Momwe mungagwiritsire ntchito mankhwala amitriptyline?

Amitriptyline

Pake wa mankhwala
IUPAC	5- (3-Dimethylaminopropylidene) -10,11-dihydrodibenzocycloheptene
Choyimira chokha	C₂₀H₂₃N
Unyinji wa Molar	277,403 g / mol
Cas	50-48-6
PubChem	2160
Drugbank	APRD00227
Gulu
ATX	N06AA09
Pharmacokinetics
Bioava	30—60 %
Kupenda	Chiwindi
Hafu ya moyo.	10-26 h
Kupatula	Impso
Mlingo Wamitundu
mapiritsi (dragees) 10, 25, 50, 75 mg, kupumira makapisozi 50 mg, 1% yankho mu ampoules, 2 ml.
Njira zoyendetsera
mkati, kudzera m'mitsempha, mtsempha
Mayina ena
Amitriptyline, Amizol, Amirol, Saroten retard, Triptisol, Elivel, Amineurin, Apo-Amitriptyline, Novo-Triptin, Adepren
Wikimedia Commons Media Mafayilo

Amitriptyline (lat. Amitriptylinum) - m'modzi wa oimira ma tridclic antidepressants, limodzi ndi imipramine ndi clomipramine. Amitriptyline ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda angapo amisala: kukhumudwa ndi nkhawa, zochepa, kusamalira chidwi ndi vuto la kupuma. Zizindikiro zina zimaphatikizira migraine prophylaxis, chithandizo cha ululu wa neuropathic monga fibromyalgia ndi postherpetic neuralgia, komanso kusowa tulo kwenikweni. Mankhwalawa ndi a gulu la ma tricyclic antidepressants (TCAs), ndipo momwe amagwirira ntchito sanadziwike bwino. Amitriptyline amawonetsedwa pakamwa komanso ngati jakisoni.

Zotsatira zoyipazi zimaphatikizapo kuwona kwamaso, mkamwa youma, kuthamanga kwa magazi mutayimirira, kugona, komanso kudzimbidwa. Zotsatira zoyipazi zimatha kuphatikizira kukomoka, chiwopsezo chodzipha mwa anthu osaposa zaka 25, kusungika kwamikodzo, glaucoma, ndi mavuto angapo amtima. Amitriptyline sayenera kumwedwa ndi Mao zoletsa kapena ndi mankhwala osokoneza bongo a cosapride. Amitriptyline imatha kubweretsa zovuta ngati itengedwa pa nthawi ya pakati. Kugwiritsa ntchito yoyamwitsa kumawoneka kotetezeka.

Amitriptyline idapezeka mu 1960 ndipo idavomerezedwa ndi U.S. Food and Drug Administration (FDA) mu 1961. Amapezeka ngati mankhwala wamba.

Mphamvu ya Timoanaleptic (antidepressant) imaphatikizidwa ndi kutchulidwa kosokoneza, hypnotic ndi nkhawa (anti-nkhawa) chifukwa cha zochita zolimba za anticholinergic ndi antihistamine. Pakadali pano, amitriptyline amadziwika kuti ndi odalirika kwambiri. gwero? ndi antidepressant wotsika mtengo kwambiri. Kuphatikizidwa pamndandanda wamankhwala olimbikitsidwa ndi World Health Organisation.

Ntchito zamankhwala

Ndi choletsa kuphatikizanso kwa neuronal kukwezedwa kwa mkhalapakati wa monoamines, kuphatikizapo norepinephrine, dopamine, serotonin, etc. sizimayambitsa zoletsa za MAO.

Chofunikira kwambiri cha M-cholinolytic (anticholinergic), antihistamine, ndi alpha-adrenolytic ndizochita. Komabe, amitriptyline sichimakhala chopanda mphamvu chokhacho, cholimbitsa thupi. Mphamvu yotsitsimutsayo imatchulidwa makamaka pamlingo wina wa odwala (wodwala aliyense, nthawi imeneyi ndi payekhapayekha) ndipo mwanjira ina imakhudzana ndi kuwonjezeka kwa metabolite yayikulu yogwira amitriptyline, nortriptyline, ndi kutchulidwa kogwira mtima komanso kopatsa mphamvu, makamaka ndi antidepressant komanso mphamvu yogwira ntchito ya mphamvu yeniyeni. Pamene malire apamwamba a "zenera" lino la mankhwalawa atatha, mphamvu yogwira ya amitriptyline imayambanso kufalikira, ndipo mawonekedwe owoneka (komanso antidepressant) amayamba kufooka. Pa milingo yotsika, pansipa "pang'onopang'ono" panjira yolimbana ndi matenda, osalimbikitsa kapena oletsa kuponderezedwa samawonedwa - osadziwika mwachindunji, osokoneza bongo komanso odana ndi nkhawa.

Mothandizidwa ndi mphamvu ya sedative, hypnotic komanso anti-nkhawa, amitriptyline mkalasi ya tricyclics imakhala yotsika kokha chifukwa cha trimipramine ndi fluoroacisin, ndipo chifukwa cha mphamvu yolimbikitsa ndi psychoenergetic chifukwa imakhala yotsika poyerekeza ndi clomipramine, imipramine ndi tricyclics ya subgrouprorttyrort, griportortort. Ndiye kuti, amitriptyline ali pafupi kwambiri ndi kutha "kopanda" kwa chithunzithunzi cha ma triceclic, koma osati kumapeto kwenikweni kwa mawonekedwe.

Kugwiritsa ntchito kusintha kwa mankhwala |Kutulutsa Fomu

Pali mitundu iwiri yotulutsidwa kwa mankhwalawa - mapiritsi ndi yankho la makina a makolo. Pali mapiritsi okhala ndi mulingo wa 10, 25 ndi 50 mg. 1 ml yankho lili ndi 10 mg ya amitriptyline. Mankhwalawa amaperekedwa pokhapokha ngati mwalandira mankhwala.

Zofanizira zojambula zamtriptyline ndi:

Kuphatikiza apo, palinso mankhwala ena oletsa kuponderezana. Gulu la ma tridclic antidepressants limaphatikizanso imipramine ndi clomipramine. Komabe, zowona, kusankha njira yoyenera yothanirana ndi kukhumudwa ndikofunikira kwa psychotherapist, neurologist kapena neuropathologist, ndipo kudzichiritsa nokha ndikosayenera komanso koopsa pano.

Contraindication

Amitriptyline amatsutsana mu:

mitundu yoopsa ya mtima ndi kulephera kwa impso,
zolakwika zamtima,
matenda oopsa
pachimake kapena subacute mitundu ya myocardial infaration,
kuledzera pachimake ndi mowa, mapiritsi ogona, analgesics ndi psychoactive zinthu.
kutseka-kotsekera glaucoma ,,
atrioventricular block 2 tbsp;
osakwana zaka 6
mukutenga ma inhibitors a MAO.

Pa nthawi yomwe mayi ali ndi pakati, kumwa mankhwalawa kungathe kulembedwa pokhapokha pokhapokha ngati dokotala akuganizira zabwino ndi zoipazo. Monga zikuwonetsera poyesa nyama, mankhwalawa ali ndi mphamvu ya teratogenic. Makanda obadwa kumene azimayi omwe amamwa mankhwalawa panthawi yomwe ali ndi pakati amatha kukhala ndi kuwodzera kwambiri kapena kusamba kwakanthawi. Komanso, mankhwalawa saloledwa pa mkaka wa m'mawere chifukwa amatha kulowa mkaka wa m'mawere. Ana a amayi oyamwitsa omwe amitriptyline amathanso kuvutika ndi kugona.

Mankhwalawa, kuphatikiza, amalekanitsidwa chifukwa cha anthu omwe akuyendetsa magalimoto ndikuchita ntchito yomwe imafuna kupendedwa.

Mankhwala amatchulidwa mosamala mu:

mavuto ndi mtima dongosolo (makamaka, matenda a mtima, arrhythmias, mtima kulephera),
uchidakwa wosatha
Mphumu ya bronchial,
kuchepa kwamatumbo oyendetsa galimoto,
mbiri yotsimikiza
manic-depress psychoses,
mikwingwirima
aimpso ndi kwa chiwindi matenda,
kusungika kwamikodzo komanso chikhodzodzo,
thyrotoxicosis,
khunyu
Prostatic hyperplasia.

Chithandizo cha odwala omwe ali ndi vuto lalikulu la m'maganizo komanso chiopsezo chodzipha ayenera kuchitidwa pokhapokha kuchipatala.

Zotsatira zoyipa

Zovuta zoyipa zomwe zimachitika chifukwa ch kumwa mankhwalawa ndi monga:

kugona kapena kugona,
mutu
chizungulire
thupi lawo siligwirizana (khungu - urticaria, zidzolo kapena kuyabwa, kapena mwadongosolo - anaphylactic mantha, edema ya Quincke),
kupweteka kwam'mimba, nseru, kutsegula m'mimba, kudzimbidwa,
kudumphira mu kuthamanga kwa magazi (nthawi zambiri hypotension, chifukwa cha kupindika kwa alpha),
kukakamiza kugwa poyimirira kapena kusuntha thupi kuchoka pabodza kupita pamalo okhala (orthostatic hypotension),
arrhythmias,
kuchuluka kwachulukidwe ka intraocular.

Mu khunyu, kugwiritsa ntchito amitriptyline mu Mlingo pamwamba pa 150 mg patsiku kungayambitse kuchepa kwa khumbo. Ikagwiritsidwa ntchito mwa ana ndi achinyamata mpaka zaka 24, zimatha kuwonjezera ngozi yakufuna kudzipha. Kugwiritsa ntchito nthawi yayitali kumawonjezera zochitika za caries.

Kuchokera kumbali ya chapakati mantha amathandizanso.

kukomoka
tinnitus
kuchuluka kukwiya
chisokonezo
nkhawa
kuyerekezera
chitukuko cha mania,
kusokonezeka kwa kukumbukira
nkhawa yamagalimoto
kuchuluka kwaukali,
khunyu,
extrapyramidal mavuto
kuchepa kwa chidwi,
zolota.

Zowunikira ndizodziwika kwambiri kwa okalamba ndi odwala omwe ali ndi matenda a Parkinson.

Maonekedwe a khunyu imayamba kudziwonetsa nthawi zambiri mukamamwa mankhwalawa kwambiri, odwala matenda a khunyu kapena odwala omwe ali ndi mbiri ya zoopsa za craniocerebral. Zikatero, kusintha kwa mankhwala kapena kuyendetsa anticonvulsants kumafunika.

Kuchokera pamtima ndi zotheka:

mtima conduction matenda,
kusintha kwakanthawi kwa QT pa ECG (kumafuna kuchepetsa mlingo kapena kuyang'anira nthawi zonse),
tachycardia
palpitations.

Zotsatira zoyipa za anticholinergic kanthu:

kamwa yowuma
ana opukusidwa
kuphwanya malo okhala (masomphenya osalala),
kusungika kwamikodzo
kuledzera kwa anticholinergic,
kutsekeka m'mimba (makamaka mwa okalamba komanso odwala omwe ali ndi chizolowezi chodzimbidwa).

Kuchokera mu dongosolo logaya chakudya ndizothekanso:

kukula kwa chiwindi ndi jaundice,
kutentha kwa mtima
kulakalaka kwambiri (nthawi zambiri mankhwala, m'malo mwake, kumabweretsa kuchepa kwa chikhumbo),

Kuchokera ku endocrine system, zochitika zotsatirazi ndizotheka:

testicular edema,
gynecomastia (kukulitsa bere, mwa akazi ndi amuna),
kuchepa kapena kuchuluka kwa libido,
kusintha kwa potency.

Zotsatira zoyipa sizili pambali:

kutaya tsitsi
stomatitis
Lilime lakuda,
kutupa
zotupa zamitsempha
kugwedezeka kwa dzanja (komwe kumakhudzana ndi kukondoweza kwa beta-adrenergic dongosolo, lopumulitsidwa ndikutenga ma beta-blockers),
kusintha kwa kapangidwe ka magazi (leukopenia, eosinophilia, thrombocytopenia), kusinthasintha kwa glucose m'magazi.

Mukasiya ntchitoyo, zotsatirazi ndizotheka:

mutu
chisangalalo
general malaise
kutsegula m'mimba
nkhawa yamagalimoto
kusakhazikika.

Chifukwa chake, musanachotsere mankhwalawa, kuchepetsa pang'onopang'ono ndikofunikira. Zizindikirozi nthawi zambiri zimakhala zosakhalitsa ndipo sizisonyezo zodalira mankhwala.

Malangizo ogwiritsira ntchito

Mlingo woyambirira m'mapiritsi ndi 25-50 mg (mapiritsi awiri a 25 mg) patsiku. Pankhaniyi, mankhwalawa amatengedwa asanagone. Kenako mlingo umawonjezeka pang'onopang'ono (tsiku ndi tsiku 25 mg) mpaka 150-200 mg. Potere, mlingo wa tsiku ndi tsiku uyenera kugawidwa m'magawo atatu. Kuchuluka kwa mankhwalawa kuyenera kumwedwa usiku.

Mu milandu yofatsa, odwala omwe adamwa mankhwalawa kwa nthawi yoyamba, odwala omwe ali ndi matenda osakhazikika, okalamba kapena unyamata, kukonzekera kwapang'onopang'ono kumalimbikitsidwa (25 mg mu masiku 2-3). Pakukhumudwa koopsa, koopsa, m'malo mwake, muyenera kuyamba mwachangu ndi milingo yayikulu ya tsiku ndi tsiku (100 mg).

Pazipita tsiku lililonse mankhwala othandizira odwala amapita kunja ndi 200 mg, pa chithandizo chamankhwala - 300 mg. Nthawi zina, ndikakhumudwa kwambiri komanso kulekerera bwino mankhwalawa, ndizotheka kuwonjezera mlingo waukulu wa tsiku ndi tsiku mpaka 400-450 g.

Mu bulimia amanosa, kusokonezeka kwa malingaliro, schizophrenia, olemedwa ndi psychosis, kusiya mowa kumayamba ndi mlingo wa 25-100 mg (mapiritsi a 25 mg 25) usiku. Pambuyo pakufika pochiritsa, ndikofunikira kusinthira kwa osachepera othandizira - 10-50 mg patsiku.

Kupewa kwa migraine, kupweteka kwamkono wa neurogenic, zilonda zam'mimba zimafuna Mlingo wa 10-100 mg tsiku lililonse (mlingo umayikidwa ndi dokotala potengera zochitika zina). Komanso, ambiri mwa kumwa amatengedwa usiku.

Mankhwalawa okhumudwitsa ana a zaka 6-12, ndikofunikira kumwa mankhwalawa 10-30 mg patsiku. Kapena mutha kuwerengera muyeso malinga ndi kulemera kwa 1.5 mg / kg.

Ndi usiku ma enursis mwa ana a zaka 6-12, 10 mg ndi mankhwala, nthawi zambiri 20 mg. Ana opitirira zaka 12 - mpaka 50 mg. Mankhwalawa amatengedwa kamodzi usiku.

Kutalika kwa chithandizo kumatengera zinthu zambiri - momwe wodwalayo alili, mtundu wa matenda, ndipo amatha kusiyanasiyana kwa miyezi ingapo mpaka chaka chimodzi.

Ngati vuto la impso, kusinthika kwa mlingo kumafunika. Kusintha kwa magazi kumafunikiranso okalamba.

Popewa zinthu zoyipa zomwe zimachitika, mankhwalawa amayenera kumwedwa atangodya.

Ndi kusiyanitsidwa kwambiri kwa mankhwalawo, matendawo amayamba. Chifukwa chake, tikulimbikitsidwa kuti pang'onopang'ono muchepetse mlingo wa mankhwalawa kumapeto kwa maphunzirowo.

Bongo

Pankhani ya bongo, izi ndizotheka:

stupor
kugona kwambiri
chikomokere
chisangalalo
chisokonezo,
chisokonezo
kusanza
kupuma
tachycardia
kukakamiza kutsika
arrhythmias,
kupuma movutikira.

M`pofunika chapamimba lavage, symptomatic mankhwala. Hemodialysis siyothandiza.

Kuchita zinthu zina

Mankhwalawa sagwirizana ndi mowa. Chifukwa chake, munthawi yamankhwala, ndikofunikira kusiya mowa. Simuyenera kumwa mankhwalawo ndi mankhwala ena othandizira. Kugwiritsa ntchito gulu la kusankha la serotonin reuptake inhibitors okhala ndi antidepressants kungayambitse serotonin syndrome.

Ndizosagwirizana kwathunthu ndi gulu lina la antidepressants - Mao inhibitors. Pogwiritsa ntchito munthawi yomweyo ndi Mao inhibitors, kupweteka kwambiri komanso mavuto ena oopsa amatha kuyamba, omwe nthawi zambiri amatha pakufa kwa wodwalayo. Chifukwa chake, nthawi yayitali pakati pa maphunziro a amitriptyline ndi mao inhibitors iyenera kukhala milungu iwiri.

Ndi munthawi yomweyo makonzedwe a benzodiazepines, kuwongolera kwa zochizira zotsatira kuonedwa. Mukamagwiritsidwa ntchito ndi ma antidepressants, barbiturates, sedative, benzodiazepines, anesthetics, zotsatira zoletsa zamkati zamanjenje zimawonjezeka, zotsatira za hypotensive zimayamba, kupuma kwamatenda kumatha.

Amitriptyline imathandizanso kukhudzika kwamtima wama epinephrine, ephedrine ndi mankhwala ofananawo, chifukwa chake pamakhala chiopsezo cha tachycardia, arrhythmias ndi ochepa hypertension. Chifukwa chake, pochita opaleshoni (anesthetics nthawi zambiri imaphatikizapo epinephrine), dokotala ayenera kudziwitsidwa za wodwala yemwe amamwa mankhwalawa antidepressant kuti athetse mlingo wa mankhwala oletsa ululu.

Kuonjezera kuchiritsa kwa anticholinergic, antihistamines, komwe kumatha kuyambitsa mavuto. Amantadine kumawonjezera anticholinergic kwenikweni.

Mankhwala amachepetsa mphamvu ya alpha-blockers, anticonvulsants ndi antihypertensive mankhwala. Clonidine ndi antihistamines amachulukitsa mphamvu ya chapakati pamitsempha yamagazi, atropine imawonjezera chiopsezo cha kufooka kwamatumbo. Nthawi yomweyo, clonidine ndi methyldopa amachepetsa mphamvu ya hypotensive.

Zosangalatsa, nikotini amachepetsa mphamvu ya mankhwalawa. Cocaine imawonjezera chiopsezo cha arrhythmias. Local adrenomimetics kuwonjezera vasoconstrictor kwenikweni. Kugwiritsa ntchito mahomoni a chithokomiro limodzi ndi mankhwalawa kumawonjezera mphamvu komanso njira zowopsa.

Kufotokozera za malangizo ogwiritsira ntchito amitriptyline

Amitriptyline ndi mankhwala ochokera pagulu la antidepressants atatu. Kuphatikiza pazotsatira zazikuluzikulu, imakhala ndi analgesic kwenikweni, imathandizira pochiza kugona.

Amitriptyline amapangidwa ndi opanga angapo - Veropharm zoweta, ALSI Pharma, komanso akunja - Grindex, Nycomed, pansi pa mayina osiyanasiyana ogulitsa:

Amitriptyline ndi gulu lazachipatala la antidepressants. Makina ake onse ndi: C20H23N.The International Nonpxpetary Name (INN) ndi amitriptyline.

Kutulutsa mafomu ndi kapangidwe kake

Amitriptyline imapezeka m'mitundu iwiri - mapiritsi ndi yankho.

Mapiritsi a 10 ndi 25 mg pa ntchito zamkati. Zidutswa 50 ndi 100 zimayikidwa m'matumba a contour.
Njira yothetsera 10 mg / ml, ma ampoules a 2 ml a mtsempha wa magazi ndi mtsempha. Mu phukusi la zidutswa 10.

Mapiritsiwo ali ndi 10 kapena 25 mg yogwira ntchito - amitriptyline hydrochloride. Zinthu zowonjezera (zosagwira) ndi microcrystalline cellulose, talc, lactose monohydrate, silicon dioxide, magnesium stearate, pregelatinized starch.

Kupanga kwa mankhwala "Amitriptyline" mu mawonekedwe a yankho kumaphatikizapo 10 mg yogwira ntchito ndipo kuwonjezera - hydrochloric (hydrochloric) acid, benzetonium ndi sodium chloride, dextrose monohydrate, madzi a kulowetsedwa.

Zotsatira za pharmacological

Mankhwalawa ndi a antidepressants amphamvu. Limagwirira a zochita za amitriptyline pa thupi ndi kuchuluka kwa norepinephrine mu synapses ndi serotonin mu mantha dongosolo (mayendedwe awo amachepetsa). Ndi chithandizo chakanthawi, ntchito ya beta-2 adrenergic komanso ma serotonin receptors mu ubongo amachepa. Ili ndi anticholinergic zotsatira (pakatikati ndi potumphukira).

Kodi amitriptyline amagwira ntchito bwanji mu kukhumudwa? - Amasintha bwino, amachepetsa kukhumudwa, nkhawa, kugona. Mphamvu yothetsa chidwi ya mankhwalawa imadziwonekera patatha masabata awiri itatha kuyambika kwa makonzedwe.

Kuphatikiza pa kutchulidwa kwa antidepressant, mankhwalawa ali ndi zochita zina zingapo.

Antiulcer omwe amagwirizanitsidwa ndi kutsekereza kwa histamine receptors m'mimba.
Anachepetsa chilako.
Kuwonjezeka kwa kuthekera kwa chikhodzodzo kutulutsa ndi kuwonjezeka kwa kamvekedwe ka sphincter, kutengera kuchepa kwa ntchito ya serotonin ndi acetylcholine receptors.
Ngati mankhwala opaleshoni wamba akukonzekera, ndiye kuti ndikofunikira kuchenjeza adokotala kuti amwe mankhwalawa, chifukwa amachepetsa kuthamanga kwa magazi ndi kutentha kwa thupi.
Amachotsa zowawa. Kodi amitriptyline amayamba liti kuthandizira kupweteka? - malinga ndi ndemanga za odwala, kale pamasiku 2-3 a chithandizo.
Zimathetsa kugona.

Zizindikiro zogwiritsidwa ntchito

Mndandanda wazidziwitso ndiwowonjezereka, koma chifukwa chachikulu chokhazikitsidwa ndi amitriptyline ndi mikhalidwe yomvetsa chisoni yamavuto osiyanasiyana.

Kodi chimathandiza amitriptyline ndi chiyani?

Matenda a kukhumudwa - amiseche, amkati, aubongo, otha ntchito, mankhwala, motsutsana ndi maziko akumwa mowa, kuwonongeka kwa ubongo. Makamaka zimachitika ndi nkhawa, kusokonezeka kwa tulo.
Zovuta zam'maganizo zosakanikirana. Amitriptyline itha kutumizidwa kuti aziwopseza.
Psychoses pamsika wa schizophrenia, kusiya mowa.
Matenda owongolera (kusintha kwa chidwi ndi ntchito).
Enursis usiku.
Matenda opweteka kwambiri - pa oncological, matenda amitsempha, postherpetic neuralgia, ululu wammbuyo wammbuyo.
Bulimia amanosa.
Kupewa kwa Migraine
Zilonda zam'mimba zam'mimba.

Zizindikiro zakugwiritsa ntchito mapiritsi ndi Amitriptyline yankho ndizofanana.

Kugwiritsa ntchito mapiritsi

Kodi muyenera kumwa amitriptyline musanadye kapena mutamaliza kudya? Mapiritsi amatengedwa mutatha kudya, osafuna kutafuna isanakwane, kuti muchepetse mkwiyo pamimba.

Mlingo wotsatira woperekedwa ukusonyezedwa mu malangizo ogwiritsira ntchito mapiritsi amitriptyline.

Chithandizo cha mavuto. Mlingo woyambirira ndi 25-50 mg usiku. Kenako onjezani pang'onopang'ono, masiku opitilira 200 mpaka 200 mg patsiku, mugawo 3miyeso. Ngati achire zotsatira zake sizichitika mkati mwa masabata awiri, mlingo wa tsiku ndi tsiku umachulukitsidwa mpaka momwe mungathere - 300 mg.
Chithandizo cha kupweteka mutu, mutu waching'alang'ala, kupweteka kwachangu. Mankhwala othandizira ndi 12,5-100 mg tsiku lililonse, pafupifupi 25 mg. Momwe mungatengere amitriptyline pamutu wamitundu ndi mitundu ina ya ululu? - kamodzi, usiku.
Mlingo wa mapiritsi a Amitriptyline m'malo ena amasankhidwa payekha.

Momwe mungatengere amitriptyline usiku ndi kusowa tulo? Ngati pali chisokonezo cha kugona chotsutsana ndi maziko a kukhumudwa, ndiye kuti izi sizikufuna kusintha kwa chiwembu chokhazikika, mankhwalawa amatengedwa monga tafotokozera pamwambapa.

Mimba komanso kuyamwa

Mankhwala ndi a gulu la C lochita mwana wosabadwayo malinga ndi gulu la FDA (mu maphunziro a nyama, zotsatira zoyipa zapezeka). Chifukwa chake, kuperekedwa kwa amitriptyline panthawi yoyembekezera ndikosayenera kwambiri. Amagwiritsidwa ntchito pokhapokha ngati phindu lomwe limakonzekera mayiyo lipitilira chiwopsezo kwa mwana wosabadwayo.

Mankhwala akaperekedwa pa mkaka wa m`mawere, ndiye njira yonse ya mankhwalawa ayenera kusiya kuyamwitsa.

Gwiritsani ntchito paubwana

Amitriptyline amalembera ana kuti azichiritsa matenda:

mapiritsi - kuyambira wazaka zisanu ndi chimodzi,
yankho - kuyambira khumi ndi awiri.

Sichimaliza kawirikawiri paubwana pochiza matenda okhumudwa. Potere, mlingo, pafupipafupi komanso nthawi yayitali ya chithandizo amasankhidwa payekha.

Kodi amitriptyline amatengedwa bwanji mwa ana omwe ali ndi nkhawa? - mlingo monga:

pa zaka 6 mpaka 12 - 10-30 mg patsiku kapena 1-5 mg / kg,
achinyamata kuyambira azaka 12 - mpaka 100 mg.

Ndi usiku ma enursis:

ana kuyambira zaka 6 mpaka 10 mg wa 10-20 mg pausiku,
achinyamata wazaka 11-16 - mpaka 50 mg patsiku.

Gwiritsani ntchito mu ukalamba

Mu ukalamba, umapangidwira makamaka pamavuto okhumudwa, a bulimia amanosa, osokonezeka m'maganizo, psychoses motsutsana ndi schizophrenia ndi kudalira mowa.

Kodi kutenga amitriptyline kwa okalamba? Pa mlingo wa 25-100 mg usiku, kamodzi. Mukakwaniritsa zochizira, muchepetseni mlingo mpaka 10-50 mg patsiku.

Zotsatira zoyipa ndi zovuta

Zotsatira zoyipa za amitriptyline zimayamba kupezeka kwambiri ndipo zimatha kutchulidwa kotero kuti zimaposa chithandizo chamankhwala. Pankhani imeneyi, chisankho pa nthawi yoikidwiratu nthawi zonse chimapangidwa mosamala, ndipo odwala ndi mabanja awo ayenera kuwunika momwe alili panthawi ya chithandizo.

Zotsatira zoyipa zogwirizana ndi anticholinergic kanthu:

Kusawona bwino, ana opukutidwa, ziwopsezo za malo okhala, kuchuluka kwa anthu mkati, kukhala ndi mbali yopapatiza ya chipinda chamaso,
kamwa yowuma
chisokonezo,
kudzimbidwa, kufooka matumbo,
kukodza pokodza.

Zotsatira zoyipa za mtima wamanjenje:

kukomoka
kugona
kutopa kwambiri
kusakhazikika
kusokonezeka kwa kukumbukira
kusanja m'mlengalenga,
kuda nkhawa, kuda nkhawa,
kuyerekezera zinthu zakale (nthawi zambiri okalamba ndi omwe ali ndi matenda a Parkinson),
Psychotor
mania, komanso hypomania,
kuchepa kwa chidwi,
zosokoneza tulo
zolota
asthenia
pali mutu, kugwedezeka, kukoka kowonjezereka, dysarthria, paresthesia, myasthenia gravis, ataxia, extrapyramidal syndrome.

Kwa mtima:

tachycardia
arrhasmia,
orthostatic hypotension,
Kusintha kwa ECG kwa odwala omwe alibe matenda a mtima,
kudumphira m'magazi,
kuphwanya intraventricular conduction.

Kuchokera m'mimba:

kutentha kwa mtima
nseru
kupweteka m'mimba
kusanza
chiwindi
kulakalaka
kunenepa kwambiri kapena kuchepa thupi,
kusintha kwa kukoma
stomatitis
kutsegula m'mimba
kudetsa lilime.

Kuchokera ku endocrine system:

testicular edema
Kuchulukitsa kwa anthu m'mawere,
kuchepa kapena kuchuluka kwa libido,
mavuto a potency
kuchuluka kapena kuchepa kwa shuga m'magazi,
kuchepa kwa vasopressin.

kuyabwa
zotupa pakhungu, urticaria,
angioedema (Quincke),
zithunzi.

Zotsatira zina zoyipa:

tinnitus
kutaya tsitsi
edema
malungo
zotupa zamitsempha
kusungika kwamikodzo.

Malangizo apadera

Chitani zinthu mosamala mosamala ndikusintha chiopsezo chokhala ndi mavuto.

Zimatsimikiziridwa kuti mu ana, achinyamata komanso anthu osakwana zaka 24 omwe akuvutika ndi kupsinjika ndi malingaliro, mankhwalawa amawonjezera mawonekedwe a malingaliro odzipha komanso chikhalidwe. Chifukwa chake, kusankhidwa kwa amitriptyline m'gulu lino la odwala kuyenera kukhala koyenera!
Odwala okalamba, chithandizo chimatha kuyambitsa kupangika kwa psychosis ya mankhwala usiku. Pambuyo pakutha kwa mankhwalawa, matendawa amakhazikika masiku angapo.
Odwala omwe ali ndi vuto la kuthamanga kwa magazi, zizindikirozi ziyenera kuyang'aniridwa nthawi yonse ya chithandizo. Zitha kuchepa kapena kuchuluka kwambiri.
Ndikulimbikitsidwa kupewa kuyendayenda mwadzidzidzi - kusunthira mosunthika kumbali yopingasa, monga chizungulire komanso kusowa kozungulira kungachitike.
Kugwiritsa ntchito mowa ndi mankhwala okhala ndi ethanol ndizoletsedwa panthawi yonse ya chithandizo!
Ngati chithandizo ndi Mao zoletsa chikuchitika, amitriptyline ndi mankhwala palibe kale kuposa masiku 14 atachotsedwa.
Mlingo woposa 150 mg patsiku umachepetsa mphamvu yolumikizira zinthu ndipo umawonjezera chiopsezo cha kugwidwa ndi anthu omwe ali ndi vuto la khunyu.
Ndi nkhawa yayikulu, chiopsezo chodzipha chimakhala chokwanira nthawi zonse, chifukwa chake, kumayambiriro kwa chithandizo, makonzedwe ofanana a benzodiazepines kapena antipsychotic akulimbikitsidwa.
Odwala omwe ali ndi vuto la cyclic, zovuta za manic ndi hypomanic zimatha kupezeka nthawi ya mankhwala ndi amitriptyline. Zikatero, sinthani mlingo kapena mankhwalawo.
Odwala omwe ali ndi chithokomiro, komanso omwe amalandila mahomoni a chithokomiro, zotsatira za mtima.
Kuphatikiza ndi chithandizo cha electroconvulsive, mankhwalawa amatha kugwiritsidwa ntchito moyang'aniridwa ndi achipatala.
Odwala omwe amagona pakama amakhala kuti ali ndi matenda opuwala m'mimba.
Ngati pali opaleshoni wamba, muyenera kuuza dokotala za kumwa mankhwala amitriptyline.
Mwina kuchepa kwamadzi yachilendo komanso kuwonjezeka kwa ntchofu mu magazi. Kwa magalasi olumikizana, izi zitha kuwononga corneal epithelium.
Anthu omwe amatenga amitriptyline kwa nthawi yayitali amakhala ndi chiopsezo chowonjezereka cha caries.
Chisamaliro chikuyenera kuchitika mukamachita zinthu zoopsa zomwe zimafuna chisamaliro ndi kuthamanga kwa mayankho. Mukamayendetsa galimoto, kutenga amitriptyline sikulimbikitsidwa.

Kutengera ndi zomwe zingachitike, magulu awa a anthu agwiritse ntchito mankhwalawa mosamala kwambiri:

zidakwa
ana ndi achinyamata osakwana zaka 14,
odwala okalamba
matenda monga schizophrenia, bronchial mphumu, kupuma kwa magazi, khunyu, kufooka kwa mafupa hematopoiesis, mtima ndi mtima, matenda amitsempha, sitiroko, kuchepa kwa magalimoto ntchito yam'mimba ndi matumbo, chiwindi, kulephera kwa impso, chithokomiro, chikhodzodzo hypotension.

Kudalira kwa Amitriptyline

Mankhwalawa siungule mankhwala osokoneza bongo, popeza alibe mankhwala oledzera kapena oledzera, samayambitsa chizolowezi chomwa thupi, monga opiates. Kudalira amitriptyline kumangokhala zamaganizidwe, zomwe sizikugwirizana ndi kufunitsitsa kwa mankhwalawa. Kuti mumvetsetse momwe mungakhalire osokoneza bongo, muyenera kudziwa tanthauzo la zomwe mankhwalawa amagwira - ma neurotransmitters achilengedwe samawola m'thupi mwachisawawa, motero sasintha kwa nthawi yayitali. Zomwe zimachitika potenga amitriptyline zimatheka ndikusungabe nthawi yayitali ya serotonin ndi ma neurotransmitters ambiri.

Kodi amitriptyline ndiwosokoneza? Monga antidepressants onse, imatha kupanga kudalira kwinakwake - mwadzidzidzi kuleka, zizindikiro zimabwereranso. Mwanjira imeneyi ndi pomwe amitriptyline amawaganizira kuti ndi mankhwala, popeza mankhwalawo akumwa, munthu amakhala bwino, ndipo maphunzirowo atamalizidwa, matendawo amabwerera. Zimachitika kuti odwala amasintha kuchokera ku mankhwala othandizira kupanikizika kukhala mankhwala enieni. Chifukwa chake, pofuna kupatula vuto lomwe lingakhalepo kuchokera ku amitriptyline, phwando lake limathetsedwa pang'onopang'ono, mwezi umodzi.

Kuletsa matenda

Ndi kukana kwakukulu kwa mankhwalawo, makamaka ngati adamwa kwambiri, ndizotheka kuti chitukuko cha amitriptyline achire matenda. Zizindikiro zake ndi ziti?

nseru
kusanza
mutu
kutsegula m'mimba
zosokoneza tulo
malaise
zolota.

Ngakhale ndi kulephera kwapang'onopang'ono, nkhawa zamagalimoto, kusakwiya, kusokonezeka kwa tulo, kukulitsa maloto akulu.

Kodi kuchoka kwa amitriptyline kumatenga nthawi yayitali bwanji? - mawonekedwe amawonedwa pakapita nthawi, mpaka mankhwala atachotsedwa, ndiye kuti, masiku 8-14. Mawonetsedwe owonjezereka ali kale okhudzana mwachilengedwe.

Njira yochepetsera amitriptyline ndi kuchepa pang'onopang'ono mu mankhwala othandizira pakutha kwa mwezi umodzi, kuyambira pa ¼ mpaka atachotsedwa kwathunthu.

Zoyambitsa bongo

Kuchulukitsa kwa mlingo umodzi wa mankhwala nthawi zambiri kumachitika mu milandu iyi:

osagwirizana ndi mlingo womwe dokotala wamulembera (mwadala kapena mwangozi),
kugwiritsa ntchito mankhwalawa popanda mankhwala a dokotala,
kuphatikiza kwa mankhwalawa pachithandizo chowonjezera cha zakumwa zoledzeretsa.

Zizindikiro zosokoneza bongo

Kutengera kuchuluka kwa amitriptyline omwe atengedwa, madigiri atatu a mankhwala osokoneza bongo amawerengedwa - ofatsa, odziletsa komanso okhwima, omwe popanda njira zotsitsimutsa amatha ku 100% ya milandu.

Ana amakonda kwambiri bongo, ngakhale kupha.

Mankhwala ochepetsa bongo a amitriptyline amawonetsedwa ndi izi:

kamwa yowuma
kudzimbidwa
kusowa pokodza
dyspepsia.

Kuwonetsedwa kwa mankhwala osokoneza bongo ochulukirapo komanso ovuta kwambiri nthawi zonse kumakhala koopsa ndipo kumafunikira kuchipatala msanga.

Kuchokera kumbali ya dongosolo lamkati lamanjenje - kuwodzera kugona, kuyerekezera zinthu m'maganizo, kuda nkhawa, khunyu, kuwonjezereka, kusalankhula bwino, kutsekeka kwa minofu, chisokonezo, kutaya mtima m'malo, kuchepa ndende, kupsinjika kwa psychomotor, ataxia, stupor, chikomokere.
Kuchokera kumbali ya mtima ndi mitsempha yamagazi - arrhythmia, tachycardia, kuphwanya kwa intracardiac conduction, kulephera kwa mtima, kuchepa kwakukulu kwa kuthamanga kwa magazi, kugwedezeka, kumangidwa kwa mtima (osowa).
Mawonetsedwe ena ndikuchepa kwa kuchuluka kwa mkodzo, mpaka kusakhalapo kwathunthu, matenda oopsa, kuchuluka thukuta, kusanza, kufupika, kupuma, cyanosis, impso ndi chiwindi.
Pamalo omaliza, kuthamanga kwa magazi kumatsika, ophunzirawo samayankha kuwala, kuzimiririka kuzimiririka, chiwindi, kulephera kwa mtima, komanso kumangidwa kwamapapo.

Mlingo wowopsa ndi magalamu 1.5 amitriptyline omwe amamwa nthawi imodzi. Komabe, zochepa ndizokwanira ana.

Chithandizo cha poizoni

Pazizindikiro zoyambirira za mankhwala osokoneza bongo, ndikofunikira kuchita zotsatirazi asanachitike mankhwala.

Imbani ambulansi.
Apatseni wodwalayo madzi okwanira lita imodzi ndi kuyamba kusanza. Bwerezaninso njirayi mpaka madzi oyera osamba atulukire.
Tengani ma enterosorbents kuti muchepetse kuyamwa kwa magazi m'magazi - Enterosgel, kaboni yokhazikitsidwa, Atoxil, MP wa Polysorb ndi ena.
Ngati munthu wasowa chikumbumtima, ayenera kutembenukira kumbali imodzi.

Kuchiza poyizoni wa amitriptyline kumachitika mosamala kwambiri ndipo kumakhala ndi njira zotsatirazi zochizira.

Zadzidzidzi chapamimba.
Kukhazikitsidwa kwa njira zothetsera mchere kuti muchepetse kuthamanga kwa magazi, acidosis yolondola, usawa wamagetsi wamadzi.
Kutenga cholinesterase inhibitors kuti muchepetse mawonekedwe a anticholinergic.
Kukhazikitsidwa kwa glucocorticoids ndi kutsika kwakuthwa m'magazi.
Kupereka mankhwala othandizira mtima.
Kuyang'anira odwala kwa maola 24 ndi kuwunika kuthamanga kwa magazi ndi kugunda kwa mtima.
Woopsa milandu - kukonzanso, anticonvulsant miyeso, magazi.

Hemodialysis ndi okakamiza diuresis sanawonetse kuti amagwira ntchito mopitirira muyeso ndi amitriptyline.

Palibe mankhwala enieni a poizoni wa amitriptyline.

Zotsatira za poyizoni

Mankhwala osokoneza bongo owopsa amapha, ngakhale atalandira chithandizo chamankhwala panthawi yake. Choyambitsa imfa ndi kumangidwa kwamtima, kupuma, mtima kwambiri.

Zotsatira za bongo wa amitriptyline zimakhalabe, ngakhale munthu atha kupulumuka:

Kusintha kwa malingaliro, kukhumudwa kwambiri,
Matenda aimpso ndi a hepatic,
kusokonezeka kwa mtima.

Zotsalira zotsalira zimadziwika m'moyo wonse ndipo zimafuna mankhwala osokoneza bongo nthawi zonse.

Analogue yoyeserera ya amitriptyline ndi mankhwala omwe amachokera ku Spain a Saroten Retard, omwe amapangidwa ndi H. LUNDBECK A / S (Denmark).

Ndi chiani china chomwe chitha kusintha m'malo mwa amitriptyline? Zofananira zamagulu ndi Anafranil, Doxepin, Melipramin, Novo-Tryptin - mankhwalawa ali ndi zotsatira zofanana, koma amasiyana mosiyanasiyana. Mankhwalawa ndi fanizo lamakono la amitriptyline popanda zotsatira zoyipa za antidepressant.

Kuchita ndi mankhwala ena

Musanayambe chithandizo ndi amitriptyline, muyenera kuuza dokotala za mankhwala onse omwe amamwa mosalekeza.

Sizingaphatikizidwe ndi MaO inhibitors.
Amitriptyline imawonjezera mphamvu ya inhibitory ku ubongo wa sedative, hypnotics, analgesics, mankhwala opaleshoni, antipsychotic ndi mankhwala a ethanol.
Kuchepetsa mphamvu ya anticonvulsants.
Itha kuyikidwa pamodzi ndi mapiritsi ogona (mwachitsanzo, "Sonapax" amatengedwa ndi amitriptyline). Koma kuphatikiza uku, kumawonjezera ntchito ya anticholinergic ya Sonapax - ndiko kuti, kumachepetsa kuthekera kwa maselo aubongo kupatsira ziwalo zamitsempha.
Kuphatikiza ndi ma antidepressants ena, zomwe zimapangitsa kuti mankhwalawa onse azikhala ndi mphamvu.
Akaphatikizidwa ndi antipsychotic ndi anticholinergic mankhwala, kutentha kwa thupi kumatha kuwonjezeka komanso kutsekeka kwamatumbo kumayamba.
Amitriptyline imapititsa patsogolo zotsatira zamphamvu za catecholamines ndi adrenostimulants, ndikuchulukitsa chiopsezo cha tachycardia, mtima arrhythmias, komanso matenda ochepa owopsa.
Machepetsa mphamvu ya antihypertensive ya guanethidine ndi mankhwala ofanana.
Kuphatikiza ndi zotumphukira za coumarin kapena indandion, zochitika za anticoagulant zotsirizira zimatha kukula.
Kuphatikizanso ndi cimetidine, ndende ya amitriptyline mu plasma yamagazi imachulukanso, zomwe zimawonjezera mwayi wa poizoni.
Amatsogolera microsomal chiwindi michere (carbamazepine ndi zina barbiturates) amachepetsa ndende ya amitriptyline.
Quinidine amachepetsa kagayidwe ka amitriptyline.
Ma mahomoni okhala ndi estrogen amachulukitsa bioavailability wa amitriptyline.
Kuphatikiza ndi disulfiram ndi acetaldehyde dehydrogenase inhibitors, delirium imatha kupanga.
Amitriptyline imatha kupititsa patsogolo kukhumudwa, komwe kunawoneka kumbuyo kwa glucocorticoids.
Kuphatikiza ndi mankhwala ochizira matenda a thyrotoxicosis, mwayi wokhala ndi agranulocytosis ukuwonjezeka.
Kuphatikiza kwa nootropics kumayambitsa kufooka kwa zochita za mankhwalawa ndikuwonjezera mwayi wazotsatira zoyipa.
Kusamala kuyenera kuphatikizidwa ndi digitis ndi baclofen.
Kuyanjana bwino kwa amitriptyline ndi maantibayotiki, ma antiviral mankhwala (i.e. Acyclovir). Itha kuphatikizidwa momwe adayang'aniridwa ndi dokotala.

Mafunso Ofunsidwa Kawirikawiri

Tikuyankha mafunso odziwika omwe aphatikizidwa pamaziko a mafunso ofunikira okhudzana ndi mawonekedwe ogwiritsira ntchito amitriptyline komanso kuphatikiza kwake ndi mankhwala ena osafotokozedwa pamayendedwe ovomerezeka.

Kodi mankhwala amitriptyline kapena ayi? Migwirizano yogulitsa m'mafakitale - kokha mwa mankhwala.
Kuphatikiza kwa amitriptyline ndi donormil, kodi mankhwalawa angaphatikizidwe? Kuphatikiza kumeneku kumachitidwa ndi madokotala - amitriptyline adzathandizira Donormil. Koma mankhwalawa amatengedwa nthawi zosiyanasiyana patsiku ndipo mosamalitsa kuchipatala moyang'aniridwa ndi dokotala.
Kodi amitriptyline ndi phenibut ndi chiyani? Popeza "Phenibut" amatanthauza nootropics, kuphatikiza ndi amitriptyline, mphamvu yothandizanso ya mankhwalawa imachepetsedwa, ndipo mwayi wazotsatira zimakulanso. Kuphatikiza uku kuyenera kukambirana ndi dokotala.
Kodi amitriptyline imagwirizana ndi corvalol? Mankhwalawa saletsa, koma Corvalol ili ndi phenobarbital, yomwe imatha kupititsa patsogolo zotsatira za amitriptyline.
Kodi carbamazepine (Zeptol, Carbalepsin Retard, Tegretol, Finlepsin) imagwirizana ndi amitriptyline? Mankhwala amatha kuyikidwa limodzi, koma muyenera kukumbukira kuti, mwina, kuwonjezeka kwa mphamvu ya chapakati pamitsempha yamafupa, kuchepa kwa mphamvu ya anticonvulsant ya carbamazepine ndi kuchepa kwa kuchuluka kwa amitriptyline m'magazi.
Kodi amitriptyline ingatengedwe ndi phenazepam? Mankhwalawa amatha kuikidwa limodzi panjira yochepa pokhapokha, kuti tifulumizitse mpumulo wazizindikiro komanso kuchepetsa zovuta za antidepressant.
Kodi amitriptyline ndi cinnarizine zikugwirizana? Kulembera ndikotheka, koma kuyang'aniridwa ndi dokotala, chifukwa kuphatikiza uku kumapangitsa kuti mankhwala oletsa kupanikizika azikhala othandiza.
Kuphatikiza kwa fluoxetine ndi amitriptyline, kungaphatikizidwe? Fluoxetine ndiwothandizanso kuthana ndi vuto, koma kuchokera pagulu lina ndipo ali ndi njira yabwino yogwirira ntchito. Kuphatikizikako ndi kotheka kugwiritsa ntchito mankhwala ochepetsa mphamvu ya mankhwalawa komanso monga adokotala adalembera, koma ndizowopsa pakupanga zotsatira zoyipa.
Kodi Velafax ikugwirizana ndi amitriptyline? Ndiwothandizanso kuponderezana, makina ochitachita omwe ali osiyana. Kuphatikizika kwawo ndikotheka, koma mankhwalawa amagawidwa pakanthawi - "Velafax" m'mawa, ndi amitriptyline madzulo muyezo wotsikirapo ndipo amayang'ananso momwe thupi limagwirira ntchito kuti athe kupatula zovuta zomwe zimapangitsa kuti mantha azikhala pakati.
Kodi amitriptyline imagwirizana ndi piracetam? Ma nootropics saloledwa kuti aphatikizidwe ndi antidepressants chifukwa cha kusiyana kwawo pochita - zolimbikitsa motsitsimutsa. Kugwiritsa ntchito bwino kwa mankhwalawa kumatha kuchepa ndipo chiwopsezo cha zotsatira zoyipa chikhoza kuchuluka. Ngati kuphatikiza koteroko kumayikidwa ndi dokotala, ndiye kuti ndibwino kugawanitsa kudya mapiritsi nthawi ndi nthawi.
Kodi nditha kumwa amitriptyline ndi Paxil nthawi imodzi? Awa ndi ma antiidepressant awiri ochokera m'magulu osiyanasiyana. Kuphatikiza kotereku kumagwiritsidwa ntchito, koma sikungatengedwe pakokha, popeza pamakhala chiopsezo chowonjezera zotsatira za zonse ziwiri.
Kodi amitriptyline ndi Eglonil ndikugwirizana kwanji? Awa ndi antipsychotic omwe ali ndi zotsatira za antipsychotic, chifukwa chake tikamagwiritsidwa ntchito palimodzi, pamakhala chiwopsezo chowonjezeka chowonjezera cha mtima. Ngati kuphatikiza koteroko kumachitidwa, ndiye kuti mankhwalawo amalembedwa nthawi zosiyanasiyana.
Kodi nditha kutenga escitalopram ndi amitriptyline? Kuphatikiza kwa ma antidepressant awiri sikuti nthawi zonse koyenera. Nthawi zina kuphatikiza uku kumachitika mu kupsinjika kwakukuru, koma chothandizira kwambiri chamankhwala chimayamba ndi kuphatikiza kwa antidepressant ndi tranquilizer.
Kodi ndingatenge Afobazole ndi amitriptyline palimodzi? Mankhwalawa amagwira ntchito chifukwa Afobazol amatanthauza ma tranquilizer ndipo nthawi zambiri amawayikidwa limodzi ndi antidepressants. Koma motsutsana ndi maziko amitriptyline yamphamvu, mphamvu za Afobazole zitha kutayika, chifukwa chake, ndi dokotala yekha amene angasankhe chithandizo cha mankhwala.
Kodi amitriptyline ndi Atarax atha kukhala limodzi? Ichi ndi mankhwala ochokera pagulu la anthu amtendere, motero ayenera kuphatikizidwa ndi amitriptyline m'maiko achisoni. Koma kulandira kwawo panthawi zosiyanasiyana kumafunika.
Kodi pali mankhwala omwe angagulidwe pa counter ndi amitriptyline? Pali mankhwala osapepuka omwe amalembedwa, zomwe zimatheka chifukwa cha mankhwala ochepetsa nkhawa - Persen, Novo-Passit, Deprim, Azafen ndi ena. Koma kugulitsa mankhwala osagwiritsa ntchito mankhwala sikutanthauza kuti mutha kudzipatsanso mankhwala!
Kodi amitriptyline ndi Finlepsin angatengedwe pamodzi? Mankhwalawa amagwiritsidwa ntchito pochiza khunyu, komanso neuralgia ndi kupweteka, kotero mwina akuwonjezera kuchuluka kwa inhibitory kwa chapakati mantha dongosolo la amitriptyline kapena kuchepetsa kugwiritsidwa ntchito kwake m'magazi.
Kodi amitriptyline ingatengedwe ngati mapiritsi ogona? Ngati kusowa tulo sikumakhudzana ndi kukhumudwa, mankhwalawa sawonetsedwa.
Ngati amitriptyline nthawi zambiri amatengedwa, zotsatira zake ndi chiyani? Chithandizo chanthawi yayitali nthawi zonse chimagwirizanitsidwa ndi chiopsezo chachikulu cha mavuto. Chithandizo cha mankhwala choopsa chotere chikuyenera kuchitika pokhapokha kuyang'aniridwa ndi adokotala komanso Mlingo wokwanira.
Kodi amitriptyline angaperekedwe kwa munthu woledzera? Ayi, ndizosagwirizana ndi mowa!
Kodi amitriptyline imakhala ndi zochulukirapo kapena ayi? Inde, kuchiritsika kwa mankhwalawa ndikopindulitsa ndipo kumachitika kwathunthu patatha sabata ziwiri.
Chifukwa chiyani akuyamba mafuta kuchokera ku amitriptyline? Chimodzi mwazotsatira zake ndi kuchuluka kwa chidwi cha kudya. Nthawi zina izi zimabweretsa kulemera.
Kodi amitriptyline amawonjezera kapena amachepetsa kuthamanga kwa magazi? Mankhwala amatha kuchepetsa ndikuwonjezera. Kudumpha kuzizindikiro kumatha kuonedwa tsiku lonse.
Kodi mungachotse bwanji kufooka mutatha kutenga amitriptyline? Kusuta kwa mankhwalawa kumatha masiku 7-14. Ngati vutolo silikuyenda bwino, muyenera kuwunikiranso mankhwalawo kapena kusintha mankhwalawo ndi ena.
Kodi amitriptyline amagwira ntchito mpaka liti? Mankhwala othandizira amalowa m'magazi mkati mwa mphindi 30 pambuyo pakulowetsedwa ndipo amakhalapo kwa pafupifupi maola 7-10 (maola 28 apamwamba). Pafupifupi kuchuluka kovomerezeka kwa mtundu umodzi wa mankhwalawo.
Pambuyo kuti amitriptyline amachotsedwa mu thupi liti? Kuchotsa kwathunthu kumachitika masiku 7-14 kutatha kulandila.
Ndi dokotala uti omwe amandiwonetsa amitriptyline? - wazamisala.
Ndingatenge nthawi yayitali bwanji osapumira? Njira ya chithandizo ndi miyezi isanu ndi itatu.

Amitriptyline - mankhwala amphamvu ogwirizana ndi antidepressants a m'badwo "wakale". Zotsatira zake zoyipa nthawi zina zimaposa zabwino zamankhwala. Chifukwa chake, lingaliro lozitenga liyenera kupangidwa kokha ndi dokotala. Kudzipangira nokha mankhwala ngati amenewa kumakhala pachiopsezo cha moyo!

Kuphatikizika ndi katundu

Mankhwalawa amadziwika muzochita zamankhwala monga mankhwala othandizira. Ndi njira yamtundu wamatumbo atatu, ndipo ilinso ndi machitidwe awa:

ngati wothandizila pakuyambira wapakati,
Monga njira yochepetsera chilimbikitso ndi kuthetsa milandu ya matenda a mkodzo, wothandizira wokhala ndi mawonekedwe a antiserotonin,
akulimbikitsidwa kuti mugwiritse ntchito bulimia amanosa.

Amapezeka mu mawonekedwe a mapiritsi kapena yankho. Nthawi zambiri, piritsi limagwiritsidwa ntchito pochiza. Mtundu ukhoza kukhala woyera kapena wachikasu. Kutulutsidwa mawonekedwe - lathyathyathya.

Pali chamfer pamapiritsi, omwe amawonetsetsa kuti mulingo woyenera umaperekedwa ndi dokotala pofotokoza amitriptyline. Malangizo atsatanetsatane ogwiritsira ntchito amitriptyline pamapiritsi amayikidwa mu bokosi la makatoni.

Izi ndizosangalatsa! Chifukwa chiyani diazepam imalembedwa: malangizo ogwiritsira ntchito (antide)

Mukapereka mankhwala, dokotala adzakuwuzani mwatsatanetsatane za amitriptyline: zomwe zimathandiza, momwe mungazitengere molondola.

Chowoneka mosiyana ndi kuphatikizika kwapakati komanso pakati pa anticholinergic kanthu, mphamvu sedation.

Mukamatenga, pali kuwonjezeka kwa kuchuluka kwa serotonin ndi norepinephrine pakati pamitsempha yamagazi, komanso njira yochepetsera kuchuluka kwawo kwa mayamwidwe.

Mukamagwiritsa ntchito

Chifukwa chachikulu chotsimikizika choikidwacho chimawerengedwa kuti chimapezeka ndikumva kupsinjika, komwe kumayendetsedwa ndi:

kugona kusokonezedwa
kusowa tulo
nkhawa zochulukirapo,
chipwirikiti
mawonetseredwe ena amayiko okhumudwitsa, kuphatikiza pa odwala adakali aang'ono.

Amawerengera matenda otsatirawa:

pa nthawi yodziwitsa schizophrenia,
pakuwona chizindikiro chodzilekera,
pakakhala usiku ma enursis, koma palibe chikhodzodzo,
pa milandu yodwala ululu, kuphatikizira omwe amayamba chifukwa cha khansa.
ululu wammbuyo ukawonedwa,
ndi neuropathy ya pambuyo pake.

Ma antrepressant amitriptyline atha kulembedwa ndi mutu wowopsa ndikulimbikitsidwa kwa odwala omwe ali ndi zilonda zam'mimba.

EMphamvu yothana ndi mavuto a dziko lapansi imawonekera patatha milungu itatu.

Chipilala

Makampani ogulitsa mankhwala amapereka mitundu iwiri ya kutulutsidwa: yankho ndi mapiritsi. Nthawi zambiri, mapiritsi amaperekedwa pambuyo chakudya.

Izi ndizosangalatsa! Momwe mungatenge kuchokera pa zomwe mungatenge Asafen: Zizindikiro zogwiritsidwa ntchito

Amatha kukhumudwitsa makoma am'mimba, chifukwa chake sikulimbikitsidwa kutafuna. Mukamamwa ndi madzi.

Mu magawo oyamba azithandizo, mlingo wa 25-50 mg umagwiritsidwa ntchito. Mlingo tikulimbikitsidwa kuti atenge usiku. Zalandiridwa mkati mwa masiku asanu Kuchuluka kwa milingo kumachitika mpaka 200 mg patsiku.

Ndalamazi zimagawidwa m'magawo atatu mukatha kadzutsa, nkhomaliro komanso chakudya chamadzulo. Ngati palibe zoyenera pambuyo pa milungu iwiri yoyendetsa, mankhwalawa akhoza kuchuluka mpaka 300 mg.

Posankha yankho, imayendetsedwa mu intramuscularly pa 20-40 mg pa jakisoni. Jekeseni amapangidwa kanayi pa tsiku, pang'onopang'ono kusamutsa wodwala kuti agwiritsidwe ntchito ngati mapiritsi.

Ngati mankhwalawa amagwiritsidwa ntchito pochiza ululu, migraine, mlingo umafika mpaka 100 mg patsiku.

Mitundu ya zochita zoyipa

Mankhwalawa ali ndi zovuta zingapo.

Kwa amitriptyline, mawonekedwe otulutsidwa ngati mapiritsi kapena yankho limayendetsedwa ndi malangizo mwatsatanetsatane momwe zimachitika mwanjira imeneyi.

Kuphatikiza pa kutenga kungawonedwe:

Mawonekedwe oyipa a dongosolo lamanjenje, omwe akuphatikizaponso kuchuluka kukondwerera, mawonekedwe a kukomoka komanso kuyerekezera zinthu zina, mawonekedwe a nkhawa zamagalimoto, kuwonjezeka kwa zizindikiro zokhumudwitsa ndi ena.
Pa mbali yamtima wamtima, zotsatira zoyipa zimadziwika ndi arrhythmia, mawonekedwe a kusokonezeka kwa intraventricular conduction, tachycardia, komanso kuwonjezeka kwa pafupipafupi kwamikwingwirima yamtima.
Zokhudza kugaya chakudya zimadziwika, kuphatikizapo kuda khungu, hepatitis, kuwoneka kwa kusintha kwamkatimilandu ya kusanza komanso kutsegula m'mimba.
Zotsatira za anticholinergic zimatha kuwoneka mwanjira yakusawona bwino, kuwonjezeka kwakukulu kwa kukakamira kwa intraocular, tachycardia, delirium. Kusokonezeka kwa chikumbumtima kumadziwika komanso kuchuluka kwa thukuta kumachepa.

Mawonekedwe olakwika amadziwika atatsiriza maphunzirowo kapena kuletsedwa.Kuphatikiza maloto osazolowereka, kutsekula m'mimba ndi mseru, kusowa tulo komanso mutu wokhazikika ungayambe.

Zotsatira zoyipa zikachitika, muyenera kufunsa dokotala kuti musinthe mankhwalawo, chifukwa mankhwalawa monga amitriptyline, zotsatirapo zake zoyipa zingakhale zowopsa paumoyo wa wodwalayo.

Izi ndizosangalatsa! Chifukwa chomwe adaptol imathandizira: malangizo ogwiritsira ntchito

Ngakhale malangizo omwe angagwiritsidwe ntchito a amitriptyline adakwaniritsidwa, ndikofunikira kuyang'anira wodwala pafupipafupi. Zinthu monga contraindication ndi zovuta zingapo zoyipa ziyenera kukumbukiridwa pakukula kwa njira ya chithandizo ndi kusankha kwamankhwala.

Ngati zolakwa zinalengedwa pakudya ndipo bongo wambiri unachitika, zimawonekera ngati ziwonetsero zoipa mbali zonse za thupi. Kuphatikizapo chapakati mantha dongosolo, mtima, m'mimba. Ndi chikhalidwe cha mawonekedwe, ali ofanana ndi zoyambitsa kuvomereza.

Mankhwala osokoneza bongo amadziwika mukagwiritsa ntchito mankhwalawa mapiritsi ndi yankho. Ngati mulingo wa thunthu la mankhwala likupitirira pakugwiritsidwa ntchito pakumwa pakamwa, phokoso lam'mimbamo limachitika. Ndikofunikira kuyimba ambulansi nthawi yomweyo. Asanachitike madotolo, kusinthaku kumachitika mwaokha ndi wodwala ndi abale ake. Kuchita kotereku kumafunika chifukwa cha mndandanda wowopsa wazowonekera, zomwe nthawi zina zimatha kutha ndikumangidwa kwamtima.

Mitu ya mankhwalawa

Chida ichi chili ndi mitundu yambiri. Pazonse, njira zoposa 40 zakumwa zomwe zingaperekedwe.

Kuphatikiza mankhwala: gelarium hypericum, lotonica, dystonicum, azafen, neurol, valdoxane, citron, gerfonal.

Kusankha kwa analogi yamankhwala kumachitika ndi katswiri. Zanga kuletsa kapena kulowa m'malo sikololedwa.

Mankhwalawa ndi omwe amathandizanso kuthetsa nkhawa yayikulu komanso kukhumudwa. Kwa amitriptyline, analogi ndizambiri ndipo amakupatsani mwayi wosankha bwino mankhwala. Mankhwala ofanana ndi omwe amagwiritsidwa ntchito amitriptyline amathandizanso kupereka chithandizo kwa onse omwe amatsatira.

Malangizo Ogwiritsa Ntchito Mwapadera

Ngati kugwiritsa ntchito yankho lafunsidwa, kuyambitsa kumachitika mu chipatala kokha komanso kuyang'aniridwa ndi madokotala mosalekeza. M'masiku oyamba ovomerezeka mwanjira iliyonse, wodwala ayenera mosamalitsa kugona pakama.
Asanatenge, kuchuluka kwa kuthamanga kwa magazi kumayang'aniridwa.
Kuyambira pa ethanol nthawi yonse yoyang'anira iyenera kusiyidwa kwathunthu, kuphatikiza koteroko ndizowopsa kwa moyo wa wodwalayo.
Malizani kugwiritsa ntchito mankhwalawa pakuthandizira pang'onopang'ono, kuchepetsa mwatsatanetsatane tsiku lililonse. Ndi kusiyiratu kugwiritsa ntchito, ambiri mwa odwala ali ndi matenda akuti "achire", omwe angayambitse matenda atsopano.
Mukamatenga, kuwongolera kwa kuthekera kwa kukhazikika kwa maboma a manic, komwe nthawi zambiri kumawonedwa ndi cyclic komanso kuvuta kukhumudwa, kumafunikira.