Mtengo ndi kusiyana kwa kapangidwe ka "Humalog", malangizo ogwiritsira ntchito, ndemanga ndi fanizo la insulin

Kuti mupeze chipukutiro cha matenda a shuga kwa nthawi yayitali, mitundu yambiri ya insulin imagwiritsidwa ntchito. Insulin Lizpro ndi mankhwala amakono kwambiri komanso otetezeka omwe amagwiritsa ntchito kagayidwe kazakumwa.

Chida ichi chikhoza kuwonetsedwa kuti chitha kugwiritsidwa ntchito ndi odwala matenda ashuga a mibadwo yosiyanasiyana. Insulin Lizpro imatha kuperekedwa kwa ana omwe ali ndi matenda ashuga.

Poyerekeza ndi ma insulin osagwira ntchito mwachidule, Insulin Lizpro imagwira ntchito mwachangu, chifukwa cha kuyamwa kwambiri.

Pharmacological zochita ndi zikuwonetsa

Lizpro biphasic insulin idapangidwa pogwiritsa ntchito ukadaulo wa DNA. Pali mgwirizano ndi cholandilira cha cytoplasmic membrane wa maselo, insulin-receptor tata imapangidwa, yomwe imapangitsa njira mkati mwa maselo, kuphatikizapo kaphatikizidwe ka michere yofunika.

Kuchepa kwa kuchuluka kwa shuga m'magazi kumafotokozedwa ndikuwonjezereka kwa kayendedwe kake ka intracellular, komanso kuwonjezeka kwa mayamwidwe ndi kuperewera kwa maselo. Shuga amatha kuchepa chifukwa chakuchepa kwa kuchuluka kwa kapangidwe kake ka chiwindi kapena kukondoweza kwa glycogenogeneis ndi lipogenesis.

Lyspro insulin ndi mankhwala obwerezabwereza a DNA omwe amasiyana m'njira zotsalira za lysine ndi proline amino acid m'malo a 28 ndi 29 a insulin B. Mankhwalawa ali ndi 75% protamine kuyimitsidwa ndi 25% lyspro insulin.

Mankhwalawa ali ndi zotsatira za anabolic komanso malamulo a shuga. Mu minofu (kupatula minofu ya muubongo), kusintha kwa glucose ndi ma amino acid mu cell kumathandizira, zomwe zimapangitsa kuti glycogen ipangidwe ndi shuga mu chiwindi.

Mankhwalawa amasiyana ndi ma insulin ochiritsira omwe amapezeka mwachangu pakuthamanga kwa thupi ndi zotsatira zoyipa zochepa.

Mankhwalawa amayamba kuchita pambuyo pa mphindi 15, chifukwa cha kuyamwa kwambiri. Chifukwa chake, chitha kuperekedwa kwa mphindi 10-15 chakudya chisanafike. Insulin yokhazikika imayendetsedwa osakwana theka la ola.

Kuchuluka kwa mayamwidwe kumakhudzidwa ndi tsamba la jakisoni ndi zina. Pachimake pazochitikazo zimawonedwa mu maola 0,5 - 2,5. Insulin Lizpro amachita kwa maola anayi.

Lizpro insulin mmalo amasonyezedwa kwa anthu odwala mtundu 1 shuga, makamaka vuto la insulin. Kuphatikiza apo, imagwiritsidwa ntchito pazinthu zotere:

• postprandial hyperglycemia,
• subcutaneous insulin kukana mu pachimake mawonekedwe.

Mankhwalawa amagwiritsidwanso ntchito ngati mtundu wachiwiri wa matenda osokoneza bongo omwe amatsutsana ndi hypoglycemic.

Lizpro insulin imatha kupatsidwa mankhwala omwe amalumikizana nawo.

Insulin Apidra Solostar: malangizo ogwiritsira ntchito yankho

Apidra Solostar ndi insulin yochepa, yomwe cholinga chake ndi kuwongolera glycemic m'njira yodalira matenda a shuga.

Amalembera achikulire ndi ana azaka zopitilira 6 omwe akudwala matenda ashuga, ngati kuli kotheka, mankhwala a insulin.

Kupanga ndi mafomu omasulira

Mu 1 millilita ya Apidra Solostar yankho lili ndi chokhacho chophatikizira - insulin glulisin mu gawo la 100 PIECES. Komanso, mankhwalawa ali ndi:

• Hydroskide ndi Sodium Chloride
• Madzi okonzedwa
• Metacresol
• Polysobat
• Trometamol
• Hydrochloric acid.

Njira yokhala ndi insulini ndi madzi osavuta, osasankhidwa, omwe amapezeka mumbale 3 ml. Paketiyi imaphatikizapo mabotolo amodzi kapena asanu okhala ndi zolembera.

Kuchiritsa katundu

Insulin glulisin yomwe ili mu Apidra ndi njira yofananira ndi ya insulin yomwe imapangidwa m'thupi la munthu. Glulisin amachita zinthu mwachangu kwambiri ndipo amadziwika ndi nthawi yochepa poyerekeza ndi insulin yachilengedwe.

Mothandizidwa ndi insulin glulisin, kusintha pang'onopang'ono kwa kagayidwe ka glucose kumawonedwa. Ndi kuchepa kwa shuga, kukondoweza kwa mayamwidwe ake mwachindunji ndi zotumphukira, kuphatikizira kwa kaphatikizidwe ka glucose m'maselo a chiwindi amalembedwa.

Insulin imalepheretsa njira ya lipolysis yomwe imachitika mu adipocytes, komanso proteinolysis. Nthawi yomweyo, kaphatikizidwe wamaproteni amakula kwambiri.

Chifukwa cha kafukufuku wambiri ndi kutenga nawo mbali anthu omwe ali ndi matenda ashuga, komanso odwala athanzi, zotsatira zotsatirazi zidapezeka: ndi subcutaneous makonzedwe a Apidra, kuchitapo kanthu mofulumira kwa insulin kumawonedwa ndi kufupika kwakanthawi kuposa insulin yamadzimadzi yotentha.

Pambuyo pa kukhazikitsidwa kwa glulisin pansi pa khungu, zotsatira zake zimadziwika pambuyo pa mphindi 10-20. Koma pakubayidwa m'mitsempha, ndolo ya glucose imatsika chimodzimodzi ngati pambuyo pobweretsa insulin yachilengedwe. 1 unit ya insulin glulisin imadziwika ndi katundu wofanana ndi glucose wofanana ndi gawo limodzi la insulin yachilengedwe.

Odwala omwe ali ndi matenda a aimpso, kufunika kwa insulin nthawi zambiri kumachepetsedwa.

Apidra Solostar: malangizo ogwiritsira ntchito

Subcutaneous makonzedwe a Apidra ayenera kuchitika musanadye kapena pambuyo chakudya.

Mankhwala okhala ndi insulin ayenera kugwiritsidwa ntchito molingana ndi dongosolo la mankhwala antidiabetesic limodzi ndi insulin, yomwe imadziwika ndi kutalika kwakanthawi kapena insulin. Mwina mungagwiritse ntchito mankhwala ophatikizira a hypoglycemic pakamwa.

Kusankhidwa kwa regimen ya muyezo kumachitika ndi endocrinologist.

Mafala Akutoma

Kukhazikitsidwa kwa yankho la insulini kumachitika mosadukiza ndi jakisoni kapena kulowetsedwa pogwiritsa ntchito pulogalamu yapadera ya pampu.

Subcutaneous jakisoni imachitika m'mimba khoma (mwachindunji mbali yake yakumbuyo), m'chigawo chachikazi kapena phewa. Kulowetsedwa kwa mankhwala ikuchitika m'mimba khoma. Malo omwe kulowetsedwa ndi jekeseni ayenera kukhala akusintha mosalekeza.

Momwe mungagwiritsire ntchito cholembera

Apidra isanayambike, cholembera chimakhala chofunikira kuti chiwotche kutentha pang'ono (pafupifupi maola 1-2).

Singano yatsopano imalumikizana ndi cholembera cha insulin, ndiye kuti muyenera kuyesa mayeso otetezeka. Pambuyo pake, chizindikirocho "0" chidzawoneka pazenera la drr. Kenako mulingo woyenera umakhazikitsidwa. Mtengo wocheperako wa mlingo womwe waperekedwa ndi gawo limodzi, ndipo pazofunikira ndi magawo 80. Ngati pakufunika bongo wambiri, jakisoni zingapo zimaperekedwa.

Nthawi ya jakisoni, singano, yomwe imayikidwapo cholembera, imayenera kuyikiridwa pang'onopang'ono pakhungu. Batani pa syringe cholembera lidzakanikizidwa, liyenera kukhalabe pomwepo mpaka mphindi yakucha. Izi zimathandizira kuyambitsidwa kwa mlingo woyenera wa mankhwala okhala ndi insulin.

Pambuyo jakisoni, singano imachotsedwa ndikuitaya. Chifukwa chake, zitha kuteteza matenda a insulin. M'tsogolomo, cholembera cha syringe iyenera kutsekedwa ndi chipewa.

Mankhwala atha kuperekedwa kwa amayi apakati komanso akakhanda.

Contraindication ndi Kusamala

Mtengo: kuchokera 421 mpaka 2532 rub.

Mankhwala okhala ndi insulin Apidra Solostar sagwiritsidwa ntchito kuwonetsa hypoglycemia ndikuwonjezereka kwa magawo a mankhwala.

Mukamagwiritsa ntchito mankhwala ena a insulin ochokera kwa wopanga wina, muyenera kuwongolera chithandizo chamankhwala a antiidiabetic ndi dokotala, chifukwa kufunika kosintha kwakumwa kwa mankhwalawo sikungadziwike. Mungafunike kusintha chiwembu cha hypoglycemic mankhwalawa pakamwa.

Kutsiliza kwa mankhwala othandizira kapena kugwiritsa ntchito mankhwala osokoneza bongo okwanira, makamaka mwa anthu omwe ali ndi matenda ashuga, kumatha kuyambitsa matenda a shuga komanso matenda a hypoglycemia.

Nthawi yopezeka ya hypoglycemia ikukhudzana mwachindunji ndi kuchuluka kwa chitukuko cha hypoglycemic kuchokera ku mankhwala omwe amagwiritsidwa ntchito, amatha kusintha ndi kusintha kwa chithandizo cha antidiabetesic.

Zina zomwe zimatha kuchepetsa zovuta za hypoglycemia, zimaphatikizapo:

• Njira yayitali ya matenda a shuga
• Kwambiri insulin mankhwala
• Kukula kwa matenda a shuga
• Kugwiritsa ntchito mankhwala angapo (mwachitsanzo, β-blockers).

Kusintha kwa mlingo wa insulin Apidra Solostar kumachitika ndikuwonjezera kwa zolimbitsa thupi kapena kusintha kwa zakudya za tsiku ndi tsiku.

Pankhani ya kuchuluka zolimbitsa thupi mutatha kudya, mwayi wokhala ndi hypoglycemia ukuwonjezeka. Kuchita insulin mwachangu kungayambitse hypoglycemia.

Zizindikiro zosasinthika za hypo- ndi hypoglycemic zimayambitsa kupezeka kwa matenda a shuga, chikomokere, kapena kutsogolo kwa imfa.

Ndi kusintha kwa mkhalidwe wamalingaliro, kukula kwa matenda ena, pangafunikire kusintha mlingo wa mankhwala okhala ndi insulin.

Mukamagwira ntchito mosamala, magalimoto oyendetsa, chiopsezo chokhala ndi hypo- ndi hyperglycemia chikuwonjezeka, choncho muyenera kusamalidwa mwapadera.

Kuchita mankhwala osokoneza bongo

Mukamamwa mankhwala ena, zimachitika kuti kagayidwe kazakudwala kajambulidwe, mogwirizana ndi izi, pakufunika kusintha Mlingo wa glulisin ndikuwongolera machitidwe a antidiabetesic mankhwala.

Mwa zina mwa mankhwala omwe amalimbikitsa kuchuluka kwa hypoglycemic a glulisin ndi:

• Zoletsa zina za angiotensin zotembenuza enzyme, monoamine oxidase
• Pentoxifylline
• Mankhwala othandizira
• Njira zochokera sulfonamide antimicrobial agents
• Disopyramides
• Hypoglycemic mankhwala opangira pakamwa
• Fluoxetine
• Salicylates
• Propoxyphene.

Mankhwala angapo amaperekedwa omwe amachepetsa kwambiri hypoglycemic zotsatira za yankho la insulin:

• Isoniazid
• Somatropin
• Danazole
• Ena achifundo
• Mankhwala a estrogen-progestin
• COC
• Diazoxide
• Mapuloteni oletsa
• Mahomoni a chithokomiro
• Mankhwala a antipsychotic
• GKS
• Phenothiazine Derivatives
• Mankhwala osokoneza bongo.

Ndizofunikira kudziwa kuti β-adrenergic blockers, mankhwala okhala ndi ethanol komanso ma lithiamu, clonidine amatha kuwonjezera ndikuchepetsa mphamvu ya hypoglycemic ya Apidra.

Pogwiritsa ntchito reserpine, β-adrenoblockers, clonidine, ndi guanethidine, zizindikiro za hypoglycemia zitha kukhala zopanda mphamvu kapena zosakhalapo.

Popeza palibe chidziwitso pakudziwika kwa mankhwala a gluzilin, osasakanikirana ndi mankhwala ena, insulin isofan ndiyosiyana.

Pankhani yogwiritsa ntchito pampu kulowetsedwa kupatsa Apidra, kusakaniza njira yokhala ndi insulin ndi mankhwala ena sikuyenera kutero.

Zotsatira zoyipa ndi bongo

Nthawi zambiri, anthu odwala matenda ashuga amatha kukhala ndi vuto ngati hypoglycemia.

Nthawi zina, totupa pakhungu ndi maonekedwe a kutupa kwanuko kumawonedwa.

Kupezeka kwa lipodystrophy ngati sikutsatira dongosolo lodziwika bwino la chithandizo chamankhwala sikulakwa.

Mawonetseredwe ena omwe amatsutsa ndi monga:

• Matenda a khungu lawo siligwirizana, mwachangu ndi mtundu wa uritisaria, kupindika
• Kumverera kwamphamvu m'chifuwa (m'malo osowa).

Ndikofunika kudziwa kuti zomwe zimachitika pakhungu lathupi lathu (chiwonetsero cha thupi lawo) zimathandizidwenso tsiku lotsatira jekeseni. Nthawi zina, zizindikiro zoyipa sizobwera chifukwa cha kuwonekera kwa insulin, koma chifukwa cha mkwiyo pakhungu chifukwa cha chithandizo chamankhwala chisanayambidwe ndi jakisoni kapena chifukwa cha jakisoni wosayenera.

Mukazindikira matenda amtundu wonse, chiopsezo cha kufa chimakhala chachikulu. Chifukwa chake, pakuwonetsedwa pang'ono kwa zovuta zammbali, muyenera kufunsa dokotala.

Ndi kukhazikitsidwa kwa mankhwala ochulukirapo a Apidra, hypoglycemia ikhoza kukhala yofatsa komanso yowopsa. Pankhaniyi, ndikofunikira kuchitira chithandizo:

• Ofatsa - Zakudya zokhala ndi shuga kapena zakumwa
• Mawonekedwe owopsa (osazindikira chikumbumtima) - pakuyimitsidwa, 1 ml ya mankhwala Glucagon amaperekedwa pansi pa khungu kapena minofu, osagwirizana ndi Glucagon, njira yolowerera shuga ndiyotheka.

Wodwala akayambanso kuzindikiridwa, zidzakhala zofunikira kumamupatsa chakudya chamafuta ambiri. Pambuyo pake, kuwunika momwe wodwalayo alili ndi dokotala wololedwa kumalimbikitsidwa.

Eli Lilly ndi Company, France

Mtengo kuyambira 1602 mpaka 2195 rub.

Humalogue ndi amodzi mwa othandizira omwe amawonetsa zotsatira za hypoglycemic. Humalog ili ndi insulin lyspro. Mothandizidwa ndi mankhwalawa, ndizotheka kuyendetsa kagayidwe kazakudya ndikuwonjezera kwambiri mapuloteni. Mankhwala amapangidwa mwanjira yankho ndi kuyimitsidwa.

Ubwino:

• Kugwiritsa ntchito
• Kukhazikika kwa hypoglycemic kwambiri
• Zovuta zoyipa ndizokayikitsa.

Chuma:

• Musagwiritse ntchito ngati hypoglycemia ikukayikiridwa.
• Mtengo wokwera
• Zingayambitse thukuta.

Humulin NPH

Eli Lilly East S.A., Switzerland

Mtengo kuyambira 148 mpaka 1305 rub.

Humulin NPH - mankhwala omwe ali ndi yogwira insulin-isophan, amagwiritsidwa ntchito mu shuga kuwongoletsa glycemia. Humulin NPH imapangidwa mwa njira yothetsera mavitamini omwe amagwiritsidwa ntchito cholembera.

Ubwino:

• Atha kulembetsa kukhala ndi pakati
• Gwiritsani ntchito matenda oyamba a shuga
• Mankhwala a antidiabetic a nthawi yayitali amaloledwa.

Chuma:

• Zingayambitse kuyabwa kwadzaoneni.
• Pazotsatira zamankhwala, kugunda kwa mtima kumatha kupezeka
• Amangotulutsidwa ndi mankhwala okha.

Novo Nordic, Denmark

Mtengo kuchokera 344 mpaka 1116 rubles.

LS ili ndi insulin yochepa. Amalandira mankhwala a shuga osagwirizana ndi glycemic control ndi mankhwala ena. Mothandizidwa ndi Actrapid, njira ya intracellular njira imayendetsedwa chifukwa cha kusunthidwa kwacamP biosynthesis komanso kulowa mwachangu m'maselo a minofu. The yogwira thunthu ndi sungunuka insulin. Mankhwala amapangidwa mwanjira yothetsera.

Ubwino:

• Mtengo wotsika
• Kuchepetsa msanga kwa shuga m'magazi
• Itha kugwiritsidwa ntchito ndi insulin yayitali.

Chuma:

• Maonekedwe a zizindikiro za lipodystrophy samatsutsidwa
• Quincke edema imayamba
• Ndi zochulukirapo zolimbitsa thupi, kusintha kwa mlingo kumafunika.

Kugwiritsa ntchito insulin Humalog Lizpro

Lizpro insulin ndi mawonekedwe a insulin ya anthu. Chochita chachikulu cha chida ichi ndi kuyang'anira kupanga shuga ndi kukonza. Nthawi yomweyo, ndi Lizpro insulin yomwe imadziwika ndi katundu wa anabolic, ndiye kuti, imathandizira kwambiri kukula kwa minofu.

Poyerekeza ndi kafupikitsidwe ka insulin, akatswiri a insulin Lizpro (Humalog) amawona kuyambika ndi kutsiriza kwa zomwe zimachitika.

Ndikulimbikitsidwa kuti muthe chidwi pazomwe zimatulutsidwa, kugwiritsa ntchito chida ichi - zonsezi zithandiza kuti odwala matenda ashuga azigwiritsa ntchito molondola.

Mawonekedwe ndi mawonekedwe a mankhwalawa

Insulin Lizpro ndi yotsalira komanso yankho lomveka bwino, lomwe limapangidwira kuti lizitha kuyambitsa ziwopsezo zonse komanso zamkati. Tiyenera kukumbukira kuti Humalog imaphatikizapo insulin yayikulu yogwira Lizpro mu 100 IU. Kuphatikiza apo, tisaiwale za zina zothandizira, makamaka:

• glycerol (glycerin),
• zinc oxide
• metacresol
• sodium hydrogen phosphate heptahydrate,
• 10% hydrochloric acid solution ndi / kapena 10% sodium hydroxide solution,
• madzi.

Chisamaliro chapadera chimayenera kuyikidwa kwa insulin Lizpro (Humalog). Tikulankhula za ma cartridge atatu atatu-ml m'matumba kapena ma cartridge atatu atatu-ml atatu odziwitsa syringe. Kuti mumvetsetse bwino momwe algorithm amakhudzira mphamvu ya chinthu chamafuta, limalimbikitsidwa kuti lizilingalira kwambiri za mfundo zake zamankhwala.

Zomwe muyenera kudziwa pokhudzana ndi zamankhwala?

Lizpro imatha kukhala ndi vuto lalikulu pakuwongolera kwa shuga. Kuphatikiza apo, gawo la mahomoni limadziwika ndi ena mwa ma anabolic parameter. Amadziwika ndi kuthekera kwakwe kothamangitsa kusintha kwa glucose ndi amino acid kukhala ma cell.

Kuphatikiza apo, ndi gawo ili la mahomoni lomwe limathandiza kwambiri kupanga glycogen kuchokera ku glucose m'chiwindi. Zimathandizanso kupondereza gluconeogeneis ndikuthandizira kusintha kwa glucose owonjezera kukhala mafuta.

Insulin iyi ndiyofanana ndi insulin yaumunthu (imakhala ndi mular boima).

Akatswiri amawunikira kuti kuyambiranso kumachitika mwachangu kuposa mitundu ina ya insulini.

Kuphatikiza apo, kupangidwako kumadziwika ndi chitukuko chakumapeto kwa chiwonetsero komanso nthawi yochepa yomwe ikufunika pa zochitika za hypoglycemic. Kuyambika mwachangu (mphindi 15 pambuyo pa kubayidwa) kumalumikizidwa ndi kuyamwa mwachangu.

Ndi izi, chifukwa, zimapangitsa kuti zizidziwike nthawi yomweyo musanadye chakudya. Ngakhale insulin yaumunthu yovomerezeka imalimbikitsidwa kuti isagwiritsidwe ntchito mopitilira mphindi 30 asanadye.

Madera omwe jakisoni imakhala nayo mwachindunji pamlingo wa mayamwidwe, komanso poyambira chiyambi chake. Ichi ndichifukwa chake muyenera kufikira mosamalitsa machitidwe otere ndikufunsira katswiri.

Mwa zina, musanayambe kugwiritsa ntchito insulin, Lizpro adzadziwa bwino zomwe zikugwiritsidwe ntchito.

Malamulo ogwiritsira ntchito insulin Tresiba

Zizindikiro zazikulu zogwiritsidwa ntchito

Polankhula za zazikulu zomwe zikugwiritsidwa ntchito, ndikofunikira zonse kuti muzisamala kwambiri za mtundu wa matenda ashuga 1. Komanso, izi ndizofunikira pokhudzana ndi tsankho la mitundu ina ya mahomoni. Chizindikiro chotsatira ndi mtundu wa hypprlycemia wa postprandial womwe sungathe kuwongoleredwa ndi mitundu ina ya insulin.

Chizindikiro china chotsimikizika chiyenera kuonedwa ngati mtundu wachiwiri wa matenda a shuga, kutanthauza kuti ngati sizingatheke kugwiritsa ntchito mankhwala aliwonse otsitsa shuga.

Komanso, munthu sayenera kuyiwala kuti Lizpro insulin ndi yovomerezeka pamene mitundu ina ya insulini singamwe.

Ndipo, chomaliza, chizindikiritso china ndi kugwiranso ntchito kwa odwala matenda ashuga.

Mlingo ndi makonzedwe

Mulingo wofanana wa Lizpro insulin wolowetsedwa bwino amalimbikitsidwa kutengera kuchuluka kwa glycemic. Ponena izi, ndikulimbikitsidwa kuti mutchere chidwi kuti:

• ngati ndi kotheka, imagwirira ntchito limodzi ndi mahomoni ena amtundu wautali wowonekera kapena ndi pakamwa ndi sulfonylurea mwa iwo.
• jakisoni amachitika kokha pansi pa khungu m'mapewa, m'chiuno, komanso mu peritoneum ndi matako,
• tsamba lenileni la jekeseni liyenera kusinthidwa kuti musagwiritse ntchito kamodzi pamwezi,
• Ndikulimbikitsidwa kwambiri kuti musamale ndi mitsempha yamagazi yomwe imatalikirana kwambiri.

Odwala omwe ali ndi vuto la impso kapena hepatic amatha kukhala ndi kuchuluka kwa kuzungulira kwa insulin, koma ndi kuchepetsedwa kwake.

Zonsezi zifunikira kuwunika kwamuyaya kwa chiŵerengero cha glycemia, komanso kukonza munthawi yake kuchuluka kwa gawo la mahomoni.

Kukumbukira zovuta zomwe zimagwiritsidwa ntchito komanso kumwa, munthu sayenera kuyiwala za contraindication ndi zovuta zina, zomwe ndizofunikira kwambiri kwa aliyense wodwala matenda ashuga.

Contraindication ndi zoyipa

Otsogolera contraindication ayenera kumwedwa payekha tsankho, kupezeka insulinomas mwa anthu, komanso hypoglycemia.

Komabe, izi sizili kutali ndi onse, chifukwa ndikofunikira kukumbukira kufunika kwa zovuta zina. Polankhula za izi, iwo amatchera khutu ku mawonetsedwe ena olimbana nawo. Izi zimaphatikizira urticaria, kukula kwa angioedema, komwe kumayendetsedwa ndi kutentha thupi, kufupika, kuchepa kwa magazi.

Zotsatira zina zosafunikira kwenikweni ndizovuta kwakanthawi kochepa, kukula kwa hypoglycemia kapena hypoglycemic coma, komanso kuphatikiza kwa lipodystrophy. Muzochitika zambiri, izi zitha kupewedwa ngati malingaliro onse a katswiri atsatiridwa, komanso kukumbukira momwe gawo la mahomoni liyenera kugwiritsidwira ntchito.

Kodi mankhwala osokoneza bongo ochuluka bwanji?

Mankhwala osokoneza bongo a insulin Lizpro (Humalog) awonetsa mawonetseredwe. Choyamba, tikulankhula za thukuta, thukuta lalikulu, tachycardia ndi kunjenjemera. Tisaiwale kuti kuwoneka ngati kumverera kwa njala, nkhawa ndizotheka.

Nthawi zina, munthu amakhala ndi mavuto okhudzana ndi ntchito zooneka ndi zina.

Popeza kuopsa kwa vutoli, ndikulimbikitsidwa kuti musamale ndi momwe mungathane ndi zovuta za matenda osokoneza bongo.

Chifukwa chake, polankhula zamankhwala, ziyenera kukumbukiridwa kuti wodwalayo akakhala kuti ali ndi vuto, adzafunika jakisoni wa Dextrose. Pangakhalenso kufunikira kwamkati popanga glucagon kapena hypertonic dextrose.

Kupangidwe kwa chikomokere kwa hypoglycemic mwa wodwala kumatanthauza kugwiritsa ntchito njira yolimba ya jet ya Dextrose. Izi zikufunika kuchitika wodwala asanachoke.

Kuti mumvetsetse bwino momwe mankhwalawa amagwiritsidwira ntchito, ndikofunikira kuganizira momwe zimagwirizanirana ndi mitundu ina ya mahomoni ndi mankhwala.

Kugwirizana ndi njira zina

Pozindikira mawonekedwe ndi zizindikiro zonse zakugwirizana ndi zida zina, akatswiri amalimbikitsa mwamphamvu kuyang'anira chidwi monga izi:

• kusakwanira koyenera ndi mankhwala ena
• hypoglycemic algorithm yowonetsera insulin idzakulitsidwa kwambiri ndi sulfonamides, Mao inhibitors, a carbonrasehydrate. Ketoconazole, clofibrate ndi mankhwala ena ambiri atha kukhala ndi zotsatira zofananira.
• mankhwala monga glucagon, njira zakulera zamkati, estrogens, nikotini ndi zina zomwe zimapangitsa kufooka kwa hypoglycemic algorithm. Ichi ndichifukwa chake ndikofunikira kwambiri kufunsa katswiri musanakumane.
• Hypoglycemic zotsatira za gawo la mahomoni zimatha kufooketsa kapena kulimbitsa zinthu monga beta-blockers, reserpine, Pentamidine ngakhale Octreotide.

Komanso, ndikufuna kudziwa malangizo ena apadera omwe amalimbikitsidwa kuti muziganizira musanayambe kugwiritsa ntchito Lizpro insulin (Humalog).

Kodi ndi malangizo ati omwe angayambitsidwe?

Kutsatira kwambiri kukhazikitsidwa kwa algorithm ndikofunikira. Mukasamutsa odwala matenda ashuga ku insulin Lizpro yokhala ndi mahomoni okhala ndi mawonekedwe amtundu wodziwikiratu, kusintha kwakukulu kungakhale kotheka.

Ngati mlingo womwe umadutsa maola 24 kwa wodwalayo unali woposa magawo zana, ndiye kuti kusamutsidwa kuchokera ku mtundu wina wa insulin kupita ku wina kumachitika mu chipatala.

Kufunika kwa insulin yowonjezereka kumawonjezera ndi mitundu yambiri ya matenda opatsirana, kupsinjika kwamalingaliro, kuwonjezeka kwa chiwopsezo cha chakudya chamagulu m'zakudya ndi zochitika zina zomwe muyenera kufunsa dokotala.

Kufunika kwa gawo la mahomoni kumachepa ndi kuchepa kwa magazi aimpso kapena kwa chiwindi, kuchepa kwa kuchuluka kwa chakudya chamagulu m'zakudya ndikuwonetsa zizindikiro zolimbitsa thupi. Kuchekera kwa mapangidwe a hypoglycemia kumakulitsa kuthekera kwa odwala matenda ashuga ambiri kuyendetsa galimoto komanso kusamalira machitidwe osiyanasiyana.

Ndizofunikira kudziwa kuti odwala matenda ashuga amatha kuyimitsa pang'ono hypoglycemia chifukwa cha zoyesayesa zawo, ngati amamwa shuga wambiri kapena kugwiritsa ntchito chakudya chomwe chili ndi chakudya chambiri. Ndikulimbikitsidwa kwambiri kudziwitsa katswiri yemwe wakhudzidwa ndi matenda omwe asinthidwa a hypoglycemia, omwe akuwonetsa momwe mlingo wake ungasinthidwe.

Insulin Lantus: malangizo, mtengo, ndemanga za anthu odwala matenda ashuga

Lantus ndi imodzi mwazithunzi zopanda pake za insulin ya munthu. Kupezeka m'malo mwa amino acid katsitsumzukwa ndi glycine pa 21 malo A ndi unyolo ndikuwonjezera awiri arginine amino acid mu B unyolo ku terminal amino acid.

Mankhwalawa amapangidwa ndi kampani yayikulu yopanga mankhwala ku France - Sanofi-Aventis. Popita maphunziro ambiri, zidatsimikiziridwa kuti insulin Lantus sikuti imangochepetsa chiopsezo cha hypoglycemia poyerekeza ndi mankhwala a NPH, komanso imathandizira kagayidwe kazachilengedwe.

Pansipa pali malangizo achidule ogwiritsa ntchito ndi kuwunika kwa odwala matenda ashuga.

Chithandizo cha Lantus ndi insulin glargine. Amapezeka ndi majini obwezeretsanso pogwiritsa ntchito mtundu wa k-12 wa bakiteriya Escherichia coli. M'malo osaloŵerera, samasungunuka pang'ono, mu acid acid sing'anga imasungunuka ndikupanga microprecipitate, yomwe imatulutsa insulini pang'onopang'ono. Chifukwa cha izi, Lantus ali ndi mbiri yosavuta kuchitira mpaka maola 24.

Kupanga kwakukulu pa pharmacological:

• Ochepa adsorption ndi mbiri yopanda kanthu mkati maola 24.
• Kuponderezedwa kwa proteinolysis ndi lipolysis mu adipocytes.
• Gawo lolimbikira limamangirira ma insulin receptors maulendo 5-8 mwamphamvu.
• Kukuwongolera kagayidwe kachakudya kagayidwe kachakudya, kuletsa shuga kupangika kwa chiwindi.

Mu 1 ml Lantus Solostar muli:

• 3.6378 mg wa insulin glargine (malinga ndi 100 IU ya insulin ya anthu),
• 85% glycerol
• madzi a jakisoni
• hydrochloric wozama acid,
• m-cresol ndi sodium hydroxide.

Kuchita ndi mankhwala ena

Pali mankhwala omwe amakhudza kagayidwe kazakudya, pomwe akuwonjezera kapena kuchepetsa kufunika kwa insulin.

Chepetsa shuga: pakamwa antidiabetesic othandizira, sulfonamides, ACE zoletsa, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Onjezani shuga: mahomoni a chithokomiro, diuretics, sympathomimetics, kulera kwapakamwa, zotumphukira za phenothiazine, proteinase inhibitors.

Zinthu zina zimakhala ndi mphamvu ya hypoglycemic komanso hyperglycemic. Izi zikuphatikiza:

• beta blockers ndi mchere wa lithiamu,
• mowa
• clonidine (antihypertensive mankhwala).

Kusintha kupita ku Lantus kuchokera ku insulin ina

Ngati munthu wodwala matenda ashuga agwiritsa ntchito ma insulin apakatikati, ndiye kuti musinthana ndi Lantus, muyezo ndi mtundu wa mankhwalawo umasinthidwa. Kusintha kwa insulin kuyenera kuchitika kokha kuchipatala.

Ngati NPH insulins (Protafan NM, Humulin, etc.) anali kutumikiridwa 2 pa tsiku, ndiye kuti Lantus Solostar amagwiritsidwa ntchito nthawi imodzi.

Nthawi yomweyo, kuti muchepetse chiopsezo cha hypoglycemia, mlingo woyambirira wa insulin glargine uyenera kukhala wocheperako ndi 30% poyerekeza ndi NPH.

M'tsogolomu, dokotala amayang'ana shuga, njira yodwalayo, kulemera kwake ndikusintha kuchuluka kwa mayendedwe omwe amaperekedwa. Pakatha miyezi itatu, kugwiritsa ntchito bwino kwa mankhwalawa kungayang'anitsidwe ndikusanthula kwa hemoglobin ya glycated.

malangizo:

Insulin Lantus pa nthawi yapakati

Maphunziro a zachipatala a Lantus omwe ali ndi amayi apakati sanachitike. Malinga ndi zomwe sizinalembedwera, mankhwalawa samakhudza kwambiri mayendedwe a mwana komanso iyemwini.

Kuyesa kunachitika pa nyama, pomwepo zimatsimikiziridwa kuti insulin glargine ilibe vuto la kubereka.

Lantus Solostar woyembekezera atha kutumikiridwa pokhapokha insulin NPH isagwire ntchito. Amayi amtsogolo akuyenera kuwunika shuga wawo, chifukwa mu trimester yoyamba, kufunika kwa insulin kumatha kuchepa, komanso mu trimester yachiwiri ndi yachitatu.

Osawopa kuyamwitsa mwana; malangizo ake alibe zomwe Lantus imatha kudutsa mkaka wa m'mawere.

Momwe mungasungire

Alumali moyo wa Lantus ndi zaka 3. Muyenera kusungira m'malo amdima otetezedwa ndi kuwala kwa dzuwa pa kutentha kwa madigiri 2 mpaka 8. Nthawi zambiri malo abwino kwambiri ndi firiji. Poterepa, onetsetsani kuti mwayang'ana kutentha, chifukwa kuzizira kwa insulin Lantus koletsedwa!

Kuyambira koyamba kugwiritsa ntchito, mankhwalawa amatha kusungidwa kwa mwezi umodzi m'malo opanda pake kutentha osaposa 25 digiri (osati mufiriji). Osagwiritsa ntchito insulin yomwe yatha.

Komwe mugule, mtengo

Lantus Solostar amalembedwa mwaulere ndi mankhwala ndi endocrinologist. Komanso zimachitika kuti wodwala matenda ashuga ayenera kugula yekha mankhwala ku pharmacy. Mtengo wamba wa insulin ndi ma ruble 3300. Ku Ukraine, Lantus angagulidwe 1200 UAH.

Odwala matenda ashuga akuti ndi insulin yabwino kwambiri, kuti shuga yawo imasungidwa mwa malire. Nazi zomwe anthu akunena za Lantus:

Ambiri adangotsala ndemanga zabwino zokha. Anthu angapo adanena kuti Levemir kapena Tresiba ndiwofunikira.

Insulin lispro - malangizo, mtengo, ndemanga ndi analogi mankhwala

Lizpro insulin ndi mawonekedwe a insulin ya anthu. Choyambitsa chachikulu cha mankhwalawa ndi kuyamwa kwa kagayidwe kazakudya. Komabe, ili ndi katundu wa anabolic (amalimbikitsa kukula kwa minofu). Poyerekeza ndi insulin yomwe ikukonzekera, Lizpro insulin imayamba mwachangu komanso kutha kwake.

Kupanga ndi mawonekedwe a kumasulidwa

Lyspro insulin - njira yowoneka bwino yotsekera mkati ndi mkati mwa makonzedwe, imakhala ndi: • Chofunikira chachikulu: insulin lispro - 100ME, • Zinthu zothandizira: glycerol (glycerin), zinc oxide, metacresol, sodium hydrogen phosphate heptahydrate, 10% hydrochloric acid solution ndi / 10% sodium hydroxide solution, madzi.

Kulongedza. Makatoni asanu a 3ml m'matumba kapena ma cartridge atatu a 3ml mu zolembera za QuickPen syringe. Malangizo, mapaketi a makatoni.

Zotsatira za pharmacological

Lizpro insulin ndi mtundu wina wa DNA womwe umapanganso insulin. Amasiyana motsatizana kwa lysine ndi proline amino acid zotsalira pamalo 28 ndi 29 a insulin B. Amatha kukopa kayendedwe ka glucose metabolism, ali ndi anabolic katundu.

Imathandizira kusintha kwa glucose ndi ma amino acid kulowa mu khungu, kumalimbikitsa kupangika kwa glycogen kuchokera ku glucose mu chiwindi, kumalepheretsa gluconeogeneis, kulimbikitsa kusintha kwa glucose owonjezera kukhala mafuta. Insulin yamunthu ndiyofanana.

Ili ndi poyambira kuchitapo kanthu mwachangu kuposa ma insulini ena a anthu, chiwonetsero cham'mbuyomu cha nsapato, nthawi yochepa yogwira ntchito ya hypoglycemic.

Kuyambanso mwachangu (mphindi 15 pambuyo pa jekeseni) kumalumikizidwa ndi kuyamwa mwachangu, komwe kumakupatsani mwayi kuti mulowemo musanadye, pomwe insulin yovomerezeka yamunthu iyenera kuperekedwa pakadutsa mphindi 30. chakudya chisanachitike. Masamba a jakisoni amakhudza kuchuluka kwa mayamwidwe, komanso momwe zimayambira. Kuchuluka kwa kanthu ndi maola 0,5 - 2,5, nthawi yayitali ya maola 4.

Zizindikiro zogwiritsidwa ntchito

1. Akuluakulu ndi ana ochokera zaka 2 zokhala ndi matenda amtundu wa 1.
2. Type 2 shuga mellitus (pankhani ya kulephera kwa mapiritsi).