Tricor 145 mg

Mapiritsi a 65 mg okhala ndi mafilimu

Piritsi limodzi lili

ntchito yogwira - fenofibrate wa micronized michere

zokopa: Hypromellose, sodium docusate, sucrose, sodium lauryl sulfate, lactose monohydrate, microcrystalline silonized cellulose, crospovidone, magnesium stearate.

kapangidwe ka chipolopolo: Opadry OY-B-28920 (mowa wamphamvu wa polyvinyl, titaniyamu wa oksijeni E171, talc, soya nyemba lecithin, xanthan chingamu).

Mapiritsi okhala ndi mawonekedwe osagwirizana ndi utoto wa filimu yoyera, wolemba "145" mbali imodzi ndi logo ya kampani mbali inayo.

Pharmacological zimatha mankhwala Tricor 145 mg

fenofibrate ndikutengera kwa fibroic acid. Mphamvu yake pa mbiri ya lipid, yomwe imawonedwa mwa anthu, imayanjanitsidwa ndi kuyambitsa kwa receptor yoyendetsedwa ndi proliferating factor alpha mtundu peroxisome (PPARA).
Kupanga kutsegula kwa PPARα, fenofibrate imakulitsa kukula kwa lipolysis komanso kuchotsedwa kwa TG yolemera tinthu tambiri kuchokera m'magazi a magazi mwa kuyambitsa lipoprotein lipase ndikuchepetsa mapangidwe a apoprotein CIII. Kutsegula kwa PPARcy kumapangitsanso kuwonjezeka kwa kapangidwe ka apoproteins AI ndi II.
Zotsatira zomwe zili pamwambapa za fenofibrate pa LP zimayambitsa kuchepa kwamagawo a VLDL ndi LDL, omwe ali ndi apoprotein B, komanso kuwonjezeka kwa gawo la HDL, lomwe lili ndi apoproteins AI ndi II.
Kuphatikiza apo, pakusintha kaphatikizidwe ndi katemera wa kachulukidwe ka VLDL, fenofibrate imakulitsa chiwonetsero cha LDL ndikuchepetsa kuchuluka kwa LDL, kuchuluka kwake komwe kumakulitsidwa ndi atherogenic lipoprotein phenotype, yomwe imawonedwa nthawi zambiri mwa odwala omwe ali pachiwopsezo cha matenda a coronary artery.
Munthawi ya mayeso a fenofibrate, kuchuluka kwa cholesterol kotsika ndi 20-25%, TG ndi 40-55%, ndipo mulingo wa cholesterol wa HDL unakwera ndi 10-30%. Odwala a hypercholesterolemia, momwe mulingo wa cholesterol wa LDL umachepetsedwa ndi 20- 35%, kuchuluka kwathunthu kogwirizana ndi cholesterol kumakhudzana ndi kuchepa kwa kuchuluka kwa cholesterol ya HDL cholesterol, LDL cholesterol ku HDL cholesterol kapena apoprotein B kuti apoprotein AI, omwe ali poizoni.
Chifukwa cha momwe imakhudzira cholesterol ya LDL ndi triglycerides, chithandizo cha fenofibrate chimakhala ndi zotsatira zabwino kwa odwala omwe alibe komanso hypercholesterolemia osakanikirana ndi hypertriglyceridemia, kuphatikizapo yachiwiri hyperlipoproteinemia, chimodzimodzi monga omwe apezeka mu mtundu II matenda a shuga.
Mpaka pano, palibe zotsatira za maphunziro omwe amayendetsedwa kwa nthawi yayitali kuti awonetse mphamvu ya fenofibrate yokhudzana ndi kupewera koyambirira komanso kwachiwiri kwa mavuto a atherosulinosis.
Zowonjezera zowonjezera za cholesterol (xanthoma tendinosum et tuberosum) zimatha kuchepa kwambiri kapena kutha kwathunthu panthawi ya fenofibrate.
Odwala omwe ali ndi milingo yayikulu ya fibrinogen omwe amathandizidwa ndi fenofibrate, kuchepa kwakukulu kwa chizindikiro ichi kunadziwika. Zizindikiro zina zotupa, monga CRP, zimachepetsedwa ndi chithandizo cha fenofibrate.
Mphamvu ya uricosuric ya fenofibrate, yomwe imapangitsa kutsika kwa uric acid ndi 25%, imatha kuwonedwa kuti ndiwothandiza kwambiri kwa odwala omwe ali ndi dyslipidemia kuphatikiza ndi hyperuricemia.
Zinapezeka kuti fenofibrate imatha kuchepetsa kuphatikiza kwa platelet yotengedwa ndi adenosine diphosphate, arachidonic acid, ndi epinephrine.
Mapiritsi a 145 mg Tricor ali ndi fenofibrate mwanjira ya nanoparticles.
Zogulitsa
Kwambiri ndende ya madzi am`magazi zimatheka patatha maola 2-4 pambuyo m`kamwa. The ndende mu madzi am`magazi khola okhazikika mankhwala.
Mosiyana ndi kukonzekera kwina kwa fenofibrate, kuchuluka kwakukulu mu plasma ndi kuyamwa kwa mankhwala ambiri, omwe amakhala ndi fenofibrate nanoparticles, samakhudzidwa ndi kudya. Chifukwa chake, mapiritsi a Traicor 145 mg angagwiritsidwe ntchito mosasamala kanthu za chakudya.
Kafukufuku wokhudza kuperewera kwa mankhwalawa, omwe anaphatikiza kuyamwa kwa mapiritsi a 145 mg kwa abambo ndi amayi athanzi pamimba yopanda kanthu komanso panthawi yokhala ndi mafuta ambiri, adawonetsa kuti kudya zakudya sizinakhudze mayamwidwe (a AUC ndi kuchuluka kwa plasma ndende) ya fenofibric acid.
Kugawa
Fenofibric acid imakhala ndi milingo yayikulu kwambiri yomanga plasma albin (kuposa 99%).
Kutetemera ndi Kuwona
Pambuyo pakamwa, fenofibrate imatulutsidwa mofulumira ndi ma esterases ku metabolite yogwira ya fenofibric acid. Fenofibrate yosasinthika m'madzi a m'magazi samapezeka. Fenofibrate si gawo limodzi la CYP 3A4 ndipo satenga nawo mbali mu hepatic microsomal metabolism.
Fenofibrate imapukusidwa makamaka mkodzo. Imatsala pang'ono kuchotsedwa m'masiku 6. Imasungidwa makamaka mu fenofibric acid ndipo imalumikizana ndi glucuronide. Mwa odwala okalamba, chiwonetsero chonse cha plasma cha fenofibric acid sichimasintha.
Kinetic maphunziro atatha kumwa kamodzi komanso kumwa mankhwala kwa nthawi yayitali adawonetsa kuti fenofibrate siikuwumitsidwa ndi thupi.
Fenofibric acid samapukusidwa ndi hemodialysis.
Hafu ya moyo wa fenofibric acid kuchokera ku madzi a m'magazi ndi maola 20.

Mankhwala

Pharmacokinetics

Mapiritsi a Tricor omwe amaphatikizidwa ndi 145 mg ali ndi 145 mg ya fenofibrate yowonetsedwa mwanjira ya nanoparticles.

Zogulitsa. Pambuyo pakukonzekera kwa pakamwa kwa Tricor, 145 mg ya Cmax (ndende yayikulu) ya fenofibroic acid imatheka pambuyo pa maola 2-4. Pogwiritsa ntchito nthawi yayitali, ndende ya fenofibroic acid mu plasma imakhalabe yokhazikika, mosasamala kanthu za mawonekedwe a wodwala. Mosiyana ndi kapangidwe kakale ka fenofibrate, Cmax mu plasma ndi kuchuluka kwathunthu kwa micenized fenofibrate mwanjira ya nanoparticles (Tricor 145 mg) sizimatengera pakudya panthawi yomweyo (chifukwa chake, mankhwalawa amatha kutengedwa nthawi iliyonse, mosasamala kanthu za kudya).

Fenofibroic acid ndi okhazikika komanso woposa 99% womangidwa ku plasma albin.

Kutetemera ndi chimbudzi

Pambuyo pakukonzekera pakamwa, fenofibrate imatulutsidwa mofulumira ndi esterases kuti fenofibroic acid, yomwe ndi metabolite yake yayikulu. Fenofibrate sapezeka mu plasma. Fenofibrate si gawo limodzi la CYP3A4, silimagwira microsomal metabolism mu chiwindi.

Fenofibrate imapukusidwa makamaka mkodzo mu mawonekedwe a fenofibroic acid ndi glucuronide conjugate. Pasanathe masiku 6. fenofibrate imachotsedweratu pafupifupi kwathunthu. Odwala okalamba, chiwonetsero chonse cha fenofibroic acid sichimasintha. Hafu ya moyo wa fenofibroic acid (T1 / 2) ndi pafupifupi maola 20. Pamene hemodialysis siziwonetsedwa. Kinetic Kafukufuku wasonyeza kuti fenofibrate siziunjikana pambuyo pa mlingo umodzi komanso kugwiritsa ntchito nthawi yayitali.

Mankhwala

Tricor ndi othandizira kutsika kwa lipid kuchokera pagulu la michere ya fibroic acid. Fenofibrate imatha kusintha zomwe zili mu lipid mthupi chifukwa chogwiritsa ntchito ma PPAR-α receptors (alpha receptors yolembedwa ndi peroxisome proliferator).

Fenofibrate imathandizira lipolysis ya plasma ndi kuchulukitsidwa kwa lipotrotein ya atherogenic yokhala ndi mawonekedwe apamwamba a triglycerides poyambitsa PPAR-α receptors, lipoprotein lipase ndikuchepetsa kapangidwe ka apoprotein C-III (apo C-III). Zotsatira zomwe zafotokozedwa pamwambapa zimayambitsa kuchepa kwa zomwe zidutswa za LDL ndi VLDL, zomwe zimaphatikizira apoprotein B (apo B), komanso kuwonjezeka kwa zomwe zili muzinthu za HDL, zomwe zimaphatikizapo apoprotein A-I (apo A-I) ndi apoprotein A-II (apo A-II). . Kuphatikiza apo, chifukwa cha kukonza kuphwanya kaphatikizidwe ndi katemera wa VLDL, fenofibrate imakulitsa kuwonekera kwa LDL ndikuchepetsa zomwe zimakhala ndi LDL yaying'ono (kuwonjezeka kwa LDL kumeneku kumawonedwa mwa odwala omwe ali ndi atherogenic lipid phenotype ndipo amagwirizana ndi chiwopsezo chachikulu cha CHD).

Pa maphunziro azachipatala, zidadziwika kuti kugwiritsa ntchito fenofibrate kumachepetsa cholesterol yonse ndi 20-25% ndi triglycerides ndi 40-55% ndi chiwonjezero cha HDL-C ndi 10-30%. Odwala omwe ali ndi hypercholesterolemia, momwe mulingo wa Chs-LDL amachepetsedwa ndi 20-35%, kugwiritsa ntchito fenofibrate kunapangitsa kutsika kwa ziwerengero: chonse Chs / Chs-HDL, Chs-LDL / Chs-HDL ndi pomwe B / apo A-I, omwe ali chizindikiro cha atherogenic chiopsezo.

Pali umboni kuti ma fibrate amatha kuchepetsa kuchuluka kwa zochitika zomwe zimakhudzana ndi matenda a mtima, koma palibe umboni wonena za kuchepa kwa kufedwa kwathunthu kapena kwachiwiri kupewa matenda amtima.

Mukamalandira mankhwala a fenofibrate, zowonjezera zowonjezera za XC (tendon ndi tuberous xanthomas) zimatha kuchepa kwambiri mwinanso kutha kwathunthu. Odwala omwe ali ndi milingo yayikulu kwambiri ya fibrinogen amathandizidwa ndi fenofibrate, kuchepa kwakukulu kwa chizindikirocho kunadziwika, komanso kwa odwala omwe ali ndi milingo yayitali ya lipoproteins. Mankhwalawa fenofibrate, kuchepa kwa kuchuluka kwa mapuloteni a C omwe amachititsa kuti magazi azisungunuka ndi zina.

Kwa odwala omwe ali ndi dyslipidemia ndi hyperuricemia, mwayi wowonjezera ndikuti fenofibrate imakhala ndi uricosuric, zomwe zimapangitsa kuchepa kwakukulu kwa uric acid ndi pafupifupi 25%.

Pakafukufuku wazachipatala, fenofibrate adawonetsedwa kuti achepetse kuphatikiza kwa platelet chifukwa cha adenosine diphosphate, arachidonic acid, ndi epinephrine.

Zizindikiro zogwiritsidwa ntchito

Kuphatikiza pa zakudya komanso njira zina zopanda mankhwala

(zolimbitsa thupi, kuchepa thupi) zotsatirazi:

kwambiri hypertriglyceridemia ndi kapena wopanda mafuta ochepa

- Hyperlipidemia wosakanizika pamaso pa contraindication kapena tsankho kwa ma statins

- osakanikirana Hyperlipidemia odwala omwe ali ndi chiopsezo cha mtima kuphatikiza ma statins osakwanira kukonza kukonzanso kwa triglycerides ndi cholesterol yayikulu

Mlingo ndi makonzedwe

Mankhwala Tricor 145 mg amatengedwa nthawi iliyonse masana, mosasamala kanthu za kudya, piritsi liyenera kumeza lonse, osafuna kutafuna, ndi kapu yamadzi.

Kuphatikiza ndi chakudya, Tricor 145 mg imayikidwa pamaphunziro atali, mphamvu yake yomwe amayenera kuyang'aniridwa nthawi ndi nthawi.

Kuchita bwino kwamankhwala kumayesedwa pogwiritsa ntchito mitundu ya lipid spectrum (cholesterol yathunthu, cholesterol yotsika, triglycerides).

Ngati pakadutsa miyezi itatu palibe kusintha pakumveka kwa lipid, kuganiziridwa kuyenera kuperekedwa poika chithandizo chowonjezera kapena chothandizira.

Akuluakulu amatchulidwa piritsi limodzi la Tricor 145 mg 1 nthawi patsiku. Odwala omwe amatenga kapisozi imodzi ya fenofibrate 200 mg amatha kusintha piritsi limodzi la Tricor 145 mg patsiku popanda kusintha kwa mlingo wina.

Odwala omwe amatenga piritsi limodzi la fenofibrate 160 mg patsiku, amatha kusintha kuti atenge piritsi limodzi la Tricor 145 mg popanda kusintha kwa mlingo wina.

Odwala okalamba popanda kulephera kwa aimpso, muyezo wachikulire wothandiza umavomerezeka.

Kugwiritsa ntchito mankhwalawa odwala matenda a chiwindi osati kuphunzira.

Zotsatira zoyipa

Zotsatira zotsatirazi zinaonedwa pamayeso azachipatala omwe amayendetsedwa ndi placebo (n = 2344):

- kupweteka kwam'mimba, kusanza, kusanza, kutsegula m'mimba, kutsekemera (kufatsa)

- okwera chiwindi transaminases

- mitsempha yakuya, pulmonary thromboembolism

- khungu hypersensitivity zimachitikira: zotupa, kuyabwa, urticaria

- myalgia, myositis, kukokana kwa minofu, kufooka kwa minofu

- kuchuluka kwa creatinine m'magazi

- kuchepa kwa hemoglobin, kuchepa kwa zomwe leukocytes

- alopecia, photosensitivity zimachitika

- kuchuluka kwa urea m'madzi a m'magazi

-kumva kutopa, chizungulire

Zotsatira zoyipa zomwe zimadziwika posachedwa pamsika (zomwe sizimadziwika):

- jaundice, cholelithiasis zovuta (mwachitsanzo cholecystitis, cholangitis, colic biliary)

kupweteka kwakhungu pakhungu (mwachitsanzo, erythema multiforme, Stevens-Johnson syndrome, poermal necrolysis yoopsa)

Kugwiritsa ntchito kwa mankhwala Tricor 145 mg

Kuphatikiza pa chithandizo cha zakudya, mankhwalawa amapangidwira chithandizo cha nthawi yayitali, mphamvu yake yomwe imayenera kuyang'aniridwa nthawi ndi nthawi podziwa kuchuluka kwa lipids mu seramu yamagazi (chonse cholesterol, LDL cholesterol, TG).
Ngati mutagwiritsa ntchito mankhwalawa kwa miyezi ingapo (mwachitsanzo, miyezi itatu), kuchuluka kwa lipids mu seramu yamagazi sikunatsike mokwanira, ndikofunikira kulingalira poika chithandizo chamankhwala kapena mitundu ina ya mankhwalawa.
Mlingo
Akuluakulu
Mlingo womwe umalimbikitsa ndi 145 mg (piritsi 1) kamodzi patsiku. Odwala omwe amatenga fenofibrate pa mlingo wa 200 mg akhoza kusinthidwa ndi piritsi 1 la Tricor 145 mg popanda kusankha kwina kwa mlingo.
Odwala okalamba
Kwa odwala okalamba, njira yabwino yokhazikika imalimbikitsidwa.
Odwala omwe ali ndi vuto la impso
Odwala omwe ali ndi vuto la aimpso ayenera kuchepetsa mlingo. Odwala oterewa amalangizidwa kuti amwe mankhwala omwe amakhala ndi mphamvu ya fenofibrate (100 mg kapena 67 mg).
Ana
Tricor 145 mg imapangidwa kuti athandize ana.
Matenda a chiwindi
Kugwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi matenda a chiwindi sikunaphunzire.
Njira yogwiritsira ntchito
Mapiritsi ayenera kumeza lonse ndi kapu yamadzi.
Mapiritsi a 145 mg Traicor amatha kumwa nthawi iliyonse masana, mosasamala zakudya.

Contraindication Tricor 145 mg

Hepatic insufficiency (kuphatikizapo biliary cirrhosis), kulephera kwa impso, ubwana, hypersensitivity kuti fenofibrate kapena magawo ena a mankhwala, photosensitivity kapena Phototoxic reaction pamankhwala othandizira ndi fibrate kapena ketoprofen m'mbuyomu, matenda a ndulu (gallstone).
Tricor 145 mg sayenera kutengedwa kwa odwala omwe ali ndi ziwengo kuti asankhe batala la soya kapena lecithin, kapena zogwirizana ndi zotheka (chiopsezo cha hypersensitivity reaction).

Zotsatira zoyipa za mankhwalawa Tricor 145 mg

Zotsatira zoyipa zimawonetsedwa ndi ma frequency mwanjira iyi: kawirikawiri (1/10), nthawi zambiri (1/100, ≤1 / 10), infrequently (1/1000, ≤1 / 100), kawirikawiri (1/10 000, ≤1 / 1000), kawirikawiri kwambiri (1/100 000, ≤1 / 10 000), kuphatikiza milandu yokhayokha.
Kuchokera m'mimba thirakiti
Nthawi zambiri: kupweteka kwam'mimba, mseru, kusanza, kutsegula m'mimba ndi kusweka, zolimbitsa kwambiri.
Nthawi zambiri: kapamba.
Pa mbali ya chiwindi ndi biliary thirakiti
Nthawi zambiri: kuwonjezeka kwapang'onopang'ono kwa ma seramu transaminases (onani MALANGIZO OTHANDIZA).
Nthawi zambiri: mapangidwe a miyala mu ndulu.
Osowa kwambiri: milandu ya chiwindi. Ngati zizindikiro (mwachitsanzo, jaundice, kuyabwa) zikuwonetsa kuchitika kwa chiwindi, mayeso a labotale ayenera kuchitidwa kuti atsimikizire kuti ali ndi vutoli ndipo ngati kuli koyenera, siyani mankhwalawo (onani MALANGIZO OTHANDIZA).
Pa khungu ndi subcutaneous minofu
Zosazolowereka: zotupa, kuyabwa, ming'oma, kapenanso kukhudzika kwa zithunzi.
Pafupipafupi: alopecia.
Osowa kwambiri: photosensitivity of khungu of erythema, mawonekedwe a veicles kapena mafinya m'magawo khungu lomwe limayatsidwa ndi kuwala kwa dzuwa kapena ma radiation oyipa a ultraviolet nthawi zina (ngakhale atagwiritsa ntchito miyezi yambiri osagwiritsa ntchito zovuta).
Kuchokera ku minculoskeletal system
Pafupipafupi: kusokoneza myalgia, myositis, minofu kukokana, ndi kufooka kwa minofu.
Osowa kwambiri: rhabdomyolysis.
Kuchokera pamtima
Nthawi zambiri: venous thromboembolism (pulmonary embolism, deep vein thrombosis).
Pa gawo la magazi ndi dongosolo la zamitsempha
Si kawirikawiri: kuchepa kwa hemoglobin ndi maselo oyera amwazi.
Kuchokera ku dongosolo lamanjenje
Si kawirikawiri: kufooka kwa kugonana, kupweteka mutu.
Pa mbali ya kupuma dongosolo, chifuwa ndi Mediastinum
Zosowa kwambiri: chibayo chamkati.
Zotsatira zakufufuza
Pafupipafupi: seramu creatinine ndi urea.

Malangizo apadera ogwiritsira ntchito mankhwalawa Tricor 145 mg

Kukhazikitsidwa kwa Tricor 145 mg kumasonyezedwa makamaka pakakhala zinthu zoopsa zodziwika monga matenda oopsa (matenda oopsa) ndi kusuta.
Pankhani ya sekondale hypercholesterolemia, musanayambe chithandizo ndi TRICOR 145 mg, ndikofunikira kuchitira bwino zomwe zimayambitsa kapena kuthetsa zifukwa zina zomwe zingayambike, monga mtundu wowonongeka wa matenda ashuga II, mellitus, hypothyroidism, nephrotic syndrome, dysproteinemia (mwachitsanzo, myeloma ), hyperbilirubinemia, pharmacotherapy (kuletsa kwamlomo, corticosteroids, antihypertensive mankhwala, proteinase inhibitors zochizira matenda a HIV), uchidakwa.
Zotsatira zamankhwala ziyenera kuyendetsedwa mwa kudziwa mulingo wa lipids mu seramu yamagazi (chonse cholesterol, LDL, TG). Ngati zotsatira zokwanira sizinachitike kwa miyezi ingapo (mwachitsanzo, miyezi itatu), ndikofunikira kuganizira zakusankhidwa kwa chithandizo chowonjezera kapena mitundu ina ya mankhwalawa.
Odwala omwe ali ndi hyperlipidemia omwe akutenga estrogen kapena njira zakulera zomwe zimakhala ndi estrogens, ndikofunikira kuyang'ana ngati hyperlipidemia ndiyoyambirira kapena yachiwiri, popeza kugwiritsidwa ntchito kwa mankhwala otulutsa pakamwa kumatha kukulitsa milingo ya lipid.
Ntchito ya chiwindi
Monga momwe amagwiritsidwira ntchito ndi mankhwala ena otsitsa a lipid, kuwonjezereka kwa ntchito ya transaminase kumadziwika mwa odwala ena. Nthawi zambiri, inali yochepa, yofatsa komanso yokhala yofanana. Ndikulimbikitsidwa kuyang'ana ntchito ya transaminases miyezi 3 iliyonse myezi 12 yoyambirira yamankhwala. Ayenera kuwunika momwe odwala omwe awonetsa kuwonjezeka kwa kuchuluka kwa ma transaminase. Ndi kuwonjezeka kwa mulingo wa AlAT ndi AsAT ochulukitsa katatu poyerekeza ndi malire apamwamba, mankhwalawo ayenera kusiyidwa.
Pancreatitis
Odwala omwe adatenga fenofibrate, milandu ya kapamba idadziwika. Kupezeka kwake kungakhale chifukwa cha kulephera kwa mankhwalawa odwala omwe ali ndi vuto lalikulu la hypertriglyceridemia, kuthamangitsidwa kwa mankhwalawa kapena chifukwa china, mwachitsanzo, mwala mu bile ducts kapena kutsekeka kwa duct wamba wa bile.
Minofu
Mankhwala oopsa a minofu, kuphatikizapo milandu yovuta kwambiri ya rhabdomyolysis, adadziwika ndi michere komanso mankhwala ena otsitsa a lipid. Pafupipafupi imachulukanso ndi hypoalbuminemia kapena kulephera kwaimpso. Kuopsa kwa minofu yomwe ingayambitse odwala omwe ali ndi vuto la myalgia, kukokana komanso kufooka kwa minofu, komanso kuwonjezereka kwa CPK (nthawi 5 poyerekeza ndi chizolowezi), kuyenera kukumbukiridwa. Muzochitika izi, chithandizo cha TRICOR 145 mg chiyenera kuyimitsidwa.
Ngati pali zina zomwe zimapangitsa chidwi cha myopathy ndi / kapena rhabdomyolysis, kuphatikiza zaka zopitilira 70, matenda amtundu wobadwa nawo wodwala kapena achibale, matenda a impso, hypothyroidism, kapena uchidakwa, odwala atha kukhala ndi chiopsezo chowonjezeka cha rhabdomyolysis. Mwa odwala oterowo, ndikofunikira kupenda mosamalitsa phindu ndi ngozi ya chithandizo ndi Triicor 145 mg.
Chiwopsezo cha zovuta zakupha minofu chikhoza kuchuluka ngati mankhwalawo amalembedwa nthawi yomweyo ngati fupa lina kapena HMG-CoA reductase inhibitor, makamaka pamaso pa matenda amisempha yofanana. Chifukwa chake, ndikofunikira kuperekera kuphatikizidwa kwa fenofibrate ndi statin kokha kwa odwala omwe ali ndi vuto lowopsa la dyslipidemia komanso chiopsezo cha matenda amtima osagwirizana ndi mbiri yamatenda a minofu ndikupanga chithandizo poyang'aniridwa mozama kuti athe kuyipa kwa minofu.
Impso
Kuchiza kuyenera kusiyidwa ngati gawo la creatinine likuwonjezeka ndi zoposa 50% poyerekeza ndi malire apamwamba. Ndikulimbikitsidwa kulingalira zakufunika kowunika milingo ya creatinine m'miyezi yoyambirira atangoyamba kumene chithandizo.
Tricor 145 mg ili ndi lactose, kotero odwala omwe ali ndi matenda obadwa nawo monga galactose tsankho, kuchepa kwa lappase kapena glucose-galactose malabsorption sayenera kumwa mankhwalawa.
Tricor 145 mg ili ndi sucrose, kotero, odwala omwe ali ndi matenda obadwa nawo monga fructose tsankho, shuga-galactose malabsorption kapena sucrose-isomaltase akusowa kumwa mankhwalawa.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Zambiri zokwanira zamagwiritsidwe ntchito ka fenofibrate panthawi yapakati sizipezeka. Kafukufuku wazinyama sanakhazikitse zotsatira za teratogenic. Mimbulu ya poizoni yadziwika ndi Mlingo wa poizoni kwa mayi. Chiwopsezo chomwe chingakhalepo kwa anthu sichikudziwika, chifukwa chake, Tricor 145 mg ingagwiritsidwe ntchito panthawi yapakati pokhapokha kuwunika mosamala phindu / chiopsezo.
Palibe deta pakumasulidwa kwa fenofibrate ndi / kapena ma metabolites ake mkaka wa m'mawere, chifukwa chake, Tricor 145 mg sayenera kutengedwa ndi amayi omwe akuyamwitsa.
Kutha kukopa momwe zinthu zikuyendera mukamayendetsa magalimoto kapena kugwira ntchito ndi zina. Palibe zotsatira zomwe zidadziwika.

Mapulogalamu Ochitira Mankhwala Tricor 145 mg

Ma anticoagulants amlomo
Fenofibrate imathandizira mphamvu ya anticoagulants pamlomo ndipo imatha kuwonjezera ngozi yotuluka magazi. Ndikulimbikitsidwa kuti muyezo wa anticoagulants mutha kuchepetsedwa ndi 1/3 koyambirira kwa mankhwalawa kenako kuwonjezeka kwapang'onopang'ono, ngati kuli kofunikira, motsogozedwa ndi INR (chiwembu cha mayiko wamba).
Cyclosporin
Milandu ingapo yayikulu ya mkhutu yaimpso inadziwika ndi kugwiritsa ntchito fenofibrate ndi cyclosporine, motero, mwa odwala, ntchito yaimpso iyenera kuyang'aniridwa mosamala. Kuchiza ndi TRICOR 145 mg kuyenera kusiyidwa pokhapokha patadutsa kwambiri magawo a labotale.
HMG-CoA reductase inhibitors ndi ma fiber ena
Chiwopsezo cha kuwonongeka kwakukuru kwa minofu imakulitsidwa pomwe chikugwiritsidwa ntchito ndi HMG-CoA reductase inhibitors kapena ma fiber ena. Kuphatikiza uku kuyenera kugwiritsidwa ntchito mosamala ndikuwunika mosamala mawonekedwe akuwoneka ngati owopsa m'mitsempha (onani MALANGIZO OTHANDIZA).
Cytochrome P450 Enzymes
Kafukufuku mu vitro kugwiritsa ntchito ma hepatic microsomes, fenofibrate ndi fenofibric acid sizoletsa cytochrome (CYP) P450 isoforms CYP 3A4, CYP 2D6, CYP 2E1 kapena CYP 1A2. Ndi ochepera zoletsa za CYP 2C19 ndi CYP 2A6 ndipo ali ndi mphamvu yofooka kapena yolimbitsa thupi ya CYP 2C9 pamankhwala othandizira, omwe amayenera kukumbukiridwa mukamaperekedwa ndi mankhwala omwe amaphatikizidwa ndi gawo la izi cytochrome P450 isoforms.