The mankhwala Farmasulin: malangizo ntchito

Farmasulin® N NP ndi Farmasulin® N 30/70 ndi kukonzekera kwa insulin yaumunthu yomwe imapezeka pogwiritsa ntchito ukadaulo wa DNA. Yotsirizira ili ndi zinthu zonse zomwe zimakhala ndi insulin. Mankhwala amapereka makamaka kagayidwe kazakudya minofu. Chepetsani shuga. Amathandizira kupititsa patsogolo kayendedwe kogwiritsa ntchito ma carbohydrate ndi ma amino acid mu malo amkati, kupondereza lipolysis, kulimbikitsa kapangidwe ka RNA ndi mapuloteni, komanso kuyambitsa kaphatikizidwe ka glycogen. Mankhwalawa amachulukitsa potaziyamu kulowa m'maselo kuchokera kumalo a pericellular, omwe amathandizira kuchepetsa kuchuluka kwa diastolic myocardial depolarization yomwe imachitika ndi mtima komanso monga mbali yotsatira mukamagwiritsa ntchito digitis, GCS ndi catecholamines.
Kukhazikika kwa mphamvu ndi ola limodzi pambuyo pa kutumizidwa kwa Farmasulin® N NP kapena mphindi 30 pambuyo pa kuperekedwa kwa Farmasulin® H 30/70. Chiwopsezo chokwanira kwambiri ndi chothandizira chimawonedwa pakati pa maola 2 ndi 8 mukamagwiritsa ntchito Farmasulin® N NP kapena pakati pa 1 ndi 8.5 maola mukamagwiritsa ntchito Farmasulin® H 30/70. Kutalika kwa kukhalanso achire ndende ndi maola 18 - 20 kapena 14 mpaka 14, motero.

Zisonyezero zakugwiritsa ntchito mankhwala a Farmasulin

Insulin-wodwala matenda a shuga a mellitus (mtundu I), osachiritsika omwe amadalira matenda a shuga (mtundu II), ngati sizotheka kukwaniritsa chipukutiro cha matendawa ndi zakudya komanso mankhwala a pakamwa a hypoglycemic. Matenda amtundu uliwonse a shuga ophatikizidwa ndi matenda, matenda osakhazikika a pakhungu, zilonda zam'mimba, kuchepa kwa mtima, kuperewera kwa mtima, maopaleshoni odwala omwe ali ndi matenda ashuga, matenda ashuga a ketoacidosis, precoma ndi chikomokere, kukana kukonzekera kwa sulfonylurea matenda ashuga.

Kugwiritsa ntchito mankhwala Farmasulin

P / c. Mlingo ndi nthawi yoyang'anira imayikidwa payekhapayekha kwa wodwala aliyense. Mankhwalawa amaperekedwa 1 kapena kangapo patsiku. Mlingo pakati pa jakisoni wa SC ndikudya kwa chakudya sikuyenera kupitirira mphindi 45-60 (osapitirira mphindi 30 mukamagwiritsa ntchito Farmasulin® N 30/70). Kugwiritsa ntchito mankhwalawa kuyenera kutsagana ndi chakudya chovomerezeka. Posankha zakudya zopatsa mphamvu (monga lamulo, zopangira 1700-3000), ndikofunikira kuwongoleredwa ndi kulemera kwa thupi la wodwalayo, komanso chikhalidwe cha zomwe akuchita. Posankha mtundu woyenera wa mankhwalawa, ndikofunikira kutsogoleredwa ndi msana wa kusala kudya kwa glycemia komanso masana, komanso kuchuluka kwa glucosuria masana. Pakuwerengera kwamawerengero a mankhwala, munthu akhoza kutsogoleredwa ndi izi: ngati glycemia ikuchuluka kuposa 9 mmol / L, 2- IU ya insulini imafunikira kuti pakhale kusintha kwa glucose aliyense wotsatira 0,45-0.9 mmol / L wamagazi. Kusankhidwa komaliza kwa mlingo wa insulin kumachitika motsogozedwa ndi zomwe zimachitika wodwalayo ndikumaganizira glucosuria ndi glycemia, omwe amawonedwa motsutsana ndi magwiritsidwe ntchito a mankhwalawa. Childs, tsiku lililonse mlingo wa mankhwalawa ndi 0,5-1.0 IU / kg kulemera kwa thupi mwa akulu ndipo sayenera kupitirira 0.7 IU / kg kulemera kwa ana. Odwala omwe ali ndi vuto la matendawa pa nthawi yomwe ali ndi pakati, mwa ana - kusintha kwa mankhwala a insulin sikuyenera kupitirira 2I IU pa 1 jakisoni.
Kubaya
Muyenera kudziwa kuti syringe imagwiritsidwa ntchito, kumaliza kwake komwe kumafanana ndi kuchuluka kwa insulin. Syringe ya mtundu womwewo ndi chizindikiro chikuyenera kugwiritsidwa ntchito. Kupanda chidwi mukamagwiritsa ntchito syringe kungayambitse Mlingo wa insulin yolakwika. Jakisoni ukuchitika motere:

Musanatolere insulini kuchokera ku vial, muyenera kudziwa zomwe zili mkati mwake. Pankhani yanyansi kapena mawonekedwe a mtundu wapamwamba mutatha kukonza zomwe zili pamalopo, mankhwalawa sayenera kugwiritsidwa ntchito. Atangobayira jekeseni, vial yoyimitsayo imakulungidwa pakati pa manja kuti mpweya wake mkati mwake ukhale wofanana.
Insulin imatengedwa kuchokera pamtondo ndikuboola ndi singano yosalala ya cork yomwe inali yozikika kale ndi mowa kapena mowa wa ayodini. Kutentha kwa insulin yoyenera kuyenera kukhala kutentha kwambiri.
Ngati mtundu umodzi wa insulin ndi womwe ukugwiritsidwa ntchito, ndiye kuti:
- mpweya umakokedwa kulowa mu syringe ku mtengo womwe umalingana ndi kuchuluka kwa insulin, ndipo pambuyo pake mpweya umatsitsidwa mu vial.
- syringe ndi vial yatembenuzidwira kuti vial itembenuke mozondoka ndikufunika ndi insulin.
- singano imachotsedwa pambale. Syringe imamasulidwa kuchokera kumlengalenga ndipo kulondola kwa mlingo wa insulin kumayendera.
Ngati mitundu iwiri ya insulini isakanikirana, ndiye kuti musanabayitsa jakisoni ndi kuyimitsidwa kwa insulini (solution ya turbid) imakulungidwa pakati pa manja kuti mpweya wake wonse ukhale wokwanira. Mpweya wamagetsi umakokedwa mu syringe yomwe ikufanana ndi kuchuluka kwa kuyimitsidwa kwa insulin, ndipo mpweya uwu umalowetsedwa mu vial ndi kuyimitsidwa kwa insulin. Chotsani singano m'botolo. Apanso, mpweya umakokedwa mu syringe ku mtengo womwe umafunikira wa yankho la insulin. Lowani mpweya uwu mumabotolo okhala ndi yankho la insulin. Syringe ndi vial imatembenuzidwira kuti vial imayandikira ndipo njira yofunikira yothetsera insulin yowonekera imasonkhanitsidwa. Chotsani mpweya mu syringe ndikuwunika kulondola kwa njira ya insulin. Singano imalowetsedwanso mu vial ndi kuyimitsidwa kwa insulin ndipo mlingo womwe wapatsidwa umasonkhanitsidwa. Chotsani mpweya mu syringe ndikuyang'ana mlingo woyenera. Nthawi zonse ndikofunikira kuyika insulin mwanjira yomwe ikuwonetsedwa. Izi zimatsimikizira kusakaniza kwofananira kwa osakaniza mu syringe. Atangomaliza kugwira ntchito pamwambapa, jakisoni amapangidwa.
Wogwira khungu pakati pa zala, jekesani singano m'khola la khungu pakatikati pa 45 ° ndikujambulira insulin s / c.
Singano imachotsedwa ndipo tsamba la jakisoni limakanikizidwa pang'ono kwa masekondi angapo kuti muchepetse kutuluka kwa insulin.
Akufuna kusintha tsamba la jakisoni.

Zotsatira zoyipa za mankhwala Pharmasulin

Pafupipafupi - lipodystrophy, insulin kukana, hypersensitivity zimachitikira. Ndi insulin yotalika kwa mankhwala a jakisoni, magawo a atrophy kapena hypertrophy a subcutaneous fat layer angawonedwe. Izi zimatha kupewa chifukwa chosintha jakisoni nthawi zonse. Ngati pali zovuta zina zomwe zimakhudzana ndi mitundu ina ya insulini m'mbiri ya wodwala, mankhwalawa amawayikidwa atalandira mayeso olakwika a intradermal. Ngati thupi siligwirizana, ndikofunikira kusamutsa wodwala kupita ku mtundu wina wa insulin ndikumupatsa mankhwala othana ndi matupi awo. Panthawi yochita kupatsa insulin kwambiri kapena kudumphadumpha chakudya, komanso kuchita masewera olimbitsa thupi, mungayambitse insulini. Hypoglycemia yamphamvu yosasinthika imatha kukhala ndi mowa ndi wodwala yemwe ali ndi matenda ashuga. Ngati kuchuluka kwa shuga m'magazi kumasungidwa kwambiri, matenda a shuga a ketoacidosis amachitika. Vuto lalikulu lotere limatha kukhalapo ngati wodwala alandira insulini yocheperako kuposa momwe amafunikira. Izi zitha kuchitika chifukwa cha kuchuluka kwa insulin panthawi yakudwala, kuphwanya zakudya, kusakhazikika kwa insulini kapena insulin yokwanira. Kukula kwa ketoacidosis kumatha kupezeka ndikuwunika mkodzo, momwe mumapezeka zinthu zambiri zamatenda a shuga ndi ketone. Pang'onopang'ono, nthawi zambiri pakatha maola angapo kapena masiku, zizindikiro zimawoneka ngati ludzu, kuchuluka kwa thupi, kuchepa kwa chakudya, kutopa, khungu louma, kupumira kwambiri komanso kuthamanga. Ngati wodwala amene ali ndi matendawa sanalandiridwe mankhwala, ndiye kuti wodwala matenda ashuga amakula ndi zotsatira zakupha.

Malangizo apadera ogwiritsira ntchito mankhwala Farmasulin

Pa mlingo wa 4 - 4 IU, kawiri pa tsiku, mankhwalawa angagwiritsidwe ntchito ngati mankhwala a anabolic pofowoka kwathupi la thupi, furunculosis, thyrotooticosis, atony pamimba, matenda a chiwindi, komanso mitundu yoyambilira ya matenda a cirrhosis. Muzochita zamisala, amapatsidwa mankhwala othandizira olimbitsa. Ntchito mankhwalawa odwala matenda ashuga, opaleshoni.

Mapulogalamu a mankhwala a Pharmaculin

Glucagon, diazoxide, phenothiazine zotumphukira, thiazide okodzetsa, corticosteroids, mahomoni a chithokomiro, kulera kwapakhomo kwa mahomoni kumafooketsa mphamvu ya hypoglycemic ya insulin. Kuwonjezeka kwa zovuta za hypoglycemic ya mahomoni ndikotheka ndi kuperekera nthawi imodzi kwa salicylates, guanethidine, Mao inhibitors, oxytetracycline, ndi anabolic steroids. Insulin imawonjezera mphamvu yotsutsana ndi chifuwa chachikulu cha PASK. Insulin ndi strophanthin ali ndi zotsutsana zonse pazochitika za contractile ndi myocardial metabolism, chifukwa chomwe kufooketsa kapena kupotoza zotsatira zawo ndizotheka. Mankhwalawa ndi insulin, makonzedwe a anaprilin asanayambike angayambitse hypoglycemia wa nthawi yayitali. Mowa nawonso umawonjezera chiopsezo cha hypoglycemia.

Mankhwala osokoneza bongo a pharmasulin, zizindikiro ndi chithandizo

Ndi mtheradi komanso wachibale. Zimayambitsa kwambiri hypoglycemic effect. Kuperewera kwa chakudya mokwanira (kusowa kwa chakudya pambuyo pa jekeseni wa insulin), kuchita masewera olimbitsa thupi mopitirira muyeso komanso mowa kumathandizira kuti pakhalepo. Makamaka zimatha kuchitika ndi zovuta matenda, okalamba odwala, ndi vuto laimpso. Zowonetsedwa bwino ndi thukuta, kunjenjemera ndi zochita zina zomasuka, kulephera kudziwa msanga. Chithandizo chimakhala pakudya msanga shuga mkati (koyambirira kwa hypoglycemia). Popewa hypoglycemia, wodwalayo amapatsidwa tiyi wokoma kapena ma shuga ochepa. Ngati ndi kotheka, jekeseni wa iv ya 40% ya glucose ikuchitika kudzera m'mitsempha kapena 1 mg ya glucagon imathandizira. Wodwalayo akapanda kupuma pambuyo pakuwonjezera shuga m'magazi, ndikofunikira kupaka mannitol kapena mlingo waukulu wa corticosteroids kuteteza matenda a edema.

Kusunga mankhwala a Farmasulin

Pamalo amdima pa kutentha kwa 2-8 ° С. Insulin siyenera kuzizira kapena kuwonekera padzuwa! Vial ya insulin yomwe imagwiritsidwa ntchito ikhoza kusungidwa kutentha kwa firiji (mpaka 25 ° C) kwa milungu 6. Pankhani yanyansi kapena mawonekedwe a mtundu wapamwamba mutatha kukonza zomwe zili pamalopo, mankhwalawa sayenera kugwiritsidwa ntchito.

Dzinalo:

Farmasulin (Farmasulin)

1 ml ya Farmasulin N yankho lili ndi:
Insulin ya biosynthetic ya anthu (yopangidwa ndi ukadaulo wa DNA recombinant) - 100 IU,
Zosakaniza zina.

1 ml ya Pharmasulin H NP kuyimitsidwa ili ndi:
Insulin ya biosynthetic ya anthu (yopangidwa ndi ukadaulo wa DNA recombinant) - 100 IU,
Zosakaniza zina.

1 ml ya kuyimitsidwa kwa Farmasulin H 30/70 muli:
Insulin ya biosynthetic ya anthu (yopangidwa ndi ukadaulo wa DNA recombinant) - 100 IU,
Zosakaniza zina.

Zotsatira za pharmacological

Farmasulin ndi mankhwala okhala ndi tanthauzo la hypoglycemic. Farmasulin imakhala ndi insulini, chinthu chomwe chimayendetsa kagayidwe ka glucose. Kuphatikiza pa kuwongolera kagayidwe ka glucose, insulin imakhudzanso njira zingapo za anabolic komanso anti-catabolic mu zimakhala. Insulin imathandizira kaphatikizidwe ka glycogen, glycerin, mapuloteni ndi mafuta achilengedwe m'matumbo am'mimba, komanso kumawonjezera kuyamwa kwa amino acid komanso kumachepetsa glycogenolysis, ketogeneis, neoglucogeneis, lipolysis ndi catabolism ya mapuloteni ndi ma amino acid.
Farmasulin N ndi mankhwala okhala ndi insulin. Muli insulin yaumunthu yomwe imapangidwa ndi tekinoloje ya DNA. The achire zotsatira zimadziwika mphindi 30 pambuyo subcutaneous makonzedwe ndipo kumatenga maola 5-7. Peas ya plasma ndende imafikiridwa patangotha maola atatu pambuyo poti jekeseni.

Mukamagwiritsa ntchito mankhwala a Farmasulin H NP, kuchuluka kwa plasma yogwira ntchito kumawonedwa pambuyo pa maola 2-8. The achire zotsatira amakula mkati 60 mphindi pambuyo makonzedwe ndipo kumatenga kwa maola 18-24.
Mukamagwiritsa ntchito mankhwala a Farmasulin N 30/70, mankhwalawa amakula mkati mwa mphindi 30-60 ndipo amatha kwa maola 14 mpaka 15, mwa odwala ena mpaka maola 24. Chiwonetsero chachikulu cha plasma cha zigawo zikuluzikulu chimawonedwa pambuyo pa maola 1-8,5 pambuyo pa kutsata.

Njira yogwiritsira ntchito

Farmasulin N:
Mankhwala anaupanga subcutaneous ndi mtsempha wa magazi makonzedwe. Kuphatikiza apo, yankho limatha kutumikiridwa kudzera mu intramuscularly, ngakhale subcutaneous ndi intravenous makonzedwe ndikofunikira. Mlingo ndi dongosolo la makonzedwe a mankhwala a Farmasulin N amatsimikiza ndi dokotala, poganizira zosowa za wodwala aliyense. Pang'onopang'ono, mankhwalawa amalimbikitsidwa kuti aperekedwe paphewa, ntchafu, matako kapena pamimba. Pamalo omwewo, jakisoni amalimbikitsidwanso nthawi 1 pamwezi. Mukabayidwa, pewani kupeza njira yothetsera vutoli. Osatupa malo a jakisoni.

Njira yothetsera jakisoni m'matotolo ndi cholinga choti agwiritse ntchito cholembera cholembedwa "CE". Amaloledwa kugwiritsa ntchito yankho lomveka bwino, lopanda utoto lomwe lilibe tizinthu tooneka. Ngati kuli kofunikira kupangira ma insulin angapo, izi ziyenera kuchitika pogwiritsa ntchito zolembera zosiyanasiyana. Za njira yobweretsera cartridge, monga lamulo, chidziwitso chimaperekedwa mu malangizo a cholembera.

Ndi kuyambitsa yankho mu mbale, syringes ikuyenera kugwiritsidwa ntchito, kumaliza kwake komwe kumafanana ndi mtundu wa insulin. Ndikulimbikitsidwa kuti ma syringe a kampani yomweyo ndikulemba agwiritsidwe ntchito popereka yankho la Pharmasulin N, popeza kugwiritsa ntchito ma syringe ena kungayambitse dosing yolakwika. Njira yokhayo yomveka, yopanda utoto yomwe ilibe ma particles owoneka ndi yomwe imaloledwa. Kubaya kuyenera kuchitidwa pansi aseptic. Njira yothetsera kutentha kwa chipinda imalimbikitsa. Kuti mujambule yankho mu syringe, choyamba muyenera kukokera mpweya mu syringe ku chizindikiro chogwirizana ndi kuchuluka kwa insulin, ikani singano mu vial ndi magazi owunda. Pambuyo pake, botolo limasulidwira mozungulira ndipo gawo lofunikira la yankho limasonkhanitsidwa. Ngati kuli kofunikira kupangira ma insulin osiyanasiyana, syringe ndi singano yosiyanasiyana imagwiritsidwa ntchito iliyonse.

Farmasulin H NP ndi Farmasulin H 30/70:
Farmasulin H 30/70 - njira yosakanizika yopanga mayankho Farmasulin N ndi Farmasulin H NP, yomwe imakulolani kuti mulowe ma insulini osiyanasiyana popanda kudzipangira nokha kukonzekera kwa insulin.

Farmasulin H NP ndi Farmasulin H 30/70 amawerengedwa mosatsatira malamulo aseptic. Jekeseni wofunda umapangidwa m'khosi, matako, ntchafu kapena pamimba, komabe, muyenera kukumbukira kuti pamalo omwewo jekeseni sayenera kuchitanso nthawi 1 mwezi. Pewani kulumikizana ndi yankho panthawi ya jakisoni. Amaloledwa kugwiritsira ntchito yankho lokha lomwe pakugwedeza palibe mapepala kapena matope amapezeka pamakoma a vial. Musanayambe kuyendetsa, gwedezani botolo m'manja mwanu mpaka kuyimitsidwa koyenera kukhazikike. Sizoletsedwa kugwedeza botolo, chifukwa izi zimatha kubweretsa kupangika kwa thovu ndi zovuta ndi kukhazikitsidwa kwa mlingo wofanana. Ingogwiritsani ntchito ma syringes ndi maphunziro omaliza muyezo wa insulin. The pakati pakati pa mankhwala ndi kudya zakudya sayenera zosaposa mphindi 45-60 kwa mankhwala Farmasulin H NP ndipo osaposa mphindi 30 kwa mankhwala Farmasulin H 30/70.

Pogwiritsa ntchito mankhwala a Farmasulin, zakudya ziyenera kutsatiridwa.
Kuti mudziwe mlingo, msambo wa glycemia ndi glucosuria masana komanso msanga wa kudya glycemia uyenera kukumbukiridwa.
Kuti muyike kuyimitsidwa mu syringe, choyamba muyenera kukokera mpweya mu syringe ku chizindikiro chomwe chikufunikira mlingo, kenako ndikuyika singano mu vial ndi magazi owunda. Kenako, tembenuzani botolo moyang'ana ndikusonkha kuchuluka koyimitsidwa.

Pharmasulin iyenera kuperekedwa pogwira khungu pakulupika pakati pa zala ndikuyika singano pakona madigiri 45. Popewa kutuluka kwa insulin pambuyo pa kuyimitsidwa, malo omwe jakisoni iyenera kupanikizidwa pang'ono. Sizoletsedwa kupaka jakisoni wa insulin.
Kusintha kulikonse, kuphatikiza mawonekedwe a kumasulidwa, mtundu ndi mtundu wa insulin, kumafunikira woyang'anira.

Zotsatira zoyipa

Munthawi ya mankhwala ndi Pharmasulin, zotsatira zoyipa kwambiri zinali hypoglycemia, zomwe zimapangitsa kuti musakhale chikumbumtima ndi kufa. Nthawi zambiri, hypoglycemia inali chifukwa chodumphira zakudya, kupereka mankhwala ambiri a insulin kapena kupsinjika mopitirira muyeso, komanso kumwa mowa. Popewa kukula kwa hypoglycemia, zakudya zomwe ziyenera kutsatiridwa ziyenera kutsatiridwa ndipo mankhwalawa amayenera kuperekedwa mosamalitsa malinga ndi malingaliro a dokotala.

Kuphatikiza apo, makamaka ndi kugwiritsa ntchito mankhwala kwa nthawi yayitali Farmasulin, kukulitsa kwa insulin kukana ndi atrophy kapena hypertrophy ya subcutaneous mafuta wosanjikiza pamalo a jakisoni ndikotheka. N`zothekanso kukula kwa hypersensitivity zimachitika, kuphatikizapo zokhudza zonse mwa mawonekedwe ochepa hypotension, bronchospasm, thukuta kwambiri ndi urticaria.
Ndi kukula kwa zosafunikira zotsatira, muyenera kufunsa dokotala, chifukwa ena mwa iwo angafunike kusiya mankhwala ndi chithandizo chapadera.

Contraindication

Farmasulin sinafotokozeredwe odwala omwe ali ndi hypersensitivity yodziwika bwino pazigawo zake za mankhwala.
Farmasulin ndi yoletsedwa kugwiritsidwa ntchito ndi hypoglycemia.
Odwala omwe ali ndi matenda ashuga a nthawi yayitali, odwala matenda ashuga, komanso odwala omwe amalandila beta-blockers, ayenera kugwiritsa ntchito mankhwalawa Pharmasulin mosamala, chifukwa mikhalidwe yotere ya hypoglycemia imatha kukhala yofatsa kapena yosinthika.

Muyenera kufunsa ndi dokotala za mtundu wa mankhwalawa ngati mukukula kwa vuto la adrenal, impso, chithokomiro komanso chithokomiro, komanso munjira zamatenda, monga mu nkhani iyi, insulin ingafunike.
Muzochita za ana, pazifukwa zaumoyo, amaloledwa kugwiritsa ntchito mankhwala Pharmasulin kuyambira pomwe abadwe.
Chenjezo liyenera kuchitika mukamayendetsa zinthu zomwe sizingakhale zotetezeka ndikuyendetsa galimoto munthawi ya mankhwala ndi Pharmasulin.

Mimba

Farmasulin ikhoza kugwiritsidwa ntchito mwa amayi apakati, komabe, iyenera kukumbukiridwa kuti panthawi yoyembekezera, chisamaliro chapadera chiyenera kulipidwa pakusankhidwa kwa mlingo wa insulin, chifukwa nthawi imeneyi kufunika kwa insulin kumatha kusiyanasiyana. Ndikulimbikitsidwa kuti mukafunsire dokotala wanu ngati muli ndi pakati kapena mukufuna kubereka. Madzi a m'magazi a plasma panthawi yoyembekezera ayenera kuyang'aniridwa mosamala.

Kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya mankhwalawa Farmasulin imatha kuchepetsedwa ikaphatikizidwa ndi kulera kwapakamwa, mankhwala a chithokomiro, glucocorticosteroids, beta2-adrenergic agonists, heparin, kukonzekera kwa lithiamu, diuretics, hydantoin, ndi antiepileptic mankhwala.

Pali kuchepa kwa insulini ndi kuphatikiza kwa mankhwala ophatikizira ena opatsirana pakamwa, salicylates, monoamine oxidase inhibitors, sulfonamide inhibitors, angiotensin-converting enzyme blockers, beta-adrenergic receptor blockers, ethyl mowa, octreotide, tetraflamide, tetraflamul, patrafreib, patrafrif, pulografia, patraflamide, tetraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti, patraflamiti ndi phenylbutazone.

Kuyanjana ndi mankhwala ena ndi mitundu ina yoyanjana

Mankhwala ena amakhudza kagayidwe kazakudwala. Dokotala amayenera kudziwitsidwa za chithandizo chirizonse chothandizidwa molumikizana ndi kugwiritsa ntchito insulin ya anthu.

Ngati mukufuna kugwiritsa ntchito mankhwala ena, muyenera kufunsa dokotala.

Kufunika kwa insulin kumatha kuwonjezeka ndikugwiritsa ntchito mankhwala omwe ali ndi vuto la hyperglycemic, monga njira zakulera zamkamwa, glucocorticoids, mahomoni a chithokomiro komanso mahomoni okula, danazole, β ₂ sympathomimetics (mwachitsanzo ritodrin, salbutamol, terbutaline), thiazides.

Kufunika kwa insulini kumatha kuchepa komanso kugwiritsa ntchito mankhwala omwe ali ndi vuto la hypoglycemic, monga mankhwala amkamwa a hypoglycemic, salicylates (mwachitsanzo acetylsalicylic acid), sulfaantibiotic, ma antidepressants (mao inhibitors), ena angiotensin-oletsa enzyme inhibitors (blockptenaprilpropyl, Captaprilaprilopropoprilagrilopriloprilagrilopril, osasankha β-blockers kapena mowa.

Somatostatin analogues (octreotide, lanreotide) atha kuwonjezera komanso kufooketsa kufunika kwa insulin.

Zolemba zogwiritsira ntchito

Kusintha kulikonse kwa mtundu kapena mtundu wa insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Sinthani mu ndende, mtundu (wopanga), mtundu (wofulumira, wapakatikati, wopanga-nthawi yayitali), mtundu (insulin ya nyama, insulini ya anthu, analog ya insulin ya anthu) ndi / kapena njira yokonzekera (insulin yomwe yapezeka pogwiritsa ntchito ukadaulo wa DNA wopangidwanso, mu Mosiyana ndi insulin ya nyama) pangafunike kusintha kwa mlingo.

Mlingo pochiza odwala omwe ali ndi insulin ya anthu amatha kusiyana ndi Mlingo womwe umagwiritsidwa ntchito pochiza insulin yoyambira nyama. Ngati pakufunika kusintha kwa kusintha kwa mankhwalawa, kusintha kotereku kutha kuchitika kuchokera pa mlingo woyamba kapena mkati mwa milungu ingapo kapena miyezi ingapo.

Odwala ena omwe anali ndi vuto la hypoglycemic atawasamutsa kuchokera ku regulen ya insulin yakuchokera kwa nyama kupita kumalo othandizira a insulin ya anthu, zizindikiro zoyambirira za hypoglycemia sizinatchulidwe kapena kusiyanasiyana ndi zomwe zimadziwika m'mbuyomu mwa odwalawa. Odwala omwe ali ndi kusintha kwakukulu m'magazi a glucose (mwachitsanzo, chifukwa cholimba cha mankhwala a insulin), zina mwazizindikiro zina zoyambirira za hypoglycemia mwina sizingachitike m'tsogolo, zomwe ayenera kudziwa. Zizindikiro zoyambirira za hypoglycemia zimatha kukhala zosiyana kapena zochepa kutchulidwa kwa odwala omwe ali ndi matenda a shuga komanso matenda ashuga ambiri, kapena odwala omwe akutenga mankhwala ena, monga β-blockers, motsatana ndi chithandizo chogwiritsidwa ntchito.

Hypoglycemia kapena hyperglycemic zochita zomwe sizinakonzedwenso zingapangitse kuti musakhale ndi chikumbumtima, chikomokere, kapena kufa.

Kuchepetsa dosing kapena kuyimitsidwa kwa chithandizo (makamaka kwa odwala omwe ali ndi matenda osokoneza bongo omwe amadalira insulin) kungayambitse matenda a hyperglycemia komanso omwe amapha matenda a shuga a ketoacidosis.

Ma antibodies amatha kupangidwa mu mankhwalawa a insulin ya anthu, makamaka pazotsika kuposa poyerekeza ndi insulin yanyama.

Kufunika kwa insulini kumasintha kwambiri ndi vuto la adrenal ntchito, gland ya chithokomiro, chithokomiro cha chithokomiro, matenda a impso kapena chiwindi.

Kufunika kwa insulini kungachulukenso panthawi yomwe mukudwala kapena mukulimbikitsidwa ndi nkhawa.

Kufunika kwa kusintha kwa mlingo kumatha kuchitika ngati pakuchitika masinthidwe azolimbitsa thupi kapena zakudya wamba.

Ntchito zophatikizika ndi pioglitazone

Milandu yakulephera kwa mtima yanenedwapo pamodzi ndi kugwiritsa ntchito pioglitazone ndi insulin, makamaka kwa odwala omwe ali ndi chiopsezo cha mtima Kulephera.

Gwiritsani ntchito pa nthawi yoyembekezera kapena mkaka wa m'mawere.

Kusungabe kuchuluka kwa glucose okwanira mwa amayi apakati ndikofunika kwambiri ngati amathandizidwa ndi insulin (yokhala ndi matenda a shuga). Kufunika kwa insulin nthawi zambiri kumachepetsa panthawi yoyamba kubereka, pambuyo pake kumawonjezeka panthawi yachiwiri komanso yachitatu. Amayi omwe ali ndi matenda ashuga ayenera kudziwitsa madokotala awo za mimba kapena cholinga chawo kuti akhale ndi pakati.

Kuyang'anira kwambiri shuga wamagazi ndi thanzi lathunthu ndikofunikira kwa amayi apakati omwe ali ndi matenda ashuga.

Mwa amayi omwe ali ndi matenda ashuga, nthawi yoyamwitsa, pakhoza kufunikira kuwongolera Mlingo wa insulin komanso / kapena zakudya.

Kutha kukopa momwe zinthu zikuyendera mukamayendetsa magalimoto kapena njila zina.

Hypoglycemia imatha kusokoneza chidwi cha chidwi ndi mawonekedwe a Reflex, ndiko kuti, ndizowopsa pazochitika zomwe zimafunikira makhalidwe omwe atchulidwa, mwachitsanzo, poyendetsa galimoto kapena zida zamagetsi.

Odwala adziwitsidwa za njira zomwe ayenera kuzisamala asanayendetse pofuna kupewa kukokomeza kwa hypoglycemia, makamaka ngati zizindikiro za hypoglycemia sizipezeka kapena sizikulongosola, kapena ngati kuchuluka kwa hypoglycemia kumachitika pafupipafupi. Zikatero, musayendetse.

Zotsatira zoyipa

Hypoglycemia ndi njira imodzi yodziwika yomwe imathandizira kuti odwala matenda a shuga apatsidwe matenda a shuga. Hypoglycemia yamphamvu imatha kubweretsa kukayika, nthawi zina zoopsa - mpaka kufa. Zambiri pa pafupipafupi za hypoglycemia siziperekedwa, chifukwa hypoglycemia imalumikizidwa ndi mlingo wa insulin komanso zina, monga chakudya cha wodwala komanso kuchuluka kwa zochitika zolimbitsa thupi.

Mawonetsedwe am'deralo a ziwengo amatha kuwonetsedwa ndikusintha kwa jakisoni, redness la khungu, kutupa, kuyabwa. Nthawi zambiri zimakhala masiku angapo mpaka masabata angapo. Nthawi zina, samalumikizidwa ndi insulin, koma ndi zinthu zina, mwachitsanzo, zomwe zimapangitsa kuti pakhale zotsukira khungu kapena kusadziwa bwino jakisoni.

Matenda a ziwengo ndi vuto limodzi ndipo ndi njira yofanana yolumikizira insulini, kuphatikizira kuzungulira thupi lonse, kupuma movutikira, kufinya, kuchepa kwa magazi, kuchuluka kwa mtima, komanso kuchuluka kwa thukuta. Milandu yambiri ya chifuwa chachikulu yomwe ikuluikulu imakhala pangozi. Nthawi zina zovuta zina za Farmasulin ® N NP, ziyenera kuchitidwa nthawi yomweyo. Pangakhale kofunikira kusintha m'malo mwa insulin kapena kuchiritsa odwala.

Nthawi zambiri, lipodystrophy imatha kupezeka pamalo a jakisoni.

Milandu ya edema idanenedwa ndikugwiritsa ntchito mankhwala a insulin, makamaka pazochitika zomwe zimachepetsedwa kagayidwe kake, adasinthika chifukwa cha insulin Therapy.

Kupanga ndi mawonekedwe a kumasulidwa

FARMASULIN® H NP

kukayikira d / mkati. 100 IU / ml fl. 10 ml, Na. 1
kukayikira d / mkati. 100 IU / ml cartridge 3 ml, No. 5

Human Insulin 100 IU / ml
Zosakaniza zina: m-cresol, glycerol, phenol, protamine sulfate, zinc oxide, sodium phosphate dibasic, hydrochloric acid 10% yankho kapena sodium hydroxide 10% yankho (mpaka pH 6.9-7.5), madzi wa jakisoni.
1 ml ya Farmasulin N NP ili ndi 100 IU ya insulin yaumunthu yopangidwa pogwiritsa ntchito ukadaulo wa DNA.

FARMASULIN ® H 30/70

kukayikira d / mkati. 100 IU / ml fl. 10 ml, Na. 1
kukayikira d / mkati. 100 IU / ml cartridge 3 ml, No. 5

Human Insulin 100 IU / ml
Zosakaniza zina: m-cresol, glycerol, phenol, protamine sulfate, zinc oxide, sodium phosphate dibasic, hydrochloric acid 10% yankho kapena sodium hydroxide 10% yankho (mpaka pH 6.9-7.5), madzi wa jakisoni.
1 ml ya Farmasulin H 30/70 ili ndi 100 IU ya insulin yaumunthu yopangidwa pogwiritsa ntchito ukadaulo wa DNA.

Pharmacokinetics

Farmasulin N - insulin yogwira ntchito mwachangu, ndikukonzekera kwa insulin yaumunthu yomwe imapezedwa ndi tekinoloje ya DNA.
Ma pharmacokinetics a insulin samawonetsa zochita za mahomoni.
Kukhazikika kwa mavutowa ndi mphindi 30 pambuyo pothandizidwa ndi subcutaneous. Chiwonetsero chachikulu kwambiri chimawonedwa pakati pa 1 ndi 3 mawola jakisoni. Kutalika kwakanthawi kovomerezeka ndikuchokera kwa maola 5 mpaka 7. Zochita za insulin zimasiyana malinga ndi kukula kwa mlingo wake, malo opaka jakisoni, kutentha kozungulira ndi zochitika zolimbitsa thupi za wodwalayo.
Pa maphunziro a poizoni, palibe zoyipa zomwe zimakhudzana ndi kugwiritsa ntchito mankhwalawa.