Meridia chilangizo chowongolera: mawonekedwe ndi malingaliro okhudzana ndi kugwiritsa ntchito mankhwalawa

Kuti achepetse thupi, atsikana ndi amayi ambiri omwe akufuna kuti akhale ochepa kwambiri, amwa mankhwala apadera. Zina mwazo zili ndi zinthu monga sibutramine. Kutengera izi, mankhwalawa Meridia wochepetsa thupi amapangidwa.

Musanachepetse thupi motere, muyenera kuphunzira mwatsatanetsatane malangizo ogwiritsa ntchito Meridia, omwe aperekedwa pansipa.

Meridia: kapangidwe ndi mfundo zoyenera kuchitapo

The yogwira pophika mankhwala Meridia ndi subatramine hydrochloride monohydrate. Monga ma adjuvants, mankhwalawa amakhala ndi zinthu monga silicon dioxide, titanium dioxide, gelatin, cellulose, sodium sulfate, utoto, etc. Makapiritsi nthawi zambiri amagwiritsidwa ntchito pochiza anthu onenepa.

Mankhwala Meridia akupezeka mu mawonekedwe a makapisozi osiyanasiyana Mlingo:

• Ma milligram 10 (chigobacho chimakhala ndi utoto wamtambo wamtambo, ufa woyera mkati),
• Ma milligram 15 (mlanduwo uli ndi mtundu wa buluu loyera, zomwe zili mkati mwake ndi ufa woyera).

Chochita chotsatsira cha Meridia chimakhala ndi mitundu yambiri yazithandizo ndipo chimakhala ndi zotsatirazi:

• amachulukitsa kuchuluka kwa serotonin ndi norepinephrine mu zolandilira zamanjenje,
• imachepetsa chilakolako
• kumapereka chodzaza,
• Matenda a hemoglobin komanso shuga
• kumawonjezera kutentha kwa thupi,
• lipid (mafuta) kagayidwe,
• kumapangitsa kusweka kwamafuta a bulauni.

Zigawo za mankhwalawa zimatengedwa mwachangu m'matumbo, zimagwidwa m'chiwindi ndikufikira pazokwanira maola atatu pambuyo pakulowetsa. Zinthu zofunikira zimachotsedwa m'thupi pakukonzekera komanso kuwonongeka.

Zizindikiro zogwiritsidwa ntchito

Kugwiritsa ntchito mankhwalawa Meridia akuwonetsedwa kwa anthu ngati chithandizo chokonzanso matenda monga:

• kunenepa kwambiri kwamankhwala am'mimba, komwe mndandanda wam'mimba umaposa kilogalamu 30 pachikuta chilichonse,
• Kunenepa kwambiri, komwe kumayendera limodzi ndi matenda a shuga kapena kufooka kwa maselo amafuta, pomwe mendulo ya thupi imaposa ma kilogalamu 27 pa mita imodzi.

Malangizo ogwiritsira ntchito

Tengani makapisozi a Meridia molingana ndi malangizo, omwe nthawi zonse amaphatikizidwa ndi mankhwalawa:

• kumwa makapisozi kamodzi patsiku (mankhwalawa samatetemera, koma kutsukidwa ndi kapu yamadzi oyera),
• ndibwino kugwiritsa ntchito mankhwala a anorexigenic m'mawa musanadye kapena chakudya,
• Mlingo woyamba wa Meridia uyenera kukhala mamiligalamu 10,
• Ngati mankhwalawa amalekerera bwino, koma osapereka zotsatira zake (m'mwezi womwe kulemera kwa wodwalayo kumatsika ndi zosakwana ma kilogalamu awiri), mulingo wa tsiku ndi tsiku utha kuwonjezeredwa mpaka ma milligram 15,
• ngati m'miyezi itatu yoyambirira ya kumwa mankhwalawo, kulemera kunachepa ndi 5% yokha (pomwe wodwalayo amatenga makapisozi mu gawo la ma milligram 15), kugwiritsa ntchito Meridia kuyimitsidwa,
• Kuchotsa makapisozi kumafunikanso ngati munthu atayamba kuchepa thupi pang'ono osayamba kuchoka, koma m'malo mwake, apezeke ma kilogalamu (kuchokera ma kilogalamu atatu ndi pamwambapa),
• kumwa mankhwala a Meridia sikungakhale kuposa miyezi 12 yotsatizana,
• mukumwa mankhwala a anorexigenic, wodwalayo ayenera kutsatira zakudya, kutsatira zakudya zomwe adotolo adachita ndikuchita masewera olimbitsa thupi, munthu ayenera kukhalabe ndi moyo womwewo atalandira chithandizo (apo ayi, zotsatira zake zimatha msanga),
• Atsikana ndi amayi omwe ali ndi zaka za kubala mwana ndikumwa mankhwala a Meridia, ayenera kutetezedwa ku mimba, pogwiritsa ntchito njira zodalirika zolerera.
• Mapiritsi a Meridia samalimbikitsidwa kuti aphatikizidwe ndi mowa, kuphatikiza kwa mowa wa ethyl ndi mankhwala ena a anorexigenic angapangitse kusintha kwa zovuta zomwe zimayambitsa thupi.
• Pa chithandizo chonse, wodwalayo ayenera kuwunika kuchuluka kwa kuthamanga kwa magazi ndi kugunda kwa mtima, komanso kuwunika zomwe zili uric acid ndi lipids m'magazi,
• kugwiritsa ntchito makapisozi, munthu ayenera kusamala makamaka poyendetsa ndikugwira ntchito ndi maukadaulo aukadaulo, monga mankhwalawa angachepetse chidwi chanu,
• mankhwalawa sayenera kumwa nthawi yomweyo ndi mankhwala aliwonse oletsa kuponderezana.

Contraindication ndi zoyipa

Kulandila makapisozi a anorexigenic Meridia imakhudzana ndi matenda komanso zizindikiro monga:

• mavuto amisala (kuphatikizapo anorexia ndi bulimia),
• mankhwala osokoneza bongo
• matenda oopsa
• Prostate adenoma
• matenda a mtima ndi mtsempha wamagazi,
• kulephera kwa aimpso
• lactose tsankho,
• Hypersensitivity pamagawo a mankhwala,
• Kugwiritsa ntchito bwino kwa chiwindi,
• kunenepa kwachilengedwe komwe kumachitika chifukwa cha kusalingana kwa mahomoni, mapangidwe zotupa ndi zina zomwe zimayambitsa,
• kukanika kwambiri kwa chithokomiro.

Kuphatikiza apo, mankhwalawa sayenera kumwedwa ndi amayi panthawi yoyembekezera komanso mkaka wa m`mawere, ana ndi achinyamata osakwana zaka 18, okalamba woposa zaka 65. Mosamala kwambiri, makapisozi ndi ofunikira kwa iwo omwe ali ndi khunyu kapena amakonda magazi.

Anthu omwe akuyesera kuchiza kunenepa kwambiri ndikuchotsa mapaundi owonjezera mothandizidwa ndi Meridia slimming mankhwala amatha kuyang'anizana ndi chitukuko cha zoyipa monga:

• tachycardia
• kukakamizidwa
• nseru
• kudzimbidwa
• kamwa yowuma
• kuphwanya kukoma
• kupweteka m'matumbo ndi m'mimba,
• matenda aikodzo
• kusowa tulo kapena kugona kwambiri,
• mutu
• nthawi zopweteka
• magazi
• utachepa potency
• kupweteka kwa minofu ndi molumikizana
• Khungu loyipa ndi zotupa,
• matupi awo sagwirizana
• kutupa
• kuwonongeka kwa mawonekedwe, ndi zina.

Makanema okhudzana nawo

Ndemanga za madokotala zokhudzana ndi mankhwala ochepetsa Reduxin, Meridia, Sibutramine, Turboslim ndi cellcrystalline cellulose:

Kunenepa kwambiri ndi matenda oopsa, omwe chithandizo chake chimayenera kufikiridwa kwathunthu. Kuti muchepetse kunenepa, munthu amathandizidwa osati kokha mwa kusewera masewera ndi zakudya zoyenera, komanso ndi mankhwala amphamvu. Meridia - mapiritsi azakudya omwe amapereka zabwino, koma ayenera kumangotengedwa pokhapokha akutsimikiziridwa ndi dokotala. Kudzilimbitsa nokha ndi mankhwalawa kumatha kupatsa mphamvu ma kilogalamu komanso kukula kwovuta kwambiri kwa thupi.

• Imakhazikika pamisempha ya shuga kwa nthawi yayitali
• Imabwezeretsa kapangidwe ka insulin

Phunzirani zambiri. Osati mankhwala. ->

Zotsatira za pharmacological

Pharmacological kanthu - anorexigenic.

Njira yothetsera kunenepa. Sibutramine imapereka mphamvu yake mu vivo chifukwa cha metabolites, omwe ndi mabungwe achiwiri komanso oyambira.

Imalepheretsa kubwezeretsanso kwa ma monoamines (makamaka serotonin ndi norepinephrine) ndikuchepetsa chilimbikitso (kumawonjezera kumverera kwodzaza) ndikusintha (kuchuluka kwa mgwirizano wa) pakati pa noradrenergic ndi ntchito za 5-HT ndikuwonjezera ma psychmogenis kudzera mu kukhazikitsa kwina kwa beta3-adrenergic receptors. Zimakhudzanso minofu ya bulauni ya adipose.

Sibutramine ndi ma metabolites ake samatulutsa ma monoamines ndipo si ma MAO inhibitors. Alibe kuyanjana ndi kuchuluka kwa ma neurotransmitter receptors, kuphatikiza serotonergic (5-HT1,5-HT1A, 5-HT1B, 5-HT2a, 5-HT2c), adrenergic (alpha1, alpha2, beta, beta1, beta3), dopaminergic (D1 , D2), muscarinic, histaminergic (H1), benzodiazepine ndi NMDA receptors.

Zisonyezero za mankhwala Meridia

Kusamalira othandizira odwala onenepa kwambiri pazochitika zotsatirazi:

• kunenepa kwambiri kwamankhwala kumakhala ndi index ya 30 kg / m2 kapena kuposerapo,
• Kunenepa kwambiri kwamankhwala ndi chiwindi chachikulu cha 27 kg / m2 kapena kupitirirapo kwa zinthu zina zoopsa chifukwa cha kunenepa kwambiri, monga mtundu 2 shuga mellitus kapena dyslipoproteinemia (kuperewera kwa lipid metabolism).

Mimba komanso kuyamwa

Pa nthawi yoyembekezera, mankhwalawa sayenera kumwa, popeza mpaka pano palibe chiwerengero chokwanira cha maphunziro okhudzana ndi chitetezo cha zotsatira za Meridia pa mwana wosabadwayo.

Amayi a msinkhu wobereka azigwiritsa ntchito mankhwala oletsa kubereka pamene mukumwa mankhwalawo.

Osagwiritsa ntchito Meridia panthawi yochepa.

Kuchita

Kugwiritsa ntchito munthawi yomweyo kwa sibutramine ndi mankhwala omwe amalepheretsa ntchito ya CYP3A4 enzyme (ketoconazole, erythromycin, troleandomycin, cyclosporin) kumawonjezera kuwonjezeka kwa plasma ndende ya sibutramine metabolites komanso kuwonjezeka kwa kugunda kwa mtima mwa 2,5 kumenya pamphindi ndi kuchepa kwakukulu kwa Q5.

Rifampicin, phenytoin, carbamazepine, phenobarbital, dexamethasone ndi macrolide othandizira amatha kuthamangitsa kagayidwe ka sibutramine.

Pogwiritsa ntchito munthawi yomweyo mankhwala omwe amathandizira kuchuluka kwa serotonin neurotransmitter mu plasma ya magazi (kusankha serotonin reuptake inhibitors, sumatriptan, dihydroergotamine, potent analgesics - pentazocine, pethidine, fentanyl, antitussive mankhwala - dextromethorphan), chiwopsezo cha kukula kwa serotonin.

Meridia siyimakhudzanso mphamvu ya njira zakulera za mahomoni. Zambiri pazokhudzana ndi mankhwala zimagwirizana ndi mankhwala omwe amagwiritsidwa ntchito kwakanthawi kochepa.

Ngakhale ndimamwa ndi mowa, palibe kuwonjezeka kwa zotsalazo. Komabe, mowa samaphatikizidwa kwathunthu ndi njira zomwe zingalimbikitsidwe pakudya ma sibutramine.

Zotsatira zoyipa

Nthawi zambiri, mavuto amayambika kumayambiriro kwa mankhwalawa (m'masabata 4 oyamba). Kuwonongeka kwawo komanso kuchuluka kwake kumafooka ndi nthawi. Zotsatira zoyipa nthawi zambiri zimakhala zofatsa komanso zosintha. Njira zowunikira zomwe zimayambitsa mavuto: Nthawi zambiri -> 10%, nthawi zina 1-10%, kawirikawiri 145/90 mm Hg) (onaninso "Njira Zosamala").

Hyperthyroidism (chithokomiro chowonjezeka).

Zowopsa za chiwindi.

Zowopsa zaimpso.

Benign Prostatic hyperplasia (kukula kwa chotupa cha prostate ndikupanga mkodzo wotsalira).

Pheochromocytoma (chotupa cha mahomoni a adrenal gland).

Kukhazikitsidwa kudalira kwama pharmacological, mankhwala osokoneza bongo komanso mowa.

Mimba komanso kuyamwa.

Meridia 15 mg sayenera kugwiritsidwa ntchito mwa ana ndi achinyamata ochepera zaka 18 ndi okalamba opitirira 65 chifukwa chosowa luso lokwanira kuchipatala.

Mlingo ndi makonzedwe

Mkati, makapisozi amayenera kumwedwa m'mawa, osatafuna komanso kumwa madzi ambiri (kapu yamadzi). Mankhwalawa amathanso kumwa pamimba yopanda kanthu kapena kuphatikizidwa ndi chakudya.

Mlingo woyambirira ndi kapisozi 1 wa Meridia 10 mg tsiku lililonse. Odwala omwe samvera bwino kumwa mankhwalawa (mawonekedwewo ndi kuchepa kwa thupi osakwana 2 kg mu masabata 4), malinga ndi kulolera bwino, tsiku lililonse mlingo ungathe kuwonjezeka mpaka 15 mg. Odwala omwe ayankha mosavutikira Meridia 15 mg (chitsimikizo ndi kuchepa kwa thupi zosakwana 2 kg mu masabata 4), chithandizo chinanso ndi mankhwalawa ziyenera kusiyidwa.

Ngati mungadumphe kumwa mankhwala pa 10 kapena 15 mg, simuyenera kumwa kawiri, koma muyenera kupitiriza kumwa mankhwalawo malinga ndi dongosolo lomwe mwakonza. Kuchiza sikuyenera kupitirira kwa miyezi yopitilira 3 kwa odwala omwe samvera bwino chithandizo (kuchepa kwa thupi kochepera 5% ya gawo loyambirira la miyezi 3 yamankhwala). Kuchiza sikuyenera kupitilizidwa ngati, ndi mankhwala ena, pambuyo pakuchepa kwa thupi, wodwalayo akuwonjezera 3 kg kapena kuposerapo. Kutalika kwa mankhwalawa ndi Meridia 10 kapena 15 mg sikuyenera kupitirira chaka chimodzi (deta yakuthandizira ndi chitetezo cha mankhwalawa kwa nthawi yayitali sichikupezeka).

Panthawi ya chithandizo cha Meridia, odwala amalangizidwa kuti asinthe moyo wawo ndi zizolowezi zawo kuti akamaliza kulandira chithandizo amatsimikizira kuti kuchepa kwamphamvu kwa thupi kumakhalabe (ngati zofunika izi sizisungidwa, kuwonjezeka mobwerezabwereza kwa thupi ndi kuchezerana ndi dokotala ndizosapeweka).

Malangizowa panjira yofunsira ntchito ndi Mlingo amawonedwa kuti ndi othandiza mpaka dokotala atakusankhirani mtundu wina wothira mankhwalawo. Kuti mukwaniritse bwino, muyenera kutsatira njira yoyenera yomwe mwalandira.

Bongo

Zambiri pa bongo wa sibutramine ndizochepa. Zizindikiro za mankhwala osokoneza bongo sizidziwika, komabe, kuthekera kwa mawonekedwe owonekera kwambiri azotsatira zoyenera kuyenera kuganizira.

Palibe chithandizo chamankhwala cha mankhwala osokoneza bongo kapena mankhwala enieni. M'pofunika kuchita miyeso yonse yokhazikitsira kupuma, ntchito ya mtima, kuthandizira chizindikiro, kutsekeka kwa m'mimba komanso kugwiritsa ntchito makala olimbitsa. Ndi kuthamanga kwa magazi ndi tachycardia, beta-blockers ikhoza kutumikiridwa.

Njira zopewera kupewa ngozi

Amagwiritsidwa ntchito pokhapokha pofotokozedwa bwino komanso kusamala mwapadera. Upangiri wachipatala woyenera.

Odwala omwe atenga Meridia, ndikofunikira kuyendetsa kuthamanga kwa magazi ndi kugunda kwa mtima. M'miyezi iwiri yoyambirira ya mankhwalawa, magawo amayenera kuwunikiridwa sabata iliyonse, kenako pamwezi. Odwala omwe ali ndi matenda oopsa a kuthamanga kwa magazi (kuthamanga kwa magazi pamwamba pa 145/90 mm Hg), kuwunika maderawa kuyenera kuchitika mosamala ndipo ngati kuli koyenera, nthawi zambiri. Ngati kuthamanga kwa magazi pamankhwala obwereza kawiri kudaposa 145/90 mm Hg. chithandizo chiyenera kuyimitsidwa.

Chenjezo liyenera kugwiritsidwa ntchito nthawi yomweyo limodzi ndi mankhwala omwe amachititsa kuti pakhale nthawi ya QT (astemizole, terfenadine, amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol, cisapride, pimozide, sertindole, triceclic antidepressants), komanso m'malo omwe QT ingawonjezere nyengo. monga hypokalemia ndi hypomagnesemia.

Mukamayang'anira pafupipafupi za momwe wodwalayo akumvera mankhwalawa, chidwi chachikulu chiyenera kulipidwa ku dyspnea, kupweteka pachifuwa ndi kutupa m'miyendo, ngakhale kuti palibe mgwirizano pakati pa kugwiritsa ntchito Meridia ndi chitukuko cha matenda oopsa a pulmonary.

Ndiwosamala kwambiri kwa odwala omwe ali ndi khunyu.

Ndi chisamaliro chapadera, Meridia iyenera kutumizidwa kwa odwala omwe ali ndi vuto la chiwindi chofatsa kuti azikhala wamphamvu (kuwonjezereka kwa kuchuluka kwa sibutramine mu plasma ya magazi ndikotheka).

Popeza kuti metabolites wosakhazikika wa mankhwala amuchotsa impso, mosamala kwambiri, mankhwalawa ayenera kugwiritsidwa ntchito mwa odwala omwe ali ndi vuto laimpso ofatsa kwambiri.

Iyenera kugwiritsidwa ntchito mosamala mu odwala omwe ali ndi mbiri yamagalimoto oyendetsa galimoto kapena mawu a pakamwa (osasunthika a minyewa yolumikizika, komanso kufooka kwa mafupa).

Zomwe zimachitika pakumwa mankhwala osokoneza bongo (kupweteka mutu, kudya kwambiri) ndizosowa. Palibe chidziwitso pakukhudzidwa kwa kusiya kudzipereka kwa matenda, kudzikongoletsa kapena kusokonezeka kwa malingaliro.

Pa chithandizo, simuyenera kumwa mowa chifukwa chofunikira kutsatira zakudya.

Mosamala, amalembedwa nthawi imodzi ndi mankhwala omwe amalimbikitsa kuthamanga kwa magazi ndi kugunda kwa mtima (kuphatikiza mankhwala ogwiritsira ntchito kutsokomola, chifuwa ndi chimfine.

Mankhwala osokoneza bongo omwe amapezeka pakatikati kwamanjenje amatha kuchepetsa ntchito zamaganizidwe, kukumbukira, komanso kuyankha.Ndipo ngakhale kafukufuku sanawone momwe vuto la sibutramine limagwirira ntchitozi, komabe muyenera kusamala popereka mankhwalawo kwa oyendetsa magalimoto ndi anthu omwe ntchito yawo imalumikizana ndi chidwi chochuluka.

Malangizo apadera

Mankhwalawa ayenera kugwiritsidwa ntchito pokhapokha ngati njira zonse zochepetsera kulemera kwa thupi sizothandiza (i., Kuchepetsa thupi ndizosachepera 5 kg kwa miyezi itatu).

Kuchiza kuyenera kuchitika kokha monga gawo la zovuta zovuta kuti muchepetse kulemera kwa thupi moyang'aniridwa ndi dokotala wodziwa ntchito mochizira kunenepa kwambiri. Chithandizo chovuta chimaphatikizanso kusintha kwa zakudya ndi moyo, zomwe zimafunikira kuti pakhale kuchepa kwamphamvu thupi pambuyo pakutha kwa mankhwalawa.

Nthawi ya kumwa mankhwalawa iyenera kukhala yochepa munthawi yake.

Malangizo a Meridia ogwiritsira ntchito, contraindication, mavuto, ndemanga

Mankhwala ochizira kunenepa. Kukonzekera: MERIDIA®

The yogwira mankhwala: sibutramine

Kulembera kwa ATX: A08AA10KFG: Mankhwala ochiritsira a nambala yolembetsera yapakati: P No 012145/01 Tsiku lolembetsa: 02.26.06

Mwini reg. acc.: ABBOTT GmbH & Co. KG

Meridia kumasulidwa mawonekedwe, mankhwala ma CD ndi zikuchokera

Makapisozi olimba a gelatin, okhala ndi thupi lachikaso ndi kapu wamtambo, wokhala ndi "10", zomwe zili m'mabotolo ndi zoyera kapena pafupifupi zoyera, ufa wosasunthika. Makapisozi 1 zisoti.

sibutramine hydrochloride monohydrate 10 mg Othandizira: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigodyne (E132), titanium dioxide (E171), sodium lauryl sulfate, inki (imvi), quinoline chikasu. - matumba otumphuka (2) - mapaketi okhala ndi makatoni. 14 ma PC.

- matumba otumphuka (1) - mapaketi okhala ndi makatoni. 14 ma PC. - matumba otumphuka (2) - mapaketi okhala ndi makatoni. 14 ma PC. - matumba otumphuka (6) - mapaketi a makatoni. Makapisozi a gelatin olimba, okhala ndi thupi loyera komanso kapu wamtambo, wokhala ndi "15", zomwe zili m'mabotolo ndi zoyera kapena pafupifupi zoyera, ufa wosasunthika. Makapisozi 1 zisoti.

sibutramine hydrochloride monohydrate 15 mg Othandizira: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigotine (E132), titanium dioxide (E171), gelatin, sodium lauryl sulfate, inki (imvi), quinoline chikasu. - matumba otumphuka (2) - mapaketi okhala ndi makatoni. 14 ma PC.

- matumba otumphuka (1) - mapaketi okhala ndi makatoni. 14 ma PC. - matumba otumphuka (2) - mapaketi okhala ndi makatoni. 14 ma PC. - matumba a matuza (6) - mapaketi a makatoni.

Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Mankhwala ochizira kunenepa. Sibutramine ndi mankhwala osokoneza bongo ndipo amakhala ndi vivo chifukwa cha metabolites (ma pulamu oyambira ndi sekondale) omwe amalepheretsa kubwezeretsanso kwa monoamines (makamaka serotonin ndi norepinephrine).

Kuwonjezeka kwa zomwe zili mu ma neurotransmitters mu ma synapses kumawonjezera zochitika zapakati pa 5-HT-serotonin ndi adrenergic receptors, zomwe zimapangitsa kuti chiwonetsero chokwanira komanso kutsika kwa kusowa kwa chakudya, komanso kuwonjezereka kwa mafuta.

Pogwiritsa ntchito molakwika 3-adrenergic receptors, sibutramine imagwira minofu ya bulauni ya adipose.

Sibutramine ndi ma metabolites ake sizikhudza kutulutsidwa kwa ma monoamines, osatseka ma MAO, alibe mgwirizano ndi kuchuluka kwa ma neurotransmitter receptors, kuphatikizapo serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), adrenergic (1) , 2, 3, 1, 2), dopamine (D1, D2), muscarinic, histamine (H1), benzodiazepine ndi NMDA receptors.

Mafuta, kugawa, kagayidwe Pambuyo kumwa mankhwala mkati, sibutramine imatengedwa mwachangu kuchokera m'mimba. Nthawi yofikira Cmax ya sibutramine ndi maola 1,2.

Sibutramine ili pafupi kuphatikizidwa kwathunthu m'chiwindi ndi kutenga kwa CYP 3A4 isoenzyme ndikupanga kwa mono- (dismethylsibutramine) ndi mitundu ya di-dismethyl (di-dismethylsibutramine) komanso ma hydroxylation ndi conjugation.

Pambuyo pakamwa kamodzi pakumwa mankhwala pa 15 mg, Cmax M1 ndi M2 ndi 4 ng / ml (3.2-4.8 ng / ml) ndi 6.4 ng / ml (5.6-7.2 ng / ml), motsatana. Kudya ndi chakudya kumawonjezera nthawi kuti mufikire ndikuchepetsa mtengo wa Cmax dismethyl metabolites ndi maola atatu ndi 30%, motero, sizimakhudza phindu la AUC la dismethyl metabolites.

Imafalikira mwachangu komanso mokwanira mu minofu. Mapuloteni omanga kwa sibutramine - 97%, M1 ndi M2 - 94%.

T1 / 2 ya sibutramine - maola 1,1, M1 - 14 maola, M2 - maola 16. Amapukusidwa makamaka ndi impso mu mawonekedwe a metabolites osagwira.

milandu yapadera matenda
Pakulephera kwa impso, magawo akuluakulu a pharmacokinetic (Cmax, T1 / 2 ndi AUC) sasintha kwambiri.

Mlingo ndi njira ya mankhwala

Mlingo umayikidwa payekhapayekha, kutengera kulolerana ndi kuthekera kwachipatala. Mlingo woyambayo ndi 10 mg. Ndi osakwanira (kuchepetsa thupi kuwonda osachepera 2 kg mu 4 milungu), koma malinga ndi kulolera bwino, tsiku lililonse mlingo ungathe kuchuluka mpaka 15 mg.

Ngati, mutatha kuchuluka kwa mankhwalawo, mphamvu ya mankhwalawa imakhalabe yokwanira (kuchepa thupi kwa zosakwana 2 kg mu masabata 4), chithandizo chopitilira sichili bwino. Makapu a Meridia amayenera kumwedwa m'mawa popanda kutafuna komanso kumwa madzi ambiri (kapu yamadzi). Mankhwalawa atha kumwa onse pamimba yopanda kanthu ndikudya.

Kuchiza sikuyenera kupitilizidwa kwa miyezi yopitilira 3 kwa odwala omwe munthawi imeneyi (miyezi 3) sanathe kukwanitsa kuchepa kwa 5% kuchokera mgawo loyambira. Kuchiza sikuyenera kupitilizidwa ngati, kumbuyo kwa chithandizo cha Meridia, pakuchepa kwamphamvu kwa thupi, wodwalayo amawonjezera 3 kg kapena kupitilira apo m'thupi.

Kutalika kwa chithandizo cha Meridia sikuyenera kupitirira zaka 2, chifukwa palibe chidziwitso pakugwiritsa ntchito mankhwalawa kwa nthawi yayitali.

Nthawi zambiri, zoyipa zimachitika kumayambiriro kwa mankhwalawa (mu masabata 4 oyamba). Kuwonongeka kwawo komanso kuchuluka kwake kumafooka ndi nthawi. Zotsatira zoyipa nthawi zambiri zimakhala zofatsa komanso zosinthika. Zotsatira zoyipa, kutengera mphamvu ya ziwalo ndi machitidwe, zimaperekedwa motere: Nthawi zambiri -> 10%, nthawi zina - 1-10%, kawirikawiri -

Mankhwala zochizira kunenepa kwambiri

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Makapisozi gelatin yolimba, yokhala ndi thupi lachikaso ndi kapu ya buluu, yokhala ndi "10", zomwe zili m'mabotolo ndizoyera kapena pafupifupi zoyera, ufa wosasunthika.

Othandizira: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigodyne (E132), titanium dioxide (E171), sodium lauryl sulfate, inki (imvi), quinoline chikasu.

7 ma PC - matumba otumphuka (2) - mapaketi okhala ndi makatoni. 14 ma PC. - matumba otumphuka (1) - mapaketi okhala ndi makatoni. 14 ma PC. - mapepala otumphukira (2) - mapaketi a makatoni.

14 ma PC. - matumba a matuza (6) - mapaketi a makatoni.

Makapisozi gelatin yolimba, yokhala ndi thupi loyera komanso kapu yamtambo, yokhala ndi "15", zomwe zili m'mabotolo ndi zoyera kapena pafupifupi zoyera, ufa wosasunthika.

Othandizira: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigotine (E132), titanium dioxide (E171), gelatin, sodium lauryl sulfate, inki (imvi), quinoline chikasu.

14 ma PC. - mapepala otumphukira (2) - mapaketi a makatoni.

Zimatanthawuza kupondereza chilakolako

Mankhwala a Anorexigenic ndi gulu la zinthu zomwe zimachepetsa chilakolako chokhudza kukhudza kwamkati kwamanjenje. Pali malo achisoni ndi satiety mu ubongo. Mankhwala osokoneza bongo omwe ali mgululi ali ndi mphamvu yolimbikitsa pakubwezeretsa, koma nthawi yomweyo amalepheretsa pakati panjala. Zotsatira zamkati zamanjenje zimachitika kudzera mu kuchuluka kwa serotonin ndi norepinephrine mu hypothalamus. Chifukwa cha izi, kuchepa kwa njala.

Mankhwala a Anorexigenic omwe amachepetsa chilakolako cha thupi amagawika mu ma adrenergic othandizira, othandizira a serotonergic dongosolo ndi othandizira palimodzi.

Contraindication ndi zoyipa

Mankhwala a anorexigenic ayenera kugwiritsidwa ntchito mosamalitsa monga momwe adanenera dokotala, chifukwa mankhwalawa amaperekedwa kwa anthu ena. Odwala omwe sayenera kumwa ndalama za gululi:

• ndi matenda oopsa
• thyrotoxicosis,
• neoplasms yoyipa,
• mbiri yamatenda a mtima kapena sitiroko,
• zolakwika za mtima,
• zovuta zamagazi,
• glaucoma
• khunyu.

Komanso contraindication ndi kusokonezeka kwa m'maganizo ndi njira za pathological mu chapakati mantha dongosolo, chiwindi ndi impso kulephera, kusowa tulo komanso mimba.

Pakakhala kuchuluka kwa mankhwalawa, kufooka, nseru, kusanza, mkamwa wowuma, kutsekula m'mimba, kusokonezeka kwamikodzo, kuyambitsa kukwiya, chizungulire, kuthamanga kwa magazi, kutuluka thukuta kwambiri, kutuluka kwa thupi mwa njira ya urticaria kapena edema ya Quincke.

Zizindikiro zotere zikawoneka, mlingo wa mankhwalawo uyenera kuchepetsedwa. Ngati Zizindikiro sizinasinthe, muyenera kusiya mankhwalawo ndikuwonana ndi dokotala kuti akonze chithandizo.

Mankhwala "Meridia"

Mtengo wa chida ichi ukuwoneka wokongola kwa ambiri. Kupatula apo, ma ruble 700-800 poyerekeza ndimankhwala ena ofanana ndiwotsika mtengo. Mapiritsi awa ndi njira yothandiza yochepetsera kulemera kwa thupi, khalani ndi zotsatira zake mwachangu. Mankhwala ndi a gulu la anorexigenic, amalimbikitsa kumverera kwodzaza. Imalepheretsa kubwezeretsanso kwa serotonin, norepinephrine, dopamine, kuchititsa achire zotsatira za mankhwalawa. Amagwiritsidwa ntchito ngati kunenepa kwambiri popanda kulumikizana ndi matenda, pamaso pa matenda a lipid metabolism ndi mtundu 2 shuga.

"Meridia" imapezeka m'mapiritsi a gelatin a 10 ndi 15 mg, zidutswa 14 mu paketi imodzi. Contraindication kumwa mankhwalawa ndi kuleza mtima kwa gululi, matenda amanjenje ndi amisala, kulephera kwa mahomoni m'thupi, matenda a mtima ndi mitsempha, matenda a impso, chiwindi, chithokomiro.

Mutha kuchepetsa kulemera kwa thupi mwa kutenga 1 kapisozi 10 mg tsiku lililonse. Ngati mankhwalawa akhazikika bwino, mlingo wa tsiku ndi tsiku ungathe kuwonjezeka mpaka 15 mg. Njira ya mankhwala sayenera zosaposa chaka chimodzi. Mapiritsi a Meridia, omwe mtengo wake ndi ma ruble 700 a makapu 14, akhoza kugulidwa ndi mankhwala.

Ichi ndi mankhwala ophatikizidwa omwe nthawi yomweyo amalepheretsa pakatikati pa njala chifukwa cha metabolites ndikuthandizira pakatikati pa machulukidwe. Mankhwalawa amagwiritsidwa ntchito 1 kapisozi patsiku. Mlingowo umaperekedwa palokha, kutengera kuchuluka kwa kunenepa kwambiri komanso kuchuluka kwa thupi. Nthawi zambiri zimakhala 10 mg. Mapiritsi a Reduxin amayenera kudyedwa popanda kutafuna, kutsukidwa ndi madzi ambiri.

Zisonyezero akugwiritsidwa ntchito: kunenepa kwambiri popanda kulumikizana ndi matenda a zam'mimba, pamaso pa matenda a lipid metabolism ndi mtundu 2 shuga.

Mapiritsi a Reduxin sayenera kugwiritsidwa ntchito ndi amayi omwe ali ndi pakati komanso oyembekezera, anthu omwe ali ndi matenda a ziwalo zina. Pankhaniyi, kufunsira kwa katswiri wofunikira kumafunikira. Mankhwala amatchulidwa mogwirizana ndi regimen ndi zakudya tsiku lililonse.

Mankhwala "Fepranon": malangizo ogwiritsira ntchito

Ichi ndi mankhwala a anorexigenic omwe mankhwala ake ndi ampepramone. Imayendetsa gawo lodzala, imalepheretsa pakatikati pa njala, imathandizira kuchotsedwa kwa zinthu zopanda pake ndikuchepetsa thupi. Zochita za mankhwalawa zimadziwonekera pambuyo pa ola limodzi, zimatha kwa maola 8, zimalowa bwino kudzera mu ubongo-wamagazi ndi zotchinga za placental.

Zisonyezero zakugwiritsidwa ntchito kwa mankhwalawa ndi kunenepa kwambiri kwamatumbo komanso kuwonongeka kwa lipid chifukwa cha kusokonekera kwa mahomoni. Ndi matenda a chithokomiro, amagwiritsidwa ntchito limodzi ndi mankhwala a chithokomiro.

Piritsi 1 la mankhwala lili 25 mg yogwira ntchito. Pafupifupi 80 mg amayenera kudyedwa patsiku, ndiye kuti, piritsi limodzi 2-3 kamodzi patsiku. Muyenera kumwa iwo theka la ola musanadye. Kutalika kovomerezeka ndi miyezi iwiri, maphunzirowa atha kubwerezedwa pambuyo pa miyezi itatu. Mankhwalawa amaperekedwa pokhapokha ngati amupatsa mankhwala.

Pankhani ya bongo wa Fepranon, kugunda kwa mtima komanso kupumira, kuyerekezera zinthu zina, ndikugwa. Ngati mumwa mankhwalawa ndi khunyu, mutha kupweteketsa mtima, motero, ngati muli ndi matenda amtunduwu, muyenera kuchepetsa kudya.

Mankhwala "Slimia"

Iyi ndi njira yochepetsera thupi, mankhwala omwe amakwaniritsidwa chifukwa cha yogwira mankhwala sibutramine. Zomwe zimakhudza thupi zimachitika ndikuyambitsa pakati pakukweza, kuchepetsa njala komanso kudya pang'ono. Komanso, mankhwalawa amathandizira kuwonjezera kagayidwe ndikuchotsa mwachangu zinthu zakupha m'thupi.

"Slimia" imagwiritsidwa ntchito kunenepa kwambiri kwamankhwala, kunenepa kwambiri kwa matenda ashuga komanso matenda a lipid metabolism. Mankhwala ndi contraindised mu milandu:

• ndimavuto amanjenje ndi amisala,
• kusokonezeka kwa mahomoni
• matenda a mtima ndi mtima,
• matenda a chiwindi, impso, chithokomiro
• uchidakwa kapena uchidakwa,
• kwa anthu ochepera zaka 18
• azimayi oyembekezera komanso oyembekezera.

Osaloledwa bwino ndi thupi "Slimia". Ndemanga ya kuchepa thupi akuwonetsa kuti mankhwalawa ali ndi zovuta m'magazi, kupweteka mutu, kugona, chizungulire nthawi zambiri kumayambiriro kwa chithandizo. Pamaso pazizindikiro zotere, muyenera kufunsa katswiri wokhudza kusiya mankhwala.

"Slimia" imapezeka m'mapiritsi a 10 ndi 15 mg, mlingo wa mankhwalawa ndi piritsi limodzi patsiku. Njira ya mankhwalawa imayamba ndi 10 mg, ngati zotsatira zake zili zabwino, ndiye kuti muyezo wa mankhwalawa ukhoza kuwonjezeka mpaka 15 mg ndikukwaniritsa zabwino munthawi yochepa.

Pharmacokinetics

Sibutramine imatengeka bwino kwambiri m'mimba ndipo imagwira ntchito kwambiri "yoyamba" kudzera m'chiwindi. Cmax ya mankhwala a m'madzi a m'magazi amawonedwa patatha maola 1,2 kuchokera pakamwa limodzi lokhalo la 20 mg ya sibutramine.

Kugawa komanso kagayidwe

Sibutramine imapangidwa ndi CYP3A4 isoenzyme kuti demethylated metabolites M1 ndi M2. Pharmacologically yogwira metabolites ya M1 ndi M2 ifika Cmax pambuyo maola atatu.

Zinawonetsedwa kuti ma lineet kinetics amachitika pamtunda kuchokera pa 10 mpaka 30 mg, ndipo palibe kusintha komwe amadalira mlingo wa T1 / 2, koma pali kuwonjezeka kwa kuchuluka kwa mankhwalawa m'magazi am'magazi molingana ndi mlingo.

Ndi Mlingo wobwereza wa Css, ma metabolites M1 ndi M2 adakwaniritsidwa patatha masiku 4, ndipo pafupifupi kudziwikiratu kawiri kunawonedwa. Ma pharmacokinetics a sibutramine ndi ma metabolites ake m'magazi onenepa kwambiri ndi ofanana ndi odwala omwe ali ndi thupi labwino.

Kumangidwa kwa sibutramine ndi ma metabolites ake a M1 ndi M2 kwa mapuloteni a plasma kumachitika pamlingo pafupifupi 97%, 94% ndi 94%, motsatana.

Gawo loyamba la excretion ya sibutramine ndi metabolites yake yogwira M1 ndi M2 ndi metabolism mu chiwindi. Ma metabolites ena (osagwira) amathandizidwa ndi impso, komanso matumbo ake mwa kuchuluka kwa 10: 1.

T1 / 2 ya sibutramine ndi maola 1.1, T1 / 2 ya metabolites M1 ndi M2 - maola 14 ndi maola 16, motsatana.

Pharmacokinetics mu milandu yapadera yamankhwala

Zomwe zilipo zochepa zomwe sizikusonyeza kukhalapo kwa kusiyana kwakukulu kwamankhwala mu menacokinetics mwa amuna ndi akazi.

Ma pharmacokinetics omwe amawona odwala okalamba athanzi (pafupifupi zaka 70) ali ofanana ndi odwala achinyamata.

Kulephera kwa renal sikunakhudze AUC yogwira metabolites M1 ndi M2, kupatula metabolite M2 mwa odwala omwe ali ndi vuto laimpso omwe amatsika ndi dialysis.Kuwayika kwawo kwa mankhwala osokoneza bongo kunali pafupifupi kuwirikiza kawiri kuposa kwa anthu athanzi (CL> 80 ml / min).

Odwala omwe ali ndi vuto lochepa la hepatic, AUC yogwira metabolites M1 ndi M2 anali 24% pambuyo patatha gawo limodzi la sibutramine.

- kunenepa kwambiri kwam'mimba ndi index ya thupi (BMI) yama 30 kg / m2 kapena kupitilira apo,

- Kunenepa kwambiri ndi BMI ya 27 kg / m2 kapena kuphatikiza mtundu 2 wa matenda a shuga (osagwirizana ndi insulin) kapena dyslipoproteinemia.

Meridia: Malangizo ogwiritsira ntchito piritsi

Meridia - mapiritsi a zakudya omwe ali ndi sibutramine. Katunduyu amachepetsa m'mimba lipases, kuti mafuta asamatengeke ndikusungidwa m'thupi.

Makapisozi amagwiritsidwa ntchito pofuna kuchiza kunenepa kwambiri kwamaonekedwe aliwonse ndipo amateteza kulemera kwa odwala omwe ali ndi vuto lotha kunenepa kwambiri. Mankhwalawa ndi othandiza kwambiri, chifukwa chake, mankhwalawa amayenera kuyang'aniridwa ndi achipatala.

Kupanga ndi mawonekedwe a kumasulidwa

Meridia amapezeka mu mawonekedwe a capule. Piritsi limodzi lili ndi 10-15 mg ya sibutramine.

Kufotokozera Meridia mu malangizo - makapisozi a gelatin amapanga magawo awiri achikasu ndi amtambo. Mkati mwa piritsi pali ufa woyera.

Zowonjezera za kapisozi kakang'ono ka Meridia:

• E 104
• Ma Ss
• E 171
• E 132
• CMK
• E 572
• E 172
• Shellac
• Propylene glycol
• Shuga wamkaka
• Gelatin
• E 322
• Dimethicone.

Chotupa chimodzi ndi 14 kapena 28 makapisozi. Mapiritsi okhala ndi malangizo amayikidwa pabokosi lamakhadi.

Mankhwala

Sibutramine ndi ufa wamakristali. Poyamba, chipangizochi chinali chopangidwa pochiza matenda amisala, koma kenako adayamba kugwiritsa ntchito mankhwalawa pochotsa kunenepa.

Mankhwala Meridia amakhudza metabolites, monga a sekondale kapena oyambira. Sibutramine imachepetsa kubwezeretsanso kwa ma neurotransmitters, kotero kuti kumakhala kumverera kwanjala komanso kumverera kwachisoni.

The achire zotsatira pambuyo ntchito Meridia zimachitika yomweyo, popeza zigawo zikuluzikulu za mankhwalawa zimakhudza pakati pakudzazidwa mu ubongo. Chifukwa chake pamakhala kumverera kwadzuwa labodza, komwe kumachepetsa kuchuluka kwa chakudya chomwe chimadyedwa.

Mankhwala ena omwe amapezeka ndi mankhwalawa:

• Lowers cholesterol, LDL, uric acid, triglycerides
• Kuchulukitsa kuchuluka kwapachulukidwe lipoprotein
• Ili ndi mphamvu ya anorexigenic.
• Imathandizira kutentha lipids, kuphatikiza mafuta a bulauni
• Zimasintha thermoregulation, chifukwa chomwe lipolysis imakhudzidwa ndipo njira za metabolic zimayambitsa.

Meridia yochepetsa thupi imakhala ndi chinthu china chofunikira - cellcrystalline cellulose. Awa ndi ulusi wopota womwe umagwira ngati sorbent.

MCC imasintha kagayidwe kake, kumatha kudzimbidwa, kumachotsa poizoni m'thupi. Komanso, chinthucho chimadzaza matumbo, omwe amachepetsa njala.

Kusunga mankhwala Meridia

Pamalo ouma, pamtunda wosaposa 25 ° C.

Pewani kufikira ana.

Alumali moyo wa mankhwala Meridia ndi zaka 3.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Meridia - mankhwala ochepetsa thupi, amatanthauza gulu la mankhwalawa omwe amayang'anira kudya. Zimapangidwa ndi kampani yaku Germany ya Knoll AG.

The kapangidwe ndi mphamvu ya mankhwala "Meridia" m'thupi

Meridia amapangidwa pamaziko a chinthu monga sibutramine. Imachepetsa kumverera kwa njala ndipo imayambitsa kukwiya mwachangu, kotero kuti munthu amadya zopatsa mphamvu zochepa. Mwa zina zomwe zimapanga Meridia, pali zinthu monga lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate ndi ena.

Mankhwalawa amapezeka mu mawonekedwe a makapisozi olimba a gelatin okhala ndi thupi lachikaso kapena loyera komanso kapu yamtambo. Zomwe zili m'mabotolo oterewa ndi ufa woyera wopanda magazi. Makapisozi ali ndi 10 mg kapena 15 mg yogwira ntchito. Amapezeka m'matumba a 14 ndi 28 mapiritsi.

Mapiritsi a zakudya a Meridia amakhudzanso malo a ubongo, omwe amachititsa kuti pakhale nthawi yayitali komanso kuti asamasangalale. Kuphatikiza apo, mankhwalawa samangolamulira komanso kuchepetsa chidwi, komanso amathandiza kugaya, amachepetsa cholesterol, komanso amatulutsa njira zonse za metabolic zomwe zimachitika m'thupi la munthu. Ngakhale mutatenga Meridia, thupi liyenera kuwononga mphamvu zambiri, chifukwa chomwenso kumachepa thupi.

Makapisozi a Meridia ali ndi zinthu zabwino motere:

• Popanda kudya mosamalitsa komanso masewera olimbitsa thupi mu masewera olimbitsa thupi, kumwa mankhwalawa kumakuthandizani kuti mutaye pafupifupi 10% ndikusunga zotsatira zake nthawi yayitali.
• Asanawonekere pamasamba apachipatala, mankhwalawa adayeza.
• Kulandila mapiritsi kumadziwika ndi kuphweka komanso kosavuta.
• Makapisozi amavomerezedwa mwalamulo ndikuvomerezedwa kuti azigulitsa ndikugwiritsa ntchito m'maiko opitilira 26.

Kuphatikiza apo, mankhwala a Meridia amagwira pakatikati pa ubongo, kupondaponda chilimbikitso ndi kupititsa patsogolo njira zamagetsi, kumapangitsa njira ya lipolysis, chifukwa chomwe maselo amafuta agawika.

Kuti akwaniritse zochizira zotchulidwa, mankhwalawa amachepetsa Meridia ayenera kumwedwa nthawi yayitali. Malangizowo akuwonetsa kuti mlingo woyambirira wa mankhwalawa uyenera kukhala 10 mg patsiku. Ngati mwezi woyamba kulemera kumatayika bwino - kuposa 2 kg, muyenera kupitiliza kumwa. Mlanduwo ukakhala kuti kulemera kwa thupi kumatsika ndi zosakwana 2 kg m'mwezi woyamba, wopanga akuwonetsa kuti athe kuwonjezera mankhwalawa mpaka 15 mg wa mankhwalawa patsiku.

Njira imodzi yodzichiritsa ndi milungu 4. Ngati mumwa mankhwalawa osakwana miyezi itatu, simatha kuchita zabwino, chifukwa Meridia amayamba kuchita zinthu pang'onopang'ono ndipo ali ndi chikhalidwe chowonjezera. Zotsatira zazikulu zolemetsa zimakwaniritsidwa miyezi isanu ndi umodzi mutayamba makapisozi a Meridia.

Mankhwala ochepetsa a Meridia ali ndi zotsutsana zotsatirazi:

• wazaka 18
• nthawi ya pakati komanso yoyamwitsa,
• zaka zopitilira 65
• aimpso ndi chiwindi kulephera,
• matenda amtima, matenda oopsa, matenda amisala,
• kutenga njira zina zochepetsera thupi.

Mapangidwe angapo a Meridia amadziwika, momwe sibutramine amakhalanso. Zina mwazofanana ndi mankhwala monga Denfluramine, Dexfenfluramine, Fluoxitine.

Zotsatira zoyipa, bongo, kuyanjana

Zotsatira zoyipa pambuyo pa kugwiritsidwa ntchito kwa sibutramine nthawi zambiri zimachitika masiku 30 oyambirira a mankhwala. Monga lamulo, pakatha mwezi umodzi wogwiritsira ntchito mapiritsi, zovuta zoyipa zimangokhala pazokha.

Nthawi zambiri, Meridia amasokoneza chakudya cham'mimba, chomwe chimawonetsedwa ndi kukhumudwa, kutentha kwa mtima, kufalikira kwa zotupa, mseru.

Zotsatira zina zoyipa:

• CNS - migraine, xerostomia, nkhawa, kusokonezeka kwa kugona, dysgeusia, vetrigo
• Integument - zotupa, zotupa, khola, magazi
• Mtima ndi mitsempha ya magazi - matenda oopsa, kutentha kwake, kusokonezeka kwa mtima.

Nthawi zina, Meridia imayambitsa mavuto owopsa omwe amafunikira chithandizo chamankhwala. Zochitika zoterezi zimaphatikizira kulanda, pachimake psychosis, mapangidwe a miyala ya impso, kutsika kwa ma protein, capillarotoxicosis, ndi glomerular nephritis.

Popeza kutenga sibutramine kumakhudzanso zamaganizidwe, kumatha kusintha kukumbukira ndikuthamanga pakuchita, panthawi yayitali ya chithandizo, muyenera kukana kuwongolera magwiridwe antchito kapena mayendedwe.

Mankhwala osokoneza bongo a Meridia sanakhazikitsidwe. Mwina, mukamwa mankhwala ambiri, mankhwalawo amayamba kutchulidwa.

Pankhani ya bongo, mankhwala apadera samachitika. Madokotala amalimbikitsa kuwunikira ntchito ya mtima ndi mtima, kuonetsetsa kupuma kwa wodwala. Ngati ndi kotheka, mutha kutenga kuloweramo, kuchititsa kupweteka kwa m'mimba. Ndi tachycardia kapena matenda oopsa, anthu okhala ndi vuto la beta akhoza kutengedwa.

Mogwirizana ndi Meridia ndi mankhwala ena:

• CYP3A4 enzyme inhibitors - kugunda kwa mtima kumakwera, zomwe zili sibutramine metabolites m'magazi zimachulukitsa, nthawi yayitali ya QT
• Macrolides, glucocorticosteroids, mapiritsi ogona, zinthu zosokoneza, ansamycins, standardolytics, phenytoin - yambitsa metabolism sibutramine
• Olimba mtima painkiller, 3 antidepressants, alpha-blockers, tryptamine zotumphukira - mwayi wa kuledzera wa serotonin ukuwonjezeka.

Ma fanizo odziwika a mankhwala a Meridia ndi Reduxin ndi Goldline.

Wopanga - Ozone, Russia

Mtengo - kuchokera ku 1600 rubles

Kufotokozera - makapisozi amagwiritsidwa ntchito pochiza kunenepa kwambiri ndi BMI ya 30 kg / m2

Ubwino - zimathandizira kuchepa thupi, zimachotsa kumverera kwanjala

Chidwi - zoyipa zimayambira ndikusokonekera, mtengo

Wopanga - Izvarino-Pharma, Russia

Mtengo - kuyambira 1200 mpaka 3500 rubles

Kufotokozera - makapisozi potengera sibutramine ndi MCC amatengedwa chifukwa cha kunenepa kwambiri kuti athetse njala

Ubwino - kulemera kumasiya msanga, kumachepetsa chilakolako, sikuwonjezera,

Chidwi - mtengo, umayambitsa pakamwa pouma komanso mopanda kukhumudwa.

Meridia chilangizo chowongolera: mawonekedwe ndi malingaliro okhudzana ndi kugwiritsa ntchito mankhwalawa

Zakudya zopanda pake komanso kusowa kochita masewera olimbitsa thupi nthawi zonse kumatha kubweretsa kuchuluka kwa kilogalamu ndi kukula kwa kunenepa kwambiri.

Nthawi zina, ndizosatheka kuthana ndi vuto lofananalo mothandizidwa ndi masewera komanso zakudya.

Zikatero, akatswiri azakudya amatenga mankhwala apadera kwa odwala awo kuti achepetse thupi.

Imodzi mwa mankhwalawa ndi Meridia. Akagwiritsidwa ntchito moyenera, mankhwalawa amapereka zotsatira zabwino komanso amathandiza anthu kuti achepetse thupi popanda kuvulaza thanzi.

Zakudya zamankhwala a Meridia okhala ndi sibutramine mu mawonekedwe: akumwa kapena osamwa?

Aliyense amene wayesera kuchepetsa thupi kwa nthawi yayitali amadziwa: zomwe zimathandiza, kenako zimasokoneza thanzi. Ndipo njira zambiri zotetezeka sizothandiza. Chifukwa chake, aliyense ayenera kusankha yekha njira yomwe angasankhe.

Mapiritsi a Meridia, omwe amaphatikiza sibutramine yemweyo, amakupangitsani kuganizira za nkhaniyi. Katunduyu, komwe zopandulitsa zazikulu zakhala zikuwonekera kwa zaka zingapo tsopano. Kodi mumamwa kapena osamwa mankhwalawa kuti mukhale osalala?

Mapiritsi a Meridia amadzaza kabokosi kamakatoni okhala ndi mawonekedwe osasinthika (oyera, mzere wofiyira wonyezimira umakhazikitsidwa pansi). Mutha kupeza opanga osiyanasiyana: mankhwalawa amapangidwa ndi makampani onse aku Russia ndi nkhawa za ku Germany.

Maonekedwe - makapisozi olimba a gelatin: chikasu (kutulutsa kwakukulu kwa 10 mg) kapena koyera (15 mg) thupi lokhala ndi kapu yabuluu. Mkati mwake muli ufa woyera.

Kulongedza mwachizolowezi - zidutswa 14 pachikhodzodzo, matuza awiri mumapaketi 1.

Kuphatikizikako ndikuphatikizapo:

• sibutramine (dzina lolondola ndi hydrochloride monohydrate) amagwira ntchito ngati yogwira ntchito, ena onse amakhala othandizirana,
• sodium lauryl sulfate,
• cellcrystalline mapadi,
• lactose monohydrate,
• colloidal silicon dioxide,
• magnesium wakuba,
• gelatin
• titanium dioxide (E171),
• indigotine (E132),
• imvi
• Utoto wa quinoline wachikasu (E104).

Muyenera kumvetsetsa kuti Meridia ndiwopangidwa, osati mankhwala achilengedwe omwe ali ndi zotsatirapo zonse. Inde, ndi-sibutramine.

Pankhani ya sibutramine. Kuyambira pa Januware 24, 2008, chinthuchi chaphatikizidwa pamndandanda wa mankhwala amphamvu omwe avomerezedwa ndi boma la Russian Federation. Chifukwa chake, kugulitsa ndalama zomwe zili nacho (kuphatikiza Meridia) ndikololedwa kokha chifukwa cha mankhwala (ndi zitsanzo zapadera) komanso m'mafakisi okha.

Zochita pa thupi

Zochita zam'mapiritsi zimadalira psychotropic zotsatira za sibutramine, zomwe zili nazo. Kodi zimachepetsa bwanji kuwonda?

• mankhwala ake apamwamba ndi anorexigenic,
• amachepetsa chilakolako (kumawonjezera kukhuta) ndi kuchuluka kwa chakudya
• kumawonjezera Thermogenesis, chifukwa cha momwe metabolism ndi lipolysis imathandizira,
• zimakhudza minofu yamafuta
• kumawonjezera kuchuluka kwa HDL m'magazi ndikuchepetsa kuchuluka kwa triglycerides, cholesterol, uric acid, LDL.

Malinga ndi ziwerengero, anthu ambiri amakono ndi onenepa kwambiri chifukwa chokhala phee komanso kudya kwambiri. Ndipo pankhaniyi, Meridia ndiye chida chokwanira chochepetsera kunenepa, chomwe chingathandize kuthana ndi zomwe zimayambitsa.

Sibutramine imapereka mauthenga ku ubongo kuti thupi ladzala, safunikiranso kudya. Njala yotsekedwa, ndipo pachakudya chotsatira simudzadya gawo lalikulu, chifukwa simudzafuna.

Zotsatira zimatha kufikira 10 kg pamwezi.

Zizindikiro zakuchipatala za kutenga Meridia ndi izi:

• kunenepa kwambiri (koyambira) kozama ndi minyewa yambiri yoposa 30 kg / m2,
• Kunenepa kwambiri kwamankhwala okhala ndi cholozera cha thupi kuyambira pa 27 kg / m2 ngati kulemera kwambiri kumachitika chifukwa cha kusokonekera kwa lipid metabolism kapena matenda a shuga a II.

Musaiwale kuti mapiritsi ndi mankhwala ndipo amagulitsidwa mosamalitsa m'mafakisi. Mukamaitanitsa Meridia pazinthu zapaintaneti ndikuzitenga nokha, popanda chilolezo cha dokotala, mumakhala ndi udindo pazotsatira zonse zomwe zingachitike.

Mtengo umachokera ku $ 24 mpaka $ 52.

Izi ndizodabwitsa. Mu maphunziro, chifukwa chomwe mu 2010 adayimitsa kugulitsa ndikupanga mankhwala okhala ndi sibutramine (kuphatikiza Meridia), anthu omwe poyamba anali ndi vuto la kukakamiza ndi mtima adatenga nawo mbali. Ndizosadabwitsa kuti panthawi yotsiriza kuyesa, thanzi lawo lidakulirakulira.