Mapiritsi a Thrombo ACC

Mtundu wa kutulutsidwa kwa Thrombopol ndi mapiritsi okhala ndi matendawa: pinki, biconvex, ozungulira (m'matumba a ma PC 10. Mu katoni kamatumba 3, 5 kapena 6 matuza, m'matumba a ma PC 25., Pamakatoni okhala ndi matuza awiri).

Piritsi 1:

• yogwira mankhwala: acetylsalicylic acid - 75 kapena 150 mg,
• othandizira zigawo: wowuma chimanga, sodium carboxymethyl wowuma, cellcrystalline cellulose,
• chipolopolo: hypromellose, Acosterone Ndi osakanikirana mapiritsi ounikira, kapangidwe kake ndi sodium lauryl sulfate, sodium hydrogen carbonate, methaconic acid Copolymer (mtundu C), talc, triethyl citrate, titanium dioxide, colloidal silicon dioxide, utoto wofiirira (Ponceau 4R).

Mankhwala

Thrombopol ndi amodzi a NSAIDs (mankhwala omwe si a antiidal anti-yotupa), othandizira antiplatelet.

Maziko a zochita za acetylsalicylic acid ndizolepheretsa za COX-1 (cycloo oxygenase), zomwe zimabweretsa kutsekeka mu kapangidwe ka thromboxane A₂ ndi kuponderezana kwa kuphatikiza kuphatikizira kwa maselo.

Mphamvu ya antiplatelet imachitika ngakhale pambuyo pa kugwiritsidwa ntchito kwa ochepa Mlingo wa mankhwalawa, kutalika kwa vuto lake pambuyo pokhapokha patatha masiku 7. Acetylsalicylic acid utha kugwiritsidwa ntchito pochiza komanso kupewa matenda / zinthu zotsatirazi: kulowerera m'mitsempha, kulowetsedwa kwa mitsempha ya varicose, matenda a mtima.

Kuphatikiza apo, mankhwalawa ali ndi analgesic, anti-kutupa komanso antipyretic.

Chifukwa cha kuphatikizika kwa mapiritsi ophatikizika, acetylsalicylic acid imatulutsidwa m'malo ena amchere a duodenum, omwe amathandiza kuchepetsa kukwiya kwake kwa mucosa ya m'mimba.

Pharmacokinetics

Kulowetsedwa kwa acetylsalicylic acid kuchokera ku Thrombopol kumayamba patatha maola 3-4 mutatha kumwa mankhwalawa (izi zikutsimikizira kutsekereza kwa mapiritsi osokoneza bongo m'mimba). C_max (kuchuluka kwa kuchuluka kwa chinthu) mu plasma pafupifupi 6.72 ndi 12,7 μg / ml (mapiritsi a 75 ndi 150 mg, motsatana), nthawi yoti mufikire ndi pafupifupi maola 2-3. Kuyamwa kwa mankhwalawa kumachepetsa kukhalapo kwa chakudya m'mimba.

AUC (dera lomwe lili pansi pa ndende nthawi yayitali) ndi 56.42 ndi 108.08 μg × h / ml (mapiritsi a 75 ndi 150 mg, motero).

Acetylsalicylic acid kwambiri ndipo amalowa mwachangu zamadzimadzi m'thupi ndi zimakhala zambiri. Kuchuluka kwa mapuloteni a plasma kumatsimikiziridwa ndi ndende.

Kugawidwa kwa wachibale kuli pafupifupi 0,15-0.2 l / kg; kumachulukana nthawi yomweyo ndi kuwonjezeka kwa seramu ndende ya thrombopol m'magazi.

Mosiyana ndi ma salicylates ena, motsutsana ndi kukhazikika kwa mankhwalawa mobwerezabwereza, osakhala hydrolyzed acetylsalicylic acid sadziunjikira mu seramu yamagazi.

Mwapang'onopang'ono acetylsalicylic acid umapangidwa nthawi ya mayamwidwe. Izi zimachitika mchikakamizo cha michere makamaka mu chiwindi. Ma metabolites otsatirawa amapangidwa (amapezeka mumkodzo ndi minofu yambiri): phenyl salicylate, glucuronide salicylate, ndi salicyluric acid.

T_1/2 (theka-moyo) wa acetylsalicylic acid kuchokera m'madzi am'magazi ali pamtunda kuchokera pa mphindi 15 mpaka 20.

1% yokha ya zakumwa zamkamwa zomwe amaziwonetsa mu impso ya non-hydrolyzed acetylsalicylic acid, ena onse monga salicylates ndi metabolites awo.

Pazowonongeka aimpso ntchito, 80-100% imodzi ya mankhwala amayamba impso mkati mwa maola 24-72.

Njira ya metabolic mwa akazi imacheperachepera (chifukwa cha kuchepa kwa ma enzymes mu seramu yamagazi).

Odwala omwe ali ndi vuto la impso, komanso azimayi oyembekezera komanso akhanda, othandizira amatha kuthana ndi bilirubin kuchokera kumayanjano ndi albumin, omwe amachititsa kuti ma bilirubin encephalopathy aoneke.

Zizindikiro zogwiritsidwa ntchito

• angina wosakhazikika,
• pachimake myocardial infarction (kupewa chapakati myocardial infarction pamaso pa zinthu zoopsa, makamaka matenda ashuga, hyperlipidemia, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba, komanso kupewa kulowetsedwa kwa myocardial),
• sitiroko (kupewa, kuphatikiza odwala omwe ali ndi matenda osakhalitsa amiseche),
• ngozi yochepa yam'chiberekero (kupewa),
• thromboembolism (kupewa mu nthawi yaoperative komanso pambuyo pamavuto olowera pamadziwo, makamaka, corteryary artery endarterectomy, carotid artery angioplasty, arteriovenous shunting),
• mitsempha yakuya ndi thromboembolism yam'mitsempha yam'mimba komanso nthambi zake (kupewa, kuphatikiza odwala pambuyo pakupanga opaleshoni yayitali nthawi yayitali).

Contraindication

• kuchuluka kwa zotupa ndi zilonda zam'mimbamo zam'mimba,
• kuphatikiza kwa mphumu ya bronchial, polyposis ya paranasal sinuses / mphuno ndi tsankho la acetylsalicylic acid,
• hemorrhagic diathesis,
• m'mimba,
• munthawi yomweyo kugwiritsa ntchito methotrexate pa 15 mg pa sabata kapena kupitilira,
• mphumu ya bronchial yoyambitsidwa ndi salicylates ndi NSAIDs,
• Ine ndi III timayesa kubereka, komanso nthawi yoyamwitsa.
• wazaka 18
• kusalolera kwa aliyense pazinthu zilizonse za mankhwalawo, komanso ma NSAID ena.

Wachibale (Thrombopol amalembedwa moyang'aniridwa ndi achipatala):

• polyposis ya mphuno,
• gout
• matenda opumira kwambiri,
• Hyperuricemia
• aimpso / chiwindi kulephera,
• mbiri yam'mimba ndi zilonda zam'mimba kapena magazi am'mimba,
• Mphumu ya bronchial,
• hay fever
• ziwengo
• kugwiritsa ntchito munthawi yomweyo ndi mankhwala opatsirana,
• munthawi yomweyo kugwiritsa ntchito methotrexate muyezo wa 15 mg pa sabata,
• II trimester wa pakati.

Zotsatira zoyipa

• kugaya chakudya dongosolo: kuchuluka kwa chiwindi michere, nseru, kusanza, kupweteka kwam'mimba, kupweteka pamimba, zilonda zam'mimba zam'mimba ndi duodenum, kuphatikizapo kuphatikizidwa, kutaya magazi m'mimba,
• chapakati mantha dongosolo: tinnitus, chizungulire,
• kupuma dongosolo: bronchospasm,
• matupi awo sagwirizana: edema ya Quincke, urticaria,
• hematopoietic dongosolo: kuchuluka magazi, osowa - kuchepa kwa magazi.

Bongo

Zizindikiro zoyambirira za mankhwala osokoneza bongo zimawonekera mu mseru, kusanza, tinnitus ndi kupuma mwachangu, kuphatikiza, mavuto otsatirawa akhoza kukhala: kuwonongeka kwa m'maso, kumva makutu, phokoso la magalimoto, kupweteka kwa mutu, kugona, Hyperthermia, kupweteka. Ndi kuledzera kwakukulu, kusokonezeka m'madzi-electrolyte ndi acid-base usawa (kuchepa kwa madzi ndi metabolic acidosis) kumatha kuwoneka.

Zizindikiro za kuledzera kofatsa / kochitika kumachitika pambuyo poti mugwiritsa ntchito 150-300 mg / kg acetylsalicylic acid. Mankhwala osokoneza bongo amakula ndi 300-500 mg / kg. Mlingo woposa 500 mg / kg umatha kupha.

Palibe mankhwala enieni a thrombopol. Monga chithandizo, kuti muchepetse kuyamwa kwa mankhwalawa, njira zotsatirazi zikusonyezedwa: kusanza ndikusambitsa m'mimba. Izi zimathandiza kwa maola 3-4 mutatha kumwa mankhwalawa, pakumwa mankhwala ochuluka, nthawi imeneyi amawonjezeredwa mpaka maola 10. Kuti muchepetse kuyamwa kwa chinthucho, ndikofunikira kutenga kuyimitsidwa kwamphamvu kwa kaboni (wamkulu mlingo - 50-100 g, ana - 30-60 g), poyang'anira kuchuluka kwa ma electrolyte kuyenera kukhazikitsidwa (ngati kuli koyenera, kuyenera kuyambiridwanso munthawi yake).

Mankhwalawa acidosis ndi imathandizira excretion wa acetylsalicylic acid ndi impso, intravenous makonzedwe a sodium bicarbonate akuwonetsedwa, pH iyenera kusungidwa mndandanda wa 7-7.5.

Pankhani ya kuledzera kwambiri, hemodialysis kapena peritoneal dialysis amasonyezedwa.

Chifukwa cha kupuma kwa acidosis, kumwa mankhwala omwe amaletsa chapakati mantha dongosolo (monga barbiturates) amaletsedwa. Pamaso pa zovuta za kupuma, ndikofunikira kuonetsetsa patency ya airway ndi mpweya. Ngati ndi kotheka, chitani ntchito yolimbitsa thupi ndi kupereka mpweya wabwino.

Malangizo apadera

Acetylsalicylic acid imatha kuyambitsa bronchospasm, komanso kungayambitse kugwidwa ndi mphumu komanso zochitika zina za hypersensitivity. Zowopsa zomwe zili pachiwopsezo ndi mbiri ya mphumu ya bronchial, fever fever, mphuno yam'mimba, matenda othandizira kupuma, zovuta zina zamankhwala ena (mwachitsanzo, kusintha kwa khungu, kuyabwa, mng'oma).

Kugwiritsa ntchito acetylsalicylic acid kumatha kuyambitsa magazi osiyanasiyana pakachitika / atachitidwa opaleshoni. Pankhani imeneyi, masiku 5-7 asanagwiridwe ntchito, chithandizo chamankhwala chiyenera kusiyidwa.

Kuopsa kwa magazi kumawonjezeka ndi kuphatikizira kwa mankhwala ophatikizana ndi ma anticoagulants, ma cellulin othandizira ma cell, komanso mankhwala a thrombolytic.

Mlingo wocheperapo wa acetylsalicylic acid mukakumana ndi vuto la m'maso (kuchepa kwa uric acid excretion) kungayambitse gout.

Ndi kuphatikiza kwa thrombopol ndi methotrexate, kuchuluka kwa zovuta zoyambira kuchokera ku ziwalo za hematopoietic kumawonjezeka.

Mlingo waukulu wa acetylsalicylic acid umatulutsa hypoglycemic, womwe uyenera kuganiziridwa kwa odwala omwe ali ndi shuga omwe amalandila mankhwala omwe ali ndi vuto la hypoglycemic.

Ndi kuphatikiza kwa glucocorticosteroids omwe ali ndi thrombopol, kuchepa kwake m'magazi kumawonedwa, ndipo kuthetsedwa kwa glucocorticosteroids, mankhwala ochulukirapo a salicylates amatha.

Kugwiritsira ntchito pamodzi ndi ibuprofen sikulimbikitsidwa, chifukwa kumachepetsa mphamvu ya acetylsalicylic acid.

Kuphatikiza kwa acetylsalicylic acid ndi ethanol kumawonjezera mwayi kuwonongeka kwa mucous membrane wa m'mimba thirakiti ndi nthawi yayitali yotuluka magazi.

Mankhwala osokoneza bongo oopsa kwambiri odwala okalamba. Chifukwa chakuti odwala azaka zopitilira 65, kuchepa kwa ntchito yaimpso ndikotheka, gulu la odwala liyenera kupatsidwa thrombopol mu Mlingo wochepetsedwa.

Mimba komanso kuyamwa

• Ine ndi III okonzekera kutenga pakati: mankhwalawa amatsutsana, kugwiritsa ntchito Thrombopol mu I trimester kumabweretsa kugawanika kwa chapamwamba ndi zolakwika za mtima, mu trimester ya III - kuletsa ntchito, kutsekedwa kwa nthawi yayitali kwa ductus arteriosus mu mwana wosabadwayo, kuchuluka kwa magazi kwa mayi / mwana wosabadwayo kale kubereka kungayambitse kukha magazi kwakanthawi, makamaka ana akhanda,
• II trimester yokhala ndi pakati: Thrombopol ikhoza kugwiritsidwa ntchito pokhapokha kuwunika mozama phindu / chiopsezo,
• mkaka wa m`mawere: mankhwala ndi contraindified.

Kuyanjana kwa mankhwala osokoneza bongo

Mankhwala osokoneza bongo, momwe amathandizira akaphatikizidwa ndi thrombopol:

• methotrexate: imalumikizidwa ndi kuchepa kwa mawonekedwe a impso ndi kuchoka kwake pakulankhulana ndi mapuloteni, kuphatikiza kumatsutsana kapena kumafunikira kusamala (mukamagwiritsa ntchito Mlingo pamwambapa kapena mpaka 15 mg pa sabata,)
• heparin ndi anticoagulants osalunjika: ophatikizidwa ndi vuto la kupatsidwa zinthu za m'magazi komanso kusamutsa anticoagulants osalunjika polumikizana ndi mapuloteni,
• thrombolytic mankhwala ndi mapuloteni obisika othandizira (ticlopidine),
• digoxin: yokhudzana ndi kuchepa kwa impso zake,
• hypoglycemic agents (insulin ndi sulfonylurea zotumphukira): zimaphatikizidwa ndi kuchuluka kwa hypoglycemic ya acetylsalicylic acid yokha pamtunda waukulu komanso kuchoka kwa sulfonylurea kuchokera ku mapuloteni,
• valproic acid: chifukwa chosamutsa mgwirizano wake ndi mapuloteni,
• NSAIDs
• sulfonamides (kuphatikiza co-trimoxazole),
• barbiturates
• mchere wa lithiamu.

Mankhwala osokoneza bongo omwe amachepetsa limodzi ndi thrombopol:

• sulfinpyrazone, probenecid, benzbromaron ndi mankhwala ena olimbana ndi gout omwe amalimbikitsa uric acid excretion: omwe amaphatikizidwa ndi kupikisana kwamatenda a uric acid,
• antihypertensive othandizira, kuphatikizapo angiotensin otembenuza enzyme zoletsa,
• aldosterone antagonists (makamaka spironolactone),
• loop diuretics (makamaka furosemide).

Zochitika zina:

• mowa: zowonjezera
• glucocorticosteroids ogwiritsa ntchito mwadongosolo: kufooketsa zochita za thrombopol.

Kufotokozera mwachidule za mankhwalawa

Thrombo ACC imapangidwa ngati mapiritsi ang'onoang'ono oyera owoneka bwino okhala ndi zokutira zonyezimira zomwe zimasungunuka mosavuta m'mimba. Moyo wa alumali wa mankhwala suwaposa zaka zitatu, muyenera kusungira phukusi kutali ndi dzuwa. The mankhwala:

• yogwira mankhwala: acetylsalicylic acid, malinga ndi kuchuluka kwake, mapiritsi ndi 50 kapena 100 mg,
• zothandizira.

Mankhwalawa amaperekedwa m'malo amtundu wa mankhwala popanda mankhwala. Komabe, iyenera kugwiritsidwa ntchito mosamala komanso Mlingo woyenera. Mankhwala osokoneza bongo makamaka osayenera kwa okalamba.

Mphamvu ya mankhwalawa imachokera pazofunikira pazochitika zoyambira - salicylic acid: kuchepa kwa njira yotupa, kuchepa kwa kutentha, komanso mphamvu ya analgesic. Ether yake imachepetsa kaphatikizidwe ka thromboxane A2 mu mapulateleti, potero amathandizira kupewa mapangidwe a magazi. Mphamvuzi imadziwoneka yomweyo mutagwiritsidwa ntchito ndi Thrombo ACC ndipo imakhalapo pakatha masiku 7 mutatenga piritsi limodzi.

Zizindikiro za mankhwala

Zotsatira za zochita za gawo likulu la mankhwalawa limalola kuti liperekedwe kwa prophylaxis ndi chithandizo (onse awiriwa a monotherapy komanso osakanikirana ndi njira zina) za myocardial infarction, ischemia, varicose. Zizindikiro zazikulu zomwe Trombo ACC idasankhidwa:

• pamaso pa angina pectoris,
• prophlaxis yoyamba ndi sekondale pachipatala chovuta kwambiri cha matenda amtima kuchokera pakupezeka kwa myocardial infarction, makamaka ngati wodwala wapezeka ndi matenda a shuga, kunenepa kwambiri, zizolowezi zoyipa (chikonga chamledzera komanso uchidakwa), ukalamba wolimba,

Kugwiritsa ntchito kwa Thrombo ACC kuphatikiza ndi mankhwala ena ndizovomerezeka pokhapokha mukakambirana ndi adokotala: mapiritsi amawonjezera mphamvu yofunikira kwambiri pakukonzekera zamankhwala (kuphatikizira omwe cholinga chake ndi kuchiritsa mtima), pachifukwa ichi zotsatira za mankhwalawa zimatha kukhala zosatsimikizika.

Malangizo a kayendetsedwe koyenera ka Thrombo ACC

Mapiritsi ayenera kumwedwa tsiku kapena madzulo, asanakadye chakudya ndikutsukidwa ndi madzi ambiri. Thrombo amatchulidwa ngati maphunziro, nthawi yomwe ayenera kutsimikiza ndi dokotala potengera matendawa. Ngati mankhwalawo atha kuthandiza ndipo osayambitsa mavuto, ndiye kuti nthawi yoyendetsera ikhoza kuchuluka.

Kumwa Trombo ACC pamimba yopanda kanthu ndizoletsedwa!

Mlingo wamba wamankhwala ndi 50-100 mg patsiku. Mlingo wokwera (mpaka 200 mg) amapatsidwa mankhwala othandizira kwambiri a mtima.

Mankhwala osokoneza bongo a mankhwala ndi osowa kwambiri, popeza mapiritsiwo amakhala ndi mphamvu yochepa yogwira.

Mwa anthu okalamba, kugwiritsa ntchito mankhwala ochulukirapo kumatha kuyambitsa zovuta zingapo:

• kusokonezeka kwamphamvu kwa kayendedwe,
• mseru waukulu ndi kusanza,
• kufooka wamba
• kusinthasintha kwa mtima komanso kuchepa kwa magazi,
• aimpso ndi chiwindi ntchito.

Pa gawo loyambirira la mankhwala osokoneza bongo, ndikokwanira kutenga makala oyambitsa, kuyeretsa m'mimba ndikubwezeretsa bwino-electrolyte bwino pogwiritsa ntchito mankhwala ndi / kapena wowerengeka. Pankhani ya kuchuluka kwambiri, kugonekedwa kuchipatala ndi diuresis, hemodialysis, kutukusira kwa m'mimba ndi matumbo, kubwezeretsanso acid-base usawa ndikukonza chithandizo ndikofunikira.

Zofanizira zamankhwala a Thrombo ACC

Thrombo ACC ili ndi mitundu yambiri yosiyanitsa, motero kusankha mankhwala oyenera molingana ndi mawonekedwe ake, kayendetsedwe kake, Mlingo ndi malire omwe sangathe sangakhale ovuta.

Mukasintha Thrombo ACC ndi mankhwala ena, muyenera kufunsa dokotala kuti mugwirizane ndi mankhwala ena.

Wopanga, mawonekedwe omasulira, kapangidwe, Mlingo, kufotokoza

Thrombo ACC imapangidwa ndi kampani yopanga mankhwala ku Austria yotchedwa GL. Pharma GmbH, yomwe mitengo yake ili mumzinda wa Pannach. Ku Russia, woyimira mafakitala aku Austria ndi kampani "Valeant", yomwe ili ku adilesi: 115162, Moscow, st. Shabolovka, nyumba 31, nyumba 5. Ndi ku adilesi iyi komwe mutha kutumiza zofunsa zonse zokhudza mankhwalawa.

Thrombo ACC imapezeka mu mtundu umodzi - ndiye mapiritsi amkamwaenteric wokutira filimu wokutira. Mapiritsiwo ali ndi matuza (konvalyutki) opangidwa ndi aluminiyamu ndi polyvinyl chloride, omwe, amawaika m'mabokosi a makatoni pamodzi ndi pepala lokhala ndi malangizo ogwiritsa ntchito. Mumabokosi - 14 kapena 20 mapiritsi.

Mapiritsi a Thrombo ACC ali ndi acetylsalicylic acid monga chophatikiza, chomwe chimadziwika kwambiri monga Aspirin. Koma mosiyana ndi gulu laling'ono la Aspirin lokhala ndi antipyretic ndi analgesic, kapangidwe ka Trombo ACC kamakhala ndi acetylsalicylic acid mumlingo wocheperako, womwe umapereka mulingo wosiyana pang'ono, womwe ndi antiplatelet. Chifukwa chake, mapiritsi a Thrombo ACC, acetylsalicylic acid imakhala mumtundu wambiri - 50 mg kapena 100 mg. Mlingo wambiri ndi wocheperako, chifukwa chake mankhwalawa amatha kugwiritsidwa ntchito pokhapokha, monga anthu akunenera, "kuwonda magazi", osachepetsa ululu ndikuchepetsa kutentha kwa thupi. Zachidziwikire, ngati mukufuna, mutha kugwiritsa ntchito Thrombo ACC kuti muchepetse kutentha, koma chifukwa cha izi muyenera kutenga mapiritsi asanu, omwe ali ofanana ndi piritsi limodzi la Aspirin wamba. Ndipo izi ndizosatheka komanso zoipa.

Koma kuloweza Trombo ACC ndi Aspirin wokhazikika ndizotheka, popeza zomwe zimagwira ndizofanana. Koma pokhapokha ngati piritsi la Aspirin padzayenera kugawidwa magawo atatu kapena atatu kuti mutenge mulingo wa acetylsalicylic acid mu 50-100 mg.

Monga zigawo zothandizira, mapiritsi okhala ndi mulingo wa 50 mg ndi 100 mg ali ndi zinthu zomwezo: microcrystalline cellulose, lactose monohydrate, colloidal silicon dioxide ndi wowuma wa mbatata. Chipolopolo cha mapiritsi a 100 mg ndi 50 mg mulinso zinthu zomwezo, ndizo: talc, triacetin, kopolymer wa methaconic acid ndi ethyl acrylate (1: 1) (Eudragit L).

Mapiritsi a onse Mlingo (50 mg ndi 100 mg) amawapaka oyera, ali ndi mawonekedwe ozungulira a biconvex, mawonekedwe owala kapena osalala pang'ono.

Thrombo ACC 100 ndi 50

Nthawi zambiri, pakulankhula kwa tsiku ndi tsiku, kuti zitheke, manambala amawonjezeredwa ku mayina a mankhwala omwe amatanthauza Mlingo wa chinthu. Kupanga "mayina" kwatsopano kumavomerezedwa, chifukwa chake akatswiri azamankhwala, madokotala, komanso odwala nawonso amawamvetsetsa. Izi zikugwira ntchito mokwanira kwa Thrombo ACC, pomwe mayina atsopano "Thrombo ACC 100" ndi "Thrombo ACC 50" amatanthauza muyeso wamapiritsi amodzi amomwewo.

Palibe kusiyana, kupatula pa kuchuluka kwa zomwe zimagwiritsidwa ntchito, pakati pa Thrombo ACC 50 ndi Thrombo ACC 100, chifukwa chake sitiganizira za mankhwala omwewo padera ndi mitundu yayikulu. Mosiyana ndi izi, m'malemba omwe ali pansipa, zambiri zomwe zikuperekedwa zikukhudza Terombo ACC pa mlingo uliwonse - onse 50 mg ndi 100 mg. Ndipo ngati kuli kofunikira kutsindika zizindikiro kapena mawonekedwe a mtundu wina, ndiye kuti tichita izi ndi cholinga, koma mwanjira ina zonse zomwe zingakhudzidwe ndi Trombo ACC mu Mlingo onse.

Zochizira

Thrombotic ACC imakhala ndi antiplatelet athari, yomwe imakhala ndikuchepetsa kumamatira kwa mapulosi ndi maselo ofiira amwazi. Kuphatikiza apo, magazi omwe amapangidwa ndi magazi amachepetsedwa pakati pawo komanso khoma lamitsempha yamagazi. Chifukwa cha izi, magazi amakhala amadzimadzi, osasinthika, osavuta komanso ozungulira bwino m'matumbo, samayenda, samapangika. Mphamvu ya antiplatelet ya Thrombo ACC chifukwa cha kusintha kwa kayendedwe ka magazi imathandizanso kupanga mapangidwe am'magazi m'mitsempha yosiyanasiyana, yomwe, imathandizira kupewa mikwingwirima yayikulu ikubwera chifukwa chophulika kwa mitsempha yamagazi ndi thrombi (kugunda kwa mtima, stroko, thromboses, pulmonary embolism, etc.).

Acetylsalicylic acid, yomwe ndi gawo la Thrombo ACC monga chogwiritsa ntchito, pakadali pano ndi ena mwa omwe amagwiritsidwa ntchito kwambiri. Mphamvu yake ya antiplatelet imakhala ndi njira zingapo. Chifukwa chake, acetylsalicylic acid imakhudza ntchito ya ma enzyme osiyanasiyana omwe amathandizira kupanga zinthu zina ndikupangitsa enafe.

Kuphatikiza pa antiplatelet athari, acetylsalicylic acid imakhalanso ndi vuto la fibrinolytic, lomwe limakhala ndi kusungunuka kwamagazi komwe kumapangapo ndikupanga maselo ofiira a m'magazi. Acetylsalicylic acid imachepetsanso kuchuluka kwa zophatikizika II, VII, IX, ndi X m'magazi, zomwe zimathandizanso kupanga mapangidwe a thrombus.

Pakukula kwa fibrinolytic ndi antiplatelet kanthu, acetylsalicylic acid amatengedwa mu Mlingo wotsika - 75 - 325 mg patsiku. Ichi ndichifukwa chake mapiritsi a Trombo ACC amakhala ndi 50 mg kapena 100 mg ya acetylsalicylic acid. Mphamvu ya antiplatelet imapitirira kwa sabata limodzi pambuyo pa mtundu umodzi wa Thrombo ACC.

Ndi omwe afotokozeredwa acetylsalicylic acid omwe amagwiritsidwa ntchito kupewa ndi kuchiza matenda amtima, matenda a mtima, zovuta za mitsempha ya varicose ndi matenda ena omwe ndi owopsa pakupanga magazi.

Mukamatenga thrombo, ACC imagwira mwachangu komanso mokwanira. Chifukwa cha kuphimba kwa enteric, piritsi silikhala lopweteketsa mtima komanso kuvulaza kwa mucosa ya m'mimba. Pambuyo polowa m'magazi, acetylsalicylic acid imasandulika kukhala salicylic acid, yomwe imapereka zotsatira zake. Kupitilira apo, mchere wa salicylic sukusakanikirana m'chiwindi ndikupanga phenyl salicylate, salicylate glucuronide ndi salicyluric acid, womwe, umaperekedwa kwa ziwalo zonse ndi minyewa. Salicylic acid imadutsa mkaka wa m'mawere ndikudutsa placenta. Mwa akazi, kutembenuka kwa acetylsalicylic acid mthupi kumayamba pang'onopang'ono kuposa amuna chifukwa chothamanga kwa ma enzymes.

Acetylsalicylic acid imayikidwa mu mawonekedwe a metabolites ndi impso mkati mwa maola 24 mpaka 72. Ngakhale mobwerezabwereza makonzedwe, mankhwalawa samadziunjikira mu seramu yamagazi.

Kutenga?

Mapiritsi a Thrombo ACC 50 mg ndi 100 mg ayenera kumwedwa nthawi yomweyo musanadye, kutsukidwa ndi madzi ambiri - osachepera kapu (200 ml). Kumbukirani kuti simungathe kumwa Thrombo ACC pamimba yopanda kanthu, chifukwa izi zimatha kuyambitsa kukwiya komanso kupweteka kwam'mimba. Onetsetsani kuti mwadya nthawi yomweyo pambuyo pa thrombotic ACC. Nthawi yomweyo, mawu oti "idyani" sakutanthauza chakudya chovuta, koma kugwiritsa ntchito zakudya zochepa zomwe zimakwaniritsa m'mimba. Mwachitsanzo, mutatenga Thrombo ACC ndikokwanira kudya nthochi zingapo, sangweji, phula laling'ono, saladi, ndi zina zambiri, ndipo izi zidzakhala zokwanira kuteteza kukwiya kwa mankhwalawa pamimba.

Mapiritsi a Trombo ACC iwo eni ayenera kumezedwa kwathunthu, osaponderezedwa, kutafunidwa, kuphwanyika, kapena kuwonongedwa m'njira ina iliyonse.

Monga lamulo, thrombo ACC imatengedwa kamodzi patsiku lonse. Ndikofunika kumwa mankhwalawa tsiku lililonse nthawi yomweyo - chifukwa mumangofunika kusankha tsiku linalake masana ndikumwa mankhwalawa nthawi ino. Ndikosavuta kuti ambiri atenge Thrombo ACC asanadye chakudya cham'mawa, pomwe ena amakonda kuchita izi madzulo asanagone. Kutenga nthawi kwa mapiritsi kumadalira kwathunthu momwe wodwalayo alili. Koma kumbukirani kuti nthawi iliyonse mukamwa mowa, mukatha kudya chakudya chochepa.

Mapiritsi a Thrombo ACC adapangidwira kuti azitha kugwiritsidwa ntchito kwa nthawi yayitali, ndipo nthawi yeniyeni ya maphunziro a mankhwala ndi omwe adatsimikiza ndi dokotala. Wina amakulamulidwa kupitiliza kwa Thrombo ACC kwa miyezi isanu ndi umodzi kapena ngakhale zaka zingapo, ndipo wina amapatsidwa miyezi itatu yopuma milungu iwiri kapena inayi pakati pawo. Pambuyo pa ntchito, Thrombo ACC ikhoza kukhazikitsidwa kwa mwezi umodzi wokha. Koma kwakukulu, nthawi zambiri Trombo ACC imalembedwa kuti ikhale ndi moyo, chifukwa ngati munthu ali ndi chiopsezo cha thrombosis ndikusokonekera kwa mitsempha yambiri ndi thrombi, ndiye kuti samasowanso ndipo amakhalabe atamwalira. Ndikuteteza kupangika kwa magazi kuundana ndi kufinya kwa mitsempha yamagazi yomwe thrombo ACC imatengedwa kwa nthawi yayitali, pokhapokha, ngati, munthu ali ndi chiopsezo chachikulu cha thrombosis.

Mlingo wa matenda osiyanasiyana

Mlingo wa thrombotic ACC zimatengera chifukwa chomwe mankhwalawa amatengedwa.

Chifukwa chake, kupewa matenda oyamba ndi obwereza am'mnyewa wamtima, Thrombo ACC iyenera kumwedwa 50-100 mg patsiku (1 piritsi 50 mg kapena piritsi limodzi 100 mg kamodzi patsiku).

Mankhwalawa angina osakhazikika komanso osakhazikika, thrombo ACC imalimbikitsidwanso kutenga 50-100 mg patsiku. Chifukwa chake, muyenera kumwa piritsi limodzi la 50 mg kapena 100 mg kamodzi patsiku.

Pofuna kupewa kuwonongeka kwa ma stroke komanso ngozi yochepa ya cerebrovascular, Thrombo ACC tikulimbikitsidwa kutenga 50-100 mg patsiku (1 piritsi 50 mg kapena piritsi limodzi 100 mg kamodzi patsiku).

Kupewera kwa thromboembolism pambuyo pakuchita opaleshoni iliyonse komanso pambuyo pachitetezo cha mtima kumaphatikizapo kutenga Thrombo ACC pa 50 - 100 mg patsiku (piritsi limodzi la 50 mg kapena piritsi limodzi la 100 mg kamodzi patsiku).

Kuti muthane ndi vein thrombosis yakuya ndi thromboembolism ya chotupa cha m'mapapo ndi nthambi zake, Thrombo ACC tikulimbikitsidwa kuti itenge 100-200 mg patsiku (1 kapena 2 mapiritsi a 100 mg kamodzi patsiku).

Gwiritsani ntchito panthawi yoyembekezera komanso poyamwitsa

Kugwiritsa ntchito acetylsalicylic acid m'miyezi itatu yoyambirira ya kubereka kumatha kudzetsa vuto lachitukuko mu fetus, monga kugawanika kwapamwamba ("cleft palate"), zolakwika za mtima, ndi zina zambiri. Ichi ndichifukwa chake kumwa mankhwala okhala ndi acetylsalicylic acid, kuphatikiza Thrombo ACC, kumapangidwanso kwambiri pakatha milungu khumi ndi itatu yapakati.

Kukonzekera acetylsalicylic acid mu Mlingo woposa 300 mg tsiku kuchokera pa sabata la 27 la mimba ndipo musanabadwe kumayambitsa kusokonezeka kwa ntchito, kuchuluka kwa magazi kwa mayi ndi mwana wosabadwayo, komanso kusakhazikika kwa nthawi yotseguka kwa mtima kwa mwana wosabadwayo. Kulandiridwa kwa acetylsalicylic acid musanabadwe kumayambitsa kukhumudwa kwa mwana wakhanda, makamaka ngati mwana wosabadwayo asanabadwe. Ichi ndichifukwa chake kumwa mankhwala aliwonse acetylsalicylic acid wachitatu trimester ya mimba ndizoletsedwa.

Munthawi yachiwiri ya mimba, kuyambira pa 14 mpaka sabata la 26, kuphatikiza, Trombo ACC imangotengedwa pokhapokha pozindikira, pamene ikufunika kwa mayi woyembekezera, ndipo ngati mapindulowo aposa zoopsa zonse zomwe zingachitike. Munthawi yachiwiri ya mimba, kugwiritsa ntchito thrombo ACC pamaphunziro achidule ndizovomerezeka.

Acetylsalicylic acid ndi zotuluka zake zimapita mkaka wa m'mawere. Koma dalaivala mwangozi acetylsalicylic acid nthawi zambiri samayambitsa zovuta kapena zovuta mu makanda, chifukwa chomwe thrombo ACC nthawi yoyamwitsa imaloledwa. Komabe, ngati Trombo ACC yatengedwa kwa nthawi yayitali, ndiye kuti kuyamwitsa kuli bwinoko kuletsa ndikusamutsa mwanayo pazinthu zosakanikirana.

Kuchita ndi mankhwala ena

Thrombotic ACC, ikagwiritsidwa ntchito palimodzi, imapititsa patsogolo zotsatira za mankhwala otsatirawa:

• Methotrexate (utachepa wa methotrexate ndi impso),
• Maanticoagulants (Heparin, Warfarin, etc.), thrombolytics (Urokinase, Fibrinolysin, etc.) ndi othandizira ena antiplatelet (Clopidogrel, Curantil, etc.). Mukamatenga ndi Trombo ACC, zowononga mucous nembanemba zam'mimba ndipo matumbo amawonjezeka, ndipo chiopsezo chotuluka magazi chikuwonjezeka,
• Kusankha serotonin reuptake inhibitors (Fluoxetine, Venlafaxine, Elicea, Valdoxan, Flunisan, Oprah, ndi ena otero) - chiopsezo chotaya magazi kuchokera m'mimba ndi kum'mero ​​kumawonjezera,
• Digoxin - kutulutsa kwake ndi impso kumachepetsedwa, komwe kumatha kutsogola kwake,
• Zotsatira za sulfonylureas kuti muchepetse shuga m'magazi (Glibenclamide, Glycvidone, Glyclazide, Glimepiride, Glipizid, Chlorpropamide, Buformide, Nateglimide, etc.) - mulingo wa glucose ungachepetse kwambiri,
• Kukonzekera kwa Valproic acid (Konvuleks, Depakin, Dipromal, Valparin XP, ndi ena otero) - kawopsedwe a kuchuluka kwa valproate,
• Zakumwa zoledzeretsa ndi zakumwa zoledzeretsa - chiopsezo cha kuwonongeka kwa mucous m'mimba ndi m'matumbo chimawonjezeka, ndipo nthawi yotuluka magazi imakulanso,
• Mankhwala osapatsirana omwe amaletsa kutupa (Diclofenac, Nimesulide, Indomethacin, Meloxicam, etc.) ndi ma salicylates ena (Salofalk, etc.) - chiopsezo chotupa zilonda zam'mimba ndi zilonda zam'mimba za duodenal ndikuwonjezereka kwa magazi.

Kugwiritsa ntchito pamodzi kwa Thrombo ACC ndi mankhwala otsatirawa kumachepetsa mphamvu zawo (chifukwa chake kuwonjezeka kwa mlingo wawo kungakhale kofunikira):

• Mankhwala aliwonse a diuretic (mothandizidwa ndi Thrombo ACC, kuchuluka kwa kusefa kwa mkodzo ndi impso kumachepa),
• Inhibitors a angiotensin-converting enzyme (Captopril, Kapoten, Perineva, Prenessa, Enalapril, ndi ena otero) - zotsatira za zoletsa zochepetsera kuthamanga kwa magazi zimafooka ndipo zotsatira zawo zamtima zimayendetsedwa. Nthawi zambiri, kutsika kwakuya kwa zochita za angiotensin-kutembenuza ma enzyme ma inhibitors kumawonedwa pamene atengedwa limodzi ndi Thrombo ACC mu mlingo wopitilira 160 mg patsiku,
• Mankhwala omwe amalimbikitsa kuphipha kwa uric acid (Probenecid, Benzbromaron) - zotsatira zawo zimachepa chifukwa chakuchepa kwa impso,
• Ma systemic glucocorticoid mahomoni (prednisone, dexamethasone, etc.) - kutulutsa kwa thrombo ACC kumatheka bwino, ndipo zotsatira zawo zimafooka.

Zotsatira zoyipa

Thrombo ACC nthawi zambiri imalekeredwa bwino, ndipo, chifukwa cha kuchuluka kochepa kwa acetylsalicylic acid, sikuyambitsa mavuto. Komabe, nthawi zina, thrombo ACC imatha kupweteketsa zotsatirapo zosiyanasiyana zotsatirazi zosiyanasiyana zamagulu ndi machitidwe osiyanasiyana:

1. Kuchokera m'mimba:

• Kuchepetsa mseru
• Kubweza
• Kutentha kwa mtima
• Kupweteka kwam'mimba
• Zilonda zam'mimba kapena zam'mimba,
• Kutulutsa magazi m'mimba
• Kuwonongeka kwakanthawi kwa chiwindi ndi ntchito yowonjezereka ya aspartate aminotransferase (AcAT) ndi alanine aminotransferase (AlAT).

• Chizungulire
• Kumva kuwonongeka
• Tinnitus.

• Kutulutsa magazi kwambiri nthawi ndi pambuyo pa opareshoni,
• Mapangidwe a hematoma pafupipafupi,
• Pafupipafupi mphuno
• Kutsekemera kwa mano
• Kutuluka magazi kumaliseche
• Churbral hemorrhages (pamakhala chiopsezo chachikulu kwa odwala omwe amatenga Warfarin kapena anticoagulants nthawi yomweyo, kapena osayang'anira kuthamanga kwa magazi, koma nthawi zambiri amakwera).
• Pachimake kapena matenda a posthemorrhagic kapena kuchepa kwazitsulo chifukwa cha kutuluka magazi.

• Zotupa pakhungu
• Khungu loyera
• Urticaria,
• Edincke's edema,
• Thupi lawo siligwirizana
• Kutupa kwa mucosa wammphuno (kuchulukana kwammphuno),
• Bronchospasm (kupatulira mwamphamvu kwa lumen ya bronchi ndi zomwe zimachitika ndi mphamvu yakudziwika),
• Cardio-kupuma nkhawa matenda,
• Kugwedezeka kwa anaphylactic.

Momwe mungatenge thrombo ACC - isanayambe kapena itatha chakudya?

Atapita kwa adotolo, wodwalayo adapeza dzina latsopano la mankhwalawo pamndandanda wololeza. Chotsatira, kawirikawiri, ndemanga yayifupi imamangidwa, ndikuwonetsa kuchuluka kwa mlingo umodzi wa mankhwalawa, womwe umachulukitsidwa ndi kuchuluka kwa Mlingo patsiku. Nthawi zina, izi ndizokwanira, koma pokhapokha ngati mukufunikira kutenga TromboASS.

Zachidziwikire, mutha kuwona momwe mungatengere mapiritsi a Thrombo ACC pakuchepetsa magazi, nthawi zonse pamakhala gawo - "njira yogwiritsira ntchito", yosonyeza nthawi yochita izi musanadye kapena musanadye chakudya. Koma kuti asanyoze ophatikiza, malangizo oterewa amapangidwira nzika wamba yomwe simakhalapo. Kenako, mndandanda wazotsutsana umatsatira, pomwe aliyense amapeza chimodzi mwa “zopweteka” zake.

Pambuyo pake, madandaulo okhudza kusasamala, komanso kunyalanyaza kwa adotolo omwe adakhalapo, ayamba. Makamaka omwe ali ndi "ventricles", ndikudziyimira pawokha osasinthika amitundu yomwe ilibe ma acid.

Ndiye akulakwa ndani? Dokotala? Kapena katswiri yemwe analemba chikondwererocho limodzi ndi mankhwalawo? Yankho likhoza kupezeka pogwiritsira ntchito malangizo omwe ali m'ndime yomwe kapangidwe kake piritsi limodzi amafotokozedwa mwatsatanetsatane.

Zomwe zimaphatikizidwa bwanji pokonzekera thromboass?

Peresenti yayikulu ya mankhwalawa, mwachidziwikire, ndi acetylsalicylic acid. Izi ndi zomwe odwala omwe ali ndi gastritis ndi zilonda zam'mimba sizimalola.

Koma sitiyenera kuiwala kuti, mosiyana ndi ASK wamba yomwe imagulitsidwa ku malo ogulitsira, mapiritsi ochepetsa magazi a TromboAX amakhala atakulungidwa ndi chipolopolo pomwe zigawo monga talc ndi eudragit zilipo.

sc name = "info2 ″ text =" Mu kuchuluka kwa talc, komwe ndi gawo la chigobacho, pali magnesium - chinthu chomwe chimalepheretsa kuwonongeka kwa ASA pa epithelium yam'mimba. "

Maudzu otengedwa ndi ma polymerization a acrylic acid. Amagwira ntchito zonyamula mankhwalawo kumalo ena ake amkati, amawateteza ku zotsatira za m'mimba acid komanso kuyamwa msanga.

Komabe, kugogomezera kwa contraindication ndikofunikira. Ichi ndi "chochitika chotsimikizika" pomwe wodwala, atasowa, "osakhala pamimba yopanda kanthu" komanso "osafuna kutafuna", amawoloka "mosamala" ndipo "osavomerezeka."

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mapiritsi a enteric-wokutidwa wa thrombopol, opinki mu utoto, ali ndi chophatikizira chomwe chimatchedwa Acidum acetylsalicylicum. Malinga ndi ndemanga ya Trombopol, mankhwala owoneka mozungulira amaperekedwa muyezo wotsatirawu - ma milligram makumi asanu ndi awiri mphambu zana limodzi kudza makumi asanu. Monga zosakaniza zothandizira, wopangayo amagwiritsa ntchito wowuma chimanga, MCC, atria amylopectin glycolate. Chipolopolocho chili ndi zigawo zingapo - Hypromellosum, kaphatikizidwe kaphatikizidwe kaphatikizidwe ka mankhwalawa ndi E553b, chakudya chowonjezera E171, triethyl citrate, utoto, Silicii dioxydum colloidale, Natrii hydrocarbonas, sodium lauryl sulfate. Mtengo wamba wa Trombopol ndi ma ruble 51. Zambiri zakupezeka kwa mankhwalawa zitha kupezeka pafoni kapena pa webusayiti ya omwe amagulitsa.

Popeza tayang'ana pansi pa chipolopolo, mutha kuwona kuti kuphatikiza pa ACS, zinthu zomwe zimagwira ndikuphatikizira:

• lactose
• cellulose
• silicon
• wowuma mbatata.

Lactose amapanga malo osungira lactobacilli, kukulitsa kapangidwe ka microflora yamatumbo. Ma cellulose amayeretsa matumbo a poizoni. Silicon amamanga ndikuchotsa bilirubin m'thupi, mwakutero amawonda magazi. Mbatata wowuma amachepetsa acidity ndikuwonjezera chitetezo chokwanira.

sc name = "info2 ″ text =" Mwachilengedwe, zomwe zili mu piritsi limodzi ndizochepa. Koma powona kuti mankhwalawo ndi mankhwala, kwa nthawi yayitali, amafunikira mobwerezabwereza ndipo afunikira kale. ”

Popeza tinafotokozera cholinga cha zigawo zonse za mankhwalawo, tikubwerera ku funso lalikulu. Momwe mungasungire thromboass, ndipo ndikofunikira kuti mutenge mapiritsi - musanadye kapena mutatha kudya?

Kodi kuchepa mphamvu kwa mapiritsi kumadalira kuchuluka, kuchuluka ndi nthawi ya chakudya?

Kafukufuku wachitika pankhaniyi awonetsa:

1. Gawo lalikulu la ASA limalowa m'matumbo aang'ono, kapena, m'malo ake apamwamba.
2. Nthawi ya mayamwidwe sikudalira kuchuluka kwa m'mimba.
3. Maantacidids omwe amachepetsa acidity ya madzi a m'mimba samakhudza kuthamanga kwa thupi kukonzekera kwa mankhwalawa. Zomwezi zitha kunenedwa za mkaka ndi zinthu zina zomwe zimakhala ndi mafuta a nyama.

Apanso, timatembenukira ku malangizo, pomwe akuti mapiritsi a Thrombo ACC ayenera kumwedwa musanadye, koma osati pamimba yopanda kanthu. Ndi kuti chakudya sichisokoneza ntchito ya mankhwala, osankhidwa.

Ndikumvetsetsa kuti zomwe sizikhala pamimba yopanda tanthauzo zimatanthawuza chiyani?

Osamamwa mapiritsi atangotha ​​kugona. Mimba imafunanso nthawi kuti ichitike. Ngati, pazifukwa zina, theka loyamba la tsiku ndilo njira yabwino kwambiri yothira mankhwala, ndiye kuti muyenera kudya kaye kena. Lolani kuti ikhale chakudya chocheperako, koma chimapereka m'mimba monga lamulo - "kuyamba".

Mankhwala otupa chifukwa cha magazi ochepa thupi, otengedwa "m'mimba yopendekeka," osadya pambuyo pake, amakhala pachiwopsezo chosungunuka m'mimba. Ndi acidity yowonjezereka kwachilengedwe, gawo lalikulu la ASA lidzakhalabe mu yankho la asidi, kukulitsa kukhumudwitsa kwamaselo a epithelial. Ndi acidity ya m'mimba yotsika, ASA imayilowetsedwa m'makoma a chimba m'mimba ndipo imadziunjikira mu ma cell a mucous membrane, omwe si ofunika konse.

sc name = "info" text = "Muyenera kutenga Tromboass pamalo apakatikati, zomwe sizinganene kuti ndi" mutatha kudya ", kapena" kale. "

Momwe mungathe kumvetsetsa, njira izi zonse zimaphatikizidwa, makamaka, kutetezedwa kwa dongosolo logaya chakudya, ku zotsatira zoyipa za ASA, ndipo musakhudze kuwonda kwa mankhwalawa.

Kodi woponda magazi amagwira ntchito bwanji?

Zosakhazikika m'makoma am'matumbo aang'ono, zinthu zomwe zimagwiritsa ntchito mankhwalawo zimalowa m'magazi ndikugwirizana ndi mapuloteni ake. ASA imadziwika ndi kuyika kunja kwa maselo. Komanso kuphatikizidwa ndi mapuloteni, sataya ntchito yake.

ASA imalowerera thromboxane - enzyme yotulutsidwa ndi ma cellulo ophatikizika, omwe amagwiritsa ntchito ngati chizindikiritso cha mapulateleti ena. Mapulatata ophatikizidwa, mpaka kumapeto kwa moyo wawo, amatha kulephera, zomwe zimathandiza kuwonda magazi.

Chosangalatsa ndichuma cha ASA chomwe chili mu mankhwalawa ndikuti mankhwalawa sangapezeke konse m'madzi a m'magazi (kapena kupezeka pang'ono). Koma, komabe, mphamvu ya inhibitory pa ntchito ya mapulateleti idzawonetsedwa bwino.

sc name = "info" text = "Kupukusidwa m'maselo a chiwindi, ASA imayika" wobisalira "pamapulateleti pano. "Dongosolo lozungulira limawanyamula pano, komwe amadziwitsidwa ndi mlingo wonse wa mankhwalawo."

Poyerekeza ndi kuchepa kwa kuchuluka kwa thromboxane, zomwe zili mu uhule, zomwe ndi zotsutsana ndi puloteni yotulutsa magazi, zimatuluka m'magazi. Chifukwa chake, zoyenera komanso zoyembekezeredwa zimatheka - kupatulira magazi.

Popeza tikulimbikitsidwa kutenga Thrombo ACC kuti muchepetse magazi, kutsuka mapiritsi ndi madzi ambiri kapena madzi aliwonse, izi zimazindikira nthawi yoyenera - musanadye, osati pambuyo pake. Chakudya, chomwe chimakhala ndi madzi ambiri, chimapangira ntchito m'mimba ndipo chimakhala mkati mwake kwa nthawi yayitali.

Monga lamulo, adotolo amakupereka mlingo umodzi wa mankhwalawa, ndikulimbikitsidwa kwamadzulo. Mwanjira imeneyi, munthu sayenera kuyang'ana kudalira kobisika kwa thupi kapena zifukwa zina.

Mphindi yamadzulo, musanadye chakudya chamadzulo, ndizofunikira kwambiri kuchokera pamaganizidwe. Iyi ndi nthawi yomwe masana nkhawa, kuthamanga, zachabe zatha. Thupi, kuphatikiza ubongo, limalandira nthawi yayifupi yochotsa nkhawa zakunja ndipo limatha kudziyang'ana lokha. Umu ndi malo abwino omwera mapiritsi molondola.

sc name = "info2 ″ text =" Malinga kuti zigwiritsidwe zonse zimawonedwa, mankhwalawo sangangokhala ndi zovuta m'mthupi, koma zinthu zonse zowola zimachotsedwa bwino. "

Ngati wodwala akukayikira kufunika kwa mankhwalawa. Ngati munthawi ya chithandizo zizindikiro zopweteka zimawoneka m'mimba, nseru, chizungulire, kuchepa mphamvu. Muyenera kulumikizana ndi dokotala wanu nthawi yomweyo.

Mulimonsemo, simuyenera kusintha paokha Mlingo wa mankhwalawo kapena kulowererani mwa SupomboASS ndi analogues. Uku ndikofunikira kwa akatswiri omwe ali ndi chidziwitso chokhudza momwe thupi la wodwalayo lilili, lopangidwa motsatira mayeso ndi kusanthula, poganizira zofunikira zonse zomwe zingachitike.

Zotsatira za pharmacological

Kafukufuku wachipatala awonetsa kuti, monga mawonekedwe ake, thrombopol imatengedwa mwachangu kuchokera mumimba. Acidum acetylsalicylicum ali ndi chuma chosinthidwa kukhala phenolic acid. Kuchuluka kwa acetylsalicylic acid m'madzi am'magazi adalembedwa pafupifupi mphindi khumi ndi zisanu atatha kumwa mankhwalawa, metabolite yogwira imafika pazigawo zambiri mkati mwa mphindi makumi atatu ndi zana limodzi. Chifukwa cha kukhazikika kwa chipolopolo cha piritsi, kumasulidwa kwa mankhwala omwe amagwira ntchito amapezeka m'matumbo. Katunduyu amathandizira kuti muchepetse kuyamwa kwazinthu zogwira ntchito - kuyambira 180 mpaka 360 mphindi. Zonsezi zomwe zimagwira komanso metabolite yogwira ntchito imatha kukhala ndi mapuloteni a plasma. Komanso, zinthu zomwe zalembedwazo zimadziwika ndi kugawa mwachangu mu minofu. 2-hydroxybenzoic acid ili ndi mwayi wopezedwa mu mkaka wa m'mawere. Zotsatira za zoyesazo zinaonetsa kuti metabolite imalowa mkati mwa chotchinga cha placental. Kutulutsa kwake kumadalira mlingo womwe waperekedwa. Ndi kuchuluka kochepa kwa mankhwalawa, theka la moyo limatenga 120 mpaka 180 maminiti. Pa mlingo waukulu, T1 / 2 ndi maola khumi ndi asanu. Kutupa kwa salicylic acid kumachitika makamaka kudzera mu impso. Mutha kuyitanitsa thrombopol kutali. Gawo logwira ntchito limakhala ndi zinthu izi: • linalake ndipo tikulephera kuphatikizika kwa mapulogalamu am'magazi; Palinso malingaliro a njira zina zochitira Acidum acetylsalicylicum pakuphatikizana kwa mapulateleti, motero thunthu limagwiritsidwa ntchito mwachangu pochiza matenda osiyanasiyana a mtima. NSAIDs ndi ena mwa iwo, ndipo acetylsalicylic acid ali ndi zovuta: • amathandizira kupweteka, • amachepetsa kutentha, • amachotsa kutupa. Mafuta ambiri omwe amagwira ntchito, monga momwe afotokozedwera, amagwiritsidwa ntchito kupweteka kwamatenda opatsirana ndi ma virus, komanso fuluwenza yoletsa kusintha zotsatirazi: ndi ankylosing spondylitis.

Thrombopol, monga momwe malangizowa akunenedwera, amalembedwa kwa odwala omwe ali ndi matenda otsatirawa: Chimodzi mwazinthu zoyambitsa - matenda ashuga, kuthamanga kwa magazi, zizolowezi zoipa, kuphatikizapo kusuta, kwa odwala okalamba (kuyambira azaka 65), dyslipidemia, milandu yobwereza MI, • prolact akuti ka pachimake blockage wa magazi chotengera ndi thrombus, kuti kusiya malo awo a maphunziro, makamaka opaleshoni kapena olanda mtima, embolism m'mapapo mwanga • Kupewa, • kupewa matenda pachimake-isanayambike mu ubongo ntchito ya chiyambi mtima, akuwonetseredwa focal oziziritsa kapena wosanganiza zizindikiro.

Mlingo ndi makonzedwe

Trombopol ndi yogwiritsa ntchito pakamwa. Wopangayo amalimbikitsa kumwa mankhwalawa pambuyo podyera, osawononga umphumphu wake. Mlingo, komanso njira yothandizira mankhwalawo, zimatsimikizika malinga ndi mbiri ya wodwalayo komanso kuopsa kwa matendawa: 1. Ngati wina akuganiza kuti MI ali pachimake, kuyambira mamiliyoni zana limodzi ndi makumi asanu ndi atatu mpaka atatu pazomwe zimagwira. Wopanga amalimbikitsa kutafuna piritsi loyambalo ngati zizindikiritsa zoyamba. Kuphwanya membrane wa enteric kumathandizira mphamvu ya mankhwalawa. Pakupita kwa mwezi wotsatira, odwala ayenera kutenga 75 mpaka 300 milligrams patsiku. Pambuyo pa njira yochiritsira, dokotala wopezekapo ayenera kuganizira kufunika kwa mankhwalawa, kuti apewe matenda atsopano. 2. Kwa odwala omwe adachitapo MI, kuti muchepetse vuto la kuchepa mphamvu, komanso zotulukapo zakupha, kuchuluka kwa mankhwalawa kumayikidwa mgulu la ma milligram 75 7500. 3. Ndi mankhwala otchedwa angina pectoris a mtundu wokhazikika komanso wosakhazikika, mudzafunika kuchokera ku ma milligram makumi asanu ndi awiri mphambu asanu mpaka atatu a chinthu chogwira ntchito patsiku. 4. Odwala omwe ali pachiwopsezo chotukuka kwa zizindikiro za MI mu mawonekedwe owopsa ndi matenda ashuga, kuthamanga kwa magazi, kunenepa kwambiri, komanso okalamba akulimbikitsidwa kutenga mamiligirama zana limodzi ndi makumi asanu a ntchito tsiku lililonse kapena ma milligram mazana atatu tsiku lililonse. 5. Popewa kukula kwachiwiri kwa matenda opha ziwalo, mufunika kuchokera pa makumi asanu ndi awiri mphambu asanu mpaka atatu a milligram a chinthu chogwira ntchito masana. 6. Mlingo wofanana tsiku ndi tsiku umagwiritsidwa ntchito pochiza odwala omwe ali ndi vuto la kuchepa kwa ischemic, komanso ngati ali ndi vuto la stroke komanso ngati prophylaxis chifukwa chotupa chamtsempha wamagazi ndi thrombus yochoka pakapangidwe kake pambuyo pakuchita opaleshoni ndi njira zowukira. 7. Mutha kuletsa DVT ndi thromboembolism ndi Trombopol pa mlingo wa 75 mpaka 200 milligrams patsiku. Njira inanso yamankhwala imaloledwa, kugwiritsa ntchito mamiligalamu mazana atatu tsiku lililonse. Perekani, monga lamulo, pambuyo pa opaleshoni yayikulu. Odwala omwe ali ndi vuto la impso ndi chiwindi chofatsa komanso zolimbitsa, kusintha kwa mankhwala kungafunike.Mutha kugula Trombopol pamasitolo ogulitsa ma pharmacies ndi ma intaneti.