipafupi kwa masabata 1-2, zotsatira zake zimakhala zokhazikika ndikufikira patatha masabata 4-6.

Mofulumira komanso odziwitsidwa kwathunthu kuchokera kumimba yokumba, kuchuluka kwa mayamwidwe kumayima pawokha pakudya. Bioavailability - 60-80%, C_max anatsimikiza pambuyo 1.5-2 maola. Pali ubale wautali pakati pa mlingo wa irbesartan ndi ndende yake m'magazi (muyezo wa 10-600 mg). Kufanana kwa plasma ndewu kumafikiridwa patatha masiku atatu mutangoyamba chithandizo. Madzi a protein a plasma ndi 96%, voliyumu yogawa ndi 53-93 L, Cl yonse ndi 157-66 ml / mphindi, aimpso ndi 3-3,5 ml / mphindi. Imadutsa biotransformation mu chiwindi ndi makutidwe ndi okosijeni ndi gawo la isoenzyme CYP2C 9 la cytochrome P450 ndi kulumikizana kwotsatira ndi mapangidwe a metabolites osagwira, omwe kwakukulu ndi irbesartan glucuronide (6%). T_1/2 - Maola 11 mpaka 15. Atakulimbikitsidwa ndi impso (20%, pomwe osachepera 2% osasinthika) ndi chiwindi.

Kuwongolera nyama (makoswe, macaques) muyezo waukulu (woposa 500 mg / kg / tsiku) kumayendera limodzi ndi kusintha kwa impso (interstitial nephritis, kukula kwa tubular ndi / kapena basophilic kulowetsedwa kwa impso tubules, kuchuluka kwa uric acid ndi creatinine mu plasma) ndi kuchepa aimpso mafuta. Pa Mlingo wopitilira 90 mg / kg / tsiku (makoswe) ndi 110 mg / kg / tsiku (macaques) amatenga hypertrophy / hyperplasia ya maselo a juxtaglomerular.

Mu nthawi yayitali (2 years) yoyang'anira nyama zoyesera pa MPD, katatu, makoswe amphongo), nthawi 3-5 (mbewa zazimuna ndi zazikazi) ndi nthawi 21 (makoswe amphongo) sizinapezeke. Pophunzira mitundu ina ya kawopsedwe, mutagenic ndi teratogenic ntchito sizinapezeke.

Zotsatira zoyipa za zinthu Irbesartan

Kuchokera wamanjenje ndi ziwalo zam'maganizo: ≥1% - mutu, chizungulire, kutopa, nkhawa / kusangalala.

Kuchokera pamtima ndi magazi (hematopoiesis, hemostasis): ≥1% - tachycardia.

Kuchokera pakapumidwe: ≥1% - matenda amtundu wa kupuma kwamatumbo (malungo, zina), sinusopathy, sinusitis, pharyngitis, rhinitis, chifuwa.

Kuchokera mmimba: ≥1% - matenda otsekula m'mimba, nseru, kusanza, zizindikiro za kukomoka, kutentha kwa mtima.

Kuchokera ku minculoskeletal system: ≥1% - kupweteka kwa minofu ndi mafupa (kuphatikizapo myalgia, kupweteka m'mafupa, pachifuwa).

Zotsatira zoyipa: ≥1% - zotupa.

Zina: ≥1% - kupweteka pamimba, matenda amkodzo.

Kuchita

Ma diuretics ndi mankhwala ena a antihypertensive. Thiazide okodzetsa amalimbikitsa zotsatira. Pamaso mankhwala asanafike diuretics mu Mlingo wambiri kumatha kubweretsa vuto lakumadzi ndipo kumawonjezera chiopsezo cha ochepa hypotension kumayambiriro kwa mankhwala ndi irbesartan. Irbesartan imagwirizana ndi mankhwala ena a antihypertensive (beta-blockers, calcium block blockers).

Potaziyamu zowonjezera ndi potaziyamu wolekerera okodzetsa. Amawonjezera chiopsezo cha hyperkalemia akagwiritsidwa ntchito limodzi ndi potaziyamu-pofinya okodzetsa ndi potaziyamu.

Lithium: kuchuluka kosintha kwa seramu lifiyumu kapena poizoni kunawonedwa pogwiritsa ntchito munthawi yomweyo kugwiritsa ntchito lifiyamu ndi angiotensin potembenuza enzyme. Ponena ndi irbesartan, zotsatira zofananira sizinakhalepo kwambiri mpaka pano, koma kuwunikira mosamala kuchuluka kwa seramu lifiyamu kumalimbikitsidwa panthawi yomwe mukugwiritsa ntchito mankhwala.

NSAIDs: ndi makonzedwe omwewo a angiotensin II okonda ndi NSAIDs (mwachitsanzo, kusankha COX-2 zoletsa, acetylsalicylic acid> 3 g / tsiku ndi NSAIDs zosasankha), zotsatira zowononga zitha kufooka.

Monga ACE zoletsa, kuphatikiza kwa angiotensin II antagonists ndi NSAIDs kungakulitse chiopsezo cha vuto laimpso, kuphatikizapo mwayi wa kulephera kwaimpso, ndikuwonjezera kuchuluka kwa serum potaziyamu, makamaka kwa odwala omwe ali ndi vuto la impso. Mwa kuyambitsa kuphatikiza kumeneku, kusamala kuyenera kuchitika. Odwala amafunika kuchita ma hydrate oyenerera ndikuwunika ntchito yaimpso nthawi yonse yomwe amaphatikiza ndipo nthawi zina itatha.

Hydrochlorothiazide. Ma pharmacokinetics a irbesartan sasintha akaphatikizidwa ndi hydrochlorothiazide.

Irbesartan imapangidwa makamaka ndi kutenga CYP2C9 ndipo, pochepera, glucuronidation. Palibe zofunika zamankhwala kapena mankhwala a pharmacodynamic omwe adawonedwa ndi kuphatikiza kwa irbesartan ndi warfarin, mankhwala omwe amapangidwa ndi CYP2C9. Zotsatira za CYP2C9 zolimbikitsa monga rifampicin pa pharmacokinetics za irbesartan sizinayesedwe.

Irbesartan sasintha pharmacokinetics a digoxin.

Mosamala Irbesartan

Amagwiritsidwa ntchito mosamala odwala omwe ali ndi hyponatremia (mankhwala othandizira okodzetsa, kutsekeka kwa mchere wambiri ndi zakudya, kutsegula m'mimba, kusanza), mwa odwala hemodialysis (kukulitsa kwa hypotension ya dalili ndikotheka), komanso kwa odwala omwe alibe madzi m'thupi. Chenjezo liyenera kuchitika kwa odwala omwe akukonzanso matenda oopsa chifukwa cha mtima wamitsempha. Matenda a impso imodzi (chiwopsezo chachikulu cha kufooka kwa magazi komanso kulephera kwa aimpso), aortic kapena mitral stenosis, hypertrophic cardiomyopathy, kugunda kwamtima kwambiri (gawo III - IV NYHA) ndi matenda a mtima (chiwopsezo chowonjezereka cha myocardial infarction, angina pectoris). Malinga ndi maziko aimpso kuwonongeka, kuyanʻanila serum potaziyamu ndi creatinine wambiri akulimbikitsidwa. Sizikulimbikitsidwa kwa odwala omwe ali ndi vuto lalikulu la hyperaldosteronism, omwe ali ndi vuto lalikulu la impso (palibe chokumana nacho chachipatala), mwa odwala omwe akuwonjezeka impso (osadziwa zamankhwala).

Kutulutsa mawonekedwe ndi kapangidwe kake

Mtundu wa Irbesartan ndi mapiritsi okhala ndi mafilimu: biconvex, kuzungulira, chigoba ndi pakati ndizoyera kapena zoyera (m'matumba a 3, 4, 7, 10, 14, 15, 20, 25, 30 kapena 30 ma PC.). 1-8 kapena 10 mapaketi aikidwa, mumakani a polyethylene terephthalate 10, 14, 20, 28, 30, 40, 50, 60, 100 kapena 100 ma PC.

Piritsi limodzi lili ndi:

• yogwira mankhwala: irbesartan - 75, 150 kapena 300 mg,
• zina zowonjezera (75/150/300 mg): cellcrystalline cellulose - 24/48/96 mg, lactose monohydrate (mkaka wa shuga) - 46.6 / 93.2 / 186.4 mg, colloidal silicon dioxide - 0,8 / 1 , 6 / 3.2 mg, croscarmellose sodium - 7.2 / 14.4 / 28.8 mg, magnesium stearate - 1.6 / 3.2 / 6.4 mg, povidone-K25 - 4.8 / 9, 6 / 19.2 mg
• chipolopolo (75/150/300 mg): titanium dioxide - 1.2 / 2.4 / 4.8 mg, macrogol-4000 - 0.6 / 1.2 / 2.4 mg, hypromellose - 2.2 / 4 4 / 8.8 mg.

Mankhwala

Irbesartan, pokhala wosankha wotsutsana ndi angiotensin II receptors (mtundu wa AT1), amathandizira kuthetsa vasoconstrictor mphamvu ya angiotensin II, kutsitsa plasma ndende ya aldosterone m'magazi (popanda kupondereza kinase II, yomwe imawononga bradykinin, imachepetsa kupindika kwamitsempha yamagazi kukana, ndikuchepetsa kuthamanga kwa magazi (AD) , kutsitsa komanso kukakamiza kufalitsidwa. Zilibe kukhudza plasma ndende ya cholesterol, triglycerides, shuga, uric acid ndi kuchuluka kwa uric acid.

Kutsika kwakukulu kwa kuthamanga kwa magazi kumachitika pambuyo pa maola 3-6 pambuyo pakukonzekera kwa pakamwa, mankhwala a antihypertgency amasungidwa kwa maola osachepera a 24. Patatha tsiku limodzi makonzedwe, kuchepa kwa kuthamanga kwa magazi ndi 60-70% poyerekeza ndi kuchepa kwakukulu kwa kuthamanga kwa diastoli / systolic poyankha kumwa mankhwalawa. Mukamamwa 150-300 mg 1 nthawi imodzi patsiku, kuchuluka kwa kuchepa kwa magazi kumapeto kwa gawo la interdose (mwachitsanzo, maola 24 mutatha kumwa mankhwalawo) wodwalayo atakhala kapena malo ogona amakhala pafupifupi 5-8 / 8-13 mm Hg. Art. (motsatana) kuposa placebo. Kuyankha kwa antihypertensive kumwa mankhwalawa kwa mlingo wa 150 mg 1 nthawi patsiku sikusiyana ndi kugwiritsa ntchito mankhwalawa 2 waukulu. Mphamvu ya antihypertensive ya irbesartan imayamba mkati mwa masabata awiri, ndipo pazotheka kwambiri achire zimatheka pambuyo pa masabata 4-6 kuyambira poyambira chithandizo. Pambuyo pakuimitsa mankhwalawa, kuthamanga kwa magazi kumabwereranso ku phindu lake loyambirira, popanda chitukuko cha matenda obwera nawo. Kuti mukwaniritse khola la antihypertensive kwenikweni, chithandizo chambiri ndichofunika.

Kuchita bwino kwa irbesartan sikukutengera jenda komanso zaka.

Odwala a mpikisano wa Negroid samvera kwenikweni monotherapy ndi mankhwalawa.

Pharmacokinetics

Mayamwidwe: Irbesartan pambuyo m`kamwa makonzedwe bwino odzipereka kwa m'mimba thirakiti. Kuchuluka kwa plasma ndende m'magazi kumachitika pambuyo 1.5-2 mawola kukonzekera pakamwa, mtheradi bioavailability chizindikiro ndi 60-80%. Kudya sikumakhudza kwambiri bioavailability. Irbesartan ali ndi kuchuluka kwa mankhwalawo komanso ma linear a pharmacokinetics pamiyeso yambiri ya 10-600 mg, pamadontho apamwamba (2 mochulukira kuposa pazofunikira kwambiri), kinetics ya chinthu imakhala yosagwirizana.

Kugawa: kumangika kwa chinthu kuma protein a plasma kuli pafupifupi 96%. Kulumikizana ndi ma cell a magazi ndi kochepa. Kuchuluka kwa magawano ndi malita 53-93. Mgwirizano wofanana ndi kudya kwa 1 kwa tsiku tsiku lililonse kumafikira pakatha masiku atatu. Ndi Mlingo wobwereza, palinso kuchuluka kwazinthu za m'madzi a m'magazi (mfundo 9 pamiyeso ya Mwana-Pugh),

Achibale (matenda / mikhalidwe yomwe makonzedwe a Irbesartan amafunikira kusamaliridwa):

• hypertrophic obstriers cardiomyopathy,
• mitral / aortic vala stenosis,
• hyponatremia,
• Hypovolemia,
• kutsatira zakudya zokhala ndi mchere wochepa,
• kusanza, kusanza,
• bilteryal aimpso mtsempha wamagazi,
• unenatal stenosis ya mtsempha wama impso umodzi,
• matenda a mtima ndi / kapena zotupa za mitsempha yaubongo,
• Kulephera kwamtima kwa mtima kwa III - kalasi yogwira ntchito malinga ndi gulu la NYHA,
• kulephera kwa aimpso
• Hyperkalemia
• pambuyo kupatsirana kwa impso,
• hemodialysis
• chachikulu hyperaldosteronism,
• kuphatikiza mankhwala ndi okodzetsa,
• kuphatikiza pamodzi ndi mankhwala omwe si a antiidal anti-yotupa, kuphatikizapo cycloo oxygenase II inhibitors, angiotensin-akatembenuza enzyme inhibitors kapena aliskiren,
• zaka zopitilira 75.

Malangizo ogwiritsira ntchito Irbesartan: njira ndi mlingo

Irbesartan amatengedwa pakamwa, akumeza miyala yonse ndi kumwa madzi. Mutha kugwiritsa ntchito mankhwalawa mosasamala nthawi yakudya.

Mlingo woyambira / wokonza ndi 150 mg kamodzi patsiku (umapereka kuyendetsa bwino kwa magazi masana, nthawi zina, makamaka odwala hemodialysis, kapena odwala omwe ali ndi zaka zopitilira 75, mlingo woyamba ndi 75 mg). Ngati achire sangathe, mlingowo ungathe kuwonjezeka ndi 2 times.

Pankhani ya kuchepa kwakwanira kwa kuthamanga kwa magazi monga monotherapy, okodzetsa kapena ena othandizira antihypertensive atha kuwonjezeredwa ku Irbesartan.

Ndi ochepa matenda oopsa ndi mtundu 2 shuga mellitus, mankhwalawa ayenera kuyamba ndi 150 mg kamodzi patsiku ndipo pang'onopang'ono ukuwonjezeka mpaka 300 mg - mlingo womwe ungakhale wofunika kwambiri pa matenda a nephropathy.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi kuphatikiza kwa Irbesartan ndi mankhwala / zinthu zina, zotsatirazi zingakhale:

• Mankhwala okhala ndi aliskiren: kuphatikiza kumapangidwira odwala omwe ali ndi matenda osokoneza bongo kapena kulephera kwapakati / koopsa kwa odwala, osavomerezeka.
• angiotensin akatembenuka enzyme zoletsa: kuphatikiza ali contraindicated odwala ndi matenda ashuga nephropathy, odwala ena ali osavomerezeka,
• okodzetsa (asanafike mankhwalawa muyezo waukulu): kuchepa madzi m'thupi ndi kuwonjezeka kwa vuto linzake kumayambiriro kwa ntchito kwa Irbesartan,
• okodzetsa ndi othandizira ena othandizira: kukweza antihypertensive kwambiri (mwina kuphatikiza chithandizo ndi β-adrenergic blockers, ogwira ntchito pang'onopang'ono calcium calcium blockers ndi thiazide diuretics),
• Kukonzekera kwa lithiamu: kuwonjezereka kosinthika kwa kuchuluka kwa seramu lifiyamu m'magazi kapena kuwopsa kwake (ngati kuli koyenera, kugwiritsa ntchito palimodzi kumafunikira kuwunika mosamala ma lithium ndende),
• Kukonzekera kwa potaziyamu, mayankho amadzimadzi a electrolyte okhala ndi potaziyamu, mankhwala ochepetsa potaziyamu, mankhwala omwe angapangitse kuchuluka kwa potaziyamu m'magazi, kuphatikiza heparin: kuchuluka kwa seramu potaziyamu m'magazi,
• nonsteroidal anti-yotupa mankhwala: kufooketsa mphamvu ya antihypertensive ya irbesartan, kukulitsa mwayi wokhala ndi vuto la impso, kuphatikizapo chiopsezo cha kulephera kwaimpso, komanso kuwonjezeka kwa serum potaziyamu, makamaka ndi kuwonongeka kwa impso kale , muyenera kubwezeretsanso kuchuluka kwa magazi nthawi yonse yophatikiza mankhwala, komanso pambuyo pake Kuthetsa, kuwunika ntchito aimpso).

Ma Analogs a Irbesartan ndi awa: Aprovel, Firmasta, Ibertan, Irsar, ndi ena.

Ndemanga pa Irbesartan

Malinga ndi ndemanga, Irbesartan ndi imodzi mwamankhwala omwe amapezeka pochiza matenda othamanga / othamanga. Kuchita kwake kwambiri pamagazi oopsa (ndi tsiku lililonse la 300 mg) komanso kuwonjezeka kwa kuthamanga kwa magazi usiku kumasonyezedwanso. Mankhwala, monga lamulo, amalola bwino ndipo amatsogolera pakukula kwa zoyipa (makamaka mwa kufooka ndi chizungulire) pokhapokha pena.

Palinso ndemanga pazakuchita kwa Irbesartan polimbana ndi matenda ashuga komanso matenda a shuga.

Contraindication

• wazaka 18
• Hypersensitivity
• mimba,
• yoyamwitsa.

Ndi mosamala amayika liti aortic valve stenosis, CHF, kusowa kwamadzi, kutsegula m'mimbakusanza hyponatremia, stenosismtsempha wamagazi (unilateral ndi mayiko awiri).

Irbesartan, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Mapiritsi amatengedwa pamimba yopanda kanthu kapena ndi chakudya, kumezedwa kwathunthu. Yambani chithandizo ndi 150 mg patsiku. Mlingowu umapereka chiwongolero chokwanira masana poyerekeza ndi 75 mg / tsiku.

Pambuyo pake, amakula mpaka 300 mg patsiku, koma osatinso, popeza kuwonjezeraku sikumawonjezera chiwopsezo cha hypotensive. Poterepa, tikulimbikitsidwa kuti tiwonjezere diuretics. Odwala achikulire osaposa zaka 75, omwe alipo hemodialysis ndi kusowa kwamadzi Yambani chithandizo ndi 75 mg, monga chisonyezo ochepa hypotension. Odwala kulephera kwa aimpso ayenera kuyang'anira ndende creatinine ndi potaziyamu m'magazi. Zowopsa CH chiwopsezo chowonjezereka azotemia ndi oliguriaat mimosokoma - chiwopsezo myocardial infaration. Popeza kuti chithandizo ndichotheka chizungulire ndi kutopa, samalani mukamayendetsa.

Bongo

Zimadziwulula yokha tachycardia kapena bradycardiakuchepa kuthamanga kwa magazi, kugwa. Kuchiza kumayamba ndi kupweteka kwam'mimba ndi kutsata. kaboni yodziyambitsa. Otsatirawa ndi chizindikiro cha mankhwala.

Kupanga ndi mawonekedwe a kumasulidwa

Mankhwalawa amagulitsidwa mwanjira ya mapiritsi okhala ndi ntchito. Chofunikira chachikulu cha mankhwalawa ndi irbesartan yokha. Mankhwalawa ndi a antihypertensive mankhwala. Irbesartan ndiyotsika mtengo. M'masitolo ogulitsa, malinga ndi omwe amapereka, zitha kugulidwa pa 260-300 p. (Mapiritsi 28).

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Analogs of Irbesartan, malangizo ogwiritsa ntchito omwe akambirana pansipa, angafotokozedwe m'malo mwa mankhwalawa chifukwa chotsutsana ndi wodwala pazinthu zake kapena kuthekera kwa kutengedwa chifukwa chakusowa kwa mankhwala. Komanso m'nkhaniyi tikambirana za m'malo mwa chida ichi. Tsopano timvetsetsa chomwe mankhwalawo pawokha ndi, komanso momwe angamwere bwino.

Mankhwalawa amathandizira makamaka matenda oopsa. Nthawi zina amalembera sekondale. Komanso, mankhwalawa amathanso kukhudza thupi la odwala omwe ali ndi matenda monga nephropathy okhala ndi matenda ashuga 2 komanso matenda oopsa. Komabe, pankhaniyi, mankhwalawa "Irbesartan" amagwiritsidwa ntchito limodzi ndi mankhwala ena.

Palibe zotsutsana zilizonse za mankhwalawa. Simungathe kuzitenga kokha kwa anthu omwe sakhudzidwa ndi chilichonse chomwe chimapanga. Komanso, kugwiritsa ntchito mankhwalawa sikuloledwa kwa amayi apakati komanso oyamwitsa, ana ochepera zaka 18. Nthawi zina, mankhwalawa amayenera kumwedwa mosamala. Poyang'aniridwa ndi achipatala, iwo amamwa, mwachitsanzo, matenda monga hyponatremia ndi kufooka kwa madzi m'thupi.

Zotsatira zoyipa zingakhale ndi

Kugwiritsa ntchito "Irbesartan" kumatheka pokhapokha ngati dokotala wakuwuzani. Mankhwala, chida ichi chimagulitsidwa ndi mankhwala. Zotsatira zoyipa Irbesartan imatha kupereka zosiyanasiyana. Mwachitsanzo, wodwala amatha kukumana ndi mavuto otsatirawa:

mutu kapena chizungulire,

matenda kupuma, rhinitis ndi malungo,

kutsegula m'mimba, kutentha kwa mtima, nseru komanso kusanza,

Nthawi zina mankhwalawa amaperekanso chosasangalatsa monga matenda a kwamkodzo kapena kupweteka kwam'mimba.

Kodi mankhwalawa amagwira ntchito bwanji?

Mankhwala Irbesartan kuchokera m'matumbo am'mimba amatengedwa mwachangu komanso bwino. Ngati yogwira pophika imafikira m'madzi a m'magazi pambuyo pa 1.5-2 mawola. Mthupi la wodwalayo, mankhwalawa amatchinga ma receptors a AT1, amachepetsa zovuta za agiotensin II, amathandizira kutulutsidwa kwa aldosterone ndikuyambitsa dongosolo lamanjenje lamumvera. Chifukwa cha zonsezi, wodwalayo amachepetsa kuthamanga kwa magazi.

Mankhwalawa amachotsedwa m'thupi la wodwalayo ndi mkodzo ndi ndulu.

Zofananira zabwino za Irbesartan

Ngati pali zotsutsana chifukwa chomwa mapiritsiwa kapena pazifukwa zina, dokotalayo amatha kupereka mankhwala m'malo mwa wodwalayo. Nthawi zambiri, mankhwala omwe ali ndi vuto lofanana ndi achire, monga Aprovel, Valzan, Losartal, kapena Irsar, amagwiritsidwa ntchito pochiza.

Zofanizira zonsezi za Ibersartan adalandiranso ndemanga zabwino kuchokera kwa odwala ndi madokotala.

Mankhwala aprovel: mawonekedwe a kumasulidwa ndi mawonekedwe

Chofunikira chachikulu pa mankhwalawa ndi irbesartan. Ndiye kuti, amatanthauza zofananira za njira zomwe tafotokozera. Zizindikiro zogwiritsa ntchito mankhwalawa ndizofanana ndi Irbesartan. Gwiritsani ntchito makamaka kwa matenda oopsa komanso nephropathy limodzi ndi othandizira ena. Zotsatira zake zoyipa ndizofanana ndi za Irbesartan. Mankhwalawa amadziwikiridwa mu mapiritsi omwewo.

Ambiri ofanana ndi ndemanga za odwala a Irbesartan amayenera kuchita bwino. Koma lingaliro labwino pakati pa odwala ndi madokotala linali lokhudza cholowa cha Aprovel. Mankhwalawa ndiokwera mtengo kuposa Irbesartan. Mapiritsi 28 a chida ichi azilipira 550-650 p. Komabe, mankhwalawa amapangidwa ndi kampani yotchuka ya ku France Sanofi-Winthrop. Ndiye kuti, ndi cholocha cha mtundu wa Irbesartan.

Mankhwala "Irsar"

Madotolo amapereka mankhwala awa chifukwa chofunikira kwa matenda oopsa nthawi zambiri. Zomwe zimagwiritsidwa ntchito momwemo ndi irbesartan. Mankhwalawa amagulitsidwa mwanjira ya mapiritsi wamba pangozi. Zizindikiro, contraindication ndi malangizo ogwiritsira ntchito ndi iye sizosiyana ndi Irbesartan. Mankhwalawa ndi ofunika pafupifupi 350-450 p. mapiritsi 28. Koma nthawi zina m'mafakitala amaperekedwanso kwa 600-650 r.

Mankhwala "Valzan"

Ma analogi a Irbesartan omwe amafotokozedwa pamwambapa amaperekedwa potengera zomwe zimapangidwira chimodzimodzi. Koma mankhwalawa ali ndi choloweza mmalo china. Zida zazikulu zomwe zimagwiritsidwa ntchito mu mankhwala "Valzan", mwachitsanzo, ndi hydrochlorothiazite ndi valsartan. Mankhwalawa amaperekedwa kumsika momwe amapangira mapiritsi a matuza. M'malo mwa Irbesartan, itha kutumizidwa chifukwa cha matenda oopsa. Zowonetsa kuti mankhwalawa akugwiritsidwa ntchito ndi aposachedwa mtima.

Simungatenge "Valzan" wamatenda owopsa a chiwindi, pakati, poyamwitsa. Komanso, mankhwalawa samaperekedwa kwa ana osakwana zaka 18. Zotsatira zoyipa za mankhwalawa zimatha kupereka pafupifupi Irbesartan. Mankhwala "Valzan" ndi otsika mtengo. Mapiritsi 30 a mankhwala awa mu mankhwala azachipatala muyenera kulipira pafupifupi 15-20 p.

Mlingo woyambirira wa mankhwalawa ndi 80 mg kamodzi patsiku. M'milungu iwiri yotsatira, nthawi zambiri zimachuluka kufika pa 160 mg patsiku. Muzochitika zazikulu kwambiri, wodwalayo amatha kutenga mpaka 34 mg tsiku lililonse.

Mankhwala "Losartan"

Zofanizira zina za Irbesartan ku Russia zitha kugulidwa zotsika mtengo. Izi sizikukhudzana ndi mankhwala a Valzan okha, komanso mwachitsanzo, mankhwala a Lozartan. Ndiwothandiza kwambiri m'malo mwa Irbesartan. Chofunikira chachikulu pa mankhwalawa ndi losartan potaziyamu. Mankhwala amapangidwa mapiritsi okhala ndi ntchito. "Losartan" imatha kutumizidwa kwa odwala omwe ali ndi matenda oopsa, kulephera kwa mtima, komanso nthawi zina.

Mankhwalawa ali ndi zotsutsana zingapo kuposa mankhwala omwe tafotokozawa. Kuphatikiza pa kutenga pakati komanso kubereka, mankhwalawa sayenera kuledzera, mwachitsanzo, ndi madzi am'mimba, kulephera kwambiri kwaimpso, nthawi yomweyo monga Aliskiren. Mankhwalawa amalipira ma ruble 60-100 pamsika phukusi la mapiritsi 30.

Malingaliro a odwala zokhudzana ndi mankhwala "Irbesartan"

Chifukwa chake, tidazindikira zomwe kukonzekera kwa Irbesartan kumayimira (malangizo ogwiritsira ntchito, analogues). Ndemanga za mankhwalawa zili zabwino zokhazokha. Kupanikizika kumachepetsa bwino mankhwalawo. Komabe, kutenga izi kuti zithetse bwino, malinga ndi odwala ambiri, kuyenera kukhala nthawi yayitali.

Mlingo

Mapiritsi okhala ndi mafilimu 75 mg, 150 mg kapena 300 mg

Piritsi limodzi lili

ntchito yogwira irbesartan - 75 mg kapena 150 mg, kapena 300 mg

muwothandiziraszinthukoma: microcrystalline cellulose PH 101, calcium carmellose, povidone K-30, silicon dioxide colloidal anhydrous, calcium stearate, madzi oyeretsedwa

kapangidwe ka chipolopolo: Opadry yoyera OY-S-38956, madzi oyeretsedwa

zikuchokera opadry yoyera OY-S-38956: hypromellose, titanium dioxide E171, talc.

Mapiritsi okhala ndi mawonekedwe a Capsule, okhala ndi biconvex kumtunda, atakulungidwa ndi utoto wazithunzi zoyera kapena pafupifupi zoyera ndi zolemba "158" mbali imodzi ndi "H" mbali inayo (kwa mulingo wa 75 mg).

Mapiritsi okhala ndi mawonekedwe a Capsule, okhala ndi biconvex pamtunda, atakulungidwa ndi utoto wazithunzi zoyera kapena pafupifupi zoyera ndi zolemba "159" mbali imodzi ndi "H" mbali inayo (kwa mulingo wa 150 mg).

Mapiritsi okhala ndi mawonekedwe a Capsule, okhala ndi biconvex kumtunda, atakulungidwa ndi utoto wazithunzi zoyera kapena pafupifupi zoyera ndi zolemba "160" mbali imodzi ndi "H" mbali inayo (kwa mulingo wa 300 mg).

Fgulu laacacotherapeutic

Mankhwala osokoneza bongo omwe amakhudza dongosolo la renin-angiotensin. Angiotensin II okana. Irbesartan

ATX Code C09CA04