Invokana 100 > Chithandizo ndi kupewa

Pali mankhwala omwe ali ndi shuga omwe samangothandiza shuga wamagazi ochepa, komanso kupewa kunenepa kwambiri ngati matenda opezeka pafupipafupi. Chimodzi mwazida zotere, mogwirizana ndi malangizo ogwiritsira ntchito, ndi Attokana. Mankhwalawa ali ndi mtengo wokwera kuyerekeza ndi anzawo, koma akatswiri ndi odwala amawona kugwira kwake ntchito.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Amapezeka mu mapiritsi okhala ndi mawonekedwe a kapisozi okhala ndi zokutira kwamafilimu achikasu kapena oyera. Pa odulidwa - oyera. Pali mitundu iwiri ya Mlingo: 100 ndi 300 mg yogwira ntchito.

102 kapena 306 mg wa canagliflozin hemihydrate (ofanana ndi 100 kapena 300 mg wa canagliflozin),
MCC - 39.26 kapena 117.78 mg,
lactose wam'madzi - 39.26 kapena 117.78 mg,
croscarmellose sodium -12 kapena 36 mg,
Hyprolose - 6 kapena 18 mg,
magnesium stearate -1.48 kapena 4.44 mg.

Atanyamula makatoni ma CD 1, 3, 9 kapena 10 matuza 10 mapiritsi.

Opanga INN

Dzinalo lapadziko lonse lapansi ndi canagliflozin.

Wopanga - Janssen-Ortho, Puerto Rico, yemwe ali ndi satifiketi yamalonda - Johnson ndi Johnson, USA. Pali ofesi yoimilira ku Russia.

Mtengo wa mapiritsi 30 a 100 mg a canagliflozin amayamba kuchokera ku 2500 rubles. Mankhwala omwe ali ndi mphamvu yambiri yogwira ntchito amawononga 4 rubles.

Zotsatira za pharmacological

Hypoglycemic wothandizira. Mwa katundu, ndimalepheretsa shuga wodutsa glucose wa mtundu wachiwiri. Kuchulukitsa katulutsidwe wa timadzi ndi impso, zomwe zimapangitsa kutsika kwake kuzungulira m'magazi. Mphamvu ya diuretic yomwe imachitika pamenepa imathandizira kuchepetsa kupanikizika ndikupangitsa kuti muchepetse thupi, zomwe ndizofunikira kwambiri kwa matenda ashuga a 2. Chiwopsezo cha hypoglycemia pochiza "Invokoy" ndichochepa, izi zimatsimikiziridwa ndi maphunziro. Kuphatikiza apo, insulin katulutsidwe ndi maselo a pancreatic beta amakhala bwino.

Pharmacokinetics

Kuzindikira kwakukulu kumatheka pambuyo pa maola 1-2. Kutha kwa theka-moyo kumachokera ku maola 10 mpaka 13. The bioavailability wa mankhwalawa 65%. Amathandizidwa ndi impso mu mawonekedwe a metabolites apadera, komanso kudzera m'mimba.

Type 2 shuga mellitus mwa akulu, onse monga monotherapy komanso osakaniza ndi hypoglycemic mankhwala (kuphatikizapo insulin).

Malangizo ogwiritsira ntchito (njira ndi Mlingo)

Kuchiza nthawi zonse kumayamba ndi mapiritsi ochepera. Gwiritsani ntchito kamodzi patsiku musanadye chakudya choyambirira. Mlingo wa 100 kapena 300 mg, kutengera zosowa za thupi.

Kuphatikiza ndi insulin ndi zotumphukira za sulfonylurea, mlingo wa mankhwalawa ungathe kuchepetsedwa.

Ngati mukuphonya nthawi yokumana, kumwa mapiritsi awiri nthawi imodzi ndikuloledwa.

Anthu opitilira zaka 60 ndipo anthu omwe ali ndi vuto la impso amayenera kugwiritsa ntchito mankhwalawa mosamala komanso moyang'aniridwa ndi dokotala.

Zotsatira zoyipa

Kudzimbidwa
W ludzu, pakamwa lowuma
Polyuria
Matenda amitsempha
Urosepsis
Pollakiuria
Balanitis ndi balanoposthitis,
Vaginal, matenda a fungus,
Kutumiza,
Kawirikawiri, matenda ashuga ketoacidosis, hypoglycemia, edema, chifuwa, kulephera kwa impso.

Malangizo apadera

Zotsatira za "Encokany" pa thupi la odwala matenda ashuga 1 sizinaphunziridwe, chifukwa chake, kuvomerezedwa nkoletsedwa.

Gwiritsani ntchito mosamala odwala omwe ali ndi hematocrit okwera.

Ngati pali mbiri ya ketoacidosis, itengereni moyang'aniridwa ndi achipatala. Pankhani ya chitukuko cha matenda a zamatenda, kugonekedwa kuchipatala kumafunikira. Pambuyo kukhazikika kwa boma la thanzi, chithandizo chitha kupitilizidwa, koma ndi mlingo watsopano.

Sizipangitsa kukulitsa zotupa zopweteka.

Kulandiridwa ndi insulin ndi mankhwala omwe amapanga kupanga kwake kumawonjezera mwayi wokhala ndi hypoglycemia.

Ndi kupsinjika kocheperako, makamaka kwa achikulire opitilira 65, mugwiritse ntchito mosamala.

Mankhwala pawokha sangakhudze kuyendetsa bwino. Komabe, limodzi ndi mankhwala, wodwalayo ayenera kuchenjezedwa za chiwopsezo cha hypoglycemia. Funso la kufunika koyendetsa galimoto limasankhidwa ndi adokotala.

MTHANDIZO. Mankhwalawa amapezeka kokha pamankhwala omwe mumalandira!

Fananizani ndi fanizo

Chida ichi chili ndi ma analogi angapo, zomwe zingakhale zofunikanso kuziyerekeza poyerekeza katundu.

Forsiga (dapagliflozin). Amalepheretsa mayamwidwe a shuga, amachepetsa chilimbikitso. Mtengo - kuchokera ku 1800 rubles. Wopangidwa ndi Bristol Myers, Puerto Rico. Mwa mphindi - zoletsa kuvomerezedwa kwa okalamba, ana ndi amayi apakati.

"Baeta" (exenatide). Imachepetsa kutsuka kwam'mimba, zomwe zimapangitsa kuti muchepetse thupi. Mlingo wa glucose umakhazikika. Mtengo umafika ku ruble 10,000. Wopanga - Eli Lilly & Company, USA. Chombochi chimatulutsidwa m'miyala ya syringe, yomwe ndi yabwino kwa jakisoni wodziimira. Mndandanda waukulu wa contraindication ndi zotsatira zoyipa.

Victoza (liraglutide). Zimathandizira kuchepetsa kulemera ndikuyambitsa kukhazikika kwa glucose. Amapanga kampani yaku Danish Novo Nordisk. Mtengo wake ndi pafupifupi ma ruble 9000. Amapezeka m'mapensulo a syringe. Amawerengera onse matenda a shuga komanso kunenepa kwambiri komwe kumayenderana nawo.

NovoNorm (repaglinide). Hypoglycemic. Wopanga - "Novo Nordisk", Denmark. Mtengo wake umakhala wotsika kwambiri - kuchokera ku ma ruble a 180. Zimathandizanso kuti wodwala azikhala wathanzi. Mankhwalawa sioyenera aliyense, pali zambiri zotsutsana.

"Guarem" (garu chingamu). Amanenanso kunenepa kwambiri kwa odwala omwe ali ndi matenda ashuga a 2. Amachepetsa shuga. Gwiritsani ntchito ngati njira yothetsera pakamwa. Wopanga "Orion", Finland. Mtengo wake ndi pafupifupi ma ruble 550 pachikwama chilichonse cha granules. Choyipa chachikulu ndizotsatira zoyipa, kuphatikizaponso m'mimba. Koma ichi ndi mankhwala othandiza kwambiri.

"Diagninid" (repaglinide). Amasankhidwa kuti azichulukitsa kuchuluka kwa shuga komanso kukhalabe ndi kulemera kwa wodwalayo. Mtengo wa phukusi la mapiritsi 30 ndi ma ruble 200. Chida chothandiza komanso chotsika mtengo, koma chili ndi zotsutsana zingapo. Chifukwa chake, sichimalamulidwa kwa amayi apakati, amayi oyamwitsa, okalamba ndi ana. Ndikofunikira kutsatira zakudya ndikuchita masewera olimbitsa thupi kuti mukwaniritse zonse.

Kusinthira ku mankhwala ena ndikotheka kokha ndi chilolezo cha dokotala. Kudzipatsa nokha koletsedwa!

Odwala amadziwa kuphweka kwa ntchito kamodzi patsiku, kukwera kwambiri komanso kusowa kwa hypoglycemia ngati vuto.

Tatiana: “Ndili ndi matenda ashuga. Ndidayesera zinthu zambiri kuti ndichiritsidwe, adotolo adandilangiza kuti ndiyese Attokana. Mankhwala abwino, osakhala ndi mavuto. Mtengo ndi wokwera, inde, koma kuyendetsa bwino ntchitoyo kumakwaniritsa chilichonse. Chifukwa chake ndikusangalala ndi kusinthaku. ”

George: “Dotolo adandiuza kuti ndiyesere mankhwala atsopano a Attokana. Anatinso amawunikira bwino. Zowonadi, shuga yatsika bwino komanso ndi zabwinobwino. Panali zoyipa mu mawonekedwe a zotupa, mulingo wa mankhwalawo unasinthidwa. Tsopano zonse zili mu dongosolo. Ndakhuta. "

Denis: “Posachedwa ndinasinthira ku Attokana. Njira yabwino yothetsera matenda ashuga, imapangitsa kuti shuga azichita bwino. Kwa ine, chinthu chachikulu ndikuti palibe hypoglycemia, makamaka popeza ndimangomwa mapiritsi awa, popanda insulin. Amamva bwino, zonse zimakwanira. Zokhazo zoyipa ndizokwera mtengo komanso kufunikira kwa dongosolo la mankhwala pasadakhale. Zotsalazo ndi mankhwala abwino kwambiri. ”

Galina: “Ndinayamba kumwa mankhwalawa, ndipo ndinali ndi nkhawa. Ndinapita kwa katswiri, kukalandira mankhwala, ndipo adotolo anasintha mlingo. Chilichonse chapita. Tsopano ndikupitiliza kuthandizidwa ndimankhwala awa. Wopambana kwambiri - msinkhu wa shuga wakhazikika, popanda kukayika. Chofunikira kwambiri musaiwale za kadyedwe. ”

Olesya: "Agogo anga aamuna adasankhidwa kuti" Invokan ". Poyamba ankalankhula bwino kwambiri za mankhwalawa, ankakonda chilichonse. Kenako anali ndi ketoacidosis, ndipo adotoyi adasiya. Tsopano thanzi la agogo ndilabwino, koma akuchiritsidwa ndi insulin. ”

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Invocana ndi mankhwala okhala ndi vuto la hypoglycemic. Chochita chake chimapangidwira pakamwa. Invokana imagwiritsidwa ntchito bwino ndi odwala omwe ali ndi matenda a shuga a mtundu II.

Mankhwalawa amakhala ndi moyo wa zaka ziwiri zamatali. Sungani mankhwalawo pamtunda osapitirira 30 0 C.

Wopanga mankhwalawa ndi Janssen-Ortho, kampani yomwe ili ku Puerto Rico. Kulongedza kumapangidwa ndi kampani ya Janssen-Silag yomwe ili ku Italy. Wogwirizira ufulu wa mankhwalawa ndi Johnson & Johnson.

Gawo lalikulu la mankhwalawa ndi Kanagliflosin hemihydrate. Piritsi limodzi la Invokana pali pafupifupi 306 mg yogwira ntchito.

Kuphatikiza apo, pakupanga mapiritsi a mankhwalawa, pali 18 mg ya hyprolysis ndi anactrous lactose (pafupifupi 117.78 mg). Mkati mwa piritsi mulinso magnesium stearate (4.44 mg), microcrystalline cellulose (117.78 mg) ndi croscarmellose sodium (pafupifupi 36 mg).

Chigoba cha malonda chimakhala ndi filimu, yomwe ili ndi:

macrogol
talcum ufa
mowa wa polyvinyl
titanium dioxide.

Attokana akupezeka mu mawonekedwe a mapiritsi a 100 ndi 300 mg. Pamapiritsi a 300 mg, chipolopolo chomwe chimakhala ndi mtundu woyera chimapezeka; pamapiritsi a 100 mg, chipolopolo chimakhala chikaso. Pamitundu yonse iwiri ya mapiritsi, mbali imodzi pali zolemba "CFZ", ndipo kumbuyo kuli manambala 100 kapena 300 kutengera kulemera kwa piritsi.

Mankhwalawa amapezeka mwa matuza. Chithuza chimodzi chimakhala ndi mapiritsi 10. Paketi imodzi imatha kukhala ndi matuza 1, 3, 9, 10.

Zizindikiro ndi contraindication

Mankhwalawa amalembedwa kwa odwala omwe ali ndi matenda a shuga a mtundu II.

Mankhwalawa angagwiritsidwe ntchito:

ngati njira yodziyimira payokha komanso yothandizira matenda,
kuphatikiza ndimankhwala ena ochepetsa shuga ndi insulin.

Pakati pazitsutso zomwe zingagwiritsidwe ntchito, otsatsira amawonekera:

kulephera kwambiri kwa aimpso,
tsankho lanu Kanagliflosin ndi zina mwa mankhwala,
lactose tsankho,
wazaka 18
kulephera kwambiri kwa chiwindi,
lembani matenda ashuga
Kulephera kwamtima kwanthawi (makalasi atatu ogwira ntchito),
yoyamwitsa
matenda ashuga ketoacidosis,
mimba

Hypoglycemic mankhwala Invokana - zotsatira za thupi, malangizo, ntchito

Attokana ndi dzina lamalonda lamankhwala lotengedwa kuti muchepetse shuga.

Chidacho chapangidwira odwala omwe ali ndi matenda a shuga a mtundu II. Mankhwalawa amagwira ntchito mothandizidwa ndi monotherapy, komanso limodzi ndi njira zina zochizira matenda ashuga.

Yeva adalemba 13 Jul, 2015: 215

Rais, ngati * mankhwala a Invokan hypoglycemic (kanagliflozin) atalandira kalata yolembetsedwera ku Russia *, zikutanthauza kuti anapambana mayesowo, koma a FDA anachenjeza za ngozi yotenga ketoacidosis mwa odwala omwe ali ndi matenda amtundu wa 2 omwe amamwa mankhwala obadwira a m'badwo watsopano - SGLT2 inhibitors. werengani chenjezo:
http://moidiabet.ru/news/amerikancev-predupredili-o-riske-oslojnenii-pri-prieme-rjada-lekarstv-ot-diabeta

Julia Novgorod analemba 13 Jul, 2015: 221

Za chiopsezo chotenga ketoacidosis.

Kutengera ndi lingaliro la momwe mankhwalawo agwirira ntchito, ndizomveka kuganiza kuti mankhwalawa ndi otetezeka pankhaniyi kwa odwala omwe ali ndi matenda a shuga a 2 omwe ali ndi vuto losamalidwa bwino la chimbudzi, kwa omwe chifukwa chachikulu cha hyperglycemia amakhala wosusuka kwambiri, ndipo ndiwowopsa pazochitika za pancreatic kale - kuti ngakhale machitidwe okhazikika azakudya sangathe kupereka shuga pansipa.

Ndipo milandu ya ketoacidosis yomwe idalembedwa panthawi ya kuyesedwa, mokulira, ikhoza kupewedwa ndi njira yolinganizira yopezeka ndi mankhwalawa, poganizira mfundo zomwe zachitika ndi zomwe odwala enieni - kapena anthu amasankhidwa mwadala kuti ayesedwe pamagawo osiyanasiyana a T2DM, kotero kuti pambuyo pake lembani zoyenera.

Irina Antyufeeva adalemba pa 14 Jul, 2015: 113

Kwa a Julia Novgorod

Julia, sangatchulidwe chifukwa cha SD-2 - kusasamala kwenikweni. Anthu odwala matenda ashuga amtundu wa 2 samasangalatsa kuposa mtundu wa anthu ashuga 1. Kungokhala kuti odwala ambiri omwe ali ndi matenda a shuga 2 amakhala ndi zochuluka kuposa zawo insulin, ndipo insulini ndi chimodzi mwazinthu zazikulu zopanga mafuta.

Tsopano za wonena. Zomwe ndidapeza pompano pa intaneti: amangochotsa shuga m'magazi ndi mkodzo. Zotsatira zake, munthu amalandira, choyambirira, matenda angapo a fungus mu perineum, ndipo chachiwiri, impso, zikugwira ntchito munjira iyi, zimalemala msanga. Iwo omwe adakhala ndi nthawi yoyesera evokvana amadandaula za kutenthedwa mtima pakukodza ndi mavuto a pakhungu. Ngakhale shuga m'magazi amachepetsa kwambiri.
Mwinanso likuyenera kugwiritsidwa ntchito ngati chadzidzidzi, mankhwala osakhalitsa munthawi zina pomwe zithandizo zina sizithandiza, koma osatha.
Ndipo chinthu chimodzi chinanso. Italy idakana kugwiritsa ntchito analogue ya mankhwalawa, chifukwa matenda a oncological adapezeka mwa m'modzi mwa omwe anali nawo pagulupo. Pambuyo pake, Johnson ndi Johnson adasintha dzina lake ndikupereka ku Russia.

Irina Antyufeeva adalemba pa 14 Jul, 2015: 212

Nayi zambiri kuchokera pa intaneti:

Zotsatira zakusaka ndi zokambirana. Kanagliflozin "osalakwa"Cholinga chake ndi kuwongolera kuchuluka kwa shuga m'magulu akuluakulu omwe ali ndi matenda ashuga a 2. "Attokana"- pulogalamu yoyamba ya protein yotchedwa sodium glucose inhibitor 2 (SGLT2), yovomerezedwa ndi izi. Kanagliflozin imalepheretsa kusunganso shuga kwa impso, ndikuchulukitsa kuphipha kwake, komwe kumachepetsa kuchuluka kwa shuga m'magazi. Chitetezo ndi Kuchita BwinoAttokana"Anaphunzira m'mayesero asanu ndi anayi othandizira odwala odzipereka 10,285 omwe ali ndi matenda a shuga a 2. Mankhwalawa adafufuzidwa onse ndikugwiritsa ntchito pawokha komanso kuphatikiza mankhwala ena omwe amagwiritsidwa ntchito pochiza matenda amitundu iwiri: metformin, sulfonylurea, pioglitazone ndi insulin.
Mankhwala sayenera kugwiritsidwa ntchito pochiza matenda amtundu wa 1 odwala odwala ketoacidosis komanso kuwonongeka kwaimpso.
Zotsatira zodziwika bwino "osalakwa"Panali matenda yisiti ndi matenda a kwamkodzo. Chifukwa chakuti mankhwalawa amayambitsa kukodzetsa, amatha kuchepetsa kuchuluka kwa magazi, kumayambitsa orthostatic kapena postural (dontho lakuthwa pamagazi akutsikira mukasunthira pamalo owongoka) hypotension. Izi zimatha kubweretsa zizindikiro monga chizungulire kapena kukomoka, ndipo zizindikirozi ndizofala kwambiri m'miyezi itatu yoyambirira ya mankhwala.
Mapeto Muthana "osalakwa"Cholinga chake ndikuwongolera kuchuluka kwa shuga m'magazi a akulu omwe ali ndi matenda amtundu wa 2, koma zovuta zomwe zimadziwika ndi mayesero azachipatala ziyenera kukumbukiridwa popereka mankhwala.

Odwala Apadera ndi Mayendedwe

Attokana amapangika mu amayi apakati komanso ana osakwana zaka 18. Mankhwalawa sayenera kumwedwa ndi akazi akumiyendo, popeza Kanagliflozin amalowa mkaka wa m'mawere ndipo amatha kuwononga thanzi la wakhanda.

Amagwiritsidwa ntchito mosamala ndi anthu opitirira zaka 75. Mankhwala ndi omwe amapereka mankhwala ochepera.

Iwo ali osavomerezeka kuti apereke mankhwala kwa odwala:

ndi impso yolimba,
ndi kulephera kwa aimpso mu gawo lomaliza,
ikuyimba.

Mankhwalawa amatengedwa mosamala kwa anthu omwe ali ndi vuto lochepa laimpso. Pankhaniyi, mankhwalawa amatengedwa muyezo wochepa - 100 mg kamodzi patsiku. Ndi kulephera kwakakhazikika kwa impso, mulingo wochepa wa mankhwalawo umaperekedwanso.

Ndi koletsedwa kumwa mankhwalawa odwala omwe ali ndi matenda a shuga 1 komanso matenda a shuga a ketoacidosis.Kufunika kwa achire chifukwa chomwa mankhwalawo pomaliza chifukwa cha matenda aimpso kulephera.

Attokana alibe machitidwe owononga thupi komanso osokoneza bongo m'thupi la wodwalayo. Palibe chidziwitso chokhudza mphamvu ya mankhwalawa pakubala kwa munthu.

Mankhwala ophatikizidwa pamodzi ndi mankhwala ndi othandizira ena a hypoglycemic, tikulimbikitsidwa kuti muchepetse mulingo wotsatira kuti mupewe hypoglycemia.

Popeza Kanagliflozin ali ndi diuretic yambiri, munthawi ya kayendetsedwe kake, kuchepa kwa kuchuluka kwa intravascular mwina. Odwala omwe ali ndi zizindikiro mu mawonekedwe a chizungulire, ochepa hypotension, ayenera kusintha mlingo wa mankhwalawo kapena kuthetseratu kwathunthu.

Kutsika kwa magazi kumitsekemera kumachitika kawirikawiri m'mwezi woyamba ndi theka kuyambira chiyambi cha mankhwala ndi Invocana.

Kuchotsa mankhwala kumachitika chifukwa cha zomwe zimachitika;

vulvovaginal candidiasis mwa akazi,
candida balanitis mwa amuna.

Kuposa 2% ya azimayi ndi 0.9% ya amuna anali ndi matenda obwerezabwereza akamamwa mankhwalawa. Milandu yambiri ya vulvovaginitis imawonekera mwa amayi mkati mwa masabata 16 oyamba kuchokera pomwe anayamba chithandizo ndi Invocana.

Pali umboni wazomwe zimapangitsa mankhwalawo kuphatikizika kwa mafupa mwa anthu omwe ali ndi matenda amtima. Mankhwalawa amatha kuchepetsa mphamvu yam'mafupa, zomwe zimapangitsa kuti akhale pachiwopsezo cha kuwonongeka pagulu la odwala. Mankhwala osamala amafunika.

Chifukwa cha chiwopsezo chachikulu chotenga hypoglycemia ndi chithandizo chophatikizira cha Invokana ndi insulin, tikulimbikitsidwa kupewa kuyendetsa.

Kuchita ndi mankhwala ena ndi analogi

Yogwira pophika mankhwala mosavuta atengere a oxidative kagayidwe. Pachifukwa ichi, zotsatira za mankhwala ena pazomwe zimachitika canagliflozin ndizochepa.

Mankhwala amalumikizana ndi mankhwala otsatirawa:

Phenobarbital, Rifampicin, Ritonavir - kuchepa kwa mphamvu ya Attokana, kuchuluka kwa mlingo ndikofunikira,
Probenecid - kusowa kwakukulu pamankhwala
Cyclosporin - kusowa kwakukulu kwa mankhwalawa,
Metformin, Warfarin, Paracetamol - sizinawakhudze kwambiri pharmacokinetics ya canagliflozin,
Digoxin ndimayanjano ocheperako omwe amafunika kuwunika momwe wodwalayo alili.

Mankhwala otsatirawa ali ndi vuto lofanana ndi a Attokana:

Glucobay,
NovoNorm,
Jardins
Glibomet,
Phuli
Wotsogolera
Victoza
Chikwanje,
Metamine
Fomu,
Glibenclamide,
Nyama,
Glidiab
Glykinorm,
Wokongola
Trazenta,
Galvus
Glutazone

Malingaliro odwala

Kuchokera pa ndemanga za anthu odwala matenda ashuga okhudzana ndi Invokan, titha kunena kuti mankhwalawa amachepetsa shuga m'magazi komanso zotsatira zoyipa ndizosowa kwenikweni, koma pamakhala mtengo wokwanira wa mankhwala omwe amakakamiza ambiri kuti asinthane ndi mankhwala a analog.

Makanema pazinthu, zizindikiro ndi chithandizo cha matenda ashuga:

Mtengo wa mankhwalawa m'mafakitala umachokera ku 2000-4900 rubles. Mtengo wa analogies ya mankhwalawa ndi ma rubles a 50-4000.

Chogawikacho chimaperekedwa pokhapokha ngati amupatsa katswiri wochiritsa.

Adalimbikitsa Zolemba Zina Zogwirizana

Attokana: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi fanizo

Julia Novgorod analemba 14 Jul, 2015: 214

Irina Antyufeeva, sindinayambe ndalemba za zomwe zimayambitsa T2DM - nthawi zambiri zimapitilira izi.

Ndinalemba za milandu yomwe kugwiritsa ntchito mankhwalawa kukhala kotetezeka molingana ndi ketoacidosis. Chifukwa si chinsinsi kwa aliyense kuti pakati pa odwala onse omwe ali ndi T2DM kulibe gulu laling'ono loti odwala omwe akangotsatira kudya amapatsa zabwino, koma amakakamizidwa kutsatira zakudya mwanjira iliyonse - chifukwa chake: mankhwalawa ndi othandiza kwambiri ndipo ndi otetezeka kwambiri pankhani ya ketoacidosis.

Mapiritsi aikuwa akuti 300 mg 30 ma PC., Pack

Zambiri pazomwe zimachitika pakagwiritsidwe ntchito ka mayesero a testic1 a canagliflozin okhala pafupipafupi ndi ≥2% zimapangidwa mothandizidwa ndi gawo lililonse la ziwalo malingana ndi kuchuluka kwa zomwe zimachitika pogawana zotsatirazi: pafupipafupi (≥1 / 10), pafupipafupi (≥1 / 100,

Matenda am'mimba:
Pafupipafupi: kudzimbidwa, ludzu2, kamwa youma.

Kuphwanya impso ndi kwamikodzo thirakiti:
Pafupipafupi: polyuria ndi polakiuria3, kukodza kwa peremptory, matenda a kwamikodzo4, urosepsis.

Kuphwanya maliseche ndi chithokomole:
Pafupipafupi: balanitis ndi balanoposthitis 5, vulvovaginal candidiasis 6, matenda amkazi.

1 Kuphatikiza ndi monotherapy komanso kuwonjezera pa mankhwala omwe ali ndi metformin, metformin ndi sulfonylurea, komanso metformin ndi pioglitazone. Gulu lomwe lili ndi ludzu limaphatikizanso mawu oti "ludzu", mawu akuti "polydipsia" nawonso ali m'gulu lino.

3 Gawo "polyuria kapena polakiuria" limaphatikizapo mawu akuti "polyuria", mawu oti "kuchuluka kwa mkodzo wambiri" ndi "nocturia" akuphatikizidwanso pagulu lino.

4 Gawo "matenda amkodzo 'limaphatikizanso mawu oti" kwamikodzo matenda amkodzo "ndipo limaphatikizanso mawu akuti" cystitis "ndi" matenda a impso ".

Gulu la "balanitis kapena balanoposthitis" limaphatikizanso mawu akuti "balanitis" ndi "balanoposthitis", komanso mawu akuti "candida balanitis" ndi "matenda oyamba ndi ziwalo". Gawo loti "vulvovaginal candidiasis" limaphatikizapo mawu akuti "vulvovaginal candidiasis", "matenda a fungvovaginal fungus", "vulvovaginitis" komanso mawu oti "venvovaginal and genital fungal matenda".

Zina zoyipa zomwe zimachitika mu maphunziro a placebo olamulidwa ndi placebo ndi pafupipafupi a

Zotsatira zoyipa zomwe zimakhudzana ndi kuchepa kwa magazi a intravascular vol

Kukula kwa mayankho onse osagwirizana ndi kuchepa kwamitsempha yamaitsekedwe (chizungulire chaposachedwa, orthostatic hypotension) 30 mpaka 2) ndi odwala ≥75 wazaka zambiri, pafupipafupi izi zimachitika modabwitsa. Popanga kafukufuku wokhudzana ndi ngozi zamtima, kuchuluka kwa zoyipa zomwe zimakhudzana ndi kuchepa kwa magazi mkati mwazinthu zamkati sizinachuluke ndikugwiritsira ntchito canagliflozin, milandu yotsitsa chithandizo chifukwa cha kusinthika kwatsoka kwamtunduwu kunali kovuta.

Hypoglycemia ikagwiritsidwa ntchito ngati adjunct kupita ku insulin mankhwala kapena othandizira omwe amapangitsa kuti pakhale secretion yake

Pogwiritsa ntchito canagliflozin monga adjunct kuti muchiritsidwe ndi insulin kapena zotumphukira za sulfonylurea, kukula kwa hypoglycemia kumanenedwa pafupipafupi.

Izi zikugwirizana ndikuwonjezereka kwa kuchuluka kwa hypoglycemia pomwe mankhwala, kugwiritsa ntchito komwe sikumayendetsedwa ndi chitukuko cha chikhalidwechi, amawonjezeredwa ndi insulin kapena mankhwala omwe amalimbikitsa katulutsidwe kake (mwachitsanzo, zotumphukira za sulfonylurea).

Zosintha zasayansi

Kuchuluka kwa serum potaziyamu ndende
Milandu yowonjezereka ya seramu potaziyamu ndende (> 5.4 mEq / L ndi 15% kuposa momwe anali oyambira kale) idawonedwa mu 4.4% ya odwala omwe amalandila canagliflozin pa 100 mg, mu 7.0% ya odwala omwe amalandira canagliflozin pa mlingo wa 300 mg , ndi 4.8% ya odwala omwe akulandira placebo.

Nthawi zina, kuchuluka kwakuchulukirapo kwa serum potaziyamu kumawonekera kwambiri kwa odwala omwe ali ndi vuto laimpso zolimbitsa thupi, omwe kale anali ndi kuchuluka kwa ndende ya potaziyamu komanso / kapena omwe adalandira mankhwala angapo omwe amachepetsa potaziyamu (potaziyamu-yosasokoneza diuretics ndi angiotensin-kutembenuza enzyme inhibitors (ACE)).

Pazonse, kuwonjezeka kwa ndende ya potaziyamu kunali kosakhalitsa ndipo sikunafunikire chithandizo chapadera.

Kuchulukitsa kwa serum creatinine ndi urea
M'milungu isanu ndi umodzi yoyambirira atangoyamba kumene chithandizo, panali kuwonjezeka kwapang'onopang'ono kwa ndende ya creatinine (Kuchulukitsa kwa odwala omwe amachepetsa kwambiri GFR (> 30%) poyerekeza ndi gawo loyambirira lomwe limapezeka panthawi iliyonse yamankhwala anali 2.0% - pogwiritsa ntchito canagliflozin muyezo 100 mg, 4.1% mukamagwiritsa ntchito mankhwalawa pa 300 mg ndi 2.1% mukamagwiritsa ntchito placebo Kuchepetsa kumeneku mu GFR nthawi zambiri kumakhala kochepa, ndipo kumapeto kwa kafukufukuyu, kutsika komweko kwa GFR kumaonedwa mwa odwala ochepa. kwa odwala omwe amalephera kupweteka aimpso, kuchuluka kwa odwala omwe ali ndi kuchepa kwakukulu kwa GFR (> 30%) poyerekeza ndi gawo loyambirira lomwe limapezeka panthawi iliyonse ya mankhwalawa anali 9,3% - pogwiritsa ntchito canagliflozin pa mlingo wa 100 mg, 12,2 % - mukamagwiritsa ntchito Mlingo wa 300 mg, ndi 4,9% - mukamagwiritsa ntchito placebo. Mukayimitsa canagliflozin, zosintha izi mu labotale zidapitilira zabwino kapena zidabwezedwa momwe zidakhalira.

Kuchulukitsa Kachulukidwe kakang'ono Lipoprotein (LDL)
Kukula kokhazikika kwa kuchuluka kwa zotsata za LDL kunawonedwa ndi canagliflozin.

Kusintha kwapakati pa LDL ngati kuchuluka kwa koyambirira koyerekeza ndi placebo kunali 0.11 mmol / L (4.5%) ndi 0.21 mmol / L (8.0%) mukamagwiritsa ntchito canagliflozin mu Mlingo wa 100 mg ndi 300 mg, motsatana .

Ambiri a LDL oyambira anali 2.76 mmol / L, 2.70 mmol / L ndi 2.83 mmol / L okhala ndi canagliflozin pa Mlingo wa 100 ndi 300 mg ndi placebo, motsatana.

Kuchulukitsa kwa hemoglobin
Mukamagwiritsa ntchito canagliflozin mu Mlingo wa 100 mg ndi 300 mg, kuwonjezeka pang'ono pa kusintha kwapakati pa hemoglobin m'magawo oyambira (3.5% ndi 3.8%, motsatana) adawonedwa poyerekeza ndi kuchepa pang'ono kwa gulu la placebo (−1.1%).

Kuwonjezeka pang'ono pang'onopang'ono pakusintha kwapakati pa chiwerengero cha maselo ofiira am'magazi ndi hematocrit kuchokera koyambira adawonedwa.

Odwala ambiri adawonetsa kuwonjezeka kwa ndende ya hemoglobin (> 20 g / l), yomwe idachitika mu 6.0% ya odwala omwe amalandira canagliflozin pa 100 mg, mu 5.5% ya odwala omwe amalandira canagliflozin pa mlingo wa 300 mg, ndipo mu 1, 0% ya odwala omwe akulandira placebo. Makhalidwe ambiri adatsalira mu mtundu wamba.

Kutsika seramu uric acid ndende
Pogwiritsa ntchito canagliflozin mu Mlingo wa 100 mg ndi 300 mg, kuchepa kwapakati pa uric acid kuchokera kumayambiriro oyambira (−10.1% ndi −10.6%, motero) kunawonedwa poyerekeza ndi placebo, ndikugwiritsa ntchito komwe kukwera pang'ono pakati pamagawo oyambira (1.9%).

Kuchepa kwa kuchuluka kwa seramu uric acid m'magulu a canagliflozin anali okwanira kapena pafupi kwambiri ndi sabata 6 ndikulimbikira panthawi yonse ya mankhwala. Kukula kwakanthawi kwa uric acid mumkodzo kunadziwika.

Malinga ndi zotsatira za kuphatikiza kophatikizira kwa canagliflozin mu Mlingo wa 100 mg ndi 300 mg, zidawonetsedwa kuti zochitika za nephrolithiasis sizinachuluke.

Kuteteza Mtima
Panalibe chiwopsezo cha mtima ndi canagliflozin poyerekeza ndi gulu la placebo.

Attokana: ndemanga, mtengo, malangizo ogwiritsira ntchito

Mankhwala a Invokana ndi ofunikira kuthandizira odwala matenda a shuga a mtundu 2. Chithandizo cha mankhwalawa chimaphatikizapo kuphatikiza zakudya zowonjezera, komanso masewera olimbitsa thupi nthawi zonse.

Glycemia idzasinthidwa kwambiri chifukwa cha monotherapy, komanso ndi mankhwala othandizirana ndi othandizira ena a hypoglycemic.

Contraindication ndi mawonekedwe ogwiritsa ntchito

Mankhwala a Invokana sangathe kugwiritsidwa ntchito ngati:

Hypersensitivity to canagliflozin kapena chinthu china chomwe chimagwiritsidwa ntchito ngati chothandizira,
mtundu 1 shuga
matenda ashuga ketoacidosis,
kulephera kwambiri kwaimpso
kulephera kwambiri kwa chiwindi,
Mimba ndi kuyamwa
ana ochepera zaka 18.

Panthawi yapakati komanso yoyamwitsa, maphunziro amomwe thupi limayankhira mankhwalawo sanachitike. Poyeserera nyama, sizinapezeke kuti canagliflozin ili ndi njira yosawonekera kapena yoyipa yazokhudza dongosolo la kubereka.

Komabe, momwemo, kugwiritsa ntchito mankhwalawa ndi amayi nthawi imeneyi kumalimbikitsidwa kwambiri, chifukwa chopangira chofunikira kwambiri chimatha kulowa mkaka wa m'mawere ndipo mtengo wa chithandizo chotere ungakhale wopanda chifukwa.

Mlingo ndi makonzedwe

Mankhwala tikulimbikitsidwa kugwiritsa ntchito pakamwa kamodzi patsiku lisanafike chakudya cham'mawa.

Kwa odwala matenda ashuga a mtundu wa 2, mankhwalawa azikhala 100 mg kapena 300 mg kamodzi tsiku lililonse.

Ngati canagliflozin amagwiritsidwa ntchito ngati adjunct ndi mankhwala ena (kuphatikiza insulin kapena mankhwala omwe amapangitsa kuti apangidwe), ndiye kuti kuchepetsa kochepetsetsa kumachepetsa mwayi wa hypoglycemia.

Nthawi zina, pamakhala zotheka kuti pakhale zovuta zina. Amatha kuphatikizidwa ndi kuchepa kwa kuchuluka kwa intravascular. Izi zitha kukhala kuzungulira kwa postural, ochepa kapena orthostatic hypotension.

Tikulankhula za odwala otere omwe:

adalandira zowonjezera zowonjezera,
kukhala ndi mavuto ndi impso zoyenera,
ali ndi ukalamba (woposa zaka 75).

Poona izi, magulu awa a odwala ayenera kumwa canagliflozin mu mlingo wa 100 mg kamodzi kadzutsa.

Odwala omwe akumana ndi vuto la hypovolemia adzalandiridwa poganizira kusintha kumeneku asanayambe mankhwala a canagliflozin.

Odwala omwe amalandira 100 ml ya mankhwala a Attokan ndikuwathandiza bwino, komanso amafunikira kuwongolera shuga, adzasamutsidwira ku mlingo wa 300 mg wa canagliflozin.

Wodwala akaphonya mlingo pazifukwa zilizonse, ndiye kuti ziyenera kumwedwa mwachangu. Komabe, ndizoletsedwa kumwa kawiri kwa maola 24!

Zotsatira zoyipa za mankhwalawa

Kafukufuku wapadera wa zamankhwala adachitidwa kuti akhazikitse mfundo zokhudzana ndi zovuta zomwe zimagwiritsidwa ntchito ndi mankhwalawa. Zomwe zidalandilidwa zidakonzedwa malinga ndi dongosolo lililonse komanso pafupipafupi zomwe zimachitika.

Iyenera kuganizira zovuta zomwe zimadza chifukwa chogwiritsa ntchito canagliflozin:

kugaya chakudya cham'mimba (kudzimbidwa, ludzu, pakamwa pouma),
kuphwanya impso ndi kwamikodzo thirakiti (urosepsis, matenda opatsirana kwamkodzo, polyuria, polakiuria, chilimbikitso peremptory kutulutsa mkodzo),
mavuto kuchokera ku tchire ta mammary ndi ziwalo zam'mimba (balanitis, balanoposthitis, matenda amkazi, vulvovaginal candidiasis).

Zotsatira zoyipa za thupi zimachokera ku mototherapy, komanso chithandizo chomwe mankhwalawa adathandizidwa ndi pioglitazone, komanso sulfonylurea.

Kuphatikiza apo, zovuta zomwe wodwalayo ali ndi mtundu wachiwiri wa matenda ashuga zimaphatikizanso zomwe zimapangidwa poyeserera kwa canagliflozin poyeserera pafupipafupi 2 peresenti.

Tikukamba za zosakhudzika zosakhudzana zomwe zimakhudzana ndi kuchepa kwa mitsempha yamitsempha, komanso urticaria ndi totupa pakhungu.

Tiyenera kudziwa kuti kuwonetsa khungu pakokha ndi matenda a shuga siachilendo.

Zizindikiro zazikulu za mankhwala osokoneza bongo

Muzochita zachipatala, mpaka pano, milandu ya kumwa kwambiri wa canagliflozin sichinalembedwe. Ngakhale mankhwala osachepera omwe amafika 1600 mg mu anthu athanzi ndi 300 mg patsiku (kwa masabata 12) mwa odwala omwe ali ndi matenda a shuga a 2 amaloledwa nthawi zonse.

Ngati mankhwalawa awonjezeka, ndiye kuti mtengo wake ndikuwukhazikitsa njira zothandizira.

Njira yochizira bongo ndi kuchotsera zotsalira za chinthu chogwiritsa ntchito m'magazi, komanso kukhazikitsa kuyan'ana ndi chithandizo chachipatala, poganizira momwe alili.

Kanagliflosin sangathe kuchotsedwa pa nthawi ya maola 4 oyimba. Poona izi, palibe chifukwa chonenera kuti chinthucho chidzapukutidwa kudzera mu peritoneal dialysis.

Invokana ndi chithandizo chathanzi la matenda ashuga

Mankhwala osokoneza bongo a mtundu wachiwiri wa matenda a shuga, madokotala amatenga mankhwala a Invokan, omwe amawongolera shuga wamagazi, amaletsa kukula kwa matenda a shuga, ndipo amatha nthawi yayitali kuti chikhululukiro cha matenda oyambitsidwa.

Wothandizira wa hypoglycemic pakuchita bwino kwambiri ayenera kuphatikizidwa ndi zakudya zoyenera, kukana kwathunthu zizolowezi zoyipa ndikuwonjezera mankhwala. Mankhwala othandizira amakhala a nthawi yayitali, koma amakhala ndi zotsatirapo zabwino muumoyo wonse.

Izi zimatsimikiziridwa ndikuwunika kambiri kwa odwala ndi madokotala.

Kufotokozera ndi malangizo ogwiritsira ntchito mankhwala a Captokana

Mankhwala a hypoglycemic amapezeka mu mawonekedwe a mapiritsi onenepa yokutidwa ndi chipolopolo chamafuta achikasu, omwe cholinga chake ndi kutsata pakamwa mokwanira. Odwala amatha kugwiritsa ntchito mankhwala a Invokan ngati chithandizo chodziimira payekha, kapena ngati gawo limodzi la zovuta popanga mankhwala a insulin.

Yogwira ntchito ya Invocan ndi canagliflozin hemihydrate, yomwe imayambitsa kuchuluka kwa shuga m'magazi. Cholinga chake kwa wodwala ndichoyenera mtundu wa matenda ashuga a 2.

Koma ndi matenda amtundu woyamba wamtunduwu, kuikidwa kwake kumatsutsana kwambiri.

Zomwe zimapangidwa mu mawonekedwe a Invocan amapangidwa mozama mu kayendedwe ka kayendedwe kazinthu, zimafalikira m'chiwindi, ndipo zimatsitsidwa ndi impso mkodzo.

Attokana samalimbikitsidwa kuti azigwiritsidwa ntchito ndi amayi panthawi yoyembekezera komanso pakubala. Zoletsa zamankhwala zimagwiranso ntchito pazotsatira zamankhwala zotsatirazi:

Hypersensitivity kwa yogwira zinthu,
matenda ashuga ketoacidosis,
zoletsa zaka mpaka 18,
Kulephera kovuta kwa aimpso,
kulephera kwa mtima
kulephera kwambiri kwa chiwindi.

Payokha, ndikofunikira kuwunikira zoletsa zokhudzana ndi odwala pakati komanso amayi oyamwitsa. Kafukufuku wamankhwala wokhudzana ndi mankhwala a Attokana am'magulu awa sanachitidwire, chifukwa chake madotolo amangoopa kusankhidwa kwawo chifukwa cha umbuli.

Ngati chithandizo chikufunika, palibe choletsa malinga ndi malangizo a Attokan, ndikungoti wodwalayo ayenera kuyang'aniridwa mosamala panthawi ya chithandizo kapena prophylactic.

Phindu kwa mwana wosabadwayo liyenera kukhala lokwera kuposa momwe lingasokonezere chitukuko cha intrauterine - pokhapokha pokhapokha kuikidwa ndikothandiza.

Mankhwalawa amatha kusinthika mthupi, koma kumayambiriro kwenikweni kwa chithandizo chamankhwala kumatha kuyambitsa mavuto. Nthawi zambiri imakhala kugayikana mu mawonekedwe a chotupa cha hemorrhagic komanso kuyabwa kwambiri pakhungu, chizindikiro cha dyspepsia ndi mseru.

Pankhaniyi, makina a Invocan ayenera kusiidwa, limodzi ndi katswiri, sankhani analogue, sinthani othandizira. Milandu yambiri imakhala yangozi kwa wodwalayo, chifukwa amafunika chithandizo cham'mbuyo posachedwa.

Njira ntchito, tsiku lililonse Mlingo wa mankhwala akuti

Mlingo wa tsiku ndi tsiku wa mankhwala a Invokana ndi 100 mg kapena 300 mg ya canagliflozin hemihydrate, omwe amawonetsedwa kamodzi patsiku. Kukonzekera kwa pakamwa kwa odwala opitirira zaka 18 kukuwonetsedwa musanadye kadzutsa - kokha pamimba yopanda kanthu. Kuphatikiza ndi insulin, Mlingo wa tsiku ndi tsiku uyenera kusinthidwa payekhapayekha kuti muchepetse ndikuchepetsa kwambiri chiopsezo cha hypoglycemia.

Ngati wodwalayo adayiwala kumwa kamodzi, ndiye kuti ndikofunikira kumwa piritsi mukakumbukira kaye kaye za panjira. Ngati chidziwitso chodumpha mlingo chinangofika pa tsiku lachiwiri, kumwa kawiri pamlomo kumangokhala kotsutsana. Ngati mankhwalawa amalembera ana, achinyamata kapena opuma pa zaka 75, ndikofunikira kuchepetsa mlingo wa tsiku ndi tsiku kufika pa 100 mg.

Popeza mankhwalawa amathandizira pakukonzekera kwina kwa magazi, ndizosatheka kudyetsa mowonjezereka miyezo yatsiku ndi tsiku ya Invokan. Kupanda kutero, wodwalayo amayembekeza kuti azisanza pamatumbo chifukwa cha kusanza kwachidziwikire, kudya zina zowonjezera, chithandizo chamankhwala chifukwa cha zamankhwala.

Mndandanda wa mankhwala a Captokana

Mankhwala omwe adalankhulidwawo sakhala oyenera kwa odwala onse, ndipo mndandanda wazotsatira zomwe zikuwonetsedwa m'malangizo amatsimikiziranso kuopsa kwa nthawi yayitali ngati akuphwanya malangizo a chipatala. Pakufunika kugula ma analogues, omwe mankhwalawa adatsimikizira bwino:

Ndemanga za Callokana

Mankhwala omwe adanenedwa ndi otchuka pakati pa odwala omwe ali ndi matenda a shuga a mtundu wachiwiri. Aliyense amalemba pamabwalo azachipatala za kuthekera kwambiri kwa Attokan, kwinaku akukumbukira kuti adadzidzimuka pamiyeso yododometsa.

Mtengo wa mankhwalawa ndiwokwera, pafupifupi ma ruble 1,500, kutengera mzinda wogula ndi mtundu wa mankhwalawo.

Omwe adapeza izi adakhutira ndi zomwe adatenga, popeza shuga adakhala wokhazikika mwezi umodzi.

Odwala omwe ali ndi matenda a shuga akuti ngati mankhwala a Attokan satsimikiza kuti achira, komabe, kuwonekera kwakukulu mwa omwe ali ndi "matenda ashuga" ndikwachidziwikire.

Zizindikiro zingapo zosasangalatsa zimasowa, mwachitsanzo, ma membala owuma a mucous ndikumangokhala ndi ludzu, ndipo wodwalayo amadzimvanso kuti ndi munthu wokhazikika.

Odwala ambiri omwe ali ndi matenda ashuga amafotokoza milandu ikakhungu pakadutsa khungu ndipo mantha amkati amwalira.

Zolemba zoyipa za Attokana zimapezeka pazocheperako, ndipo pazomwe zimapezeka pazachipatala zimangowonetsa mtengo wokwera wa mankhwalawa, kukhalapo osati m'mafakitala onse amzindawu.

Ponseponse, mankhwalawa ndi abwino, chifukwa amathandiza wodwala matenda ashuga kuthana ndi magazi, kupewa kukokomeza kosafunikira, zovuta komanso kudwala matenda ashuga.

Irina Antyufeeva adalemba pa 14 Jul, 2015: 17

Monga mtundu wachiwiri wa odwala matenda ashuga, sindimakonda za mankhwalawa kuti samachepetsa kukana kwa maselo kupita ku insulin, sikuwongolera ndipo sikuletsa kupangika kwambiri kwa chamba cha inshuwaransi yeniyeni chifukwa inshuwaransi yamtundu wa 2 wodwala matenda ashuga imapitiliza kugwira ntchito mopitilira muyeso kuchepa msanga, kuwatanthauzira kukhala anthu olumala omwe amadwala kwambiri insulin omwe sagwiritse ntchito zodziletsa pa chilichonse).
Komanso, zotsatira zonse zomwe mwapeza chifukwa chogwiritsa ntchito ma invocans.
Ndikuganiza kuti mutha kuganiza zongotenga pokhapokha ngati simungalole mankhwala ena kapena - komanso kwa nthawi yochepa - pazovuta zina, pomwe palibe china.

Julia Novgorod analemba 14 Jul, 2015: 117

Tizinena kuti, mosiyana ndi mankhwala ambiri a T2DM, sizikulimbikitsa kupanga insulini komanso zimapangitsa kuti achepetse thupi, zomwe zikutanthauza kuti kukana pakapita nthawi yayitali ndi kuphatikiza kwakukulu, pomwe mankhwala omwe amachepetsa insulin kwambiri.

Ndinawerenga paukonde zomwe anthu omwe anali nawo kale amakhala ku Germany, omwe amadwala T2DM posachedwapa ndipo adavomereza modzitchinjiriza kuti azikhala ndi chakudya: anali atayesapo popanda phindu lililonse mitundu yonse ya mankhwala omwe amatsitsa shuga, shuga inali yayikulu ndipo inali funso kale insulini - koma anali mankhwala a gululi omwe adamulola, popanda kudzikana yekha zokondweretsa, kuti achepetse osati kuchuluka kwa shuga, komanso kulemera. Ndikuganiza kuti palibe mankhwala omwe amapezeka m'magulu ena opanga mankhwala popanda kudya sangathe.

Irina Antyufeeva adalemba pa 14 Jul, 2015: 36

Sizokhudza insulinophobia. Kudalira kwa insulini ndi kutchulidwa kosafunikira, ndiye kuti, chitetezo chokwanira cha maselo kupita ku insulin (chomwe ndi chizindikiro chachikulu cha CD-2) ndicholemala kwambiri. Insulin imaperekedwa kwa thupi, koma sichidziwikiridwa ndi maselo, chifukwa cha CD-2 sichitha. Maselo akadali ndi njala, choncho, kuwopa, kumva kutopa kosalekeza ndi njala yosatha. SC yapamwamba (popeza glucose simalowa m'maselo) imagwira ntchito yake yowonongeka.

Kupita patsogolo kwaposachedwa komanso chiyembekezo cha kupewa matenda a shuga 1

Pakadali pano, zitha kuyesa chiwopsezo cha kukhala ndi matenda amtundu wa 1 osati m'mabanja a odwala, komanso kwa anthu ambiri. Mofananamo, kusaka kukuchitika njira zatsopano zachipatala zothandizira odwala matenda ashuga. Kupita patsogolo komweku kumayambitsa nyengo yatsopano popewa matenda ashuga 1.

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Amakupatsirani zabwino kuposa alendo okhazikika:

Mpikisano ndi mphoto zamtengo wapatali
Kuyankhulana ndi mamembala amakalabu, kukambirana
Nkhani Za Matenda Ashuga Sabata Iliyonse
Macheza ndi mwayi wokambirana
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