Metformin 850: malangizo, ntchito, mtengo, ndemanga

Matenda a shuga ndi matenda oopsa, chifukwa mankhwalawa amagwiritsidwa ntchito mitundu ingapo ya mankhwala, kuphatikiza Novoformin. Mankhwalawa ndi a gulu la Biguanides ndipo cholinga chake ndicholembetsa shuga.

Mankhwalawa amalimbikitsidwa kwa odwala omwe ali ndi matenda a shuga 2 omwe ali onenepa kwambiri ngati chithandizo cha zakudya sichokwanira.

Kuphatikiza apo, Novoformin imakonda kutumikiridwa limodzi ndi jakisoni wa insulin ngati wodwala akuvutika osati kunenepa kwambiri, komanso chifukwa chachiwiri cha insulin.

Mawonekedwe ndi mawonekedwe a mankhwalawa

Novoformin ndi wa gulu la mankhwala a hypoglycemic operekera pakamwa.

Njira yayikulu yoperekera mankhwala ndi mapiritsi oyera ozungulira. Fomu ndi biconvex, kumbali imodzi ya piritsi pali ngozi.

Chofunikira chachikulu cha mankhwalawa ndi metformin hydrochloride. Kutengera ndi ndende, mitundu iwiri ya mapiritsi imapangidwa: 500 mg ya yogwira ndi 850 mg. Omwe amachokera ku mankhwalawa ndi awa:

• polyethylene glycol,
• povidone
• sorbitol
• magnesium wakuba.

Mitundu yosiyanasiyana ya mankhwalawo imasiyananso ndi mtundu wa chipolopolo: amatulutsa mapiritsi ndi mapiritsi a nthawi yayitali, komanso filimu kapena enveloping.

Mankhwala ndi a gulu la Biguanides. Zotsatira zazikulu za Novoformin ndi hypoglycemic, i.e., zimathandiza kuchepetsa kuchuluka kwa shuga m'magazi a m'magazi. Metformin imatha kuchepetsa mapangidwe a glucose mu hepatocytes, amachepetsa mphamvu yokhala ndi glucose. Nthawi yomweyo, mankhwalawa amathandizira kuti shuga azigwiritsidwa ntchito mopitirira muyeso komanso kumva mphamvu ya minyewa ya insulin. Ngakhale izi, Novoformin sikuti imabweretsa mavuto a insulini ndipo samayambitsa zotsatira za hypoglycemic.

Mphamvu ya mankhwalawa imawonetsedwa pang'onopang'ono popanda insulin. Mankhwala atapangidwa ndi mankhwalawo ndi osiyana pang'ono kutengera mawonekedwe ake. Chifukwa chake, mapiritsi wamba amachititsa kuchepa kwa cholesterol, IG ndi LDL. Mankhwala omwe akhala akuchita kwa nthawi yayitali, m'malo mwake, samakhudzanso cholesterol ndi LDL, koma nthawi zina amatha kuwonjezera kuchuluka kwa TG.

Kuphatikiza apo, mankhwalawa amathandizira kukhazikika kwa kulemera kwa odwala omwe ali ndi matenda a shuga, ndipo nthawi zina pamakhala kuchepa pang'ono kwa mafuta m'thupi. Nthawi zambiri amagwiritsidwa ntchito ngati munthu amachepetsa thupi ngakhale pakapezeka kuti ali ndi matenda ashuga.

Kuyamwa kwa mankhwalawa kumachokera m'mimba. The bioavailability wa mlingo wa Novoformin mpaka 60%. Mankhwala amatha kudziunjikira mthupi - makamaka minyewa, impso, chiwindi ndi ma gasi a salivary. Kuzindikira kwakukulu kumatheka pafupifupi maola awiri. Kuchoka kwa mankhwalawa kumachitika mosasinthika kudzera mu impso. Nthawi yochuluka ya theka la yogwira mankhwala ndi maola 6.5

Kuchulukitsa kwa Novoformin ndikotheka, koma nthawi zambiri kumachitika ndi vuto laimpso. Kuchokera mthupi, mankhwalawa amamuchotsa mkodzo.

Malangizo ogwiritsira ntchito mankhwalawa

Musanayambe kumwa mankhwalawa, ndikofunikira kuti muzolowere malangizo a mankhwalawa kuti mugwiritse ntchito Novoformin kuti pasakhale zizindikiro zosasangalatsa mtsogolo.

Malamulo a mankhwala ndi mlingo amatsimikiziridwa payekhapayekha kwa wodwala aliyense. Tengani mapiritsi a 500 mg a yogwira ntchito akulimbikitsidwa kuti ayambe ndi mapiritsi a 1-2 patsiku, ndiye kuti osapitirira 500-1000 mg. Pakupita pafupifupi milungu 1.5-2 pamankhwala, kuchuluka kwa mankhwalawa ndikotheka, ngakhale izi zimadalira kuchuluka kwa shuga m'magazi. Kuti mukhale ndi vutoli, mulingo wambiri wa mapiritsi a 3-4 a Novoformin akulimbikitsidwa, okwanira sayenera kupitilira mapiritsi 6.

Mapiritsi a Novoformin 850 mg amayamba kumwa ndi piritsi limodzi tsiku lililonse. Pambuyo pa masabata 1.5-2, potengera kuchuluka kwa shuga m'magazi, chisankho chimapangidwa pakuwonjezereka kwapang'onopang'ono kwa mlingo. Mlingo wokwanira wa mankhwalawa sayenera kupitirira 2,5 g.

Miyezo imeneyi imalimbikitsidwa kwa achikulire. Kwa okalamba, tikulimbikitsidwa kuchepetsa kuchuluka kwa mapiritsi 2 (osapitirira 1000 mg). Komanso, mlingo umachepetsedwa ndimatenda akulu a metabolic m'thupi.

Ndikofunika kumwa mankhwalawo ndi chakudya kapena mukangodya. Mapiritsi amatha kutsukidwa, koma kuchuluka kwa madzi kuyenera kukhala kochepa. Popeza kuoneka kwa zotsatirapo za mankhwalawa ndizotheka, tikulimbikitsidwa kugawanitsa gawo lonse la tsiku mu magawo omwewo mu Mlingo wa 2-3.

Ngati wodwala watchulidwa mankhwalawa Novoformin limodzi ndi insulin (Mlingo watsiku ndi tsiku wosakwana 40), ndiye kuti mankhwalawo ndi ofanana. Potere, ndizovomerezeka kuti pang'onopang'ono muchepetse mulingo wa insulin, osaposa magawo 8, kamodzi pakapita masiku awiri. Ngati wodwala akukakamizidwa kumwa insulini yoposa 40 ya insulin tsiku lililonse, ndiye kuti kuchepetsa magazi kumavomerezedwanso, koma osavomerezeka kuti azingochita nokha. Nthawi zambiri, kuchepetsa insulini kumachitika mu chipatala, mosamala kwambiri.

Mankhwalawa ali ndi zifukwa zingapo zotsutsana:

1. Matenda a chiwindi, impso.
2. Myocardial infaration mu shuga.
3. Kusalolera payekha kwa metformin kapena zigawo zina za mankhwala.
4. Hyperglycemic chikomokere.
5. Zakudya zama calori zochepa (zama caloric kudya zosakwana 1000 kcal / tsiku).

Kuphatikiza apo, mankhwalawa sanalembedwe masiku awiri asanachitike opaleshoni iliyonse komanso mayeso omwe amasiyana ndi zomwe ayodini amapatsidwa.

Kutsutsana kwa kuperekedwa kwa mankhwala ndi pakati.

Pakukonzekera kutenga pakati, komanso pakati pa mankhwala atangoyamba kumwa, mankhwalawa ndi Novoformin ayenera kusiyidwa.

Ndemanga ndi mtengo wa mankhwalawo

Ndemanga za mankhwala a Novoformin ndi abwino, onse pakati pa madokotala komanso pakati pa odwala. Endocrinologists omwe adasiya ndemanga zawo akuti akhala akuwapatsa mankhwala kwa chaka chopitilira chaka chimodzi. Mankhwala othandiza makamaka amawaganizira odwala omwe ali ndi kunenepa kwambiri (omwe ali ndi BMI yoposa 35). Zimathandizira kuchepa kwamafuta ochulukirapo, ngakhale kuti akwaniritse zomwe zimafunika kutsatira zakudya komanso kuchepetsa kudya komwe kumakhala ndi shuga.

Malinga ndi ndemanga, mankhwalawa a Novoformin ali ochepetsetsa kwambiri pakati pa biguanides. Mankhwalawa amathandizanso kuchepetsa misempha ya m'magazi a plasma. Odwala omwe ali ndi kunenepa kwambiri, chizindikiro ichi chatsika ndi 1.5% osamwa mankhwala ena owonjezera ndi insulin.

Ubwino wa mankhwalawo umaphatikizapo mtengo wake: kutengera mzindawu ndi mankhwala, mankhwalawa amatha kutengera mitundu ya ma ruble 100-130.

Kuphatikiza pa ndemanga zabwino, mankhwalawa adalandira ambiri osalimbikitsa. Odwala ena sanawone kusintha kulikonse, ngakhale atakhala nthawi yayitali. Madokotala ena amagwirizana nawo: amakhulupirira kuti Novoformin ndiwofowoka kwambiri kuposa ma analogues, monga Glucofage kapena Siofor.

Mankhwala othandiza, ma endocrinologists amalangizidwa kuti asankhe mitundu ya mankhwala:

• Metformin (chinthu chachikulu),
• Chikwanje,
• Siofor
• Forin Pliva,
• Sofamet
• Metfogamma.

Odwala ena omwe amamwa mankhwalawa amadandaula za mawonekedwe a mankhwalawa:

• kupweteka kwambiri pamimba
• nseru
• kusowa kwa chakudya
• kuphwanya kwam'mimba,
• ziwengo

Mankhwalawa atha kugulidwa ku pharmacy iliyonse, koma pokhapokha ngati mwalandira ndi dokotala.

Imwani mankhwalawa mosamala mogwirizana ndi malangizo, kupewa bongo.

Kuchulukitsa kuchuluka kofunikira kwa mankhwalawa kumatha kuyambitsa zovuta zina. Chifukwa chake, kumwa mankhwala aliwonse a gulu la biguanide (kuphatikiza Novoformin) kungayambitse lactic acidosis - mkhalidwe wamavuto omwe ungayambitse imfa. Zizindikiro za lactic acidosis ndi kupweteka kwa minofu, chidwi, kugona, kuchepa kwa thupi, komanso nseru.

Ngati zizindikiro zilizonse za lactic acidosis zikuwoneka, ndikofunikira kusiya kumwa Novoformin ndikugoneka m'chipatala mwansanga.

Ndi mankhwala ati omwe angagwiritsidwe ntchito m'malo mwa Noformin a shuga? Izi zidzafotokozedwa mu kanema mu nkhaniyi.

Mlingo ndi mitundu

• Glucophage imapezeka mu mlingo wa 500, 850 ndi 100 mg.
• Mapiritsi a Glucophage Long okhala ndi nthawi yayitali amakhalanso.
• Amawamwa m'magazi pang'onopang'ono kuposa glucophage wokhazikika (500, 750 ndi 1000 mg) ndipo amapezeka mu Mlingo wa 500 ndi 750 mg.

Glucophage imakhala ndi kufanana pakati pa mankhwala osokoneza bongo. Pali ambiri a iwo, koma Siofor, omwe amapangidwa mumtundu wa 500, 850 ndi 1000 mg, komanso Metformin (500 mg) amatchuka kwambiri.

Glucofage ya mankhwala (kapena analogues a Metformin, Siofor), malangizo ogwiritsira ntchito akutsimikiziridwa mu milandu yotsatirayi:

1. - kunenepa kwambiri,
2. - ngati thupi silitha kuzindikira insulin,
3. - zochizira ana odwala matenda ashuga,
4. - zochizira matenda amishuga amtundu wa 2.

Mapindu ake

Glucophage (kapena fanizo la Matformin, Siofor) monga mankhwala ali ndi zovuta zake zosaneneka:

1. - akulimbana ndi matenda a shuga,
2. - wokhoza kuwongolera shuga ndi insulin,
3. - ndiko kupewa matenda am'mimba chifukwa cha cholesterol yotsika,
4. - imasinthasintha kagayidwe ka lipid ndikuchepetsa kuyamwa kwa chakudya.

Contraindication

Malangizo ogwiritsira ntchito alemba maulendo angapo pamene simungathe kugwiritsa ntchito Glucofage (kapena fanizo la Metformin, Siofor):

1. - pamaso pa matenda a impso ndi chiwindi.
2. - ngati mukusowa chimodzi mwazinthuzi,
3. - wodwala matenda ashuga,
4. - Zakudya zamafuta ochepa,
5. - ndi matenda a mtima,
6. - poyizoni wakupha, kuphatikizapo mowa,
7. - anthu opitirira zaka 60 ndi ntchito zolimbitsa thupi,
8. - mimba.

Buku lamalangizo

Ngati mungaganize zotenga Glucofage Long (500, 750 mg) kuti muchepetse kunenepa, ndiye kuti muyenera kutsatira malamulowa:

1. - osapatula chakudya chamagulu ochulukirapo ndi zakudya zomwe zimapangitsa kuchuluka kwa shuga,
2. - menyu yazakudya zomwe ziyenera kukhazikitsidwa ziyenera kuyang'aniridwa, ngati mutadya kamodzi kapena mopitilira muyeso, ndiye kuti Glucofage (500, 850, 1000 mg) yochepetsa kulemera siyingakhale othandiza.
3. Pofanana ndi kugwiritsa ntchito Glucofage Long (500, 750 mg), ndikofunikira kutsatira regimen tsiku ndi tsiku komanso kudya mokwanira, kuwonjezera masewera olimbitsa thupi ndikuchepetsera kumwa kwa mowa ndi chikonga. Zakudya zopatsa thanzi ziyenera kukhala zamtundu wapamwamba ndipo zimakhala ndi fiber yambiri. Chifukwa cha kuchepa mphamvu kwa insulin, chiwindi chimachepetsa glucose, ndipo chinthu ichi sichipinidwa ndi minofu. Glucophage Long imachepetsa njala yomwe insulin imayambitsa.
4. Glucofage wamba amagwiritsidwa ntchito pa 500 mg 1 ora musanadye katatu patsiku. Glucophage Long (750 mg) imamwa kwambiri pang'onopang'ono, motero imagwiritsidwa ntchito piritsi limodzi lokha ndi 750 mg nthawi ya chakudya kapena itatha. Njira yonse yogwiritsidwira ntchito ndi masiku 18-20, ndipo malangizo ogwiritsira ntchito ndikukulangizani kuti mupume kwa miyezi ingapo. Sitikulimbikitsidwa kugwiritsa ntchito Glucofage kuti muchepetse kunenepa kwambiri kuposa nthawi yodziwikiratu, chifukwa ntchito yake imangokhala yopanda ntchito.

Muyenera kusamala ndi bongo wa Glucofage Long, komanso zovuta zina.

Zotsatira zoyipa

1. - kulawa kwazitsulo mkamwa ndikusokoneza zosokoneza,
2. - kusanza, kutsegula m'mimba, kunyansidwa (kutsegula m'mimba n`kotheka ngati, molumikizana ndi kugwiritsa ntchito Glucofage Long, chakudya chovomerezeka cha chakudya chamoto chinaposa),
3. - ziwengo
4. - zovuta kagayidwe kachakudya ndi chiwindi ntchito.

Ndipo tsopano lingalirani za kuwunika kwa madotolo ndikuchepetsa thupi omwe adagwiritsa ntchito Glucofage Long (kapena Siofor) pakuchepetsa thupi. Apa ndipomwe zosangalatsa zimayambira. M'pofunika kuwerenga mosamala zomwe mankhwala a Glucofage akuti: malangizo:

Ndikulimbikitsidwa kugwiritsa ntchito mankhwalawa pokhapokha ngati mukunenepa kwambiri, koma, choyamba, ndi matenda a shuga!

Izi zikutanthauza kuti Glucophage Long (kapena Siofor) sanapangidwe kuti achepetse thupi, koma kuti athandize odwala matenda ashuga.

Zomwe Glucophage Long (kapena Siofor), zingathandizire kuchepa thupi, koma osati kwa aliyense. Kuwerengera akatswiri azakudya zakuwonetsa kuwulula.

Monga tanena kale, Glucophage Long (kapena Siofor) amalepheretsa kuyamwa kwa glucose komanso mayamwidwe am'mimba ndi matumbo. Chifukwa chake, mukatenga Glucofage Kutalika ndikuchita masewera olimbitsa thupi limodzi ndi zakudya, pamakhala kuyaka kwamphamvu kwa mafuta omwe amapezeka kale.

Koma sitiyenera kuiwala kuti kuyamwa kwa glucose m'chiwindi sikungobwera kokha kuchokera kumakanizo obwera, komanso ku amino acid, glycerol, etc.

Mwanjira ina, kwa iwo omwe amakonda kudya nyama yamafuta m'malo mwa mpukutu, Glucofage (kapena Siofor) sangathandize.

Kutenga Glucophage Long kuyenera kuyang'aniridwa ndi madokotala kwathunthu, chifukwa nthawi yochepetsera thupi, zotsatira zoyipa ndi zotsatira zosayenerera zimatha kuchitika.

Malinga ndi ndemanga za anthu omwe adagwiritsa ntchito Glucofage Kutalika kwa thupi, zimayambitsa kusanza, nseru ndi fungo limodzi lokha la chakudya.

Komabe, izi ndi zovuta zochepa chabe zomwe zingachitike mutatenga Glucofage Long (kapena Siofor). Odwala, nthawi zina impso zimasokonezeka, hypoglycemia imadzuka.

Zotsatira zake, adawopsezedwa kuti agonekedwa m'chipatala atatha kudya Glucophage Long (kapena Siofor).

Kodi mtengo wamtengo wotsika kwambiri?

Ndemanga za madokotala amachenjeza kuti kugwiritsa ntchito Glucofage Kutalika kwa thupi ndi anthu athanzi kumatha kubweretsa pachimake pancreatitis.

Ku America, maphunziro adachitika momwe Glucophage adagwiritsidwira ntchito makamaka pofuna kuchepetsa thupi. Zotsatira zake, odwala ambiri atatha kudya Glucofage Long ali ndi matenda a kapamba.

Chifukwa chake, ndibwino kufikira kugwiritsa ntchito mankhwalawa Glucofage mosamala ndikupereka njira iyi kwa adotolo. Musaiwale kuti mukamagwiritsa ntchito mapiritsi a Glucophage kuti muchepetse kunenepa, muyenera kuyesa mayeso nthawi zonse. Chifukwa chake kumwa Glucofage kuti muchepetse thupi, kuphatikiza njirayi ndi ntchito muofesi, ndizokayikitsa kuti zingagwire ntchito. Ngati mungaganize zochepetsa thupi ndi mankhwala, ndibwino kuti mutchuthi.

Glucophage yochepetsa thupi sichosankha chabwino kwambiri, makamaka chifukwa ziyenerabe kuphatikizidwa ndi zakudya komanso masewera olimbitsa thupi. Mwinanso muyenera kugwiritsa ntchito malingaliro omwe omwe amaperekedwa kuti mugwiritse ntchito Glucophage, koma popanda mankhwalawo? Mapeto ake, izi sizikhala zoyipa.

Komanso mudzakhala ndi chidwi ndi:

Garcinia cambogia zitsamba ndi zowonjezera: mitengo ndi kuwunika

Guarana slimming Tingafinye (ndemanga ndi mitengo)

Bisacodyl yoyipa (zowonjezera ndi mapiritsi): mtengo, malangizo ndi malingaliro

Metformin hydrochloride ndi mankhwala omwe amagwiritsidwa ntchito pofunsa, omwe ndi ofunika kwa iwo omwe ali ndi matenda a shuga a 2. Kwa odwala omwe ali ndi vuto lotere, mankhwalawo amathandiza:

• chepetsa magazi am'magazi,
• Tetezani kuti musavulaze mitsempha yamagazi ndi cholesterol yoyipa,
• kuletsa kukula kwa mafuta kuwonda kwamkati,
• kukhala ndi vuto la kufooketsa kwambiri kwa mafuta m'thupi.

Mwa njira, ambiri mwa mavutowa amapezeka mwa anthu onenepa kwambiri, chifukwa chogwiritsa ntchito Metformin pakuchepetsa thupi posachedwa kwakhala kofala kwambiri. Kukhala ndi shuga wambiri m'magazi, zinthu zomwe zimakonzedwazo zimalepheretsa kuyamwa kwa chakudya, ndikulepheretsa mapangidwe a glycogen m'chiwindi.

Zotsatira zake, kuchepa kwa mphamvu kumawonekera m'thupi (monga momwe zimakhalira ndi njala), yomwe iyenera kuthana ndi kugwiritsa ntchito ndalama zambiri.Nthawi yomweyo, mulingo wa shuga m'magazi umakhalabe wokhazikika, ndiye kuti, sutsika kwambiri, womwe umalola munthu kuti asamve njala yayikulu ngakhale m'masiku osala kudya. Komabe, ndikulakwitsa kukhulupirira kuti Metformin imakhala ngati wowotchera mafuta mukamachepetsa thupi, ndipo zonse zomwe sizimveka zimasungunuka pamaso pathu.

Mukangoyamba kumwa mankhwalawa, mphamvu ya maselo kuti insulin iwonjezeke, yomwe imayang'anira metabolism ya carbohydrate ndi chilimbikitso chofuna kudya. Chifukwa chake kugwiritsa ntchito Metformin ndikuti simungakhale wanjala, ndipo mafuta amthupi m'malo ovuta a thupi amayamba kuchepa.

Malangizo ogwiritsira ntchito

Zowonetsa mwachindunji pakugwiritsa ntchito Metformin (matenda ashuga) zikusonyeza njira yoyenera yoperekera malangizo omwe angagwiritsidwe ntchito. Komabe, anthu athanzi omwe adaganiza kukonza mankhwalawa ndi mapiritsi awa ayenera kutsatira malamulo angapo omwe amawateteza ku zovuta zomwe zimamwa mankhwalawa:

1. Kutalika kwa nthawi yolandila sikupitilira miyezi itatu.
2. Imwani piritsi limodzi kapena mutangodya.
3. Mlingo wa tsiku ndi tsiku ndi mapiritsi atatu.
4. Voliyumu ya tsiku ndi tsiku yaufulu wamafuta uyenera kukhala pafupifupi 30 ml pa 1 kg ya kulemera.
5. Palibe chifukwa chomwe simuphatikiza kutenga Metformin ndi kusala komanso kumwa mowa.
6. Ndikofunika kutsatira zakudya zomwe zimaphatikizapo kuletsa kwambiri kugwiritsa ntchito zakudya zamafuta ndi maswiti. Izi sizofunikira kuti muwonjezere mphamvu ya mankhwalawa, koma kuti mupewe zotsatira zoyipa kuchokera m'mimba ndi matumbo.

Monga lamulo, mavuto obwera chifukwa cha mseru, kusowa kwa chakudya, mawonekedwe a mchere wamkamwa amaphatikizana ndi masiku oyamba a prima Metformin kuti achepetse thupi. Pakadutsa masabata awiri, ngati simutsatira malamulo omwe ali pamwambapa, mavuto azakudya zam'mimba (kutsegula m'mimba, kupindika komanso kupweteka kwam'mimba, kupangika kwa mpweya) kumatha kuyamba, komwe kumakupangitsani mwayi woti muchoke m'chipinda chogona nthawi yayitali. Ngati mukukumana ndi mavuto osokoneza mankhwalawa, muyenera kuchepetsa kuchuluka kwake.

Tisaiwale kuti m'thupi la munthu wathanzi, njira zonse zamankhwala amuzolengedwa zimayenda mosiyanasiyana, kuti muchepetse kunenepa, mankhwalawa amaloledwa kugwiritsidwa ntchito kwakanthawi kochepa pokhapokha atakambilana ndi katswiri wazakudya. Masiku ano, mankhwalawa amagulitsa zithunzi zambiri za mapiritsi a Metformin - Glucofage, Siofor, Glycon, Formetin, Bagomet, ndi zina. Zonsezi zimapezeka mosiyanasiyana, motero ndikosavuta kwa munthu wosazindikira kusokonezeka ndimomwe angagwiritsire ntchito komanso momwe angagwiritsire ntchito. Metformin yochepetsa thupi ndi: pakati komanso nthawi yoyamwitsa, matenda a impso, mtima, chiwindi, ndulu. Osakaniza kuphatikiza mankhwalawa ndi mankhwala komanso zowonjezera pazakudya, zomwe zimakhala ndi mankhwala othandizira kapena okodzetsa. Kupanda kutero, mutha kuyambitsa impso kwambiri.

Katya, wazaka 29. Pazomwe mungatenge Metformin kuti muchepetse kunenepa, ndinaphunzira kwa mnzake. Anali ndi mavuto akulu okhala ndi kunenepa kwambiri, zomwe zinali zokhudzana mwachindunji chifukwa sakanatha kuyendetsa kudya kwake pankhani ya chakudya komanso zakudya zotsekemera. Mwa njira, sanali kudwala matenda ashuga. Chiwerengero changa sichinakhale chomvetsa chisoni kwambiri, koma ndidaganiza zoyesabe. Ndidatenga mlingo wa 500 mg ndikumwa mapiritsi awiri patsiku. Zotsatira zoyipa zinali (kugona, kufooka, kutopa, mseru pang'ono). Mwina izi ndichifukwa choti poyamba ndinadula kwambiri zopatsa mphamvu za zakudya zanga. Kenako ndinayamba kudya moyenera. Pambuyo pa miyezi itatu, ndinatha kutaya 7 kg. Pomwe mtsikanayo adamwa mapiritsiwo kwa miyezi 6, pomwe adatha kutaya 16 kg.

Marina, wazaka 34. Mukamamwa Metformin, chidwi chake chimachepera. Izi ndizowona makamaka kwa dzino lokoma ngati ine. Zowona, sindinasinthire mwachangu kuchakudya cholondola, motero ndinapeza zovuta m'matumbo (komanso ndimatumbo oyenda nthawi zonse). Mwezi woyamba kumwa mankhwalawa, adanditenga makilogalamu 3.1. Tsopano ndayamba kale kunena kuti sindikufuna kudya kwambiri, kotero popanda kuvutika ndinayamba kudya. Ndidikirira zotsatira zina.

Svetlana, wa zaka 32. Ndinalinso ndi zovuta, koma osati nthawi yomweyo, koma kwinakwake patatha pafupifupi milungu itatu. Osanena kuti zimandivutitsa kwambiri, choncho sindinachepetse mulingo wa mankhwalawo. Ndidafunitsitsadi kuchepetsa thupi mwachangu. Ndipo, "mbali yotsatira" posakhalitsa idapita, zonse zidayamba kukhala zabwinobwino. Ndamwa Metformin miyezi 2,5 kale, mzere wa plumb wafika kale pa 4 kg.

Mapilogalamu Ogulitsa Zakudya Azilankhula 02/08/2016

Kuchepetsa thupi

Zokhudza Mapiritsi a Zakudya

Kuwunikira kwamavidiyo: Mkazi wokondweretsa ... momveka bwino komanso osangalatsa! Sindinafune kumwa mankhwala ndi tiyi, ndipo pambuyo pa vidiyoyi sindikufuna kutero!

Zakudya zodziwika kwambiri zamafuta:

• Kremlin
• Banana
• Zamasamba
• Mphesa
• Buckwheat
• Green
• Ginger
• Kabichi
• Mbatata
• Kefir
• Wachichaina
• Ndimu
• Nyama
• Zamasamba
• Oatmeal
• Mpunga
• Selari
• Msuzi
• Tchizi tchizi
• Dzungu
• Zakudya zomanga thupi
• Chifalansa
• Nyemba
• Chocolate
• Apple
• Dzira
• Chijapani

Zowonjezera, maofesi, ndi zina.

Mankhwala ambiri ochepetsa thupi, popanda mankhwala, simugulitsa mankhwala aliwonse. Inde, ndipo inunso popanda malingaliro a katswiri simuyenera kuwagwiritsa ntchito. China china ndi maumboni amakono omwe amapangidwa ndi zinthu zachilengedwe. Pansipa pali mankhwala omwe amagulitsa kwambiri pamsika wa CIS.

Onsewa ndi maloboti ochepera, okhala ndi zomwe wopanga akunena ndipo ali ndi tanthauzo lenileni. Koma, popanda njira yolumikizidwa, sangathandize.

1. Zowonjezera Zachilengedwe
2. Mankhwala Ovuta a Anorexigenic
3. Kukonzekera kwa microcellulose
4. Zothandiza ndi zodyetsa thupi pakuchepetsa thupi
5. Hormonal slimming mankhwala
6. CHIKWANGWANI cha kuwonda
7. Ndi dokotala uti kuti muthane naye kuti muchepetse kunenepa?

Masiku ano, mankhwala ambiri amapangidwa, kutsatsa kwa aliyense kumalonjeza zotsatira zabwino kwa wogula ndi zotsatira zoyipa zochepa. Koma mwatsoka, zonse sizabwino, monga Dr. House anati, "aliyense amanama" (c).

Ngati mwayesapo mapiritsi aliwonse ndipo mukuyenera kuti muuze, siyani ndemanga pansipa. Zidzakhala zosangalatsa komanso zothandiza kwa aliyense, ngakhale madokotala.

Ngati mukudziwa za kukonzekera bwino, tilembereni kapena pansipa mu ndemanga, tidzakusonyezani muyeso lathu.

Kutulutsa mawonekedwe ndi kapangidwe kake

Metformin Richter imapezeka m'mapiritsi ozungulira kapena ozungulira. Zomwe zimagwira mwa iwo ndi metformin hydrochloride. Zowonjezera zina, kapangidwe kake kamaphatikizira kopovidone ndi povidone, filler microcrystalline cellulose ndi magnesium stearate, chovala choyera cha filimu Opadry.

Pachikhalidwe, wopanga amapanga mankhwalawa mumitundu iwiri - 500 ndi 850 mg. Miyezi ingapo yapitayo Metformin-Richter 1000 adalembedwanso, yomwe imapangidwira odwala matenda ashuga omwe ali ndi vuto lalikulu la insulin, ndipo, motero, mlingo waukulu wa tsiku ndi tsiku wa mankhwalawo. Posachedwa, akuyembekezeka kupezeka mgulu lachipatala.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

Matenda a shuga ndi omwe amayambitsa pafupifupi 80% yonse yamikwingwirima ndi kuduladula. Anthu 7 mwa anthu 10 amafa chifukwa cha mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chomaliza chomaliza ndi chimodzimodzi - shuga wamwazi.

Shuga akhoza ndipo ayenera kugwetsedwa; Koma izi sizichiritsa matendawa, koma zimangothandiza kulimbana ndi kufufuza, osati zomwe zimayambitsa matendawa.

Mankhwala okhawo omwe amalimbikitsidwa mwalamulo kwa odwala matenda ashuga komanso ogwiritsidwa ntchito ndi endocrinologists pantchito yawo ndi Ji Dao shuga patch.

Kugwiritsa ntchito bwino kwa mankhwalawa, kuwerengera malinga ndi njira yokhazikika (kuchuluka kwa odwala omwe achiwonjezere kuchuluka kwa odwala omwe ali mgulu la anthu 100 omwe adachitiridwa chithandizo):

• Matenda a shuga - 95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu - 90%
• Kutumiza kuthamanga kwa magazi - 92%
• Vigor masana, kugona bwino usiku - 97%

Opanga Ji Dao si bungwe lazamalonda ndipo amalipiridwa ndi boma. Chifukwa chake, tsopano wokhala aliyense ali ndi mwayi wopeza mankhwalawo kuchotsera 50%.

Mtengo wa mankhwalawa ndi wotsika: 200-265 rubles. mapiritsi 60. M'malo ambiri ogulitsa mankhwala, zitha kugulidwa popanda mankhwala. Kuti mulandire mankhwalawa kwaulere, wodwala matenda a shuga ayenera kulembetsedwa ndi endocrinologist.

Tcherani khutu! Mu mankhwala omwe dokotala wakupatsani, ndi mankhwala okhawo omwe amapezeka - metformin omwe akuwonetsedwa. Mu pharmacy, mutha kupatsidwa osati Metformin-Richter, komanso analogue iliyonse yomwe ilipo.

Moyo wa alumali Metformin-Richter 500 ndi zaka 850 - 3, mapiritsi a 1000 mg amatha kusungidwa zaka 2.

Kodi mankhwalawa amagwira ntchito bwanji?

Metformin ndiye mankhwala akuluakulu omwe amathandizidwa ndi odwala matenda ashuga nthawi yomweyo komanso moyo wonse. Cholinga chakudzipereka kwa madotolo ku mankhwalawa chagona motere:

1. Metformin ili ndi mphamvu yayikulu kwambiri yoyerekeza ndi sulfonylureas. Cholinga chake chimathandiza kuchepetsa hemoglobin wa glycated ndi 1.5%. Zotsatira zabwino zimawonedwa mu onenepa kwambiri a shuga.
2. Mankhwalawa amaphatikizidwa pamodzi ndi mankhwala ena omwe amaperekedwa kwa matenda ashuga. Mankhwala awiri ndi atatu omwe amapezeka ndi metformin amatha kukwaniritsa kuwongolera kwa odwala a shuga.
3. Mankhwalawa ali ndi katundu wamtima wapadera. Zimatsimikiziridwa kuti kutenga izo kumachepetsa chiopsezo cha kugunda kwa mtima, kumapangitsa magazi kuyenda bwino.
4. Metformin ndi imodzi mwamankhwala otetezeka kwambiri odwala. Sichimayambitsa hypoglycemia, mavuto ena owopsa amalembedwa kawirikawiri.

Kutsitsa kwa shuga kwa Metformin-Richter ndi chifukwa cha magwiridwe antchito angapo, palibe omwe amakhudza mwachindunji kapangidwe ka insulin. Atamwa mapiritsi, kupanga glucose ndi chiwindi kumachepetsa nthawi yomweyo, kayendedwe kake kupita ku minofu kumayenda bwino chifukwa chakuchepa kwa insulin. Malangizo ogwiritsira ntchito onani kuti zotsatira zowonjezereka za metformin zimathandizira kusintha kwa chiwongolero cha matenda ashuga - zimachepetsa kuyamwa kwa chakudya cham'mimba, ndi kuchepa kwa chilimbikitso. Malinga ndi ndemanga, izi zitha kuchititsa kuti njira yochepetsera thupi ishuga.

Zizindikiro zogwiritsidwa ntchito

Pakuwunika kwa madotolo, metformin nthawi zambiri imatchedwa maziko othandizira odwala matenda amtundu wa 2. Maupangiri azachipatala apadziko lonse ndi aku Russia agwirizana kwathunthu ndi mawu awa. Njira zochiritsira zikusintha, mankhwala atsopano ndi njira zodziwonera zikuwonekera, koma malo a metformin amakhalabe osasunthika.

1. Onse odwala matenda ashuga omwe kupatsirana kwa zakudya sikungapatse glycemia.
2. Atangozindikira matenda ashuga, ngati mayesowo adawonetsa kukana kwambiri kwa insulin. Itha kuganiziridwa mwa odwala omwe ali ndi kulemera kwakukulu.
3. Monga gawo la chithandizo cha odwala matenda ashuga omwe ali ndi matenda atali.
4. Ndi shuga wodalira insulin, kuti muchepetse mlingo wa insulin.
5. Odwala omwe ali ndi metabolic syndrome, prediabetes monga kuwonjezera kwa kusintha kwa moyo.
6. Anthu omwe ali ndi kunenepa kwambiri komanso ali pachiwopsezo chachikulu cha matenda ashuga. Pochepetsa kukana insulini, Metformin Richter amathandizira kudya.

Pakadali pano, pali umboni wa kuthekera kogwiritsa ntchito mankhwalawa kwa mazira a polycystic ndi chiwindi cha steatosis, koma izi sizinaphatikizidwe pazomwe zimayankhidwa.

Zosasangalatsa zotsatira za metformin

Choyimira chachikulu cha metformin chimakhudzana ndi mphamvu yake pakadutsa chakudya kudzera m'mimba ndi mphamvu ya matumbo aang'ono, momwe njira zazikulu za kugaya zimachitikira. Matendawa sakhala owopsa ku thanzi, koma amakulitsa kwambiri kulekerera kwa mankhwalawa ndikuwonjezera kuchuluka kwa omwe akukana chithandizo chifukwa cha thanzi labwino la odwala.

Chidwi: M'malo mwake momwe muli matenda a shuga mumapereka chilema

Zotsatira zoyipa zam'mimba m'matumbo poyambira chithandizo ndi Metformin-Richter zimawonedwa mu 25% ya odwala matenda ashuga. Amatha kuwonetsedwa m'mphuno ndi kutsekemera kwazitsulo pakamwa pamimba yopanda kanthu, kusanza, kutsekula m'mimba. Zosafunikira izi zimadalira mlingo, ndiye kuti, zimakula nthawi imodzi ndi kuwonjezeka kwa mlingo. Pakatha milungu ingapo, m'mimba mumasinthasintha metformin, ambiri amayamba kufooka kapena kutha.

Kuwunika kwa odwala matenda ashuga kumawonetsa kuti kumwa mapiritsi nthawi yomweyo ngati chakudya cholimba kumathandizira kuchepetsa zizindikiritso, kugawa mlingo wa tsiku ndi tsiku Mlingo 3, ndikuwonjezera pang'onopang'ono Mlingo kuyambira kuyambira wocheperako (500, pazipita 850 mg).

Komanso, mukamatenga Metformin-Richter mwa odwala omwe ali ndi matenda ashuga, khungu lawo siligwirizana, kuwonongeka kwakanthawi kochepa komanso kuchepa kwa chiwindi kungawonedwe. Chiwopsezo chawo chimayesedwa ngati chosowa kwambiri (mpaka 0.01%).

Zotsatira zoyipa zokhazokha za metformin ndi lactic acidosis. Kuthekera kwake ndi milandu itatu mwa odwala 100,000. Kuti mupewe lactic acidosis, muyenera kutsatira malangizo ogwiritsira ntchito, musamwe mankhwalawa ngati pali contraindication, musapitirire mlingo womwe wapatsidwa.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga mankhwala omwe amachiritsa odwala matenda ashuga mellitus. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga amatha kuzipeza February 17 - Kwa ma ruble 147 okha!

>> ONANINSO ZABWINO POPHUNZITSANI CHITSANZO

Momwe mungatenge Metformin Richter

Mlingo wa Metformin uyenera kusankhidwa pawokha kwa aliyense wodwala matenda ashuga. Panthawi yosankha, malangizowo akutsimikiza kuti miyezo ya shuga iyenera kumwedwa pafupipafupi.

Momwe mungadziwe kuchuluka kwake:

1. Mlingo woyambira umatengedwa piritsi limodzi la Metformin-Richter 500 kapena 850. Masabata awiri oyamba sakukonzedwa. Mapiritsi amatengedwa mukatha kudya.
2. Ngati palibe zovuta zoyipa, mlingo umachulukitsidwa ndi 500 kapena 850 mg pakapita milungu iwiri iliyonse. Mapiritsi agawidwa pawiri, kenaka mumagawo atatu. Momwe mlingo umakulira, shuga woyamba amasala kudya, kenako shuga.
3. Mlingo woyenera ndi 2000 mg. Kuwonjezeka kwinanso kwa mapiritsi kumayendera limodzi ndi kuchepa kwambiri kwa glycemia poyerekeza ndi koyambirira.
4. Mulingo wovomerezeka wa metformin tsiku lililonse ndi 3000 mg, pamatenda a impso - 1000 mg, muubwana - 2000 mg.

Kodi chinthu chogwira ntchito Metformin ndi chiani?

Wogwira mankhwala metformin (dzina ladziko lonse lapansi - pln) ndiye chida chachikulu pa mapiritsi osiyanasiyana, omwe nthawi zambiri amalembedwa kwa odwala omwe amapezeka ndi matenda osokoneza bongo. Awa ndi mankhwala a hypoglycemic ochokera ku gulu la Biguanides a m'badwo wachitatu.

Mankhwala a hypoglycemic amalepheretsa njira ya gluconeogeneis, kayendedwe ka ma elekitrodi aulere mu kupumitsa kwa mitochondria.

Metformin imapangitsa chidwi cha machitidwe a glycolysis, maselo amayamba kuyamwa magazi mwachangu komanso mokulira. Mankhwalawa amathandizira kuchepetsa kuyamwa kwa shuga kuchokera ku lumen yogaya chakudya m'magazi a m'magazi. Mankhwalawa samayambitsa kuchepa kwakukulu pamlingo wamafuta m'magazi am'magazi, chifukwa alibe mphamvu yothandizira pazomwe amapanga insulin.

Kapangidwe ka zomwe zimagwira thupi la munthu ndikuwonetsa zotsatirazi:

1. Amachepetsa kuchepa kwa glycogen kuchokera ku chiwalo monga chiwindi. Zotsatira zake, kuwonjezeka koyambira m'magazi a glucose amawonedwa.
2. Imachepetsa njira ya kaphatikizidwe ka shuga wama protein ndi lipids.
3. Moyenerera kumapangitsa kutsika kwa shuga mu chiwindi.
4. Zimathandizira kuchepetsa mawonekedwe a insulin kukaniza ndikukulitsa chidwi cha maselo ndi minyewa ku timadzi timeneti, timene timapangidwa ndi kapamba.
5. Mwabwino amachepetsa mayamwidwe m'matumbo.
6. Zimalimbikitsa kutembenuka kwa glucose kuti agwiritse ntchito m'mimba.
7. Kuchulukitsa lipids yamagazi. Kuphatikiza apo, nthawi yomweyo pali kuchepa kwa cholesterol yoyipa mthupi.
8. Amakakamiza minofu kuti itenge shuga wambiri.

Kukonzekera ndi metformin kuli ndi mwayi umodzi wosayerekezeka poyerekeza ndi mankhwala ena - sizitsogolera pakukula kwa hypoglycemia, ndiko kuti, kuchuluka kwa mafuta m'magazi sikutsika pang'onopang'ono polemba zizindikiro.

Malangizo ogwiritsira ntchito mankhwala aliwonse a Metformin amawonetsa kuti sikuti kungokhala ndi shuga kokha kungakhale chidziwitso chovomerezeka. Mapiritsi amatha kuthandizidwanso pazinthu zotere:

• ngati pali kuphwanya kwa kulolerana kwa glucose kapena mavuto a glycemia amapezeka pambuyo podzuka,
• ndikupanga insulin kukana komanso kuwonjezeka kwakukulu kwa kulemera (makamaka pamimba) ꓼ
• Gynecology imagwiritsa ntchito mankhwala a metformin kuchiza ovarian cleopolycystosisꓼ
• pa kuwonetsedwa kwa metabolic syndromeꓼ
• monga prophylactic popewa kukalamba.

Chosakaniza chophatikizacho chimakhudza ubongo ndipo chimachepetsa chiopsezo chokhala ndi matenda a Alzheimer's.

Kodi mayina ogulitsa mankhwalawa ndi ati?

Mankhwala okhala ndi metformin m'mafakitala amaperekedwa mokwanira. Makampani amakono opanga mankhwala ndi opanga amapanga mitundu ingapo yamitundu mitundu. Itha kukhala mapiritsi kapena makapisozi.

Gulu la mankhwalawa limaphatikizapo mitundu yosiyanasiyana yamankhwala.

Mankhwala oyamba ndi Metformin Teva. Mapiritsi oterewa, akhoza kukhala ndi magalamu 0,5 mpaka 1.0 a yogwira ntchito. Kutengera ndi kudwala kwa matendawa, dokotala yemwe amakupatsani mankhwala amakupatsani mankhwala ochepetsa mphamvu ya metformin hydrochloride. Kupanga ndi kugwiritsa ntchito bwino mapiritsi ndi udindo wa wopanga Israeli. Metformin Teva ndi mankhwala okhala ndi hypoglycemic effect. Amasankhidwa kuti apange shuga wachiwiri. Kuphatikiza apo, kuwonjezera pamankhwala omwe amapezeka nthawi zonse, mapiritsi amatha kuperekedwa m'njira ngati metformin yotulutsidwa. Mtengo wa mankhwalawa umatengera kuchuluka kwa mankhwala omwe ali m'gulu la mapiritsi. Mtengo wapakati, kutengera mtundu wa gawo lomwe limagwiritsidwa ntchito popanga chipangizo chachipatala, limasiyana ndi ma ruble a 77 mpaka 280.

Metformin Canon ndi woimira wa mankhwala achilendo ku Russia. Wopanga wake ndi Russian pharmacological bizinesi Canonfarm Production. Mapiritsi a kapisozi a mankhwalawa, 500, 850 kapena 1000 mg ya mankhwala othandizira atha kukhala. Mankhwala amagwira ntchito ngati hypoglycemic, komanso amathandizanso kuteteza kulemera kwakukulu, makamaka ndi mankhwala. Metformin Canon imakhazikitsidwa bwino pamsika wama pharmacological. Mtengo wake umakhala wotsika kwambiri ndipo umasiyana ndi ma ruble 89 mpaka 130, kutengera mlingo womwe ukufunika.

Metformin Zentiva ndi woyimira mtengo kwambiri wa gulu lotere la kuchepetsa shuga. Mtengo wa mankhwalawa ukhoza kukhala kuchokera ku ruble 118 mpaka 200. Wopangayo ndi kampani ya ku Slovak, yomwe imapatsa ogula mankhwala mankhwala otsatirawa - 0,5, 0,85 kapena 1 gramu ya zinthu zomwe zimagwira. Monga lamulo, Metformin Zentiva amalembedwa kuti achulukitse kuchuluka kwa chakudya m'magazi, komanso ngati pali insulin kukaniza odwala omwe ali ndi zaka zosaposa khumi.

Metformin Richter ndi imodzi mwazofanizira za metformin yopangidwa ndi imodzi mwa makampani opanga awiriwo. Komwe kuli kampani yopanga zamankhwala ndi Russian Federation ndi Hungary. Kuphatikizika kwa mankhwalawa kumaphatikizapo 500 mpaka 1000 mg ya mankhwala othandizira. Limagwirira ntchito ya metformin umalimbana ndikuchotsa hyperglycemia ndi kuphatikiza kulemera kwakukulu.

Nthawi zambiri mankhwalawa amatchulidwa kuti alowe m'malo mwa mankhwalawo. Mtengo wa mankhwalawa umachokera ku ma ruble a 180 mpaka 235.

Mapiritsi okhala ndi Metformin hydrochloride nthawi zambiri amalembedwa zizindikiro zoyambirira za shuga zikawoneka.

Mlingo woyambirira wa mankhwalawa sayenera kupitirira 0,5 magalamu a mankhwala othandizira. Dokotala yemwe akupezekapo angakulimbikitseni kumwa mapiritsi pakudya kapena mutatha kudya, kutengera zosowa za wodwala. Kuchuluka kwa Mlingo wa mankhwalawa sikuyenera kupitilira kawiri kapena katatu patsiku. Pakangotha ​​sabata imodzi kapena iwiri kuchokera pomwe njira yochiritsira isanayambike, kuunikanso kwa Mlingo wokhazikitsidwa kumaloledwa mmwamba. Mlingo wambiri womwe ungatheke tsiku lililonse suyenera kupitirira magalamu awiri a chinthu chomwe chikugwira ntchito. Tiyenera kudziwa kuti ngati mugwiritsa ntchito mankhwalawa musanayambe kudya, ndiye kuti zochita za zomwe zimagwira zimatha kuchepa kwambiri. Nthawi zina, metformin imaphatikizidwa ndi jakisoni wa insulin. Chifukwa chake, kuchuluka kwa jakisoni kumakwaniritsidwa.

Ku Metformin, pharmacokinetics akuwonetsa kuti mankhwalawa, atayamwa pakamwa, amatha kuchuluka kwa plasma patatha pafupifupi maola awiri ndi theka.

Madzi a yogwira pophika amayima patatha maola asanu ndi limodzi atatha kugwiritsa ntchito mapiritsi.

Ma fanizo odziwika kwambiri a Metformin ndi Siofor ndi Glucofage.

Nchiyani chingalowe m'malo mwa mapiritsi a Metformin? Ndi mankhwala ati a pharmacy omwe amadziwika kwambiri pakati pa ogula?

Chimodzi mwazomwe amadziwika kwambiri ndi gulu la Biguanide ndi Siofor, yomwe imapangidwa piritsi. Chofunikira chachikulu cha mankhwalawo ndi metformin hydrochloride, ndipo silicon dioxide, povidone, magnesium stearate, ndi macrogol amagwiritsidwa ntchito ngati zida zothandizira.

Siofor 1000 yodwala matenda a shuga imagwiritsidwa ntchito kuchepetsa magazi. Nthawi yomweyo, kuchepa kwa zizindikiro kumachitika osati pambuyo pa chakudya chachikulu, komanso kumakupatsani mwayi kuti muchepetse maziko. Chofunikira chachikulu mu Siofor chimakupatsani mwayi wopanga ma insulin ndi kapamba, omwe amakhudza thupi bwino komanso samatulutsa chiwopsezo cha hypoglycemia.

Zizindikiro zazikulu zomwe Siofor amatchulidwa ndi matenda a shuga a mtundu wachiwiri, omwe samayendera limodzi ndi insulin. Mphamvu ya Siofor imawonekeranso bwino ndi kusakhazikika kwa mankhwala othandizira.

Gawo lomwe limagwira, lomwe ndi gawo lake, limadziwonetsa kuti likuchepetsa kuyamwa kwa glucose m'matumbo ang'onoang'ono, ndikuchepetsa mphamvu yake yopanga maselo a chiwindi.

Glucophage ndi ofanana kapangidwe kake ndipo ndi chinthu chotengera metformin hydrochloride. Mpaka pano, mutha kugula mapiritsi azomwe mumakonda kapena nthawi yayitali. Kafukufuku wa zamankhwala wasonyeza kuti kumwa mapiritsi a glucophage kawiri kawiri kumabweretsa zotsatira zoyipa kuchokera ku ziwalo zam'mimba.

Nthawi yomweyo, mtengo wa Glucofage Long ndiwotsika kwambiri kuposa zomwe makompyuta ena amakonzekera.

Momwe mungasinthire metformin? Funso ili lingabuke mwa munthu aliyense wodwala matenda ashuga. Masiku ano, pali mankhwala opitilira zana omwe ali amtundu wofanana kapena generic analogues.

Zitha kuphatikizira metformin hydrochloride, monga chinthu chachikulu, kapena kukhala imodzi mwazo (kuphatikiza mankhwala). Zoyambira zimaperekedwa ngati mitundu yotsika mtengo kapena yotsika mtengo ya mapiritsi. Kusiyana kwa mtengo kumadalira wopanga kapena mlingo wa mankhwalawo.

Mayina odziwika kwambiri a mankhwala ofanana:

Zomwe zili zoyenera kwa wodwalayo zitha kungosankhidwa ndi katswiri yemwe akuwongolera matenda ake.

Mwachitsanzo, Glformin ndi woimira kalasi yayikulu, yomwe imaphatikizapo metformin hydrochloride. Zofanana zokhudzana ndi momwe zimakhudzira thupi zimafotokozedwa ndikuti kapangidwe kake kamakhala ndi zinthu zomwezi. Glyformin amalimbikitsa kukondowanso kowonjezera kwa insulin chifukwa cha maselo a beta, komanso zimakhudza kugwiritsidwa ntchito kwazowonjezera kwa kuchuluka kwa shuga ndi minofu.

Ngati mutenga Glformin ndi mankhwala ena a hypoglycemic nthawi yomweyo, zotsatira zake pakuchepetsa misempha ya magazi kumawonjezeka.

Kodi pali kusiyana m'njira ndi chinthu chimodzi chogwira ntchito?

Nthawi zina mutha kupeza ndemanga za odwala kuti kugwiritsa ntchito ma Metformin sikubweretsa zotsatira zabwino. Ena amayamba kuwonetsa zochita zosiyanasiyana. Tisaiwale kuti lingaliro la kufunika kochotsa mankhwalawa liyenera kuchokera kwa dokotala, kutengera mtundu wa chitukuko cha matenda, komanso mikhalidwe ya wodwalayo. Ichi ndichifukwa chake sikuli bwino kufunafuna mosavomerezeka mankhwala omwe ali m'gulu la mankhwala ofanana ndi dokotala.

Kuphatikiza apo, zida zosiyanasiyana zamankhwala zingakhale ndi chinthu chimodzi chogwira ntchito, koma zimasiyana pakapangidwe kazida zamagetsi othandizira. Ndizowonjezera izi zomwe zingayambitse kuvulaza thupi ndikupanga zovuta.

Ndiye chifukwa chake, malingaliro a akatswiri amadzinamiza mpaka akuti mankhwala a analog amatha m'malo mwa mankhwala akuluakulu pokhapokha ngati lingaliro la adokotala likupita. Monga lamulo, mukamayamba kumwa mankhwala ena, kusapezeka kwa zotsatirapo zabwino kumachitika ngati malamulo olondola kapena a piritsi sakusungidwa ndipo ngati pali kuphwanya zakudya.

Mankhwala omwe angagwiritsidwe ntchito kwa odwala matenda ashuga afotokozeredwa ndi katswiri mu kanema munkhaniyi.

Metformin ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda a shuga, prediabetes, mafuta a chiwindi hepatosis ndi zina zomwe zimapangitsa kuti insulin ikane. Mankhwala amakhala ndi mtengo wotsika, koma nthawi zina amafunika kugwiritsa ntchito fanizo la Metformin. Zimafunikira ngati mankhwalawo sanakwane ndi wodwala kapena alibe mphamvu yokwanira panthawi ya mankhwala.

Metformin amatanthauza mankhwala a hypoglycemic. Chombocho chitha kugulidwa mu mawonekedwe a piritsi (500 mg, 850 mg, 1000 mg). Mtengo wa mankhwalawa ndi 93 - 465 rubles. Yogwira ntchito ya mankhwala ndi metformin hydrochloride.

Mankhwalawa amachepetsa gluconeogeneis, amachepetsa kaphatikizidwe ka mafuta acids, ndipo amalepheretsa makulidwe a oxidation a mafuta mamolekyulu. Mankhwalawa amatha kuwonjezera chidwi cha insulin receptors yomwe ili pamphepete. Chidachi chimalimbikitsa kugwiritsa ntchito mamolekyulu a shuga. Mankhwalawa samakhudzana ndi kuchuluka kwa insulin ya magazi, koma amatha kusintha ma hemodynamics a mamolekyulu a insulin.

Mankhwala amawonjezera mapangidwe a glycogen. Potengera momwe mankhwalawo amathandizira, mphamvu yaomwe amanyamula mamolekyulu a shuga amawonjezeka, ndipo kuchuluka kwa kulowerera kwa glucose kudzera khoma lamatumbo kumachepa. Chiwerengero cha mamolekyulu a lipid amachepetsa. Kulemera kwa wodwalayo kumachepetsedwa kapena kukhazikika.

Malinga ndi malangizo, mankhwalawa amagwiritsidwa ntchito pochiza odwala matenda ashuga. Mankhwalawa amagwiritsidwa ntchito ngati zakudya ndi masewera olimbitsa thupi sizithandiza. Kwa akulu, mankhwalawa amatha kugwiritsidwa ntchito ndi mankhwala ena omwe amachepetsa shuga m'magazi, komanso ndi insulin. Mu ana, Metformin amalembedwa kuyambira azaka 10 ngati mankhwala okhawo a hypoglycemic kapena kuphatikiza ndi kuyambitsa insulin.

Zoletsa pazifukwa za mankhwalawa:

• metabolic acidosis
• chikomokere, precomatosis, ketoacidosis mu matenda ashuga,
• kukanika kwa impso
• matenda oopsa opatsirana,
• machitidwe a hypoxic (mtima wamitsempha, kusintha kwa kupuma),
• kulongedza kwakanthawi kwamayendedwe okhala ndi ayodini okonzekera kupimidwa kwa x-ray ndi kulinganiza bwino zochitika,
• poizoni
• matupi awo sagwirizana ndi metformin.

Mankhwalawa amagwiritsidwa ntchito mosamala odwala okalamba omwe ali ndi zaka zopitilira 60 omwe akuchita zolemetsa zolimbitsa thupi (zotheka ndi lactic acidosis). Metformin imalembedwa mosamala kwa amayi oyamwitsa ndi odwala wazaka 10-12. Mosamala yikani mankhwalawa odwala omwe ali ndi matenda a impso.

Zotsatira za Metformin sizikudziwika kwathunthu mukamagwiritsa ntchito odwala omwe ali ndi pakati. Pali umboni kuti mankhwalawa samakulitsa chiwopsezo chokhala ndi zolakwika mwa mwana. Mukakhala ndi pakati kapena kukonzekera, mankhwala ake ndibwino kusiya, kuti musawononge thupi la mayi ndi mwana.

Mankhwalawa sayenera kutumikiridwa limodzi ndi mankhwala okhala ndi ayodini. Palibenso chifukwa chosakanikirana ndi Metformin ndi mowa. Kugwiritsa ntchito munthawi yomweyo mankhwala omwe ali ndi mahomoni a glucocorticosteroid, mankhwala okodzetsa, Danazole, Chlorpromazine, mankhwala opanikizika, β2-adrenergic agonists ndi njira zina osavomerezeka.

Mankhwalawa sangathe kugwiritsidwa ntchito pawokha, chifukwa ali ndi zotsatira zosafunika zambiri. Mukamagwiritsa ntchito mankhwalawa, lactic acidosis, kuchepa kwa magazi m'thupi kumatheka (kuchepa mayamwidwe a vit. B12). Odwala adawona kusintha pamalingaliro, kukoma, dyspepsia, chifuwa (khungu,), kuchuluka kwa michere ya chiwindi, kukula kwa chiwindi.

Pogwiritsa ntchito mlingo waukulu wa mankhwalawa, lactic acidosis ndiyotheka. Wodwalayo ali ndi vuto la kupuma, kugona, kukomoka, kuchepa kwa kuthamanga komanso kutentha kwa thupi, kuchepa pafupipafupi kwa phokoso. Minofu kukokana ndi chikumbumtima chitha kupezeka.

Zizindikiro za lactic acidosis zikawoneka, wodwala amafunikira kuchipatala mwachangu. Izi zitha kusiya zizindikiro za lactic acidosis. Kuchotsa zizindikiro za bongo, hemodialysis imachitidwa.

Mankhwala ofanana ndi Metformin amagwiritsidwa ntchito ngati Metformin ndi yokwera mtengo kwambiri kwa wodwala winawake kapena sagwirizana ndi wodwalayo. Ngati chifukwa chosinthira mankhwalawo ndi mtengo, ndiye kuti ndibwino kuyang'ana analogi. Ngati mankhwalawo sakugwirizana, ndiye kuti analogue yopanda mawonekedwe nthawi zambiri imayikidwa.

Chiwerengero cha mankhwala ofanana ndi chachikulu. Ambiri aiwo ali ndi mawonekedwe ofanana. Mtengo wa mankhwala umatha kusiyanasiyana, koma pang'ono.

Metformin ili ndi ma analogu (ofunikira):

Metformin ndi analogues zimagwiritsidwa ntchito ngati njira yowonjezera, yovuta ya mtundu 1 ndi mtundu 2 wa shuga, kunenepa kwambiri.

Amagwiritsidwa ntchito pazochita zachipatala.

A mawonekedwe a mankhwala ndi kuthekera kuchepetsa shuga popanda kusangalatsa kupanga insulin, yomwe imalepheretsa kupezeka kwa hypoglycemia.

Gawo logwira la mankhwala a hypoglycemic ndi mawonekedwe ake ndi metformin. Pazinthu zothandizira za piritsi la mankhwalawa, mankhwala a magnesium stearate, wowuma, talc amagwiritsidwa ntchito. Mankhwalawa ndi a gulu la Biguanides.

The pharmacological zotsatira ndi zoletsa shuga - mapangidwe a glucose chifukwa cha kagayidwe kachakudya njira mu chiwindi. Mankhwala amachepetsa mayamwidwe am'mimba m'matumbo, amalimbikitsa kugwiritsidwa ntchito kwa shuga.Amachepetsa kuthekera kwa hypoglycemia ndi hyperinsulinemia, amathandizira kukhazikika, ndikulepheretsa kukula kwa mtima pathologies (diabetesic angiopathy).

Zochita za metformin sizikhudzanso kupanga kwa insulin ndipo sizipangitsa kuti pakhale chinsinsi. Mankhwala amachepetsa zomwe zimakhala ndi lipoprotein m'magazi. Katunduyu amagwiritsidwa ntchito pochotsa kunenepa kwambiri.

• matenda ashuga ketoacidosis,
• Mimba, kuyamwa,
• zaka za ana
• aimpso ndi chiwindi kulephera,
• malungo
• vuto la mtima
• uchidakwa.

Mitundu ya Metformin ndi mankhwala osokoneza bongo amadziwika pamodzi ndi insulin. Mlingo umatsimikiziridwa ndi payekha pakuthandizira endocrinologist. Mlingo woyambitsidwa woyamba ndi 500 mg / tsiku (piritsi 1).

Makalata ochokera kwa Owerenga

Agogo anga akhala akudwala matenda a shuga kwa nthawi yayitali (mtundu 2), koma posachedwa zovuta zapezeka m'miyendo ndi ziwalo zamkati.

Mwangozi ndidapeza nkhani pa intaneti yomwe idapulumutsa moyo wanga. Zinali zovuta kuti ndione chizunzo, ndipo fungo loipa m'chipindacho linali kundiyambitsa misala.

Kupyolela pa zamankhwala, agogo aja adasinthanso momwe akumvera. Ananenanso kuti miyendo yake sikupweteka komanso zilonda zake sizinayende; sabata yamawa tidzapita ku ofesi ya dotolo. Falitsa ulalo wa nkhaniyo

Muzochita zamankhwala, onse mankhwala oyambira Metformin, ma analogi ake, ndi ma generic opanga pamtengo wotsika mtengo amagwiritsidwa ntchito:

• Metformin-Teva (wopangidwa ku Israeli). Mankhwala enieni mu mawonekedwe apiritsi. Mtengo - kuchokera ku ma ruble 80.
• Metaformin Long (ntchito yayitali).
• Metformin-Richter (mankhwala aku Russia). Mtengo kuchokera ku 180 rub.
• Metformin-Zentiva (mankhwala a kampani ya mankhwala ku Slovak). Mtengo kuchokera pa 120 rub.
• Metformin-Kanon (wopangidwa ndi kampani yaku Russia ya zamankhwala yotchedwa Kanonfarma Production). Mankhwalawa amapezeka m'mapiritsi. Mtengo wotsika - kuchokera ku ma ruble 90.

Ma analogu a Metformin ali ndi chinthu chogwiritsidwa ntchito pa mlingo wa 500 mpaka 1000 mg. Mankhwalawa ali ndi zochizira zofanana.

Momwe mungasungire shuga kukhala wabwinobwino mu 2019

Metamorphine Long ndiwabwino m'njira yoti njira zochizira matendawa zimatenga nthawi yayitali poyerekeza ndi mankhwala achilengedwe omwe ali mgululi.

Kukonzekera kwa pharmac okhala ndi mawonekedwe osiyana, koma okhala ndi vuto lofanananso ndi mankhwala, amatchedwa ma analogues. Kampani iti, yomwe ndi yabwino kuchokera pazofanizira za Metformin, idzatsimikizidwe ndi adokotala. Mankhwala osiyanasiyana a hypoglycemic ali pamsika.

Ma fanizo odziwika bwino a Metformin ndi awa:

Kuti muthane ndi vuto la kulowetsamo metamorphine, kufunikira kwa zovuta zoyambitsidwa ndi zigawo zothandizira za mankhwala ziyenera kukumbukiridwa. Ma analogs ndi ma synophms amasiyana pama kapangidwe kosiyanasiyana ka zinthu zowonjezera ndi zotumphukira za mapiritsi ndi makapisozi.

Pali kuthekera kwa kusintha kwa zinthu zina mukamatenga Metformin. Pankhaniyi, muyenera kulumikizana ndi dokotala-endocrinologist.

Mukamasankha mankhwala a hypoglycemic, munthu sayenera kuyang'ana kwambiri pamtengo;

Mankhwala a hypoglycemic, omwe ndi amodzi ofunikira kwambiri a Metformin. Amapereka kuchepa kwa basal glucose. Zimalimbikitsa kukhathamira kwa glucose pogwiritsa ntchito minofu. Amachepetsa kuyamwa kwa chakudya cham'mimba.

Siofor 1000 imalimbikitsa kaphatikizidwe ndi kudziunjikira kwa glycogen m'maselo a chiwindi. Amasintha kagayidwe ka lipid. Amagwiritsidwa ntchito kuti achepetse kunenepa kwambiri. Imakhazikika mkhalidwe wa odwala omwe ali ndi matenda a shuga a 2.

Siofor 1000 imapezeka mu piritsi la 1000 mg yogwira ntchito, mu 60 ma PC. pamtengo wa ma ruble 369. Siofor 500 ndi Siofor 850 amapangidwa ndi mitundu yoyenera ya metformin 500 mg ndi 850 mg.

Kuchepetsa shuga ku France kuchokera ku gulu la mankhwala a Metformin analogues.

Timapereka kuchotsera kwa owerenga tsamba lathu!

Amagwiritsidwa ntchito pochiza matenda a shuga. Zisakhudze kuchuluka kwa glucose mwa anthu omwe amakhala ndi chakudya chambiri chama metabolism. Amapezeka mu 1000 mg m'mapiritsi a 60 zidutswa. Mtengo - 322 rub. Glucophage Long imakhala ndi 500 mg, 750 mg, 1000 mg ya metformin. Imakhala nthawi yayitali ya mankhwala.

Mankhwala apiritsi a Russia opangidwa ndi hypoglycemic effect.

Zilibe mphamvu mwachindunji pakupanga insulin. Amachepetsa ndende ya triglycerides ndi lipoproteins zovulaza. Amachepetsa mafuta m'thupi. Amawongolera kuchuluka kwa insulin yomangidwa komanso yaulere. Wolemba Akrikhin OJSC. 500 mg, 850 mg, mapiritsi a 1000 mg. Mtengo wake umachokera ku ma ruble 120.

Mankhwala ophatikizika a hypoglycemic (opangidwa ku Argentina). Kuphatikiza pa metformin, ili ndi glibenclamide yogwira.

Mankhwala amachepetsa kuchuluka kwa shuga m'magazi seramu. Imayambitsa kagayidwe kazakudya, imalepheretsa kupanga shuga m'chiwindi ndikutulutsa kwa chakudya m'magazi. Mosangalatsa zimakhudza kagayidwe ka lipid.

Glibenclamide, mosiyana ndi metformin, imakhudza kugwira ntchito kwa maselo otulutsa insulin, amathandizira zochitika zawo zachinsinsi.

Bagomet imapezeka m'mapiritsi a 850 mg (60 phukusi lililonse) pamtengo wa 136 rubles.

Oral hypoglycemic mankhwala. Amapezeka ngati mapiritsi okhala ndi interic.

Endocrinologists awona kuchuluka kwa zopempha za matenda ashuga.

Vutoli limachulukirachulukira ndikusowa kwa chakudya, komwe kumasokoneza kagayidwe kazakudya. Mankhwala ochepetsa shuga a magazi amathandiza odwala kukhazikika. Kuchokera kwa othandizira a hypoglycemic, madokotala amapatula Metaformin ndi ma analogues, omwe ali ndi chofanana ndi achire.

Olga Dmitrievna (endocrinologist)

Metformin adatsimikizira kuti ndi woyenera kwambiri kuthandizira matenda a carbohydrate metabolism kwa odwala omwe ali ndi matenda osokoneza bongo. Ndiwothandiza makamaka koyambirira kwa chitukuko cha matenda a zamitsempha. Zimaphatikizidwa ndi mankhwala othandizira odwala matenda ashuga. Mwa minus, kupezeka kwa vuto la m'matumbo ngati zotsatira zoyipa titha kuzindikira. Pali tsankho lililonse pazamankhwala.

Konstantin Leonidovich (wazakudya)

Anformate a Metformin agwiritsidwa ntchito kukonza ndikuchepetsa thupi pochotsa kunenepa kwambiri. Zinali zotheka kukwaniritsa zabwino pamankhwala. Koma panali zovuta zina. Odwala adadandaula ndi mseru, kutsekula m'mimba, kumatulutsa. Chilichonse chamadya chinatheratu, chisangalalo chikukula.

Matenda a 2 a shuga amakupatsani mwayi wogwira ntchito, koma amachepetsa moyo. Odwala amakakamizidwa kumwa mankhwala amoyo wonse. Milandu yakuchira kwathunthu kwa matendawa ndiyosowa. Chithandizo cha mankhwala amatha kupititsa patsogolo mkhalidwe wa odwala pamlingo wovomerezeka.

Veronika Sergeevna (wodwala matenda ashuga kwa zaka zoposa 20)

Ndine wonenepa kwambiri. Kulemera kuposa 100 kg. Sanayembekezere chozizwitsa kuti atenge Metformin. Kulemera kwake komwe kunkakhala 34 kg, ndiye kuti kunayamba kuchepa pang'onopang'ono. Nthawi ndi nthawi, kutsegula m'mimba kumachitika. Koma zotsatira zake ndizochepa. Kuphatikizanso ndikuti mankhwalawa ndiokwera mtengo. Shuga akhoza kuchepetsedwa. Vutoli nthawi zambiri limakhala labwinoko kuposa mapiritsi amenewa.

Potsatira lingaliro la dotolo, adayamba kumwa Metformin kuti achepetse thupi. Ndingonena kuti ngati panali chifukwa chomwa mapiritsi awa, ndiye kuti ndikosafunika kwenikweni. Sindinazindikire momwe zimakhalira. Ndikudziwa kuti kuwonjezera pa mapiritsi, muyenera kudya zakudya ndikukhala olimba. Kenako zidzatha kuthana ndi vuto la mapaundi owonjezera.

Metformin, kuphatikizapo ma analogues angapo, amagwiritsidwa ntchito pochita endocrinological kuti apititse patsogolo odwala omwe ali ndi matenda a shuga. Amagwiritsidwanso ntchito mu gynecology pochiza ma cystic misa komanso kuwonda kunenepa kwambiri. Mankhwalawa akuwonetsa zotsatira zabwino zochizira. Mtengo wotsika wa ma analogu ena umakwanira chifukwa cha zovuta.

Matenda a shuga nthawi zonse amayambitsa zovuta zakupha. Mwazi wamagazi ochulukirapo ndi woopsa kwambiri.

A Alexander Myasnikov mu Disembala 2018 adapereka chidziwitso chokhudza chithandizo cha matenda ashuga. Werengani kwathunthu

Zomwe zidzalowe m'malo mwa Metformin mtsogolo: analogues kapena mankhwala atsopano a PPAR-gamma receptors

Wolemba Alla pa Julayi 14, 2017. Yolembedwa mu News News

Mankhwala atsopano a matenda a shuga a 2 amatha kusintha metformin ndi kufananiza kwake mtsogolo.

Mpaka pano, mankhwala omwe amawakonda kwambiri mu mankhwala a shuga ndi metformin.

Ma analogu a Metformin ndi Metformax, Siofor, Glucophage, ndi ena otero. Kuchita kwake ngati wothandizira antidiabetes kumadalira kwenikweni pakukulitsa kwa shuga, kusintha kwa insulini komanso kuletsa kupangira shuga.

Mankhwala atsopano opangidwa ndi asayansi ochokera ku Yunivesite ya Adelaide amakhudzanso kuchuluka kwa maselo, omwe amafanana ndi khungu limodzi m'thupi la munthu. Funso ndilakuti: kodi m'badwo watsopano wamankhwala ungathandize bwanji mamiliyoni a odwala omwe ali ndi matenda ashuga padziko lonse lapansi omwe chithandizo cha mankhwala omwe alipo sichokwanira kapena ndi chothandiza?

Ofufuza ochokera ku Yunivesite ya Adelaide saleka kuyesa kupeza njira zatsopano zopangira matenda ashuga a 2. Alinganize kubweretsa mtundu watsopano wa mankhwala, omwe samangokhala ndi mavuto omwe anali kale ndi mankhwala omwe amagwiritsidwa ntchito kale, komanso amachititsa kuchepetsa majakisidwe a insulin. Woyang'anira Kafukufuku Dr. John Bruening akuti mayeso angapo omwe achitidwa adayankha funso loti asinthe bwanji mankhwala atsopano kuti akhale othandiza komanso otetezeka kuposa mankhwala omwe amagwiritsidwa ntchito masiku ano.

Posachedwa, Journal of the Medical Encyclopedia ndi General BBA inafalitsa maphunziro awiri ofotokoza njira zomwe mbadwo watsopano wamankhwala ungakhalepo mtsogolo pochiza matenda ashuga.

PPAR-gamma receptor ndi udindo wake pakulamulira kwa glycemic

Ofufuzira ku Australia, mogwirizana ndi asayansi ochokera ku bungwe la maHTML ku Florida, akwaniritsa kukhazikitsa mapulani ake mothandizadi. Pa siteji yoyesera, panali mtundu wina wa mankhwala womwe umakhudza ma PPAR gamma receptors omwe amapezeka minofu ya adipose, ndikuyamba kwawo kwathunthu kapena pang'ono.

Izi, zimabweretsa kuwonjezeka kwa insulin sensitivity, ndipo, chifukwa, kutsika kwamagazi a shuga. Kutengera makina awa, "mitundu" khumi ndi inayi ya yogwira ntchito INT-131 idapangidwa, ntchito yomwe ndiko kuyambitsa kwakanthawi kwa receptor iyi. Kusokonekera kwa PPAR-gamma kosakwanira kumeneku kunali kogwira mtima komanso kopanda zotsatirapo zambiri kuposa kuyambitsa kwathunthu.

Mayeso awonetsanso kuti madera omwe amathandizidwira mankhwalawa ndiofunikira kwambiri pakulimbikitsa ma PPAR gamma receptors ndikuwasankha mosankha. INT-131 pano ikukumana ndi mayesero azachipatala ku United States, kuwonetsa kuti ikuyenera kugwiritsidwa ntchito pamlingo wokulirapo mtsogolomo.

Kugwiritsa ntchito makina a PPAR a gamma receptor activation si malo okhawo omwe ofufuza akufuna kugwiritsa ntchito popanga mbadwo watsopano wa mankhwala antidiabetes. Malinga ndi ofufuza ku School of Medical University of Oblomki, rivoglitazone, chinthu chomwe chimatha kumangiriza ku PPAR receptor, chimathandizanso kuchita mbali iyi, potero ikukhudza kuyendetsa magazi.

Ngakhale rivoglitazone imayambitsa kuyika kwake kwathunthu, ilinso ndi zotsatira zoyipa, monga zinthu zina zomwe zili ndi makina ofanana. Pogwiritsa ntchito X-ray crystallography, ofufuzawo adathanso kupanga mapuloteni owoneka bwino ndikuwonetsetsa momwe rivoglitazone imagwirizanirana ndi PPAR gamma. Dr. Rajapaksha, wapampando wa ofufuza ku Flinders University, akuti kumvetsetsa kulumikizana pakati pa chinthu chimodzi ndi cholandilira ndikofunikira kuti pakhale mankhwala atsopano, ogwira ntchito, komanso otetezeka omwe ali bwino mwachilengedwe kuposa metformin.

Ngati mankhwala amakono othandizira amadutsa pamagawo onse oyeserera ndipo akuwonekera pamsika, izi zitha kukhala njira yabwino ku metformin yogwiritsidwa ntchito. Chifukwa amachita zinthu molekyu kapena khungu ndipo samasokoneza kagayidwe kakang'ono ka glucose m'thupi. Amakhalanso ndi zovuta zochepa kuposa metformin, yomwe itaya mutu wa chinthu chabwino kwambiri komanso chogwiritsidwa ntchito kwambiri pothandizira matenda a shuga.

Koma izi zisanachitike, mbadwo watsopano wa mankhwala opatsirana odwala matenda ashuga ayenera kudutsa bwino magawo onse a kafukufuku ndikutsimikizira mosavomerezeka kugwira ntchito kwake ndi chitetezo.

Sayansi siyimayima, ndipo nayo mankhwala apamwamba ndi matekinoloje amapangidwa.

Dziwani zambiri za pulogalamu yatsopano yochepetsa thupi:

Mbadwo watsopano wa antidiabetesic othandizira amatha kusintha m'malo mwa metformin ndi analogues, omwe atha kukhala othandiza kwambiri pochiza matenda ashuga, koma kumbukirani kuti kudya mokwanira komanso kuchita masewera olimbitsa thupi ndi chinthu chofunikira komanso chofunikira kwambiri pakukhazikika kwa shuga.

1. 
   A John F. F. Lakecock Fundamentals of Endocrinology / a John F. Lakecock, a Peter G. Weiss. - M.: Mankhwala, 2016 .-- 516 p.
2. 
   Chithandizo cha endocrine matenda. M'mavoliyumu awiri. Gawo 2, Meridians - M., 2015 .-- 752 p.
3. 
   Matenda a Zefirova G.S. Addison / G.S. Zefirova. - M: Nyumba yosindikiza boma la mabuku azachipatala, 2017. - 240 c.

Ndiloleni ndidziwitse. Dzina langa ndi Elena. Ndakhala ndikugwira ntchito ya endocrinologist kwa zaka zoposa 10. Ndikukhulupirira kuti pakadali pano ndili katswiri pantchito yanga ndipo ndikufuna kuthandiza alendo onse omwe amapezeka patsamba lino kuti athetse zovuta koma osati ntchito. Zinthu zonse za tsambalo amazisonkhanitsa ndikuzikonza mosamala kuti athe kufotokoza zambiri zofunikira. Musanagwiritse ntchito zomwe zikufotokozedwa pa webusayiti, kukambirana ndi akatswiri ndizofunikira nthawi zonse.