Lozap 100 kuphatikiza

Lozap imapezeka mu mawonekedwe a mapiritsi okhala ndi mbali zonse pazovala zoyera za filimu. Chochita chake chimapangidwira pakamwa. Atadzaza matuza a mapiritsi 10 ndipo ananyamula m'matumba a 30, 60, 90 zidutswa. Piritsi lililonse limaphatikizapo:

• potaziyamu wolartan (wogwira ntchito),
• cellcrystalline mapadi,
• povidone
• magnesium wakuba,
• sodium croscarmellose,
• hypopellose,
• macrogol
• mannitol
• dimethicone
• talcum ufa
• utoto wachikasu.

Msika wamakono wamankhwala umapereka mitundu iwiri ya mankhwalawa: Lozap ndi Lozap kuphatikiza. Njira yoyamba ili ndi chinthu chokhacho chokhacho - losartan. Ndi angiotensin kutembenuza enzyme (ACE) inhibitor. Gawo lachiwiri lowonjezera lomwe limathandizira zotsatira za losartan potaziyamu ndi hydrochlorothiazide. Amachotsa madzimadzi owonjezera, omwe amathandizanso kuchepetsa kupanikizika. Pochiza matenda oopsa, makamaka mitundu yoopsa, ndikofunikira kugwiritsa ntchito mankhwala ophatikizidwa, popeza ali ndi mphamvu kwambiri.

Mu mankhwalawa mutha kugula mapiritsi a kukakamiza Lozap mu mitundu yosiyanasiyana: 12,5 mg, 50 ndi 100. Lozap kuphatikiza imodzi yokha - 50 mg ya potaziyamu losartan ndi 12,5 mg wa hydrochlorothiazide.

Zotsatira za pharmacological

Lozap bwino amachepetsa kuthamanga kwa magazi, amachepetsa katundu pa minofu ya mtima. Katunduyu wa mankhwalawa amaperekedwa ndi kuthekera kwake kupondeleza ntchito za ACE, zomwe zimathandiza kusintha angiotensin-I kukhala angiotensin-II.

Zotsatira zake, chinthu chomwe chimakhudza machitidwe a vasoconstriction, ndipo chifukwa chake, kuchuluka kwa magazi, angiotensin-II, kumayima kwathunthu kupanga thupi. Pokhapokha kupanga kwa horoni iyi kutsekeka komwe kungakhale kuchepa kwakukulu kwa kuthamanga kwa magazi ndipo kukhala kwawoko kungatheke.

Kuchita kwa mankhwalawa kumayamba mkati mwa ola limodzi kuchokera piritsi loyambirira ndikupanga mpaka tsiku. Kuchuluka kwake kumachitika motsutsana ndi maziko azoyendetsa pafupipafupi mankhwala. Pafupifupi njira zamankhwala zimakhala masabata 4-5. Ndizotheka kugwiritsa ntchito Lozap mwa anthu okalamba komanso achinyamata, makamaka popanga matenda oopsa oopsa.

Chifukwa cha kuchuluka kwa mitsempha yamagazi, zimakhala zosavuta kuti minofu ya mtima ikankhe magazi kudzera mwa iwo. Zotsatira zake, kukana kwa thupi pamavuto akuthupi ndi m'maganizo kumakulitsidwa kwambiri, zomwe zimathandizira mkhalidwe wa odwala omwe akudwala matenda a mtima. Kuphatikiza apo, mankhwalawa opanikizika Lozap amalimbitsa magazi kupita kumtima, amasintha magazi mu impso, kotero angagwiritsidwe ntchito nephropathy ya etiology ya etiology komanso mtima.

Lozap imaphatikizidwa bwino ndi mankhwala ena kuti achepetse kupsinjika. Chifukwa chokhala ndi diuretic mphamvu, zimathandiza kuchotsa madzi owonjezera mthupi. Mapiritsi a Lozap kuphatikizanso amakhala ndi mphamvu zambiri, popeza hydrochlorothiazide yomwe ilipo pakupanga imathandizira hypotensive zotsatira za losartan.

Katundu wowonjezera komanso wofunikira kwambiri wa mankhwalawa ndi kuthekera kwake kuchotsa uric acid mthupi ndi kuchepetsa kuchuluka kwake m'magazi. Pamapeto pa phwando, matenda a "kusiya" satenga.

Pharmacodynamics ndi pharmacokinetics

Losartan ndi wolimbana ndi angiotensin II receptor antagonist. Amachepetsa kukana kwathunthu m'matumbo, amathandizira kuchepetsa aldosterone ndi adrenaline m'magazi. Pali mawonekedwe a kukakamiza mu kufalikira kwa mapapo, komanso zizindikiro zamagazi. Kugwiritsa ntchito pafupipafupi, Lozap imalepheretsa kukhuthala kwa myocardium, kumawonjezera kukana kwa mtima kuzichita zolimbitsa thupi.

Kamodzi kamodzi ntchito, mphamvu ya mankhwalawo imafika pachimake patatha maola 6, kenako imachepera pang'onopang'ono ndikuyima pambuyo maola 24. Kwambiri hypotensive zotsatira zimachitika pafupifupi 3-5 milungu maphunziro.

Losartan imalowa mwachangu m'matumbo a m'mimba. Ku bioavailability wake kuli pafupifupi 33%; kumalumikizana ndi mapuloteni amwazi ndi 99%. Kuchuluka kwake mu seramu yamagazi kumatheka pambuyo pa maola 3-4. Kuchuluka kwa mankhwalawa sikusintha musanadye kapena mutatha kudya.

Mukamatenga potaziyamu wa losartan, pafupifupi 5% imachotsedwanso ndi impso mu mawonekedwe osasinthika ndipo mopitilira 5% mu mawonekedwe a metabolite yogwira. Woopsa milandu cirrhosis woledzera, ndende ya yogwira pophika ndi 5 peresenti kuposa anthu athanzi, ndipo metabolite yogwira ndi ka 17.

Zisonyezero zosankhidwa

Mankhwalawa amagwiritsidwa ntchito ngati mankhwala odziimira pawokha, komanso ngati gawo la zovuta mankhwala. Amawerengetsera zochizira zotsatirazi matenda ndi matenda:

• matenda oopsa
• kulephera kwa mtima (monga chida chowonjezera),
• matenda ashuga nephropathy odwala matenda a shuga,
• Kuchepetsa chiopsezo cha matenda amtima.

Contraindication

Kugwiritsa ntchito Lozap kumapangidwa chifukwa cha hyperkalemia, kutenga pakati, ndi mkaka wa m`mawere. Mankhwalawa sanalembedwe kwa ana osakwana zaka 18, popeza chitetezo chake ndi kugwira ntchito kwake sizinakhazikitsidwe. Contraindication imakhalanso hypersensitivity pazigawo za mankhwala kapena kusalolera kwawo. Lozap imagwiritsidwa ntchito mosamala pakuwonongeka kwa impso kapena chiwindi, ochepa hypotension, kapena kufooka thupi.

Malangizo ogwiritsira ntchito

Chimodzi mwazinthu zabwino za Lozap ndikugwiritsa ntchito pafupipafupi - 1 nthawi patsiku. Amayikidwira mosasamala chakudya. Muyezo tsiku lililonse la matenda oopsa ndi 50 mg. Ngati ndi kotheka, ikhoza kuwonjezeka mpaka 100 mg mu umodzi kapena iwiri. Ngati mankhwalawa mankhwala kwa odwala amene kumwa kwambiri Mlingo okodzetsa, ndiye kuti koyamba mlingo wa Lozap sayenera kupitirira 25 mg patsiku.

Malangizo ogwiritsira ntchito Lozap akuwonetsa kuti ndi vuto la mtima, mankhwalawa amatengedwa kuchokera ku 12,5 mg, ndiye kuti muyezowo umakulitsidwa pang'onopang'ono (kuonetsetsa kupezeka pakati pa sabata) kuti mupeze pafupifupi 50 mg. Odwala omwe ali ndi vuto la chiwindi, impso kapena dialysis, mankhwalawo amayeneranso kuchepetsedwa.

ZOFUNIKA KUDZIWA! Palibenso kupuma pang'ono, kupweteka mutu, kupsinjika ndi zizindikilo zina za HYPERTENSION! Dziwani njira zomwe owerenga athu amagwiritsa ntchito pothana ndi zovuta. Phunzirani njirayo.

Bwanji mukulembera mapiritsi a Lozap? Ndiwothandiza ngati kuli kofunika kuchepetsa mwayi wokhala ndi matenda amtima komanso kufa kwa odwala oopsa. Kuti muthane ndi zoterezi, mumamwa 50 mg tsiku lililonse tsiku lililonse. Ngati kuchuluka kwa kuthamanga kwa magazi sikukwaniritsidwa, ndiye kuti kusintha kwa mlingo ndi kuwonjezera kwa hydrochlorothiazide chithandizo kumafunika.

Dotolo ayenera kusankha mtundu wa mankhwalawa, popeza ndi yekhayo amene amadziwa kupsinjika ndi kuchuluka kwa lozap yomwe ili yothandiza kwambiri. Kusintha kwayekha kwa Mlingo kumatha kubweretsa zotsatirapo zoyipa.

Zotsatira zoyipa

Mwambiri, losartan potaziyamu amalekeredwa bwino. Zotsatira zoyipa sizimachitika, zimadutsa msanga, sizikufuna kuti mankhwalawa athe. Zochitika zoyipa zomwe zimapezeka mu milandu yochepera 1% sizikugwirizana ndi kutenga Lozap.

Kuchokera kumbali ya dongosolo lamkati lamanjenje, kukulira chizungulire, zikhalidwe za asthenic, kutopa kwambiri, chidwi, komanso kusokonezeka kwa kugona ndizotheka. Nthawi zina pamakhala parasthesia, kugwedeza, tinnitus, matenda okhumudwitsa. Nthawi zina, kuwonongeka kwa mawonekedwe, conjunctivitis, mutu wa mutu wa migraine adadziwika.

The kupuma dongosolo atha kuyankha kwa mankhwala kuchokera kumachitika kutsekeka kwa mphuno, chifuwa chowuma, kukula kwa rhinitis, kupuma kwa kufupika kwa mpweya.

Kuchokera m'mimba dongosolo: nseru, kusanza, kutsegula m'mimba, bloating, flatulence, kuchuluka acidity ya chapamimba madzi, kudzimbidwa. Komanso, mukamamwa mankhwalawa, kuoneka ngati kuphwanya kwamtima dongosolo: tachycardia, arrhythmia, bradycardia, angina pectoris.

Zotsatira zoyipa zomwe zimachitika pakhungu, genitourinary system ndi musculoskeletal system zimachitika osakwana 1% ya milandu.

Bongo

Pogwiritsa ntchito kwambiri mankhwala a Lozap, kuchepa kwambiri kwa magazi, kukula kwa tachycardia ndikotheka. Ngati mwangozi makonzedwe a mlingo waukulu wa mankhwalawa, mankhwala othandizira amachitika. Onetsetsani kuti mumalimbikitsa kusanza, kupukusa kwam'mimba, kukakamiza diresis.

Chofunikira: Hemodialysis siyitha kuchotsa potaziyamu losartan ndi metabolite yogwira thupi.

Kuchita ndi mankhwala ena

Mwina kugwiritsa ntchito Lozap kuphatikiza mankhwala ena a antihypertensive. Nthawi yomweyo, zochita zawo zimakulirakulira. Kugwirizana kwakukulu kwa losartan ndi digoxidine, phenobarbital, anticoagulants, cimetidine ndi hydrochlorothiazide sikuwunikidwa. Flucanazole ndi rifampicin amatha kuchepetsa kuchuluka kwa yogwira metabolite, komabe, kusintha kwachipatala chifukwa cha kuyanjana uku sikunaphunzire.

Ndi kukhazikitsidwa kwa Lozap kuphatikiza potaziyamu-yosasamala okodzetsa, kukhazikitsa hyperkalemia ndikotheka. Mphamvu yowonjezera ya losartan, monga mankhwala ena a antihypertensive, imatha kuchepetsedwa ndi indomethacin.

Gwiritsani ntchito muubwana ndi ukalamba

Lozap sagwiritsidwa ntchito mwa ana ochepera zaka 18, popeza sanayesedwe chifukwa chakuchita bwino komanso chitetezo. Mlingo woyambirira wa odwala okalamba sayenera kupitirira 50 mg. Pankhaniyi, chithandizo chikuyenera kuchitika moyang'aniridwa ndi dokotala komanso kuyesedwa pafupipafupi. Ngati mankhwalawa sakugwira ntchito, kusintha kwa mankhwalawa kapena kusintha kwake ndikofunikira.

Lozap ndi pakati

Kugwiritsa ntchito mankhwalawa osavomerezeka mu trimester yoyamba ya kutenga pakati, ndikutsutsana pambuyo pake. Zomwe zimapezeka pofufuza za zotsatira za ACE zoletsa mwana wosabadwayo m'miyezi itatu yoyambirira za kukula kwake sizikutsimikiza, koma chiwopsezo sichili kunja kwathunthu.

Ndizodziwika kuti kugwiritsa ntchito mankhwala osokoneza bongo mu lachiwiri, kotenga kachitatu kokhala ndi vuto kumakhala ndi vuto pa mwana wosabadwayo. Pali kuchepa kwa ntchito ya impso, kutsika pang'ono pakupanga mafupa a chigaza. Chifukwa chake, pakutsimikizira kuti ali ndi pakati, kudya kwa losartan potaziyamu kumayimitsidwa mwachangu, ndipo wodwalayo amamulembanso njira ina, yodekha yothandizira.

Palibe chidziwitso pakugawidwa kwa Lozap mu mkaka wa m'mawere. Chifukwa chake, akazi oyamwitsa amayeneranso kupewa kumwa mankhwalawa. Ngati pakufunika kugwiritsa ntchito mankhwalawa pakubala, kuyamwitsa kuyenera kutha.

Malangizo apadera

Kuphatikiza pakuphatikiza Lozap ndi mankhwala ena a antihypertensive, kuyendetsa kwake kungaphatikizidwe ndi insulin ndi mankhwala a hypoglycemic (Gliclazide, Metformin ndi ena). Ngati wodwalayo ali ndi mbiri ya edema ya Quincke, kuyang'aniridwa kosamalira kuchipatala ndikofunikira panthawi yamakonzedwe a losartan. Izi ndizofunikira kuti tipewe chiopsezo choti chibwererenso.

Ngati thupi lili ndi madzi ocheperako, omwe amayamba chifukwa cha zakudya zopanda mchere, kutsekula m'mimba, kusanza kosaloledwa, kapena kumwa mankhwala osokoneza bongo, ndiye kuti kumwa mankhwalawo kumatha kupangitsa kuti magazi achepetse kwambiri. Musanagwiritse ntchito Lozap, tikulimbikitsidwa kuti mubwezeretse mulingo wamagetsi am'mthupi kapena kugwiritsa ntchito mankhwalawa muyezo wochepa.

Popereka mankhwala kwa odwala omwe ali ndi vuto la impso, vuto la mtima kapena matenda a shuga, ndikofunikira kuyang'anira kuchuluka kwa creatinine ndi potaziyamu nthawi yonse ya chithandizo, chifukwa chiopsezo cha matenda oopsa kwambiri. Popeza matenda a impso kapena stenosis a mitsempha ya impso angayambenso kukulitsa kulephera kwa impso, losartan iyenera kugwiritsidwa ntchito mosamala kwambiri.

Osatengera Lozap ndi zoletsa zina za ACE, mwachitsanzo, Enalopril ndi Captopril. Poyerekeza ndi kugwiritsa ntchito mankhwala opaleshoni wamba, chitukuko cha hypotension ndichotheka.

Zotsatira pa kuthekera koyendetsa magalimoto

Popeza kudya kwa losartan potaziyamu kumatha kuyambitsa chizungulire komanso kukomoka, motero ndikulimbikitsidwa kusiya ntchito zilizonse zomwe zimafuna kuyang'ana kumbuyo kwa kumwa mankhwalawa. Kuphatikiza pa kuyendetsa.

Makampani amakono azamankhwala amapereka mitundu yambiri ya Lozap kuchokera kwa opanga osiyanasiyana. Pakati pawo, mutha kupeza mankhwala okwera mtengo kapena otsika mtengo. Mankhwala omwe amafunsidwa ndi mawonekedwe ake amatha kukhala ndi zotsatira zosiyana, chifukwa chake, mukasankha, muyenera kufunsa dokotala.

Mwa zolembera zamakono za Lozap, zomwe ndizodziwika bwino ndi izi:

Mankhwalawa onse ali ndi zisonyezo zofananira ndi contraindication kuti agwiritse ntchito, amasiyana mu mlingo, mtengo ndi wopanga.

Chofunika: Mankhwalawa sanapangidwire milandu yayikulu ya matenda oopsa. Zikatero, kuikidwa kwa mankhwala ovuta kumafunika.

Lorista ndi Lozap - zomwe zili bwino

Chithandizo chophatikizika mu mankhwala onsewa ndi chimodzimodzi. Amalandira kwa odwala omwe ali ndi matenda oopsa komanso kulephera kwa mtima. Komabe, mtengo wa Lorista ndiwotsika kwambiri kuposa Lzap. Yoyamba ikhoza kugulidwa mkati mwa ma ruble a 130 a mapiritsi 30, ndipo yachiwiri ndi ma ruble 280.

Mankhwala aliwonse amakhala ndi zabwino zake. Ndemanga za mankhwala a Lozap sikuti zimangosintha kwenikweni. Odwala ambiri amalankhula za momwe mankhwalawo amathandizira. Imasinthasintha msanga kupanikizika, ndikupanga bwino kwambiri odwala. Komabe, mankhwalawa sathandiza aliyense. Zotsatira zotsatirazi za Lozap zidadziwika:

• mutamwa mankhwala okhala ndi potaziyamu wolephera, odwala amayamba kutsokomola.
• kupezeka kwa tachycardia kunalembedwa,
• tinnitus
• mitundu ina ya matenda oopsa amafuna kuchuluka kopitilira muyeso umodzi,
• panali milandu ya kusowa koyenera, komwe kunafunikira kusintha kwa mlingo kapena kubwezeretsa mankhwala,
• Kukula mtima kwa kusuta kumatha.

Pojambula mfundo yokhudza momwe mankhwalawo amathandizira, titha kuzindikira kuti sioyenera aliyense. Ichi ndichifukwa chake kusankha kwa antihypertensive mankhwala kuyenera kuchitika pamodzi ndi adokotala. Simuyenera kusankha nokha mankhwalawa, chifukwa m'malo mopindulitsa, mutha kuvulaza thupi lanu.

Mtengo woyandikira ku Russia

Kutengera ndi kukula kwa phukusi la Lozap, mlingo wake, komanso wopanga, mtengo wake umatha kukhala pakati pa ma ruble 230-300 pa paketi iliyonse. Ma analogues amodzi ayenera kusankhidwa ndi adokotala okha.

Kodi mumakonda nkhaniyo?
Mpulumutseni!

Mudakali ndi mafunso? Afunseni mu ndemanga!

Mlingo.

Mapiritsi okhala ndi mafilimu.

Zofunikira mwakuthupi ndi zamankhwala: mapiritsi okhala ndi mawonekedwe achikasu, ovala utoto, wokhala ndi mphako mbali zonse ziwiri.

Gulu la mankhwala. Kuphatikizika kwa angiotensin II zoletsa. Angiotensin II okonda ndi okodzetsa. Nambala ya ATX C09D A01.

Mankhwala

Lozap® 100 Plus ndi kuphatikiza kwa losartan ndi hydrochlorothiazide.Zomwe zimagwiritsa ntchito mankhwalawa zimawonetsa antihypertensive zotsatira, zomwe zimachepetsa kuthamanga kwa magazi kwakukulu kwambiri kuposa gawo lililonse palokha. Chifukwa cha diuretic zotsatira, hydrochlorothiazide imawonjezera ntchito ya plasma renin (ARP), imathandizira kubisalira kwa aldosterone, imawonjezera kuchuluka kwa angiotensin II ndikuchepetsa mulingo wa potaziyamu mu seramu yamagazi. Kulandila kwa losartan kumatseketsa zovuta zonse za thupi za angiotensin II ndipo, chifukwa cha kuletsa kwa zotsatira za aldosterone, kumathandizira kuchepetsa kutaya kwa potaziyamu komwe kumakhudzana ndi kugwiritsa ntchito okodzetsa.

Losartan amakhala ndi mphamvu yochita uricosuric, amadutsa ngati mankhwalawo adatha.

Hydrochlorothiazide pang'ono amawonjezera kuchuluka kwa uric acid m'magazi; kuphatikiza kwa losartan ndi hydrochlorothiazide kumafooketsa hyperuricemia chifukwa cha okodzetsa.

Losartan ndi mankhwala opangira angiotensin II receptor antagonist (mtundu wa AT 1 receptors) wogwiritsa ntchito pakamwa.

Mukamagwiritsa ntchito losartan, kuponderezedwa kwa zotsatira zoyipa za angiotensin II pa renin secretion kumabweretsa kuwonjezeka kwa ntchito ya plasma renin (ARP). Kuwonjezeka kwa ARP kumayambitsa kuwonjezeka kwa kuchuluka kwa angiotensin II m'madzi am'magazi. Ngakhale kuwonjezeka kwa kuchuluka kwa zinthu izi, ntchito ya antihypertensive ndi kuchepa kwa kuchuluka kwa aldosterone m'magazi a plasma kumalimbikira, zomwe zikuwonetsa kutsekereza kwa angiotensin II receptors. Pambuyo pakutha kwa losartan, mtengo wa ARP ndi angiotensin II umatsika mpaka pamlingo woyamba m'masiku atatu.

Onse osokera ndi metabolite yake yogwira amakhala ndi mgwirizano waukulu wa AO 1 receptors kuposa AO 2 receptors. Metabolite yogwira imakhala yogwira kwambiri nthawi 10-5 kuposa losartan, yowerengedwa pa kulemera kwa thupi.

Malinga ndi kafukufuku yemwe adapangidwa kuti aunike kuchuluka kwa chifuwa cha odwala omwe amatenga losartan, poyerekeza ndi odwala omwe amalandila zoletsa za ACE, kuchuluka kwa chifuwa kwa odwala omwe amatenga losartan kapena hydrochlorothiazide anali pafupifupi ofanana ndipo nthawi yomweyo, otsika kwambiri kuposa Odwala kutenga ACE zoletsa.

Kugwiritsa ntchito potaziyamu wa losartan mwa odwala opanda matenda a shuga komanso kukhala ndi vuto losakanikirana ndi proteinuria kumachepetsa kuchuluka kwa proteinuria, komanso kuchulukitsidwa kwa extintion wa albumin ndi IgG immunoglobulin mwa kuchuluka kwakukulu.