Liraglutide zochizira kunenepa: malangizo a mankhwala

Radar amatanthauza chida monga Liraglutid. Amagwiritsidwa ntchito kuwongolera shuga m'magazi a odwala matenda ashuga. Mankhwalawa amapezeka nthawi zambiri pansi pa dzina la Viktoza kapena Saksenda.

Liraglutide ndiye chinthu chogwira pamaziko omwe adapangidwira. Ntchito yayikulu ya gawo ili ndikuchepetsa kuchuluka kwa shuga m'magazi.

Gwiritsani ntchito mankhwalawa mosamala kwambiri, chifukwa ali ndi zovuta komanso zotsutsana. Asanachitike, adokotala amafufuza ndi kusanthula chithunzi cha matendawa. M'tsogolomu, njira ya chithandizo iyenera kuyang'aniridwa kuti ipewe kukula kwa hypoglycemia ndi zovuta zina.

Kodi liraglutide ndi chiyani

Mu 2009, liraglutide ya mankhwala idawoneka ku Russia, yomwe imapangidwa ku Denmark ndipo imagwiritsidwa ntchito pochiza matenda osokoneza bongo popanda kudalira insulini. Gawo lofunikira ndi agonist (kopi) ya glucagon-ngati peptide GLP-1, pafupifupi siyimasiyana ndi analogue yachilengedwe, chifukwa chake thupi silizindikirika ngati thupi lakunja.

Limagwirira ntchito kuti muchepetse kunenepa

Chipangizocho chimapezeka mu cholembera cha jakisoni wa subcutaneous. Kupita kukhudzana ndi kapamba, kumalimbikitsa kubisika kwa insulin ndipo kumathandizanso kuti munthu akhale ndi vuto lalikulu. Zinapezeka kuti theka la odwala, kulemera kwake kumatsika ndi 5-10% m'mwezi wogwiritsidwa ntchito. Kuwotcha kwamafuta ndi kuchepa thupi kumachitika chifukwa choponderezedwa ndi njala komanso kugwiritsa ntchito mphamvu. Liraglutide zochizira kunenepa ali ndi izi:

• amachepetsa shuga
• zimachulukitsa chakudya,
• Malinga ndi ndemanga, imachepetsa kulakalaka.

Mankhwala okhala ndi liraglutide

Jakisoni yemwe ali ndi zinthu ndi wa gulu la ma insretins. Palibe magome omwe alipo. Awa ndi mankhwala a Viktoza ndi generic Saksenda (ali ndi chinthu chomwechi, koma amapangidwa ndi wina wopanga). Mankhwalawa onse amagwiritsidwa ntchito pochiza odwala matenda ashuga, kuchepa thupi kwa odwala akuluakulu. Amawerengera index yam'mimba yopitilira 30 kapena 27, ngati pali matenda oopsa.

Cholinga chachikulu cha liraglutide ndikuthandizira kapamba pakapangidwe ka insulin, ndipo chowonjezera ndikusintha kusintha kwa glucose kukhala mphamvu, osati mafuta. Cholembera cha syicinge cha Victoza chili ndi chophatikizira chogwira, chophatikizidwa ndi sodium hydrogen phosphate dihydrate, phenol, sodium hydroxide, madzi ndi propylene glycol. Syringe imodzi ili ndi 3 ml yankho, mtengo wamsika wamba ndi $ 158 kapena 9,500 rubles.

Victoza yakuchepetsa thupi amatha kusinthidwa ndi Saxenda, wopezekanso mwa zolembera, koma kale ma 5 ma PC. 3 ml ya yankho lililonse (mtengo wa ma ruble 27,000). Kuphatikiza apo, kaphatikizidwe kameneka ndikuphatikiza propylene glycol, sodium hydroxide, phenol, sodium hydrogen phosphate dihydrate (zikugwirizana ndi kapangidwe ka Viktoza). Mosiyana ndi Victoza, Saxenda ali ndi zovuta zochepa.

Contraindication

Zoletsa kwathunthu kugwiritsa ntchito mankhwala okhala ndi liraglutide:

• zotupa m'mimba,
• mavuto amisala
• matenda a chiwindi, kapamba,
• Mimba, kuyamwa,
• mtundu 1 shuga
• kumwa mowa panthawi yamankhwala (kuyanjana sikunayambike),
• matenda ashuga ketoacidosis,
• matenda aimpso, chiwindi,
• paresis am'mimba
• Hypersensitivity pazomwe zimapangidwira.

Zotsatira zokhudzana ndi kugwiritsidwa ntchito kwa mankhwala opangira liraglutide:

• matenda a mtima ndi mtima,
• kulephera kwa mtima
• kumwa mankhwala okhala ndi GLP-1,
• zaka mpaka 18 ndi zaka 75,
• Kulandila njira zochepetsera thupi.

Zotsatira zoyipa

Omwe amamwa mankhwalawa amatha kuyambitsa mavuto ena:

• achina,
• kuchepa kwamtima
• ziphuphu
• kudzimbidwa, kutsekula m'mimba, kuyamwa,
• mutu
• kusowa kwamadzi
• kukhumudwa, kutopa, ulesi, kuchepa kwa magwiridwe antchito,
• kukomoka.

Malangizo ogwiritsira ntchito Liraglutida

Kukonzekera kwa Saksenda ndi Viktoza kumatumizidwa kokha, kamodzi patsiku nthawi imodzi. Ndikofunikira kusankha jekeseni ntchafu, m'mimba kapena phewa. Mlingo woyambirira udzakhala 1.8 mg, pakapita nthawi umatha kubweretsedwa mpaka 3 mg. Simungathe kulowa kawiri pa tsiku limodzi. Kutalika kwa chithandizo kumatenga miyezi inayi mpaka chaka chimodzi, ndikofunikira kusewera masewera nthawi yomweyo, kutsatira zakudya. Pamodzi ndi liraglutide, thiazolidinediones ndi metformin zitha kukhazikitsidwa.

Momwe mungagwiritsire ntchito cholembera

Njira yothetsera vutoli imaperekedwa kokha. Madziwo ayenera kukhala ofunda. Magawo ogwiritsira ntchito:

1. Chotsani kapu pachigoba, chotsani cholembera ku singano, ndikuchigwira ndi kapu, ndikuyiyika mu nsonga. Tembenuzani ndi ulusi, tsekani singano.
2. Chotsani mpweya pochotsa kapu ku singano ndikutembenuzira kumapeto. Gwedezani syringe kuti mutulutse mpweya, kanikizani batani kuti dontho lithe kuchokera kumunsi kwa singano.
3. Tembenuzani batani la jakisoni kukhala muyeso wofunikira pamalowo potembenukira syringe. Nambala yomwe ili m'bokosi iwonetsa mlingo.
4. Nthawi iliyonse muyenera kupanga jakisoni kumalo ena. Yeretsani malo a jakisoni ndi mowa ndikupukuta, pukuta, gwiritsani syringe ndi dzanja limodzi, ndikukulungani ndi linalo. Ikani singano, amasula khola, kukanikiza batani m'manja, kumasulidwa pambuyo masekondi 10.
5. Chotsani singano pakhungu muli ndi batani. Tsitsani tsamba la jekeseni ndi chopukutira, onetsetsani kuti pali 0 pazenera.
6. Tulutsani singano, valani chipewa, mulizungulire, mutulutse singano, chotsani. Sinthani chipewa.
7. Sungani syringe yake pakalembedwe koyambirira. Sizoletsedwa kusiya singano pathupi ndikugwiritsa ntchito kawiri.

Analogs a Victoza ndi Saxend

Sinthani mankhwala ndi zida zotsatirazi zomwe zitha kugulidwa pamtengo wokwanira:

1. Forsyga - 2500 p., Amachepetsa shuga ya magazi.
2. Orsoten - 650 p., Makapisozi a kuchepa thupi, imathandizira kagayidwe kachakudya ka glucogone.
3. Liksumiya - 6750 p., Otsika magazi.
4. Ximia - 2000 p., Kugwiritsa ntchito kunenepa kwambiri.
5. Reduxin - ma ruble 1400, amachepetsa thupi, amathandizira kuti mafuta ayake.
6. Diagninide - ndi yotsika mtengo, ma ruble 200, amathandizira kunenepa kwambiri.
7. Belvik - ma ruble 13,000, amachepetsa chilako, sagulitsidwa ku Russia.
8. Baeta - ma ruble 8000, amino acid peptide yomwe imachepetsa m'mimba ndikuchepetsa chilako, imakhudza ma pancreatic receptors.

The zikuchokera, kumasula mawonekedwe ndi pharmacological kanthu

Mankhwalawa amapangidwa mwanjira yothetsera vuto lopanda utoto, lomwe limapangidwira makonzedwe osokoneza bongo. Chofunikira kwambiri ndi mankhwala a Lyraglutide.

Kuphatikiza apo, zigawo zikuphatikiza:

• propylene glycol
• hydrochloric acid
• phenol
• sodium hydrogen phosphate,
• madzi.

Ndi kapangidwe kameneka komwe kamayesedwa ngati koyenera kwambiri kukwaniritsa ntchito zomwe zapatsidwa mankhwala.

Mothandizidwa ndi chigawochi, njira yopangira insulin kudzera m'maselo a beta imathandizira kwambiri. Chifukwa cha izi, minofu komanso mafuta m'thupi zimatha kugwiritsa ntchito shuga ndikugawa pakati pa maselo, zomwe zimathandiza kuchepetsa kuchuluka kwa shuga m'magazi. Kutengera izi, titha kunena kuti mankhwalawa ndi hypoglycemic.

Kugwiritsa ntchito bwino kwa mankhwalawa ndikokwera kwambiri, kumadziwika ndi kuwonekera nthawi yayitali. Ndi kuyambitsa kwa mankhwala 1 nthawi patsiku, zotsatira zake zimapitirira kwa maola 24.

Zizindikiro ndi contraindication

Musanagwiritse ntchito liraglutide, muyenera kuwerengera malangizo ndikuwonetsetsa kuti chida ichi ndi choyenera kwa wodwala wina. Ngakhale madotolo amayenera kuyeserera kuti apewe zovuta. Sizovomerezeka kumwa mankhwalawo.

Mankhwala a mtundu wachiwiri wa shuga amagwiritsidwa ntchito. Amatengedwa kuti ndi othandiza ndipo amagwiritsidwa ntchito molumikizana ndi mankhwala ena a gulu la hypoglycemic. Koma nthawi zina Lyraglutide imathandizanso mu monotherapy.

Kufunika koyesedwa koyambirira kwa wodwalayo kumachitika chifukwa cha zotsutsana zomwe zimapezeka ndi mankhwala.

Mwa iwo amatchedwa:

• kukhudzika kwa thupi pazinthu zilizonse zomwe zimapangidwa,
• matenda a chiwindi
• kuphwanya impso ntchito,
• kukhalapo kwa njira zotupa m'mimba,
• mtundu woyamba wa matenda ashuga
• kapamba
• kulephera kwa mtima
• matenda a endocrine
• nthawi yapakati
• kuyamwa.

Kuphatikiza pazoponderezedwa kwambiri, pali malire:

• matenda a mtima
• wodwala mpaka zaka 18,
• m'badwo wa senile.

Muzochitika izi, pamakhala chiwopsezo cha zovuta, koma moyang'aniridwa ndi katswiri amatha kukhala osalowerera. Chifukwa chake, nthawi zina odwala oterewa amapangidwabe Liraglutid.

Malangizo ogwiritsira ntchito

Mankhwalawa amagwiritsidwa ntchito ngati jakisoni, yemwe amayenera kuperekedwa mwachangu. Kugwiritsa ntchito mankhwala osokoneza bongo kapena mu mnofu kumaloledwa.

Malo oyenera kwambiri a jakisoni ndi khoma lakunja lam'mimba, ntchafu kapena phewa. Masamba a jakisoni amayenera kusinthidwa pafupipafupi kuti lipodystrophy isachitike. Lamulo linanso - kukhazikitsidwa kwa mankhwalawa kumayenera kuchitika nthawi yomweyo.

Mlingo wa mankhwalawa umatsimikiziridwa payekhapayekha. Nthawi zambiri, chithandizo chimayamba ndi gawo la 0,6 mg. Majakisoni amachitika kamodzi patsiku. Ngati ndi kotheka, mulingo umakwezedwa ku 1,2 ngakhale 1,8 mg. Kugwiritsidwa ntchito kwa liraglutide kuchuluka kwa zoposa 1,8 mg ndikosayenera.

Nthawi zambiri, kuphatikiza pa mankhwalawa, zinthu zopangidwa ndi Metformin zimagwiritsidwa ntchito.

Pofuna kupewa matenda a hypoglycemic, njira ya chithandizo iyenera kuyang'aniridwa. Onetsetsani kuti mwayang'ana magazi anu ndikuwongolera njira yanu yochiritsira. Kusintha popanda kuvomerezedwa ndi katswiri ndikosayenera.

Kanema malangizo kwa subcutaneous makonzedwe:

Kuchita ndi mankhwala ena

Liraglutide amatha kuchititsa kuti mankhwala ena azigwira bwino ntchito. Chifukwa chake, odwala ayenera kudziwitsa adokotala za mankhwala aliwonse omwe angagwiritse ntchito kuti athe kupereka mankhwala okwanira. Nthawi zambiri, zotsatira zoyipa zimachitika chifukwa chakuti wodwalayo amagwiritsa ntchito mankhwala osagwirizana.

Chenjezo ndi kusintha kwa mankhwalawa ndikofunikira pokhudzana ndi mankhwalawa:

• othandizira a hypoglycemic
• beta blockers,
• okodzetsa
• ACE zoletsa
• Mankhwala a anabolic
• mankhwala oletsa kubereka,
• mankhwala antimycotic
• salicylates, etc.

Kuphatikiza kwa liraglutide ndi mankhwala ena nthawi zambiri kumaloledwa, koma nthawi zambiri ndikofunikira kuyang'ana magazi a wodwalayo ngati ali ndi shuga. Pokhapokha pakuchitika zinthu zabwino, mulingo umachulukitsa, ndikuwoneka ngati zizindikiro za hypoglycemia, akuyenera kuichepetsa.

Kukonzekera kofananako kumapiritsi

Zifukwa zomwe akatswiri amagwiritsa ntchito fanizo la mankhwalawa zimatha kukhala zosiyana. Kwa odwala ena, mankhwalawa sioyenera chifukwa choponderezedwa, ena amadandaula za zoyipa, kwa ena, mtengo wake ungaoneke wosavomerezeka.

Sinthani mankhwalawa motere:

1. Novonorm. Maziko ake ndi Repaglinide. Amamasula ngati mapiritsi. Dokotalayo amakupatsani mlingo wa mankhwalawo, kutengera zomwe chithunzi cha matenda. Simungathe kuyamba kutenga Novonorm nokha, chifukwa ali ndi contraindication.
2. Reduxin. Mankhwala ali ndi hypoglycemic. Kuphatikizika kwake kumaphatikiza zinthu ziwiri - Metformin ndi Sibutramine. Reduxine ukhoza kugwiritsidwa ntchito m'mapiritsi kapena mapiritsi.
3. Diaglinide. Zapangidwa kuti azikupanga pakamwa, zomwe zimayang'ana kwambiri odwala omwe ali ndi matenda ashuga. Chofunikira chachikulu pakuphatikizidwa kwake ndi Repaglinide. Chidacho chimathandizira kuyang'anira kuchuluka kwa shuga.
4. Forsyga. Chofunikira chake ndi Dapagliflozin. Thupi limakhala ndi vuto la hypoglycemic, lingathandize kuonda. Kugwiritsa ntchito, muyenera kutsatira malangizo azachipatala.

Malingaliro odwala

Malinga ndi ndemanga za odwala omwe adatenga Liraglutide, titha kudziwa kuti mankhwalawa salola munthu aliyense bwino. Amanenedwa kuti ali ndi zovuta zoyipa mutatenga. Ambiri amalingalira za kuchepa thupi kukhala bonasi yabwino.

Sindinachitire Liraglutide kwakanthawi. Poyamba zonse zinkayenda bwino, ngakhale kusakumana ndi zinthu zotsutsa ndidadabwa. Ndipo kufufuzaku kudawonetsa kuti ndili ndi kapamba. Ndinafunika kukana mankhwalawo.

Kuyamba kwa mankhwalawa ndimankhwala kunali koopsa. Ndinkazunzidwa ndi nseru, mutu wanga umadwalika nthawi zonse, ndipo chifukwa cha zovuta zakanthawi zinkandivuta kugwira ntchito ngakhale kutuluka pabedi. Kale amafuna kufunsa mankhwala omwe atha kusintha. Zinayima kuti mulingo wa shuga ndi wabwinobwino komanso wosasunthika. Kenako thupi mwina lidagwiritsidwa ntchito, chifukwa zizindikilo zonse zosasangalatsa zidasowa. Ndikupitilirabe chithandizo mpaka pano. Ndinaona kuti zimathandiza kuti muchepetse kunenepa, chifukwa kulakalaka kumachepa. Kwa theka la chaka ndinali ndi 15 kg zochepa, zomwe zimandilola kumva bwino - katundu wowonjezereka anasowa.

Ndimagwiritsa ntchito Liraglutid posachedwa, koma imandikwana. Shuga adatsikira ku mulingo wabwinobwino, palibe zoyipa zomwe zimachitika, ngakhale ndinali ndi nkhawa kwambiri. Ndikufuna kuchepetsa thupi (ndinamva kuti imagwiritsidwanso ntchito kwa izi), koma pakadali pano kuchepa kwa thupi ndi kochepa, makilogalamu atatu okha.

Sikuti aliyense angagule mankhwalawa, chifukwa ndi amtengo wokwera mtengo kwambiri. Mtengo woyenerana uli mumitundu yosiyanasiyana ya ma 10,000 rubles.