Hypoglycemic mankhwala Galvus Met - malangizo ntchito

Galvus Met ndi mankhwala omwe ali ndi mankhwala omwe amadziwika kuti ndi a hypoglycemic. Amagwiritsidwa ntchito kuteteza matenda a shuga. Zomwe zimagwira ndi vildagliptin. Amapezeka piritsi.

Mankhwala ndi mtundu wachiwiri wa matenda ashuga.

• Anthu omwe adalandira chithandizo cha monotherapy kale ndi vildagliptin ndi metformin.
• Ndi monotherapy, kuphatikizapo mankhwala othandizira komanso masewera olimbitsa thupi.
• Pa gawo loyambirira la mankhwala - munthawi yomweyo ndi metformin. Izi ndizofunikira kwambiri makamaka ngati zakudya ndi zolimbitsa thupi sizithandiza.
• Kuphatikiza ndi metformin, insulin, sulfonylurea, ndi chakudya chosagwira ntchito, kuchita masewera olimbitsa thupi komanso monotherapy ndi mankhwalawa.
• Ndi sulfonylurea ndi metformin kwa odwala omwe kale adagwiritsa ntchito mankhwala othandizira awa ndipo sanakwaniritse kuwongolera glycemic.
• Imodzi ndi metformin ndi insulin yotsika mtengo mwa ndalamazi.

Contraindication

• Matenda opatsirana.
• Aliyense tsankho kwa zigawo zikuluzikulu za mankhwala.
• Ntchito zovuta za impso.
• Kutsegula m'mimba, kutentha thupi, kusanza. Zizindikirozi zitha kuwonetsa kufalikira kwa matenda a impso komanso njira zopatsirana.
• Kulephera kwa mtima, kuchepa kwa mtima ndi ziwonetsero zina za mtima.
• Kupezeka kwa matenda ashuga lactic acidosis ndi ketoacidosis, motsutsana ndi maziko a boma kapena chikomokere.
• Kuledzera.

Kuphatikiza apo, mankhwalawa ali osavomerezeka kuti azigwiritsidwa ntchito pazaka zopitilira 60 ndi achinyamata osakwana zaka 18. Odwala a mibadwo iyi amakonda kwambiri metformin.

Malangizo ogwiritsira ntchito

Mlingo umasankhidwa payekha kwa wodwala aliyense. Izi zimatengera kuopsa kwa nthendayi, kusalolera kwa zigawo za mankhwala.

Ngati kuchuluka kwa glucose sikunachepe mukamamwa mlingo waukulu wa 100 mg, ndikofunika kumwa mankhwala ena a hypoglycemic.

Kumwa mankhwalawa kumatengera zakudya. Mlingo umafunika kwa odwala omwe ali ndi chiwonetsero chokwanira cha impso. Zambiri sizingadutse 50 mg patsiku. Pazigawo zotsala za odwala, kusankha kwa mankhwalawa sikofunikira.

Zotsatira zoyipa

Ngati atagwiritsidwa ntchito molakwika, zotsatirazi ndizotheka:

• kusanza ndi kusanza,
• chizungulire
• mutu
• gastroesophageal Reflux,
• kuzizira
• kunjenjemera
• kudzimbidwa.

• kupweteka m'mimba
• achina,
• chisangalalo
• kutopa,
• kufooka
• hyperhidrosis.

Odwala ena adazindikira kakomedwe kazitsulo pakamwa pawo. Nthawi zina pamakhala chotupa cha pakhungu ndi urticaria, kupindika kwambiri kwa khungu, kumamva kuwawa mtima pakhungu, kudzikundikira kwamadzi ambiri. Ululu wophatikizika, kapamba, vitamini B akusowa.₁₂ ndi hepatitis (amazimiririka atasiya kulandira chithandizo).

Malangizo apadera

Odwala onse omwe ali ndi matenda amtundu wa 2, komanso kumwa mankhwalawa, tikulimbikitsidwa kuti azitsatira zakudya zokhwima. Zakudya za calorie siziyenera kupitirira 1000 patsiku.

Musanapereke mankhwala ndi mankhwala, muyenera kuwunika zizindikiro za chiwindi. Izi zikuchitika chifukwa cha kuchuluka kwa ntchito ya aminotransferase ndikutenga vildagliptin.

Ndi kudzikundikira kwa metformin mthupi, kukula kwa lactic acidosis ndikotheka. Izi ndizosowa kwambiri koma zovuta za metabolic. Gulu lamavuto limaphatikizapo anthu omwe adakhala ndi njala kwa nthawi yayitali kapena amamwa mowa kwambiri. Izi zikugwiranso ntchito kwa odwala matenda ashuga omwe ali ndi vuto lalikulu la aimpso.

Mimba

Galvus Met 50/1000 mg ndiwophatikizidwa mwa amayi apakati komanso oyembekezera. Palibe zambiri pakugwiritsa ntchito mankhwalawa panthawiyi.

Ngati mankhwala a metformin afunikira, endocrinologist amasankha mankhwala ena otsimikiziridwa. Pankhaniyi, muyenera kuyeza shuga wamagazi mpaka kumapeto kwa pakati. Kupanda kutero, pali chiopsezo chokhala ndi kusiyana kwa kubadwa mwa mwana. Choyipa chachikulu kwambiri, kumwalira kwa fetal ndikotheka. Kuti matenda abwinobwino achulukane, mkazi amafunika kulowetsedwa ndi insulin.

Kuyanjana kwa mankhwala osokoneza bongo

Mankhwalawa ali ndi magawo ochepa ochepetsa mphamvu ya mankhwala. Chifukwa cha izi, imatha kuphatikizidwa ndi ma inhibitors osiyanasiyana ndi ma enzyme.

Pogwiritsa ntchito munthawi yomweyo ndi Glibenclamide, Warfarin, Digoxin ndi Amlodipine, palibe mgwirizano uliwonse wachipatala womwe wakhazikitsidwa.

Galvus Meta ali ndi mitundu yambiri ya mankhwala. Ena mwa iwo ndi Avandamet, Glimecomb, Combogliz Prolong, Januvius, Trazhent, Vipidiya ndi Onglisa.

Kuphatikiza mankhwala a hypoglycemic. Kuphatikizikako kumaphatikiza zigawo ziwiri zikuluzikulu - rosiglitazone ndi metformin. Amalandira mankhwala a shuga omwe amadalira insulin. Metformin imalepheretsa kaphatikizidwe ka shuga mu chiwindi, ndipo rosiglitazone imakulitsa chidwi cha maselo a beta kuti apange insulin.

Muli gliclazide ndi metformin. Amasinthasintha shuga. Odwala odwala matenda ashuga odwala matenda a shuga, amayi apakati, omwe ali ndi vuto la hypoglycemia komanso odwala wodwala matendawa.

Kutalika kwa Combogliz

Kapangidwe ka mankhwalawa kumaphatikizapo saxagliptin ndi metformin. Amapangidwa kuti azichitira matenda ashuga amtundu wa 2. Odwala omwe ali ndi mawonekedwe a shuga omwe amadalira insulin, amayi apakati, achinyamata osakwana zaka 18. Komanso, Combogliz Prolong siikuperekedwa kwa hypersensitivity pazinthu zazikulu komanso chiwindi ndi vuto la impso.

Sitagliptin imagwira ntchito ngati gawo la othandizira a hypoglycemic. Mankhwala amateteza matenda a glucagon ndi glycemia. Imaphatikizidwa mwa anthu omwe ali ndi vuto lililonse la matendawa komanso matenda a shuga. Mankhwalawa, kupuma kwamatenda am'mimba, kupweteka kwa mutu, kupweteka kwam'mimba, komanso kukhumudwa kumachitika.

Amapezeka mu mapiritsi okhala ndi linagliptin. Imakhazikika m'magulu a shuga ndikuchepetsa gluconeogenesis. Mlingo amasankhidwa payekha.

Mankhwalawa amapangidwira mankhwala ophatikizira a 2 a shuga. Amapezeka piritsi. Ndizoletsedwa kwa anthu omwe ali ndi mtima, impso komanso chiwindi, odwala matenda a shuga komanso matenda ashuga a ketoacidosis.

Mankhwalawa amagwiritsidwa ntchito kuti azikhala ndi shuga m'magazi ndikatha kudya. Saxagliptin yomwe ndi gawo la zowongolera glucagon. Amagwiritsidwa ntchito ngati monotherapy kapena kuphatikiza ndi mankhwala ena. Odalirika mtundu 1 shuga ndi ketoacidosis.

Ndemanga za ntchito ndi zabwino. Galvus Met imalekeredwa bwino ndi odwala onse. Choyipa chokha cha mankhwalawo ndi mtengo wake wokwera. Palinso kufunikira kowonjezereka kwa kugwiritsa ntchito mankhwala ochepetsa shuga.

Zambiri pazamankhwala

Chifukwa cha vildagliptin (chinthu chogwira ntchito), zotsatira zoyipa za peptidase enzyme zimachepetsedwa, ndipo kapangidwe ka glucagon ngati peptide-1 ndi HIP kumangowonjezera.

Kuchuluka kwa zinthuzi mthupi kumakhala kwakukulu kuposa kwabwinobwino, Vildagliptin imasintha ntchito ya maselo a beta mogwirizana ndi shuga, zomwe zimapangitsa kuti mahomoni azikhala ndi shuga.

Dziwani kuti kuwonjezeka kwa ntchito za beta-cell kumadalira kwathunthu kuwonongeka kwawo. Pachifukwa ichi, mwa anthu omwe ali ndi shuga othamanga, vildagliptin ilibe vuto pa kapangidwe ka insulin.

Chithandizo chogwira mankhwalawa chimawonjezera kuchuluka kwa glucagon-peptide-1 ndikukulitsa mphamvu ya maselo a alpha ku glucose. Zotsatira zake, kuphatikiza kwa glucagon kumawonjezeka. Kutsika kwa kuchuluka kwake mkati mwakudya kumapangitsa kuti chiwopsezo cha zotumphukira za cell chikhale ndi mahomoni omwe amatsitsa shuga.

Kuphatikizika, mawonekedwe omasulidwa

Mankhwalawa ali ngati mapiritsi, omwe amaphatikizidwa. Imodzi ili ndi zinthu ziwiri: Vildagliptin (50 mg) ndi Metformin, yomwe ili ndi milingo itatu - 500 mg, 850 mg ndi 1000 mg.

Kuphatikiza pa iwo, mapangidwe a mankhwala monga:

• magnesium stearic acid,
• hydroxypropyl cellulose,
• hydroxypropyl methyl cellulose,
• talcum ufa
• titanium dioxide
• chitsulo oxide chikasu kapena chofiira.

Mapiritsi amaikidwa m'matumba a zidutswa khumi. Phukusili lili ndi matuza atatu.

Pharmacology ndi pharmacokinetics

Kuchepetsa shuga kwa mankhwalawa kumadziwika chifukwa cha zomwe zimachitika pawiri:

• Vildagliptin - imawonjezera ntchito ya masamba a pancreatic motsutsana ndi shuga wamagazi, omwe amatsogolera kaphatikizidwe ka insulin,
• Metformin - imachepetsa kuchuluka kwa shuga m'thupi mwa kuchepetsa kuchuluka kwa chakudya, kumachepetsa kaphatikizidwe ka glucose ndi ma cell a chiwindi ndikuwongolera kugwiritsa ntchito zotumphukira.

Mankhwalawa amagwiritsidwa ntchito kuchititsa kuchepa kwamphamvu kwa shuga m'thupi. Komanso, nthawi zina, mapangidwe a hypoglycemia amadziwika.

Zinapezeka kuti kudya sikumakhudza kuthamanga ndi kuchuluka kwa mankhwalawa, koma kugwiritsidwa ntchito kwa zinthu zomwe zimagwira kumachepa pang'ono, ngakhale zonse zimatengera mlingo wa mankhwalawo.

Kuyamwa kwa mankhwala osokoneza bongo kumathamanga kwambiri. Mukamamwa mankhwalawa musanadye, kupezeka kwake m'magazi kumatha kupezeka mkati mwa ola limodzi ndi theka. Mu thupi, mankhwalawa amasinthidwa kukhala ma metabolites omwe amkatulidwa mkodzo ndi ndowe.

Zizindikiro ndi contraindication

Chizindikiro chachikulu chogwiritsidwa ntchito ndi mtundu wa 2 shuga.

Pali zochitika zingapo pamene muyenera kugwiritsa ntchito chida ichi:

• mu mawonekedwe a monotherapy,
• mukumwa mankhwala a Vildagliptin ndi Metformin, omwe amagwiritsidwa ntchito ngati mankhwala athunthu,
• kugwiritsa ntchito mankhwalawa limodzi ndi othandizira omwe amachepetsa shuga ya magazi ndipo muli sulfanyl urea,
• kugwiritsa ntchito mankhwala limodzi ndi insulin,
• Kugwiritsa ntchito mankhwalawa ngati chofunikira pothandizira pa matenda a shuga a 2, pomwe zakudya zamthupi sizikuthandizaninso.

Zotsatira zakugwiritsa ntchito mankhwalawa zimawunikidwa ndi kuchepa kwakukhazikika kwa kuchuluka kwa shuga m'magazi.

Mowa kugwiritsa ntchito mankhwala sayenera:

• tsankho kwa odwala kapena chidwi chachikulu ndi zigawo za chipangizo chachipatala,
• mtundu 1 shuga
• Pamaso pa opareshoni ndi njira ya x-ray, njira yodziwira matenda a radiotope,
• ndimatenda a metabolic, ma ketoni akapezeka m'magazi,
• chiwindi kuwonongeka ntchito ndi kulephera anayamba,
• aakulu kapena owonda mtima kapena kupuma,
• poyizoni woledzera,
• zakudya zoperewera zopatsa mphamvu
• mimba ndi mkaka wa m`mawere.

Musanayambe kumwa mapiritsi, muyenera kuonetsetsa kuti palibe zotsutsana.

Zotsatira zoyipa ndi bongo

Kugwiritsa ntchito mapiritsi kungapangitse kukonzekera kwa zovuta za mankhwala, ndipo izi zimakhudza ziwalo ndi machitidwe awa:

1. Matumbo oyenda - amayamba kudwala, kumakhala kupweteka m'mimba, madzi am'mimba amaponyedwa m'munsi mwa esophagus, kutupa kwa kapamba kumatheka, kulumikizidwa kwazitsulo kumatha kuwonekera pakamwa, vitamini B akuyamba kuyamwa kwambiri.
2. Machitidwe amanjenje - kupweteka, chizungulire, manja akunjenjemera.
3. Chiwindi ndi ndulu - chiwindi.
4. Musculoskeletal system - kupweteka m'malo, nthawi zina.
5. Njira za metabolism - zimawonjezera kuchuluka kwa uric acid ndi acidity magazi.
6. Ziwengo - zotupa padziko khungu ndi kuyabwa, urticaria. Ndikothekanso kukulitsa zizindikiro zowopsa za thupi lawo siligwirizana, zomwe zimafotokozedwa ngati angioedema Quincke kapena anaphylactic.
7. Nthawi zina, zizindikiro za hypoglycemia zimawonekera, ndiko, kunjenjemera kwa malekezero apamwamba, "thukuta lozizira". Pankhaniyi, kukhathamiritsa kwa zakudya zamafuta (tiyi wokoma, confectionery) ndikulimbikitsidwa.

Ngati zotsatila za mankhwalawa zimayamba kukhazikika, ndiye kuti tifunika kusiya kugwiritsa ntchito mankhwalawa ndikupita kuchipatala.

Maganizo a akatswiri ndi odwala

Malinga ndi ndemanga za madotolo ndi odwala za Galvus Met, titha kunena kuti mankhwalawa ndi othandizira kuchepetsa shuga. Zotsatira zoyipa ndizosowa kwambiri ndipo zimayimitsidwa ndi kuchepa kwa mlingo wa mankhwalawo.

Mankhwalawa ndi a gulu la mankhwala IDPP-4, adalembetsedwa ku Russia ngati njira yothetsera matenda a shuga 2. Ndiwothandiza komanso yotetezeka, yolekeredwa bwino ndi anthu odwala matenda ashuga, siyambitsa kulemera. Galvus Met imaloledwa kugwiritsidwa ntchito ndi kuchepa kwa impso, komwe sikungakhale kwapamwamba pochiza okalamba.

Mankhwala okhazikika. Zimawonetsa zotsatira zabwino pakuwongolera shuga.

Type 2 shuga mellitus adapezeka zaka khumi zapitazo. Ndinayesetsa kumwa mankhwala ambiri, koma sizinandithandizire kwambiri. Kenako adotolo adalangiza Galvus. Ndidatenga kawiri patsiku ndipo posakhalitsa shuga adayamba kukhala wabwinobwino, koma zotsatira zoyipa za mankhwalawo zidawonekera, monga, kupweteka mutu komanso totupa. Dokotala adalimbikitsa kuti asinthane ndi kuchuluka kwa 50 mg, izi zidathandiza. Pakadali pano, matendawo ndiabwino, pafupifupi kuyiwalako za matendawa.

Maria, wazaka 35, Noginsk

Zoposa zaka khumi ndi zisanu ndi matenda ashuga. Kwa nthawi yayitali, mankhwalawo sanabweretse zotsatira zabwino mpaka dokotala atalimbikitsa kugula Galvus Met. Chida chachikulu, mlingo umodzi patsiku ndi wokwanira kuteteza shuga. Ndipo ngakhale mtengo uli wokwera kwambiri, sindakana mankhwala, ndiwothandiza kwambiri.

Nikolay, wazaka 61, Vorkuta

Zolemba kanema kuchokera kwa Dr. Malysheva zokhudzana ndi zinthu zomwe zingakhale zothandiza pamankhwala a shuga:

Mankhwalawa atha kugulidwa ku mankhwala aliwonse. Mtengo umachokera ku rubles 1180-1400., Kutengera dera.