Mankhwala Astrozone: malangizo ntchito

Mankhwala amapezeka monga mapiritsi. Chofunikira chachikulu ndi pioglitazone mu Mlingo wa 30 mg. Zowonjezera zomwe zimapanga: lactose, magnesium stearate, hyprolose, croscarmellose sodium.

Mapiritsi amayikidwa mu zotumphukira m'matumba 10 zidutswa.

Mu phukusi 1 la makatoni mukhonza kukhala atatu kapena 6 mwa phukusi ili. Komanso, mankhwalawa amatha kupezeka mumatumba a polymer (mapiritsi 30 aliyense) ndi mabotolo omwewo (zidutswa 30).

Zotsatira za pharmacological

Clinical microbiology imagawa mankhwalawa ngati mankhwala a thiazolidinedione. Mankhwalawa ndi wosankha wokonda eni ake a ma gamma zolandilira payekha.

Mu matenda a shuga a mtundu wachiwiri, mankhwalawa amachepetsa kukanira kwa insulin.

Amatha kupezeka m'chiwindi, minofu ndi adipose minofu. Chifukwa cha kuthandizira kwa ma receptor, kusintha kwa majini komwe kumapangitsa chidwi cha insulin kumasinthidwa mwachangu. Amathandizanso poteteza matenda a shuga m'magazi.

Ma metabolic a metabolid a metabolid abwereranso kwatsopano.

Mlingo wa kukana kwa zotumphukira zimakhala kuchepa, zomwe zimapangitsa kuti shuga ayambe kudalira insulin. Poterepa, mulingo wa hemoglobin mu seramu yamagazi umakhala wofanana.

Mu matenda a shuga a mtundu wachiwiri, insulin kukana maselo a chiwindi amachepetsa kwambiri. Izi zimabweretsa kuchepa kwa kuchuluka kwa shuga m'magazi, kuchuluka kwa insulin m'madzi am'magazi kumatsikanso.

Pharmacokinetics

Mutatha kumwa mapiritsi pamimba yopanda kanthu, kuchuluka kwa pioglitazone m'madzi a m'magazi kumachitika pakatha theka la ola. Ngati mumwa mapiritsi mutatha kudya, ndiye kuti mavutowo amakwaniritsidwa maora angapo. Bioavailability komanso womanga kumapuloteni amwazi ndiwambiri.

Kagayidwe ka pioglitazone kamapezeka m'chiwindi. Hafu ya moyo ndi pafupifupi maola 7. Zinthu zogwira ntchito zimapukusidwa mu mawonekedwe a metabolites ofunikira limodzi ndi mkodzo, bile ndi ndowe.

Zinthu zogwira ntchito za Astrozone zimapukusidwa mu mawonekedwe a metabolites ofunikira ndi mkodzo.

Contraindication

Milandu yonse yokhudza kugwiritsa ntchito mankhwalawa ndi:

kuchuluka kwa zigawo zikuluzikulu,
mtundu 1 shuga
matenda ashuga ketoacidosis,
zovuta mu chiwindi ndi impso,
Mimba ndi kuyamwa
ana ochepera zaka 18,

Ndi chisamaliro

Chenjerani pakufunika kupereka mankhwala kwa anthu omwe ali ndi mbiri yakale ya:

kutupa
kuchepa magazi
kusokonezeka kwa minofu ya mtima.

Ndi matenda ashuga

Ngati mumagwiritsa ntchito mankhwalawa limodzi ndi ena othandizira kapena ma metformin, chithandizo chikuyenera kuyamba ndi mlingo wochepa, i.e. osapitilira 30 mg pa tsiku.

Kuphatikiza pamodzi ndi insulin kumaphatikizapo kugwiritsa ntchito limodzi mlingo wa Astrozone mu 15-30 mg patsiku, ndipo mlingo wa insulin umakhalabe womwewo kapena umachepa pang'onopang'ono, makamaka pankhani ya hypoglycemia.

Zotsatira zoyipa za Astrozone

Zimayambitsa zingapo zoyipa, zomwe zimatha kuchitika pakudya kosayenera kapena kuphwanya lamulo.

Astrozone imayambitsa kulephera kwa mtima.

Pafupifupi nthawi zonse, odwala amakhala ndi zotupa za malekezero. Kuwonongeka kwamawonekedwe kumatha kuphatikizidwanso ndi kusintha kwa kuchuluka kwa shuga m'magazi, makamaka kumayambiriro kwa chithandizo. Nthawi zina, kukula kwa mtima kulephera ndikotheka.

Zokhudza mphamvu pakuwongolera njira

Chifukwa Chifukwa chogwiritsa ntchito mankhwalawa, kukula kwa hypoglycemia ndikotheka, limodzi ndi chizungulire komanso kukwiya kwambiri, muyenera kukana kuyendetsa galimoto ndikuwongolera njira zina zovuta kuzimitsa. Vutoli likhoza kuthana ndi kuchuluka kwa zomwe zimachitika komanso kutsata.

Muyenera kukana kuyendetsa galimoto panthawi yamankhwala ndi Astrozone.

Malangizo apadera

Mosamala, mankhwala amalembedwa kwa odwala omwe ali pachiwopsezo cha edema, komanso opaleshoni (asanachitike opaleshoni). Matendawa amatha kuyamba (kutsika kwapang'onopang'ono mu hemoglobin nthawi zambiri kumalumikizidwa ndi kuchuluka kwa magazi omwe amayenderera m'mitsempha.

Kuwunika kuchuluka kwa hypoglycemia ndikofunikira mukamagwiritsa ntchito mankhwala limodzi ndi ketoconazole.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Kutenga mapiritsi ndi contraindicated pa bere komanso nthawi yoyamwitsa. Ngakhale zatsimikiziridwa kuti zinthu zomwe sizigwira ntchito sizikhala ndi mphamvu iliyonse pachonde, ndibwino kusiya njira yotereyi mukamakonzekera kubereka.

Kutenga mapiritsi a Astrozone kumapangidwira pakamwa.

Mankhwala osokoneza bongo a Astrozone

Palibe milandu ya bongo ya Astrozone yomwe idadziwika kale. Ngati mwangozi mwalandira mlingo waukulu wa mankhwalawa, zovuta zoyipa zomwe zimawonetsedwa ndi vuto la dyspeptic ndi kukula kwa hypoglycemia zitha kukulitsidwa.

Panthawi ya chizindikiro cha bongo, ndikofunikira kuchita mankhwala osokoneza bongo mpaka zotsekemera zonse zithe.

Ngati hypoglycemia iyamba kukulira, detoxification mankhwala ndi hemodialysis angafunike.

Ngati hypoglycemia imayamba ndi mankhwala osokoneza bongo a Astrozone, hemodialysis ingafunike.

Kuchita ndi mankhwala ena

Mukamagwiritsa ntchito limodzi ndi kulera kwapakamwa, kuchepa kwamphamvu kwa metabolites yogwira ntchito kumawonedwa. Chifukwa chake, kupambana kwa kugwiritsa ntchito njira zakulera kumachepetsedwa.

Njira ya pioglitazone metabolism mu chiwindi imakhala yotseka kwathunthu ngati imagwiritsidwa ntchito ndi ketoconazole.

Kuyenderana ndi mowa

Simungathe kuchita mankhwala ndi mankhwala ndikumwa mowa. Izi zitha kubweretsa zowonjezera pamagetsi. Chiwopsezo chokhala ndi dyspeptic phenomena chikuwonjezeka. Zizindikiro za kuledzera zikuchulukirachulukira.

Pali mitundu ingapo ya Astrozone analogues yomwe ili yofanana ndi izi malinga ndi zomwe zimagwira ntchito:

Diab Norm
Diaglitazone,
Amalvia
Phuli
Peoglite
Peouno

Tsiku lotha ntchito

Osapitilira zaka ziwiri kuchokera tsiku lopanga lomwe lasonyezedwa pa phukusi. Osagwiritsa ntchito kumapeto kwake.

Analogue ya Astrozone - mankhwala a piuno sangathe kugwiritsidwa ntchito kumapeto kwa tsiku lotha ntchito.

1 ml zikuchokera

Meloxicam - 6.00 mg

Othandizira: meglumine - 3,75 mg, poloxamer 188 - 50.00 mg, tetrahydrofurfuril macrogol (glycofurol) - 100.00 mg, glycine - 5.00 mg, sodium chloride - 3.00 mg, 1 M sodium hydroxide solution - kwa pH ya 8.2-8.9, madzi a jakisoni - mpaka 1 ml.

Ammoule amodzi (2,5 ml) ali ndi 15 mg ya meloxicam.

mandimu oyera achikasu.

Ndondomeko ya Astrozone

Oleg, wazaka 42, Penza

Kwa nthawi yayitali ndakhala ndikuvutika ndi matenda ashuga a 2. Mankhwala ambiri adayikidwa, koma mphamvu zake sizinatenge nthawi yomwe timafuna. Ndipo sizinali zotheka kwa ine kupanga jakisoni nthawi zonse. Ndipo pomwepo dotolo adandiwuza kuti ndimwe mapiritsi a Astrozone. Ndimamva kuthekera kwa iwo mwachangu mokwanira. Zinthu ziyamba kuyenda bwino. Kuchuluka kwa shuga m'magazi kungobwera kwawokha pakangotha milungu ingapo. Poterepa, piritsi limodzi ndi lokwanira tsiku lonse. Ndine wokhutira ndi zotsatira za mankhwalawo.

Andrey, wazaka 50, Saratov

Dotolo adayikira mapiritsi a Astrozone pa 15 mg patsiku chifukwa chakuti poyambira chithandizo panali mayeso oyipa a chiwindi. Koma kumwa koteroko sikunathandize. Dokotala adalimbikitsa kuwonjezera kuchuluka kwa 30 mg patsiku, yomwe idapereka zotsatira zomveka. Malinga ndi kusanthula, chizindikiro cha glucose chatsika. Zotsatira zake zidatenga nthawi yayitali mpaka mankhwala atachotsedwa. Mayeso ake atayamba kuipiraipira, adotolo adakhazikitsa mlingo wa 15 mg wa patsiku. Shuga akhala akugwira pafupifupi pafupifupi chaka chimodzi tsopano, chifukwa sindinganene chilichonse chokhudza mankhwalawa.

Peter, wazaka 47, Rostov-on-Don

Mankhwalawo sanakwane. Sindinamve chilichonse kuchokera ku mlingo woyambirira wa 15 mg. Malinga ndi zotsatira za kafukufukuyu, palibenso zosintha zapadera. Mankhwala atangowonjezereka mpaka 30 mg, zinthu zambiri zimangokulirakulira. Hypoglycemia yayikulu idayamba, zomwe zizindikiro zake zinkangondiperewera. Ndinayenera kusintha mankhwalawo.

Kutulutsa mawonekedwe, zikuchokera

Mankhwala amapezeka mu mawonekedwe a yankho la mu mnofu makonzedwe. Izi ndi meloxicam monga yogwira ntchito. 1 ml ya yankho lili ndi 6 mg ya meloxicam.

Monga zinthu zothandizira ndi glycine, sodium hydroxide, glycofurol, sodium chloride, madzi a jekeseni.

Chifukwa chosankha, mankhwala omwe amapezeka pang'onopang'ono amathandizira kukulitsa zotupa zam'mimba ndi duodenum.

Njira ya ntchito, Mlingo

Intramuscular makonzedwe a mankhwala amaloledwa masiku ochepa a mankhwala. Mtsogolomo, kusintha kwa mankhwalawa pakamwa (mapiritsi) ndikofunikira.

Mlingo wovomerezeka tsiku lililonse umachokera pa 7.5 mpaka 15 mg. Mulingo woyenera komanso nthawi ya mankhwalawa imatsimikiziridwa ndi dokotala, poganizira mawonetseredwe a matendawo ndi machitidwe a thupi la wodwalayo.

Odwala omwe ali ndi hemodialysis ndipo ali ndi mbiri yodwala kwambiri matenda a impso sayenera kupitilira muyeso wokwanira tsiku lililonse wa 7.5 mg.

Arthrosan sichikulimbikitsidwa kuti chisakanizidwe mu syringe yomweyo ndi mankhwala a magulu ena. Mothandizidwa ndi mtsempha wa magazi sikuvomerezeka.

Kuchita ndi magulu ena a mankhwala

Mankhwalawa ayenera kugwiritsidwa ntchito mosamala kwambiri akamagwiritsa ntchito nthawi yomweyo limodzi ndi mankhwala ochokera ku gulu la anticoagulants (Warfarin), antiplatelet agents (Plavix, Clopidogrel), mowa, piritsi ya corticosteroids (Prednisolone), Fluoxetine, Paroxetine.

Arthrosan sayenera kugwiritsidwa ntchito molumikizana ndi mankhwala ena ochokera ku gulu la mankhwala omwe si a antiidal.

Pogwiritsa ntchito munthawi yomweyo ndi okodzetsa, chiopsezo chokhala ndi kulephera kwa impso chikuwonjezeka.

Pogwiritsa ntchito nthawi yomweyo ndi mankhwala ochokera kuthamanga kwa magazi, mphamvu yawo yotsitsa imatha kuchepa.

Akaphatikizidwa ndi vitamini K, heparin, serotonin reuptake inhibitors, ndi fibrinolytics, chiopsezo cha kukha magazi chimakulanso.

Malangizo owonjezera

Ndi chitukuko cha kusintha kwa thupi komwe kumawonetsa kuphwanya kwa magwiridwe antchito a impso (kuyabwa ndi kutsekeka kwa khungu, kusanza, mkodzo wakuda, kupweteka pamimba), kugwiritsa ntchito mankhwalawa kuyenera kuyimitsidwa nthawi yomweyo ndikuyang'ana kwa dokotala.

Arthrosan ikhoza kumasuka kuwonetsa kwa matenda opatsirana.

Mankhwalawa sangathe kugwiritsidwa ntchito ngati prophylaxis ya thrombosis, ngakhale atha kuchepetsa kuphatikizana kwa mapulosi.

Mndandanda wa jakisoni Arthrosan

Mankhwala otsatirawa ndi fanizo la kukonzekera kwa Arthrosan: Melox, Amelotex, Mirlox, Mesipol, Movasin, Movalis. Ngati mukufunika kusintha mankhwalawa, muyenera kufunsa dokotala.

Kusunga jakisoni Arthrosan iyenera kuchitika m'malo amdima, yotetezedwa ku dzuwa lowonekera, kutali ndi ana. Kutentha kosungira - osaposa 25 digiri.

Pharmacodynamics ndi pharmacokinetics

Zogwira ntchito meloxicam- zotengera oksikama. Iwo ali odana ndi kutupa kwenikweni, kutseka kaphatikizidwema prostaglantins ndi enzyme chicoo oxygenase-2zomwe zimatenga nawo gawo arachidonic acid.

Mothandizidwa ndi meloxicam, ntchito oyimira pakati otupa ndi kupezeka makoma a mtimakutsika kwakukulu, braking amapezeka zimachitika ndi ma free radicals. Kuchita opaleshoni kumachitika chifukwa cha kuchepa kwa ntchito yolumikizana ndi ma prostaglantins ndipo mathero a mitsempha.

Khola lalitali limakwaniritsidwa masiku atatu mpaka asanu. Zimagwira bwino mapuloteni a plasma (99% ndi pamwambapa). Wopangidwiramu chiwindi, ndikupanga ma metabolites anayi. Sachita nawo gawo la mankhwala a pharmacodynamic. Ma metabolabol amatuluka mu ndowe ndi mkodzo kwa maola 15 mpaka 20.

Zizindikiro zogwiritsidwa ntchito

mu monotherapy mwa odwala (makamaka iwo onenepa kwambiri) omwe samakwanitsa kuwongolera glycemic potsatira kudya ndi kuchita masewera olimbitsa thupi omwe omwe oyang'anira metformin amatsutsana nawo,

kuphatikiza ndi metformin mwa odwala (makamaka onenepa kwambiri) omwe samakwanitsa kuwongolera glycemic motsutsana ndi kumbuyo kwa Mlingo wapamwamba kwambiri wa metformin,

kuphatikiza ndi sulfonylurea zotumphukira odwala omwe sangakwanitse kuwongolera glycemic motsutsana ndi kumbuyo kwa Mlingo wapamwamba wa sulfonylurea ndi komwe makina a metformin amatsutsana.

kuphatikiza ndi metformin ndi sulfonylurea zotumphukira odwala (makamaka iwo onenepa kwambiri) omwe samakwaniritsa kuwongolera kwa glycemic panthawi yophatikiza ndi metformin ndi zotumphukira za sulfonylurea,

osakanikirana ndi insulin odwala omwe samakwaniritsa kuwongolera glycemic panthawi yogwiritsira ntchito insulin ndi omwe makina a metformin amatsutsana nawo.

Malangizo ogwiritsira ntchito Arthrosan (Njira ndi Mlingo)

Mapiritsi amatengedwa kamodzi patsiku, pamodzi ndi chakudya, kutsukidwa ndi madzi. Mlingo wovomerezeka watsiku ndi tsiku umachokera pa 7.5 mg mpaka 15 mg, kutengera mphamvu ya ululu ndi matendawo.

Ngati mankhwalawa sangamwe pakamwaatha kusankha jekeseni wamitsempha.

Jekeseni wa Arthrosan, malangizo ntchito

Jakisoni wa arthrosan amaperekedwa kwa ululu wamatenda m'masiku ochepa oyamba a matenda. Mankhwala obayira kudzera m'mitsemphazakuya mu nsalu. Mlingo watsiku ndi tsiku umachokera pa 7.5 mpaka 15 mg, ndipo mankhwalawa amayamba ndi Mlingo wocheperako ndikuwonjezereka mpaka zotsatira zomwe mukufuna.

Musapitirire mlingo woyenera, mwina kuonjezera chiopsezo cha mavuto.

Mankhwala

Mankhwala

Meloxicam ndi mankhwala osagwiritsa ntchito mankhwala a anti-yotupa (NSAID), amatanthauza za zotumphukira za ency acid ndipo zimakhala ndi anti-yotupa, analgesic ndi antipyretic. The kutchulidwa odana ndi kutupa zotsatira za meloxicam amakhazikitsidwa pa onse muyezo zitsanzo zotupa. Limagwirira zake meloxicam ndi luso lake poletsa kaphatikizidwe ka prostaglandins, odziwika oteteza okhazikika. Mu vivo meloxicam amalepheretsa Prostaglandin kaphatikizidwe pamalo a kutupa kwambiri pamlingo wopezeka m'matumbo kapena impso.

Kusiyana kumeneku kumalumikizidwa ndi chopinga chosankha cha cycloo oxygenase-2 (COX-2) poyerekeza ndi cycloo oxygenase-1 (COX-1). Amakhulupirira kuti kuletsa kwa COX-2 kumawonetsa zochizira za NSAIDs, pomwe zoletsa za COX-1 isoenzyme zomwe zimapezeka nthawi zonse zimatha kuyambitsa mavuto kuchokera m'mimba ndi impso. Kusankhidwa kwa meloxicam pokhudzana ndi COX-2 kumatsimikiziridwa mumayendedwe osiyanasiyana oyesera, onse mu vitro ndi vivo. Kuthekera kosankha kwa meloxicam poletsa COX-2 kukuwonetsedwa pogwiritsa ntchito magazi athunthu a vitro ngati njira yoyeserera.

Zinakhazikitsidwa kuti meloxicam (pa Mlingo wa 7.5 ndi 15 mg) yogwira kwambiri COX-2, ikuwonjezera mphamvu kwambiri pakupanga kwa prostaglandin E2 yolimbikitsidwa ndi lipopolysaccharide (zomwe zimayang'aniridwa ndi COX-2) kuposa kupanga kwa thromboxane, komwe kumakhudzana ndikuwunda kwa magazi. (zomwe zimayendetsedwa ndi COX-1).Izi zimadalira mlingo. Kafukufuku wa Ex vivo awonetsa kuti meloxicam (pa Mlingo wa 7.5 mg ndi 15 mg) ilibe gawo pakukhudzana kwa kupatsidwa kwa magazi ndi nthawi ya magazi.

M'maphunziro azachipatala, zotsatira zoyipa kuchokera m'matumbo am'mimba (GIT) yonseyi idawuka pafupipafupi mukamamwa meloxicam 7.5 ndi 15 mg kuposa mukamatenga ma NSAID ena omwe kuyerekezerako kunachitika. Kusiyana kumeneku kwa zotsatira zoyipa kuchokera m'matumbo am'mimba makamaka chifukwa chakuti mukamamwa meloxicam, nthawi zambiri simumawona zochitika monga dyspepsia, kusanza, mseru, kupweteka m'mimba. Pafupipafupi mafuta onunkhira am'matumbo am'mimba, zilonda zam'mimba komanso magazi, omwe anali ogwirizana ndi kugwiritsa ntchito meloxicam, anali otsika ndipo amadalira mlingo wa mankhwalawo.

Pharmacokinetics

Meloxicam kwathunthu odzipereka pambuyo mu mnofu makonzedwe. Achibale bioavailability poyerekeza mkamwa bioavailability pafupifupi 100%. Chifukwa chake, mukasintha kuchokera ku jekeseni kupita pakamwa pakusankha kwa mankhwala sikofunikira. Pambuyo pa kutumikiridwa kwa 15 mg ya mankhwalawa intramuscularly, ndende ya plasma ndende (pafupifupi 1.6 - 1.8 μg / ml) imafika pafupifupi 60 - 96 mphindi.

Meloxicam imamangiriza bwino mapuloteni a plasma, makamaka ndi albumin (99%). Imalowa mu madzi a synovial, ndende yomwe imalowa mu madzi a synovial pafupifupi 50% ya ndende ya plasma. Kuchuluka kwa magawo kumakhala kotsika, pafupifupi malita 11. Kusiyanitsa kwamunthu ndi 7-20%.

Meloxicam pafupifupi imapukusidwa kwathunthu mu chiwindi ndi mapangidwe a 4 omwe amagwiritsidwa ntchito mosiyanasiyana. Metabolite yayikulu, 5-carboxy-meloxicam (60% ya mlingo), imapangidwa ndi makutidwe a oxidation a metabolite apakati, 5-hydroxymethylmeloxicam, amenenso amatulutsidwa, koma pang'ono (9%). Kafukufuku wa in vitro awonetsa kuti CYP2C9 isoenzyme imagwira ntchito yofunika kwambiri pakusintha kwa metabolic iyi, ndipo CYP3A4 isoenzyme imachita mbali inanso. Popanga metabolites ena awiri (kupanga, motero, 16% ndi 4% ya mlingo wa mankhwalawa), peroxidase imakhudzidwa, ntchito yomwe mwina imasiyanasiyana. Kuswana

Imafukusidwa chimodzimodzi m'matumbo ndi impso, makamaka mu mawonekedwe a metabolites. Mwanjira yosasinthika, osakwana 5% ya mlingo wa tsiku ndi tsiku amatulutsidwa ndowe, mkodzo mwa mawonekedwe osasinthika, mankhwalawa amapezeka pokhapokha akutsatira. Pafupifupi theka moyo wa meloxicam umasiyana 13 mpaka 25 maola. Plasma chilolezo pafupifupi 7-12 ml / mphindi pambuyo kamodzi. Meloxicam amawonetsa ozungulira a pharmacokinetics mu Mlingo wa 7.5-15 mg ndi intramuscular system.

Kuperewera kwa chiwindi ndi / kapena ntchito ya impso

Kuperewera kwa chiwindi, komanso kulephera kupweteka kwa aimpso, sikukhudza kwambiri pharmacokinetics ya meloxicam. Mlingo wa kuthetseratu kwa meloxicam m'thupi ndiwokwera kwambiri mwa odwala omwe amalephera kusintha aimpso. Meloxicam sangagwirizane ndi mapuloteni a plasma mwa odwala omwe ali ndi vuto laimpso. Mu kulephera kwa aimpso, kuwonjezeka kwa kuchuluka kwa magawidwe kumatha kuyambitsa kukwera kwa meloxicam yaulere, kotero mwaodwala awa tsiku lililonse sayenera kupitirira 7.5 mg.

Odwala okalamba poyerekeza ndi odwala achichepere ali ndi magawo ofanana a pharmacokinetic. Odwala okalamba, kuchuluka kwa plasma panthawi yofanana ya pharmacokinetics kumakhala kotsika poyerekeza ndi kwa achinyamata achinyamata. Amayi okalamba ali ndi mfundo zapamwamba za AUC (dera lomwe limakhala munthawi yopondera) komanso kutalikirana kwa theka, poyerekeza ndi odwala achichepere onse amuna.

Mlingo ndi makonzedwe

Osteoarthritis ndi ululu: 7.5 mg patsiku. Ngati ndi kotheka, mankhwalawa akhoza kuchuluka mpaka 15 mg patsiku.

Rheumatoid nyamakazi: 15 mg patsiku. Kutengera ndi zochizira, mankhwalawa amatha kuchepetsedwa mpaka 7.5 mg patsiku.

Ankylosing spondylitis: 15 mg patsiku. Kutengera ndi zochizira, mankhwalawa amatha kuchepetsedwa mpaka 7.5 mg patsiku.

Odwala omwe ali ndi chiopsezo chowonjezeka (mbiri yakale ya matenda ammimba, kupezeka kwa zinthu zomwe zimayambitsa matenda a mtima), tikulimbikitsidwa kuti ayambe kulandira chithandizo cha mankhwala a 7.5 mg patsiku (onani gawo "Malangizo Apadera"). Odwala kwambiri aimpso kulephera hemodialysis, mlingo sayenera upambana 7.5 mg patsiku.

Malangizo onse

Popeza chiopsezo chotsatira chododometsa chimatengera mlingo komanso nthawi yayitali ya chithandizo, muyenera kugwiritsira ntchito mlingo wotalikira komanso nthawi yayitali yogwiritsidwa ntchito. Pazipita la tsiku lililonse lofika 15 mg.

Ntchito zophatikizika

Simuyenera kugwiritsa ntchito mankhwalawa nthawi imodzi ndi ena a NSAID. Mlingo wa tsiku ndi tsiku wa mankhwala Arthrosan® omwe amagwiritsidwa ntchito mosiyanasiyana mitundu sayenera kupitirira 15 mg.

Mgwirizano makonzedwe a mankhwala akusonyezedwa pokhapokha masiku ochepa a mankhwala. Mankhwala ena amapitilizidwa pogwiritsa ntchito mitundu ya pakamwa. Mlingo wovomerezeka ndi 7.5 mg kapena 15 mg 1 nthawi patsiku, kutengera kulimba kwa ululu ndi kuuma kwa njira yotupa.

Mankhwalawa amathandizidwa ndi jakisoni wambiri wamitsempha.

Mankhwala sangathe kutumikiridwa kudzera m'mitsempha.

Popeza kungafanane kwa Arthrosan, njira yothetsera makulidwe a mu mnofu sayenera kusakanikirana ndi syringe yomweyo ndi mankhwala ena.

Zotsatira zoyipa

Zotsatira zoyipa zikufotokozedwa pansipa, ubale womwe umagwiritsidwa ntchito ndi meloxicam udawonedwa kuti ndiotheka.

Zotsatira zoyipa zolemba pambuyo pogulitsa, ubale womwe umagwiritsidwa ntchito ndi meloxicam umawoneka kuti ungatheke, walembedwa ndi *.

Gawo lotsatirali limagwiritsidwa ntchito mkati mwa magulu a ziwalo zolingana ndi kuchuluka kwa mavuto:

Nthawi zambiri (> 1/10),
Nthawi zambiri (> 1/100. 1 / 1,000. 1 / 10,000. Kusokonezeka kwa magazi ndi dongosolo la zamitsempha yamagazi:

Pafupipafupi - leukopenia, thrombocytopenia, amasintha kuchuluka kwa maselo amwazi, kuphatikiza kusintha kwamatsitsi a leukocyte.

Matenda owononga chitetezo chamthupi:

Nthawi zambiri, zochita zina zamtundu wa hypersensitivity *, sizipezeka - anaphylactic shock *, anaphylactoid reaction. Mavuto am'malingaliro: Kawirikawiri - kusintha kwa maganizo kumachitika *,

Osakhazikitsidwa - chisokonezo *, chisokonezo *. Kusokonezeka kwa dongosolo lamanjenje: Nthawi zambiri - kupweteka mutu, pafupipafupi - chizungulire, kugona.

Kuphwanya ziwalo za masomphenyawo, makutu ndi makina olembetsa: pafupipafupi - vertigo,

Pafupipafupi - conjunctivitis *, kuwonongeka kowonekera, kuphatikizapo kusawona bwino, tinnitus. Kuphwanya kwa mtima ndi mitsempha yamagazi:

Pafupipafupi - kuchuluka kwa kuthamanga kwa magazi, kumverera kwa "kuthamanga" kwa magazi kumaso, kawirikawiri - kugunda kwa mtima.

Kuphulika kwa dongosolo la kupuma:

Pafupipafupi - mphumu ya bronchial mwa odwala omwe amasiyana ndi acetylsalicylic acid ndi ena a NSAID.

Kuphwanya kwa e / m'mimba thirakiti: Nthawi zambiri - kupweteka kwam'mimba, kukomoka, kutsegula m'mimba, kusanza, kusanza,

Kanthawi kochepa - magazi am'mimba kapena owonekera m'mimba, gastritis *, stomatitis, kudzimbidwa, kutulutsa, kuyeretsa, Pafupipafupi - zilonda zam'mimba, colitis, esophagitis, kawirikawiri - kufukiza kwam'mimba thirakiti. Kuphwanya chiwindi ndi chindapusa:

Nthawi zambiri - kusintha kwakanthawi kwamankhwala othandizira chiwindi (mwachitsanzo, kuchuluka kwa transaminases kapena bilirubin), kawirikawiri - hepatitis *.

Zovuta za pakhungu ndi minofu yolowera: Mosachepera - angiotek *, kuyabwa, zotupa pakhungu,

Pafupifupi kawopsedwe ka khungu la m'magazi *, matenda a Stevens-Johnson *, urticaria,

Osowa kwambiri - bulty dermatitis *, erythema multiforme *, Sipezeka - photosensitivity.

Kuphwanya impso ndi kwamikodzo thirakiti:

Pafupipafupi - kusintha kwa kuwonetsa kwa impso (kuchuluka kwa creatinine ndi / kapena urea m'mitsempha yamagazi), kusokonekera kwamikodzo, kuphatikiza kwamikodzo kwamikodzo posungira *,

Osowa kwambiri - kulephera kwa impso *.

Kuphwanya maliseche ndi zofunsitsa za mamisala:

Nthawi zambiri - ovulation mochedwa *,

Osakhazikitsidwa - kusabereka mwa akazi *.

Zovuta ndi zovuta zina pamalo opangira jakisoni:

Nthawi zambiri - kupweteka ndi kutupa pamalo a jakisoni,

Kugwiritsa ntchito palimodzi ndi mankhwala omwe amalepheretsa mafupa (mwachitsanzo methotrexate) kungayambitse cytopenia.

Kutulutsa magazi m'mimba, zilonda zam'mimba, kapena kupangika kumatha kupha.

Nkhani zina za NSAID, sizimapatula mwayi wofanana ndi wa nephritis wapakati, glomerulonephritis, aimpso medullary necrosis, ndi nephrotic syndrome.

Kuchita ndi mankhwala ena

Zina zoletsa za kaphatikizidwe ka prostaglandin, kuphatikizapo glucocorticoids ndi salicylates, kugwiritsa ntchito pamodzi ndi meloxicam kumawonjezera chiopsezo cha zilonda zam'mimba komanso magazi am'mimba (chifukwa cha synergism of action). Kugwiritsa ntchito limodzi ndi ena a NSAID sikulimbikitsidwa. Maanticoagulants pakamwa, heparin yogwiritsidwa ntchito mwa makina, othandizira a thrombolytic - munthawi yomweyo kugwiritsa ntchito meloxicam kumawonjezera mwayi wokhetsa magazi. Ngati mukugwiritsa ntchito munthawi yomweyo, kuyang'anira bwino njira zopangira magazi ndikofunikira.

Mankhwala a antiplatelet, serotonin reuptake inhibitors, kugwiritsidwa ntchito kofanana ndi meloxicam kumawonjezera chiopsezo chotaya magazi chifukwa chopewera kupatsidwa zinthu za m'magazi. Ngati mukugwiritsa ntchito munthawi yomweyo, kuyang'anira bwino njira zopangira magazi ndikofunikira.

Kukonzekera kwa Lithium - NSAIDs imakulitsa kuchuluka kwa lifiyamu mu plasma pochepetsa kuchotsa kwa impso. Kugwiritsa ntchito nthawi yomweyo kwa meloxicam ndi kukonzekera kwa lifiyamu sikulimbikitsidwa. Ngati ndi kotheka, munthawi yomweyo kugwiritsa ntchito analimbikitsa kuyang'anira kusamala ndende ya lifiyamu plasma nthawi yonse ya kukonzekera lifiyamu.

Methotrexate - NSAIDs imachepetsa kubisalira kwa methotrexate ndi impso, potero imakulitsa kuchuluka kwake kwa plasma. Kugwiritsa ntchito pamodzi kwa meloxicam ndi methotrexate (pa mlingo woposa 15 mg pa sabata) sikulimbikitsidwa. Ngati mukugwiritsa ntchito munthawi yomweyo, kuyang'anira kuwonongeka kwa aimpso ndi kuchuluka kwa magazi ndikofunikira. Meloxicam akhoza kuonjezera hematologic kawopsedwe wa methotrexate, makamaka kwa odwala mkhutu aimpso ntchito.

Kulera - pali umboni kuti NSAIDs ingachepetse kugwira ntchito kwa zida zamkati mwa intrauterine, koma izi sizinatsimikizidwe.

Diuretics - kugwiritsa ntchito kwa NSAIDs ngati madzi atha kumayendera limodzi ndi ngozi yovuta yaimpso.

Ma antihypertensive othandizira (beta-blockers, angiotensin-akatembenuza enzyme inhibitors, vasodilators, diuretics). NSAIDs amachepetsa mphamvu ya antihypertensive mankhwala, chifukwa chopinga cha ma prostaglandins okhala ndi masodilating katundu.

Angiotensin II receptor antagonists, komanso angiotensin-kutembenuza ma enzyme atagwiritsidwa ntchito limodzi ndi NSAIDs, kumawonjezera kuchepa kwa kusefukira kwa glomerular, komwe kumatha kuyambitsa kukula kwa impso kulephera, makamaka kwa odwala omwe ali ndi vuto laimpso.

Colestyramine, womangidwa kwa meloxicam m'mimba, amatsogolera ku chimbudzi chake mwachangu.

Pemetrexed - munthawi yomweyo kugwiritsa ntchito meloxicam ndi pemetrexed kwa odwala omwe ali ndi 45 mpaka 79 ml / min, meloxicam iyenera kuthetsedwa masiku asanu isanayambike kwa pemetrexed ndipo itha kuyambiranso masiku awiri atatha kumwa kwa mankhwalawa. Ngati pakufunika kugwiritsidwa ntchito kophatikizira kwa meloxicam ndi pemetrexed, ndiye kuti odwala oterowo ayenera kuyang'aniridwa mosamala, makamaka zokhudza myelosuppression komanso kupezeka kwa zotsatira zoyipa kuchokera m'matumbo am'mimba. Odwala ndi creatinine chilolezo zosakwana 45 ml / min, kutenga meloxicam palimodzi ndi pemetrexed osavomerezeka.

NSAIDs, yogwiritsa ntchito impso prostaglandins, imatha kukulitsa cyclosporin nephrotoxicity.

Mukagwiritsidwa ntchito molumikizana ndi mankhwala a meloxicam omwe amatha kudziletsa CYP 2C9 ndi / kapena CYP ZA4 (kapena atapangidwa ndi ma enzymes awa), monga sulfonylureas kapena probenecid, mwayi wothandizirana ndi pharmacokinetic uyenera kukumbukiridwa. Akaphatikizidwa ndi antidiabetesic othandizira pakamwa (mwachitsanzo, zotumphukira za sulfonylurea, nateglinide), kuchitirana pakati ndi CYP 2C9 ndizotheka, zomwe zingayambitse kuchuluka kwa mankhwalawa komanso meloxicam m'magazi. Odwala omwe akutenga meloxicam ndi sulfonylurea kapena nateglinide kukonzekera amayenera kuwunika magazi awo mosamala chifukwa cha hypoglycemia.

Pogwiritsa ntchito munthawi yomweyo maantacid, cimetidine, digoxin ndi furosemide, palibe zochitika zamtundu wa pharmacokinetic zomwe zapezeka.

Mlingo ndi makonzedwe

Jekeseni ndi Arthrosan amagwiritsidwa ntchito masiku ochepa okha a mankhwala kamodzi pa tsiku, pa 7.5 kapena 15 ml, pambuyo poti chithandizo chimapitilizidwa ndi mapiritsi. Chifukwa cha chiwopsezo cha mavuto, tikulimbikitsidwa kugwiritsa ntchito mankhwalawa. Jekeseni ndi Arthrosan amayenera kuperekedwa kokha mu intramuscularly ndipo osavomerezeka kusakaniza mankhwalawa syringe imodzi ndi mankhwala ena.

Mapiritsi a Arthrosan amatengedwa kamodzi patsiku, makamaka ndi zakudya. Mlingo wambiri watsiku ndi tsiku ndi 15 mg. Mlingo umatengera matenda:

Ndi osteoarthrosis, piritsi limodzi la Artrozan 7.5 mg, pakakhala kuti palibe vuto, mankhwalawa amatha kuchulukitsidwa,
Mlingo wovomerezeka tsiku lililonse wa nyamakazi ndi 15 mg, mutatha kusintha, muyezo umachepetsedwa mpaka 7.5 mg patsiku,
Ndi ankylosing spondylitis, piritsi limodzi la Arthrosan 15 mg tsiku lililonse.

Malinga ndi malangizo opita ku Arthrosan, ngati muledzera kwambiri, kupweteka kwa epigastric, kusokonezeka kwa chikumbumtima, nseru, kumangidwa kwa kupuma, kusanza, kupweteka kwaimpso ndi kwa hepatic, asystole imatha.

Muyenera kusamala mukamagwiritsa ntchito Arthrosan ndi mankhwala a antihypertensive, methotrexate, diuretics, cyclosporine, kukonzekera kwa lithiamu, ndi mankhwala ena. Chiwopsezo chotaya magazi kuchokera m'matumbo am'mimba chimawonjezeka ndikugwiritsira ntchito pamodzi kwa Arthrosan ndi mankhwala ena osagwirizana ndi antiidal, kuphatikizapo acetylsalicylic acid.

Arthrosan amagwiritsidwa ntchito mosamala ngati zotupa ndi zotupa zam'matumbo zimagona mu anamnesis ndi ukalamba.

Ndemanga za Arthrosan

Ndemanga za jakisoni wa Arthrosan ndiabwino. Mankhwalawa ndi otsika mtengo komanso ogwira mtima. Ambiri adathandiza kuthana ndi kupweteka ndi matenda osiyanasiyana olowa. Kumwa mapiritsi kumakhala ndi zofanana ndi jakisoni. Mwa minus, zoyipa zimadziwika mu mawonekedwe am'mutu, kupweteka m'mimba ndi chizungulire, koma izi zimachitika pafupipafupi.