AKTRAPID NM PENFill (ACTRAPID HM PENFill) malangizo ogwiritsira ntchito
Mtundu woyamba wa matenda a shuga 1, mellitus wa mtundu 2 shuga: gawo la kukana mankhwala osokoneza bongo a hypoglycemic, kukana pang'ono kwa mankhwala amkamwa a hypoglycemic (mankhwala osakanikirana),
matenda ashuga ketoacidosis, ketoacidotic ndi hyperosmolar coma, matenda osokoneza bongo omwe adachitika panthawi yoyembekezera (ngati chithandizo cha zakudya sichitha),
ntchito kwakanthawi odwala omwe ali ndi matenda osokoneza bongo othana ndi matenda opatsirana chifukwa cha kutentha thupi, kugwiritsa ntchito maopaleshoni, kuvulala, kubala, kusokonezeka kwa metabolic, musanafike pokonzekera chithandizo cha insulin.
Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD
Njira yothetsera jakisoni ndi yowonekera, yopanda utoto.
| 1 ml | |
| sungunuka wa insulin (maumboni amtundu wa anthu) | 100 IU * |
Othandizira: zinc chloride, glycerol, metacresol, hydrochloric acid ndi / kapena sodium hydroxide solution (kukhalabe ndi pH), madzi d / i.
* 1 IU imafanana ndi 35 μg ya insulin ya munthu wosafunikira.
3 ml - makatoni agalasi (5) - mapaketi a makatoni.
Zotsatira za pharmacological
Actrapid ® NM ndikapangidwe ka insulin kofupikitsa kamene kamapangidwanso ndi DNA yaumboni wamatsenga pogwiritsa ntchito Saccharomyces cerevisiae strain. Kutsika kwa glucose m'magazi kumachitika chifukwa cha kuwonjezereka kwa mayendedwe ake amkati atatha kumangiriza insulini kupita ku insulin zolandila minofu ndi adipose minofu ndikuchepa kwamtundu womwewo kwa shuga. Matenda a plasma glucose (mpaka 4,4-6.1 mmol / l) mwa iv. A Actrapid ® NM ali m'manja mwa odwala omwe amachitidwa opaleshoni yayikulu (odwala 204 omwe ali ndi matenda a shuga komanso 1344 odwala popanda matenda a shuga) (plasma glucose concentration> 10 mmol / L), yachepetsa kufa kwa 42% (4.6% m'malo mwa 8%).
Machitidwe a Actrapid ® NM a mankhwalawa amayamba pakati pa theka la ola pambuyo pa kukhazikitsidwa, ndipo mphamvu yayikulu ikuwonekera mkati mwa maola 1.5-3,5, pomwe nthawi yonseyi ikuchitika pafupifupi maola 7-8.
Deta Yotetezera
M'maphunziro a preclinical, kuphatikizapo maphunziro a chitetezo cha pharmacological, maphunziro a kawopsedwe omwe ali ndi Mlingo wambiri, maphunziro a genotoxicity, chiwopsezo cha carcinogenic komanso zotsatira zoyipa pamagawo obala, palibe vuto lililonse kwa anthu lomwe linadziwika.
Pharmacokinetics
T 1/2 ya insulin kuchokera m'magazi ndi mphindi zochepa chabe.
Kutalika kwa nthawi ya kukonzekera kwa insulin kumachitika makamaka chifukwa cha kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, pa mlingo wa insulin, njira ndi malo oyendetsera, makulidwe a subcutaneous mafuta wosanjikiza ndi mtundu wa matenda osokoneza bongo). Chifukwa chake, magawo a pharmacokinetic a insulin ali ndi kusinthasintha kwakukulu kwakukulu ndi kwina kwamunthu payekha.
C max wa insulin m'madzi a m'magazi amatheka mkati mwa maola 1.5-2,5 pambuyo pa sc.
Palibe zomangamanga zomanga mapuloteni a plasma zimadziwika, kupatulapo ma antibodies a insulin (ngati alipo).
Insulin yaumunthu imapangidwa ndi ma insulinase kapena ma enzyme osokoneza bongo a insulin, komanso mwina ndi protein disulfide isomerase.
Amaganiziridwa kuti mu molekyulu ya insulin ya anthu pali malo angapo a cleavage (hydrolysis), komabe, palibe amodzi a metabolites omwe amapangidwa chifukwa cha cleavage akugwira ntchito.
T 1/2 imatsimikiziridwa ndi kuchuluka kwa mayamwidwe kuchokera ku minofu yaying'ono. Chifukwa chake, T 1/2 ikhoza kukhala kuyamwa, m'malo mochotsa insulini kuchokera ku plasma (T 1/2 ya insulin m'magazi ndi mphindi zochepa chabe). Kafukufuku awonetsa kuti T 1/2 ili pafupi maola 2-5.
Ana ndi achinyamata
Mbiri ya pharmacokinetic ya mankhwala a Actrapid ® NM adaphunziridwa mgulu la ana omwe ali ndi matenda ashuga (anthu 18) azaka 6 - 6, komanso achinyamata (azaka 13 mpaka 17). Ngakhale zambiri zomwe zimawerengedwa zimawonedwa ngati zochepa, komabe amawonetsa kuti mbiri ya pharmacokinetic ya Actrapid ® NM mwa ana ndi achinyamata ndiofanana ndi zomwe zimachitika mwa akulu. Nthawi yomweyo, kusiyana kunawululidwa pakati pa mibadwo yosiyanasiyana ndi chisonyezo monga C max, chomwe chikugogomezeranso kufunika kwa kusankha kwa munthu payekha.
Mlingo
Mankhwalawa adapangira SC ndi / pakukhazikitsa.
Mlingo wa mankhwalawa amasankhidwa payekha, poganizira zosowa za wodwala.
Nthawi zambiri, zofunika za insulini zimachokera pa 0,3 mpaka 1 IU / kg / tsiku. Kufunika kwa insulin tsiku lililonse kumatha kukhala kwabwino kwambiri kwa odwala omwe ali ndi insulin (mwachitsanzo, nthawi yakutha msinkhu, komanso odwala omwe ali ndi kunenepa kwambiri), komanso otsika mwa odwala omwe ali ndi zotsalira za insulin.
Mankhwalawa umaperekedwa kwa mphindi 30 asanadye kapena chakudya. Actrapid ® NM ndi insulin yochepa ndipo imatha kugwiritsidwa ntchito limodzi ndi ma insulin.
Actrapid ® NM nthawi zambiri imayendetsedwa mwachisawawa mdera lakhoma lamkati lakumbuyo. Ngati izi ndizotheka, ndiye kuti jakisoni amathanso kuchitika m'tchafu, m'chigawo cha gluteal kapena m'dera la minofu ya m'mapazi. Ndi kuyambitsa kwa mankhwala m'dera lakhomopo lakhomopo, mayamwidwe mwachangu amatheka kuposa momwe angayambitsire madera ena. Ngati jakisoniyo wapangidwira pakhungu lalitali, ngozi ya mankhwalawo mwangozi imachepetsedwa. Singano imayenera kukhalabe pansi pakhungu kwa masekondi 6 osachepera, omwe amatsimikizira mlingo wokwanira. Ndikofunikira nthawi zonse kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse chiopsezo cha lipodystrophy. Actrapid ® NM ndiyothekanso kulowa mkati / momwemo njirazi zitha kuchitidwa ndi katswiri wazachipatala.
Mu / pakukhazikitsa kwa mankhwala a Actrapid ® NM Penfill ® kuchokera ku cartridge ndikololedwa kokha kupatula mabotolo. Pankhaniyi, muyenera kumwa mankhwala osokoneza bongo a insulini popanda kudya mpweya kapena kulowerera pogwiritsa ntchito kulowetsedwa. Njirayi iyenera kuchitidwa kokha ndi dokotala.
Actrapid ® NM Penfill ® idapangidwa kuti izigwiritsidwa ntchito ndi mabungwe a Novo Nordisk insulin jakisoni ndi singano za NovoFine ® kapena NovoTvist ®. Malangizo atsatanetsatane ogwiritsira ntchito ndi kuyang'anira mankhwalawa amayenera kuonedwa.
Matenda okhala ndi vuto limodzi, makamaka opatsirana komanso kutentha thupi, nthawi zambiri amalimbikitsa kufunika kwa insulin. Kusintha kwa magazi kungafunikenso ngati wodwala ali ndi matenda a impso, chiwindi, mkhutu wa adrenal ntchito, pituitary kapena chithokomiro cha chithokomiro.
Kufunika kosinthidwa kwa mlingo kumatha kuonekanso posintha zolimbitsa thupi kapena zakudya zomwe wodwala amadya. Kusintha kwa Mlingo kungafunike posamutsa wodwala kuchokera ku mtundu wina wa insulin kupita ku ina.
Zotsatira zoyipa
Chochitika chovuta kwambiri chambiri ndi insulin ndi hypoglycemia. Panthawi ya mayeso azachipatala, komanso munthawi yogwiritsa ntchito mankhwalawa atamasulidwa pamsika wa ogula, zidapezeka kuti zochitika za hypoglycemia zimasiyanasiyana malinga ndi kuchuluka kwa odwala, kuchuluka kwa mankhwalawa, komanso kuchuluka kwa kayendedwe ka glycemic.
Pa gawo loyambirira la insulin, zolakwika zotupa, edema ndi zimachitika zimapezeka pamalo a jakisoni (kuphatikiza ululu, kufiyira, ming'oma, kutupa, kuphwanya, kutupa ndi kuyunkhira pamalo a jekeseni. Zizindikirozi nthawi zambiri zimakhala zakanthawi. Kusintha kwapang'onopang'ono pakuwongolera glycemic kumatha kubweretsa mkhalidwe wa "ululu wammbuyo wamitsempha," womwe umatha kusintha. Kulimbitsa insulin mankhwala ndikusintha kolimba kwa mphamvu ya kagayidwe kazakudya kungayambitse kuwonongeka kwakanthawi pamikhalidwe ya matenda ashuga, pamene kusintha kwakanthawi kwakanthawi ka glycemic kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy.
Zotsatira zonse zoyipa zomwe zaperekedwa pansipa, kutengera data kuchokera ku mayeso azachipatala, zimayikidwa m'magulu molingana ndi kukula kwa chitukuko malinga ndi MedDRA ndi kachitidwe ka ziwalo. Zotsatira zoyipa zimatchulidwa kuti:
- nthawi zambiri (≥ 1/10),
- Nthawi zambiri (Kamutu: 1/100 kupita ku Matenda a Matenda a Katemera):
- pafupipafupi - urticaria, zotupa pakhungu,
- kawirikawiri - anaphylactic zimachitika.
Matenda a Metabolic ndi zakudya:
- nthawi zambiri - hypoglycemia.
Kuphwanya kwamanjenje:
- pafupipafupi - zotumphukira neuropathy ("pachimake ululu neuropathy").
Kuphwanya gawo la masomphenyawo:
- pafupipafupi - zolakwika zokonzanso,
- kawirikawiri - matenda ashuga retinopathy.
Zovuta za pakhungu ndi minofu yolowera:
- pafupipafupi - lipodystrophy.
Zovuta ndi zovuta zina pamalo opangira jakisoni:
- pafupipafupi - zimachitika pamalo jakisoni,
- pafupipafupi - edema.
Kufotokozera kwamomwe munthu amachitikira:
Zosowa kwambiri zamatenda ophatikizidwa ndi khungu zimakhudzidwa (kuphatikiza zotupa zapakhungu, kuyabwa, thukuta, kusokonezeka kwa m'mimba, angioedema, kupuma movutikira, kutsitsa kwa mtima, kuchepa kwa magazi, komanso kukomoka / kusazindikira, komwe kungakhale pachiwopsezo cha moyo).
Hypoglycemia ndi njira yodziwika kwambiri yotsatirira. Zimatha kukhala ngati mlingo wa insulini ndiwokwera kwambiri poyerekeza ndi kufunika kwa insulin. Hypoglycemia kwambiri imatha kutha kwamitsempha ndikukayika, kukhumudwa kwakanthawi kapena kosasinthika kwa ubongo, kapena ngakhale kufa. Zizindikiro za hypoglycemia, monga lamulo, zimayamba mwadzidzidzi. Izi zitha kuphatikizira "thukuta lozizira", khungu la thupi, kutopa kwambiri, manjenje kapena kunjenjemera, nkhawa, kutopa kosazolowereka, kapena kufooka, kukhumudwa, kuchepa kwa chidwi, kugona, kugona kwambiri, kuona msanga, mutu, nseru, komanso kuthamanga kugunda kwa mtima.
Nthawi zambiri za lipodystrophy zalembedwa. Lipodystrophy imatha kupezeka pamalo a jakisoni.
Mimba komanso kuyamwa
Palibe choletsa kugwiritsa ntchito insulin panthawi yapakati, popeza insulin siyidutsa chotchinga.
Onsewa a hypoglycemia ndi hyperglycemia, omwe amatha kukhala ndi vuto losankha bwino, amalimbikitsa chiopsezo cha kusokonezeka kwa fetal ndi kufa kwa fetal. Amayi oyembekezera omwe ali ndi matenda ashuga amayenera kuyang'aniridwa panthawi yonse yomwe ali ndi pakati, ayenera kuti amawongolera kuchuluka kwa shuga wamagazi, malingaliro omwewo amagwiranso ntchito kwa amayi omwe akukonzekera kutenga pakati.
Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndipo kumawonjezeka pang'onopang'ono kwachiwiri komanso kachitatu.
Pambuyo pobadwa mwana, kufunika kwa insulin, monga lamulo, kumabwereranso msanga pazomwe zimawonedwa musanakhale ndi pakati.
Palibenso zoletsa kugwiritsa ntchito mankhwalawa Actrapid ® NM panthawi yoyamwitsa. Kuchita insulin kwa amayi oyamwitsa sikowopsa kwa mwana. Komabe, mayi angafunike kusintha njira ya Actrapid ® NM ndi / kapena zakudya.
Mankhwala
Yogwira pophika mankhwala Actrapid Hm Penfill sungunuka wa anthu. Vutoli limapezeka kudzera mwa njira zofananira za deoxyribonucleic acid. Ntchito yayikulu ya mankhwalawa, monga mankhwala ena aliwonse a insulin, ndikuyang'anira. Kudzera mu izi, kuchepa kwa shuga m'magazi kumachitika, komanso kutseguka kwa shuga m'magazi a minofu ya thupi ndi kukakamiza kwa kupanga kwa shuga ndi chiwindi. Kuphatikiza apo, pali kutsika kwapang'onopang'ono pamagulu akusowa kwamafuta m'maselo am'mafuta ndikuyambitsa kuphatikiza mapuloteni. Zakhazikitsidwa mwachipatala kuti kutsitsa kuchuluka kwa shuga m'magazi pambuyo poti wodwala wagwiritsa ntchito Actrapid kumayamba pakadutsa mphindi makumi atatu. Mankhwalawa amafikira pakukwanira kwake kwakanthawi kwakanthawi kokwanira ola limodzi mpaka maola atatu. Kutalika kwa kuchitapo kanthu, monga lamulo, sikupitirira maola asanu ndi atatu. Dziwani kuti mawonekedwe apakanthawi angayerekeze kutengera kutengera kwa wodwala.
Kupanga ndi mawonekedwe a kumasulidwa
Zotsatira zotsatirazi zimagwiritsidwa ntchito popanga mankhwalawa: • zinthu zogwiritsidwa ntchito mwanjira ya insulin yamankhwala aumunthu, • zina zowonjezera, kuphatikizapo zinc chloride, grencerin mowa, metacresol, hydrochloric acid, sodium oxidanide, madzi oyeretsedwa. Kutulutsidwa kwa mankhwalawa kuli ngati njira yankho la subcutaneous ndi mtsempha wama mtsempha. Njira yothetsera vutoli ndi chinthu chimodzi, chomwe nthawi zambiri chimakhala chopanda utoto. Njira yayikulu yololera ndi mabotolo agalasi. Mbale zimayikidwa mu zotumphukira zotulutsa mu kuchuluka kwa zidutswa zitatu. Matumba asanu a matuza, limodzi ndi malangizo ogwiritsira ntchito, amaikidwa m'makatoni amitundu yoyera yoyera.
Zotsatira zoyipa
Zotsatira zotsatirazi zimatha kugwiritsa ntchito mankhwalawa: • Kutuluka thukuta, • mantha, • kunjenjemera zala, kumvekera mseru, • kuphwanya kwamiyendo ya minofu ya mtima, • kukokana kwa miyendo, • kutupa kwa nkhope, • kutsitsa magazi, • kupuma movutikira, • kupindika, kuyabwa.
Contraindication
Mankhwala Aktrapid Hm sayenera kugwiritsidwa ntchito ngati m'modzi mwa zotsatirazi akupezeka: kutsitsa magazi.
Mimba komanso kuyamwa
Zomwe zilipo pakadali pano zikuwonetsa kuti pathological kapena vuto lina losakhudzidwa kwa mwana wosabadwayo silinapezeke pakugwiritsa ntchito Actrapid. Nthawi yomweyo, kuyang'anira okhazikika omwe ali ndi pakati omwe ali ndi matenda osokoneza bongo komanso kugwiritsa ntchito mankhwalawa akulimbikitsidwa. Zimatsimikiziridwa kuti kufunikira kwa mankhwala othandizira kumachitika kuyambira sabata la khumi ndi chinayi la mimba ndipo pang'onopang'ono limakula. Pambuyo pobereka, kufunikira kwa insulin kumachepa, koma pakapita nthawi yochepa kumabweranso pamlingo wake wam'mbuyo. Mukamayamwitsa, kugwiritsa ntchito mankhwalawa kumaloledwa. Nthawi zina kusintha kwa mlingo kumafunika malinga ndi momwe wodwalayo akumvera.
Kugwiritsa: njira ndi mawonekedwe
Mankhwala a Actrapid Hm Penfill amagwiritsidwa ntchito mobisa komanso m'mitsempha. Mlingo woyenera umaperekedwa ndi adokotala poyerekeza ndi mayeso omwe anachitika. Chifukwa chakuti zochita za insulin yosungunuka ndi yayifupi, chimodzi mwazomwe tikuyigwiritsa ntchito ndikofunikira kuphatikiza mankhwalawa ndi ma insulin a nthawi yayitali kapena ma insulin apakati.Kufunika kwa tsiku ndi tsiku kwa insulin yosungunuka, monga lamulo, kumasiyana kuchokera pazigawo zitatu mpaka magawo onse pa kilogalamu imodzi yolemera. Nthawi zina kufunika kwa insulini kumaposa kuchuluka kwa digito kwa odwala onenepa kwambiri kapena muunyamata. Kukhazikitsidwa kwa mankhwalawa kuyenera kuchitika kwa theka la ola musanadye. Kubaya jekeseni wa m'mimba kuyenera kuchitidwa mbali zina za thupi m'njira yothandizira kuti pokhapokha pokhapokha paliponse pakumenyedwa singano pamalo omwewo. Tikulimbikitsidwanso kusamala ndi kasamalidwe koyambira kuti tisatengere mwangozi yankho mu mtsempha wamagazi. Kuyamwa mwachangu kwambiri kumachitika mukamayambitsa zigawo zam'mimba. Kuti adziyese wokha, wodwala ayenera kutsatira malamulo angapo osavuta. Izi ndi monga: 1. Musanagwiritse ntchito Actrapid, yankho liyenera kuyang'aniridwa mosamala. Iyenera kukhala yunifolomu, yopanda utoto. Ngati kusefukira, kukhuthala kapena vuto lililonse likapezeka, kugwiritsa ntchito mankhwalawa ndizoletsedwa. 2. Asanayambe makonzedwe, tikulimbikitsidwa kuti muzisamba m'manja mokwanira, komanso malo oyikirako. 3. Tsegulani kapu ya cholembera ndikuyika singano yatsopano, ndikusunthira mpaka malire. Kubayira kwina kulikonse kwamunthu insulin kuyenera kuchitidwa ndi singano yatsopano. 4. Tatulutsa singano mu nkhata, ndi dzanja limodzi konzani malo operekera jekeseni posonkhanitsa khungu mu khola laling'ono, ndi linalo, fufuzani syringe kuti zomwe zili mkati zituluke. Onetsetsani kuti palibe Mbale yemwe akukhaliratu. 5. Ikani singano mu crease ndikuyika zomwe zili mu vial pansi pa khungu. 6. Pambuyo pakuyika, tulutsani singano, ndikuyika malo a jakisoni kwakanthawi kochepa. 7. Vula singano m'manja ndikuyitaya. Intravenous makonzedwe angathe kuchitika kokha ndi katswiri waluso.
Kuchita ndi mankhwala ena
Pali mitundu ingapo ya mankhwala omwe amakhudza kuchuluka kwa glucose m'thupi nthawi yomwe amagwiritsidwa ntchito molumikizana ndi Actrapid Hm. Chifukwa chake, mankhwalawa omwe ali ndi mphamvu yochulukirapo ya monoamine oxidase ndi angiotensin potembenuza enzyme, komanso mankhwala monga tetracycline, ethyl- (para-chlorophenoxy) -isobutyrate, dexfenfluramine, cyclophosphamidum, othandizira njira za anabolic mthupi, amatha kupititsa patsogolo mphamvu ya insulin ya anthu. Ma diuretics, androgenrogen opanga, heparin, tridclic antidepressants, glucocorticosteroids, psychotropic mankhwala, zotumphukira za tyrosine amino acid zimatha kukhala zotsutsana ndi insulin. Mothandizidwa ndi 3,4,5-trimethoxybenzoate methylreserpate ndi salicylic acid analgesics, kusintha kwa glucose m'magazi ndikotheka, zonse ziwiri pakuchepa ndikukula.
Bongo
Pakadali pano, mlingo wa mankhwala a Actrapid, omwe ungayambitse mankhwala osokoneza bongo, sunadziwika. Nthawi yomweyo, zikachitika, kuchepa kwa shuga m'magazi pansi pazomwe zimakhazikitsidwa ndizotheka. Pazinthu izi, zizindikiro zotsatirazi zikuwoneka: • kupweteka mutu, • kusokoneza malo, • kuchepa mphamvu, kusowa mphamvu, • kutulutsa thukuta, kusintha masinthidwe amtima, • kunjenjemera kwa zala, , • kusokonekera kwa psychoemotional. Ngati kuchepa kwa shuga sikumadzetsa zovuta zochulukirapo, ndiye kuti wodwalayo amatha kuchotsa payekha mwa kumwa glucose pakamwa. Pazifukwa izi, tikulimbikitsidwa kuti anthu omwe ali ndi matenda ashuga nthawi zonse azikhala ndi chakudya chokoma kapena zakumwa. Zikatero, chifukwa chochepetsa shuga m'magazi, wodwalayo amasiya kuzindikira, makonzedwe apakhungu a dextrose ofunikira amafunikira, omwe angachitike ndi katswiri waluso.
Malangizo apadera
Kusinthana ndi mankhwala ena a insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Pakuphwanya zakudya zomwe zidakhazikitsidwa pakudya, komanso kuwonjezeka kwa zochitika za tsiku ndi tsiku, kusintha kwakofunikira kumafunika. Kukula kwa matenda a impso ndi chiwindi kungachepetse kufunika kwa insulini chifukwa cha kuchepa kwa machitidwe ake a cleavage. Nthawi yomweyo, kupezeka kwa matenda obwera chifukwa chodwala mwina kungakhale maziko owonjezereka a mankhwalawa. Mlingo wa insulin umatha kusinthanso matenda amisala. Kugwiritsa ntchito mankhwala ena kuyenera kuchitidwa ndi malingaliro oyenerera a akatswiri odziwa bwino ntchito yawo. Popeza kutsika komanso kuchuluka kwa shuga m'magazi kumatha panthawi yomwe mukumwa mankhwalawa, izi zimatha kusokoneza ndende. Nthawi ngati izi, muyenera kusiya kuyendetsa galimoto ndi zochitika zina zomwe zimafuna chisamaliro chochuluka.
Mankhwala Aktrapid Hm Penfill ali ndi zinthu zotsatirazi zomwe zili ndi mawonekedwe ofanana: Apidra Solostar, Gensulin R, Biosulin R, Gansulin R, Insulin R bio R, Insuran R, Rosinsulin R, Insuman Rapid GT, Rinsulin R, Vosulin-Rsp, Novorap , Insuvit N, Insugen-R, Insular Asset, Farmasulin N, Humodar R, Himulin Regular.
Ndemanga za Mankhwala
Odwala omwe amagwiritsa ntchito mankhwala a Actrapid Hm, mokulira, amazindikiritsa mbali yake moyenera komanso mwachangu. Odwala ena amakumana ndi zovuta pakumwa mankhwalawo, koma nthawi zambiri izi zimachitika chifukwa cha mlingo wosankhidwa bwino.
Chilolezo cha Pharmacy LO-77-02-010329 cha pa June 18, 2019
Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo
Mlingo ndi njira yoyendetsera mankhwalawa imatsimikiziridwa payekhapayekha malinga ndi kuchuluka kwa glucose m'magazi musanadye ndi maola 1-2 mukatha kudya, komanso kutengera ndi kuchuluka kwa glucosuria ndi machitidwe a matendawa.
Mankhwala amatumizidwa s / c, mu / m, mu / mkati, mphindi 15-30 musanadye. Njira yodziwika kwambiri yoyendetsera ntchito ndi sc. Ndi matenda ashuga a ketoacidosis, chikomokere cha matenda a shuga, pakachitika opaleshoni - mu / mu ndi / m.
Ndi monotherapy, pafupipafupi makonzedwe nthawi zambiri amakhala 3 katatu patsiku (ngati kuli kotheka, mpaka nthawi 5-6 patsiku), tsamba la jakisoni limasinthidwa nthawi iliyonse kupewa chitukuko cha lipodystrophy (atrophy kapena hypertrophy ya subcutaneous mafuta).
Pulogalamu ya tsiku ndi tsiku imakhala ya 30 kapI PESCES, mwa ana - 8 PIERES, ndiye kuti muyezo wa tsiku ndi tsiku - 0,5-1 PIECES / kg kapena 30 mpaka 40 PIECES katatu pa tsiku, ngati kuli kotheka - 5-6 pa tsiku. Pa mlingo wa tsiku ndi tsiku wopitilira 0,6 U / kg, insulin iyenera kuperekedwa ngati ma jakisoni a 2 kapena kuposa m'malo osiyanasiyana a thupi.
Ndikotheka kuphatikiza ndi ma insulin omwe amakhala nthawi yayitali.
Njira yothetsera insulini imatengedwa kuchokera ku vial ndi kuboola ndi singano yosalala ya singano yoyimitsira ndi waya yopukutira mutachotsa kapu ya aluminium ndi ethanol.
Mafunso, mayankho, ndemanga pa mankhwala a Actrapid NM Penfill
Zomwe zimaperekedwa zimakonzekera akatswiri azamankhwala komanso zamankhwala. Chidziwitso chokwanira chokhudza mankhwalawa chili m'malangizo omwe amaphatikizidwa ndi zomwe amapanga ndi wopanga. Palibe chidziwitso chomwe chatumizidwa patsamba lino kapena tsamba lililonse la tsamba lathu chomwe chingagwire ntchito ngati cholowa m'malo mwapadera kwa katswiri.Kuyanjana kwa mankhwala osokoneza bongo
Pali mankhwala angapo omwe amakhudza kufunika kwa insulin. Hypoglycemic zotsatira za insulin patsogolo m'kamwa wothandizila hypoglycemic, monoamine oxidase zoletsa, angiotensin akatembenuka zoletsa enzyme, carbonic zoletsa anhydrase, kusankha beta-blockers, bromocriptine, sulfonamides, anabolic mankhwala, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, mankhwala lifiyamu salicylates .
Mphamvu ya hypoglycemic ya insulin imafooketsedwa ndi kulera kwapakamwa, glucocorticosteroids, mahomoni a chithokomiro, thiazide diuretics, heparin, tridclic antidepressants, sympathomimetics, kukula kwa mahomoni (somatropin), danazol, clonidine, liwiro la calcium calcium blockers, difenin, diazoxide.
Beta-blockers amatha kufinya zizindikiro za hypoglycemia ndikupangitsa kuti zikhale zovuta kuchira ku hypoglycemia.
Octreotide / lanreotide imatha kuwonjezeka ndikuchepetsa kufunikira kwa insulin.
Mowa ungapangitse kapena kuchepetsa mphamvu ya insogulin.
Actrapid ® NM imangowonjezedwa pazowonjezera zomwe zimadziwika kuti ndizogwirizana. Mankhwala ena (mwachitsanzo, mankhwala okhala ndi ma thiols kapena sulfite) akawonjezeredwa ndi yankho la insulin angayambitse kuchepa.
Zosungidwa zamankhwala
Sungani mankhwalawo pa kutentha 2 2 C mpaka 8 ° C (mufiriji), koma osati pafupi ndi mufiriji. Osamawuma. Sungani makatoni makatoni kuti muteteze.
Pa makatiriji otseguka:
- Osasunga mufiriji. Sungani kutentha osapitirira 30 ° C milungu isanu ndi umodzi.
Actrapid ® NM Penfill ® iyenera kutetezedwa kuti isayerekezedwe ndi kutentha kwambiri ndi kuwala. Pewani kufikira ana.
Malangizo ogwiritsira ntchito
Malinga ndi malangizo ogwiritsira ntchito, mlingo wa Actrapid NM umatsimikiziridwa ndi dokotala aliyense payekha malinga ndi momwe wodwalayo alili. Mukamagwiritsa ntchito Actrapid NM mu mawonekedwe ake oyera, nthawi zambiri imakhazikitsidwa katatu patsiku (mwina mpaka nthawi 5-6). Mankhwalawa amatha kuperekedwa mosavuta, kudzera m'mitsempha kapena m'mitsempha.
Pakatha mphindi 30 mutatha kugwiritsa ntchito mankhwalawa, muyenera kudya chakudya. Ndi kusankha kwa insulin mankhwala, ndizotheka kugwiritsa ntchito Actrapid NM kuphatikiza omwe akhala akuchita insulin. Actrapid NM ikhoza kusakanizidwa mu syringe yomweyo ndi ma insulin ena oyeretsedwa kwambiri. Akaphatikizidwa ndi insulin, inshuwaransi iyenera kuchitidwa mwachangu. Akasakanizidwa ndi ma insulin omwe amakhala ndi nthawi yayitali, a HMrrid ayenera kuyambitsidwa mu syringe yoyamba.
Kugwiritsira ntchito kwofananira kwa corticosteroids, zoletsa za MAO, kulera kwa mahomoni, mowa, chithandizo chokhala ndi mahomoni a chithokomiro kungapangitse kuti pakufunika insulin.
Pezani mdani wolumbirira MUSHROOM wa misomali! Misomali yanu idzatsukidwa m'masiku atatu! Tengani.
Momwe mungasinthiretu kusintha kwakanthawi kwa zaka 40? Chinsinsi ndi chosavuta, lembani.
Kutopa ndi zotupa? Pali njira yotulukirapo! Itha kuchiritsidwa kunyumba masiku ochepa, muyenera kutero.
Pafupifupi kupezeka kwa mphutsi akuti KUDULA mkamwa! Kamodzi patsiku, kumwa madzi ndi dontho ..
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Matenda a shuga kapena mapiritsi
Njira yochizira matenda ashuga. Zonse Zokhudza Mankhwala A Shuga Mukapenda nkhaniyi, muphunzira momwe mungachiritsire matenda ashuga amtundu wa 2 ndipo, nthawi zina, lembani matenda ashuga 1 ndi mapiritsi. ... -
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