Diabeteson MV

Diabeteson MV (Diabeteson MR): 2 ndemanga za madotolo, ndemanga zitatu za odwala, malangizo ogwiritsira ntchito, ma analogu, infographics, mawonekedwe amodzi a 1 amasulidwe.

Madotolo amakambirana za matenda a shuga a mellitus MV

Ndi kuwonongeka kwa matenda ashuga, mankhwalawa amakwaniritsa glycemia mwangwiro. Kutulutsidwa kosinthidwa kumathandiza kupewa hypoglycemia, chifukwa chake mankhwalawa ndi oyenera kwa okalamba, komanso odwala omwe ali ndi matenda amtima.

Nthawi zambiri, koma zimayambitsa hypoglycemia.

Ndimagwiritsa ntchito mankhwalawa kwambiri machitidwe anga. Mtengo wake ndi wololera, ntchito yake ndi yabwino.

Mankhwala "Diabeteson MV" amagwiritsidwa ntchito mosiyanasiyana Mlingo wa 30 kapena 60 mg. Awa ndi mapiritsi osinthidwa osinthika. Mankhwala ali ndi othandiza kwambiri komanso amawonekera pazochita. Palibe mavuto, zotsatira za mankhwalawa zimayamba pambuyo pake mwachangu. Kukhazikitsidwa bwino mankhwalawa matenda a shuga.

Makonda Odwala a Diabeteson MV

Mwamuna wanga ali ndi shuga wambiri. Kwa zaka zingapo, amafunafuna mankhwala omwe amachepetsa shuga ndipo, koposa zonse, azikhala wathanzi. Nthawi yotsatira yomwe timakambirana ndi adotolo, tidalangizidwa za "Diabeteson MV". Patatha mwezi umodzi atamwa mankhwalawo, shuga adayamba kuchita bwino. Tsopano mwamuna wanga ali ndi 8.2 mm. Izi, zachidziwikire, ndizokwera pang'ono. Koma ndi bwinoko kuposa mmilimita khumi ndi zinai m'mbuyomu.

Mlingo wa "Diabeteson" wa 60 mg patsiku, osachepetsedwa kwambiri. M'mawa panali shuga 10-13. Kenako adotolo adakulitsa mlingo mpaka 90 mg (1.5 tabu). Tsopano m'mawa, ndikamayesa shuga, zinali ngakhale 6. Ndikuyenera kunena kuti zambiri zimatengera ngati ndimatsatira zakudya. Zomwezo 6 zokha ndi pomwe padalibe zovuta za kudya. Inde, kuphatikiza kuchita masewera olimbitsa thupi pang'ono.

Ndakhala ndikutenga kwa chaka, zotsatira zabwino, zotsatira zake zikuwonekera komanso mwachangu. Zotsatira zoyipa sizimachitika. Chithandizo chachikulu.

Pharmacology

Oral hypoglycemic wothandizira, yemwe amapezeka m'badwo wachiwiri. Imayendetsa katulutsidwe ka insulin ndi β-cell ya kapamba. Kuchulukitsa chidwi cha zotumphukira zimakhala kuti insulin. Zikuwoneka, zimapangitsa ntchito ya ma intracellular enzymes (makamaka, minofu glycogen synthetase). Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Kubwezeretsanso pachimake cha insulin katulutsidwe, kumachepetsa chiwerengero cha hyperglycemia pambuyo pake.

Glyclazide imachepetsa kuphatikiza kwa maselo ndi kuphatikiza, imachepetsa kukula kwa parietal thrombus, ndikuwonjezera ntchito ya mtima. Matendawa mtima kukhathamira. Ili ndi anti-atherogenic katundu: imatsitsa kuchuluka kwa cholesterol yathunthu (Ch) ndi LDL-C m'magazi, imachulukitsa ndende ya HDL-C komanso imachepetsa kuchuluka kwa zopitilira muyeso. Zimalepheretsa kukula kwa microthrombosis ndi atherosulinosis. Amasintha kusintha kwakachulukidwe. Imachepetsa mphamvu ya mtima ku adrenaline.

Ndi diabetesic nephropathy yogwiritsa ntchito gliclazide nthawi yayitali, kuchepa kwakukulu kwa proteinuria kumadziwika.

Pharmacokinetics

Pambuyo pakumwa pakamwa, imatengedwa mwachangu kuchokera mumimba. C_max m'magazi amafikira pafupifupi maola 4 atatha kumwa kamodzi kwa 80 mg.

Kumanga mapuloteni a Plasma ndi 94.2%. V_d - pafupifupi 25 l (0.35 l / kg kulemera kwa thupi).

Zimapangidwa mu chiwindi ndikupanga 8 metabolites. Metabolite yayikulu ilibe mphamvu ya hypoglycemic, koma imakhudza ma microcirculation.

T_1/2 - Maola 12. Amapukusidwa makamaka ndi impso mu mawonekedwe a metabolites, osakwana 1% omwe amaponyedwa mkodzo osasinthika.

Kutulutsa Fomu

Mapiritsi osintha osinthika ndi oyera, oblong, olembedwa mbali zonse ziwiri: kumbali yake pali chizindikiro cha kampaniyo, inayo - "DIA30".

Omwe amathandizira: calcium hydrogen phosphate dihydrate, maltodextrin, hypromellose, magnesium stearate, anhydrous colloidal silicon dioxide.

30 ma PC - matuza (1) - mapaketi a makatoni.
30 ma PC - matuza (2) - mapaketi a makatoni.

Kuchita

Mphamvu ya hypoglycemic ya gliclazide imatha kugwiritsidwa ntchito nthawi imodzi ndi ma pyrazolone ofanana ndi ena, salicylates, phenylbutazone, antibacterial sulfonamide mankhwala, theophylline, caffeine, MAO zoletsa.

Kugwiritsa ntchito munthawi yomweyo kwa osagwiritsa ntchito beta-blockers kumawonjezera mwayi wokhala ndi hypoglycemia, ndipo amathanso kuvala tachycardia ndi kugwedeza kwamanja, chizindikiritso cha hypoglycemia, pomwe thukuta limakulirakulira.

Ndi munthawi yomweyo kugwiritsa ntchito gliclazide ndi acarbose, zotsatira zowonjezera za hypoglycemic zimawonedwa.

Cimetidine imachulukitsa kuchuluka kwa gliclazide mu plasma, komwe kumayambitsa kwambiri hypoglycemia (kupsinjika kwa CNS, kusokonezeka kwa chikumbumtima).

Pogwiritsa ntchito munthawi yomweyo ndi GCS (kuphatikizapo mitundu ya mankhwala ogwiritsira ntchito kunja), okodzetsa, barbiturates, estrogens, progestin, mankhwala osakanikirana a estrogen-progestogen, diphenin, rifampicin, mphamvu ya hypoglycemic ya glyclazide yafupika.

Zotsatira zoyipa

Kuchokera pamatumbo am'mimba: kawirikawiri - anorexia, nseru, kusanza, kutsegula m'mimba, kupweteka kwa epigastric.

Kuchokera ku hemopoietic system: nthawi zina - thrombocytopenia, agranulocytosis kapena leukopenia, kuchepa magazi (nthawi zambiri kumatha kusintha).

Kuchokera endocrine dongosolo: ndi bongo - hypoglycemia.

Thupi lawo siligwirizana: zotupa pakhungu, kuyabwa.

Type 2 shuga mellitus osakwanira mutha kudya mankhwala, zolimbitsa thupi ndi kuchepa thupi.

Kupewa mavuto amtundu wachiwiri wa matenda a shuga: kuchepetsa chiopsezo cha microvascular (nephropathy, retinopathy) ndi macrovascular complication (myocardial infarction, stroke).

Malangizo apadera

Gliclazide imagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe samatengera insulin kuphatikiza ndi zakudya zama calorie ochepa, zama carb ochepa.

Pa chithandizo, muyenera kuwunika kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya, kusinthasintha kwa tsiku ndi tsiku m'magazi a shuga.

Pankhani ya chithandizo cha opaleshoni kapena kuwonongeka kwa matenda a shuga, ndikofunikira kulingalira kuti mwina mungagwiritse ntchito insulin pokonzekera.

Ndi chitukuko cha hypoglycemia, ngati wodwalayo akudziwa, shuga (kapena yankho la shuga) amapatsidwa mkati. Pofuna kutaya chikumbumtima, glucose wamitsempha kapena glucagon sc, intramuscularly kapena kudzera m'mitsempha amathandizira. Pambuyo podziwikanso, ndikofunikira kuti wodwalayo adye chakudya chamagulu ambiri kuti mupewe kukonzanso kwa hypoglycemia.

Pogwiritsa ntchito munthawi yomweyo gliclazide yokhala ndi verapamil, kuyang'anira kuchuluka kwa shuga m'magazi kumafunika, ndi acarbose, kuyang'anira mosamala ndi kuwongolera kwa dongosolo lothandizira la hypoglycemic.

Kugwiritsa ntchito pamodzi gliclazide ndi cimetidine osavomerezeka.