Mndandanda wa mankhwala abwino kwambiri m'gulu la fibrate kuti muchepetse cholesterol yamagazi

Matendawa ndi matenda omwe pafupifupi aliyense amadziwa. Sizosadabwitsa, chifukwa asayansi ena amachitcha kuti mliri wa 21st. Zowonera pakalipano zikusonyeza kuti pafupifupi gawo limodzi mwa anthu atatu okalamba akudwala cholesterol yayikulu, zomwe zingayambitse matenda monga atherosulinosis. Cholesterol yotsika kwambiri imasonkhana ndikuyika makhoma m'mitsempha yamagazi, ikuchepetsa kuwala kwawo ndikuwononga khoma. Zomwe zimapangitsa izi ndizosavuta komanso banal - zakudya zopanda thanzi, moyo wotsika.

Mankhwala amakono samayima - mumsika wamankhwala muli mankhwala osiyanasiyana omwe amapangidwa kuti athane ndi cholesterol. Lero tikambirana za ma fibrate - mawonekedwe a mankhwalawa, mndandanda wam'badwo watsopano wa mankhwalawa ndi momwe amagwirira ntchito.

Kodi ma fiber ndi momwe amachitira

Muzipatala ndi ma profid apamwamba a lipid, mankhwala a magulu otsatirawa amapezeka nthawi zambiri - fibrate ndi ma statins. Nkhaniyi imatsatila gulu loyamba.

Mitengo ndi mankhwala omwe ali michere ya fibroic acid.

Njira yamachitidwe fibrate ndikuletsa kupangika kwa ma lipoprotein otsika komanso ochepa kwambiri m'chiwindi. Kuphatikiza apo, michere imathandizira kuchotsedwa kwa cholesterol yoyipa m'thupi. Mothandizidwa ndi mankhwalawa:

• kuchuluka kwa zotengera kumayenda bwino,
• Kuchulukana kwa khoma lamankhwala kumakulirakulira,
• Zizindikiro za cholesterol yayikulu m'magazi zimachepetsedwa.

Mankhwala opatsirana bwino ndi ofunikira phindu pamaso pa mankhwala otsitsa lipid. Uku ndi kuthekera kolimbikitsa kuwonjezeka kwa kapangidwe kachulukidwe kakakulu ka lipoproteins (HDL) ndi kuchepa kwa triglycerides. Monga mukudziwa, gawo la lipid ndi "cholesterol yabwino", ndipo limakhudza bwino dongosolo la mtima. Awo kupanikizika kwambiri m'mwazi kumachepetsa mwayi wokhala ndi kupititsa patsogolo kwa matenda aheroscosis.

Malinga ndi radar, njira yayikulu yopanga michere ndi mapiritsi. Pulogalamu yawo yogwira, lipoprotein lipase, imayenda nayo ku chiwindi ikalowa m'magazi, yomwe imayambitsa kachulukidwe kake kakakulu ka lipid.

Zoyenera kudziwa: Ma fiber sachiritsa zotsatira za njira za atherosselotic ndipo sangathe kuchotsa kale cholesterol m'makoma amitsempha. Mankhwalawa amangolepheretsa kugawa kwawo, kukula, komanso kupangika kwatsopano kwa kulowetsedwa ndikuwonongeka kwamafuta. Ichi ndichifukwa chake kudziwika koyambirira ndi chithandizo chamanthawi yake ndikofunikira.

Zizindikiro zogwiritsidwa ntchito

Pendani Mapiritsi amapatsidwa ntchito madokotala omwe ali ndi vuto la lipid metabolism. Cholinga chachikulu cha chithandizo ndikuchepetsa kapangidwe ka cholesterol. Chifukwa chake, kuchuluka kwa LDL m'magazi kudzachepa ndipo kuchuluka kwa HDL kukwera. Mauphatikizidwe awiriwa ndi otsutsana, ndipo cholesterol yapamwamba imalepheretsa zowonongeka zazoyipa (kutsika kochepa).

Kuphatikiza apo, kukonzekera kwa fibrate kudzatsogolera ku triglycerides yachilendo m'magazi, ndipo nthawi zambiri kusamala kachitidwe ka mafuta kagayidwe m'thupi. Mankhwala amtundu uliwonse pagululi ali ndi zake zomwe akufotokozera.

Mndandanda wamankhwala abwino kwambiri am'badwo watsopano

Mankhwalawa ndi yogwira ntchito zotumphukira za fibroic acid. Agawika m'mibadwo itatu, iliyonse yomwe imaperekedwa pamsika wamasitolo pansi pa mayina osiyanasiyana ogulitsa.

• Nthonje za m'badwo woyamba: clofibrate
• Fibates of 2 mibadwo: gemfibrozil, bezafibrat
• Fiber za m'badwo wachitatu: fenofibrate, ciprofibrate

Fenofibrate

Awa ndi mankhwala a m'badwo wotsiriza, wachitatu. M'mawu azachipatala, tsopano amatha kupezeka pafupipafupi pakati pa michere ina yonse. Amakhala ndi mbiri yotereyi chifukwa cha malo omwe amalembedwera - imalepheretsa kudziphatika kwa magulu ambiri am'magazi komanso tizigawo ting'onoting'ono ta magazi, tomwe timachepetsa kwambiri ngozi yamagazi. Njira yayikulu yochepetsera lipid-kuchepetsa, monga ma fiber ena, ndikuti imakhudza gawo loipa la cholesterol ndi LDL, kuchepetsa kuphatikizika kwake m'chiwindi ndipo, nthawi yomweyo, kumathandizira kukulira kwa cholesterol ya HDL - "yothandiza".

Ngati tikufanizira fenofibrate ndi mankhwala amibadwo ina, ndiye kuti ili ndi zowerengeka zazing'ono zomwe zimapangitsa. Kwambiri bioavailability komanso mosavuta digestibility. Mlingo waukulu patsiku ndi 200 mg. Ndikofunikira kumwa mankhwalawa mukudya. Mwanjira imeneyi, kuyamwa kwathunthu kwa mankhwalawa kumachitika.

M'mafakisi, omwe amafanana ndi omwe amagwira ntchito omwewo amaperekedwa, pansi pa mayina Lipantil, Tricor, Nolipax, Lipofen, Fenofibrat Canon.

Bezafibrat

Amapangidwa m'mapiritsi ndi muyeso wa 200 milligrams. Mosiyana ndi fenofibrate, iwo amatengedwa asanadye. Njira ya chithandizo ndi mwezi umodzi, ndiye kuti nthawi yopuma imapangidwa nthawi yofanana. Mankhwala awa a gulu la fibrate amadziwika ndi kukhudzika kwakukulu komanso kutulutsa msanga m'thupi.

Pamashelu ogulitsa mankhwala osokoneza bongo amathanso kupezeka pansi pa mayina a brand Besifal, Cedur, Oralipin.

Choline Fenofibrate

Ndi mankhwala osokoneza bongo omwe mwachindunji mu minofu amasinthidwa kukhala fenofibroic acid. Amalembera odwala omwe ali ndi mtundu wa III, IV ndi V hypercholesterolemia (malinga ndi gulu la Fredrickson). Mlingo wambiri watsiku ndi tsiku ndi 135 mg. Zosagwirizana ndi mowa.

Itha kupezeka pansi pa dzina la malonda la Trilipix.

Awa ndi mankhwala am'badwo woyamba wa fibrate. Pakadali pano, sigwiritsidwanso ntchito chifukwa chotsatira zoyipa zambiri. Kugwiritsa ntchito kwake kungayambitse cholestasis ya impso, mapangidwe amiyala mu hepatobiliary system ndikuchulukitsa kwa cholelithiasis.

Komanso motsutsana ndi kumbuyo kwa nthawi yoikidwiratu, minofu yam'mimba imavutika. Izi zimawonetsedwa ndi zotupa zosiyanasiyana za neuromuscular, myositis ndi myalgia. Odwala amatha kudandaula za kutopa kwakumbuyo, kufooka, ndi zizindikiro za kuledzera. M'mbuyomu (makamaka kumapeto kwa zaka za zana la 20), adalembera odwala omwe ali ndi zotupa za atherosulinotic zam'mimba, zotumphukira, komanso ziwongo.

Mayina amalonda amitundu yamtunduwu: Lipomid, Amotil, Lipavlon, Miskelon.

Waprofibrate

Mankhwalawa ali ndi zosiyana zingapo pamagulu ake a zamankhwala - amasintha momwe cholesterol imapangidwira. Izi zimachitika chifukwa chophwanya kapangidwe ka mevalonic acid mu chiwindi (mevalonic acid ndi pakati pakati pa cholesterol mapangidwe). Zotsatira zake, cholesterol yathunthu, zigawo zake zotsika komanso ma triglycerides zikuchepa kwambiri. Ndipo HDL, mosiyana ndi izi, ikukula. Amagwiritsidwa ntchito pokhazikika komanso zogwirizana ndi endo native hypercholesterolemia, komanso pazikhalidwe zomwe mankhwala ena sangathe kupirira. Dzinali limatchedwa Lipanor.

Malangizo ogwiritsira ntchito

Monga zinthu zina zotsitsa lipid, ma fiber ayenera kutengedwa pokhapokha atakumana ndi katswiri. Zolemba mu malangizo ogwiritsira ntchito zilipo kutengera mtundu wa mankhwala ndi mibadwo yake. Mankhwala a m'badwo wachitatu amatengedwa ndi zakudya, ena onse asanadye. Pafupipafupi kuvomerezedwa ndikuchokera kamodzi mpaka katatu patsiku.

Ganizirani zotsutsana ndi zoyipa za mapiritsi a cholesterol ogwira mtima awa.

Zotsatira zoyipa ndi contraindication

Ziphuphu ndi mankhwala omwe amakhudza thupi. Chifukwa chake, amasankhidwa ndi dokotala wokhazikika atamuwunika kwathunthu. Asanaikidwe, muzikumbukira zolakwika zingapo pagululi, izi:

• Mafayilo sagwiritsidwa ntchito pochita ana. Amaphatikizidwa kwa ana.
• Pa nthawi yoyembekezera komanso mkaka wa m'mawere, mankhwalawa samapangidwanso, popeza ali ndi mphamvu ya teratogenic ndipo amatha kulowa mkaka wa m'mawere.
• Hypersensitivity zimachitika mankhwala kapena zigawo zake.
• Odwala omwe ali ndi vuto la chiwindi kapena matenda a impso, makamaka ndi kulephera kwa aimpso.
• Odwala Omwe Amamwa Mowa Mopitirira Muyeso
• Odwala omwe ali ndi mbiri ya pancreatitis yovuta kapena yopweteka.

Ma fiber achilengedwe kulibe, onsewa ndi zinthu zopangidwa ndi mankhwala. Chifukwa chake, monga chinthu chilichonse chopangidwa, michere imakhala ndi zotsatira zoyipa. Komabe, ngati m'badwo wawo woyamba, mndandanda wazotsatira unali masamba angapo a malangizo, ndiye kwa omaliza, m'badwo wachitatu iwo unachepetsedwa kwakukulu komanso kutalika. Pamodzi ndi mankhwala ena am'badwo uno, Fenofibrate nthawi zambiri amadziwitsidwa ndi madokotala. Pogwiritsa ntchito chitsanzo chake, timaganizira zovuta zakubadwira m'badwo uno.

Kuwerengetsa kwamawonekedwe kunapangidwa chifukwa cha kutenga Fenofibrate. Phunziroli lidakhudza odwala 4389. Mwa iwo, odwala oposa 90% sanamve zotsatira zoyipa za mankhwalawa. 8,9% ya omwe adafunsidwa adazindikira kusasangalala kwam'mimba. 1.1% - kumva kufooka kwa minofu ndi kupweteka pamutu pang'ono. Kuphatikiza pazotsatira zoyipa izi, malangizo a ma fibrate amawonetsa zovuta zingapo zosowa - kuchepa kwa hemoglobin m'mitsempha yamagazi ndi zotupa pakhungu.

Kusiyana pakati pa ma fibrate ndi ma statins

Fibates ndi ma statin ndi magulu awiri osiyanasiyana a mankhwalawa, omwe ali ndi mitundu yosiyanasiyana yochitira zosiyanasiyana. Chifukwa chake, kufunsa funso - lomwe limakhala labwino, ma fiber kapena ma statin - silolondola. Kusiyanitsa kofunikira kwambiri pakati pa ma fiber ndi kuthekera kachitidwe pa triglycerides. Ili ndiye gulu lokhalo lamankhwala lomwe likuwonetsa katunduyu.

Ma Statin ndi mankhwala omwe cholinga chake ndi kuchepetsa kuchuluka kwa cholesterol “yoyipa” ndikuwonjezera “zabwino”. Zitha kuwoneka kuti ma fiber amapanga zomwezo. Koma ayi, ma statins amachita mwachindunji pama cell a chiwindi ndikuletsa ma enzymatic machitidwe omwe amathandizira kapangidwe ka cholesterol. Ndi ma fibrate - imathandizira kuchotsedwa kwa cholesterol yoyipa m'magazi ndikuchepetsa kuchuluka kwa triglycerides.

Zaka zaposachedwa, kafukufuku wa asayansi aku London adawonetsa kuti ma statins amakhudza mtima weniweniwo, amawongolera kapangidwe kake ndi ntchito zake. Pansi pa zochita zawo, kuchuluka kwa mtima wama hypertrophy kumachepa kwambiri. Musaiwale za momwe zimakhalira pakuyenda kwamitsempha yamagazi - kutanuka kwake kumachuluka, khoma lamitsempha limalimbitsa, ndipo mwayi wokhala ndi kachulukidwe kolesterol kokhazikika pa iwo umachepa kwambiri.

Malinga ndi mawerengero azachipatala ndi machitidwe, chithandizo chamankhwala cha statins chimachepetsedwa kwambiri cholesterol ikafika chizindikiro cha 7.4 mmol pa lita. Ngati lonjezoli lakwaniritsidwa mu mbiri ya lipid, ndiye pazochitika zonse, adokotala ayenera kupanga mankhwala ovuta ndi mitundu ingapo ya mankhwala. Nthawi zambiri, kuphatikiza kwa ma statins okhala ndi ma fibrate kumayikidwa.

Madokotala malingaliro

Akatswiri azachipatala amalankhula mofatsa za ma fiber. Osati pachabe, chifukwa mankhwalawa amapezeka pafupipafupi m'mawu awo. Amachepetsa cholesterol yamagazi, ndi othandiza kwambiri. Malinga ndi kafukufuku, mukamagwiritsa ntchito mankhwala omwe amachokera mndandanda wa mafupa, monga fenofibrate kapena gemfibrozil, odwala ali ndi chiopsezo chodwala matenda a mtima.

Chifukwa chake, fibrate ndi mankhwala omwe amalimbana ndi cholesterol yayikulu. Amasankhidwa kokha ndi akatswiri pazisonyezo zina ndipo amagulitsidwa m'mafakitore pokhapokha ngati mwalandira mankhwala. Zothandiza kuchokera ku fibroic acid ndi gawo limodzi mwa zovuta pa matenda a atherosulinosis. Kuphatikiza apo, awa ndi mankhwala akuluakulu komanso osagwirizana polimbana ndi kuchuluka kwa triglycerides m'magazi a odwala.

Gemfibrozil

Hypolipidemic wothandizira wa gulu la fibrate la m'badwo wa II. Amapezeka ndikufufuza zinthu zochepa za poizine wa clofibrate. Zotsatira zake, wovulaza wotsika kwenikweni komanso wosagwiritsa ntchito bwino yemwe adapezeka yemwe amachepetsa kupanga ndi kuchuluka kwa lipids atherogenic. Amapezeka mu mawonekedwe a makapisozi a 0,3 ga kapena mapiritsi a 0,45 g yogwira ntchito.

Monga lamulo, mlingo woyambirira wa mankhwalawa umayamba pa mapiritsi 2 patsiku. Kulandila kumachitika bwino kwambiri mphindi 30 mpaka 40 musanadye, kuti mayamwidwe azikhala ochuluka. The achire zotsatira zimachitika pambuyo 1-2 milungu kudya wokhazikika. Kuchuluka kwake kumatheka pambuyo pa masabata anayi, pambuyo pake mphamvu zazikulu zimapitilira. Mwa zina zomwe zingachitike chifukwa chotenga:

• nseru
• chizungulire
• kutopa,
• kugona
• thupi lawo siligwirizana
• kuwonongeka kwakanthawi kwakanthawi.

Mankhwala contraindicated mu mimba ndi mkaka wa m`mawere, ana osaposa zaka 18, pamaso pa matenda a impso ndi chiwindi. Mtengo wapakati mumafakitale aku Russia ndi ma ruble 1,500 pakompyuta iliyonse ya mapiritsi 30.

Zotsatira zoyipa za mankhwala am'badwo watsopano

Ngakhale mankhwala akupita kukathetsa kwathunthu mavuto obwera chifukwa cha kumwa mankhwala, mpaka pano, Fenofebrat ndi woimira m'badwo wachitatu wa gulu la fibrate, adakali ndi zovuta zina, zomwe zimawonedwa pafupifupi 10% ya odwala. Chimodzi mwazomwe zimachitika ndizosasangalatsa pamimba, kumva kutopetsedwa m'mimba, komanso kugaya chakudya.

Zotsatira za zoyipa pambuyo pakutenga ma fupa a mibadwo ya III.

Pafupifupi 1 mwa 100 odwala adzakumana ndi mavuto monga:

• kufooka kwa minofu
• mutu
• nseru
• kuchepa kwa hemoglobin m'magazi,
• pang'ono totuwa khungu.

Osowa kwambiri muzochitika zachipatala pakhala pali milandu yotsuka tsitsi, kukula kwa chiwindi. Pankhaniyi, mankhwalawa amayimitsidwa nthawi yomweyo.

Fibates kapena statins - ndibwino?

Statins ndi lipid-kuchepetsa mankhwala opangidwa kuti athetse matenda a lipid kapena, mopepuka, kuti achepetse kuchuluka kwa "cholesterol yoyipa" ndikuwonjezera gawo la "cholesterol yabwino". Ngakhale zofanana ndi izi, mfundo ya ma statins ndi yosiyana ndi ma fiber.

Statins imagwira maselo a chiwindi, kutseka ma michere omwe akukhudzidwa ndi kapangidwe ka cholesterol, chifukwa chake kupanga kwake kumachepetsedwa kwambiri. Statin imalimbikitsanso mitsempha ya magazi, imapangitsa kuti ikhale yodalirika, komanso kuchepetsa mwayi wokhala ndi zigawo za atherogenic lipid pamakoma.

Kafukufuku ku mayunivesite aku London adawonetsa kuti kuwonjezera pa zovuta zonse zomwe zafotokozedwa pamwambapa, ma statins amasintha kapangidwe kake ndi kagwidwe ka mtima. Anthu omwe amamwa mankhwalawa pafupipafupi samakhala ndi mwayi wokuwona kuchuluka kwa minofu ya mtima, komwe ndi chizindikiro cha kufooka kwa minofu. Mpaka pano, kuti muchepetse cholesterol, ma statins a m'badwo wa 3 ndi 4 amagwiritsidwa ntchito: Atorvastatin ndi Rosuvastatin.

Kusiyana kwakukulu pakati pa ma fibrate ndi ma statins potengera zakale pamlingo wa triglycerides. Kugwiritsa ntchito ma statins, komanso mankhwala ena omwe alipo masiku ano, sikungalepheretse kwathunthu chitukuko cha atherosulinosis ndi zotsatira zake, ndipo pakubwera mphindi pamene mwayi wa ma statins utatha, ndikusintha kowonjezereka kwa ma doses ndi zinthu zomwe sizikuyenda kumabweretsa zotsatira zabwino zamankhwala.

Malinga ndi machitidwe azachipatala, kuthekera kwama statins kumatha mphamvu ya cholesterol ya 7.4 mmol / l kapena kuposa. Pazowonetsa pamwamba pamtunda uno, madokotala mosakayikira amapereka mankhwala angapo, nthawi zambiri ma statin amagwiritsidwa ntchito molumikizana ndi ma fibrate.Chifukwa chake, kunena kuti ndi mankhwala ati omwe ali bwino sikutheka.

Zopanga Zopanga

Wopanga ndiye kampani yopanga mankhwala Hexal. Ichi ndi chimodzi mwazigawo za Novartis Corporation, yomwe imakhala yachiwiri padziko lonse lapansi molingana ndi kuchuluka kwa mankhwala opangidwa. Likulu - Novartis ili ku Switzerland.

Mfundo zochizira odwala omwe ali ndi hyperlipidemia

Cholinga chachikulu cha chithandizo cha odwala omwe ali ndi hyperlipidemia ndikukwaniritsa mulingo woyenera wa cholesterol yonse, otsika komanso okwera kwambiri lipoprotein cholesterol, triglycerides. Ntchito ya dotolo ndikuwunika momwe wodwalayo alili komanso kuthekera kwa zovuta zochokera mu mtima.

Pachiwopsezo chochepa komanso chapamwamba, kusintha kwakukulu pamakhalidwe ndi zakudya kumasonyezedwa. Yalimbikitsa:

• Kuchepetsa kudya zamafuta, kuwerengetsa mosamala kalori, kutsatira mfundo za zakudya zoyenera (nthawi zina izi zimangokwanira kukonza kuchuluka kwa cholesterol ndi ma atherogenic lipids)
• kusewera masewera: ndi kunenepa kwambiri, muyenera kuyamba ndi katundu wochepa kuti musawononge mafupa, mtima dongosolo, etc.,
• kusiya zizolowezi zoipa.

Chifukwa cha njira zopanda mankhwala ku USA, Finland ndi Australia zaka zopitilira 40, kufa kwa matenda a mtima apatsika ndi 50%.

Komabe, ndizosatheka kuyambitsa zinthu zina zowopsa (zokhudzana ndi zaka, kutengera kwa chibadwa). Pakanalibe zotsatira kuchokera ku njira zosagwiritsa ntchito mankhwalawa, mankhwala ena akuwonetsedwa. Lowetsani:

• ma statins
• otsatizana a bile acid,
• nicotinic acid
• mafupa.

Ngati monotherapy singabweretse zotsatira zomwe mukufuna, akulangizidwa kumwa mankhwalawa nthawi imodzi.

Mankhwala

Makina a Bezafibrat ndi ovuta:

• imathandizira kusweka ndi chidziwitso cha lipoprotein yotsika kwambiri chifukwa cha kuyambitsa kwina lipoprotein lipase,
• Imachepetsa ntchito ya enzyme acetyl-CoA carboxylase, yofunikira popanga bile acid,
• timapitiriza excretion wa mafuta m'thupi ndi ndulu.

Mothandizidwa ndi mankhwalawa, kuchuluka kwa ma triglycerides amatsika mpaka 50%, zomwe zimakhala ndi cholesterol yonse ndi LDL cholesterol - mpaka 25%. Madotolo awona kuwonjezeka kwa kuchuluka kwapachulukirapo lipoproteins.

Kuphatikiza apo, Bezafibrat:

• amachepetsa kuchuluka kwa uric acid,
• amachepetsa kupanga mapuloteni C omwe timagwira,
• amachepetsa milingo ya fibrinogen.

Ntchito ya Anticoagulant ndi fibrinolytic imatheka chifukwa chochepetsa kuchuluka kwa michere ndi michere. Chifukwa chake, kugwiritsidwa ntchito kwa Bezafibrat ndi njira yodalirika yopewera matenda a thrombosis komanso matenda amtima wotsatira ndi stroko.

Zambiri pazomwe zimagwira

Chaposachedwa, makina a shebfibrate adaphunzira mwatsatanetsatane. Thupi limagwira ntchito pazigawo zama cellular, kuyambitsa ma α-receptors enaake (PPAR-α). Chifukwa chake, kuwongolera kapangidwe ka ma apoproteins ndi makutidwe ndi okosijeni amafuta amachitika. Chidacho chimakhala ndi zotsatira zabwino pamagawo osiyanasiyana a lipid ndi lipoprotein metabolism.

Pazonse, ma isoform angapo a PPAR receptors amafotokozedwa - α, β / δ ndi γ. Zimapezeka m'misempha yosiyanasiyana ndipo mtundu uliwonse umakhala ndi ntchito yakeyake. PPAR-í imakhala makamaka pachiwindi, minofu, minofu ya adipose, impso ndi mtima. Udindo wake ndikulimbikitsa mtundu wamapuloteni omwe amachititsa kuti lipids lipangidwe komanso and-oxidation wamafuta acids.

Nthawi zambiri, PPAR pamlingo wamtundu imasungitsa malire pakati pa makutidwe ndi okosijeni amafuta mu hepatocytes (PPAR-α receptors "amachititsa" njirayi) ndi kudziunjikira kwawo mu adipocytes (chifukwa cha ntchito ya PPAR-γ). Uku ndi kuwongolera pakati pakusunga ndi kuwononga mphamvu m'thupi la munthu.

Asayansi apeza kuti PPAR-α imathandizira pakukula kwa hyperlipidemia ndi zovuta zina zama metabolism. Ndipo, potero, zotsatira za bezafibrat pa receptor iyi zimatithandizanso kutengera mawonekedwe a lipid mbiri. Komabe, kagwiritsidwe kofananako ka mankhwalawo kinafotokozedwera pambuyo pokhazikitsidwa muzipatala.

Zisonyezo za kumwa mankhwalawa

Bezafibrat imalembedwa mitundu ina ya hyperlipidemia (nthawi zambiri III, IV, V, koma malinga ndi dokotala, itha kugwiritsidwa ntchito ngati mitundu ina ya matenda). Nthawi zambiri, mankhwalawa amadziwitsidwa pakalibe chifukwa chazakudya kapena kulimbitsa thupi kapena nthawi yomweyo kwa odwala omwe ali pachiwopsezo cha matenda a mtima.

Zoletsa ntchito

Pokhudzana ndi zovuta za pharmacokinetics, mndandanda wa zotsutsana pakutenga Besafibrate umaphatikizapo:

• Matenda oopsa a chiwindi, chikhodzodzo ndi matenda a biliary (kusiyanitsa ndi lamuloli ndi kuchepa kwamafuta a chiwindi),
• Matenda a impso,
• ana ndi achinyamata osakwana zaka 18,
• tsankho limodzi pazigawo zake.

Kuphatikiza apo, kugwiritsa ntchito mankhwalawa kumakhala kochepa panthawi yapakati. Komanso, pakudya, kuyamwitsa kuyenera kusiyidwa.

Mawonekedwe a ntchito ndi mlingo

Mlingo umasankhidwa payekha kwa wodwala aliyense. Nthawi zina, kuphatikiza chithandizo kumasonyezedwa. Chothandiza kwambiri ndi kuphatikiza kwa Bezafibrate ndi mankhwala ochokera ku gulu la statin odwala omwe ali ndi triglycerides okwera kwambiri. Kuphatikizikaku kumachepetsa kwambiri ngozi yakukula kwa mtima wamavuto omwe ali ndi odwala matenda ashuga komanso kunenepa kwambiri.

Zotheka zimachitika

Mosiyana ndi mafupa am'badwo woyamba, mankhwalawa amaloledwa bwino. Kutenga mapiritsi sikuchitika limodzi ndi zotsatira zoyipa.

Komabe, malangizowa akufotokoza zovuta zotsatirazi:

• nseru, kangapo - kusanza,
• kupweteka kwam'mimba
• matenda amkuwa
• chisangalalo
• kupweteka kwa minofu
• kuchepa kwa kugonana,
• alopecia.

Kuphatikiza apo, kugwiritsa ntchito kwa Bezafibrat kungasinthe magawo a kuyezetsa magazi ndi zamankhwala ambiri (kuchepa kwa hemoglobin, maselo oyera a magazi, kuchuluka kwa ma enzymes a chiwindi, ndi zina zambiri).

Kuchita ndi mankhwala ena

Chenjezo liyenera kuchitidwa panthawi yomweyo ndi omwe ali ndi magulu awa:

• Ma Anticoagulants (coumarin, etc.), kuphatikiza mankhwala omwe si a antiidal anti-yotupa - zotumphukira za salicylates, butadiene. Bezafibrat imawongolera zochita zawo, zomwe zimawonjezera mwayi wotulutsa magazi mosazungulira.
• Madera. Kusankhidwa kwa Mlingo payekha ndikofunikira chifukwa cha chiopsezo cha rhabdomyolysis (kwambiri matenda, limodzi ndi kuwonongeka kosasintha kwa maselo a minofu).
• Antidiabetic (hypoglycemic) mankhwala. Bezafibrat amasintha mphamvu ya minyewa kukhala glucose, yomwe imafunika kusintha kwa mlingo.
• Machirowa. The mwayi kwamikodzo thirakiti mavuto.

Chifukwa chake, ndikofunikira kudziwitsa adokotala pasadakhale za mankhwala omwe adamwa komanso mtsogolo kuti agwirizanitse kuthekera kwa zovuta mankhwala.

Malangizo apadera

Mosamala, mapiritsi a Bezafibrate amaperekedwa kwa odwala omwe ali ndi acidity ya chapamimba ndipo amatsogolera zotupa ndi zotupa zam'mimba. Komanso, munthawi yonse ya chithandizo, kuwongolera kwa mawonekedwe a lipid ndi magawo a kuchipatala ndikofunikira. Kuphatikiza apo, kupenda kwapafupipafupi kwama ultrasound kumalimbikitsidwa.

Tsiku lotha ntchito

Ndi zaka 3 kuyambira tsiku lomwe adatulutsa.

Kuchotsera chithandizo kwa mankhwala kumachitika monga momwe adanenera dotolo atatha kusintha kwa mawonekedwe a lipid.

Mpaka pano, Bezafibrat akupezeka ku Europe kokha.

M'dziko lathu, madokotala amatha kupereka mankhwala ena kuchokera ku gulu la fibrate:

Komabe, madotolo amalimbikitsa Bezafibrat chifukwa chotsimikizika ndi zamankhwala komanso mbiri yabwino ya chitetezo.

Mtengo wa mankhwalawo komanso momwe mungagule

Bezafibrat sinalembetsedwe pagawo la Russian Federation, koma ku Europe silingagulidwe kulikonse. Pali mankhwala omwe amagulitsidwa ku Germany kokha, kuchokera komwe makampani apakatikati amapereka.

Panganoli likhoza kubweretsedwa ku Moscow, St. Petersburg ndi m'mizinda ina ya Russia. Mtengo wa mankhwalawa umatengera muyeso wa chinthu chomwe chikugwira ndipo ndi pafupifupi ma euro 70 pa paketi ya 0,2 g ndi ma euro 80 - 0,4 g.

Madokotala amafufuza

Tatyana Stepanovna Vinnitskaya, katswiri wamtima: “Hyperlipidemia ndi mliri wa munthu wamakono. Kukhala moyo wongokhala, zizolowezi zoyipa, kuperewera kwa zakudya m'thupi nthawi zambiri kumabweretsa vuto lofananalo kuposa kubereka komanso zinthu zina. Dokotala nthawi zambiri amafunsidwa ngati zizindikiro za matendawo zimakhudza kwambiri moyo wa wodwalayo. Mwa zina mwa mankhwala a hypolipidemic, Bezafibrate amadziwika kuti ndi mankhwala othandiza kwambiri komanso osasintha. "

Ndemanga za Odwala

Julia, wazaka 34: "Kukhala moyo wongokhala komanso chizolowezi chogwira ntchito" yolimbikitsa "kunapangitsa kuti pakhale zotsatira zomveka - kunenepa kwambiri ndi zotsatirapo zake zonse monga kupumira, kuthamanga, ndi kudumphira magazi. Ndinapita kwa adotolo, ndipo mwa mayeso ena angapo mayina a lipid adalembedwa. Zotsatira zake zinkayembekezeranso. Bezafibrat adalimbikitsidwa kwa ine. Ndamwa mankhwalawa kwa nthawi yayitali, ndazindikira kuti zimachitika mwachangu, sizinachitike. ”

Momwe mungasiyanizire zabodza

Muzipatala za ku Russia sipangakhale choyambirira, popeza mankhwalawo sanagulitsidwe mwalamulo mdziko. Woyimira pakati agula mankhwalawo ku Germany kenako akukonzekera kupita ku adilesi yosonyezedwa ndi kasitomala.

Nthawi yomweyo, pofuna kuonetsetsa kuti mankhwalawa ali abwino, munthu ayenera kupempha chiphaso. Ndikofunikanso kuyang'anira chidwi cha dzina pa phukusi ku dzina lapadziko lonse la mankhwalawo.

Zotsatira zakuchipatala

Mayeso akuluakulu azachipatala adachitidwa kumapeto kwake. Mayesowa adawunika chiyembekezo cha nthawi yayitali chogwiritsa ntchito ma fiber. Zotsatira zake, cholesterol yathunthu yatsika ndi 10%, cholesterol cholesterol otsika kachulukidwe - ndi 11%. Nthawi yomweyo, kuchuluka kwa cholesterol mkulu osalimba lipoproteins kuchuluka ndi 15%. Kuchepa kwa milingo ya triglyceride ya 35% kunadziwikanso. Zotsatira zake, kuchuluka kwa anthu omwe amafa chifukwa cha matenda a mtima adatsika ndi 26%.

Kufufuza kukupitirirabe. Akatswiri ali ndi chidwi chofuna kuphatikiza mankhwala osokoneza bongo omwe amachepetsa lipid.

Ndondomeko yolandirira

Mapulogalamu apadera a mankhwala apangidwa. Koma pochita, mlingo umasankhidwa payekha kwa wodwala aliyense, kutengera momwe alili, mawonekedwe a hyperlipidemia, komanso momwe angayankhire. Zomwezi zimagwiranso nthawi yayitali ya chithandizo.

Migwirizano yogulitsa m'mafakisi

Bezafibrate sagulitsidwa ku Russia, kotero kukhalapo kapena kusapezeka kwa chilolezo kuchokera kwa dokotala zilibe kanthu. Ku Europe, mankhwalawa amatha kugulidwa ndi mankhwala a dokotala. Kupeza mankhwala omwe amapereka mankhwala popanda chikalatachi ndizovuta kwambiri komanso zopusa ndi kupeza zabodza.

Chifukwa chake, kupita kukalandira mankhwala kudzidalira nokha, muyenera kulandira mankhwala ochokera kwa dotolo ndi matchulidwe achi Latin a dzina la mapiritsi. Ngati sizotheka kugula nokha mankhwalawo, mutha kupempha thandizo kwa mkhalapakati wodalirika.

Zotsatira za pharmacological

Bezafibrat ali ndi antiaggregatory (kuchepa kwa mphamvu ya thrombosis), hypoglycemic (kutsitsa glucose), lipid-kutsitsa (kutsitsa cholesterol) ndi antiatherosranceotic pharmacological action.

Bezafibrat imawonjezera ntchito ya michere yomwe imakhudzidwa ndi kagayidwe ka lipids (mafuta), kuphatikizika (kugawanika) kwa mafuta mu lipoproteins yotsika-mapuloteni (mapuloteni ovuta omwe amalumikizidwa ndi mafuta). Mankhwala amalepheretsa kufalikira kwa lipids, amachepetsa kuyatsidwa kwa akaphatic monobasic carboxylic acids ndi mpweya wotseguka wa kaboni ndikupanga lipids mu chiwindi.

Zimalepheretsa kaphatikizidwe kachulukidwe kakang'ono kwambiri ka lipoprotein ndikukulitsa kuchuluka kwa kuyeretsedwa kwa iwo. Imachepetsa ntchito ya enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (coenzyme A) reductase. Enzyme iyi imathandizira kapangidwe ka cholesterol, chifukwa chake ndichofunikira kwambiri pa mankhwala antissteotic (kuphatikiza Bezafibrat).

Bezafibrate imalepheretsanso kapangidwe ka mevalonic acid, kamene HMG-CoA imabwezeretsa. Imachepetsa zomwe zimakhala ndi lipids, cholesterol yathunthu (makamaka, lipotrotein cholesterol), koma imachulukitsa zomwe zili lipoproteins zapamwamba (HDL3 ndi HDL2).

Amachepetsa kukhathamira kwa magazi pogwiritsira ntchito ma plates amomwe amachititsa hemostasis - thromboblasts. Pa chifukwa chomwechi, amachepetsa kuchuluka kwa fibrinogen m'magazi. Imachepetsa kupitilira kwa atherosulinosis ndi kuwonongeka kwa mtima wamagazi.

Chitani masewera olimbitsa a vegetative vascular dystonia

Kwa zaka zambiri osavutika ndi CHOLESTEROL?

Mutu wa Bungwe: “Mudzadabwa momwe zimakhalira zosavuta kuchepetsa mafuta m'thupi mwakumwa tsiku lililonse.

Vestative-vascular dystonia - kuzindikira kwakeko ndikosamveka komanso kwachikale. M'magulu amakono a matenda, palibe. Ndilondola kwambiri kunena osati za matenda a vegetovascular dystonia (ili ndi lingaliro losamveka bwino), koma la zovuta zina zakudya.

Kuchepa kwa Autonomic sikuti matenda odziyimira pawokha, koma chisonyezo chokhacho chomwe chikuwonetsa kusokonezeka pakugwira ntchito kwa dongosolo laumwini la autonomic, lomwe limayang'anira njira monga kupuma, kugunda kwa mtima, kugaya chakudya, komanso kukhalabe ndi magazi athanzi.

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Anthu omwe ali ndi vuto la ubongo wamanjenje amakumana ndi zovuta zambiri: mutu, chizungulire, palpitations, kupweteka mumtima, nkhawa, ndi manja akunjenjemera. Awa ndi mawonekedwe "otchuka kwambiri" a vegetovascular dystonia, ndipo ponse pali oposa zana a iwo. Matenda a mtima, kusintha kwa mahomoni m'thupi, matenda am'mimba, mavuto ndi dongosolo lamanjenje ndipo zina zambiri zitha kukhala chifukwa chodwala.

Kupewera kwa michere-misempha dystonia imaphatikizapo masewera olimbitsa thupi. Kukhala moyo wongokhala kumalepheretsa dongosolo la mtima, kumachepetsa mphamvu ya mtima komanso kumayambitsa mavuto obwera chifukwa cha mantha am'thupi. Chithandizo cha matenda oyambitsidwa sichikhala chokwanira popanda maphunziro akuthupi.

Kugwiritsa ndi Mlingo

Mankhwala ayenera kumwedwa katatu patsiku kwa mapiritsi 1 / 1.5 (0,2 g) musanadye masiku 20-30.

Mapiritsi a retard (ogwiritsa ntchito nthawi yayitali) - piritsi limodzi (0,4 g) kamodzi patsiku.

Ngati ndi kotheka, njira ya mankhwalawa imatha kubwerezedwa, mutakambirana ndi dokotala.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwala a Bezafibrat amapezeka m'matumba a zidutswa 50 kapena 100. Mapiritsi okhazikika - 0,2 g, kubweza (kugwiritsa ntchito nthawi yayitali / yayitali) - 0,4 g.

Chofunikira chachikulu cha Bezafibrate ndi 2-4-2- (4-chlorobenzoyl) aminoethylphenoxy-2-methylpropanoic acid (C19H20ClNO4), yochokera ku fibroic acid.

Malinga ndi nomenclature yapadziko lonse - 2- (b-para-chlorobenzoylaminoethyl) phenoxy-2-methylpropionic acid.

Gulu la mankhwala omwe Besafibrate ndi ake ndi mafupa.

Kuchita ndi mankhwala ena

Imawonjezera mphamvu ya anticoagulants osalunjika (mankhwala omwe amachepetsa kugwa kwamagazi). Kuphatikiza ndi zoletsa za enzyme HMG-CoA reductase (mwachitsanzo, ndi lovastatin ndi ma statins ena) kungayambitse rhabdomyolysis (kuwononga maselo a minofu minofu).

Ndiye chifukwa chake ndikofunikira kuwunikira thanzi lanu pamene mukumwa mankhwalawa, ndipo ngati mukumva kupweteka kapena kufooka minofu, siyani kumwa.

Zotsatira zoyipa

Kuchepetsa mseru, matenda a anorexia, kusanza, kutsekula m'mimba, michere yambiri (michere yomwe imapangitsa kuti pakhale ubale pakati pa chakudya ndi mafuta metabolism) m'magazi, kuchepa magazi (kuchepa magazi), leukopenia (kuchepa kwa maselo oyera amwazi - maselo oyera am'magazi), cholestasis (kuchepa kwa magazi bile mu duodenum, myopathy (aakulu minofu matenda), kusabala, osiyanasiyana thupi lawo siligwirizana.

Mankhwala osokoneza bongo a Bezafibrat amawopseza ndi poyizoni ndikuwonetsa zotsatira zoyipa, makamaka dyspeptic, choncho onetsetsani kuti mwakumana ndi katswiri wokhudza mlingo woyenera wa mankhwalawo.

Contraindication

Hypersensitivity, chachikulu biliary cirrhosis, tsankho la zinthu zomwe zimapanga mankhwalawa, matenda oopsa a chiwindi (kupatula mafuta onenepa), impso, chikhodzodzo, chotupa ndi msambo.

Mankhwala osavomerezeka kwa ana.

Mankhwala Bezafibrat amalimbikitsidwa kuti asungidwe m'malo owuma, otetezedwa ku kuwala ndi ana.

Mtengo wapakati wamapiritsi amtundu wa retard (ntchito yayitali) ku Russia - 3000 ma ruble.

Mtengo wapakati ku Ukraine - 760 hryvnia.

Zofanizira za Bezafibrat ndi Bezamidin, Bezalin, Bezifal, Difaterol, Oralipin, Zedur.

Kumbukirani kuti mutha kusankha mankhwala oyenera komanso oyenera kwa inu pokhapokha mutakambirana ndi katswiri.

Kufotokozera Mwachidule

Mankhwala Bezafibrat amagwiritsidwa ntchito pochiza matenda osiyanasiyana a metabolic ngati chakudya ndi masewera olimbitsa thupi sizimabweretsa zotsatira. Chifukwa cha zovuta zake zamankhwala, Bezafibrat imalepheretsanso matenda amitsempha yama mtima ogwirizana ndi kapangidwe ka magazi ndi kutsekeka kwa mitsempha yamagazi.

Kuchita bwino kwa mankhwalawa kumachitika chifukwa chakuti amachitika pa enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (coenzyme A) reductase. Ili ndiye puloteni yomwe imathandizira kapangidwe ka cholesterol, motero mankhwala ambiri a antisulinotic amakhala ndi cholinga chake.

Nthawi zambiri, mulingo woyenera kumwa ndi 0,2-0.3 g katatu patsiku musanadye kapena 0,4 g kamodzi patsiku (mapiritsi achire, i.e. mapiritsi a nthawi yayitali kapena yayitali).

Ndikofunikira kukonzekera kuchuluka kwa mankhwalawa omwe amamwa nthawi yomweyo ndi bezafibrate, chifukwa amathandizira zotsatira za anticoagulants osadziwika, komanso kuphatikiza ndi zina za HMG-CoA reductase inhibitors zingayambitse rhabdomyliosis, matenda omwe maselo amisempha ya minofu yaumunthu amawonongeka.

Mankhwalawa ali ophatikizika mwa amayi apakati komanso oyembekezera, ana ndi anthu omwe ali ndi matenda oopsa a impso, chiwindi, ndulu, komanso anthu omwe ali ndi vuto lililonse laumwini kapena mankhwala athunthu.

Kuphatikiza pa matenda ammimba, mavuto omwe amabwera chifukwa cha kupukusa kwam'mimba - kusanza, kusanza, kutsegula m'mimba, kuchepa kwa magazi, kusokonekera kwa kuchuluka kwa magazi ndi kuchuluka kwa magazi - kuchepa kwa magazi, leukopenia, ndi zina zotere.

Mukamalandira chithandizo ndi Bezafibrat, musaiwale za kadyedwe, masewera olimbitsa thupi omwe ali oyenera kwa inu ndikuwunika momwe thupi lanu limayendera - kuwunikira kwakanthawi komanso kupita ku chipinda cha ultrasound kungakupulumutseni ku matenda a gallstone ndi zotsatira zina za mankhwala a Bezafibrat.

Mfundo zachikhalidwe za physiotherapy mu IRR

Kuchita masewera olimbitsa thupi pogwiritsa ntchito micros-vascular dystonia ndi njira yosavuta komanso yothandiza yochotsera zizindikiro za matendawa. Thupi lanu litayamba kulandira kuchuluka kwa zinthu zolimbitsa thupi, mtima ndi mantha zimayamba kukhala m'malo olondola: kuthamanga ndi kusintha kwa mtima kosakhazikika, kufooka ndi zosasangalatsa zomwe zimachoka, malingaliro amasintha kukhala abwino.

Mitundu yamitundu yomwe ili yoyenera kwa anthu omwe ali ndi vegetovascular dystonia:

• kuyenda mwachangu
• kusambira
• madzi aerobics
• kuyendetsa njinga
• kuvina
• aerobics (yopanda magetsi),
• zolimbitsa thupi (zolimbitsa thupi),
• Tabata (njira zingapo)
• Yoga

Kukhala mukuchita masewera olimbitsa thupi kuti mulimbitse mtima, muyenera kudziwa muyeso. Ziwonetsero zolimbitsa thupi sizingatheke kupindulitsa thupi losakonzekera. Kuchita masewera olimbitsa thupi mu michere-misempha dystonia kumatanthauza katundu wokhazikika komanso wopanda katundu. Kuchita zolimbitsa thupi kwambiri kungayambitse chizungulire, kupweteka mutu, kapenanso kukomoka mwa munthu wokhala ndi michere ya misempha.

Ngati mumalowera m'nyumba, iyenera kupuma bwino. Ngakhale mutayang'ana kwambiri zolimbitsa thupi, musaiwale za kupuma, osagwirizana.

Musaiwale za masewera olimbitsa thupi a m'mawa! Ndikokwanira kuchita masewera olimbitsa thupi m'mawa kwa mphindi 15. Pambuyo pake kuyenera kukhalabe kumverera kwamphamvu, osati kutopa. Ngati mutachita masewera olimbitsa thupi matendawa akuchulukirachulukira, yesetsani kuchepetsa katundu ndi kukaonana ndi dokotala.

Ndikofunika kuti muyamba ntchito iliyonse ndikuyenda. Mukatentha, musamayende mwadzidzidzi, ndikusinthana mikono ndi miyendo ndi matalikidwe akulu. Kukula kwa maphunzirowo kuyenera kukula pang'onopang'ono. Pamapeto pa gawoli, samalani ndikupuma komanso kupuma.

Sikoyenera kusunga mbiri mwatsatanetsatane ya kukakamiza, kugunda kwa mtima ndi kuchuluka kwa zolimbitsa thupi zomwe zachitika. Anthu omwe ali ndi vegetovascular dystonia amakhala ndi nkhawa, choncho kudziletsa kwambiri kumatha kuwononga mkhalidwe wamanjenje. Sankhani mitundu yamasewera omwe mumakonda kuti asakubweretsereni mavuto.

Ochita masewera olimbitsa thupi okhudzana ndi VSD

Chimodzi mwazomwe zimayambitsa kusokonezeka kwazinthu zokhala ndi kuchepa kwa mpweya m'thupi. Amayamba chifukwa chotanganidwa. Zikakhala pamavuto, kupanikizika kumakwera, zimachitika pafupipafupi, ndikupuma kwambiri.

Mukawona kuti mavuto amanjenje akuchulukirachulukira, yesetsani kupuma pang'ono komanso mozama, kutsata kupuma kwanu ndi mpweya wonse. Sitingathe kuwongolera kuthamanga kwathu kapena kugunda kwa mtima, koma kuwongolera kupuma kwathu ndi njira yotsika mtengo kwa aliyense kuti abwezere matupi awo m'malo abwino.

Muyenera kuphunzira kupuma molondola. M'moyo watsiku ndi tsiku, sitigwiritsa ntchito mokwanira mapapu athu, amangogwira 20%. Masewera olimbitsa thupi amathandizira kukulitsa kuphatikizira kwa kupuma konse.

Kodi kupuma koyenera ndi chiyani? Choyamba, siziyenera kukhala zapamwamba, koma zokwanira - chifuwa, m'mimba ndi chifanizo zimakhudzidwa. Muyenera kupumira m'mphuno, mpweya wotuluka uyenera kukhala wautali kuposa mpweya wambiri. Pumulani bwino, modekha komanso mopanda kupanikizika. Pakulimbitsa thupi, pofuna kupewa kupuma movutikira, mutha kutuluka nthawi yomweyo mkamwa ndi mphuno kapena kutulutsa mphuno, ndi kutulutsira mkamwa.

Nthawi zonse zolimbitsa thupi muyenera kupumira molingana ndi momwe mayendedwe ake akusunthira. Mwachitsanzo, adaweramuka, natambasulira pachifuwa pawo ndikukweza manja - adapinda. Bent, adabweretsa manja awo pamodzi - atatopa. Chitani zovuta pamayambiriro a kudzoza. Ngati simukugwirizanitsa kuyenda ndi kupuma, kutopa kumachitika mwachangu, ndipo minyewa ndi ubongo zimasowa oxygen.

Kuchita masewera olimbitsa thupi kupuma ndi vegetovascular dystonia kumathandiza kuthana ndi pulmonary hyperventilation syndrome, yomwe imachitika motsutsana ndi maziko a kusalingalira kwamalingaliro ndipo nthawi zambiri imasokoneza odwala omwe ali ndi VSD. Zimaphatikizira zovuta za kupuma zomwe zimakhudzana ndi kulephera kupuma komanso kumverera kosowa kwa mpweya.

Seti yolimbitsa thupi yopuma imapangidwa bwino kawiri patsiku ndikukhala chizolowezi. Kuchita masewera olimbitsa thupi pafupipafupi, mudzayamba kupuma molondola, osati nthawi yamaphunziro, komanso m'moyo watsiku ndi tsiku. Mawonekedwe a thupi akhoza kukhala awa: kugona, kukhala, kuyimirira, mukadakhala kuti simumamva bwino komanso kusadodometsedwa pakupuma.

Zosankha zolimbitsa thupi kupuma:

• Kupumira movutikira kudzera pamphuno. Choyamba timapumira ndi mphuno zonse, kenako chilichonse chimasinthana (kutseka chala ndi chala). Kupuma kuyenera kukhala kosasangalatsa, kolimba, koma kopanda kumverera kosowa mpweya komanso chizungulire.
• Kupuma kwam'mimba. Timapuma kuti chifuwa chisasunthe, m'mimba timatuluka ndipo timakopeka ndikuyamba kupumira. Mutha kuyika dzanja limodzi pachifuwa chanu ndi inayo pamimba yanu kuti mudzilamulire.
• Kupuma pachifuwa. Apa timapangitsa kuti m'mimba musasunthike, timagwira ntchito ndi chifuwa. Mukamapuma, yang'anirani ndikukweza chifuwa kwambiri momwe mungathere, kwinaku mukupuma, kufinya.
• Mpweya wathunthu. Chifuwa ndi m'mimba zimakhudzidwa nthawi imodzi. Ili ndi ntchito yovuta kwambiri, iyenera kuchitidwa pamene yoyamba idalankhulidwa kale. Dongosolo la kupuma kwathunthu ndi motere: inhale ndi chifuwa, kenako ndi m'mimba, ndi kutulutsidwa motere. Adawombera mpweya kuchokera pamimba, kenako ndikumasula chifuwa.

Kuchita masewera olimbitsa thupi konse kumachitika nthawi 8-12, musadzibweretsere nokha kutopa ndi chizungulire.

Yoga ku VSD

Yoga, ngati mumachita pafupipafupi komanso mosamala, mumachepetsa zizindikiro za vegetovascular dystonia ndikuthandizira kuthana ndi zovuta za tsiku ndi tsiku. Yoga imaphatikizapo njira yolumikizirana yolimbikitsira thanzi komanso thanzi. Izi sizongokhala ndi masewera olimbitsa thupi, komanso njira yodyetsera, zopumira, ndi kusinkhasinkha.

Anthu omwe ali ndi VVD ayenera kuyambitsa makalasi a yoga pang'onopang'ono, osatengera nthawi yayitali. Ngati muli m'gulu, mverani thupi lanu, osayang'ana ena. Oyamba safunikira kuyesetsa kuti akhale ndi moyo wopumira.

Yoga yokhala ndi vesttovascular dystonia imatha kukhala ndi izi:

• Asanas (mawonekedwe apadera a thupi). Ayenera kusankhidwa kutengera mtundu wa vegetovascular dystonia. Anthu omwe ali ndi kuthamanga kwa magazi (mtundu wa VVD) umalimbikitsidwa asanasinthe, kusiya, maimidwe, kulimbitsa thupi. Dongosolo la Surya Namaskar likhala lothandiza. Pa gawo lirilonse, khalani ndi maulendo angapo opumira (atatu kapena kupitirirapo), kutengera momwe mukumvera. Odwala omwe ali ndi mtundu wanthawi yayitali wa VSD ayenera kuyamba yogwiritsa ntchito yoga (mwachitsanzo, ndi mtembo). Kuyeserera kuyenera kuphatikiza asanas ndi zokonda, koma muyenera kusamala kuti musatsike nawo kwambiri. Mphesa zokhala ndi mabotolo opotoza ndikukhala zimachita, zimasintha mawonekedwe a msana ndi chimbudzi. Ndi mtundu wa mtima wa VSD, mutha kugwiritsa ntchito mitundu yonse ya asanas, koma muyenera kuwunika kuthamanga kwa magazi ndi kukoka kwanu.

• Bandhi (kutseka kwa minofu, kukakamira kwa magulu ena a minofu). Zimathandizira dongosolo lochita bwino zamagetsi ndikusinthitsa kayendedwe ka magazi ka ziwalo zamkati. Mutha kuzigwiritsa ntchito nokha kapena kuphatikiza asanas.

• Pranayama (machitidwe opumira). Ndiwothandiza makamaka kwa anthu omwe ali ndi mtundu wa VSD. Alangizidwa kuti aziganizira za kudzoza, mosangalatsa amalowetsa mpweya m'matumba awo. Odwala oopsa kwambiri ayenera kuyang'ana kwambiri kutalika kwa mpweya, amalimbikitsidwa Chandra-bhedana pranayama.

Zochita zolingalira (kuwona momwe kupuma, kupuma, kuwonekera) ndizothandiza kwa VVD, zimawonjezera kukana kupsinjika, kupangitsa kuthamanga kwa magazi, komanso kuthetsa nkhawa.

Chifukwa chake, ndi vegetovascular dystonia, mutha kuchita pafupifupi masewera onse ndi masewera olimbitsa thupi. Mutha kusankha zochitika zomwe mzimu wagona ndikusangalala ndi zolimbitsa thupi zilizonse. Musaiwale kuti muzikhala ndi chidwi kuti mukhale ndi thanzi labwino komanso pewani zosasangalatsa - iyi ndiye mfundo yofunika kwambiri yochitira masewera olimbitsa thupi mu vegeonia.

Kukhala ndi moyo wakhama sikungathandize kuthana ndi matendawa, komanso kusiyanitsa moyo watsiku ndi tsiku, komanso malingaliro abwino ndi njira yabwino yopeweretsera matenda amanjenje ndi mtima.

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Mankhwalawa amalepheretsa magazi kuundana, kutsitsa shuga m'magazi, kutsitsa cholesterol ndikuletsa kupezeka kwa atherosulinosis.

Pambuyo polowa m'thupi, mankhwalawa amafulumizitsa zochitika za ma enzymes omwe amaphatikizidwa ndi lipid metabolism, amathandizira kuwonongeka kwa otsika osalimba a lipoproteins.

Mankhwalawa amatha kuchepetsa katundu pa chiwindi, chomwe nthawi zambiri chimachitika ndi cholesterol yayikulu. Amachepetsa kupanga ma lipoprotein otsika kwambiri ndikuyeretsa matupi awo munthawi yochepa.

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Kuphatikiza pa kuchepetsa maopoproteins otsika kwambiri, kumathandizanso lipoprotein yapamwamba. Zimathandizanso kuchulukana kwa magazi, kutsika magazi, kumapangitsa kuti mtima ukhalepo.

Ili ndi zomwe zikugwiritsidwa ntchito:

1. Hyperlipoproteinemia yamitundu yonse.
2. Hyperlipidemia.
3. Hypertriglyceridemia.
4. Kuwonongeka kwa lipid kagayidwe.
5. Kuopsa kwa kapamba.
6. Kunenepa kwambiri.
7. Kuchepetsa mphamvu ya angina kuukira.
8. Kuchepetsa chakudya chokwanira.
9. Matenda a shuga.
10. Ma syndromes a Metabolic.

Kugwiritsa ntchito mankhwalawa kumakhala koyenera pokhapokha ngati muthanso kuchita masewera olimbitsa thupi komanso zakudya zapadera. Katswiri wokhawo yemwe amatha kusankhidwa. Kugwiritsa ntchito mankhwala popanda kudziwa dokotala kungayambitse kukulira mkhalidwewo. Ngakhale zabwino, mankhwalawo ali ndi contraindication. Kuletsedwa kumwa mankhwala ngati:

• kusalolera payekhapayekha,
• chachikulu biliary cirrhosis,
• Hypersensitivity
• kwambiri ma pathologies a chiwindi (kupatula mafuta osowa),
• matenda akulu a impso
• matenda a gallbladder
• Mimba ndi kuyamwa
• ochepa.

Mukamamwa mankhwala ena limodzi, muyenera kuyang'aniridwa ndi katswiri. Fibrate imatha kupititsa patsogolo zotsatira za mankhwala omwe amachepetsa kuchuluka kwa magazi, rhabdomyosis (kuwonongedwa kwa maselo am'mimba) kumatha kuyambitsa kugwiritsidwa ntchito nthawi yomweyo ndi ma statins. Ngati mankhwala enanso amakumana, adotolo ayenera kudziwitsidwa za izi.

Ngati munthawi ya chithandizo matenda akuipiraipira, ndikofunika kulumikizana ndi achipatala.

Zofananira za mankhwala

Bezafibrat si mankhwala okhawo omwe angachepetse cholesterol komanso kupewa matenda a shuga.

Ngati ndi kotheka, mankhwalawo akhoza kutha. Mankhwalawa ali ndi ma analogue opitilira umodzi, omwe amatha kusintha, osasiyananso.

Kwenikweni, mankhwala ena amtunduwu amasiyana mu gawo lamtengo, ndipo zotsatira zake zimakhala zofanana.

Ma Analogs akuphatikizapo:

• Bezamidine - mtengo wake ndi ma ruble 400.
• Besalin - amatenga ma ruble 500.
• Difaterol - mtengo wake kuchokera ma ruble 800.
• Zedur - mtengo wake kuchokera ma ruble 500.
• Oralipin - mtengo wake kuchokera ma ruble 1000.
• Cholestenorm - mtengo wake kuchokera ma ruble 580.

Mtengo wamankhwala ungasiyane, kutengera kuchuluka ndi mankhwala. Kuti mugule ambiri mwa mankhwalawa, muyenera kupatsidwa mankhwala.

Kuvomereza kwa mankhwalawo komanso m'malo mwake kuyenera kutsimikiziridwa ndi katswiri pokhapokha ngati vutolo litha kukhala lovuta.

Kuchiza ndi mankhwalawa kuyenera kuphatikizidwa ndi masewera, zakudya zoyenera komanso kukana zizolowezi zoyipa, chifukwa zimawononga mitsempha yamagazi. Zotsatira za njira zosagwiritsa ntchito mankhwalawa zidzakulitsa mphamvu ya mankhwalawa thupi, ndipo sipangakhale zotsatira zoyipa.

Kutsatira malamulo osavuta awa okhudza mavuto azaumoyo titha kuiwalika. Ogwiritsa ntchito asiya kuwunika kambiri pompopompo za luso la zidazi.

Zambiri pazamankhwala a atherosulinosis zimaperekedwa mu kanema munkhaniyi.