Mankhwala BAGOMET - malangizo, ndemanga, mitengo ndi analogi

Bagomet imachepetsa shuga yamtundu wa 2 shuga mwa kupondereza gluconeogeneis m'maselo a chiwindi, ndikuchepetsa mayamwidwe am'matumbo m'matumbo ndikuwonjezera kuyamwa kwake ndi minofu ndi minofu yamafuta.

Simalimbikitsa maselo a beta kuti apange insulin, chifukwa chake siyambitsa mkwiyo wa hypoglycemia.

Kuchepetsa hyperinsulinemia, kumathandizira kuchepetsa kunenepa kwa odwala onenepa kwambiri omwe ali ndi matenda ashuga. Ili ndi mphamvu ya milomo. Amachepetsa cholesterol yonse.

Bagomet mwachangu komanso yolowerera kwathunthu m'mimba. Imagawidwa mwachangu pa minofu, osalumikiza ndi mapuloteni a plasma. Imatha kuyikidwa m'magazi ofiira. Imafufutidwa ndi impso, pafupifupi popanda metabolism. Ndi matenda a impso, amatha kudzikundikira minofu yathupi.

Momwe mungatenge BAGOMET

Mlingo umayikidwa payekha kutengera glucoseemia. Mlingo woyambirira wa Bagomet 500 mg ndi mapiritsi 2-3 / tsiku. Kuti mulekerera bwino kwambiri m'matumbo, mlingo wa tsiku ndi tsiku uyenera kugawidwa pawiri.

Mlingo woyamba womwewo umaperekedwa limodzi ndi mankhwala a insulin.

Ngati ndi kotheka, onjezani msanga pang'onopang'ono, komanso nthawi yayitali mpaka masiku 15. Mulingo woyenera ndi mapiritsi 6 / tsiku (3000 mg), logawidwa pazigawo zitatu.

Kwa ana kuyambira zaka 10, mlingo woyambirira ndi 500 mg / tsiku, womwe umatengedwa madzulo chakudya. Mlingo wambiri ndi 2000 mg / tsiku (logawidwa mu 2-3 Mlingo).

Mlingo wambiri wa mapiritsi a Bagomet 850 mg 3 kwa tsiku / tsiku, mapiritsi a Bagomet 1000 mg 2 / tsiku.

Matenda a 2 a shuga, ophatikizika ndi kunenepa kwambiri, komanso osakwanira kukonzekera kwa sulfonylurea.

Contraindication

Hypersensitivity
lactic acidosis, ketoacidosis, precoma ndi chikomokere
chiwindi ndi impso
matenda akulu pachimake
opaleshoni, kuvulala (panthawiyi insulin chithandizo chikusonyezedwa)
kuledzera
mimba, yoyamwitsa
Kuunika kwa X-ray ndi radioisotope ndi othandizira ayodini
ana ochepera zaka 10.

Kufotokozera ndi malangizo a momwe mungagwiritsire ntchito mankhwala a Bagomet Plus

Uku ndikuyimira kowonekera bwino kwa othandizira a hypoglycemic omwe cholinga chake ndi pakamwa. Bagomet Plus imapezeka mu mapiritsi okhala ndi mawonekedwe, obwera ndi mawonekedwe apakati. Zosakaniza zomwe zimagwira ndi metformin hydrochloride ndi glibenclamide. Nazi mawonekedwe awo achidule komanso mfundo zomwe zingagwiritsidwe ntchito mthupi lomwe lakhudzidwa:

Katundu woyamba, yemwe ali mgulu la gluuanide, kutsitsa shuga, amachepetsa mayamwidwe am'mimba m'magawo am'mimba, amasokoneza gluconeogenesis m'chiwindi, pomwe akukonzanso kuchuluka kwa cholesterol, LDL ndi triglycerides.
Gawo lachiwiri lothandizira ndi la gulu la zotumphukira za m'badwo wachiwiri, ndipo kuwongolera ndi kuchepa kwamphamvu kwa glucose munthawi yoyendayenda kumatsimikizira kudzera mwa ma cell a pancreatic kukondoweza kwa insulin.

Bagomet Plus imakhala ndi dongosolo mthupi la anthu odwala matenda ashuga, pomwe amadziwika ndi kuchuluka kwa adsorption m'mimba. The yogwira zinthu mankhwala kufika pazipita ndende mu plasma pambuyo 2-3 maola kuchokera pakamwa makonzedwe a kamodzi. Kuola kumawonedwa m'chiwindi, metabolites yogwira imasinthidwa pang'ono ndi impso ndi mkodzo ndi bile.

Zizindikiro ndi contraindication ntchito mankhwala Bagomet Plus

Omvera omwe alipo pakali pano omwe angalandire mankhwala a Bagomet Plus ndi odwala matenda a shuga a 2. Mankhwala okhala ndi makhwala amakhazikitsidwa makamaka atakula, ndi gawo limodzi la njira zophatikizika ku matenda kapena njira yodalirika yothana ndi matenda a shuga.

Mankhwala a Bagomet Plus ali ndi ma contraindication azachipatala, omwe amayenera kuwerengedwa mosamala koyambirira kwamaphunziro. Kupanda kutero, shuga wamagazi amatha kufikira malire, ndipo wodwalayo amakhala ndi vuto la matenda ashuga ndi zina zambiri. Mwa izi, ndi koyenera kuwunikira zotsatirazi matenda ndi zina za thupi:

mtundu 1 shuga
chiwindi kapena matenda a impso,
achina,
porphyria
lactic acidosis,
uchidakwa wambiri,
matenda asanachitike opareshoni
mubwererenso matenda
zaka zopuma pantchito
mimba, nthawi yoyamwitsa.

Kuphatikiza apo, ndikofunikira kukumbukira za kuyanjana kwa mankhwala, mwachitsanzo, kugwiritsa ntchito miconazole kotsutsana. Malangizo amathandizira odwala omwe ali ndi hypersensitivity pazomwe zimagwira mu Bagomet Plus. Kupanda kutero, pamakhala zotupa, ming'oma, kuyabwa, kutupa kwa khungu. Mndandanda wazomwe zimatchedwa "zotsatira zapadera" kuchokera ku chithandizo sichitha pamenepo.

Zotsatira zoyipa ndi vuto la bongo ndi Bagomet Plus

Sikuti odwala onse ndi oyenera kuonana ndi ena, ena amafunitsitsa kukana kupitiliza maphunziro chifukwa cha zovuta. Nthawi zambiri pamakhala mseru, kusanza, kupweteka m'mimba, kusowa kwa "ndalama" zamkuwa mkamwa, erythema ndi magazi. Kukonza mlingo wa tsiku ndi tsiku sikuthandizira, chifukwa chake, pakachitika zovuta, mankhwalawo akuwonetsedwanso.

Ndi kuchuluka mwadongosolo kwamawerengero onse a Bagomet Plus, lactate acidosis imayamba m'thupi la wodwalayo ndi matenda a shuga, hemodialysis akuwonetsedwa kuti athetse. Lachiwiri silikhala loopsa la mankhwala osokoneza bongo ndi mawonekedwe a hypoglycemia. Uku ndikukumana ndi migraine komanso kugona kwambiri, kutuluka thukuta kwambiri, kugunda kwamtima kosalekeza, mantha, mantha osagwedera, kugona, kufooka, chizungulire, kusokonezeka kwa mitsempha kwakanthawi, komanso kulephera kumva. Kuti muchiritse bwino mankhwala, wodwala akuwonetsedwa poyambitsa iv 40% yankho la dextrose kapena glucagon iv, i / m, s / c.

Mlingo watsiku ndi tsiku, kugwiritsa ntchito mankhwala a Bagomet Plus

Mapiritsi amayenera kumwedwa pakamwa, pakudya, akamamwa madzi ambiri. Mlingo umakhazikitsidwa payekhapayekha pochita mayeso angapo a labotale, kuwunika shuga. Mlingo wapakati ndi piritsi limodzi kamodzi patsiku, nthawi yayitali ya chithandizo chachikulu ndi masabata awiri. Ndiye chithandizo ndi Bagomet Plus chikupitirirabe, koma ndikudzikongoletsa kwamomwe mungapangire tsiku lililonse. Mlingo wambiri wololedwa wa tsiku ndi tsiku wa Bagomet Plus ndi mapiritsi 4, ndipo mkwiyo wakewo umakhala wokwiyitsa kwambiri.

Mndandanda wa mankhwala Bagomet Plus

Ngati mankhwalawo sakugwirizana, kapena ngati pali njira yolumikizirana ndi mankhwala, madokotala amalimbikitsa kuyambitsa m'malo. Misonkho imakhalapo, koma kuwunika kwathunthu kumafunikira pasadakhale kuti afotokozere za kuchuluka kwa mankhwalawa ndikuchepetsa chiopsezo cha mavuto. Akatswiri a malangizo omwe adapatsidwa amalimbikitsa kutsatira chidwi ndi awa:

Ndemanga za Bagomet Plus

Odwala omwe ali ndi matenda a shuga nthawi zambiri amatchula mankhwala omwe amapezeka pamagulu azachipatala a pa intaneti. Iwo ati Bagomet Plus motsutsana ndi matenda a shuga a 2 ndi mankhwala othandiza omwe amasiyanitsidwa ndi kusankha kwake. Poterepa, tikulankhula za nthawi yosinthira zinthu zogwira ntchito mthupi. Zotsatira zoyipa ndi zovuta sizinawonekere mwachangu, zotsatira za chithandizo zidzatero. Kupanda kutero, mavuto azaumoyo sangapewe, ndipo m'malo mwake pakufunika ena. Chifukwa chake ndemanga za anthu odwala matenda ashuga adagawika m'magulu awiri: ena amanyoza Bagomet Plus, ena amayamika.

Ndikofunika kuzindikira padera kuti pali chiwopsezo cha zotsatila kuchokera ku Bagomet Plus, ndipo odwala ambiri akukumana ndi zovuta zotere. Amalemba kuti adasinthiratu mankhwalawo, chifukwa zinthu zomwe zinali zikuipiraipira. Chifukwa chake Bagomet Plus siyenera kukhala chifukwa chodzipangira nokha mankhwala, apo ayi kulumpha mu shuga la magazi kumaperekedwa.

Chachikulu contraindication, zoyipa zimachitika thupi

Mankhwala sangalembedwe mtundu 1 shuga mellitus, matenda ashuga, chikomokere, matenda ashuga ketoacidosis, aimpso ndi kwa chiwindi kulephera, lactic acidosis, pachimake mowa. Bagomet siyikulimbikitsidwanso kuti ikhale yovuta kwambiri ya pathological yomwe imafunikira kuyambitsidwa kwa ayodini okhala ndi zotsutsana.

Mankhwalawa ali contraindicated mu aakulu ndi pachimake zinthu, amene limodzi ndi mpweya njala, awa: mantha boma, myocardial infarction, madzi osowa madzi. Palinso zoletsa kugwiritsa ntchito mankhwalawa kwa porphyria, kugwiritsa ntchito limodzi ndi Miconazole, kutenga pakati, ndi kuyamwitsa.

Ndizotheka kuti pakumwa mankhwalawa wodwala yemwe ali ndi matenda ashuga amadzakumana ndi zovuta zosagwirizana ndi thupi: kusanza, kusanza, kupweteka kwam'mimba, kusowa chilimbikitso, kulawa kwazitsulo pakamwa, erythema. Metformin mu kapangidwe ka mankhwala nthawi zina imayambitsa kuchepa kwa mayamwidwe, lactate acidosis.

Gawo lina la mankhwala a Bagomet - Glibenclamide - amatha kuyambitsa zinthu izi:

zotupa pakhungu, kuyabwa, urticaria,
kusanza, nseru, kupweteka m'mimba,
ntchito yambiri ya hepatic transaminases,
leukopenia, hemolytic anemia, thrombocytopenia.

Mwina kuwonjezeka kwa ndende ya urea m'magazi, m'mapapo aplasia, pancytopenia, hyponatremia, disulfiram ngati zochita.

Zotsatira zamtundu wa Bagomet

Bagomet ndi mankhwala a hypoglycemic omwe amachepetsa shuga komanso kuthamanga kwake pakudya. Mankhwala sasokoneza kapangidwe ka insulin. Zina mwazotsatira zoyipa za hypoglycemia sizinakhazikike. Kuthekera kwa mankhwalawa kumawonekera pambuyo poyimitsa glycogenolysis ndi gluconeogeneis, zomwe zimapangitsa kuti glycogen chiwindi chiwindi.

Bagomet imawonjezera mphamvu ya enzyme yomwe imathandizira kapangidwe ka glycogen, imawonjezera kuthekera kwa mayendedwe a membrane a glucose. Mankhwalawa amakongoletsa kagayidwe ka lipid - ndi matenda amtundu wa 2 pali mwayi wonenepa.

Bagomet ikufananiridwa bwino ndi omwe amagwirizana nawo pankhani ya kuthamanga kwambiri komanso kotheratu.

Mukamwetsa, mankhwalawo amatengedwa nthawi yomweyo kuchokera m'mimba, chimbudzi chambiri chimafika patatha maola awiri ndi theka. Imachepetsa mwayi wamafuta omwe amapezeka pakudya. Zizindikiro za Bagomet za bioavailability ndizokwera mpaka 60% ya kuchuluka kwa mankhwala omwe amaperekedwa ku ziwalo.

Malinga ndi zotsatira za kafukufuku wa pharmacokinetic, titha kunena kuti mankhwalawa amasunthira minofu mosavuta, ndikufalikira m'madzi a m'magazi. Zigawo za mankhwala sizigwirizana ndi mapuloteni, zimatha kulowa m'magazi ofiira, koma m'magazi ndizochepa kwambiri poyerekeza ndi plasma.

Kafukufuku watsimikizira kuti mankhwalawa samapangidwira mu thupi - impso zimakongoletsa momwe zidalili. Poterepa, theka-moyo ndi maola asanu ndi limodzi ndi theka. Kutuluka kwa Bagomet kumamukwiyitsa ndi kusefukira kwa glomerular kusefukira ndi impso chiberekero, motero, odwala onse omwe ali ndi aimpso a pathologies ali pachiwopsezo.

Hafu ya moyo imachulukitsidwa, zomwe zikutanthauza kuti pamakhala chiopsezo cha kuchuluka kwa mankhwala.

Zizindikiro ndi njira yogwiritsira ntchito

Bagomet imapangidwira zochizira odwala matenda ashuga omwe ali ndi mtundu wodziyimira pawokha wa matenda komanso kunenepa kwambiri (pakalibe ketoacidosis komanso yankho losakwanira lithandizo la sulfonylureas).

Mankhwalawa adapangira kuti azigwiritsidwa ntchito mkati. Finyani piritsi lonse ndi madzi. Izi nthawi zambiri zimachitika ndi chakudya kapena zitatha. Mlingo woyambirira ndi 500-100 mg / tsiku, kutengera mlingo wa glycemia. Mutha kusintha mankhwalawa pokhapokha masabata awiri atatha kudya ndikuwunika mawonetsedwe a glycemic.

Ngati dokotala sanapange chisankho payekha pokhudzana ndi wodwalayo, ndiye kuti muyezo wowerengeka wothandizidwa ndi 1500 mpaka 2000 mg. Ndikosatheka kupitilira muyeso wokwanira. Ngati mankhwalawa akukhumudwitsa chopondacho, mutha kuthana ndi chizolowezi chatsiku ndi tsiku katatu.

Ndi zovuta mankhwala "Bagomet kuphatikiza insulin kukonzekera", muyezo Mlingo ndi 1500 mg / tsiku. Mapiritsi okhala ndi mphamvu yayitali, mulingo woyenera tsiku ndi tsiku ndi 850 mg -1000 mg. Ndi kulekerera kwabwinobwino, amayima pamalo okwanira 1700 mg / tsiku., Malire - 2550 mg / tsiku. Ndi chithandizo chovuta ndi mankhwala ena ochepetsa shuga, piritsi limodzi (850 mg kapena 100 mg) limayikidwa.

Mukukula, Bagomet imatenga zosaposa 1000 mg / tsiku. Mutha kupereka mankhwala kwaana azaka zopitilira 10. Ana, komanso achikulire, ayenera kuyambiranso maphunziro a 500-850 mg / tsiku. Muubwana, pazipita tsiku lililonse ndi 2000 mg.

Zotsatira Zogwiritsa Ntchito Mankhwala

Mphamvu ya Bagomet's hypoglycemic imapangidwira ndi sulfonamides, insulin, acarbose, mankhwala osapweteka a antiidal, ACE ndi mao inhibitors, oxytetracycline, β-blockers.

Glucocorticosteroids, GOK, epinephrine, glucagon, mahomoni a chithokomiro, ma sympathomimetics, thiazide ndi "loop" diuretics, phenothiazine ndi nikotini acid zotumphukira zimalepheretsa ntchito yake.

Kuchotsa kwa Bagomet ku ziwalo kumaletsedwa ndi cimetidine. Mphamvu yakutsitsa kwa Coumarin imachokera mu Bagomet.

Njira yothandiza kwambiri yoyeretsera thupi la poizoni ndi hemodialysis. Malinga ndi zikuwonetsa, imathandizidwa ndi dalili.

Zizindikiro zosokoneza bongo

Ngati Mlingo wa Bagomet uli pamtunda wovomerezeka, lactic acidosis yokhala ndi zotsatirapo zoyipa kwambiri ngakhale kufa. Zofanana zimachitika chifukwa cha kuchuluka kwa mankhwalawa mthupi lomwe lili ndi mavuto ndi impso. Mavuto amakula patangotha maola ochepa ndipo amakhala ndi zodziwika bwino:

Matenda a Dyspeptic
Hypothermia,
Kuphwanya miyambo yamatumbo,
Ululu pamimba
Myalgia
Kutaya kulumikizana
Kukomoka ndi matenda ashuga.

Ngati gawo limodzi la zizindikiro zomwe zatchulidwa zawoneka, Bagomet iyenera kuchotsedwa mwachangu, ndipo wolakwiridwayo ayenera kuchipatala.

Kutulutsa mawonekedwe, kapangidwe kake, malo osungira

Mapiritsi amatha kukhala ndi mawonekedwe ndi mitundu yosiyanasiyana, kutengera mulingo: yoyera, yozungulira komanso yopukutira - 500 mg aliyense, mwanjira ya makapisozi 850 mg amtundu wakuda ndi 1000 mg mu yoyera. Omalizirawo akhala ndi katundu wautali. Gawo la mafomu kumasulidwa ndi mzere wogawa ndi logo ya wopanga, womangidwa pamapiritsi onse.

Piritsi limodzi lili ndi 500 mpaka 100 mg ya yogwira pophika metformin hydrochloride kuphatikiza mawonekedwe a croscarmellose sodium, povidone, stearic acid, chimanga wowuma, lactose monohydrate.

Zipangizo zothandizira zoyambira ndi mankhwala ziyenera kuyikidwa pamalo osavomerezeka ndi ana, pamtunda wofika mpaka 25 ° C. Sungani Bagomet zosaposa zaka ziwiri.

Zizindikiro ndi fanizo la mankhwalawa

Magwirizano a Bagomet akuphatikiza mankhwala omwe gululi (mankhwala amkati mwa antidiabetic) ndi zigawo zomwe zimagwira (metformin) zimagwirizana.

Ma analogi a Bagomet ndi mankhwala omwe matenda kapena vuto limodzi limangofanana mu umboni, mwanjira iyi mtundu wachiwiri wa matenda ashuga.

Avandia
Apidra
Baeta
Glemaz
Glidiab
Glucobay,
Nyama,
Lymphomyozot,
Levemir Penfill,
Levemir Flekspen,
Multisorb,
Metamine
NovoFormin,
Phuli
Fomu,
Fomu.

Ndi chithandizo chovuta ndi mitundu ina ya mankhwala ofanana, ndikofunikira kulingalira za hypoglycemia.Mankhwalawa amatha kusokoneza mgwirizano ndikuchepetsa mphamvu ya psychomotor, chifukwa chake mukamagwira ntchito moyenera kapena mukuyendetsa, ndibwino kukana kumwa mankhwalawo. Kugwiritsira ntchito kwa Bagomet kumaphatikizapo kutsata kovomerezeka ndi zakudya zama carb zotsika zomwe zimayendetsa kudya kwa mafuta m'magazi.

Ndemanga za Bagomet

Za mankhwala a Bagomet, ndemanga za madokotala ndizabwino. Malinga ndi akatswiri, kumwa mankhwala otchuka kotere kumapangitsa kuti magazi azitha kwa maola 12. Mwayi wotere umamuwonetsa maubwino ena: mutha kuchepetsa pafupipafupi kumwa mankhwalawo, kusintha kayendedwe ka kagayidwe kachakudya. Nthawi yomweyo, kuyamwa kwa zinthu zogwira ntchito m'mimba kumakonzedwa ndipo chiwopsezo chokhala ndi zovuta zimachepa.

Kufotokozera kwa mankhwalawa sikungakhale chitsogozo chogwiritsidwa ntchito. Musanagule, muyenera kufunsa wa endocrinologist, ndipo musanamwe mankhwala a Bagomet, werengani malangizo omwe angagwiritsidwe ntchito ndi wopanga. Zambiri zokhudzana ndi Bagomet zimaperekedwa kuti zidziwidwe bwino ndi kuthekera kwake ndipo sikuti ndizitsogozo zodzipulumutsira nokha. Njira yeniyeni yochiritsira, poganizira zovuta za matenda ashuga, matenda ofanana komanso kuchuluka kwa odwala matenda ashuga, amatha kupangidwa ndi katswiri.

Zizindikiro zogwiritsidwa ntchito

Mankhwala Bagomet Plus Ntchito 2 matenda ashuga mwa akulu:
- ngati mankhwala a mzere wachiwiri osagwiritsidwa ntchito ndi njira yothandizira pakudya, masewera olimbitsa thupi ndi chithandizo cham'mbuyomu ndi metformin kapena glibencl amide,
- kusintha chithandizo chamankhwala am'mbuyomu ndi mankhwala awiri (metformin ndi glibenclamide) mwa odwala omwe ali ndi khola komanso glycemia yoyenera.

Njira yogwiritsira ntchito

Ngati ndi kotheka, pakatha milungu iwiri ndi theka chiyambireni chithandizo, muyezo wa mankhwalawa umakonzedwa malinga ndi kuchuluka kwa shuga m'magazi.
Mukamachotsa chithandizo cham'mbuyomu chophatikizira ndi metformin ndi glybeklamide, mapiritsi 1-2 a Bagomet Plus 500 mg / 2,5 mg kapena 500 mg / 5 mg (kutengera mlingo wapitawu) amatchulidwa 2 pa tsiku - m'mawa ndi madzulo.
Mulingo wambiri tsiku lililonse ndi mapiritsi 4 a mankhwalawa (500 mg / 2.5 mg kapena 500 mg / 5 mg, omwe ndi 2000 mg metformin / 20 mg glibenclamide) Mapiritsi ayenera kumwedwa ndi zakudya.

Zotsatira zoyipa

Zokhudzana ndi Metformin: nseru, kusanza, kupweteka kwam'mimba, kusowa kwa chakudya ndi chizindikiro chofala kumayambiriro kwa chithandizo ndipo nthawi zambiri amachoka okha ndipo safunikira chithandizo chapadera.
Poletsa kukula kwa zizindikirozi, tikulimbikitsidwa kumwa mankhwalawa mu 2 Mlingo, kuwonjezeka pang'onopang'ono kwa mlingo wa mankhwalawa kumathandizanso kulolerana kwake, "kukoma kwazitsulo" mkamwa, erythema, megaloblastic anemia, lactic acidosis.
Chifukwa cha glibenclamide: hypoglycemia, hypoglycemic coma (ngati dosing yophwanyidwa idaphwanyidwa komanso kudya kosakwanira), khungu limakumana ndi vuto: urticaria, kuyamwa, kuyimitsa, photosensitivity, nthawi zina, thupi limasokoneza khungu chifukwa cha zotupa. kusanza, kupweteka m'dera la epigastric, kuchuluka kwa michere ya "chiwindi", jaundopenia, leukopenia, thrombocytopenia, osowa - agranulocytosis, hemolytic anemia, pancytopenia, "antab zotsatira zomveka "mukamamwa mowa.

Mimba

Pa mankhwala ndi mankhwala Bagomet Plus ndikofunikira kudziwitsa dokotala za mimba yomwe mwakonzekera komanso nthawi yomwe mayi adzakhale ndi pakati. Pokonzekera kutenga pakati, komanso ngati muli ndi pakati pa nthawi yomwe mukumwa Bagomet Plus, mankhwalawa ayenera kuthetsedwa ndi chithandizo cha insulin.
Bagomet Plus imaphatikizidwa pakuyamwa, popeza palibe umboni wa kuthekera kwake kudutsa mkaka wa m'mawere.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mankhwalawa amapezeka piritsi. Chigawo chilichonse chimakhala ndi biconvex, mawonekedwe ooli, okhala ndi zojambula za "1000" mbali zonse ziwiri. Imakutidwa ndi chipolopolo cha mtundu woyera. The yogwira ndi metformin hydrochloride mu Mlingo wa 500, 850 mg ndi 1 g. Magnesium stearate ndi povidone ndizowonjezera zina. Zogwirizanitsidwa - macrogol 8000 ndi 400, opadra oyera.

Opanga INN

Dzina losavomerezeka la padziko lonse lapansi (INN) la mankhwalawa ndi metformin. Wopanga wamkuluyo ndi kampani yaku France ya zamankhwala Merck Sante. Palinso mndandanda wazomwe zimafananizidwa ndi mankhwala mosakanikirana, mankhwala omwe amagwiritsidwa ntchito omwe ndi metformin: Bagomet (Argentina), Avandamet (Spain), Bagomet plus (Argentina), Amaril M (Republic of Korea). Makampani opanga mankhwala ku Russia amapanganso zinthu zomwezi. Awa ndi Metglib, Glimecomb, Metformin Richter, Glformin Pronge ndi Glformin.

Mtengo wa ma CD a mankhwala oyamba ku Russia zimatengera muyeso wa zomwe zimagwira komanso kuchuluka kwa mapiritsi. Phukusi limodzi la 1000 mg (ma 30 ma PC.) Nthawi zambiri amagulitsidwa ma ruble 350., 60 ma PC. - 680 rub. Magawo 30 a 850 mg amawerengeka ndi ma ruble 320. Phukusi limodzi la 500 mg pa ma PC 30. mtengo pafupifupi ma ruble 270., ma ruble 60 - 420. Mtengo wa mankhwala umatha kusiyanasiyana malinga ndi dera, komanso mfundo zamitengo ya bungwe lamankhwala.

Pharmacokinetics

The yogwira thunthu limalowa kwathunthu ku lumen kwa m'mimba thirakiti. Mukamadya ndi chakudya, njirayi imachepetsa. The bioavailability wa mankhwala pafupifupi 60%. Kuzindikira kwakukulu kumawonedwa pambuyo maola 2,5

Chomwe chimapangika pakanthawi kochepa chimagawidwa mthupi lonse ndipo sichikugwirizana ndi mapuloteni am'madzi a plasma. Glucophage metabolism imadziwika makamaka mu minyewa ya impso. Hafu ya moyo ndi maola 6.5. Odwala omwe ali ndi vuto la impso, nthawi yayitali ya gawo lino imawonjezeka ndi 1.5-2 nthawi. Poterepa, chidwi cha kuphatikizika kwa zinthu zogwira ntchito mthupi nchotheka.

Chinsinsi chake ndi fomu yodalira insulin, yomwe imayendera ndi kunenepa kwambiri ndi kusachita masewera olimbitsa thupi komanso kudya moyenera. Monga mndandanda wopapatiza wowonetsa glucophage, izi ndizodziwika:

Monotherapy a shuga kwa odwala azaka zopitilira 10. Nthawi zina, angagwiritsidwe ntchito limodzi ndi insulin.
Chithandizo cha mitundu iwiri yamatenda a odwala akulu limodzi ndi insulin kapena othandizira ena a hypoglycemic. Nthawi zina, mankhwalawa amagwiritsidwa ntchito ngati monotherapy.

Glucophage tikulimbikitsidwa kupewa matenda a shuga 2.

Malangizo ogwiritsira ntchito (mlingo)

Zochizira matenda ashuga odwala akulu ngati gawo la mono - kapena mankhwala osakanikirana, mankhwalawa amagwiritsidwa ntchito molingana ndi malingaliro otsatirawa:

Mlingo woyambirira (850, 500 mg) ndi katatu patsiku, nthawi yakudya kapena itatha.
Kusintha kumachitika sabata iliyonse 2 kutengera zotsatira zamagazi. Kuwonjezeka mwadongosolo kwa mankhwalawa kumachepetsa chiopsezo chamtundu wamatumbo,
Mulingo wokwanira wokonza ndi 1,500-22,000 mg patsiku. Kuti muchepetse zovuta zosagwiritsidwa ntchito pazakudya zam'mimba, chiwerengerochi chimagawidwa mu Mlingo wa 2-3. Mlingo wololedwa tsiku lililonse wosaposa 3000 mg,
odwala omwe akukakamizidwa kutenga 3000 mg patsiku ayenera kusamutsidwa kupita ku metformin pa mlingo wa 1000 mg,
kuti mupeze mawonekedwe achire kwambiri pazamankhwala amtundu wodalira insulin, kuphatikiza kwa mahomoni awa ndi Glucofage kumagwiritsidwa ntchito. Mlingo woyambirira ndi 850 kapena 500 mg katatu patsiku. Pankhaniyi, kuchuluka kwa insulin kumasankhidwa payekha.

Mu ana azaka 10 ndi kupitilira, umagwiritsidwa ntchito ngati gawo la kuphatikiza kapena monotherapy. Kwa odwala ocheperako, mlingo woyambirira ndi 850 kapena 500 mg kamodzi tsiku lililonse. Chuma tsiku lililonse chothandizira ana ndi 2000 mg. Imagawidwa m'njira zingapo.

Anthu omwe ali ndi prediabetes amawonetsedwa Mlingo wa tsiku lililonse wa 1000 mpaka 1700 mg, omwe amalimbikitsidwa kuti agawidwe pawiri komanso pakudya. Kwa odwala omwe amadziwika kuti amalephera kupezeka bwino aimpso, Glucophage imayikidwa pokhapokha ngati palibe chiopsezo cha lactic acidosis. Mlingo watsiku ndi tsiku mu nkhani iyi ndi 1 g (1000 mg). Pa chithandizo, ndikofunikira kuwunika ntchito ya aimpso pafupipafupi. Ndi kuchepa kwa chilolezo cha creatinine mpaka 45 ml / mphindi ndi pansi, kuyang'anira Glucofage ndi koletsedwa.

Kwa okalamba, mlingo umasankhidwa payekha kutengera zofunikira za impso.

Bongo

Kutsika kwa kuchuluka kwa shuga m'magazi sikunawonedwe ngakhale pakuwonjezeka kwa chizolowezi cha tsiku ndi tsiku ka mankhwala a 42. Ngakhale izi, odwala omwe amapitilira pazovomerezeka zovomerezeka amawonjezera ngozi ya lactic acidosis. Ndi kukula kwa izi, ndikulimbikitsidwa kuti musiye kugwiritsa ntchito metformin nthawi yomweyo. Odwala otere amafunikira chithandizo chamankhwala chotsatira, motsimikiza mtima kwa lactate m'magazi. Chithandizo chothandiza kwambiri cha lactic acidosis ndi hemodialysis.

Kuyanjana kwa mankhwala osokoneza bongo

Madokotala amalimbikitsa kukhala tcheru pogwiritsa ntchito mankhwalawa limodzi ndi magulu otsatirawa:

Zodzikongoletsera. Zitha kutsogolera kukula kwa aimpso ndi lactic acidosis.
Glucocorticosteroids. Kuchepa kwa ketosis.
Entonable beta-2-adrenergic agonists. Amatha kuwonjezera kuchuluka kwa shuga m'magazi am'magazi.

Sitikulimbikitsidwa kuphatikiza kugwiritsa ntchito Glucofage ndi mowa wa ethyl. Kusakaniza kotereku sikungangobweretsa poizoni wambiri, komanso kuthekera kwakukulu kwa kukula kwa lactic acidosis. Kugwiritsa ntchito nthawi imodzimodzi ya metformin ndi iodine yochokera ku radiopaque ndizoletsedwa. Pankhaniyi, chiopsezo cha lactic acidosis chikuwonjezeka.

Kuyenderana ndi mowa

Pogwiritsa ntchito mfundo ya mankhwalawa, titha kunena kuti kugwiritsa ntchito kwake zakumwa zakumwa za ethanol kungayambitse kukula kwa kuledzera kwambiri ndi lactic acidosis. Izi ndizowona makamaka kwa odwala omwe ali ndi vuto la chiwopsezo cha hepatic, komanso omwe amakakamizidwa kutsatira zakudya zamafuta ochepa. Munthawi yamankhwala ndimakonzekera a metformin, ndikofunikira kupewa kumwa ngakhale pang'ono Mlingo wa mowa, komanso mankhwala a ethanol. Ngati atengedwa nthawi yomweyo, munthu amafunika chithandizo chamankhwala mwadzidzidzi.

Malangizo apadera

Musanayambe chithandizo cha matenda ashuga mu achinyamata ndi ana, ndikofunikira kuonetsetsa kuti dokotala akuwazindikira. Panthawi ya mayeso azachipatala, zidatsimikiziridwa kuti kugwiritsa ntchito glucophage sikukhudza kuchuluka kwa kutha msanga komanso kukula kwa thupi lonse. Odwala omwe ali ndi vuto la mtima, ndikulimbikitsidwa kuwunikira mosalekeza zochita za mtima munthawi ya mankhwala ndi metformin. Kuphatikiza apo, tikulimbikitsidwa kuti kuvomerezedwa kwa creatinine kusanthule musanayambe mankhwala ndi mankhwala. Ngati munthu wakonzekera kuchitapo kanthu opaleshoni, ndiye kuti kulandira kwa Glucophage kumayimitsidwa masiku awiri opaleshoni isanachitike.

Gwiritsani ntchito paubwana

Kugwiritsa ntchito glucophage pochiza matenda a shuga ndikovomerezeka kuyambira wazaka 10 zokha. Mwa odwala, mankhwalawa amagwiritsidwa ntchito onse limodzi ndi mankhwala a insulin komanso palokha. Chofunikira pakuthandizira kwa ana ndikutsatira mosamalitsa. Ngati mwana ali ndi zosiyana zotsutsana, ndiye kuti insulin yokha ndiyoyikidwa. Mlingo woyamba wa mankhwalawa kwa odwala omwe ali ndi zaka zopitilira 10 ndi 850 kapena 500 mg. M'tsogolomu, imachulukitsidwa mpaka 2000 mg, imadyedwa kangapo patsiku.

Kulandila mu ukalamba

Kugwiritsa ntchito mankhwalawa mankhwalawa mtundu wa matenda ashuga a 2 odwala omwe ali ndi zaka zopitilira 60 ndi osafunika kwambiri. Kuchepetsa kotereku kumagwirizanitsidwa ndi chiopsezo chachikulu chokhala ndi kulephera kwa impso mwa odwala. Ngati ndizosatheka kukana mankhwala, mlingo wake umalimbikitsidwa kuti uzisankhidwa payekha. Kuphatikiza apo, anthu okalamba amawunikidwa pafupipafupi kuti asankhe ma serum creatinine (osachepera katatu pachaka). Ndi kuchepa kwa chizindikiro ichi, chithandizo ndi Glucofage chimathetsedwa nthawi yomweyo.

Migwirizano ndi magwiritsidwe akusungidwa

Ndikulimbikitsidwa kuti muzikhala pamalo amdima pa kutentha osaposa + 25º C, kupatula ana kuti asamapezeke. Alumali moyo mapiritsi mu Mlingo wa 1000 mg zosaposa zaka zitatu, 850 ndi 500 mg - zaka 5. Ndi zoletsedwa kugwiritsa ntchito mankhwalawa pakapita nthawi yotsimikizika. Izi zimatha kuyipa mthupi ndipo zimayambitsa zovuta zingapo, mpaka pamikhalidwe yadzidzidzi.

Yerekezerani ndi mankhwala ofanana

Makampani opanga mankhwala amapanga mitundu yambiri ya mawonekedwe a Glucophage, omwe samangokhala ndi zithandizo zofanana, komanso ali ndi zosiyana zingapo. Mndandanda wa wotchuka kwambiri umaphatikizapo:

Siofor. Metformin mu mlingo wa 500 mg. Zolemba zowonjezera pazinthu zothandizira zimadziwika. Chovuta china ndi nthawi yochepa yochizira (pafupifupi theka la ola). Ngati tikufanizira Glucophage ndi Siofor, tikulimbikitsidwa kuti chisankhochi chizipangidwa mokomera oyambayo.
Metformin. The yogwira ndi metformin hydrochloride mu Mlingo wa 1000, 800 ndi 500 mg. Poyerekeza ndi zomwe zidapangidwa kale, zimakhala ndi zochulukirapo pazinthu zothandizira, zomwe ndizovuta kwambiri. Ubwino wake ndi wotsika mtengo.
Diabetes. Mosiyana ndi Glucofage, zimathandiza kuchepetsa kuchuluka kwa shuga m'magazi polimbikitsa kupanga insulin. Kugwiritsa ntchito kwake sikuti nthawi zonse kumakhala koyenera.
Reduxin. Kuphatikizikako kumakhala ndi zosakaniza monga sibutramine hydrochloride monohydrate ndi metformin mu mlingo wa 850 mg. Ndikofunika kuti mutenge matenda amtundu wa 2 shuga limodzi ndi onenepa kwambiri. Odwala omwe ali ndi kulemera kwabwino amalimbikitsidwa kuti azikonda Glucofage.
Maninil. Imakhala ndi mphamvu yokhudza ma β-cell a kapamba, ndikupangitsa kuti insulin ipite patsogolo. Kugwiritsa ntchito kwake kungalimbikitsidwe ngati simungathe kutenga glucophage.
Glucovans. Mu kapangidwe kake, glibenclamide imaphatikizidwa ndi metformin. Pankhani ya chitetezo ndi kugwira ntchito bwino, mankhwalawa onse ali pamodzimodzi.
Fomu. Kusiyana pakati pa mankhwalawo ndi koyambirira ndikupezeka kwa sodium mu kapangidwe ka croscarmellose, komwe kumawonjezera ngozi yodwala.
Glformin. Mfundo yochizira idakhazikitsidwa ndikuthandizira kulolerana kwa minofu yamoyo pazotsatira za insulin. Ili ndi mtengo wokwera komanso pafupipafupi kugwiritsa ntchito. Itha kuchita ngati njira ina yothandizira glucophage.
Glibomet. Muli glibenclamide ndi metformin mu mlingo wa 400 mg. Zimakhudza kuchuluka kwa kupanga kwa insulin mthupi, chifukwa chake igwiritseni ntchito mosamala. Ngati mulingo wothandizira simuwonetsedwa, kuyambika kwa hypoglycemia ndikotheka.
Galvus. Chofunikira kwambiri ndi vildagliptin (50 mg). Itha kugwiritsidwa ntchito ngati monotherapy komanso kuphatikiza ndi metformin.
Glucobay. Poyerekeza ndi Glucofage, sikuti imangosiyanitsidwa ndi mtengo wake wapamwamba (pafupifupi ma ruble 800 pamaphukusi), komanso ndi mphamvu yothandizira.
Gluconil. Ili ndi njira yofananira yogwirira ntchito, imakhudza chikhalidwe cha lipid metabolism ndikuwongolera mawonekedwe a fibrinolytic a magazi. Itha kugwiritsidwa ntchito ngati analogue ya metformin.

85% ya anthu omwe amatenga glucophage pochizira komanso kupewa mtundu wa matenda a shuga 2 amawona mphamvu zake zowonjezera, zomwe zimafotokozedwa kuchepa kwamphamvu kwa shuga m'magazi.Komabe, sizikhudza maselo a beta a kapamba ndipo sathandizira kapangidwe ka insulin. Lingaliro lofananalo limagawidwa ndi akatswiri azachipatala omwe ali ndi gawo la endocrinology, omwe amalimbikitsa Glucophage kwa odwala ambiri ngati gawo la mankhwala a mono- ndi mankhwala.

Ngati zithandizo zina za matenda ashuga sizinakuthandizeni, mutha kuthana ndi matendawa mu njira imodzi yokha limodzi ndi Dialux (Dialux).

Njira yachilengedwe ngati iyi imatsika, yomwe imabwezeretsa shuga, imayambitsa kukhathamiritsa kwa insulini "yanu" ndi maselo, imathandizira kugwira ntchito kwa ziwalo zamkati ndikuchotsa zoopsa m'thupi. Zambiri Zogulitsa →

Pochizira mafupa, owerenga athu adagwiritsa ntchito DiabeNot bwino. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Kusokonezeka kwa kapamba kumabweretsa kupanga insulin yokwanira ndipo kumathandizira kuti pakhale mtundu wa shuga wachiwiri. Matenda amtunduwu amatha kupezeka mosavuta kwa anthu azaka zopitilira 35- 40, akuvutika kwambiri ndi kulemera komanso anthu omwe ali ndi chiwonetsero cha matenda ashuga m'mabanja.

Kukhalabe ndi shuga yokhazikika yochepetsera magazi kumachepetsa chiopsezo chokhala ndi matenda okhudzana ndi matenda a shuga omwe angathe kupewedwa mwachangu pogwiritsa ntchito mankhwala osokoneza bongo a Russia Dialek. Werengani zambiri →

Matenda a shuga ndi matenda oopsa a dongosolo la endocrine la anthu, omwe amafunikira chisamaliro chokwanira ndi kuwunika kwa wodwalayo.

Pofuna kuthana ndi matenda a shuga, mazana ambiri a mankhwalawa amagwiritsidwa ntchito, omwe DIANOT amagawidwa, omwe zochita zawo zimakhazikitsidwa ndikugwiritsa ntchito zolandirira zachilengedwe. Kufotokozera kwamapangidwewa →

Matenda a shuga a SugaNorm ndi mankhwala apadera m'mbiri ya sayansi ya zamankhwala. Ili ndi mawonekedwe achilengedwe, mchitidwe womwe umakhazikitsidwa kuti ubwezeretse mulingo wazinthu ndikuchotsa mawonekedwe osokoneza bongo mwa odwala matenda ashuga.

Mankhwalawa amatha kuthana ndi matendawa, omwe amapewa zovuta komanso kukhazikika kwa mkhalidwe wa wodwalayo. Zambiri →

Matenda a shuga amatenga malo achitatu pamatenda ambiri omwe amafa chifukwa cha matenda a khansa ndi mtima.

Odwala matenda ashuga amakakamizidwa kuwunika momwe alili tsiku ndi tsiku, kutsatira chithandizo chamankhwala ndikugwiritsira ntchito mankhwala ovuta kuchokera ku mankhwala achikhalidwe komanso omwe si achikhalidwe. Zambiri Zogulitsa →

Ji Dao Chinese Diabetes Adhesive ndi njira ina yochiritsira matenda osachiritsika. Kuchita khungu pakapangidwe kamagazi ndi ntchito ya ziwalo ndi machitidwe a thupi, pang'onopang'ono imabwezeretsa njira za metabolic. Zambiri →

Kuchiza ndi kuchepa thupi kwa anthu odwala matenda a shuga mothandizidwa ndi mankhwalawa Siofor 500

Siofor - mankhwala okhudzana ndi mapiritsi antidiabetesic piritsi. Zomwe zimagwiritsidwa ntchito ndi mankhwala ndi metformin. The siofor imapangidwa ndi kampani ya Berlin-Chemie, yomwe ndi gawo lalikulu la bungwe lachipatala la ku Italy lotchedwa Menarini Group.

Kupanga mankhwalawa pansi pa dzina la malonda la Siofor kumachitika ku Germany ndi Eastern Europe. Mankhwalawa amapangidwa motsatira mosamalitsa ndi miyezo ya GMP, kotero mtundu wa mankhwalawo nthawi zonse umakhalabe wambiri. Mu Russian Federation, imapezeka mu mankhwalawa - 500 mg, 850 mg, 1000 mg.

Njira yamachitidwe

Siofor ndi nthumwi ya kalasi yayikulu. Mankhwalawa amachepetsa shuga wamagazi pokhapokha kudya, komanso shuga yofunikira. Metformin siyimapangitsa maselo a kancreatic beta kuti apange kwambiri insulin, zomwe zikutanthauza kuti sizitsogolera ku hypoglycemia. Mankhwalawa amachotsa hyperinsulinemia, yomwe mu shuga ndimomwe imayambitsa kulemera ndikukula kwa zovuta zamtima.

Njira yochepetsera shuga mukamagwiritsa ntchito kukonzekera kwa Siofor ndikuwonjezera mphamvu ya maselo a minofu kutenga glucose kuchokera m'magazi, komanso kuwonjezera chidwi cha insulin receptors pamitsempha yama cell.

Mankhwala osokoneza bongo a Siofor amachepetsa kuchepa kwa chakudya cham'mimba ndi chakudya cham'mimba, kuthamangitsa makutidwe a oxidation aulere mafuta acids, ndikuyambitsa anaerobic glycolysis. Mankhwalawa a matenda ashuga komanso kunenepa kwambiri amachepetsa njala, zomwe zimapangitsa kuti munthu achepetse thupi. Mwa anthu omwe alibe matenda ashuga, mapiritsi awa samachepetsa shuga komanso alibe zinthu zonsezi.

Anthu odwala matenda ashuga omwe amamwa mankhwalawa ndikutsatira zakudya zapadera, ndipo nthawi zina amachepetsa thupi. Izi zimapanga maziko owunika kuti metformin ndi njira yochepetsera kunenepa. Koma sizili choncho nthawi zonse.

Kupatula apo, kuchepetsa kulemera kwa matenda ashuga ndicholinga cha onse odwala matenda ashuga komanso adokotala. Ngati siofor atachepera thupi, ndiye kuti amapatsidwa odwala onse omwe ali ndi matenda ashuga, ndipo amayamba kuwonda ndi ma rhinestones. Koma, mwatsoka, odwala matenda ashuga amatenga Siofor kwa zaka zingapo mosiyanasiyana kuchokera ku 500 mg kapena 850 mg patsiku mpaka kuchuluka kwa 1000 mg katatu pa tsiku samazindikira kwambiri kuwonda.

Sankhani

Patsamba lamankhwala, mungapeze mitundu itatu yokha ya mankhwalawa - mapiritsi a 500 mg, 850 mg ndi 1000 mg. Mlingo wa mankhwalawa ukhoza kusankhidwa ndi dokotala okha. Nthawi zambiri, metformin imayamba ndi yaying'ono kwambiri - 500 mg. Pa kumwa kwa mankhwalawa amasiya ngati munthuyo ali ndi matenda osokoneza bongo. Siofor 500 imalandilidwanso ndi anthu omwe akufuna kuchepetsa thupi.

Ngati sabata litatha kumwa manformin 500 odwala matenda ashuga alibe zotsatira zoyipa, ndiye kuti mankhwalawa amachulukitsidwa ndikusamutsidwa kwa Siofor 850, kapena piritsi lina la 500 mg limawonjezeredwa maola 12 mutatha kumwa piritsi loyambalo 500 mg la mankhwalawa. Masiku 7 aliwonse, 500 mg ya metformin imawonjezeredwa pang'onopang'ono ku mlingo wololedwa komanso wothandiza.

Ndi kuchuluka kwa mankhwalawa, zotsatira zoyipa zimatha kuchitika, zomwe zimafuna kuchepetsa mlingo wa kuchuluka kwa woyamba. Popita nthawi, muyeneranso kuyesetsa kuwonjezera mlingo kuti ukhale wogwira ntchito bwino.

Mapiritsi a Siofor amaphwanyidwa popanda kutafuna ndikutsukidwa ndimadzi oyera ambiri. Ndikwabwino kuchita izi mukatha kudya kapena nthawi yomweyo mukamadya. Ngati mankhwalawa adapangidwira kuchuluka kwa 500 mg, amatengedwa kamodzi, madzulo - izi zimachepetsa chiopsezo cha mavuto. Ngati 1000 mg patsiku limayikidwa, ndiye kuti mankhwalawa amayenera kugawidwa mu 2 Mlingo wa 500 mg aliyense, pambuyo maola 12, m'mawa ndi madzulo.

Dokotala amatha kukupatsani mankhwala okwanira 1000 mg katatu patsiku, koma, monga ulamuliro, 1000 mg kawiri pa tsiku ndizokwanira pa chithandizo chamankhwala a shuga komanso kuwonda. Ndikofunikira kwambiri kuti munthawi yamankhwala omwe mumapatsidwa mankhwala osokoneza bongo a Siofor, nthawi zambiri mumatenga mayesero ena omwe amawonetsa ntchito ya impso ndi chiwindi. Ndiye kuti, kuyezetsa magazi kambiri, kuyezetsa magazi a biochemical (creatinine, michere ya chiwindi).

Pomwe osatenga

Ngati, ngakhale mudali ndi machenjezo ndi malingaliro onse, mudasankha kuti muchepetse thupi ndi mankhwalawa. Kumbukirani kuti muyenera kuwerengera mosamala ndikusunga malangizo omwe wopanga amapanga m'bokosi lililonse la mankhwalawa.

Kumbukirani! Munthu amene akumwa Siofor, ngakhale osachepera 500 mg, ayenera kusiya mowa. Kuphatikizika kwa mankhwalawa komanso mowa kumabweretsa chiwonongeko chosasinthika cha chiwindi.

Siofor imaphatikizidwanso ngati muli:

mtundu 1 shuga
kusowa kwamadzi
vuto la impso kapena chiwindi,
Mimba, kuyamwa,
Sars, fuluwenza, bronchitis, chibayo ndi matenda ena opatsirana, kapena matenda am'mapapo,
kutentha kwambiri kwa thupi
Opaleshoni akubwera kapena mwavulala,
kusokonezeka kwa mtima dongosolo, myocardial infaration,
zotupa
uchidakwa wambiri,
matenda a shuga kapena chikomokere,
ketoacidosis.

Mapiritsi awa sanalembedwe kwa ana ndipo amachepetsa kugwiritsa ntchito mwa anthu opitirira zaka 60. Metformin sayenera kumwedwa ngati mukuchita nawo masewera olimbitsa thupi kapena kugwira ntchito molimbika. Kupanda kutero, izi zidzatsogolera pakupanga zotsatira zoyipa zotchulidwa.

Kuchepetsa ndi kuwunika

Malangizowo kwa Siofor okhudza kugwiritsa ntchito mapiritsi a zakudya awa sanena chilichonse. Kudzipangira nokha mankhwala osokoneza bongo sikulinso koyenera. Ndikofunikira kufunsa dokotala ndikumufunsa za momwe angapangire mankhwalawa kuti muchepetse kunenepa. Mwina adotolo, potengera zomwe adakumana nazo, kuwunika kwa odwala ndi zotsatira za mayeso anu, angakulimbikitseni mankhwalawa kuti muchepetse kulemera kwamankhwala osachepera 500 osaposa miyezi itatu.

Ndemanga yakuchepetsa thupi ndi siofor imatsimikizira kuti okhawo omwe amatsatira zakudya zochepa zopatsa mphamvu ndikuchepetsa kuchuluka kwa chakudya chamagulu am'mimba zomwe zimapangitsa kuti achepetse thupi.

Maganizo olakwika wamba

Nthano yoyamba. Amathandizira kuchepa thupi mwakufuna

Ndemanga za kuchepetsa thupi zimatsutsana ndi nkhaniyi. Kuti muchepetse kunenepa, kudya komwe kumaletsedwera zotsekemera, ufa, mafuta ndi yokazinga ndikofunikira. Siofor imodzi yokhala ndi mapaundi owonjezera sangathe kupirira.

Nthano 2. Zimaletsa kulakalaka maswiti

Siofor siyimakhudza zizolowezi zowonda ndi zokonda za munthu. Kutchuka kwa mankhwalawa chifukwa cha kuchepa thupi kukutsika chifukwa cha kuchuluka kwakanema kosakhutira.

Nthano 3. Mankhwala osavulaza

Ndemanga za asayansi zikunena kuti siofor imakhudzanso kagayidwe ka munthu wathanzi. Chifukwa cha kuchuluka kwa zotsatira zoyipa mukamamwa mankhwalawa. madokotala ochulukirachulukira ali ndi mwayi wopanga mankhwalawa pamndandanda wokalandira mankhwala.

Ngati mutha kuchepetsa thupi ndi metformin pokhapokha mutatsata zakudya zowonjezera, ndiye bwanji kudzipatula kwambiri ndikuyika pachiwopsezo cha zotsatira zoyipa za mankhwalawa? Tsoka ilo, Siofor, monga mapiritsi ena odya, sakanakhoza kukhala mankhwala ozizwitsa omwe amachotsa mapaundi owonjezera mosavuta.

Kuchita ndi mankhwala ena

Zoletsa za hypoglycemic zotsatira za mankhwalawa ndi angiotensin kutembenuza ma enzyme inhibitors (Captopril, enalapril), H2-histamine receptor blockers (cimetidine), mankhwala antifungal (miconazole, fluconazole), mankhwala omwe si a antiidal anti-inflammatory (NSAIDs), phenylbenzofenbazon ), anti-tuberculosis (ethionamide), salicylates, coumarin anticoagulants, anabolic steroids, beta-blockers, monoamine oxidase inhibitors, sulfonamides Zochita zinthu denga, cyclophosphamide, biguanides, chloramphenicol, fenfluramine, acarbose, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular katulutsidwe blockers, reserpine, bromocriptine, disopyramide, pyridoxine, insulin, allopurinol.
Barbiturates, glucocorticosteroids, adrenostimulants (epinephrine, clonidine), antiepileptic mankhwala (phenytoin), BMCC, carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, furosemide, triazinazide azamizaneamene azeneidene azaneazeneidane azaneidene azamazaneamene azaneazeneamane azaneazeneazamazaneamane azaneazeneazaneamane azaneazeneamane azaneazeneamane azaneazeneamane azaneazeneazamazaneamane azaneazeneamane azaneazeneamane azaneazeneazamazaneamane. salbutamol, terbutaline, glucagon, rifampicin, mahomoni a chithokomiro, mchere wa lithiamu, milingo yayikulu ya nicotinic acid, chlorpromazine, kulera kwapakamwa komanso estrogens.
Mankhwala a urine acidifying (ammonium chloride, calcium chloride, ascorbic acid mumadontho akuluakulu) amalimbikitsa zotsatira zake pochepetsa kusiyana kwake ndikuwonjezera kubwezeretsanso kwa glibenclamide.
Ethanol imawonjezera mwayi wokhala ndi lactic acidosis.
Furosemide imachulukitsa ndende yambiri m'magazi (Cmax) ya metformin ndi 22%.
Nifedipine imawonjezera mayamwidwe, Cmax, imachepetsa kuchotsedwa kwa metformin. Mankhwala a Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren ndi vancomycin) omwe amatulutsidwa mu mphukira zomwe zimapikisananso machitidwe ogwiritsira ntchito ma tubular ndipo, ndi chithandizo chambiri, amatha kuonjezera Cmax ya metformin ndi 60%.
Metformin imachepetsa Cmax ndi T½ ya furosemide ndi 31 ndi 42.3%, motsatana.