Mapiritsi a Emoxipin: malangizo ogwiritsira ntchito

Emoxipine (INN - Emoxipine) ndi angioprotector amene amachepetsa kukula kwa zotumphukira kwamitsempha chifukwa cha kuthamanga kwa njira zosinthira, komanso mankhwalawa ndi antioxidant ndi antihypoxant. Emoxipin amachepetsa kukhuthala kwa magazi, kupuma kwamitsempha, komanso chizolowezi chotupa. Kuphatikiza apo, zosakaniza zomwe zimagwiritsidwa ntchito ndi mankhwalawa zidzakulitsa ma cyclic nucleotides m'mitsempha yamaubongo ndi m'mitsempha yamagazi.

Fibrinolytic ntchito ya mankhwala akuwonetseredwa kuti nthawi yovuta vuto la mtima, njirayi imatha kukulitsa ziwiya zama coroni, potero zimachepetsa chidwi chake necrosis. Komanso, kukhoza komanso kulekera kwina kwa mtima kumatha.

Monga ophthalmic chinthu, Emoxipin ali ndi retinoprotective katundu, amateteza diso la misozi chifukwa cha mphamvu zowala kwambiri. Madontho a Emoksipin athandizira kuthetsa mtsempha wamagazi hemorrhage ndikonzanso kusintha kwa ma cellcirculation m'maso.

Pharmacodynamics ndi pharmacokinetics

Mankhwala

Zotsatira zabwino pa magazi: Pochepetsa chiwonetsero chonse cha kuphatikiza ndi kutsitsa kuphatikiza kwa maselo, mankhwalawa amakulitsa nthawi ya magazi. Nembanemba yama cell ndi mitsempha yamagazi mothandizidwa ndi mankhwala, maselo ofiira amwazi kuwonjezera kukana kwawo hemolysis komanso kuvulala kwamakina.

Kuletsa zoletsa zaulere-makulidwe amakupanga wa lipids omwe ali biomembranes. Kuchulukitsa kwa ma enzymes omwe amachititsa ntchito ya antioxidant. Wokhoza kupereka lipid-kutsitsa kwenikweni mwa kuchepetsa kapangidwe ka triglycerides.

Kulandila kwa Emoksipin amatha kuchepetsa kuwonetsa matenda hemodysfunction. Zimakhala ndi zotsatira zabwino pakukhazikika kwa kortortal cortex kuti ischemia ndi hypoxia. Zowongolera zochitika zapazinthu zachuma pa ngozi ya ubongo.

Emoxipin ali ndi tanthauzo la mtima. Mtima wamtima udzatetezedwa ngati myocardial ischemic kuvulala: Mankhwalawa amalepheretsa kugawidwa kwake, komanso kukulitsa zombo za coronary.

Monga Diso likugwera Emoxipin amateteza retina kuti isawonongeke chifukwa chogwiritsa ntchito kuwala kozama. Kuphatikiza apo, chifukwa cha mankhwalawa, kuyambiranso kwamatumbo mkati mwa diso ndikotheka.

Pharmacokinetics

Pankhani ya mtsempha wa magazi 10 mg pa kilogalamu imodzi ya kulemera kwa odwala, otsika kwambiri amadziwika Kutha kwa mankhwalawa. Kuchotsa kosaletseka ndi 0,041 min, kuchuluka komwe kumagawidwa ndi 5.2 l, chilolezo chokwanira ndi 214.8 ml pamphindi.

Mankhwalawa amalowa mosavuta ziwalo ndi thupi la munthu ndipo ndimomwe zimachitikira kagayidwe.

Ma pharmacokinetics a Emoxipin amatha kusiyanasiyana malinga ndi momwe wodwalayo alili. Mwachitsanzo, pankhani yodwala matenda coronary occlusion, liwiro lomwe mankhwalawo amachotseredwa, lidzachepetsedwa, kotero kuti lipezekenso.

Pankhani ya kubwezeretsanso kwa Emoxipine, zosakaniza za mankhwala zimawoneka nthawi yomweyo m'magazi, khola lalitali limapitirira kwa maola awiri, ndipo pambuyo pa maola 24 pambuyo pa utsogoleri, kufunsa kwa oyang'anira kumakhala pafupifupi kulibe konse m'magazi. Kuphatikizika kwina kwa mankhwalawa kumasungidwa m'maso.

Zisonyezero zogwiritsira ntchito Emoxipin

Monga Diso likugwera Zomwe zikugwiritsidwa ntchito ndi:

mtsempha wamagazi hemorrhage,
thrombosis m'mphepete mwenimweni mwa khungu la nthambi yamanja ndi nthambi zake.
glaucoma,
chitetezo cha retina pambuyo laser coagulation ndi kuwala kwamphamvu kwambiri (pakuwotcha kadzuwa ndi laser).

Zizindikiro zogwiritsidwa ntchito Jakisoni wa Emoxipin:

Komanso, jakisoni wa Emoxipin amagwiritsidwa ntchito ngati mukudwala kwambiri komanso pachimake ngozi yamitsemphangati choyambitsa mavutowa ndi hemorrhagic ndi ischemic matenda. Ngati ndi kotheka, mankhwalawa amatha kuperekedwa ngati jakisoni wamkati, kapena jekeseni wamkati mwa ma ampoules.

Zotsatira zoyipa

Zosiyanasiyana zimachitika wokongolaamene patapita nthawi yochepa adzasinthidwa kugona. Mwina kuchuluka kwa kuthamanga kwa magazi ndi mawonekedwe zotupa. Zomwe zimachitika m'deralo zimatha kuwonetsedwa ndi zowawa, kuyabwa, kutentha kwa moto, redness ndi kulimbitsa minofu ya paraorbital.

Malangizo a Emoxipin (Njira ndi Mlingo)

Malangizo a Emoxipin - madontho amaso

Pankhani ya kuyambiranso kwa mankhwalawa, peresenti imodzi mu theka la 0,5 ml imaperekedwa 1 kamodzi patsiku kwa masiku 10-15. Ngati mankhwalawa amathandizidwa ndi subconjunctival ndi parabulbar, ndiye kuti kuchokera ku 0,5 mpaka 0,5 ml ya mankhwalawa amaperekedwa kamodzi patsiku kwa masiku 10-30.

Ngati n`kofunika kuteteza ocular retina, mankhwala kutumikiridwa retrobulbarly mu Mlingo wa 0,5 ml patsiku ndi ola limodzi pamaso laser coagulation. Maphunzirowa amatengera kuchuluka kwa kupsa komwe amalandila nthawi ya laser, nthawi zambiri, madontho amagwiritsidwa ntchito mobwerezabwereza kamodzi patsiku kuyambira masiku awiri mpaka khumi.

Malangizo a Emoxipin - jakisoni

Mu cardiology ndi neurology, mankhwalawa amagwiritsidwa ntchito kwambiri pamitsempha ndi dontho pamtengo wa madontho 20-40 pamphindi. Mlingo wa mankhwalawa ndi 20-30 ml ya atatu peresenti yankho. Madontho amatha kuperekedwa kuyambira kamodzi mpaka katatu patsiku kwa masiku 5-15. Kutalika kwa chithandizo kumatengera mtundu wa matenda. Pamapeto pa otsikira, amasinthana ndi jakisoni wa mankhwala: 3-5 ml ya yankho la 3% amadzibayira katatu patsiku. Njira ya jakisoni wa mu mnofu imayambira masiku 10 mpaka 30.

Emoxipin samamasulidwa piritsi, chifukwa sungatenge mapiritsi a Emoxipin, chifukwa kulibe.

Bongo

Pankhani ya mankhwala osokoneza bongo ambiri, kuwoneka kapena kulimba kwa zotsatira zoyipa ndikotheka. Ndi mankhwala osokoneza bongo kapena mawonekedwe ake, amatha kuchuluka kuthamanga kwa magazikukwiya kwambiri kapena kugona, kupweteka mumtima, kupweteka mutu, nserukusasangalala m'mimba. Kuphatikizika kwa magazi kumatha kusokonezeka.

Chithandizo cha bongo wa Emoxipin ndi analogies a Emoxipin ndiko kusiya mankhwalawa ndikuwonetsa njira zochizira, ngati pakufunika.

Kuchita

Pankhani ya ntchito limodzi ndi α-tocopherol acetate, mwina kuwonetsa kwambiri kwa antioxidant katundu wa Emoxipin. Mwambiri, kumwa mankhwalawa osavomerezeka kuti aphatikizidwe ndi mankhwala ena alionse popanda chilolezo kuchokera kwa dokotala.

Pharmacokinetics

Mukamayendetsa pa 10 mg / kg, nthawi yotsiriza ya Ti / g ndi mphindi 18, chilolezo chonse cha CI ndi 0,2 l / min, ndipo kuchuluka kogawidwa kwa Vd ndi 5.2 l.

Mankhwalawo amalowa mwachangu ziwalo ndi minyewa, pomwe imayikiridwa ndikuwupangika. Ma metabolites asanu a emoxipin, omwe amaimiridwa ndi dealkylated komanso ophatikizika pazinthu zomwe adatembenuza, adapezeka. Emoxipin metabolites amathandizidwa ndi impso. Mitundu yayikulu ya 2-ethyl-6-methyl-3-hydroxypyridine-phosphate imapezeka m'chiwindi.

M'mikhalidwe ya pathological, mwachitsanzo, pankhani ya corlary occlusion, pharmacokinetics ya emoxipin amasintha. Mlingo wa chimbudzi umachepa, nthawi yomwe amagwiritsidwa ntchito ndi emoxipin m'magazi amawonjezereka, zomwe mwina zimachitika chifukwa chobwerera kuchokera ku depot, kuphatikizapo ku ischemic myocardium.

Tsiku lotha ntchito

Zaka zitatu kuyambira tsiku lomasulidwa.

Emoxipin ndi njira yothandiza kwambiri yamakono. Chokhacho chomwe chingabwezeretse ndikukwiya kwam'deralo mukamagwiritsa ntchito. Anthu omwe ali ndi vuto lalikulu la maso amatha kusiya ndemanga zabwino za Emoxipine, chifukwa amatsatira malangizo a dotolo ndipo, chifukwa cha zovuta zake, amadziwa bwino kufunika kwa chithandizo. Ngati mankhwalawa agwiritsidwa ntchito pochiza matenda ang'onoang'ono ophthalmic, ndiye kuti ndemanga za madonthowo sizikhala zabwino: chidziwitso nchakuti si aliyense amene ali wokonzeka kupirira zosakhalitsa zoyaka moto akamva mankhwalawo.

Madokotala amawunika za Diso likugwera - zabwino kwambiri. Mankhwalawa amalimbana ndi ntchito yake, ngakhale imayambitsa kusakhalitsa kwakanthawi kwa odwala.

Emoxipin jakisoni mutha kuthana ndi zovuta zam'mutu komanso vuto la mtima kwa odwala ambiri padziko lonse lapansi. Komanso kumwa mankhwalawa kwakanthawi kumathandiza kuchepetsa ziwonetsero zingapo zamavuto am'thupi. Ndizomveka kuti chidziwitso chabwino chogwiritsa ntchitochi chimawonetsedwa mu ndemanga zabwino, kuchokera kwa odwala komanso madokotala.

Mtengo wa Emoxipin, komwe mungagule

Mutha kugula Emoxipin ku Kiev popanda mavuto: mankhwalawa kapena mawonekedwe ake amatha kupezeka mufesi iliyonse. Ndizomwe mtengo wake ungasiyane pang'ono kutengera kupazi, komabe, pafupifupi madontho onse amaso ku Ukraine, ndipo mankhwala ena amasiyana pamtengo. Zimangotengera malire a mankhwala pa mankhwalawo, komanso malo omwe amapangidwira, kumasulidwa kwambiri, ndi zina zambiri.

Mtengo wapakati Diso limagwera emoxipin 1% mu botolo 5 ml amasintha pamsika kuzungulira 60 UAH. Phukusi la ma ampoules asanu 1 ml ya 1 peresenti Emoksipin No. 10 adzagula pafupifupi 50 UAH mu pharmacy.