Malangizo ndi zikuwonetsa kugwiritsa ntchito mankhwala Zokor ndi analogies

Amapezeka mwanjira ya mapiritsi, omwe amaphatikizidwa. Mapiritsi 10 mg simvastatin, khalani ndi mtundu wa pinki wowala, mawonekedwe osalala mbali inayo, mbali inayo pali zolemba "MSD 735«.

20 mg mapiritsi simvastatinkhalani ndi utoto wonyezimira, mawonekedwe osalala mbali imodzi, mbali inayo pali zolemba "MSD 740«.

Zokor Forte likupezeka ngati malembedwe apinki, okhala ndi mawonekedwe osalala mbali inayo, mbali inayo pali zolemba "MSD 749«.

Chotupacho chili ndi mapiritsi 14, m'bokosi pamakhala matuza amodzi kapena awiri.

Zotsatira za pharmacological

Mankhwalawa ali ndi tanthauzo la hypolipidemic. Piritsi ili ndi chophatikizira simvastatin, pakukonzekera ma hydrolysis kukhala magawo ena othandizira. Metabolite ya simvastatin imalepheretsa enzyme HMG-CoA reductase. Enzyme iyi imatenga nawo gawo loyamba la biosynthesis. cholesterol.

Zotsatira zake, motsogozedwa ndi Zokor, kuchuluka kwa cholesterol m'thupi kumachepetsedwa bwino, komanso zomwe zili mu cholesterol, zomwe zimagwirizanitsidwa ndi lipoprotein otsika kwambiri. Zomera ya plasma cholesterol ya triglycerides imachepetsedwa.

Nthawi yomweyo, mukatenga simvastatin, kuchuluka kwa cholesterol, yomwe imalumikizidwa ndi lipoproteins yapamwamba, imachulukitsidwa kwambiri.

Mphamvu ya mankhwala omwe ali ndi mitundu yosiyanasiyana amadziwika. Hyperlipidemia, makamaka ndi heterozygous, banja, osakhala banja. Komanso, mankhwalawa amagwira ntchito zamitundu yosiyanasiyana mu hyperlipidemia Zakudya sikokwanira kusintha mapiritsi a plasma.

Kuchuluka kwa lipids mu plasma kumachepera masiku 14 atayamba chithandizo. Pankhaniyi, mfundo zapamwamba zimawonedwa pamasabata a 4 a chithandizo. Komanso, mukamamwa mankhwalawa, zotsatira zake zimapulumutsidwa.

Mankhwalawo atatha, pang'onopang'ono zisonyezo za cholesterol yathunthu m'madzi am'magazi zimabwereranso ku mfundo zoyambirira, zomwe zimadziwika asanamwe mankhwalawa.

Pharmacokinetics ndi pharmacodynamics

Kupezeka kwakukulu kwa simvastatin metabolites m'magazi kumadziwika kuti maola 1.5-2.4 munthu atamwa mlingo umodzi wa mankhwalawo. Pafupifupi 85% ya simvastatin yomwe imatengedwa pakamwa imalowa m'thupi.

Pambuyo pakukonzekera kwamkati, poyerekeza ndi zimakhala zina, kuphatikizira kwazomwe zimagwira kumadziwika.

M'ndime yoyamba kudzera m'magazi a chiwindi, simvastatin imapangidwira, pambuyo pake mankhwala ndi ma metabolites amachotsedwa m'thupi ndi bile.

Kudya chakudya mukangomwa mankhwalawa sikuphwanya mankhwala a pharmacokinetics. Ndi chithandizo chazitali, simvastatin siziunjikira mu minofu ya thupi.

Zizindikiro zogwiritsidwa ntchito

Kugwiritsa ntchito kwa Zokor kumawonetsedwa kwa anthu omwe ali m'gulu lomwe ali pachiwopsezo chachikulu chotukuka matenda a mtima kaya lipids yamagazi. Gulu lamavuto limaphatikizapo anthu omwe ali ndi mikhalidwe yotsatira:

• cerebrovascular pathologies, kuphatikizapo sitiroko(mbiri)
• matenda ashuga(mankhwalawa atha kulepheretsa kuwonekera kwa zotumphukira zamitsempha yamagazi ndikuchepetsa kufunikira kwa kukonzanso komanso kudula kwam'munsi),
• matenda a zotumphukira magazi.

Mankhwalawa amagwiritsidwa ntchito pochiza anthu omwe ali ndi matenda a mtima komanso odwala ndi hypercholesterolemia. Pankhaniyi, Zokor imaletsa mawonetseredwe a zotupa zam'matumbo mu mtima, kukula kwa zovuta zina.

Zokor imafotokozedwanso kwa odwala achikulire omwe ali ndi vuto lotere:

• anthu omwe ali ndi milingo yayikulu kwambiri cholesterol, apolipoprotein Bkomanso cholesterol, yomwe imagwirizanitsidwa ndi lipoprotein yotsika, pamodzi ndi zakudya,
• ndi hypertriglyceridemia,
• ndi cholesterol yotsika kwambiri ya lipoproteins yapamwamba, yomwe imalumikizidwa ndi hypercholesterolemia yayikulu pakudya,
• ndi homozygous mtundu wa hypercholesterolemia limodzi ndi njira zina zamankhwala ndi zakudya.

Contraindication

Zopanda malire pazogwiritsa ntchito Zokor ndi:

• mayamwidwe ndi metabolism wa lactose,
• matenda owopsa a chiwindi, chiwopsezo chambiri komanso chokhazikika cha kuchuluka kwa ma transaminase achilengedwe osadziwika,
• kusalolera payekhab
• mimba ndi kudyetsa kwachilengedwe,
• zaka mpaka 10.

Zoyipa zokhudzana ndi kugwiritsidwa ntchito kwa Zokor ndi:

Zikatero, mankhwalawa amayikidwa mosamala.

Mlingo ndi makonzedwe a Zokor forte

Asanayambe komanso kuthandizira, ayenera kudya zakudya za hypocholesterol. Mkati, muyezo woyambirira wa 10 mg kamodzi, madzulo, ndi Hypercholesterolemia yofatsa kapena yolimbitsa mlingo woyambirira ndi 5 mg, ngati ndi kotheka, mlingo umakulitsidwa pang'onopang'ono pakadutsa masabata anayi. Ndi mabanja homozygous hypercholesterolemia Tsiku mlingo - 40 mg kamodzi, madzulo kapena 80 mg / tsiku (kugawa 3 waukulu - 20 mg m'mawa, 20 mg masana, 40 mg madzulo). Ndi matenda a mtima mlingo woyambirira ndi 20 mg, kamodzi, madzulo, ngati kuli kotheka, amawonjezedwa pang'onopang'ono pakadutsa masabata anayi mpaka 80 mg.

Zokor forte

Mutu, chizungulire, asthenia, dyspepsia, hepatitis / jaundice, kapamba, minyewa, myalgia, myopathy, rhabdomyolysis, paresthesia, zotumphukira neuropathy, kuchepa kwa magazi, alopecia, zotupa pakhungu, pruritus, hypersensitivity reaction , kupuma movutikira, malaise ambiri, angioedema, lupus ngati matenda, polymyalgia rheumatism, vasculitis, nyamakazi, arthralgia, kuchuluka kwa ESR, thrombocytopenia, eosinophilia), matenda a labot (kuchuluka kwa trans wotchedwa alkaline phosphatase, gamma-glutamyltranspeptidase, chigoba minofu creatine phosphokinase, kusintha kwa mayeso a chiwindi ntchito).

Mu milandu ingapo yodziwika bwino ya bongo (450 mg wambiri), palibe zizindikiro kapena zotsatira zake zomwe zapezeka. Mankhwala othandizira amagwiritsidwa ntchito.

Moder amatha zotsatira za coumarin anticoagulants. Akaphatikizidwa ndi cyclosporine, itraconazole, ketoconazole, michere yokhala ndi michere acid, niacin, erythromycin, clarithromycin, proteinase inhibitors, nefazodone, chiopsezo cha rhabdomyolysis chimawonjezeka. Kuchiza kuyenera kusiyidwa ngati myopathy yatsimikiziridwa kapena kukayikiridwa.

Musanayambe chithandizo, ndikofunikira kuchita (kenako ndikubwereza) kafukufuku wama chiwindi. Mulingo wa transaminases ukayamba kupitirira malire amtunda ndi katatu, mankhwalawo amaletsedwa. Amalembedwa mosamala kwa odwala omwe amamwa mowa kwambiri / komanso omwe ali ndi mbiri yodwala matenda a chiwindi.

Pewani kufikira ana.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Mutha kuona kufanana kwa Zokor forte m'magulu oyenera, otsika mtengo komanso okwera mtengo:

Mankhwala awa ndi a gulu "Atherosulinosis". Komanso m'gululi mulinso: Dipromonium, Brilinta, Benzaflavin

Chida ichi ndi cha gulu la "matenda a cerebrovascular." Komanso m'gululi mulinso: Actovegin concentrate, NICOTINIC ACID-VIAL, Kapilar

Zotsatira zoyipa

Zotsatira zoyipa zoterezi zimatha kuchitika panthawi ya odwala omwe ali ndi Zokor:

• kusapeza bwino ndi kupweteka pamimba, kutulutsa, kusokonezeka,
• mutu kumverera kwofooka wamba kuchepa magazi,
• chizungulirekukokana zotumphukira neuropathy, paresthesiakukumbukira ndi kugona,
• zotupa pakhungu, alopecia, kuyabwa.

Nthawi zina, amakula myopathy, rhabdomyolysismukutenga simvastatin, komanso kuchepa kwa chiwindi. Nkhani zachitukuko cha myalgia zidalembedwa. Mwambiri, Zokor imalekeredwa bwino ndi odwala.

Ndi hypersensitivity kwa mankhwalawa, edema ya Quincke, vasculitis imatha dermatomyositisthrombocytopenia, eosinophilia, nyamakazi, Kuchuluka kwa ESR, arthralgia ndi ena

Malangizo ogwiritsira ntchito Zokora (Njira ndi Mlingo)

Malangizo ogwiritsira ntchito Zokora amapereka kuti wodwalayo amwe mapiritsi pakamwa, mosasamala chakudya. Mlingo wa tsiku ndi tsiku wa mankhwalawa uyenera kutengedwa madzulo, palibe chifukwa chogawa magawo angapo.

Mlingo wamba wa simvastatin patsiku ndi 5-80 mg. Zoposa 80 mg za simvastatin patsiku siziyenera kumwa.

Dokotala amasankha mlingo, pamene nthawi zonse amaganizira mulingo wa lipids mu plasma. Mlingo umasinthidwanso kamodzi pamasabata anayi.

Pofuna kupewa komanso kulandira chithandizo Matenda a mtima wa Ischemic motsutsana ndi zakudyazi, tsiku lililonse 40 mg ya simvastatin imayikidwa.

At hypercholesterolemiaNgati mankhwala a zakudya samapereka zotsatira zoyenera, tsiku lililonse 20 mg ya simvastatin patsiku ndi mankhwala. Ngati zomwe zili mu plasma lipid zikufunika kuchepetsedwa ndi 45% kapena kupitilira, mlingo woyambirira patsiku ukhoza kukhala 40 mg.

Ngati wodwala ateropang'ono kapena mawonekedwe ofatsa a hypercholesterolemia, ndiye kuti patsiku mlingo umachepetsedwa mpaka 10 mg.

Dokotala amadziwitsa mtundu wofunikira wa mankhwalawa, kuyeza milingo ya lipids ndikuwunika momwe mankhwalawo amathandizira poyambira chithandizo. Ngati milungu inayi itatha, mankhwala omwe akuyembekezeredwa samawonekera, pamenepa, mankhwalawa amawonjezeka, koma pang'onopang'ono, kufikira atadziwika.

At homozygous achibale hypercholesterolemia motsutsana ndi zakudya ndi njira zina zamankhwala, kumwa kwa poyambira kwa Zokor kuyenera kukhala 40 mg patsiku, kapena 80 mg ya simvastatin ndi mankhwala omwe amawonjezera 20 mg wa mankhwalawa ndi 40 mg madzulo.

Achinyamata omwe ali ndi homozygous achiberekera hypercholesterolemia amapatsidwa mankhwala 10 mg patsiku. Mlingo wapamwamba kwambiri wa tsiku lililonse wa achinyamata ndi 40 mg.

Kuchita

A zabwino zambiri amawoneka ndi munthawi yomweyo Zokor komanso obwezeretsanso a bile acids.

Ndi munthawi yomweyo makonzedwe a fibrate, cyclosporine ndi lipid-kutsitsa Mlingo wa niacin patsiku, simungatenge zosaposa 10 mg za mankhwala Zokor.

Anthu olandila Verapamil ndi Amiodaroneosamamwa oposa 20 mg a simvastatin patsiku.

Simvastatin sachita ntchito ya enzymatic ya CYP3 A4.

Ndi munthawi yomweyo mankhwala omwe amalepheretsa ntchito ya CYP3 A4, mwayi wopanga myopathy ndi rhabdomyolysis mwa iwo omwe amatenga simvastatin amawonjezeka. Ndikofunikira kuti musaphatikize ndi Zokor ndi itraconazole, Erythromycin, nefazodone, ketoconazole, telithromycin.

Mwayi wopanga myopathy ndi rhabdomyolysis ukuwonjezeka pamene mukutenga amiodarone, diltiazema, gemfibrozil, cyclosporine, niacin, fusidic acid, danazole, verapamil, michere.

Mothandizidwa ndi Zokor amakulitsa zotsatira zake coumarin anticoagulants.

Potenga madzi okwanira 1 litre a madzi a mphesa patsiku, kuwonjezeredwa kwakukulu kwa plasma kwa simvastatin kumadziwika, komwe kumawonjezera mwayi wa rhabdomyolysis.

Mukamatenga 20-25 mg wa simvastatin patsiku, zotsatira zake zimatha coumarin anticoagulants. Zotsatira zake, chiopsezo chakutuluka magazi chikuwonjezeka.

Zokor Forte - mankhwala ochizira matenda a mtima ndi matenda a mtima

Zokor Forte ndi imodzi mwamankhwala omwe amagwiritsidwa ntchito pochiza matenda a mtima ndi matenda ena a mtima.

Mankhwalawa amaperekedwa mwanjira yabwino piritsi, ndipo maziko ake ndi hypolipedimic chinthu simvastatin.

Kugwiritsa ntchito mankhwalawa malinga ndi malangizo kumachepetsa chiopsezo cha kufa kwa odwala omwe ali ndi matenda amtima.

Nthawi zambiri, imwani mapiritsi a Zocor Forte kamodzi patsiku pazomwe ananena dokotala.

Musanayambe maphunziro, ndikofunikira kuti mudziwe bwino mbali zonse za mankhwalawa, komanso muziganizira zovuta komanso zotsutsana.

Kodi Zokor Forte amagwirizana bwanji ndi mankhwala ena?

Musanayambe kumwa mapiritsi a Zokor Forte, muyenera kuyang'anira mawonekedwe a kuyanjana ndi mankhwala ena.

Ndi makonzedwe ake amodzi pamodzi ndi danazol, verapamil, amiodarone kapena cyclosporine, chiopsezo chokhala ndi myopathy chikuwonjezeka.

Kugwiritsa ntchito munthawi yomweyo kwa Zokora Forte ndi mankhwala omwe ali amodzimodzi amadzimadzi a bile acid kumapereka chothandiza.

Tiyeneranso kukumbukira kuti pali mitundu ingapo ya mankhwala omwe amakhudzidwa kuti atenge molumikizana ndi mapiritsi a Zokor Forte. Izi zikuphatikiza:

• erythromycin,
• itraconazole,
• ketoconazole
• telithromycin
• nefazodone.

Kamangidwe ka lipid-kutsitsa wothandizila

Kuphatikiza pa gawo lokhazikika la simvastatin, mapiritsi a Zokor pakupanga kwawo ali ndi zinthu zina. Zina mwa izo ndi:

• lactose ndi hypromellose,
• MCC
• ascorbic ndi citric acid,
• wowuma chimanga
• magnesium wakuba,
• iron oxide (wachikasu ndi wofiyira).

Pharmacodynamics ndi pharmacokinetics

Zokor imalepheretsanso kuchepa kwa HMG-CoA ndi metabolites ndikuletsa kuphatikizira kwa mevalonate, komwe kumachepetsa kupanga ma smarols ndi mamolekyulu a cholesterol. Kuphatikiza ndi zoletsa zina, mankhwalawa amathandizira ma receptors mu maselo a chiwindi omwe amayankha ma lipids otsika kwambiri. Ma receptor awa amalanda mamolekyu a chidutswa cha LDL ndikuwonjezera mphamvu zawo.

Limagwirira a zochita za statins

Kuletsa kwa HMG-CoA reductase ndi simvastatin kumabweretsa mphamvu yotereyi pakutenga statin:

• kutsitsa kwathunthu cholesterol
• kutsitsa kachidutswa ka LDL,
• kutsitsa mamolekyulu a triglycerides ndi kachigawo kakang'ono kokhala mafuta m'thupi la VLDL,
• kutsika kwa apolipoprotein B,
• milomo yapamwamba kwambiri (HDL) ikufika - 14.0%,
• kuchuluka kwa index ya apoA.

Kugwiritsa ntchito koyamba kwa mankhwala kuchokera kwa Zokor kumatha kumveka pakatha milungu iwiri, ndipo pazofunikira - pambuyo pa masiku 30 cm a kalendala.

Pharmacokinetics Zokor m'thupi la munthu ikuwonetsedwa motere:

• kuchuluka kwambiri kwa simvastatin m'magazi ndi theka ndi theka kwa maola awiri atayamwa. Kuwonekera kumadalira mlingo womwe dokotala watchulidwa.
• ntchito yogwira imagwira thupi osapitirira 85% ya mankhwalawa omwe amamwa pakamwa,
• bioavailability wa mankhwala - 20%,
• mankhwala amalowa placental zotchinga pa mimba,
• 95% ya mankhwalawa amamangidwa kumapuloteni ndi mankhwala awo,
• palibe kuchuluka kwa simvastatin m'thupi, yomwe imakupatsani mwayi wogwiritsa ntchito mankhwalawa kwa nthawi yayitali,
• Hafu ya moyo wa simvastatin imachokera ku 18 mpaka 20 maola,
• Zokor imachotsedwa ndi 70% mothandizidwa ndi bile acid komanso matumbo okhala ndi ndowe,
• 10% ya chinthu chachikulu chimapukusidwa mkodzo.

Zizindikiro zogwiritsidwa ntchito ndi contraindication

Fotokozerani za lipid-kuchepetsa wothandizila Zokor pochizira matenda ena a m'mitsempha. Zina mwa izo ndi:

• chachikulu heterozygous achibale hypercholesterolemia,
• homozygous genetic hyperlipidemia,
• Hypercholesterolemia
• dysbetalipoproteinemia kuwonjezera pa zakudya,
• hypertriglyceridemia kuphatikiza zakudya.
• Kuchepetsa kukula kwa systemic atherosulinosis.

Komanso, mankhwalawa amatchulidwa ngati njira yachiwiri yolepheretsera pambuyo pobadwa pambuyo povulala.

Kugwiritsa ntchito statin kwa prophylactic zolinga kumathandizanso, monga:

• kupewa kubadwa kwa myocardial infarction ndi matenda a mtima,
• sinthani kuchulukana kwamatenda komanso kuphedwa kwamphamvu pamaso pa izi.
• kutsekereza pafupipafupi ndi mphamvu ya ischemic pang'onopang'ono kuukira,
• kuyimitsidwa kwa kupitirira kwa systemic atherosulinosis,
• kutsitsa kachigawo ka cholesterol cha LDL, ndikukulitsa kachidutswa ka HDL m'madzi a m'magazi.

Contraindication kuma statins

Ma Statin sanatchulidwe zinthu zoterezi ndi zovuta m'mthupi la wodwalayo:

• tsankho pamagawo ndi lactose,
• kuchuluka kwamankhwala m'maselo a chiwindi,
• matenda a chiwindi mu pachimake siteji ya chitukuko cha matenda,
• mitundu yosiyanasiyana ya hepatitis ndi matenda enaake,
• minofu myopathy
• mbiri yamatenda am'mimba mwa wodwala
• pa mimba ndi kuyamwa,
• ana ochepera zaka 10.

Amayi omwe ali ndi zaka zoberekera amapatsidwa mankhwala okhawo omwe amakhala ndi chitetezo chamthupi chokwanira. Ngati mayi wapezeka kuti ali ndi pakati panthawi yochizira, mankhwalawa amathetsedwa, chifukwa simvastatin imadutsa chotchinga ndipo ikhoza kukhudza mapangidwe a mafupa ndi minofu mu fetus, komanso imayambitsa kukula kwa intrauterine kwa ma cell a ma cell a chiwindi.

Ana osakwana zaka 10 salembetsedwa mankhwala chifukwa choopsa chotenga myopathy ndi rhabdomyolysis yama cell minofu.

Malangizo ogwiritsira ntchito

Zokor amatengedwa kamodzi patsiku. Izi zimachitika bwino nthawi yogona. Piritsi silingathe kutafunidwa, koma imayenera kumeza yonse, ndikutsukidwa ndi madzi okwanira.

Asanayambe mankhwala a statin, wodwalayo ayenera kudya zakudya za cholesterol kwa miyezi iwiri. Zakudyazo ziyenera kutsagana ndi maphunziro onse a Zokor.

Dotolo amasankha mankhwalawo mosamalitsa kwa wodwala aliyense, molingana ndi mawonekedwe a thupi, chikhalidwe cha matenda ndi kuchuluka kwake, ndipo amatha kuyambira 5 mg mpaka 80 mg patsiku. Mutha kuonjezera tsiku ndi tsiku mlingo wa mankhwalawo osapitilira milungu 4 mutamwa mapiritsi. Kupitilira 80.0 mg ya kakhazikitsidwa ka simvastatin patsiku sikumalandira odwala.

Yambitsani maphunziro a mankhwalawa ndi 5 mg, 10 kapena 20 mg. Kuikidwa koyambirira kumadalira zamatsenga ndi zizindikiro za mbiri ya lipid:

• Chithandizo cha hypercholesterolemia ziyenera kuyamba ndi kuchuluka kwa 10 mg. Munthawi ya chithandizo, mlingo ungathe kuwonjezeka (pang'onopang'ono), mpaka muyeso wololedwa wambiri patsiku - pa 80 milligrams.
• Pofuna kupewa matenda a mtima ndi hyperlipidemia kapena dyslipidemia, mlingo wa 40 mg ungathe kutumikiridwa.
• Zochizira homozygous genercholesterolemia, dokotala amakupatsani mlingo wa 40 mg. Ngati palibe mankhwala, ndiye kuti patatha mwezi umodzi, mankhwala a 80 mg akhazikitsidwa. Mlingo umagawidwa mu 40 mg wa 40 mg ndi kumwa pamlingo womwewo.
• Odwala okalamba safunika kusintha kuchuluka kwa mapiritsi. Palibenso chifukwa china chosinthira ndi kusintha kwa matenda a impso.
• Ana ochokera wazaka 10 zakubadwa ndi hypercholesterolemia ya homozygous, dokotala amakupatsani mlingo wa 10 mg patsiku. Kwa ana ochepera zaka 18, mlingo wa mankhwala ochizira umatha kuwonjezeredwa mpaka 40 milligrams patsiku. Mlingo wa 80 mg paubwana sichikusankhidwa.

Zotheka zoyipa ndi bongo

Mitundu ya mibadwo yoyamba imaloledwa bwino ndi thupi, nthawi zambiri mavuto amabwera pakumwa mankhwala ndi kuchuluka kwa 40 mg, kapena mukamwa mankhwala okhala ndi mlingo waukulu patsiku - 80 mg.

Osapitirira 10% ya odwala amakhudzidwa ndimomwe amamwa mankhwalawa:

• kukula kwa magazi m'thupi,
• kutaya tsitsi
• khungu dermatomyositis,
• chizungulire, migraine,
• dyspepsia
• jaundice wa etiology yazakudya,
• myalgia ndi myopathy,
• kukokana
• pachimake kapamba
• miyendo paresthesia,
• neuropathy yamadipatimenti oyipitsa,
• khalokuz
• urticaria ndi kuyabwa.

Zizindikiro zochepa:

• kupuma movutikira
• kutupa kwa ziwalo zotumphukira,
• arthralgia
• kutopa
• thrombocytopenia
• kuchuluka kwa ESR,
• kusabala kwa amuna.

Zizindikiro zokhazo zomwe zimapangitsa thupi kutembenuka,

• kuchuluka kwa phosphokinase enzyme,
• kuchuluka kwa cholembera phosphokinase index,
• kuchuluka kwakukulu kwa index ya transaminase m'maselo a chiwindi.

Pankhani ya bongo, mankhwala othandizira ndi mawonekedwe a m'mimba amagwiritsidwa ntchito. Njira ya hemodialysis siyothandiza.

Odwala onse ayenera kudziwitsidwa za kuthekera kotukuka kwa minofu pathologies musanatenge. Muyenera kutsatira izi:

• ndi kupweteka kulikonse m'matumbo kapena mafupa, wodwalayo ayenera kuwona dokotala. Nthawi zambiri, kutenga Zokor kumayambitsa kufooka kwa minofu,
• Mankhwala ndi mapiritsi mu 20 mg kapena 40 mg yogwira ntchito, kuyang'anira ntchito za creatine phosphokinase m'magazi, komanso ntchito ya impso, ndikofunikira.
  

Kuwonjezeka kwa indexine ya creatine phosphokinase ndi chizindikiritso cha myopathy mu minofu. Mankhwalawa ayenera kuyimitsidwa kapena kuti mankhwalawo asinthidwe kukhala ochepa ovomerezeka.

Ndemanga za madokotala ndi odwala

Ndemanga za Zokora ndizabwino. Odwala onse ndi madokotala amadziwa kuchuluka kwa mankhwalawa:

Zokor wa hypolipidemic ndi othandiza pazigawo zilizonse za matenda a lipid metabolism m'thupi. Kuphatikiza apo, imagwiritsidwa ntchito ngati prophylaxis yovuta kwambiri kwa matenda a hematopoietic ndi mtima, komanso pamlingo wochira pambuyo pa stroke yapitayi ndi kugunda kwa mtima, komanso pagawo la postoperative kuchira.

Malangizo apadera

Monga mankhwala ena - zoletsa za GM-CoA reductase, Zokor ikhoza kuyambitsa chitukuko myopathies. Nthawi zina zimadziwulula mu mawonekedwe rhabdomyolysis, yomwe nthawi zina imayendera limodzi ndi kulephera kwaimpso.

Pewani mgwirizano wa Zokor ndi mankhwala osokoneza bongo, omwe, atatengedwa nthawi yomweyo, angayambitse chiwonetsero cha myopathy.

Odwala onse omwe adalembedwa Zocor ayenera kuchenjezedwa za mwayi wowonekera. myopathiesndi kufunikira, mutatha kupanga woyamba wa matendawa, funsani dokotala nthawi yomweyo. Pokayikira koyamba kwa chitukuko cha myopathy, chithandizo chiyenera kuyimitsidwa.

Mwa odwala ena omwe adalandira Zokor, kuwonjezeka kwa kuchuluka kwa michere ya chiwindi kumadziwika. Pambuyo pakuyimitsidwa kwa chithandizo, zizindikirazo zimabwereranso pang'ono pang'onopang'ono.

Musanayambe maphunziro, ndikofunikira kuchita kafukufuku wa chiwindi. Phunziroli liyenera kubwerezedwa musanachulukitse mlingo wa simvastatin kuti ikhale yokwanira tsiku lililonse.

Ndi kulephera kwapakati kwakhungu, wodwalayo safunika kuchepetsa mlingo wa mankhwalawo. Kulephera kwambiri kwa aimpso, mlingo wopitilira 10 mg ukhoza kutumikiridwa pokhapokha kuvomerezedwa ndi adokotala.

Migwirizano ndi magwiritsidwe akusungidwa

Moyo wa alumali wa mankhwalawa kuyambira nthawi yomwe amapanga ndi zaka ziwiri.

Mapiritsiwa ayenera kusungidwa koyambirira matenthedwe pamtunda osapitirira + 25-30⁰, m'malo opanda khungu ndi owuma osafikirika ndi ana.

Mankhwala Zokor Forte ndi mankhwala okha.

Mtengo wapakati m'mafakitala aku Russia zimakhala ma ruble 450-500 (phukusi lomwe lili ndi mapiritsi 14) ndi ma ruble 700-750 (mapiritsi 28)

Mankhwala ku Ukraine perekani kuti mugule mankhwalawa pamtengo wa 150 mpaka 500 hryvnia, kutengera kuchuluka kwa mapiritsi mum paketi.

Mankhwala amakono amapereka machitidwe angapo a Zokora Forte, omwe ali ndi chinthu chofanana ndipo ali ndi mphamvu yopanga tanthauzo.

Mukamasankha wogwirizira, ndibwino kukaonana ndi dokotala.

Ma analogi odziwika kwambiri a mapiritsi a Zocor Forte ndi awa:

Mankhwala Zokor Forte amayenera kuwunikiridwa bwino kwambiri chifukwa adilesi yake imagwiritsidwa ntchito mosavuta.

Odwala ambiri omwe adagwiritsa ntchito ntchito ya prophylactic ndi achire, adawona kuchepa kwa cholesterol, komanso chidwi chachikulu pa mtima wamtima.

Pamapeto pa nkhaniyi, mutha kupeza ndemanga zatsatanetsatane zopita kwa mankhwalawa. Ndipo ngati muli ndi chidziwitso chakugwiritsa ntchito mapiritsi a Zokor Forte, onetsetsani kuti mukugawana malingaliro anu ndi alendo ena omwe amabwera tsambalo.

Zomwe muyenera kuganizira musanatenge mapiritsi a Zocor Forte?

1. Mankhwala Zokor Forte, omwe amaperekedwa mwanjira ya mapiritsi, amawongolera pofuna kuchiza ndi kupewa matenda a mtima, komanso atherosulinosis.
2. Mlingo wovomerezeka tsiku lililonse ndi 80 mg.
3. Ndi koletsedwa kumwa mankhwala pa nthawi ya pakati ndi mkaka wa m`mawere, matenda owopsa a chiwindi, komanso ngati pali vuto lililonse pazamankhwala.
4. Pa nthawi ya mankhwalawa, zakumwa zoledzeretsa siziyenera kusiyidwa ndi chakudya.
5. Njira ya mankhwala yomwe adokotala adapereka sayenera kupitilira.

Malangizo ndi kugwiritsa ntchito Zokor: analogues, ndemanga, kapangidwe, mtengo

Lekarstva.Guru> Z> Malangizo ndi kugwiritsa ntchito Zokor: analogues, ndemanga, mawonekedwe, mtengo

Zokor forte ndi mankhwala omwe amalepheretsa kukula kwa matenda a mtima. Sizingochepetsa kuchuluka kwa cholesterol yoyipa m'magazi a wodwalayo, komanso kukula kwa cholesterol yonse bwino. Chifukwa cha mphamvu zake zamatsenga, Zokor imachepetsa kufa kwathunthu kwa odwala ndi 30%! Ndipo odwala odwala matenda ashuga, chiwopsezo cha zovuta za m'magazi chimachepetsedwa ndi 55%!

• Zokor - ndi chiyani?
• Kutulutsa Fomu
• Zizindikiro zogwiritsidwa ntchito
• Contraindication
• Malangizo ogwiritsira ntchito, mlingo
• Zotsatira zoyipa

Zokor - ndi chiyani?

Zokor ndi mankhwala omwe amapezeka kuti amapanga milid. Imapezeka ndi nayonso mphamvu kuchokera ku Aspergillus terreus. The yogwira mankhwala Zokor forte - simvastatin.

Ichi ndi lactone chosagwira, kulowa mkati mwa hydrolysis, amapanga hydroxy-acid exivative yolingana. Iyo, ndi metabolite yomwe imalepheretsa HMG-CoA.

HMG-CoA ndi reductase, kapena enzyme yomwe imatha kulimbikitsa kuthamanga ndi kuthamanga kwa magawo a cholesterol biosynthesis m'thupi la munthu.

HMG-CoA, ndikusintha mevalonate, ndiye gawo loyamba la cholesterol biosynthesis. Chifukwa chake, kugwiritsidwa ntchito kwa Zokor forte sikuti kumapangitsa kuti pakhale poizoni poizoni m'thupi.

Izi zikutsimikiziridwa ndi maphunziro omwe adachitika ku UK kwa zaka 5 ndi miyezi isanu.

Kuphatikiza pa zonsezi pamwambapa, HMG-CoA imatha kusinthidwa kukhala Co-A, enzyme yomwe imagwira nawo ntchito zambiri zamitundu yosiyanasiyana.

Tiyenera kudziwa kuti maphunziro ambiri amatsimikiziranso - mankhwala a Zokor chimodzimodzi kwa odwala onse. Kuchita bwino sikudalira msinkhu, jenda, kuchuluka kwa cholesterol kapena kusakhalapo / kukhalapo kwa mankhwala ofanana.

Ngati mukukayikira chithandizo chomwe muli nacho, kuwunika pa intaneti kungakuthandizeni kuyesa zabwino ndi zoipa zilizonse za chithandizo chotere.

Malangizo ogwiritsira ntchito, mlingo

Malinga ndi malangizo, musanayambe kugwiritsa ntchito mankhwala a Zokor forte, wodwalayo ayenera kuikidwa zakudya zama hypocholesterol. Ndikofunikira kutsatira zakudya zotere panthawi yonseyi.

Mlingo wovomerezeka womwe umawonetsedwa mu malangizo ndi wochokera pa 5 mg mpaka 8 mg. Ndikofunikira kugwiritsa ntchito mankhwalawa madzulo, kamodzi patsiku. Munthawi yosankha mulingo woyenera wa mankhwalawa, nthawi iyenera kuchitika: muyenera kusintha kuchuluka kwa tsiku lililonse la Zocor osapitilira 1 nthawi m'milungu inayi. Kuchuluka kovomerezeka kwa Zokor forte patsiku ndi 80 mg.

Makamaka chidwi ndi kusintha kwa mlingo uyenera kuperekedwa kwa odwala omwe ali ndi matenda am'mitsempha kapena matenda oopsa. Mlingo wovomerezeka tsiku lililonse, kwa odwala, ndi wotsika kwambiri - 40 mg. Imwani mankhwalawa 1 nthawi patsiku, madzulo.

Kutsatira malangizowo mankhwalawa aphatikizidwe ndi zakudya zapadera komanso mankhwala othandizira odwala:

• Ndi matenda a mtima a ischemic kapena chiopsezo chotenga matenda a mtima a ischemic,
• Matenda a shuga
• Mbiri yakale ya matenda amisala
• kukhala ndi matenda otumphukira.

Odwala omwe ali ndi hypercholesterolemia omwe sakuphatikizidwa pamndandanda omwe ali pamwambapa amapatsidwa mlingo wosiyananso. Mlingo woyambirira pankhaniyi ndi 20 mg. Imwani mankhwala kamodzi patsiku, madzulo.

Kwa iwo omwe chithandizo chawo chimaphatikizapo kuchepa kwakukulu m'magulu a LDL, mlingo woyambayo umakulitsidwa mpaka 40 mg. Ngati wodwala ali ndi hypercholesterolemia, ndiye kuti kuchuluka kwa mankhwalawo ndi 10 mg.

Kusankhidwa kwa mlingo kuyenera kuchitika malinga ndi malangizo, ndikuwonetsa nthawi yomwe angasinthe.

Homositic mabanja a hypercholesterolemia imapereka mitundu iwiri yolandila. Choyamba: mankhwalawa amatengedwa nthawi 1 patsiku, madzulo, kuchuluka kwa 40 mg. Chachiwiri: 80 mg ya mankhwalawa amagawidwa pawiri.

Milandu yogwiritsira ntchito iyi imagwiritsidwa ntchito ngati chithandizo china, chokhudza kuchepa kwakukulu kwa cholesterol, sichikugwira ntchito pamenepa. Kapena Zokor imagwiritsidwa ntchito ngati adjunctive tiba.

Ngati wodwala atenga ma fibrate, mlingo woyenera umasinthidwa payekha kuchokera kwa odwalawo, kutengera ndi mafupa omwe adayikidwa.

Popeza kulephera kwa impso ndi kuphwanya kwambiri chithandizo cha mankhwala a Zokor forte, nthawi zambiri amayesa m'malo mwake ndi analogues.

Koma ngati njirayi ndiyosavomerezeka, ndikofunikira kupereka zovuta zonse zotheka ndikuwona kuti ngati wodwalayo akuyenera kugwiritsa ntchito Zokor forte.

Komabe, ngati wodwalayo alephera kulephera, alembe Mlingo wa mankhwalawo sasintha. Popeza munthawi yaying'ono, koma njira yothetsera vutoli imakhudzanso impso.

Zotsatira zoyipa

Malinga ndi kafukufuku, chiopsezo cha mavuto pambuyo kutsatira Zokor forte ndi 2% yokha. Pachifukwa ichi, kulandira chithandizo ndi mapiritsi a Zokor ndikofunikira makamaka kwa analogi. Kuphatikiza apo, mitengo yamitengo yamalonda siyapamwamba. Mtengo wapakati wa mankhwalawa ku Ukraine ndi wochokera ku 15 mpaka 30 UAH. Mtengo wamba ku Russia ndi 400 mpaka 700 rubles.

Asanayambe kugwiritsa ntchito mankhwalawa muzochitika zamankhwala, 1% inali milandu zoterengati:

Zotsatira zinaomwe amagwiritsidwa ntchito ndi mankhwalawa omwe amapezeka mu 0.5-0.9% ya milandu:

Pali umboni wa milandu yapafupipafupi ya myopathy.

Maonekedwe amtunduwu ndizothekanso:

• Chizungulire
• Kuchepetsa mseru
• Hepatitis
• Kutsegula m'mimba
• Pancreatitis
• Kubweza
• Jaundice
• Peripheral neuropathy,
• Khalidkalil,
• Myalgia
• Dermatomyositis
• Kuyabwa
• Zotupa pakhungu
• Minofu kukokana
• Zofooka zambiri
• Anemia

Kafukufuku wa Laborator ndi zaka zambiri zochita sanawonetse mavuto aliwonse obwera chifukwa cha odwala ambiri. Mulingo wokhazikika wa mankhwalawa ndi 3.6 g .Mankhwala osokoneza bongo, wodwala amapatsidwa chithandizo choyenera komanso chothandizira.

Musanayambe chithandizo, ndikofunikira kusanthula bwino ntchito ya impso. Phunziro lotere liyenera kubwerezedwa musanayambe kuchuluka kwa mankhwalawa.

Odwala omwe amamwa mankhwalawa, kusintha pamlingo wa hepatic michere kunadziwika. Komabe, atamaliza maphunzirowo, maphunzirowo pang'onopang'ono abwerera mwakale.

Ngati wodwala ali ndi vuto lalikulu la kulephera kwa impso, kuwonjezeka kwazinthu zazikulu (10 mg) kumachitika pokhapokha kukaonana ndi chilolezo cha katswiri.

Kufotokozera za mankhwala Zocor

Ndinaopa kuvomera kulandira chithandizo, koma adotolo adalimbikira, nati kwa ine, chithandizo china sichingakhale chothandiza. Mwamwayi, adanditsimikizira kuti ndayamba kale kukonza.

Milena, Kharkov

Ndinalephera pang'ono ndi impso komanso mafuta ambiri. Ndinavomera kulandira mankhwala a Zokor. Kwa nthawi yayitali mlingo wovomerezeka unasankhidwa, koma izi ndizopusitsa, chachikulu ndichakuti matendawa amabwerera m'mbuyo. Wokondwa ndidavomera.

Alexander, Minsk

Moona mtima, sindine katswiri wa mankhwala, adotolo adati - izi zikutanthauza kuti tikuyenera kuvomereza. Chachikulu ndikupeza katswiri woyenera yemwe mumamukhulupirira, ndiye kuti chithandizo chilichonse chikhala bwino. Pazonse, zokumana nazo zanga ndizabwino.

Svetlana Oryol

Zokor: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi fanizo

Mankhwala a hypolipidemic Zokor amagwiritsidwa ntchito kutsitsa cholesterol ya magazi mu hypercholesterolemia. Zokor ndi choletsa wa HMG-CoA reductase ndipo ali m'gulu la ma pharmacological a statins. Munkhaniyi tikambirana za momwe angagwiritsire ntchito mankhwala Zokor, zikuonetsa ndi zotsutsana, mayendedwe ndi malingaliro.

Mafomu a pharmacological

Wopanga amatulutsa mankhwalawo ngati mawonekedwe a piritsi. Mapiritsi okhala ndi mulingo wa 10 mg wa chophatikizacho ali ndi mtundu wa pinki wopepuka, mawonekedwe osalala mbali imodzi, ndipo kujambula kumakhala mbali inayo.

Mapiritsi a Zokor okhala ndi muyezo wa 20 mg simvastatin ali ndi mtundu wachikasu, mtundu wowoneka bwino mbali inayo, ndipo cholembera chili mbali inayo.

Mapiritsi okhala ndi mulingo wa simvastatin 40 mg (Zokor Forte) ali ndi mtundu wa pinki, mawonekedwe osalala mbali imodzi, ndipo kujambula kumakhala mbali inayo.

Atanyamula mapiritsi m'matumba a 14 zidutswa. Makatoni aliwonse amakhala ndi matuza 1 kapena 2.

Izi zimatsimikiziridwa ndi malangizo ogwiritsa ntchito. Analogs of Zokor adzawonetsedwa pansipa.

Zizindikiro zogwiritsidwa ntchito

Mankhwala tikulimbikitsidwa kuti azigwiritsidwa ntchito ndi odwala omwe ali pachiwopsezo cha matenda a mtima. Komanso omwe ali pachiwopsezo akuphatikiza anthu omwe ali ndi ma pathologies monga:

1. Matenda amafooketsedwa.
2. Matenda a shuga.
3. Cerebrovascular matenda.

Mankhwalawa angagwiritsidwe ntchito pochiza odwala omwe ali ndi vuto la mtima la ischemic, hypercholesterolemia. Potere, zimathandizira kupewa ma atherosselotic pathologies a mtima ndi mitsempha yamagazi.

Mndandanda wazomwe zikugwiritsidwa ntchito ngati mankhwalawa "Zokor" ndiwotsatsa chidwi.

Itha kulimbikitsidwanso kuti mugwiritse ntchito pazotsatirazi:

1. Homozygous mtundu wa hypercholesterolemia (kuphatikizapo mankhwala othandizira, njira zina).
2. Cholesterol yotsika kwambiri ya lipoprotein yapamwamba kwambiri yokhudzana ndi hypercholesterolemia yoyambirira yochokera pakudya.
3. Hypertriglyceridemia.
4. Miyezi yambiri ya apolipoprotein B, cholesterol yathunthu (kuphatikiza mankhwala othandizira).

Zotsatira zoyipa

Malinga ndi malangizo ogwiritsira ntchito ndi kuwunika kwa "Zokor", zizindikiro zotsatirazi zingayambike mwa wodwala panthawi ya chithandizo:

1. Arthralgia, ESR yowonjezera, nyamakazi, eosinophilia, thrombocytopenia, dermatomyositis, vasculitis, angioedema.
2. Kuchepa kwa chiwindi, rhabdomyolysis, myopathy.
3. Kuyenda, alopecia, zotupa.
4. Kuphwanya kugona, kukumbukira, paresthesia, zotumphukira zamitsempha, kukoka, chizungulire.
5. Matendawa, kufooka, mutu.
6. Defecation matenda, thukuta, kupweteka kwam'mimba, kusapeza pamimba.

Mwambiri, mankhwalawa amalekeredwa bwino ndi odwala.

Kugwiritsa ntchito mankhwala

Imwani mankhwala "Zokor" pakamwa, osatchula chakudya. Wapakati tsiku ndi tsiku la mankhwalawa ndi 5-80 mg. 80 mg - mlingo woyenera wovomerezeka wa simvastatin, womwe ungatengedwe masana.

Mlingo amasankhidwa ndi katswiri aliyense payekhapayekha. Chifukwa chake, pofuna kuchiza komanso kupewa matenda a mtima wapamtima kuphatikiza ndi chithandizo cha zakudya, akuwonetsa kutenga 40 mg ya Zokora patsiku.

Pofuna kuthana ndi hypercholesterolemia, akuwonetsa kutenga 20 mg ya Zokor patsiku.

Zokhudza chiwindi

Kafukufuku wachipatala kwa odwala akuluakulu omwe amalandila simvastatin apeza kuwonjezeka kwamlingo wa michere ya chiwindi. Ndi kutha kapena kusokonezeka kwa mankhwala, zochitika za ma transaminases nthawi zambiri zimabwereranso ku mtengo wawo woyambirira. Izi sizimayenderana ndi jaundice kapena zizindikiro zina zamankhwala, koma zimatha kuwonetsa kupatuka pazotsatira zoyeserera zamagulu a chiwindi ndi / kapena kumwa mowa usanayambe mankhwala. Hypersensitivity zimachitika sizinapezeke.

Phukusi la mapiritsi 28 a Zokora omwe ali ndi Mlingo wa 20 mg adzafunika ma ruble 750, ndi mlingo wa 40 mg - 500 rubles. Zimatengera dera komanso maukonde opangira mankhwala.

Analogs of Zokora

Ngati ndi kotheka, Zokor ikhoza m'malo mwa imodzi mwazokonzekera izi: Simvor, Zovatin, Simgal, Vabadin, Levomir, Aterostat, Simlo, Simvakard, Avestatin, Simvastatin, Akorta, Pravastatin, Simvastol, Ariescor, Simgal, Lovastatin, Lipitor, Liptonorm, Rosulip, Rosart, Tevastor, Atomax , Liprimar, Atoris, Rosucard, Vasilip, Roxer, Rosuvastatin, Tulip, Krestor.

Zotsatira za mankhwalawa ndizofanana, kufunika kogwiritsa ntchito mankhwala ena mwanjira iliyonse kuyenera kutsimikiziridwa ndi dokotala.

"Krestor" ndi amodzi mwa fanizo la "Zokor". Chosakaniza chophatikizika mu kapangidwe kake ndi calcium rosuvastatin. Zowonjezera ndi: magnesium stearate, glycerol triacetate, E172, E171, hypromellose, calcium phosphate, lactose monohydrate, crospovidone, cellcrystalline cellulose.

Wopanga "Crestor" akupezeka mu mawonekedwe apiritsi. Piritsi lililonse limakhala ndi 5, 10, 20, 40 mg yogwira ntchito. Monga Zokor, Krestor ndi mankhwala ochepetsa lipid.

Zomwe zili bwino - "Zokor" kapena "Crestor" ndizovuta kuzithetsa.

Zizindikiro zazikulu zakugwiritsira ntchito kwake ndi:

1. Kupewa kwa chitukuko cha mtima.
2. Atherosulinosis
3. Hypercholesterolemia yosakanikirana (monga gawo la zovuta mankhwala pamodzi ndi kuwonda, zolimbitsa thupi, zakudya mankhwala).
4. Kupewa, chithandizo cha mabanja hypercholesterolemia.

"Crestor" imakhudzana ndi kukhalapo kwa thupi, zochitika zaumoyo monga:

1. Kutenga gawo lililonse la mankhwala.
2. Zaka mpaka 18.
3. Myopathy
4. Chithandizo cha mankhwala a cyclosporin.
5. Mimba, nthawi yotsatsa.
6. Mitundu yambiri ya hepatic pathologies, makamaka, yolumikizana ndi kuchuluka kwa transaminases m'magazi.

Kutengera zakumayambiriro kwa kugwiritsa ntchito mankhwalawa, zoyipa monga:

1. Tubular proteinuria.
2. Asthenia.
3. Kutsekula m'mimba, kudzimbidwa, kapamba, nseru.
4. Mayankho oyipa.
5. Myopathy
6. Polyneuropathy, mutu.

Tengani "Crestor" ayenera kukhala pakamwa, kwathunthu, kupewa kutafuna. Ndikulimbikitsidwa kuti ndiyambe kugwiritsa ntchito mankhwala osokoneza bongo ndi mlingo woyambirira wa 5 mg, patatha milungu itatu adokotala azindikire kufunikira kokulimbikitsa kuchuluka kwa 20 kapena 40 mg kutengera thanzi la wodwalayo.

Odwala nthawi zambiri amafunsa kuti ndi mankhwala ati, Zokor kapena Krestor, omwe amaposa. Yankho la funsoli silingafanane. Choyamba, chosakaniza chogwira chimakhazikitsidwa pazosakaniza zingapo zogwira ntchito. Kachiwiri, thupi la munthu aliyense ndi la munthu payekha: mankhwala ogwirira ntchito kwa wodwala m'modzi sangakhale oyenera kwa wodwala wina. Ichi ndichifukwa chake katswiri ayenera kusankha mankhwala oyenera kwambiri.

Simvastatin

"Simvastatin" ndi analogue ya "Zokor" malinga ndi gawo lomwe limagwira, limatengera simvastatin. Pomwe zinthu zothandiza zimagwiritsidwa ntchito: butylhydroxyanisole, macrogol, talc, hypromellose, ascorbic acid, starch ya chimanga, lactose, povidone, citric acid, titanium dioxide, calcium stearate.

Wopanga "Simvastatin" amapezeka mu mawonekedwe a mapiritsi, amaikidwa mu matuza kapena zitini za pulasitiki ya polymer ndikukhala ndi mulingo wa yogwira 10, 20, 40, 80 mg.

Zina mwa zomwe zikugwiritsidwa ntchito ndi Simvastatin ndi izi:

1. Kupewa kwa kupitirira kwa atherosulinosis.
2. Kupewera kwa kanthawi kochepa kugunda kwa ischemic, stroke.
3. Kupewa kwa myocardial infarction.
4. Wophatikiza mtundu wa hypercholesterolemia, hypertriglyceridemia (ngati zochitika zolimbitsa thupi zokwanira komanso zamankhwala sizothandiza).
5. Hypercholesterolemia ya pulayimale (ngati palibe njira zochiritsira zosagwiritsidwa ntchito ndi mankhwalawa komanso mankhwala othandizira zakudya) mwa odwala omwe ali pachiwopsezo chotenga atherosulinosis.

"Simvastatin" imatsimikiziridwa kuti igwiritse ntchito ngati wodwala ali ndi matenda, thupi:

1. Zaka mpaka 18.
2. Matenda a chiwindi.
3. Kutengeka kwamunthu payekha pazinthu za mankhwala.
4. Kuchulukitsa AST, ALT.
5. Myopathy, mafupa ena a minofu.

Pazinthu zina zokhudzana ndi zovuta zomwe zimagwiritsidwa ntchito popanga mankhwala:

1. Zochita za opaleshoni, zovulala.
2. Khunyu
3. Matenda a metabolism.
4. Zolemba zotchulidwa za endocrine system.
5. Kusavomerezeka ndi madzi-electrolyte.
6. Matenda ogwirizana.
7. Mowa
8. Kukonzanso nthawi pambuyo kupatsidwa chiwalo, immunosuppressation.

Kugwiritsidwa ntchito kwa "Simvastatin" kungasokoneze mkhalidwe wa wodwalayo, ndikupangitsa kuti zinthu zoyipa monga:

1. Matumbo, palpitations, pachimake mitundu yaimpso kulephera, kukwiya ndi rhabdomyolysis, utachepa potency.
2. Alopecia, pruritus, dermatomyositis.
3. Myalgia, rhabdomyolysis, kufooka kwambiri, myopathy, minofu kukokana.
4. Kufupika, nyamakazi, kunyeguka pakhungu, kuchuluka kwa ESR, malungo, urticaria, photosensitivity, lupus-like syndrome, eosinophilia, polymyalgia rheumatica, thrombocytopenia, angioedema.
5. Peripheral neuropathy.
6. Kusowa tulo, minyewa kukokana, kusokonezeka kwa chisangalalo, chizungulire, paresthesia, asthenic syndrome, migraine, kuwona kwamaso.
7. Kuchepetsa msana, matenda am'mimba, kusanza, kuchuluka kwa AST, ALT, CPK, kudzimbidwa, kupweteka kwa epigastric, flatulence, kapamba.

Kugwiritsa ntchito "Simvastatin" kuyenera kuyambitsidwa ndi osachepera Mlingo, ndikuwonjezera iwo pang'onopang'ono mwezi uliwonse. Ndi bwino kugwiritsa ntchito mankhwalawa kamodzi patsiku, pogona, mutamwa piritsi limodzi. Mlingo watsimikiza ndi dokotala potengera momwe wodwalayo alili. Monga lamulo, mphamvu ya mankhwalawa imawonedwa mukamagwiritsa ntchito 20 mg ya mankhwala patsiku.

Mtengo wapakati wa phukusi la Simvastatin ndi ma ruble 400.

Simgal ndi analogue ya Zokor malinga ndi gawo lomwe limagwira. Muli simvastatin. Zowonjezera zake ndi: lactose monohydrate, microcellulose, magnesium stearate, citric acid monohydrate, pregelatinized wowuma, butyl hydroxyanisole, ascorbic acid.

Wopanga "Simgal" akupezeka mu mawonekedwe a piritsi, mapiritsi amatha kukhala ndi muyeso wa simvastatin 10, 20, 40 mg.

Zizindikiro zazikulu pakugwiritsa ntchito Simgal:

1. Kupewa kwa CCC pathologies kwa odwala omwe ali ndi matenda a shuga, atherosclerosis.
2. Therapy ya hypercholesterolemia (pulayimale, cholowa homozygous).
3. Chithandizo cha dyslipidemia wosakanikirana.

Simgal imatsutsana pamilandu yotsatirayi:

1. Chithandizo cha mankhwala omwe ali ndi mankhwala oletsa cytochrome CYP3A4 (Nefazodon, Telithromycin, Itraconazole, Nelfinar, Clarithromycin, Erythromycin).
2. Nthawi yotsekera, mimba.
3. Zokwera milingo yama transaminase.
4. Kuchulukitsa kwa hepatic pathologies.
5. Kuchulukana kwina kwamphamvu zomwe zimapangidwira pama mankhwala.

Potengera momwe ntchito ya "Simgal" ikuyambira, zingachitike zotsatirazi zotsatirazi:

1. Kuchuluka kwa zamchere phosphatase, transaminases.
2. Kufooka, kupuma movutikira, eosinophilia, photosensitivity, thrombocytopenia, polymyalgia wa mtundu wamatsitsi, nyamakazi, vasculitis, angioedema.
3. Asthenia, myositis, minyewa yam'mimba, myopathy.
4. Alopecia, kuyabwa, zidzolo, jaundice, hepatitis.
5. Pancreatitis, kupweteka m'mimba, kusanza, kukhumudwa.
6. Peripheral polyneuropathy, kupsinjika, chizungulire, paresthesia, kupweteka mutu, kuchepa magazi.
7. Kugonana, kukhumudwa, kusokonezeka kukumbukira, kugona.

Ndikulimbikitsidwa kutenga Simgal kamodzi patsiku kwa 10-20 mg. Nthawi zina, mogwirizana ndi katswiri, kuchuluka kwa tsiku lililonse mpaka 80 mg ndikuloledwa. Ngati pakufunika, piritsi limatha kugawidwa m'magawo angapo. Mlingo weniweni wa mankhwalawa uyenera kutsimikiziridwa ndi dokotala.

Ndemanga pa Zokor

Mankhwalawa ndi mawonekedwe ake amadziwika ndi odwala ngati njira yothandiza kwambiri yolepheretsera matenda a CVS ndi chithandizo cha hypercholesterolemia. Kugwiritsa ntchito mankhwalawa kumadziwika padera, nthawi zambiri madokotala amalimbikitsa kumwa kamodzi patsiku la mankhwalawa, zomwe zimathandizira wodwala kugwiritsa ntchito mankhwalawa.

Tidawunikiranso malangizo omwe angagwiritsidwe ntchito ndi Zokor, ndemanga, komanso fanizo zake.

Mlingo ndi makonzedwe

Asanayambe komanso kuthandizira, ayenera kudya zakudya za hypocholesterol. Mkati, pa koyamba mlingo wa 10 mg kamodzi, madzulo, modekha kapena modekha hypercholesterolemia, mlingo woyambirira ndi 5 mg, ngati kuli kotheka, mlingo umakulitsidwa pang'onopang'ono pakadutsa masabata anayi. Ndi banja homozygous hypercholesterolemia, tsiku ndi tsiku 40 mg kamodzi, madzulo kapena 80 mg / tsiku (logawidwa 3 Mlingo - 20 mg m'mawa, 20 mg masanawa, 40 mg madzulo). Ndi matenda a mtima a mtima, mlingo woyambirira ndi 20 mg, kamodzi, madzulo, ngati kuli kofunikira, amawonjezedwa pang'onopang'ono pakadutsa masabata anayi mpaka 80 mg.

Njira zopewera kupewa ngozi

Musanayambe chithandizo, ndikofunikira kuchita (kenako ndikubwereza) kafukufuku wama chiwindi. Mulingo wa transaminases ukayamba kupitirira malire amtunda ndi katatu, mankhwalawo amaletsedwa. Amalembedwa mosamala kwa odwala omwe amamwa mowa kwambiri / komanso omwe ali ndi mbiri yodwala matenda a chiwindi.

Alumali moyo wa mankhwala Zokor®

10 mg mapiritsi okhala ndi mafilimu - 3 zaka.

makanema okhala ndi filimu 20 mg - 3 zaka.

TACHIMATA mapiritsi 10 mg - 3 zaka.

TACHIMATA mapiritsi 20 mg - 3 zaka.

TACHIMATA mapiritsi 40 mg - 2 zaka.

TACHIMATA mapiritsi 80 mg - 2 zaka.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Malangizo ogwiritsira ntchito Zokora: njira ndi mlingo

Asanayambe kugwiritsa ntchito Zokor, wodwalayo amapatsidwa zakudya zoyenera za hypocholesterol, zomwe zimayenera kuyang'aniridwa panthawi yonse ya chithandizo.

Mlingo wa tsiku ndi tsiku wa mankhwalawa (kuyambira 5 mpaka 80 mg) uyenera kumwa 1 mg umodzi.

Munthawi ya kumwa mankhwala, kuwonjezeka kwake kumachitika osachepera 4 sabata. Mulingo wovomerezeka tsiku lililonse ndi 80 mg.

• Odwala omwe ali ndi matenda amitsempha yamagazi kapena chiwopsezo cha kukula kwake: 40 mg kamodzi patsiku. Mankhwala osokoneza bongo amayamba nthawi yomweyo ndi zakudya komanso masewera olimbitsa thupi,
• Odwala omwe ali ndi hypercholesterolemia (osakhala pachiwopsezo chotenga matenda a mtima): koyamba mlingo - 20 mg patsiku. Nthawi zina (ngati kuchepa kwa LDL woposa 45% kukufunikira), mlingo woyambirira wa 40 mg ukhoza kutumikiridwa. Ndi mtundu wofatsa kwambiri wa hypercholesterolemia, mankhwalawa amatha kuyamba ndi 10 mg wa 10 mg, ngati n`koyenera, mukulitse pang'onopang'ono,
• Odwala omwe ali ndi homozygous achiberekera hypercholesterolemia: 40 mg kamodzi patsiku kapena 80 mg mu 3 mgawani Mlingo - 20 mg m'mawa ndi masana ndi 40 mg madzulo.Pankhaniyi, Zokor itha kutumikiridwa ngati mankhwala amodzi kapena kuwonjezera pa njira ina yothandizira yomwe imatsitsa cholesterol (mwachitsanzo, LDL plasmapheresis).

Zokor imagwiritsidwa ntchito ngati monotherapy kapena kuphatikiza ndi bile acid sequestrants. Pankhaniyi, kusintha kwa mankhwalawa kumafunika malinga ndi mankhwala omwe amagwiritsidwa ntchito nthawi imodzi:

• Danazole, cyclosporine, gemfibrozil, mafupa ena (kupatula fenofibrate), lipid-kutsitsa niacin (> 1000 mg / tsiku): tsiku ndi tsiku la Zokor ndi 10 mg,
• Verapamil, amiodarone: tsiku lililonse sayenera kupitirira 20 mg.

Odwala omwe ali ndi vuto lowona aimpso safunika kusintha mlingo. Odwala omwe amalephera kwambiri aimpso (creatinine chilolezo chochepera 30 ml / miniti) saloledwa kupitilira mlingo wa 10 mg. Ngati kufunikira kotere kuli koyenera, chithandizo chikuyenera kuchitika moyang'aniridwa mosamala ndi madokotala.

Analogs of Zokor

Zofanizira za mankhwalawa ndi mankhwala Simvastatin, Avestatin, Simvakard, Simlo, Atherostat, Levomir, Vabadin, Simgal, Zovatin, Simvor.

Amapereka zofanana, koma katswiri yekha ndi amene ayenera kudziwa mankhwala omwe ali olondola kwambiri.

Palibe chidziwitso chokwanira chogwiritsira ntchito mankhwalawa kwa ana, kotero mankhwalawa sagwiritsidwa ntchito pochiza ana osakwana zaka 10.

Zokor amagwiritsidwa ntchito pofuna kuchiza matenda amtundu wa hypercholesterolemia mwa achinyamata pazakudya. Mothandizidwa ndi mankhwalawa, kuchuluka kwa triglycerides, cholesterol, apolipoprotein B kumachepa.

Kuthandiza atsikana omwe ali ndi mankhwalawa kumachitika pokhapokha ngati msambo mu msungwana wazaka zochepa unayamba chaka chimodzi chatha.

Bongo

Mu milandu ingapo yodziwika bwino ya bongo (450 mg wambiri), palibe zizindikiro kapena zotsatira zake zomwe zapezeka. Mankhwala othandizira amagwiritsidwa ntchito.

Njira zopewera kupewa ngozi

Musanayambe chithandizo, ndikofunikira kuchita (kenako ndikubwereza) kafukufuku wama chiwindi. Mulingo wa transaminases ukayamba kupitirira malire amtunda ndi katatu, mankhwalawo amaletsedwa. Amalembedwa mosamala kwa odwala omwe amamwa mowa kwambiri / komanso omwe ali ndi mbiri yodwala matenda a chiwindi.

Zokor® mankhwala

Kutentha kopitilira 30 ° C.

Pewani kufikira ana.

Alumali moyo wa mankhwala Zokor®

10 mg mapiritsi okhala ndi mafilimu - 3 zaka.

makanema okhala ndi filimu 20 mg - 3 zaka.

TACHIMATA mapiritsi 10 mg - 3 zaka.

TACHIMATA mapiritsi 20 mg - 3 zaka.

TACHIMATA mapiritsi 40 mg - 2 zaka.

TACHIMATA mapiritsi 80 mg - 2 zaka.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Kutulutsa mawonekedwe ndi kapangidwe kake

Amapezeka mu mawonekedwe a mapiritsi okhala ndi zokutira: chowulungika, chosalala mbali imodzi, mbali inayo zolemba "MSD 735" (mapiritsi apinki opepuka) kapena lolemba "MSD 740" (mapiritsi achikasu) (14 ma PC. matuza, 1 kapena matuza awiri pamtundu wa makatoni).

The yogwira ndi simvastatin:

• Piritsi limodzi la kuwala kwa pinki - 10 mg,
• Piritsi limodzi la 1 t - 20 mg.

Omwe amathandizira: ascorbic acid, butylhydroxyanisole, cellcrystalline cellulose, lactose monohydrate, pregelatinized starch, citric acid, magnesium stearate.

Mapangidwe a Shell: hydroxypropyl cellulose, talc, methylhydroxypropyl cellulose, titanium dioxide, utoto wa iron oxide wachikasu ndi iron oxide wofiira.

Zotsatira za pharmacological

Malinga ndi malangizo, Zokor amadziwika ndi zotumphukira zotsikira za lipid. Kuphatikizika kwa mapiritsiwa kumaphatikizapo ntchito yogwira simvastatin, pomwe hydrolyzed, imasandulika kukhala mankhwala othandizira. Metabolite yake imalepheretsa enzyme HMG-CoA reductase, yomwe imakhudzidwa ndi biosynthesis yoyambirira ya cholesterol.

Zotsatira zake, kugwiritsa ntchito mankhwalawa kumathandizira kuchepetsa kuchuluka kwa mafuta m'thupi, komanso kuchuluka kwa cholesterol yolumikizana ndi lipoproteins yotsika komanso yotsika kwambiri. Kuchuluka kwa cholesterol mu plasma ya triglycerides kumachepetsedwa.

Nthawi yomweyo, mukamamwa Zokor, zomwe zimapezeka mu cholesterol yolumikizana ndi lipoproteins yapamwamba zimachuluka kwambiri. Mankhwalawa amagwiritsidwa ntchito pazosiyanasiyana za hyperlipidemia, kuphatikiza osagwirizana ndi banja, banja, heterozygous. Amalembedwanso mitundu yosiyanasiyana ya hyperlipidemia muzochitika ngati mumagwiritsa ntchito chakudya sizingatheke kutulutsa matenda a lipids mu plasma.

Mankhwala a lipasma lipid amachepetsa masiku 14 atatha kukhazikitsidwa kwa mankhwala. Chiwerengero chawo chimafika pang'ono pa sabata la 4 - 6th la mankhwala. Ndi kasamalidwe kena ka mankhwalawa, zotsatira zake zimasungidwa.

Mukamaliza kuthandizira, zisonyezo za cholesterol yathunthu m'madzi a m'magazi zimabweza pang'onopang'ono kwa zomwe zimayambira, zomwe zimatsimikiziridwa mankhwala asanayambe.

Pharmacodynamics ndi pharmacokinetics

Pazitali zambiri za simvastatin metabolites m'magazi zinajambulidwa maola 1.3-2.4 patatha ola limodzi la Zocor. Pafupifupi 85% yazinthu zonse zomwe zimagwiritsidwa ntchito pamapiritsi zimadziwidwa m'thupi ngati zimamwa.

Mukalandira mankhwala, simvastatin yapamwamba imadziwika m'chiwindi kuyerekeza ndi ziwalo zina. Chifukwa cha "gawo loyambirira" la chinthu kudzera m'chiwindi, limapukusidwa, pambuyo pake mankhwala omwewo ndi ma metabolites amachotsedwa m'thupi ndi bile.

Kulandila kwa Zokor sikudalira kugwiritsa ntchito chakudya, zomwe sizikuwakhudza mankhwalawa a pharmacokinetics. Kutalika kwakanthawi kochepa sikupangitsa kuti simvastatin ikhale ndi minofu yambiri m'thupi.

Zizindikiro zogwiritsidwa ntchito

Zocor imalembedwa kwa odwala omwe ali ndi matenda a mtima (CHD) kapena omwe ali ndi vuto la matendawa, komanso kwa odwala omwe ali ndi chiopsezo chokhala ndi matenda a mtima (kuphatikizapo pamaso pa hyperlipidemia), mwachitsanzo, odwala matenda a shuga, odwala matenda opatsirana a mtima, matenda opha ziwalo kapena matenda ena otulutsa ziwalo mu anamnesis. Cholinga cha mankhwalawa:

• Kuchepetsa chiwopsezo cha kufa chifukwa cha matenda amtima,
• Kuchepetsa chiopsezo chokhala ndi zovuta zam'mimba kapena zam'mimba, monga kugwidwa, kuphedwa kwa myocardial, kufa kwa coronary,
• Kuchepetsa chiopsezo chakugonekedwa kuchipatala chifukwa cha ziwopsezo za angina,
• Kuchepetsa mwayi wa kulowererapo kwa opaleshoni chifukwa chofuna kubwezeretsa kutuluka kwa magazi kapena mitundu ina ya kusintha kosagwirizana ndi magazi.

Komanso, pamagulu omwe adatchulidwa odwala, mankhwalawa amadziwitsidwa ngati pakufunika kuchita ntchito ya revascularization.

Kuphatikiza apo, Zokor adalembedwa kuti hypercholesterolemia - monga kuwonjezera pazakudya zomwe zingapangitse kuti pakhale zakudya zopatsa thanzi komanso njira zina zosagwiritsa ntchito mankhwala zosakwanira. Cholinga cha mankhwalawa:

• Chithandizo cha mtundu wa Hyperlipidemia malinga ndi gulu la Fredrickson (hypertriglyceridemia),
• Chithandizo cha hyperlipidemia choyambirira malinga ndi gulu la Fredrickson (dysbetalipoproteinemia),
• Cholesterol okwezeka kwambiri, cholesterol wotsika kwambiri (LDL), apolipoprotein B ndi triglycerides,
• Kuchuluka kwa cholesterol yapamwamba kachulukidwe lipoproteins (HDL) mwa odwala omwe ali ndi hypercholesterolemia, kuphatikiza mtundu IIa hyperlipidemia malinga ndi gulu la Fredrickson (heterozygous Famel hypercholesterolemia) kapena mtundu II hyperlipidemia malinga ndi gulu la Fredrickson (osakanikirana ndi Hypercholestero)
• Kuchepetsa kuchuluka kwa cholesterol yathunthu ku cholesterol ya HDL, komanso LDL cholesterol ku HDL cholesterol,
• Kuchepetsa kuchuluka kwa cholesterol yathunthu, cholesterol ya LDL ndi apolipoprotein B odwala omwe ali ndi homozygous achibale hypercholesterolemia (kuwonjezera pa zakudya ndi zina).

Odwala matenda a shuga, Zokor amachepetsa chiopsezo cha zotumphukira za mtima (kuphatikizapo kupezeka kwa zilonda zam'mimba, kusinthika komanso kudulidwa kwam'munsi kosaletseka).

Odwala omwe ali ndi matenda a mtima, omwe amaphatikizidwa ndi cholesterol yayikulu, mankhwalawa amatha kuchepetsa chiopsezo chokhala ndi matenda a mtima maonekedwe a zovuta ndi kuvulala kwatsopano.

Contraindication

• Kukula kosalekeza pamlingo wa hepatic transaminases mu magazi a plasma osadziwika,
• Matenda a chiwindi,
• Mimba komanso nthawi yakukonzekera kwake,
• Kuchepetsa
• Munthu payekha hypersensitivity pamagawo a mankhwala.

Chifukwa cha kusowa kwa chitetezo chazogwiritsira ntchito simvastatin mu ana, sikulimbikitsidwa kupereka mankhwala kwa ana.

• Mbiri ya rhabdomyolysis,
• Matenda a shuga
• Kuwonjezeka kwamphamvu kwa seramu transaminases (ngati kuchulukitsa kwapamwamba kwambiri nthawi 3, mankhwalawa amachotsedwa),
• Kulephera kwakukulu kwa aimpso (kulengedwa kwa creatinine kosakwana 30 ml / min),
• Mowa.

Malangizo ogwiritsira ntchito Zokora: njira ndi mlingo

Asanayambe kugwiritsa ntchito Zokor, wodwalayo amapatsidwa zakudya zoyenera za hypocholesterol, zomwe zimayenera kuyang'aniridwa panthawi yonse ya chithandizo.

Mlingo wa tsiku ndi tsiku wa mankhwalawa (kuyambira 5 mpaka 80 mg) uyenera kumwa 1 mg umodzi.

Munthawi ya kumwa mankhwala, kuwonjezeka kwake kumachitika osachepera 4 sabata. Mulingo wovomerezeka tsiku lililonse ndi 80 mg.

• Odwala omwe ali ndi matenda amitsempha yamagazi kapena chiwopsezo cha kukula kwake: 40 mg kamodzi patsiku. Mankhwala osokoneza bongo amayamba nthawi yomweyo ndi zakudya komanso masewera olimbitsa thupi,
• Odwala omwe ali ndi hypercholesterolemia (osakhala pachiwopsezo chotenga matenda a mtima): koyamba mlingo - 20 mg patsiku. Nthawi zina (ngati kuchepa kwa LDL woposa 45% kukufunikira), mlingo woyambirira wa 40 mg ukhoza kutumikiridwa. Ndi mtundu wofatsa kwambiri wa hypercholesterolemia, mankhwalawa amatha kuyamba ndi 10 mg wa 10 mg, ngati n`koyenera, mukulitse pang'onopang'ono,
• Odwala omwe ali ndi homozygous achiberekera hypercholesterolemia: 40 mg kamodzi patsiku kapena 80 mg mu 3 mgawani Mlingo - 20 mg m'mawa ndi masana ndi 40 mg madzulo. Pankhaniyi, Zokor itha kutumikiridwa ngati mankhwala amodzi kapena kuwonjezera pa njira ina yothandizira yomwe imatsitsa cholesterol (mwachitsanzo, LDL plasmapheresis).

Zokor imagwiritsidwa ntchito ngati monotherapy kapena kuphatikiza ndi bile acid sequestrants. Pankhaniyi, kusintha kwa mankhwalawa kumafunika malinga ndi mankhwala omwe amagwiritsidwa ntchito nthawi imodzi:

• Danazole, cyclosporine, gemfibrozil, mafupa ena (kupatula fenofibrate), lipid-kutsitsa niacin (> 1000 mg / tsiku): tsiku ndi tsiku la Zokor ndi 10 mg,
• Verapamil, amiodarone: tsiku lililonse sayenera kupitirira 20 mg.

Odwala omwe ali ndi vuto lowona aimpso safunika kusintha mlingo. Odwala omwe amalephera kwambiri aimpso (creatinine chilolezo chochepera 30 ml / miniti) saloledwa kupitilira mlingo wa 10 mg. Ngati kufunikira kotere kuli koyenera, chithandizo chikuyenera kuchitika moyang'aniridwa mosamala ndi madokotala.

Zotsatira zoyipa

• Matumbo ogwiritsa ntchito: dyspepsia (kutsegula m'mimba, kunyansidwa ndi kusanza), kawirikawiri - kapamba, jaundice, hepatitis,
• Pakati mantha dongosolo: vertigo, zotumphukira neuropathy,
• Njira ya minofu ndi mafupa: myalgia, kawirikawiri rhabdomyolysis,
• Thupi lawo siligwirizana ndi immunopathological: lupus ngati matenda, angioedema, polymyalgia rheumatism, kuchuluka ESR, eosinophilia, nyamakazi, thrombocytopenia, arthralgia, vasculitis, urticaria, khungu hyperemia, photosensitivity, kufupika, kutentha
• Dermatological zimachitika: zotupa pakhungu, kuyabwa, dermatomyositis, alopecia,
• Zina: kukokana minofu, paresthesia, malaise, kuchepa magazi,
• Zizindikiro zasayansi: kuchuluka kwama transaminase, alkaline phosphatase ndi gamma-glutamyl transpeptidase, creatine phosphokinase.

Bongo

Pankhani ya mankhwala osokoneza bongo, njira zachikhalidwe zamankhwala zimagwiritsidwa ntchito kuthana ndi zovuta za kuledzera kwa thupi.

Kuyanjana kwa mankhwala osokoneza bongo

Mankhwala otsatirawa omwe amagwiritsidwa ntchito munthawi yomweyo ndi simvastatin (makamaka muyezo waukulu) amawonjezera chiopsezo cha myopathy / rhabdomyolysis:

• Mphamvu zoletsa za CYP3A4: clarithromycin, erythromycin, telithromycin, ketoconazole, nefazodone, itraconazole, human immunodeficiency virusase protease inhibitors,
• Mankhwala ena otsitsa a lipid omwe siopanikizika amphamvu a CYP3A4, koma omwe angayambitse kukula kwa myopathy: gemfibrozil ndi ma fibrate ena (kupatula fenofibrate), niacin (nicotinic acid) mu Mlingo wochepetsa lipid (> 1 g / tsiku),
• Cyclosporin, danazole,
• Amiodarone, verapamil,
• Diltiazem.

Simvastatin, yogwiritsidwa ntchito tsiku ndi tsiku 20 mg mg, imawonjezera mphamvu ya ma coumarin anticoagulants ndikuwonjezera chiopsezo chotaya magazi: nthawi ya prothrombin (International Normalized Ratio) imachulukira kuchokera ku gawo loyambirira la 1.7 mpaka 1.8 mwa odzipereka athanzi, komanso odwala hypercholesterolemia - kuchokera ku 2 , 6 mpaka 3.4. Kupatula kusintha kwakukulu mu chizindikirochi, odwala omwe amalandila coumarin anticoagulants, nthawi ya prothrombin iyenera kutsimikizika musanayambe kugwiritsa ntchito Zokor komanso nthawi yayitali panthawi yopereka chithandizo. Chizindikiro cha INR chitakhazikika, kutsimikiza kwake kumayenera kuchitika pakanthawi kotsimikizika koyang'anira odwala omwe akuchitidwa ndi anticoagulant mankhwala.

Madzi a mphesa amakhala ndi gawo limodzi lomwe limaletsa CYP3A4 ndipo limatha kukulitsa kuchuluka kwa mankhwala omwe amapangidwa ndi enzyme iyi. Kugwiritsa ntchito chikho 1 cha madzi (250 ml) patsiku kulibe phindu. Komabe, mukamadya madzi ambiri (kuposa 1 lita imodzi patsiku) munthawi yamankhwala othandizira ndi simvastatin, kuchuluka kwa ntchito ya HMG-CoA reductase inhibitors kumachulukirachulukira. Pazifukwa izi, madzi ambiri a mphesa sayenera kumwa nthawi ya mankhwalawa.

Analogs of Zokor ndi: Simvastatin, Simvastatin Zentiva, Avestatin, Simvakard, Simlo, Aterostat, Levomir, Vabadin, Simgal, Zovatin, Simvor.

Pa mimba ndi mkaka wa m`mawere

Kugwiritsa ntchito mankhwalawa kumapangidwa pakanthawi mimba ndi kudyetsa mwana mkaka wa m'mawere. Mukamamwa simvastatin pa nthawi yomwe muli ndi pakati, zovuta zomwe zimachitika mu nthawi ya fetal zimatha kudziwika.

Pa mkaka wa mkaka, ngati kuli kotheka, ntchito Zokor, muyenera kusiya kudyetsa.

Ndemanga za Zokora

Ndemanga zambiri zimadziwika za Zokora, kutsimikizira momwe mankhwalawa amathandizira. Zake zogwira pophika zimathandiziradi kuchepetsa cholesterol. Komabe, kuti mupeze zotsatira zomwe zikuyembekezeredwa, ndikofunikira kuti mugwiritse ntchito mankhwalawa kwa nthawi yomwe madokotala amapita. Odwala amafotokoza zabwino akamagwiritsa ntchito simvastatin ngati njira yodzitetezera.

Kuphatikizika, mawonekedwe omasulidwa

Zokor imamasulidwa mumtundu wa mapiritsi okhala ndi ntchito. Amakhala ndi chowonda, pichesi (10 mg) kapena tan (20 mg) mu utoto.

Piritsi limodzi la Zocor lili ndi 10 kapena 20 mg ya simvastatin. Ntchito yothandizira imachitidwa ndi: ascorbic acid, citric acid, butylhydroxyanisole E320, cellulose, starch, magnesium stearate, shuga mkaka. Chipolopolo cha piritsi chimakhala ndi cellulose yosinthidwa, hypromellose, titanium dioxide (E 171), talc, chikasu, red iron oxide (E172, E171).

Zokor: Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizowo, Zokor amawonetsedwa kwa odwala omwe ali ndi cholowa kapena mtundu wa hypercholesterolemia monga kuwonjezera pa zakudya, pomwe izo zokha sizokwanira:

• kuchepa kwa ndende ya OH, X-LDL, TG, apolipoprotein B,
• kuchuluka kwa HDL-C odwala omwe ali ndi mtundu wa IIa / IIb hyperlipidemia,
• kuchepetsa kuchuluka kwa X-LDL / X-HDL, OH / X-HDL,
• m'munsi triglycerides.

Mapiritsi a Zokor amasonyezedwanso kwa anthu omwe ali pachiwopsezo chachikulu chotenga matenda a mtima: ndi matenda a shuga, stroke kapena matenda ena aliwonse amitsempha. Mapangidwe a metabolism a cholesterol, komanso mafuta ena metabolites, amathandizira kupewa kukula kwa zovuta.

Njira ya ntchito, Mlingo

Mankhwala a Zokor amatchulidwa pokhapokha njira yochizira zakudya zomwe zimayambitsa matenda a cholesterol. Kugwiritsa ntchito bwino kwa mapiritsi kumatengera kulanga kwa wodwala. Ngati satsatira chakudyacho, amachepetsa mpaka zero.

Mlingo wa tsiku ndi tsiku wa Zokor ndi 5-80 mg. Mapiritsi amatengedwa kamodzi / tsiku, madzulo, ndimadzi ambiri. Chakudya sichimakhudza mayamwidwe. Chifukwa chake, palibe chifukwa chogwirizanitsa kutenga Zokor ndi chakudya.

Kukhazikitsidwa kwa mankhwalawa kumayamba ndi mlingo wochepa, womwe ungabwezeredwe pambuyo masiku 28.

Odwala omwe ali ndi ischemic matenda a mtima / chiopsezo cha chitukuko, mankhwalawa ndi mankhwala 40 mg / tsiku. Kwa odwala ena omwe ali ndi hypercholesterolemia, mlingo woyambira nthawi zambiri amakhala 20 mg / tsiku.

Ndi chibadwa cha cholesterol kagayidwe kachakudya, Zokor zotchulidwa pa 40 mg / tsiku (kamodzi) kapena 80 mg / tsiku (katatu: 20 mg m'mawa, masana, 30 madzulo).

Kuthekera kwa kupereka mankhwala kwa ana a zaka 10 mpaka 17 ndi hyperlipidemia ndikokayikitsa. Phunziroli, gulu limodzi la ana linatenga Zokor kwa milungu 48, ndi placebo yachiwiri. Panalibe kusiyana kulikonse pakulolera. Koma pazamankhwala osatsutsika, ndikofunikira kuchita mayeso a nthawi yayitali ndikuwunika momwe mankhwalawa amakhudzira chitukuko cha malingaliro ndi kugonana.

1. Malangizo ogwiritsira ntchito

Kutenga Zokor kuyenera kutsagana ndi zakudya zomwe zimapangitsa kuti muchepetse mafuta m'thupi. Odwala amapatsidwa mankhwala kuchokera ku 5 mpaka 80 mg ya mankhwalawa kuti azigwiritsidwa ntchito tsiku lililonse asanagone. Ndikosatheka kupitilira muyeso wokwanira. Mlingo woyenera kwambiri amasankhidwa payekhapayekha, kusintha kulikonse mwa kuchuluka kwa Zocor sikuchitika mopitilira kamodzi pamwezi.

Mankhwalawa akuyenera kukhala a nthawi yayitali, pomwe mankhwalawo achotsedwa, wodwalayo amabwereranso komwe anali.

Mlingo wa mankhwala a matenda osiyanasiyana nthawi zambiri umakhala motere:

• Matenda a mtima a Ischemic, matenda a shuga, stroke - 40 mg tsiku lililonse, nthawi yomweyo, muyenera kutsatira kadyedwe ndikuchita maphunziro a Cardio
• Hypercholesterolemia - yokhala ndi nthenda yofatsa, 10-20 mg imayikidwa madzulo aliwonse ngati kuli kofunikira kutsitsa LDL ndiopitilira 45% -40 mg,
• Hypercholesterolemia ya banja - tikulimbikitsidwa kuti ayambe kulandira mankhwala a 40 mg madzulo kapena 80 mg katatu patsiku (20 + 20 + 40 nthawi imodzi).

Ngati Zokor adayikidwa limodzi ndi Danazol, Cyclosporin, Gemfibrozil ndi ma fiber ena kapena Niacin, mlingo waukulu wa tsiku lililonse sayenera kupitilira 10 mg.

Pamodzi ndi Verapamil kapena Amiodarone, mtengo wake ndi 20 mg. Odwala omwe ali ndi vuto lalikulu laimpso amalimbikitsidwa kuti achepetse kuchuluka kwake kwa tsiku mpaka 10 mg.

3. Zothandiza katundu

Zokor imalembedwa kwa odwala omwe ali ndi ischemic matenda a mtima kapena tsogolo la matendawa, hypercholesterolemia m'njira zosiyanasiyana, komanso matenda a shuga.

Mankhwala ali ndi izi:

• kulimbana ndi zizindikiro za matenda a mtima a ischemic,
• amachepetsa chiopsezo cha kufa chifukwa cha matenda amtima,
• imalepheretsa kukula kwamavuto akulu a mtima (mitsempha, mtima, ndi zina).
• Imachepetsa kufunika kogwirira ntchito kowongolera kwa magazi ndi mitundu ina ya magazi,
• Imafooketsa ziwopsezo za angina,
• otsika okwana cholesterol, LDL ndi B-lipoprotein,
• kumawonjezera HDL (cholesterol yopindulitsa),
• imayang'anira milingo ya triglyceride.

Mu matenda a shuga, Zokor imalepheretsa kuwoneka ngati kuvulala m'matumbo apamadzi, ndipo ngati matenda amitsempha ya m'magazi ndi hypercholesterolemia palimodzi imachedwetsa kukula kwa coronary atherosulinosis ndi zovuta zina.