Analogs a mapiritsi Ariescore

Ariescore (mapiritsi) Kutalika: 9

Wopanga: Ozone (Russia)
Kutulutsa Mafomu:

Tab. 10 mg, 20 ma PC., Mtengo kuchokera 374 ma ruble
Tab. 20 mg, 20 ma PC., Mtengo kuchokera ku ma ruble 510

Mitengo 60
Malangizo ogwiritsira ntchito

Mankhwalawa amapangidwa ku Russia, cholinga cha matenda a mtima. Chomwe chimagwiritsidwa ntchito ndi simvastatin mu 10 kapena 20 mg piritsi limodzi. Contraindated asanafike zaka 18.

Mndandanda wa mankhwala Ariescor

Analogue ndiotsika mtengo kuchokera ku ma ruble 313.

Wopanga: Vertex (Russia)
Kutulutsa Mafomu:

Mapiritsi 10 mg, ma PC 15, Mtengo kuchokera pa ma ruble 59
Mapiritsi 10 mg, 30 ma PC., Mtengo kuchokera 62 ma ruble

Mitengo ya Simvastatin m'masitolo ogulitsa pa intaneti
Malangizo ogwiritsira ntchito

Simvastatin ndi mankhwala ochepetsa mphamvu ya lipid opanga ku Russia. Amapezeka mu mawonekedwe a mapiritsi ndipo ali ndi chinthu chomwechi yogwiritsidwa ntchito mu 10 mpaka 40 mg. Chizindikiro ntchito matenda a mtima dongosolo.

Analogue ndiyotsika mtengo kuchokera ku ma ruble 173.

Wopanga: Krka (Slovenia)
Kutulutsa Mafomu:

Mapiritsi 20 mg, 14 ma PC., Mtengo kuchokera ku ma ruble 199
Mapiritsi 10 mg, 28 ma PC., Mtengo kuchokera 289 rubles

Mitengo ya Vasilip pamafakitale opezeka pa intaneti
Malangizo ogwiritsira ntchito

Cholowa chopindulitsa kwambiri ku Slovenia ndi mtundu womwewo wamasulidwe ndikugulitsa zinthu. Zizindikiro zazikulu zogwiritsidwa ntchito: chachikulu hypercholesterolemia kapena dyslipidemia, kuchepa kwa kufa kwa mtima ndi kuchepa kwa odwala omwe ali ndi chiwonetsero cha matenda a atherosranceotic mtima kapena matenda a shuga. Pali zotsutsana.

Analogue ndiyotsika mtengo kuchokera ku ruble 265.

Wopanga: AJonior Richter (Romania)
Kutulutsa Mafomu:

Tab. 10 mg, 14 ma PC., Mtengo kuchokera ku ma ruble a 107
Tab. 10 mg, 28 ma PC., Mtengo kuchokera ku ma ruble 202

Mitengo ya Simvastol muma pharmacistine opezeka pa intaneti
Malangizo ogwiritsira ntchito

Simvastol ndi analogue yopanga Chiromania. Amapezeka m'makatoni amtundu wa 14 ndi 28 mapiritsi. Zomwe zimagwiritsidwa ntchito ndizofanana pano, motero malangizo ogwiritsira ntchito ali ndi kusiyana kochepa chabe. Musanayambe chithandizo, timalimbikitsa kufunsa dokotala.

Kutulutsa mawonekedwe ndi kapangidwe kake

Kutulutsa kwa mawonekedwe a Ovenkor - mapiritsi okhala ndi mavalo: oyera, ozungulira biconvex (ma PC 10 kapena 30. M'matumba, pamakatoni a 10, 20, 40, 60, 80 ndi 100, 10, 14, 20, 28, 30, 40, 50 kapena 100 ma PC. M'matumba okhala ndi ma polymer, mu bokosi lamatabwa 1 la kakhadi.

Piritsi 1:

yogwira mankhwala: simvastatin - 10 kapena 20 mg,
magawo othandizira: polyethylene glycol-4000, talc, titanium dioxide, mafuta a castor, butyl hydroxyanisole, microcrystalline cellulose, ascorbic acid, lactose, citric acid, chimanga ndi pregelatinized starches, magnesium stearate, hydroxypropyl methylcellulose.

Mankhwala

Mankhwala kuchokera pagulu la statins, ali ndi lipid-kutsitsa, zoletsa HMG-CoA reductase. Kapangidwe kake kadakhala kotsekedwa mphete ya lactone, omwe amayatsidwa hydrolyzed m'thupi la munthu, ndiko kuti, ndi mankhwala.

Mphete ya lactone ma statins ali ndi chiyanjano cha enzyme HMG-CoA reductaseZotsatira zake zimalumikizana ndi gawo limodzi la cholandirira coenzyme Akomwe enzyme iyi imafikira.

Gawo la molekyu ya statin imagwira nawo ntchito yotembenuka hydroxymethylglutarate mu kupitilirazomwe zimagwirizana ndi zomwe zimapangidwa ndi ma molekyulu apakati cholesterol. Njira izi zimayambitsa kutulutsa kambiri, chifukwa cha zomwe zili mkati mwake cholesterol yafupika ndikuchulukitsa cholesterol catabolism LDL. Kuchulukitsa kwa lipid kwa mankhwalawa kumachitika chifukwa cha kuchepa kwa cholesterol yathunthu chifukwa cha cholesterol LDL. Nthawi yomweyo, kuchepa kwamlingo LDL amadalira mlingo ndipo ndiwowonjezera.

Ma Statin samakhudzana ndi catabolism ndi kaphatikizidwe wamafuta amafuta achilengedwe, chifukwa chake zimakhudza mulingo wa TG osalunjika (kenako). Malinga ndi kafukufuku, mankhwalawa amadzutsa mlingo wa HDL cholesterol mpaka 14%. Kuphatikiza pa kuchepa kwa lipid, mankhwalawa ali ndi mphamvu pa khoma lamitsempha chifukwa cha vuto la kusagwira ntchito (chizindikiro cha mawonekedwe oyamba a atherosulinosis), amateteza magazi m'magazi, ndipo amakhala ndi antiproliferative ndi antioxidant. Kuchiza ndi mankhwalawa kumayendera limodzi ndi kuchepa kwamatenda a mtima.

Pharmacokinetics

Simvastatin ali ndi mayamwidwe ambiri. Kuchuluka kwa ndende yamagazi pambuyo pakumeza kumatheka pambuyo pa maola 1.3-2.4, patatha maola 12 amatsika ndi 90%. Kuyankhulana ndi mapuloteni a plasma pafupifupi 95%.

Ili ndi mphamvu ya gawo loyambirira kudzera mu chiwindi: hydrolysis ndi mapangidwe okhudzana ndi beta-hydroxyacid, ndi ma metabolites ena ogwira ntchito omwe sanapezeke.

Kuchotsa hafu ya moyo wa metabolites yogwira ndi maola 1.9.

Amapukusidwa makamaka mu mawonekedwe a metabolites ndi ndowe (60%). Mwanjira yosakhazikika, pafupifupi 10-15% imachotsedwa impso.

Zizindikiro zogwiritsidwa ntchito

hypercholesterolemia: chachikulu hypercholesterolemia (mtundu IIa ndi IIb) mwa odwala omwe ali ndi chiopsezo chotenga matenda a coronary atherosulinosis pakagwiritsidwe ntchito ka mankhwala osagwirizana ndi cholesterol yotsika komanso njira zina zosagwiritsa ntchito mankhwala (kuchepa thupi ndi zochitika zolimbitsa thupi), kuphatikiza kwa hypercholesterolemia ndi hypertriglyceridemia zolimbitsa thupi
IHD (matenda a mtima): kuteteza kulowetsedwa kwamitsempha, kuchepetsa chiopsezo cha matenda amtima (matenda opha ziwalo kapena kuchepa kwa ischemic), imfa, kusinthanso, komanso kuchepezera kupita patsogolo kwa ziwopsezo zam'mimba.

Contraindication

matenda a chiwindi mu gawo yogwira, kuchuluka kosalekeza mu ntchito ya chiwindi michere osadziwika,
porphyria
myopathy
wazaka 18
Mimba ndi kuyamwa
kusalolera kwa aliyense pazinthu zilizonse za mankhwala, komanso mankhwala ena a statin (HMG-CoA reductase inhibitors) m'mbiri.

Wachibale (Ovenkor amasankhidwa moyang'aniridwa ndi achipatala):

kumwa kwambiri
ochepa hypotension, matenda oopsa pachimake opatsirana, kusokonezeka kwakukulu kwa endocrine / metabolic, vuto la madzi-electrolyte, kuvulala, kuchitapo kanthu pochita opaleshoni (kuphatikizapo mano) kapena zinthu zina momwe mungapangire kulephera kwakukulu kwa aimpso.
zinthu pambuyo kupatsidwa zina mu immunosuppressant mankhwala (ogwirizana ndi chiopsezo cha aimpso kulephera ndi rhabdomyolysis),
khunyu
yafupika / kamvekedwe ka minofu ya mafupa a komwe sikudziwika.

Malangizo ogwiritsira ntchito Ovenkor: njira ndi mlingo

Ovencor amatengedwa pakamwa 1 nthawi patsiku, kutsukidwa ndi madzi ambiri. Nthawi yakumwa mankhwalawa sayenera kuyenderana ndi kudya.

Asanayambe kugwiritsa ntchito Ovenkor, wodwalayo amapatsidwa zakudya za hypocholesterol, zomwe zimayenera kutsatiridwa panthawi yonse ya chithandizo.

Ndi hypercholesterolemia, tsiku ndi tsiku mlingo umasiyanasiyana 10-80 mg.

Mlingo woyambira wa hypercholesterolemia ndi 10 mg. Zolemba malire - 80 mg patsiku. Zosintha (zosankha) za mankhwalawa ziyenera kuchitika pakadutsa masabata anayi. Nthawi zambiri, mulingo woyenera kwambiri zimachitika mukamamwa mankhwala tsiku lililonse mpaka 20 mg.

Ndi homozygous cholowa hypercholesterolemia, Ovencor nthawi zambiri amapatsidwa 40 mg mu 1 mlingo kapena 80 mg mu 3 Mlingo (20 mg m'mawa ndi masana, 40 mg madzulo).

Mlingo wogwira wa Ovenkor wa matenda a mtima kapena kupezeka kwa chiwopsezo chake ndi 2040 mg patsiku. Kumayambiriro kwa mankhwalawa, 20 mg nthawi zambiri amatchulidwa, mlingo ungathe kuwonjezeka ndikupuma kwa masabata anayi. Zomwe LDL ili zosakwana 75 mg / dl (1.94 mmol / L) ndipo cholesterol yathunthu ndiyosakwana 140 mg / dl (3.6 mmol / L), mlingo umachepetsedwa.

Mlingo wambiri wa 10 mg, Ovencor amawonetsa osakwana 30 ml / min mwa odwala omwe amalephera kupweteka aimpso (CRF) (chitupa cha creatinine) kapena mankhwala ophatikizidwa ndi cyclosporine, danazole, gemfibrozil kapena ma fiber ena (kupatula fenofibrate), niacin mu lipid kutsitsa Mlingo ( mpaka 1000 mg patsiku). Pogwiritsa ntchito munthawi yomweyo ndi amiodarone kapena verapamil, mlingo wa tsiku ndi tsiku wa Ovenor sayenera kupitirira 20 mg.

Zotsatira zoyipa

kugaya kwam'mimba dongosolo: kupweteka kwam'mimba, kudzimbidwa / kutsekula m'mimba, kusefukira kwam'mimba, nseru, kapamba, hepatitis, kusanza, kuchuluka kwa michere ya chiwindi, phosphatase ya alkaline ndi CPK (creatine phosphokinase),
ziwalo zamanjenje ndi dongosolo lamanjenje: mutu, asthenic syndrome, zotumphukira za m'mimba, chizungulire, kusowa tulo, paresthesia, minyewa, kukomoka kwamaso, kusawona bwino,
immunopathological and allergic reaction: kutentha kwa moto, eosinophilia, hyperemia ya pakhungu, nyamakazi, vasculitis, angioedema, polymyalgia rheumatism, thrombocytopenia, kuchuluka kwa ESR, kusinthanso kwa mankhwala osokoneza bongo lupus ngati matenda am'mimba, urticaria, photosensitivity, kupuma pang'ono,
Dermatological zimachitika: kawirikawiri - dermatomyositis, zotupa pakhungu, alopecia, kuyabwa,
minofu ndi mafupa: kufooka, myopathy, minofu kukokana, myalgia, kawirikawiri - rhabdomyolysis,
zimachitika zina: palpitations, kuchepa magazi, kuchepa mphamvu, pachimake aimpso kulephera.

Bongo

Panalibe zizindikiro zapadera za mankhwala osokoneza bongo a Ovenkor (milandu ya kumwa mankhwala a 450 mg imadziwika).

Chithandizo: njira zomwe zingathandize kuchepetsa kuyamwa kwa chinthucho (kusanza, kugwiritsa ntchito makala), chithandizo chamankhwala motsogozedwa ndi impso ndi hepatic ntchito, ndi mulingo wa CPK.

Pankhani ya kukula kwa myopathy ndi rhabdomyolysis ndi pachimake aimpso kulephera (kuphwanya sikumachitika kawirikawiri, koma kumachitika kwambiri), Ovenkor imathetsedwa, kuyendetsa kwa diuretic ndi sodium bicarbonate kumasonyezedwa (mwa kulowetsedwa kwamitsempha). Ngati ndi kotheka, hemodialysis imachitidwa.

Rhabdomyolysis ikhoza kuyambitsa hyperkalemia, yomwe imachotsedwa ndi mtsempha wa calcium chloride kapena calcium gluconate, kulowetsedwa kwa glucose osakanikirana ndi insulin, potassium ion exchanges, kapena, m'malo ovuta kwambiri, ndi hemodialysis.

Malangizo apadera

Kumayambiriro kwa chithandizo, kuwonjezeka kwapang'onopang'ono mu michere ya chiwindi kungawonedwe.

Musanafotokozere mankhwala komanso pafupipafupi, maphunziro a hepatic ntchito ayenera kuchitika. Pafupipafupi kuyang'anira ntchito ya hepatic michere: miyezi itatu yoyamba - milungu 6 iliyonse, ndiye chaka chotsala - 1 nthawi m'miyezi iwiri, mtsogolo - 1 nthawi m'miyezi isanu ndi umodzi. Ntchito zoyeserera kuti zidziwike ntchito ya chiwindi zimachitidwanso ndi milingo yowonjezera. Ngati mlingo ukuwonjezeka mpaka 80 mg patsiku, kuwongolera kuyenera kuchitika kamodzi miyezi itatu iliyonse. Ovenkor imayimitsidwa pazinthu zomwe zikuchulukirachulukira mu ntchito ya transaminase (nthawi 3 poyerekeza ndi gawo loyambira).

Pa nthawi yoyembekezera, kuthetsedwa kwa lipid-kuchepetsa mankhwala pazotsatira za nthawi yayitali ya hypercholesterolemia sikukhudza kwenikweni.

Amayi azaka zoyambira kubereka omwe sagwiritse ntchito njira zakulera salimbikitsidwa kutenga Ovenkor.

Ndi kuchepa kwa chithokomiro ntchito (hypothyroidism) kapena pamaso pa matenda ena a impso (nephrotic syndrome) ndi kuchuluka kwa cholesterol, matenda oyamba ayenera kulandira.

Kulandila kwa Ovenkor kungayambitse kukulitsa kwa myopathy ndikuwonekera kwa rhabdomyolysis ndi kulephera kwa aimpso.

Pakakhala ululu wosaneneka, kupweteka kwa minofu, kufooka kwa minofu kapena ulesi, muyenera kufunsa dokotala, makamaka ngati zovuta izi zimayendera limodzi ndi kutentha kapena malaise. Kungoganiza za myopathy, mankhwala amasiya.

Kuti muwone kupezeka kwa myopathy, tikulimbikitsidwa kuyeza kuchuluka kwa KFK. Pazindikiritso zopweteka za kumbuyo kwa sternum, kumwa mankhwala kuyenera kuganiziridwanso.

Aries amagwira ntchito molingana ndi monotherapy ndipo akaphatikizidwa ndi bile acid sequestrants.

Dokotala amawona kutalika kwa chithandizo payekha.

Mimba komanso kuyamwa

Malinga ndi malangizo, Ovenkor imaperekedwa kwa azimayi panthawi yoyembekezera / mkaka wa m'mawere.

Pali umboni wochepa wa chitukuko cha zotheka mu akhanda omwe amayi awo adamwa mankhwalawo. Amayi a msinkhu wobereka atatenga simvastatin ayenera kugwiritsa ntchito njira zakulera. Mimba ikachitika, Ovenkor imathetsedwa nthawi yomweyo.

Kuyanjana kwa mankhwala osokoneza bongo

erythromycin, immunosuppressants, telithromycin, clarithromycin, cytostatics, antifungal othandizira (ketoconazole, itraconazole), nefazodone, fibrate, nicotinic acid mu waukulu Mlingo, HIV protease zoletsa: chiwopsezo cha myopathy,
danazol, cyclosporine, gemfibrozil ndi mafupa ena (kupatula fenofibrate), niacin, amiodarone, verapamil, diltiazem: chiopsezo cha myopathy / rhabdomyolysis,
anticoagulants ya mkamwa (fenprocoumone, warfarin): chiopsezo chotuluka magazi, kuyanʻaniridwa kwa magazi musanafike pochiritsira komanso nthawi zambiri mokwanira munthawi yamaphunziro.
digoxin: kuchuluka kwa plasma,
colestipol, colestyramine: utachepa wa bioavailability (mutha kutenga Ovencor maola 4 mutamwa mankhwalawa, pomwe kukula kwa zowonjezera kumadziwika.
madzi a mphesa (oposa 1000 ml patsiku): kuwonjezeka kwakukulu kwa milingo yoletsa kutsutsana ndi HMG-CoA reductase mu plasma yamagazi (kuphatikiza kuyenera kupewedwa).

Mafanizo a Ovenkor ndi awa: Simvalimite, Sinkard, Zorstat, Simvastatin, Holvasim, Simgal, Zokor, Simvor, Simlo, Vasilip, Simvastol.

Kufotokozera za mankhwalawa

Aries - Wothandizidwa ndi hypolipidemic kuchokera ku gulu la ma statins, choletsa wa HMG-CoA reductase. Ndi mankhwala osokoneza bongo, chifukwa chimakhala ndi mphete yotsekeka ya lactone mu kapangidwe kake, yomwe imayatsidwa pambuyo polowa m'thupi.

Kapangidwe ka kamavalidwe ka statin lactone ndikufanana ndi gawo la HMG-CoA reductase enzyme. Malinga ndi lingaliro la kupikisana kwa mpikisano, molekyu ya statin imamangiriza mbali yomweyo ya coenzyme A receptor komwe enzyme iyi imafikira. Gawo lina la molekyu ya statin imalepheretsa kusintha kwa hydroxymethylglutarate kukhala mevalonate, wapakatikati mwa kapangidwe ka mamolekyulu a cholesterol. Kuletsa kwa ntchito ya HMG-CoA reductase kumabweretsa zotsatizana zotsatizana, zomwe zimapangitsa kutsika kwa zinthu zamafuta a cholesterol komanso kuwonjezereka kwa ntchito ya LDL receptors ndipo, motero, inapititsa katemera wa LDL cholesterol (Xc).

Hypolipidemic zotsatira za ma statins zimalumikizidwa ndi kuchepa kwa cholesterol yathunthu chifukwa cha LDL cholesterol. Kuchepa kwa LDL kumadalira mlingo ndipo sikwachizere, koma kokwanira.

Ma Statin samakhudza zochitika za lipoprotein ndi hepatic lipases, sizikhudza kwambiri kaphatikizidwe ndi katemera wa mafuta aulere acids, chifukwa chake, zotsatira zawo pamlingo wa TG ndizachiwiri komanso mosazungulira kudzera pazotsatira zawo zazikulu pakuchepetsa LDL-C. Kutsika kwapakati pa TG pamankhwala omwe amapezeka ndi ma statins akuwoneka kuti kumalumikizidwa ndi ma protein a hepatocytes omwe amaphatikizidwa ndi catabolism ya STDs, yomwe ili pafupifupi 30% TG.

Malinga ndi maphunziro olamulidwa, simvastatin imakweza mulingo wa HDL-C mpaka 14%.

Kuphatikiza pa kuchepetsa lipid-kuchepetsa, ma statins ali ndi zotsatira zabwino pa endothelial dysfunction (preclinical sign of atherosclerosis oyambirira), pakhoma la mtima, atheroma state, kusintha magazi m'thupi, kukhala ndi antioxidant, antiproliferative katundu. Pali umboni kuti simvastatin imasintha ntchito ya endothelial pambuyo masiku 30 ochizira.

Kugwiritsa ntchito simvastatin kumayendera limodzi ndi kuchepa kwa pafupipafupi kwamatenda amtima, mosasamala kuchuluka koyamba kwa LDL-C.

Mndandanda wazofananira

Kutulutsa Fomu (mwa kutchuka)	Mtengo, pakani.
Aries
20 mg mapiritsi, 30 ma PC.	476
Avestatin
Machitidwe
Atherostat
Tab. 0,02 No. 30 (AVVA RUS OJSC / Sti - Med - Sorb OJSC (Russia)	232
Tb PO 0.02 No. 30 (ABVA RUS OJSC / Sti - Med - Sorb OJSC (Russia)	232
Vasilip
Tab 10mg N28 Vector (KRKA, dd. Malo atsopano / paketi. Vector (Russia)	329.60
Tab 20mg N28 Vector (KRKA, dd. Malo atsopano / paketi. Vector (Russia)	458.20
Tab 40mg N28 (KRKA - Rus LLC (Russia)	628.20
Vero-Simvastatin
Zovatin
Zokor
10mg No. 28 tabu (Merck Sharp ndi Dome, UK. England)	176
Zokor Forte
40mg No. 14 tabu (Merck Sharp ndi Dome, UK. England)	458
Tab 40mg N14 (Merck Sharp ndi Dome, UK. England)	519.90
Zorstat
SIMVAHEXAL
Tab 20mg N30 (Hexal AG (Germany)	287.10
Tab 10mg N30 (Hexal AG (Germany)	319.10
Tab 40mg N30 (Hexal AG (Germany)	484.70
Simvakard
Tab 20mg N28 (ZENTIVA a.s. Czech Republic (Czech Republic)	172
Tab 10mg N28 (ZENTIVA a.s. Czech Republic (Czech Republic)	218.80
10mg No. 28 tabu (Zentiva k.s. (Czech Republic)	242
Simvacol
Simvalimite
Simvastatin
10mg No. 30 tabu p / pl. (Borisovsky ZMP OJSC (Belarus)	38.60
20mg No. 30 tabu p / pl.o (Borisovsky ZMP OJSC (Belarus)	47.50
Tab 10mg N30 Alsi (Alsi Pharma ZAO (Russia)	53.70
Tab p / pl .. Pafupifupi 20mg N30 Alsi (Alsi Pharma ZAO (Russia)	54.50
20mg No. 30 tabu p / pl.o AVVA RUS (AVVA RUS OJSC (Russia)	68.30
10mg No. 30 tabu p / pl.o (Ozone LLC (Russia)	89.10
20mg No. 30 tabu p / pl.o (Ozone LLC (Russia)	113.80
Tab 20mg N30 (Verteks ZAO (Russia)	147.60
Tab 10mg N30 (Verteks ZAO (Russia)	207.30
Tab 20mg N20 (Hemofarm A.D. (Serbia)	257.30
Simvastatin alkaloid
10mg No. 28 tabu p / pl. (Alkaloid AO (Makedonia)	59.80
Simvastatin Zentiva
10mg No. 28 tabu (Zentiva k.s. (Czech Republic)	259.90
20mg No. 28 tabu (Zentiva k.s. (Czech Republic)	335
40mg No. 28 tabu p / pl. (Zentiva k.s. (Czech Republic)	498.70
Simvastatin Pfizer
Simvastatin Sanofi
Simvastatin * (simvastatin *)
Simvastatin-ALSI
Simvastatin-SZ
40 mg mapiritsi, 30 ma PC. (Northern Star, Russia)	91
Simvastatin-teva
Simvastatin-ferein
Simvastatin-Chaikafarma
Simvastatin mphesa
Simvastol
Tab 10mg N28 (Gideon Richter OJSC (Hungary)	197.10
Simvor
Tab po 40mg No. 30 (Ranbaxi Laboratories Limited (India)	60.10
Tab po 20mg N30 (Ranbaxi Laboratories Limited (India)	282
Simgal
Tab 10mg N28 (Aivex Pharmaceuticals s.r.o. (Czech Republic)	287
40mg No. 84 tabu (Teva Czech Enterprises s.r.r.o. (Czech Republic)	304.40
10mg No. 28 tabu (Teva Czech Enterprises s.r.o. (Czech Republic)	321.50
20mg No. 28 tabu p / pl. (Teva Czech Enterprises s.r.r.o (Czech Republic)	410
10mg No. 84 tabu p / pl. (Teva Czech Enterprises s.r.r.o (Czech Republic)	609.90
40mg No. 28 tabu p / pl. (Teva Czech Enterprises s.r.r.o (Czech Republic)	678
20mg No. 84 tabu (Teva Czech Enterprises s.r.o. (Czech Republic)	870
Tab 40mg N84 (Aivex Pharmaceuticals s.r.o. (Czech Republic)	1505
Simlo
Tab 10mg No. 28 (Ipka Laboratories Limited (India)	202.90
Tab 20mg N28 (Ipka Laboratories Limited (India)	293.60
Simplacor
Syncard
Holvasim

Mlendo wina adanenapo za tsiku lotha ntchito

Kodi Ovencor amatenga nthawi yayitali bwanji kuti awone kuti wodwalayo akusintha?
Ochita kafukufukuwo nthawi zambiri atatha tsiku limodzi adasintha. Koma izi sizingafanane ndi nthawi yomwe musinthe. Funsani dokotala wanu kuti mupeze mankhwalawa kwa nthawi yayitali bwanji. Gome ili pansipa likuwonetsa zotsatira za kafukufuku pa zoyambira kuchitapo kanthu.

Mamembala

Tsiku 1

Mlendo wina adafotokoza za nthawi yokumana

Kodi nthawi yabwino kutenga Ovenkor: pamimba yopanda kanthu, isanachitike, mutatha kapena chakudya?
Ogwiritsa ntchito mawebusayiti nthawi zambiri amati amamwa mankhwalawa pamimba yopanda kanthu. Komabe, adotolo atha kuvomereza nthawi ina. Ripotilo likuwonetsa pamene ena onse omwe adawafunsidwa amamwa mankhwalawo.

Mamembala

Pamimba yopanda kanthu

Alendo khumi ndi asanu ndi awiri anena zodwala

Mamembala	%
> Zaka 60	12

70.6%

Zaka 46-60

17.6%

30-55 wazaka

Malangizo ovomerezeka ogwiritsa ntchito

(Simvastatin) Nambala yolembetsa: LSR-002033/08
Dzina la malonda: Aries

Dzinalo Losasamala: Simvastatin * (simvastatin *)

Mlingo: mapiritsi okhala ndi filimu
Kupanga: Piritsi 1 yokutidwa ndi kanema ili
ntchito: Ariescor - 10 mg kapena 20 mg,
zokopa: microcrystalline cellulose, lactose (mkaka wa shuga), pregelatinized starch (wowuma 1500), colloidal silicon dioxide (aerosil), ascorbic acid, butylhydroxyanisole, stearic acid, magnesium stearate, opadry II (polyvinyl mowa, wakuda polyglycol, gol wachitsulo talc, utoto wazitsulo wachikasu, utoto wazitsulo, red titanium dioxide.
Kufotokozera: mapiritsi ozungulira a biconvex, ophatikizidwa ndi filimu, kuchokera ku bulauni kupita pamtundu wonyezimira komanso wonyezimira wa pinki.
Gulu la Pharmacotherapeutic: lipid-lowering agent, HMG-CoA reductase inhibitor.
Nambala ya ATX: C10AA01

Zolemba zosangalatsa

Momwe mungasankhire analog yoyenera
Mu pharmacology, mankhwala nthawi zambiri amagawidwa m'magulumagulu ndi ma analogi. Kapangidwe kazofananira kameneka kamaphatikizira amodzi kapena angapo amomwe omwewo omwe ali ndi mphamvu yothandizira thupi. Ndi ma analogi amatanthauza mankhwala okhala ndi zinthu zosiyanasiyana zogwira ntchito, koma zochizira matenda omwewo.

Kusiyana pakati pa matenda a ma virus ndi bakiteriya
Matenda opatsirana amayambitsidwa ndi ma virus, mabakiteriya, bowa ndi protozoa. Njira ya matenda oyambitsidwa ndi ma virus ndi ma bacteria nthawi zambiri imakhala yofanana. Komabe, kusiyanitsa chomwe chimayambitsa matendawa kumatanthauza kusankha njira yoyenera yomwe ingathandize kuthana ndi vuto losachedwa kudwala ndipo sizivulaza mwana.

Chifuwa ndi chomwe chimayambitsa chimfine pafupipafupi
Anthu ena amadziwa vuto lomwe mwana nthawi zambiri amakhala nalo kwa chimfine. Makolo amamutengera kwa madotolo, kukamuyeza mayeso, kugwiritsa ntchito mankhwala osokoneza bongo, ndipo monga chotulukapo chake, mwana amalembetsa kale ndi dotolo wa ana monga nthawi zambiri amadwala. Zoyambitsa zenizeni za kupuma pafupipafupi sizidziwika.

Urology: mankhwalawa a chlamydial urethritis
Chlamydial urethritis nthawi zambiri imapezeka pochita urologist. Amayamba chifukwa cha majeremusi a Chlamidia trachomatis, omwe ali ndi mphamvu ya mabakiteriya komanso mavairasi, omwe nthawi zambiri amafunikira njira yothandizira antibacterial. Imatha kuyambitsa kutupa kosakhudzana ndi urethra mwa amuna ndi akazi.

Ariescorp, malangizo ogwiritsira ntchito (njira ndi Mlingo)

Asanayambe chithandizo ndi Ovencor, wodwalayo amapatsidwa muyezo zakudya zama hypocholesterol. Mankhwala ayenera kumwedwa kamodzi patsiku, kutsukidwa ndi madzi. Ndi chakudya chamagulu, mankhwalawa sayenera kuyanjana. Mlingo wovomerezeka wa tsiku lililonse hypercholesterolemia kuyambira 10 mpaka 80 mg. Pankhaniyi, mlingo woyambira ndi 10 mg. Kusintha kwa dozi kumachitika pang'onopang'ono mwezi umodzi. Mwa ambiri odwala, mulingo woyenera kwambiri wowerengeka umachitika mukamamwa Ovenkor tsiku lililonse mpaka 20 mg.

Kwa odwala omwe ali ndi Matenda a mtima wa Ischemic kapena chiopsezo chake chokhala ndi mlingo wamphamvu wa tsiku ndi tsiku ndi 20 mg mg, ndipo woyamba ndi 20 mg tsiku lililonse. Kusintha kwa Mlingo sikuchitika kwa odwala atatha zaka 60 ndi odwala omwe amalephera kupweteka pang'ono kapena pang'ono. Ndi munthawi yomweyo makonzedwe a Ovenkoroma ndi Muerapamil kapena Amiodarone Mlingo wa tsiku ndi tsiku wa Ovenkor sayenera kupitilira 20 mg.

Kuphatikizika, mawonekedwe omasulidwa

Ariescor ndikukonzekera kophatikiza, ndiko kuti, imakhala ndi chinthu chimodzi chogwira - simvastatin. Zina zotsalazo zimagwira ntchito yothandiza: perekani misa, sinthani kusungunuka kwa mapiritsi, zomangiratu zinthu zonse wina ndi mnzake. Pokonzekera izi, cellulose, wowuma, ascorbic ndi citric acid, magnesium stearate, titanium dioxide, shuga mkaka (lactose), polyethylene glycol 4000, talc amagwiritsidwa ntchito pazolinga izi.

Ariescor ndi mapiritsi omwe amapezeka mu mitundu iwiri - 10 kapena 20 mg. Amakhala ozungulira, matte, wokutidwa ndi chipolopolo choyera.

Zotsatira za pharmacological

Mapiritsi a Ovenkor amadziwika kuti ndi opanga mankhwala. Molekyulu ya simvastatin ili ndi mawonekedwe a mphete ya lactone. Mwakutero, singathe kuyanjana ndi mafuta am'mafuta a cholesterol. Koma m'chiwindi, amadzichitira okha pakusintha kwa mankhwala. Fomu yogwira ya simvastatin ndi yofanana kwambiri ndi enzyme HMG-CoA reductase, yomwe ndiyofunikira pakuphatikizidwa kwa cholesterol. Chifukwa cha njirayi, amatenga malo ake pakukhudzana ndi mankhwala. Gawo lina la molekyu pankhaniyi limasokoneza mapangidwe a cholesterol precursor. Chifukwa cha zomwe, mamolekyu ake amachepetsa.
Thupi limayankha kutsika kwa cholesterol pakukulitsa zochitika za LDL receptors, ndikufulumizitsa kusweka kwawo. LDL ndi "yoyipa" yamafuta yomwe imathandizira kuti mapangidwe azikhala pa khoma lamitsempha yamagazi. Chifukwa chake, kutenga Ovenkor kumachepetsa chiopsezo chokhala ndi atherosclerosis.

Monga ma statins onse, Ovenkor sichikhudza zochita za ma enzyme omwe amawononga mafuta (lipases), kaphatikizidwe, komanso kuwonongeka kwa mafuta acids aulere. Chifukwa chake, kuchepa kwa kuchuluka kwamafuta osagwiritsidwa ntchito m'ndale (triglycerides, TG) ndizotheka kwambiri chifukwa chothandizidwa ndi ma cell cell a chiwindi. Amalimbikitsa kuwonongeka kwa kwapakati kachulukidwe lipoproteins, 30% yopanga TG.

Zimatsimikiziridwa kuti kugwiritsa ntchito mankhwala Ariescor:

zimakhudza bwino mkhalidwe wamkati wamitsempha yamagazi (endothelium), makoma amitsempha yamagazi,
amatulutsa magazi
ali ndi antioxidant katundu
amachepetsa kuchitika kwa mtima wamavuto.

Malinga ndi malangizo ogwiritsira ntchito ndi Ovenkor, kusintha kwa endothelium kumadziwika pakatha mwezi umodzi wowerengeka.

Mankhwala amadziwika ndi mayamwidwe abwino. Kuzindikira kwakukulu m'magazi kumachitika patatha maola 4 mutatha kumwa piritsi ya Ovenkor m'thupi. Kusintha koyenera koyamba m'magazi a cholesterol kumawonekera pambuyo pa masabata awiri.

Ambiri mwa simvastatin omwe ali ndi bile amalowa m'matumbo, pomwe amachotsera ndowe. Mtundu wosagwira ntchito wa mankhwala umapukutidwa ndi impso.

Njira ya ntchito, Mlingo

Kuchiza ndi Ovencor kumafuna chakudya musanayambe mapiritsi, komanso nthawi yonse ya mankhwala.

Mlingo wa mankhwalawa amasankhidwa payekha. Ndikulimbikitsidwa kuti muyambe kugwiritsa ntchito mlingo wocheperako, ndikuwonjezera kwake. Tinalemba pamwambapa kuti kuchepa kwambiri kwa cholesterol kumatheka masiku 28 pambuyo pa kuyamba kwa mankhwalawa. Chifukwa chake.

Mlingo woyamba wa Ovenkor ndi 5-20 mg / tsiku, ndipo kutalika kwake ndi 40 mg / tsiku. Kwa odwala omwe akutenga ma immunosuppressants, kugwiritsa ntchito simvastatin kumatha mlingo wa 5 mg / tsiku. A kwambiri aimpso kulephera, malangizo limalangiza kuyambira mlingo 5-5 mg / tsiku.

The assimilation ndi bioavailability wa mankhwala kwa thupi sizikugwirizana ndi chakudya. Mutha kumwa isanayambe / itatha / mukadya, osayiwala kumwa madzi ambiri. Chofunikira kwambiri: mapiritsi amayenera kumwa kamodzi patsiku madzulo.

Kuchita

Ndi makonzedwe apakati pa warfarin ndi anticoagulants ena ndi Avencor, mphamvu yotsirizira imalimbikitsidwa. Zimasinthanso zakumwa zoledzeretsa ku chiwindi, mankhwala omwe amawononga chiwalochi.

Chifukwa cha chiopsezo cha rhabdomyolysis, kugwiritsa ntchito mankhwalawa saloledwa:

pamodzi ndi keto, itraconazole, Mlingo wambiri wa vitamini PP,
anthu omwe amamwa mankhwala a immunosuppressive.

Madokotala analemba za kuyambika kwa rhabdomyolysis pambuyo pa limodzi la simvastatin limodzi ndi sildenafil. Mankhwalawa amagwiritsidwa ntchito kukonza kukomoka kwa erectile.

Mtengo wa Ovenkor umakhudzidwa kwambiri ndi mfundo yogulitsa. M'mizinda ndi mafakitale osiyanasiyana aku Russia, ndizosiyana kwambiri. Chifukwa chake phukusi limodzi la 10 mg limatha kulipira ma ruble 275, ndi 20 mg mlingo - kuchokera pa 419 mpaka 578 rubles.

Mu pharmacy iliyonse mutha kupeza fanizo la Ovenkor - mankhwala omwe ali ndi ntchito yomweyo, koma kwa wopanga wina. Simvastatin ndi gawo la: Simvagesal, Zokor, Simvor, Simvakard, Simvastatin, Simvastol, Simgal, Simlo, Vasilip. Kuphatikiza pa mtengo wake, mankhwalawa amasiyana mitundu yotsika mtengo. Mwachitsanzo, pali mankhwala omwe ali ndi 5 ndi 40 mg yogwira ntchito. Izi ndizothandiza ngati dokotala wakupatsani mlingo wotere.

Zinthu zomwe zidakonzedwa ndi olemba polojekitiyi
malingana ndi ndondomeko yakusinthaku.

Zotsalira zotsika mtengo za Ovenkor

Analogue ndiotsika mtengo kuchokera ku ma ruble 313.

Simvastatin ndiwopindulitsa kwambiri mankhwala aku Russia omwe ali ndi zomwezi pazomwe zimapangidwa, koma osachepera mlingo wa 10 mg piritsi limodzi. Amalandira zochizira chachikulu hypercholesterolemia ndi sekondale hyperlipidemia. Mndandanda wathunthu wazizindikiro ungapezeke pazomwe mukutsatira.

Simvastol (mapiritsi) Kutalika: 4 Pamwamba

Analogue ndiyotsika mtengo kuchokera ku ruble 265.

Analogue ndiyotsika mtengo kuchokera ku ma ruble 173.

Chuma china chakunja kwa Ovenkor, chomwe chimapindulanso kwambiri kuposa "choyambirira", ngakhale sichimasiyana kwambiri ndi izi. Contraindified mu mimba, mkaka wa m`mawere ndi mwana. Mndandanda wonse wa contraindication ukhoza kupezeka mu malangizo.