Atoris mapiritsi analogues

Kugwiritsa ntchito Atoris (kapena ma analogues), zotsatira zabwino kwambiri zimatha kuchitika pa matenda a hyperlipidemia ndi matenda a mtima. Mankhwala ena amagwiritsidwa ntchito poletsa zinthu izi mwa anthu opitilira zaka 55. Atoris ndiyothandiza kwambiri, chifukwa chake muyenera kulingalira za mawonekedwe ogwiritsira ntchito, komanso kutchukitsa kwa othandizira ake otsika mtengo. Izi zimaphatikizapo mankhwala monga Lipoford, Atomax, ndi Atorvastatin. Zofananira zotchulidwa za mankhwala ndi Atoris omwe ali ndi kapangidwe kake kazinthu - atorvastatin calcium.

Kufotokozera mwachidule za Atoris

Mapiritsi a Atoris amapezeka m'matumba okhala ndi mulingo wa 10, 20, 30, 40, 60 kapena 80 mg. Ichi ndi mankhwala a statin omwe amachita mwanjira inayake. Calcium ya Atorvastatin imathandizira kuchepetsa ntchito ya enzyme, yomwe imathandiza kwambiri pakusintha kwa HMG-CoA kukhala mevalonic acid. Kutsilira kwa kusinthaku kumamanga ma cell a cholesterol oyipa, kuwachotsera ziwiya. Izi zimachepetsa kuchuluka kwa cholesterol ya LDL m'magazi.

Mapiritsi a Atoris ali ndi anti-atherosulinotic zotsatira, zomwe zimadziwonetsera pokha pazochitika zazikuluzikulu zamitsempha yamagazi ndi zigawo zamagazi.

Zotsatira zabwino za atorvastatin pamitsempha yamagazi zimatsimikiziridwa ndikumakanikiza kapangidwe kake ka isoprenoids, komwe kumachepetsa mwayi wowonjezera zamkati mwawo, zomwe zikutanthauza kuchepa kwa mipata yawo.

Pakati pa malingaliro onse omwe amamwa mankhwalawa, zotsatirazi zimatha kusiyanitsidwa:

1. Kutsatira kwambiri zakudya (isanayambe komanso mkati mwamankhwala) kumathandizira kuchepetsa lipids ya magazi.
2. Mankhwala ayenera kumwedwa nthawi yomweyo 1 patsiku.
3. Ndikofunikira kuwunika nthawi zonse zowonetsa chiwindi.
4. Ndi kukula kwa kupweteka kwa minofu kapena kufooka kwa chikhalidwe chosadziwika, chotsatira ndi malungo, tikulimbikitsidwa kuti musiye kumwa Atoris ndi kukaonana ndi dokotala.
5. Atoris imalekanitsidwa mu ana, komanso azimayi panthawi ya mkaka ndi pakati.
6. Zina mwazomwe zimatsutsana ndi kulephera kwa chiwindi, matenda enaake a m'matumbo.
7. Pankhani ya ziwengo kumodzi mwa zigawo za mankhwalawa, kayendetsedwe kake sikulimbikitsidwanso.
8. Mosamala kwambiri muyenera kutengera odwala omwe ali ndi chidakwa.

Pakatha milungu iwiri ya chithandizo, cholesterol yamagazi imatsika. Izi ziwoneka mu kusanthula. Kuchuluka kwake kumatha kumveka pambuyo pa masiku 25-30. Zotsatira zochizira pamankhwala zimakhala zokhazikika pokhapokha kumaliza maphunziro onse adokotala. Poterepa, mulingo wa mankhwalawa udzakhazikika ndi kuchuluka kwa cholesterol ya LDL m'magazi komanso kuopsa kwa matendawa.

Zomwe amagwiritsidwa ntchito ndi mankhwala analog Lipoford

Lipoford ndi waku India ndipo ndi analogue yotsika mtengo ya Atoris. Mankhwala amapezeka mu mawonekedwe a mapiritsi ndi ndende ya yogwira 10 kapena 20 mg. Lipoford ndi gulu laling'ono la kuchepetsa lipid lomwe limagwiritsidwa ntchito popewa komanso kuchiza matenda amtima oyambitsidwa ndi cholesterol yayikulu.

Kulunjika kwa zochita za Lipoford ndi Atoris kuli kofanana, chifukwa onsewa ndi calcium atorvastatin monga chinthu chachikulu chogwiritsa ntchito. Koma m'malo mwa Atoris ndi generic wotsika mtengo, ndikofunikira kufunsa dokotala yemwe adakulangizani chithandizo.

Chizindikiro chakugwiritsa ntchito Lipoford chikhoza kukhala chimodzi mwazinthu:

• kuchuluka kwa mafuta m'thupi,
• kuchuluka LDL cholesterol
• kuchuluka kwa magazi a apolipoprotein B ndi triglycerides,
• chachikulu, heterozygous achibale komanso osakhala achibale (ngati LDL cholesterol ndi yokwera kwambiri),
• homozygous achibale hypercholesterolemia,
• Hyperlipidemia
• mkulu seramu triglyceride woipa,
• dysbetalipoproteinemia,
• matenda a mtima
• chiwopsezo chotenga matenda a mtima: ukalamba, kusuta kwa chikonga, matenda ashuga, ndi zina zambiri.

Mukamagwiritsa ntchito Lipoford, muyenera kutsatira zakudya zapadera. Zakudya zopatsa thanzi ziyenera kukhazikitsidwa ndi mbale komanso zakudya zochepa.

Atomax ndi genor Atoris wina

Atomax ndi malo ena a Indian Atoris okhala ndi mtengo wotsika mtengo. Fomu yotulutsidwa ndi yomweyo. Mapiritsi amapezeka mu mitundu iwiri yokha: 10 ndi 20 mg. Gawo lalikulu la Atomax ndi atorvastatin calcium calcium. Kuphatikizikako kumaphatikizapo pafupifupi magawo khumi, kuphatikiza lactose, crospovidone, wowuma, etc.

Atomax amatengedwa pakamwa, ngakhale chakudyacho. Mankhwalawa amaphatikizidwa bwino, ndipo patatha maola awiri ndi awiri pazoyambira zambiri pazogwiritsa ntchito zimawonedwa m'magazi.

Contraindrum pakutenga Atomax akhoza kukhala:

• ziwopsezo zomwe zimapangidwa mu mankhwala,
• mimba nthawi iliyonse
• yoyamwitsa
• kuchuluka kwa matenda a chiwindi,
• kuchuluka kwa seramu transaminase ntchito,
• zaka za ana
• uchidakwa
• matenda aliwonse a chiwindi (gwiritsani ntchito mankhwalawa mosamala ndipo nthawi zonse amayang'aniridwa ndi dokotala),
• kusokoneza electrolyte bwino,
• mavuto mu endocrine dongosolo,
• kuchuluka kwa matenda opatsirana (mwachitsanzo, sepsis),
• opareshoni, etc.

Chinthu chachikulu chomwe wodwala ayenera kukumbukira: Atomax yokhala ndi cholesterol angagwiritsidwe ntchito, koma pokhapokha ngati adokotala adauza. Izi ndichifukwa choti ndi Mlingo wosayenera, mwayi wokhala ndi zovuta zingapo umawonjezeka kangapo.

Wolowa m'malo mwa Atorvastatin

Mwa mankhwala apakhomo omwe angalowe m'malo mwa Atoris, mankhwala amagawidwa omwe ali ndi dzina mogwirizana ndi chinthu chachikulu chomwe amagwira - Atorvastatin. Zimawononga zochepa poyerekezera ma Atoris onse, monga zimapangidwira ku Russian Federation osati kunja. Koma pankhani yothandiza, mankhwalawa salinso oyipa. Mapiritsi amapangidwa ndi mawonekedwe osiyanasiyana a yogwira: 1040 mg.

Mtunduwu umatha kutumikiridwa kuzizindikiro zofanana ndi zomwe tafotokozazi, popeza kapangidwe kake kamafanana. Zina mwazinthu zazikulu zomwe zimakhudzana ndi kubala ndi kuyamwitsa, kuyamwitsa, matenda a chiwindi mu siteji yovuta kwambiri, komanso tsankho la munthu aliyense.

Zina mwazotsatira zoyipa:

• kugona kusokonezedwa
• mutu
• kuphwanya chopondapo (kutsegula m'mimba, kudzimbidwa),
• nseru
• kuchuluka kwa mpweya m'matumbo,
• general malaise
• kupweteka kumbuyo
• kukokana
• zotupa pakhungu, etc.

Ngati cholesterol imakwezedwa, chidachi chithandiza kuthana ndi vutoli, koma malinga ndi mlingo woyenera. Chifukwa chake, ndikofunikira kutsatira njira zochizira zopangidwa ndi adokotala. Ngati mankhwala osokoneza bongo, mankhwalawa amasiya. Kuyamwa pambuyo pake kumatha kupewedwa ndikutsuka m'mimba, kumwa mankhwala ofewetsa thukuta kapena zina. Kuphatikiza apo, adotolo atha kukulemberani mankhwala othandizira, omwe angapangidwe ndikuwunika ndikuyang'anira ntchito zofunika.

Cheker Atoris Substitutes

Analogue ndiyotsika mtengo kuchokera ku ma ruble 250.

Cholowa ichi chimapangidwa ku Russia, motero chimakhala chochepa kwambiri kuposa "mankhwalawa". Ili ndi mndandanda womwewo wazisonyezo zakusankhidwa kwake. Contraindicated vuto la hypersensitivity mankhwala, chiwindi matenda, pa mimba ndi mkaka wa m`mawere.

Analogue ndiotsika mtengo kuchokera ku ma ruble 211.

Wopanga: Oxford (India)
Kutulutsa Mafomu:

• 20 mg mapiritsi, 30 ma PC.

Mankhwala ena ozikidwa ndi calcium atorvastatin mu piritsi. Kapangidwe ka Lipoford sikusiyana kwambiri ndi Atoris, chifukwa chake, zikuwonetsa, zotsutsana ndi zotsatira zoyipa zimakhala zofanana.

Atomax (mapiritsi) → mmalo mwake: 127 Pamwamba

Analogue ndiyotsika mtengo kuchokera ku ma ruble 179.

Wopanga: Hetero Drags Limited (India)
Kutulutsa Mafomu:

• 20 mg mapiritsi, 30 ma PC.

Atomax ndi cholowa m'malo mwa India cha Atoris okhala ndi mawonekedwe omwewo amasulidwe. Zimagwiranso ntchito kwa lipid-kuchepetsa mankhwala ndikugwiritsa ntchito DV yomweyo. Contraindicated pa mimba ndi mkaka wa m`mawere. Zotsatira zoyipa ndizotheka, kukambirana ndi dokotala ndikofunikira.

Analogs popanga ndi chisonyezo chogwiritsidwa ntchito

Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa Atoris olowa m'malo, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito

Analogs mwa chisonyezo ndi njira yogwiritsira ntchito

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa ndikugwiritsa ntchito njira

Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?

Kuti mupeze chiwonetsero chotsika mtengo cha mankhwala, chofananira kapena chofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezo zomwe zikugwira komanso zomwe zikugwiritsidwa ntchito. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.

Zotsatira za pharmacological

Atorvastatin ndi wothandizira wa hypolipidemic kuchokera pagulu la ma statins. Njira yayikulu yogwirira ntchito ya atorvastatin ndikulepheretsa ntchito ya HMG-CoA reductase, enzyme yomwe imathandizira kutembenuka kwa HMG-CoA kukhala mevalonic acid. Kusintha uku ndi limodzi mwamagawo oyambira kwambiri a cholesterol (cholesterol) kaphatikizidwe m'thupi. Atorvastatin kuponderezana kwa cholesterol synthesis kumabweretsa kuwonjezereka kwa ma LDL receptors mu chiwindi, komanso mu ziwopsezo zowonjezera minyewa. Ma receptor amenewa amamanga tinthu tating'ono ta LDL ndikuwachotsa m'madzi a m'magazi, zomwe zimapangitsa kuchepa kwa kuchuluka kwa LDL-C m'magazi.

Mphamvu ya antiatherosulinotic ya atorvastatin ndi chifukwa cha momwe imakhudzira makoma amitsempha yamagazi ndi zigawo zamagazi. Atorvastatin linalake ndipo tikulephera kapangidwe ka isoprenoids, omwe ndi zinthu zomwe zimapanga kukula kwamitsempha yamagazi. Mothandizidwa ndi atorvastatin, kuchuluka kwa magazi a endothelium kumatheka, kuchuluka kwa cholesterol-LDL, apolipoprotein B, triglycerides (TG) kumachepa, kuchuluka kwa cholesterol-HDL ndi apolipoprotein A kumachulukitsa.

Atorvastatin amachepetsa mamasukidwe akayendedwe amwazi ndi ntchito zina zophatikizika ndi kuphatikizira kwa maselo. Chifukwa cha izi, imakonza hemodynamics ndipo imasintha mkhalidwe wamathandizo. HMG-CoA reductase inhibitors imakhudzanso kagayidwe ka macrophages, kutseka kutsegulira kwawo ndikutchingira kupasuka kwa zolembera za atherosulinotic.

Monga lamulo, achire zotsatira za atorvastatin amakula pambuyo pa masabata awiri ogwiritsidwa ntchito ndi Atoris®, ndipo mphamvu yakeyo imatheka pambuyo pa masabata anayi.

Momwe zimachepetsa chiopsezo chokhala ndi mavuto a ischemic (kuphatikiza imfa ya myocardial infarction) ndi 16%, chiwopsezo chogonekedwanso kuchipatala cha angina pectoris, limodzi ndi zizindikiro za myocardial ischemia, ndi 26%.

• Kuchulukana kwa kuchuluka kwa cholesterol, cholesterol-LDL, apolipoprotein B ndi triglycerides mu magazi seramu ya odwala omwe ali ndi hyperlipidemia (mitundu ya Fredrickson IIa ndi IIb), kuphatikizapo polygenic hypercholesterolemia, achibale a heterozygous hypercholesterolemia ndi hypercholesterolemia wosakanikirana.
• Kuchepetsa kwambiri kuchuluka kwa cholesterol, cholesterol-LDL ndi apolipoprotein B odwala ndi homozygous achibale hypercholesterolemia.
• Atoris ® imachulukitsa kuchuluka kwa HDL-C mu seramu yamagazi ndikuchepetsa kuchuluka kwa LDL-C / HDL-C.
• Amagwiritsidwa ntchito ngati vuto losakwanira la mankhwala limathandizira komanso njira zina zochiritsira zopanda mankhwala.

Kuteteza Matenda a Mtima:

• Kupewera kwa mtima ndi vuto la mtima mwa odwala osakhala ndi matenda a mtima kuphatikiza motsutsana ndi maziko a dyslipidemia.
• Kupewera kwachiwiri kwamatenda amtundu wa mtima kwa odwala omwe ali ndi matenda a mtima kuti achepetse chiwerengero cha anthu omwalira, kulowerera m'mitsempha, matenda opha ziwalo, kuyambiranso kuchipatala kwa angina pectoris ndi kufunika kosinthanso.

Contraindication

• Hypersensitivity pazinthu zilizonse za mankhwala.
• Matenda a chiwindi omwe amagwira ntchito (kuphatikizapo hepatitis yayitali, matenda oopsa a chiwindi).
• Kulephera kwa chiwindi.
• Cirrhosis chiwindi cha etiology iliyonse.
• Kuwonjezeka kwa ntchito ya hepatic transaminases yachidziwitso osadziwika kuposa nthawi zitatu poyerekeza ndi VGN.
• Matenda a minofu.
• Lactase akusowa, lactose tsankho, shuga-galactose malabsorption syndrome.
• Mimba komanso nthawi yoyamwitsa.
• Zaka mpaka zaka 18 (zoyenera ndi chitetezo chogwiritsa ntchito sizinakhazikitsidwe).

Ndi chenjezo: uchidakwa, mbiri yakale ya matenda a chiwindi.

Mimba komanso kuyamwa

Atoris ® imaphatikizidwa pakati pa nthawi yakhanda komanso yoyamwitsa. Kafukufuku wazinyama akuwonetsa kuti chiwopsezo kwa mwana wosabadwa chingadutse phindu lililonse kwa mayi.

Mwa amayi omwe ali ndi zaka zakubala omwe sagwiritsa ntchito njira zodalirika zakulera, kugwiritsa ntchito Atoris® sikulimbikitsidwa. Pokonzekera kukhala ndi pakati, muyenera kusiya kugwiritsa ntchito Atoris® osachepera mwezi umodzi musanakonzekere kutenga pakati.

Palibe umboni pakugawika kwa atorvastatin mkaka wa m'mawere. Komabe, mwa mitundu ina ya nyama, kuchuluka kwa atorvastatin m'mwazi ndi mkaka wa m'mawere ndikofanana. Ngati ndi kotheka kugwiritsa ntchito mankhwala Atoris® pa mkaka wa m`mawere, pofuna kupewa chiopsezo cha zovuta ana, kuyamwitsa kuyenera kuyimitsidwa.

Malangizo apadera

Asanayambe chithandizo ndi Atoris ®, wodwalayo ayenera kuthandizidwa kudziwa zakudya zoyenera zomwe azitsatira panthawi yonse ya chithandizo.

Kuwonjezeka kwa ntchito ya hepatic michere mu seramu yamagazi imatha kuwonedwa pamankhwala ndi Atoris®. Kuchulukaku nthawi zambiri kumakhala kocheperako ndipo sikutanthauza kufunikira kwamankhwala. Komabe, tikulimbikitsidwa kuwunika ntchito ya michere ya chiwindi mu seramu ya m'magazi musanalandire chithandizo, pakatha masabata 6 ndi 12 komanso ndi kuchuluka kwa atorvastatin. Ngati pali kuwonjezeka katatu pantchito ya ACT ndi / kapena ALT wachibale wa HBV, chithandizo ndi Atoris ® ziyenera kusiyidwa.

Atorvastatin ikhoza kuyambitsa kuwonjezeka kwa zochitika za CPK ndi aminotransferases.

Mwa amayi omwe ali ndi zaka zakubala omwe sagwiritsa ntchito njira zodalirika zakulera, kugwiritsa ntchito Atoris® sikulimbikitsidwa. Ngati wodwalayo akukonzekera kutenga pakati, ayenera kusiya kumwa Atoris® mwezi umodzi asanakonzekere kutenga pakati.

Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala nthawi yomweyo ngati ululu wosamveka kapena kufooka kwa minofu kumachitika. Makamaka ngati amatsagana ndi malaise kapena malungo.

Kuchiza ndi Atoris ® kungayambitse myopathy, yomwe nthawi zina imayendetsedwa ndi rhabdomyolysis, zomwe zimayambitsa kulephera kwa impso. Kuopsa kwa vutoli kumakulirakudya ndikumamwa kamodzi kapena zingapo mwa mankhwala otsatirawa ndi Atoris ®: zotumphukira za michere, niacin, cyclosporine, nefazodone, maantibayotiki ena, azole antifungals, ndi HIV proteinase inhibitors.

Mu mawonetseredwe azachipatala a myopathy, tikulimbikitsidwa kuti plasma wozama wa CPK utsimikizike. Ndi kuchuluka kwapakati pa 10 VHF wa ntchito ya KFK, chithandizo ndi Atoris ® ziyenera kuyimitsidwa.

Pali malipoti a kakulidwe ka atonic fasciitis ndi kugwiritsa ntchito atorvastatin, komabe, kulumikizana ndi kugwiritsa ntchito mankhwalawa ndizotheka, koma sikunatsimikizidwe, etiology sichikudziwika.

Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala ngati vuto lopanda kufooka kapena kufooka kwa minofu kumachitika, makamaka ngati akuphatikizidwa ndi malaise kapena malungo.

Atoris® imakhala ndi lactose, chifukwa chake kugwiritsidwa ntchito kwa odwala omwe ali ndi kuchepa kwa lactase, kusalolera kwa lactose ndi glucose-galactose malabsorption syndrome ndi kutsutsana.

Kukopa pa kuyendetsa magalimoto ndi kugwira ntchito ndi njira.

Popeza kuthekera kwa chizungulire, kusamala kuyenera kugwiritsidwa ntchito poyendetsa magalimoto ndi zida zina zamaukadaulo zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.

Piritsi limodzi lili:

Chithandizo: calcium wa atorvastatin 10,36 mg, (wofanana ndi 10 mg atorvastatin, motsatana).

Othandizira: povidone - 5.8 mg, sodium lauryl sulfate - 2.9 mg, calcium carbonate - 31.84 mg, MCC - 29 mg, lactose monohydrate - 57.125 mg, croscarmellose sodium - 7.25 mg, magnesium stearate - 0,725 mg.

Kanema wa Shell: Opadry II HP 85F28751 yoyera (polyvinyl mowa, titanium dioxide (E171), macrogol 3000, talc) - 4.35 mg.

Mlingo ndi makonzedwe

Mkati, ngakhale zakudya.

Asanayambe kugwiritsa ntchito mankhwala Atoris ®, wodwalayo ayenera kusinthidwa ku chakudya chomwe chimatsimikizira kuchepa kwa kuchuluka kwa lipids m'magazi, omwe amayenera kuwonedwa panthawi yonse ya mankhwalawa. Musanayambe chithandizo, muyenera kuyesa kuthandizira kuwongolera kwa hypercholesterolemia kudzera mu masewera olimbitsa thupi komanso kuchepa thupi kwa odwala omwe ali ndi kunenepa kwambiri, komanso chithandizo cha matenda oyambitsidwa.

Chithandizo chimayamba ndi mlingo woyambira 10 mg. Mlingo wa mankhwalawa umasiyana 10 mpaka 80 mg kamodzi patsiku ndipo umasankhidwa poganizira kuchuluka kwa LDL-C, cholinga cha mankhwala ndi chithandizo cha munthu.

Atoris® imatha kutengedwa kamodzi nthawi iliyonse patsiku, koma nthawi yomweyo tsiku lililonse. The achire zotsatira zimawonedwa pambuyo 2 milungu mankhwala, ndipo pazotheka zambiri pambuyo 4 milungu. Chifukwa chake, mankhwalawa sayenera kusinthidwa kale kuposa masabata anayi pambuyo pa kuyamba kwa mankhwalawo m'mbuyomu.

Kumayambiriro kwa mankhwalawa komanso / kapena pakukula kwa kuchuluka kwa mankhwalawa, ndikofunikira kuyang'anira kuchuluka kwa zamadzimadzi m'magazi a 2-5 aliwonse ndikuwongolera mlingo moyenera.

Hypercholegous cholowa ndi polygenic) hypercholesterolemia (mtundu IIa) ndi hyperlipidemia wosakanikirana (mtundu IIb): Chithandizo chimayamba ndi koyamba mlingo woyenera, womwe umawonjezereka pambuyo pa masabata anayi, kutengera momwe wodwalayo amayankhira. Mlingo wapamwamba tsiku lililonse ndi 80 mg.

Homozygous cholowa hypercholesterolemia: mulingo wofanana wa mankhwalawo ndi wofanana ndi mitundu ina ya Hyperlipidemia. Mlingo woyambirira amasankhidwa payekha, kutengera kuopsa kwa matendawa. Odwala ambiri omwe ali ndi homozygous cholowa hypercholesterolemia, amatha kugwiritsa ntchito mankhwalawa tsiku lililonse 80 mg (kamodzi). Atoris ® imagwiritsidwa ntchito ngati adjunctive Therapy njira zina zamankhwala (plasmapheresis) kapena chithandizo chachikulu ngati chithandizo chamankhwala ndi njira zina sichingatheke.

Magulu apadera a odwala.

Odwala okalamba.

Mwa odwala okalamba, mlingo wa Atoris® suyenera kusinthidwa.

Matenda aimpso.

Sizikhudzanso kuchuluka kwa atorvastatin mu madzi a m'magazi kapena kuchepa kwa kuchuluka kwa LDL-C kugwiritsa ntchito atorvastatin, chifukwa chake, kusintha kwa mankhwalawa sikofunikira.

Kuwonongeka kwa chiwindi.

Odwala omwe ali ndi vuto la chiwindi ntchito, kusamala ndikofunikira (chifukwa cha kutsika pang'ono pa mankhwalawa kuchokera mthupi). Muzochitika zotere, magawo azachipatala ndi a labotale ayenera kuyang'aniridwa mosamala (kuwunika pafupipafupi kwa ntchito ya ACT ndi ALT). Kukula kwakukulu kwa hepatic transaminases, mlingo wa Atoris® uyenera kuchepetsedwa kapena chithandizo chitha.

Gwiritsani ntchito limodzi ndi mankhwala ena.

Ngati ndi kotheka, munthawi yomweyo kugwiritsa ntchito cyclosporine tsiku lililonse mankhwala Atoris® sayenera upambana 10 mg.

Atoris - zambiri

Wothandizira wa hypolipidemic Atoris (Atoris) ndi gawo la gulu la ma statins omwe amalepheretsa ntchito ya enzyme mu chiwindi (HGM-CoA), yomwe imayang'anira kupanga cholesterol.

Mankhwala amapangidwa piritsi piritsi zosiyanasiyana 10 mg, 20 mg ndi 40 mg yogwira mankhwala a atorvastatin. Piritsi limodzi limakhala ndi ochulukirapo - povidone, sodium lauryl sulfate, magnesium stearate, lactose monohydrate, etc.

Limagwirira a zochita za mankhwala amagwirizana ndi kukakamiza kolesterol synthesis ndi kuchuluka kwa LDL zolandilira mu owonjezera minyewa ya chiwindi. Kenako, ma receptor amamanga tinthu tating'onoting'ono ta LDL, ndikuchotsa magaziwo. Chifukwa chake, kuchepa kwa cholesterol yamagazi.

Dokotala amamulembera Atoris mu zotere:

• odwala popanda matenda a mtima ofunikira kuti achepetse chiopsezo cha myocardial infarction, stroke, angina pectoris ndi kufunika kwa myocardial revascularization process,
• odwala omwe akudwala matenda a shuga osadalira insulin (mtundu 2) popanda matenda akuwonetsa matenda a mtima pofuna kuchepetsa mwayi wokhala ndi vuto la mtima komanso sitiroko.
• odwala omwe ali ndi matenda a mtima ofunikira kuti achepetse chiopsezo cha kufooka kwa mtima kosagwiritsa ntchito, matenda oopsa komanso osapweteka, angina pectoris, kufunikira kwa kusinthanso kwa myocardial ndi kuchipatala chifukwa cha kulephera kwa mtima,
• kuwonjezera pa zakudya zapadera zamagulu oyambira (achibale / osakhala a banja) ndi osakanikirana (mtundu IIa ndi IIb) hypercholesterolemia,
• monga chowonjezera pa zakudya za hypertriglyceridemia (mtundu IV), dysbetalipoproteinemia (mtundu III), komanso homozygous Famer hypercholesterolemia,
• odwala azaka za 10 mpaka 17 omwe ali ndi mbiri yakale ya matenda amtima kapena zambiri zopitilira kukula kwawo.

Atoris ali ndi zochepa zotsutsana. Pakati pawo, ndikofunikira kuwonetsa hypersensitivity pazigawo zam'mapiritsi, mimba ndi nthawi ya mkaka wa m`mawere, kukanika kwa chiwindi ndi milingo yayikulu ya transaminase.

Mitundu yotsika mtengo komanso yolowa m'malo mwa mankhwala a atoris a ana ndi akulu

Atoris ndi mankhwala ochokera kunja. Analogues otsika mtengo kuposa a Atoris ali ndi chinthu chomwecho kapena chofanana, amagwiritsidwa ntchito m'maiko osiyanasiyana, kuphatikiza opanga zoweta. Mankhwala pawokha ku Russia amalipira 400 - 1000 rubles. Kusintha kwamitengo kumeneku kumachitika chifukwa cha kusiyana kwa kuchuluka kwa mapiritsi a phukusi komanso kuchuluka kwake kwa zomwe zikugwira.

Zizindikiro zogwiritsidwa ntchito zimawonetsa kuti osagwiritsa ntchito mawu akuti hyperlipidemia samveka. M'malo mwake, izi zikutanthauza kuwonjezeka kwa milingo ya lipid yamagazi (mwachitsanzo, cholesterol imatha kutchedwa, koma pali zinthu zambiri), izi ndi zinthu zosiyanasiyana zosungunuka zomwe sizipezeka m'magazi ndipo zitha kupangitsa kuti magazi azigwera.

Kupezeka kwawo kumawonetsa kuphwanya mafuta kagayidwe. Mankhwala amtunduwu amatha kuchotsa lipids m'magazi ndikuchepetsa mulingo wawo.

Kuchuluka kwa yogwira mankhwala ndi koyenera kwa odwala omwe ali ndi magawo akuluakulu a matendawa.

Analogi opanga Russian

Zofananira zotsika mtengo zamankhwala opanga zoweta amatha kuthana ndi kuchuluka kwa mitundu ya lipid. Ndipo sikuti nthawi zonse mankhwala otsika mtengo amakhala osiyanasiyana pamakhalidwe. Pa tebulo lomwe lili pansipa tikulemba zomwe zimakonda kwambiri.

M'malo mwa Ukraine

Mndandanda wa ma analogu opangidwa ku Ukraine ali ndi kukonzekera kwachilengedwe. Kusinthanitsa ndi mankhwala otsika mtengo ndikofunikira mu magawo oyamba a matendawa kapena ngati chida chowonjezera.

1. Alfalfa anticholesterol. Mankhwalawa, opangidwa motengera gawo lachilengedwe, ndioyenera kwa achinyamata ndi achikulire. Chovomerezedwa ndi maphunziro. Amawononga ma ruble 210.
2. Aterovit. Zimathandizira kulimbitsa mitsempha yamagazi ndi cholesterol yotsika. Kapangidwe kamankhwala ndikachilengedwe. Amawononga ndalama zokwana ma ruble 140.
3. Cardiochistin. Amawerengera cholesterol yambiri. Amasintha thanzi ndi atherosulinosis. Kumwa mankhwalawo ndizoletsedwa pa nthawi ya pakati komanso pakubala. Amawononga ma ruble 200.
4. Omega Plus Complex. Gwero lathunthu la ma Omega acid amtundu 3 ndi 6. Matendawa amagwiranso ntchito ya mtima ndi mtima. Simalola mapangidwe magazi. Mankhwalawa ayesedwa. Mtengo ku Russia ndi ma ruble 330.
5. Dioscorea Kuphatikiza. Amachepetsa cholesterol ya magazi ndipo amachepetsa kuthamanga kwa magazi. Kuteteza mitsempha kuti isawonongeke. Zachilengedwe zonse. Zimawononga pafupifupi ma ruble 250.

Zojambula zaku Belarusi

Zojambula zama Belarusi ndizotsika mtengo. Awa ndi othandizira pafupi ndi zigawo zosiyanasiyana zomwe zimagwira ntchito mthupi mwake.

Zofanizira zina zakunja

Mankhwala ochokera kunja ndiokwera mtengo kwambiri. Njira zabwino zomwe zidasankhidwa pamlandu uliwonse ndi munthu payekha. Chisankhocho chimapangidwa bwino pamodzi ndi adotolo. Ma synorms a Ator ali ndi mawonekedwe awo.

• Vasilip. Amapangidwa ku Slovenia. Oyenera odwala omwe ali ndi matenda ashuga. Amachepetsa cholesterol, koma ndi zakudya. Kutengera kuchuluka kwa mapiritsi omwe ali phukusili, amatenga ndalama kuchokera ku ma ruble 160 mpaka 340.
• Zokor. Amapangidwa ku Netherlands. Kumwa mankhwalawo kumakhala koyenera ngati pali chiopsezo chotenga matenda a mtima. Mapiritsi amatenga ma ruble 750.
• Crestor. Wopangidwa ku UK. Oyenera odwala omwe ali ndi atherosulinosis kapena mitundu yosiyanasiyana ya hypercholesterolemia.Mtengo wa mankhwala osokoneza bongo osiyanasiyana amasiyana 700 mpaka 3600 rubles.
• Rosulip. Zopangidwa ku Hungary. Simalola mapangidwe a cholesterol amana. Amatulutsidwa pokhapokha ngati akuwapatsa mankhwala. Mlingo wosiyanasiyana wa mapiritsi umakhala kuchokera 700 mpaka 1200 rubles.
• Mertenil. Amapangidwa ku Hungary. Zokhudza ana omwe ali ndi mankhwalawa sizinaphunzire ndipo zimaletsedwa kuti aziwapatsa ana. Mitengo yosiyanasiyana ikugulitsidwa, mtengo wawo umayamba kuchokera ku ma ruble 700 ndikufika ku ruble 1400.
• Rosucard. Czech Republic The zikuchokera mankhwala zikuphatikiza yogwira mankhwala rosuvastatin. Kugwiritsa ntchito kumatheka pokhapokha ngati dokotala amuika. Mankhwala ochepetsedwa ndi mtengo wotsika mtengo, mtengo wake sapitilira ma ruble 500.

Momwe mungachotsere atoris ndizosavuta kuthetsa. Pali mitundu yambiri. Mitengo yawo ndiosiyana, mndandanda wazowonetsa ndiwosiyana, pali mankhwala omwe ali ndi zovuta zingapo pakhungu, pali omwe amawongoleredwa.

Mankhwala ofunikira amasankhidwa bwino mutatha maphunziro angapo othandizira labotale kapena zamankhwala.

Mapiritsi a Atoris: malangizo ogwiritsira ntchito, mavuto, analogues, mtengo, ndemanga

Mankhwala Atoris, malangizo ogwiritsira ntchito omwe amaperekedwa kwa owerenga athu, ali m'gulu la mankhwala ochepetsa lipid, omwe ndi m'badwo wachitatu wama statins - mankhwala omwe amathandiza kuchepetsa kuchuluka kwa otsika lipoproteins (LDL) - omwe amadziwika kuti "cholesterol yoyipa" - m'magulu am'mimba, michere ndi malo okhala ( magazi, lymph, madzimadzi okhathamira, zotumphukira ndi zotumphukira) m'thupi la munthu.

Kugwiritsa ntchito mankhwala amtunduwu kumachepetsa mwayi wamatenda amtima pakati pa anthu azaka zapakati, ngakhale kuti anthu omwe ali ndi zaka zopitilira 70 sanatchulidwe choncho.

Chipangizocho chikuvomerezedwa kuti chizigwiritsidwa ntchito pokhapokha ngati njira zopewera (kutsatira kwambiri mafuta a cholesterol, kuchita masewera olimbitsa thupi pafupipafupi komanso njira zochepetsera thupi) sizinathandize kuti matenda a lipid kagayidwe.

Zambiri pazomwe zimapangidwira, mawonekedwe omasulira ndi ma CD

Atoris ali ndi mawonekedwe amodzi Mlingo ndipo amapezeka mwanjira yoyera - pang'ono ndi biconvex - mapiritsi ozungulira okhala ndi filimu yovindikira. Zomwe zimagwiritsa ntchito mankhwalawa ndi atorvastatin.

Zomwe zili papiritsi lililonse zitha kukhala: 10, 20, 30, 40, 60 ndi 80 mg.

Zina mwa zomwe zimapangidwira zimapangidwira:

• Microcrystalline mapadi,
• Sodium lauryl sulfate,
• Magnesium wakuba,
• Calcium calcium
• Lactose conohydrate,
• Povidone
• Crospovidone
• Croscarmellose sodium.

Mtundu wamafilimu a Opadry II wapangidwa kuchokera:

• Talc,
• Titanium dioxide (chakudya E171),
• Polyethylene glycol (m'malo ena amatchedwa macrogol-3000 kapena chakudya chowonjezera E1521),
• Mowa wa Polyvinyl.

Pakatikati pa piritsi pali cholakwika ngati mbewa loyera komanso loyera. Mapaketi amtundu wa Contour cell (matuza) okhala ndi mapiritsi amayikidwa mkati mwa makatoni.

Kutengera ndi kachulukidwe ka zinthu zomwe zimagwira, paketi iliyonse ikhoza kukhala ndi mapiritsi khumi mpaka makumi asanu ndi anayi. Malangizo ogwiritsira ntchito ayenera kukhazikitsidwa phukusi lililonse ndi mankhwalawo.

Zolemba za Pharmacodynamics

Mankhwala a atoris, omwe ali m'gulu la ma statins, ali ndi mphamvu yotsitsa lipid chifukwa cha kuthekera kwa gawo lomwe limagwira, atorvastatin, kuletsa (kuchepetsa) ntchito ya enzyme yapadera (HMG-CoA reductase), yomwe imatenga gawo loyamba la cholesterol synthesis yochitika ndi maselo a chiwindi (hepatocytes )

Chifukwa cha kulowererapo kwa atorvastatin, kuchuluka kwa cholesterol yomwe imapangidwa ndi hepatocytes imachepetsedwa kwambiri, ndikupatsa chidwi kuyambira pachiwonjezero chowonjezera cha chiwerengero cha LDL cholandila komanso kugwiritsidwa ntchito kwa munthawi yomweyo kugwiritsidwa ntchito kwa lipoprotein cholesterol yomwe ilipo m'magazi.

Pankhaniyi, kagayidwe ka lipoprotein, kamene kamakhala ndi apolipoprotein - apoB mapuloteni, omwe ali ndi cholesterol "yoyipa" ndipo amadziwika ndi LDL receptors of cell chiwindi, nawonso amakula.

Zotsatira zamachitidwe omwe ali pamwambapa, zidutswa za milomo yochepa ya m'mimba, zomwe zimamangidwa, patapita nthawi zimachotsedwa m'madzi a m'magazi, zomwe zikutanthauza kuti zimadziwikanso zokha.

Zotsatira zake zimachitika:

• Kuponderezedwa kwa kubwezeretsa zinthu zachilengedwe - isoprenoids yopangidwa m'thupi la munthu kuchokera ku acetic
• Acids ndi kukula-kolimbikitsa maselo nyumba kupanga intravascular nembanemba,
• Kulimbitsa kupumira kotengera kwa endothelium
• Kutsitsa ma triglycerides, mapuloteni a apoB ndi cholesterol otsika kwambiri.
• Kuwonjezeka kwa kuchuluka kwa apolipoprotein AI (apoA-I protein) ndi lipoproteins wambiri, omwe amakhala ndi "cholesterol yabwino",
• Kuchepetsa magazi m'madzi
• Kutha kwa machitidwe a coagulation ndi gluing (kuphatikiza) a mapulateleti,
• Kuwongolera hemodynamics (kuyenda kwa magazi kudzera machitidwe amitsempha yamagazi kuchokera kumalo othamanga mpaka kumalo otsika),
• Matenda a magazi
• Kuletsa ntchito zochulukirapo za macrophages (ma cell omwe amayang'anira kugwira ndi kukonza mabakiteriya, maselo akufa ndi ma cell tinthu tachilendo kwa thupi), zomwe zimathandiza kupewa kuwononga mawonekedwe omwe amatchedwa atherosranceotic plaques.

Zotsatira zoyambirira za kuwonetsa atorvastatin zimawonedwa patatha milungu iwiri atamwa mankhwalawo, kufikira pazofunikira kwambiri mwezi umodzi. Muzochita zamankhwala, zidatsimikiziridwa kuti atoris ndi piritsi yomwe mungachepetse kwambiri zovuta za ischemic, kufunikira kokonzanso kuchipatala kwa odwala ndi kuchuluka kwa omwalira.

Pharmacokinetics

• Pazitali zabwino za mankhwala a atoris m'madzi am'magazi zimawonedwa patatha maola 1-2 mutatha kumwa mapiritsi.
• Pharmacokinetics ya atorvastatin sizitengera kaya amuna kapena akazi kapena msinkhu wa odwala.
• Zinapezeka kuti mthupi la odwala omwe ali ndi vuto la chiwongola dzanja cha chiwindi, kuchuluka kwa kuchitika kwa kuchuluka kwambiri kwa atorvastatin kungakhale kokwanira kakhumi ndi kasanu ndi kawiri kuposa masiku onse.
• Mukatha kudya, kuchuluka kwa mayamwidwe (mayamwidwe) a mankhwalawa kumacheperachepera, ngakhale mulingo wochepetsetsa wa lipoprotein cholesterol sukusintha konse.
• The bioavailability ya atorvastatin, yomwe imadutsa chiwindi choyamba cha wodwalayo, imakhala yotsika: sioposa 12% (izi zikufotokozedwa ndi kukula kwa njira ya metabolic). Mwa dongosolo bioavailability wa inhibitory zotsatira za atorvastatin pa HMG-CoA reductase ali pafupi 30%.
• Chibale chomwe chimagwira ntchito ya mankhwala atoris okhala ndi mapuloteni am'madzi ndi 98%.
• Atorvastatin sichitha kuthana ndi chotchinga cha magazi, ubongo wake umachitika makamaka m'magawo a chiwindi chifukwa cha kuwonekera kwa cytochrome P4503A4. Ma metabolac metabolic omwe amagwira ntchito chifukwa cha njirayi amapereka gawo lalikulu (pafupifupi 70%) la mankhwala a Atoris, omwe amakhala kwa maola makumi awiri ndi atatu.
• Hafu ya moyo wa mankhwalawa ndi pafupifupi maola khumi ndi anayi. Ambiri mwa mankhwalawa amachoka m'thupi la wodwalayo ndi bile, yaying'ono pang'ono (pafupifupi 45%) - yokhala ndi ndowe. Ndi mkodzo, osapitilira 2% ya mankhwalawa amachotsedwa.

Atoris - analogues

Kuti muchepetse kuchuluka kwa triglycerides, lipids ndi cholesterol m'madzi a m'magazi, ma statins ndi omwe amapatsidwa. Atoris amatanthauzanso - fanizo la mankhwalawa limafunikira kuti pakhale kusagwirizana ndi mankhwalawa kapena ngati, pazifukwa zina, sizingatheke kuti mugule. Ndizofunikira kudziwa kuti zamagetsi ambiri ndi zotsika mtengo kwambiri.

Mndandanda wa mankhwala Atoris

Kukonzekera komwe kumapangidwira kumapangidwa pamaziko a calcium a atorvastatin - chinthu chopangidwa kuti chichepetse kuchuluka kwa lipids m'magazi. Atoris imapanganso mphamvu ya anti-sclerotic pamakoma amitsempha yamagazi, imachepetsa mamvekedwe a plasma ndi kachulukidwe, imapangitsa hemodynamics, ndikuchepetsa mwayi wokhala ndi matenda amtima.

Mankhwala otsatirawa ali ndi vuto lofanananso ndi mawonekedwe:

• Torvalip
• Tulip
• Torvas
• Liptonorm,
• Torvacard
• TG-tor
• Torvazin
• Atorvastatin
• Liprimar
• Atorvox
• Lipoford
• Vazator
• Lipona
• Amvastan
• Astin
• Atocor
• Atorvacor
• Atotex
• Atorvasterol,
• Atormak
• Lipodemin,
• Limistin
• Lipimax
• Vasocline
• Livostor
• Torvazin
• Lithuania,
• Tolevas
• Etset,
• Torzaks,
• Actastatin
• Abender
• Aztor
• Liperosis
• Storvas
• Escolan
• Emstat
• Torvadak
• Lipitin
• Atrok.

Ndiziti zomwe zimagwira ntchito bwino komanso zimagwira bwino - Atoris kapena Torvakard?

Mankhwala onse omwe amawunikiridwa amatengera gawo limodzi lomweli, kuphatikiza kwa zosakaniza zina ndizofanana. Akatswiri a mtima amakhulupirira kuti palibe kusiyana kwakukulu pakati pa mankhwalawo, kusiyana kokhako pamtengo ndikuti Torvard ndiyotsika mtengo pang'ono, ngakhale pazigawo zazikulu (40 mg).

Chili bwino kugula - Atorvastatin kapena Atoris?

Mankhwalawa alinso ndi mawonekedwe ofanana, mawonekedwe omasulidwa komanso zomwe zili pazinthuzo. Atorvastatin amakonda kwambiri, chifukwa amalolera bwino ndipo amayambitsa zotsatira zoyipa zochepa. Potere, wothandizirayo ndi wokwera mtengo kwambiri kuposa Atoris, yemwe akufotokozedwa ndi muyeso wambiri wa kuyeretsa kwa zosakaniza zam'mapiritsi.

Krestor kapena Atoris - chiri bwino ndi chiani?

Chithandizo choyamba chomwe chikuwonetsedwa chimachokera ku chinthu china - rosuvastatin. Amagwira ntchito mofanananso ndi Atoris, koma amaganiza mlingo wocheperako, popeza 5 mg ya rosuvastatin imafanana ndi mphamvu ya 10 mg ya atorvastatin.

Chifukwa chake, Krestor amaonedwa ngati mankhwala osavuta kwambiri, omwe angathe kumwedwa nthawi zambiri. Nthawi yomweyo, imawononga ndalama zambiri kuposa Atoris, pafupifupi nthawi 2.5.

Atoris kapena Liprimar yogwira mtima kwambiri, ndipo ndibwino kugula chiyani?

Mankhwala ofanana amapangidwa pamaziko a atorvastatin. Mwa zabwino za Liprimar ndikofunikira kuzindikira:

• kuchuluka kwa Mlingo (10, 20, 40 ndi 80 mg),
• kuyeretsa kwapamwamba kwambiri kwa zosakaniza, zomwe zimapereka chiopsezo chochepa cha mavuto,
• kulekerera kwabwino
• mkulu bioavailability ndi digestibility.

Komabe, Liprimar sichimawerengedwa chifukwa cha mtengo wokwera kwambiri, imakwezeka maulendo 4.5 kuposa Atoris.

Kodi ndibwino kumwa chiyani - Atoris kapena Simvastatin?

Mankhwala omwe ali ndi mankhwalawa ali ndi zosakaniza zosiyanasiyana zogwira ntchito, ndipo kuti mukwaniritse zochizira zofunika za simvastatin, 20 mg imafunika, pomwe atorvastatin imafunikira 10 mg.

Palibe kusiyana pakati pa mankhwala, kupatula mtundu wawo. Atoris imakhala yokwera kanayi kuposa pamenepa. Mukamasankha pakati pa iwo ndi Simvastatin ndikofunikira kuganizira za wodwala, kupezeka kwa matupi awo sagwirizana ndi hypersensitivity pamagulu a mankhwalawo.

Roxer kapena Atoris - chiri bwino ndi chiani?

Kuphatikizika kwa mankhwalawa kumasiyananso, roxuvastatin ndiye maziko a Roxers. Monga tawonetsera kale, mankhwalawa ndi abwino, chifukwa amagwira ntchito kwambiri, safunikira kayendedwe ka pafupipafupi komanso mlingo waukulu. Madokotala ambiri amamulembera Roxer pafupipafupi, chifukwa mankhwalawa, kuwonjezera pa kugwiranso ntchito, amakhala okwera mtengo kwambiri, amakhala otsika mtengo kuposa 2 Atoris.

Atoris analogues ndi mitengo

Asanayambe chithandizo ndi Atoris ®, wodwalayo ayenera kuthandizidwa kudziwa zakudya zoyenera zomwe azitsatira panthawi yonse ya chithandizo.

Kuwonjezeka kwa ntchito ya hepatic michere mu seramu yamagazi imatha kuwonedwa pamankhwala ndi Atoris®. Kuchulukaku nthawi zambiri kumakhala kocheperako ndipo sikutanthauza kufunikira kwamankhwala.

Komabe, tikulimbikitsidwa kuwunika ntchito ya michere ya chiwindi mu seramu ya m'magazi musanalandire chithandizo, pakatha masabata 6 ndi 12 komanso ndi kuchuluka kwa atorvastatin.

Ngati pali kuwonjezeka katatu pantchito ya ACT ndi / kapena ALT wachibale wa HBV, chithandizo ndi Atoris ® ziyenera kusiyidwa.

Atorvastatin ikhoza kuyambitsa kuwonjezeka kwa zochitika za CPK ndi aminotransferases.

Mwa amayi omwe ali ndi zaka zakubala omwe sagwiritsa ntchito njira zodalirika zakulera, kugwiritsa ntchito Atoris® sikulimbikitsidwa. Ngati wodwalayo akukonzekera kutenga pakati, ayenera kusiya kumwa Atoris® mwezi umodzi asanakonzekere kutenga pakati.

Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala nthawi yomweyo ngati ululu wosamveka kapena kufooka kwa minofu kumachitika. Makamaka ngati amatsagana ndi malaise kapena malungo.

Kuchiza ndi Atoris ® kungayambitse myopathy, yomwe nthawi zina imayendetsedwa ndi rhabdomyolysis, zomwe zimayambitsa kulephera kwa impso.

Kuopsa kwa vutoli kumakulirakudya ndikumamwa kamodzi kapena zingapo mwa mankhwala otsatirawa ndi Atoris ®: zotumphukira za michere, niacin, cyclosporine, nefazodone, maantibayotiki ena, azole antifungals, ndi HIV proteinase inhibitors.

Mu mawonetseredwe azachipatala a myopathy, tikulimbikitsidwa kuti plasma wozama wa CPK utsimikizike. Ndi kuchuluka kwapakati pa 10 VHF wa ntchito ya KFK, chithandizo ndi Atoris ® ziyenera kuyimitsidwa.

Pali malipoti a kakulidwe ka atonic fasciitis ndi kugwiritsa ntchito atorvastatin, komabe, kulumikizana ndi kugwiritsa ntchito mankhwalawa ndizotheka, koma sikunatsimikizidwe, etiology sichikudziwika.

Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala ngati vuto lopanda kufooka kapena kufooka kwa minofu kumachitika, makamaka ngati akuphatikizidwa ndi malaise kapena malungo.

Atoris® imakhala ndi lactose, chifukwa chake kugwiritsidwa ntchito kwa odwala omwe ali ndi kuchepa kwa lactase, kusalolera kwa lactose ndi glucose-galactose malabsorption syndrome ndi kutsutsana.

Kukopa pa kuyendetsa magalimoto ndi kugwira ntchito ndi njira.

Popeza kuthekera kwa chizungulire, kusamala kuyenera kugwiritsidwa ntchito poyendetsa magalimoto ndi zida zina zamaukadaulo zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.

Atoris: malangizo ogwiritsira ntchito, analogi ndi ndemanga

Atorvastatin imachepetsa plasma cholesterol ndi lipoprotein moletsa zoletsa za GMC-CoA, ndipo pambuyo pake, biosynthesis ya cholesterol mu chiwindi, komanso imakulitsa kuchuluka kwa hepatic LDL receptors pamaselo a cell, zomwe zimapangitsa kuti pakhale zambiri zomwe zimachitika komanso LDL catabolism.

Imachepetsa mapangidwe a LDL komanso kuchuluka kwa tinthu ta LDL. Atoris amachititsa kuwonjezereka kosalekeza kwa zochitika za LDL receptors kuphatikiza kusintha kwabwino mumitundu ya LDL yomwe imazungulira.

Mothandizidwa amachepetsa cholesterol ya LDL kwa odwala omwe ali ndi homozygous Famer hypercholesterolemia, ndipo ili ndi gulu lomwe silimayankha nthawi zonse hypolipidemic mankhwala.

M'mawu osavuta, kugwiritsidwa ntchito kwa Atoris kumathandizira kuyimitsa kupanga cholesterol mthupi, kuchepetsa kuchuluka kwa cholesterol otsika kwambiri mu chiwindi.

The achire zotsatira amakula masabata awiri atayamba mankhwalawa, mphamvu kwambiri imatheka pambuyo masabata 4. Asanayambe chithandizo, wodwalayo ayenera kusinthidwa ndi zakudya zomwe zimachepetsa lipid, zomwe ziyenera kuonedwa pakumwa mankhwala.

Atoris imapezeka mu mawonekedwe a piritsi ndi atorvastatin muyeso wa 10, 20 ndi 40 mg piritsi limodzi.

Zizindikiro zogwiritsidwa ntchito

Kodi chimathandiza Atoris ndi chiyani? Lembani mankhwalawa mu milandu iyi:

• zochizira odwala pulayimale (mtundu 2a ndi 2b) ndi hyperlipidemia yosakanikirana.
• makonzedwe a mankhwala akusonyeza odwala homozygous hypercholesterolemia ndi kuchuluka: cholesterol ambiri, otsika kachulukidwe lipoprotein cholesterol, triglyceride kapena apolipoprotein B

Malangizo ogwiritsira ntchito Atoris, mlingo

Mankhwala amatengedwa pakamwa, ngakhale chakudyacho.

Mlingo woyamba wa piritsi la Atoris 10 mg tsiku lililonse. Malinga ndi malangizo, kuchuluka kwa mankhwalawa kumasiyanasiyana kuyambira 10 mg mpaka 80 mg kamodzi patsiku, ndipo amasankhidwa poganizira kuchuluka koyamba kwa LDL-C, cholinga cha mankhwala ndi chithandizo cha munthu. Mlingo weniweni wa mankhwalawa amasankhidwa ndi adotolo, poganizira zotsatira za mayeso ndi kuchuluka koyamba kwa cholesterol.

Kumayambiriro kwa mankhwalawa komanso / kapena pakuwonjezeka kwa mlingo, ndikofunikira kuyang'anira zamasamba a plasma masabata onse a 2-4 ndikusintha mlingo moyenerera.

Mu pulayimale (heterozygous hereditary and polygenic) hypercholesterolemia (mtundu IIa) ndi hyperlipidemia wosakanikirana (mtundu IIb), chithandizo chimayamba ndi mlingo woyambirira, womwe umachulukitsidwa pambuyo pa masabata 4 kutengera momwe wodwalayo amayankhira. Mlingo wapamwamba tsiku lililonse ndi 80 mg.

Kwa okalamba ndi odwala omwe ali ndi vuto laimpso, kusintha kwa mankhwalawa sikofunikira.

Odwala omwe ali ndi vuto la chiwindi, mankhwala amaperekedwa mosamala pokhudzana ndi kutsika kwa mankhwalawa.

Zotsatira zoyipa

Malinga ndi malangizo ogwiritsira ntchito, kuikidwa kwa Atoris kungakhale ndi zotsatirazi:

• Kuchokera ku psyche: kukhumudwa, kusokonezeka kwa kugona, kuphatikizapo kusowa tulo komanso zolakwika.
• Kuchokera ku chitetezo chathupi: thupi lawo siligwirizana, anaphylaxis (kuphatikizapo anaphylactic mantha).
• Matenda a metabolism: hyperglycemia, hypoglycemia, kulemera, anorexia, shuga mellitus.
• Kuchokera pakubala ndi tiziwitsi tambiri: kutomoka, kugona, gynecomastia.
• Kuchokera kwamanjenje: mutu, paresthesia, chizungulire, Hypesthesia, dysgeusia, amnesia, zotumphukira neuropathy.
• Kuchokera kupuma dongosolo: interstitial m'mapapo matenda, zilonda zapakhosi ndi mphuno, nosebleeds.
• Zofooka ndi zofikisa: nasopharyngitis, matenda amkodzo.
• Kuchokera pamagazi ndi dongosolo la lymphatic: thrombocytopenia.
• Kuchokera kumbali ya gawo la masomphenyawo: Kuwona bwino, kuwona kuwonongeka.
• Kuchokera pamtima dongosolo: sitiroko.
• Mbali ya chiwalo chothandizira kumva: tinnitus, kumva kusamva.
• Kuchokera mmimba thirakiti: kudzimbidwa, kugona mosatekeseka, kusanza, kuphwanya m'mimba, kusanza, kupweteka pamimba ndi m'munsi pamimba, kupindika, kapamba.
• Kuchokera ku hepatobiliary system: hepatitis, cholestasis, kulephera kwa chiwindi.
• Pa khungu ndi subcutaneous zimakhala: urticaria, zotupa pakhungu, kuyabwa, alopecia, angioedema, oxerm dermatitis, kuphatikizapo exudative erythema, Stevens-Johnson syndrome, poyizoni epermermal necrolysis, kupindika kwa tendon.
• Kuchokera ku minculoskeletal system: myalgia, arthralgia, kupweteka kwa miyendo, kukokana kwa minofu, kutupa, kupweteka kumbuyo, kupweteka kwa khosi, kufooka kwa minofu, myopathy, myositis, rhabdomyolysis, tendonopathy (nthawi zina kuphatikizidwa ndi kupindika kwa tendon).
• Mavuto wamba: malaise, asthenia, kupweteka pachifuwa, zotupa zakupsa, kutopa, kutentha thupi.

Contraindication

Atoris amatsutsana pamilandu yotsatirayi:

• tsankho limodzi ndi zigawo za mankhwala,
• galactosemia,
• malabsorption wa shuga galactose,
• kufupika kwa lactose,
• matenda a impso,
• mafupa amisempha
• mimba
• yoyamwitsa
• zaka mpaka 10.

Chenjezo liyenera kumwedwa ndi uchidakwa, matenda a chiwindi. Gululi limaphatikizaponso anthu omwe ntchito zawo zimakhala zokhudzana ndi kuyendetsa magalimoto ndi magwiridwe antchito.

Bongo

Pankhani ya bongo, mankhwala othandiza komanso othandizira ayenera kuchitika. Ndikofunikira kuwongolera ntchito ya chiwindi ndi ntchito za CPK mu seramu yamagazi. Hemodialysis siyothandiza. Palibe mankhwala enieni.

Ma analogi a Atoris, mtengo pama pharmacies

Ngati ndi kotheka, Atoris ikhoza kulowa m'malo mwa analogue ya yogwira - awa ndi mankhwala:

Posankha analogi, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito Atoris, mtengo ndi kuwunika kwa mankhwala omwe ali ndi zotsatira zofananira sizikugwira ntchito. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Sungani ku kutentha kosaposa 25 ° C. Moyo wa alumali ndi zaka 2. M'mafakisi, amagulitsidwa ndi mankhwala.

Pali ndemanga zosiyanasiyana za Atoris, monga ambiri amanenera kuti mtengo wokwera wa mankhwalawo umavomerezeka chifukwa chogwira ntchito komanso kulolera bwino.

Dziwani kuti mukamalandira chithandizo, malangizo a dokotala okhudzana ndi kadyedwe komanso zolimbitsa thupi ayenera kutsatiridwa, ndipo posankha ndikusintha mankhwalawa, kugwiritsidwa ntchito kwa lipoprotein kochepa kwambiri kuyenera kukumbukiridwa.

Malinga ndi ogwiritsa ntchito ena, mankhwalawa alibe mphamvu yothandizirana ndipo samatha kulekerera, zomwe zimapangitsa kuti anthu azidzakumana ndi zovuta.

Atoris analogues ndiotsika mtengo

Kuti achepetse kuchuluka kwa lipids m'magazi, madokotala amagwiritsa ntchito mankhwala osiyanasiyana, omwe Atoris ndi analogues ake ndi otchuka kwambiri. Amayesetsa kutsitsa cholesterol yamagazi, potero amasintha thanzi la munthu.

Zokhudza mankhwalawa

Mapiritsi a Atoris amapangidwa ku Slovenia. Mankhwalawa ndi a m'gulu la "ma statins" ndipo amalembedwa kwa odwala kuti achepetse kuchuluka kwa mankhwala ochepetsa mphamvu ya cholesterol) m'thupi.

Atorvastatin ndiye chimake cha mankhwala. Kudutsa m'magazi kulowa m'chiwindi cha chiwindi, atorvastatin imaletsa kapangidwe ka mamolekyulu a cholesterol ndi maselo a chiwindi.

Poyerekeza izi, m'thupi mumayamba kugwiritsa ntchito ma lipoproteins omwe alowa m'magazi, ndikukhala ndi kachulukidwe kakang'ono kwambiri.

Zotsatira zake, luso la Atoris ndi mawonekedwe ake, omwe ali ndi magwiritsidwe ofanana, amakula.

Kuthetsa liphero la atherogenic ndi Atoris sikuti kumapangitsa kuti masinthidwe amitsempha ya makoma amitsempha yamagazi. Nthawi yomweyo, atherosulinosis sikukula ndipo kuwundana kwa magazi sikupanga. Ngati ischemia ikupita patsogolo m'thupi la munthu, kutenga Atoris ndi mawonekedwe ake kumayambitsa kuchepetsa mwayi wokhala ndi stroketi yamtima.

Njira ya Atoris ya muyezo wake ndi mawonekedwe ake amatanthauza kugwiritsa ntchito mankhwala monga adanenera dokotala.

Nthawi zambiri, potengera momwe thupi liliri komanso momwe mtima wake ulili, dokotalayo amawona mlingo woyenera wa mankhwalawa kuti ukhale wathanzi.

Nthawi zambiri, Atoris ndi mawonekedwe ake amafotokozedwa m'magawo otsika, chifukwa izi zimachepetsa mwayi wazotsatira zoyipa.

Atoris analogues yomwe siyotsika mtengo pakukonzekera mankhwalawo payokha akhala akugwiritsidwa ntchito pazachipatala kwazaka zopitilira khumi. Izi zimatsimikiziridwa ndi ndemanga zambiri zabwino za madokotala ndi odwala. Ndi hypercholesterolemia, Atoris ndi mawonekedwe ake amatha kuchepetsa cholesterol pamlingo wovomerezeka kwa kanthawi kochepa, kwinaku akuchepetsa katundu pamtima.

Mpaka pano, ma analogu ambiri a Atoris agwiritsidwa ntchito bwino ndi madokotala kuti achepetse cholesterol yamagazi. Ku Russia, pamashelefu a malo ogulitsa mankhwala, mankhwala omwe amafananizidwa amaperekedwa osati pakupanga kwina, komanso kupangira zapakhomo. Analogue iliyonse ya Atoris imakhala ndi mtundu wake wa kapangidwe kake, zomwe adotolo ayenera kukumbukira asanalembe mankhwala.

Rosuvastatin

Rosuvastatin ndi piritsi la pakamwa lopepuka la pinki kapena la pinki. Monga chofunikira chachikulu ndi mamolekyulu a rosuvastatin, osiyanasiyana pazinthu zosiyanasiyana. Kuphatikiza apo, mapiritsiwo ali ndi:

• stearate magnesium
• ulusi wowuma
• colloidal mawonekedwe a silicon dioxide,
• hypopellose zovuta,
• utoto wapadera
• triacetin
• cellcrystalline mapadi,
• titanium dioxide.

Yogwira ntchito ya mapiritsi omwe afotokozedwawa imadziwika ndi kuponderezana kwa zochitika za ma enzymes amtundu waomwe amapanga mapangidwe a mamolekyulu am'mimba. Mwa izi, cholesterol imapangidwa.

Gulu la mankhwala osokoneza bongo, omwe Rosuvastatin ndi ake, amaletsa mapangidwe a mamolekyulu a mevalonate.

Pambuyo pa kukhazikitsidwa kwa ntchito yake, mankhwalawa amachotsedwa mu mawonekedwe osasinthika kuchokera mthupi limodzi ndi ndowe.

Analogue yotsitsa lipid, yomwe ndi rosuvastatin, imalembedwa kwa odwala omwe ali ndi:

• chachikulu mawonekedwe a hypercholesterolemia,
• hypertriglyceridemia,
• homozygous (banja) chikhalidwe cha hypercholesterolemia.

Mlingo wa yogwira mankhwala akamatenga analog nthawi zonse umaperekedwa ndi dokotala kuti achepetse zovuta zobwera chifukwa cha atherosulinosis. Rosuvastatin nthawi zambiri amawalembera odwala omwe ali ndi zaka zambiri, chifukwa panthawiyi mafuta am'mizere yambiri amakhala ndi mainchesi ang'ono kwambiri, chifukwa amakhala ndi cholesterol.

Mtanda ndi piritsi yozungulira ya pinki yokhala ndi calcium yayikulu rosuvastatin. Ndiye amene amagwira ntchito yofunikira pakumwa mankhwala. The kuchuluka kwa yogwira pophika kutenga Krestor zotchulidwa dokotala, pambuyo yoyenera matenda.

Mankhwalawa ndi othandizira hypercholesterolemia, komanso hypertriglyceridemia.

Komanso mankhwalawa amagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe amadalira shuga. Kuwonongeka kwa mankhwalawa kumachitika m'maselo a chiwindi, ndikutsatira pochotsa m'thupi.

Tengani analogi yoyenera kuti idutse ndi madzi pang'ono. Kuchulukana ndi kuchuluka kwa makonzedwe kumayendetsedwa ndi adokotala pambuyo pofufuza mwapadera dongosolo lamagazi la wodwala. Kudzipatsa wekha Krestor ndi koopsa thanzi, chifukwa kumatha kubweretsa zotsatirapo zake ngati munthu atamwa mankhwala ochuluka.

Cardiomagnyl

Cardiomagnyl ndi imodzi mwazifanizo za Atoris. Zomwe zimagwiritsidwa ntchito ndi mamolekyulu a acetylsalicylic acid okhala ndi magnesium hydroxide. Kuwonjezeka kwa ntchito ya "cholesterol yoyipa" mkati mwa magazi kumatanthawuza kuikidwa kwa Cardiomagnyl ndi adokotala kwa wodwala!

Kumwa mankhwalawa kumalumikizidwa ndi chiwopsezo chowonjezeka cha intravascular thrombosis mthupi. Izi zimachitika:

• mawonekedwe osakhazikika a angina pectoris,
• kuchuluka kwa matenda ashuga,
• kunenepa kwambiri
• matenda oopsa
• myocardial infaration.

Cardiomagnyl amatsutsana mwa anthu odwala:

• chifuwa cha mankhwala,
• matenda am'mimba,
• m'mimba,
• kusowa kwa thupi la K-Vitamini,
• erosive and ulcerative pathologies mkati mwa ziwalo zogaya,
• kwambiri madigiri kulephera kwa aimpso.

Cardiomagnyl saloledwa kuti atengedwe ndi anthu omwe akuvutika kuti asalole thupi la acetylsalicylic acid mamolekyulu okhala ndi magnesium hydroxide, komanso pa nthawi yoyembekezera.

Simvastatin

Atoris kapena simvastatin yothandiza kwambiri? Simvastatin ndi mankhwala osokoneza bongo a hypolipidemic okhala ndi kuchuluka kwa zinthu zomwe zili ndi dzina lomweli. Mankhwalawa amaperekedwa kwa odwala omwe ali ndi vuto lalikulu la mankhwala okhala ndi lipid m'magazi.

Zotsatira zake, palibe kuchuluka kwa poizoni wophatikizira m'thupi. Pogwira ntchito kwambiri mankhwalawa, mankhwalawo ali ndi mtengo wovomerezeka, womwe umapangitsa kuti azitchuka pakati pa anthu. Kukula kwa myopathy yaumunthu ndi chizindikiro chosiya kumwa mankhwalawa.

Atoris kapena Atorvastatin: ndibwino bwanji? Musanasankhe analogue ya Atoris, muyenera kufunsa dokotala yemwe, atayeza thupi mwatsatanetsatane, athe kupereka mankhwala otetezeka komanso othandiza kwa wodwala.

Timalimbikitsa! Pochizira komanso kupewa matenda a ZINSINSI NDI ZOTHANDIZA, owerenga athu amagwiritsa ntchito njira yofulumira komanso yopanda opaleshoni yolimbikitsidwa ndi akatswiri opanga ma rheumatologists ku Russia, omwe adaganiza zotsutsa kusayeruzika kwa zamankhwala ndikupereka mankhwala omwe ALIYENSE OONSE! Tidadziwana ndi njirayi ndipo tinaganiza zopereka chidwi chanu.

Atoris: malangizo ogwiritsira ntchito, analogi, mtengo, ndemanga

Atoris ndi amodzi mwa mayina amalonda a atorvastatin opangidwa ndi kampani yaku Slovenia Krka. Mwa zina zamagetsi, mankhwalawa amapezeka mosiyanasiyana kwambiri.

Atoris adalembedwa kuti achepetse cholesterol, "zovulaza" lipoproteins, triglycerides, komanso kuwonjezera kuchuluka kwa "lipoproteins zabwino.

Malangizowo akuwonetsa kuti anthu omwe akumwa mankhwalawo Atoris ndi anthu omwe ali ndi vuto la hypercholesterolemia, matenda a mtima (CHD), komanso matenda a shuga.

Kuphatikizika, mawonekedwe omasulidwa

Atoris ndi piritsi lomwe lili ndi 10, 20, 30, 60, kapena 80 mamiligalamu a zinthu zomwe zimagwira. Kuzungulira, mawonekedwe, oyera. Pamlandu - wandiweyani, woyera.

Zomwe zimagwira mu Atoris ndi calcium wa atorvastatin. Kuphatikiza apo, mapangidwe a mankhwalawa amaphatikizapo: povidone, sodium lauryl sulfate, calcium carbonate, cellulose, lactose monohydrate, croscarmellose, magnesium stearate. Piritsi iliyonse imakhala yokutidwa ndi Opadry 2.

Atoris: Zizindikiro zogwiritsidwa ntchito

Asanayambe kumwa mankhwalawa, wodwalayo amamugulitsa ku chakudya chomwe chimachepetsa kuchuluka kwa mafuta m'thupi, LDL. Iyenera kuonedwa munthawi yonse ya chithandizo. Kunyalanyaza zakudya kumachepetsa kapena kumapangitsa mphamvu ya atorvastatin mankhwala.

Malinga ndi malangizo, mapiritsi a Atoris amagwiritsidwa ntchito pochiza:

• homo-, heterozygous achibale komanso osakhala aubanja hypercholesterolemia,
• kuphatikiza matenda ophatikizira,
• dysbetalipoproteinemia,
• m'mabanja hypertriglyceridemia.

Atoris amathandizanso kupewa matenda a mtima. Chifukwa cha anti-atherogenic katundu wa mankhwala:

• amachepetsa kufa kwa matenda a mtima,
• Imachepetsa mwayi wokhala ndi vuto la mtima, kugunda,
• imaletsa kuukira kwa angina,
• amachepetsa chiwerengero cha odwala omwe akufunika opaleshoni.

Njira ya ntchito, Mlingo

Mapiritsi a Atoris amatengedwa kamodzi / tsiku asanagone, isanachitike, itatha kapena itatha kudya. Ndikofunika kumwa mankhwalawa nthawi yomweyo.

Chifukwa chiyani ndikofunikira kutenga Atoris madzulo? Usiku, chiwindi chimapanga cholesterol yambiri. Ngati mukuyiwala kumwa mapiritsi, atenge msanga.

Dumulani nthawi imodzi ngati maola ochepera 12 atsala mpaka lotsatira. Poterepa, mlingo wa mankhwalawa suyenera kuchuluka.

Mlingo woyenera wa mankhwalawa ndi 10-80 mg. Mukamasankha mlingo wa Atoris, kuchuluka koyamba kwa cholesterol, LDL, kupezeka kwa zovuta zamtundu umodzi, kugwiritsa ntchito mankhwala ena kumawaganiziridwa.

Chithandizo chimayamba ndi mlingo wochepa wa mankhwalawa (10-20 mg). Pambuyo pa milungu inayi, dokotala amawunikira kusintha kwakusintha kwa cholesterol, lipoproteins. Ngati kufunika komwe sikukwaniritsidwa, mlingo wa Atoris ukuwonjezeka. Ndi cholesterol yotsika, mapiritsi omwe amakhala ndi chidwi chogwira ntchito amapatsidwa.

Kuwongolera cholesterol, odwala omwe amatenga erythromycin, clarithromycin, lopinavir, ritonavir, Atoris ndi mankhwala osaposa 20 mg.

Munthawi yonse ya chithandizo, ndikofunikira kuwongolera kuchuluka kwa cholesterol, LDL, VLDL, triglycerides, chiwindi, zitsanzo za impso, CC. Izi zimathandizira kuwunika momwe thupi limayankhira kugwiritsidwa ntchito kwa Atoris, ndikuwonetsanso kukulira kwa zovuta pakapita nthawi.

Kuchita

Kugwiritsa ntchito pamodzi kwa mapiritsi a Atoris omwe ali ndi mankhwala ena kumakhala ndi zotsatirapo zoipa kapena kuchepa kwa mphamvu ya imodzi mwazo.

Mankhwalawa sanatchulidwe kwa anthu omwe amamwa:

• mankhwala antifungal a gulu la azole,
• maantibayotiki ena (cyclosporine, telithromycin),
• gemfibrozil
• Ma protein a HIV (ritonavir, lopinavir),
• fusidic acid
• kumwa madzi a mphesa.

Mankhwala ena, akamwedwa pamodzi ndi Atoris, amafunikira kusintha kwa mlingo. Mndandanda wawo uli mgawo "Njira yogwiritsira ntchito ndi Mlingo."