Kuphatikiza kwa Metformin ndi Mowa

Metformin ndi mowa ndi adani okhalitsa komanso osakhazikika. Chowonadi ndi chakuti mankhwalawa amaphatikizidwa m'ndandanda wazomwe mankhwalawa sangaphatikizidwe ndi mowa mwanjira iliyonse.

Komanso, ngati mutenga Metmorphine limodzi ndi mowa, mutha kuyamwa poyizoni. Tsoka ilo, palibe aliyense amadziwa izi, bwanji nthawi zina amalemba maimidwe a odwala omwe amapatsidwa mankhwalawa akumwa mowa.

Kodi metformin ndi chiyani?

Pansi pa mankhwala Metformin mumvetsetse mankhwala omwe amagwiritsidwa ntchito pochiza matenda a shuga. Cholinga chake chachikulu ndikuchepetsa kudalira kwa insulin mwa wodwala, komanso kupewa kukula kwa kunenepa kwambiri.

Ngakhale kuti mutatenga Metformin kuchuluka kwa timadzi tating'onoting'ono timene timalowa m'magazi sikusintha, mankhwalawa amatha kusintha masinthidwe ake momwe amathandizira thupi la wodwalayo. Chifukwa chake, mwachitsanzo, ntchito yake yogwira ntchito imathandizira kuchepa kwa mafuta acids, chifukwa chomwe njira yosinthira glucose kukhala zinthu zina zofunika m'thupi imathandizira.

Zotsatira zake, kuchuluka kwa magazi a wodwalayo kumakhala bwino, ndipo kuchuluka kwa shuga m'magazi ake kumachepetsedwa. Ndikofunika kudziwa kuti mankhwalawa amatha kufikira kuchuluka kwa magazi a wodwalayo pokhapokha maola asanu ndi limodzi atatha kumwa. Komanso, kuphatikiza kwake kukuchepa.

Pali mankhwala angapo omwe amapangidwa motengera Metformin, pomwe onsewa ali m'gulu la Biguanides. Mwa mankhwala omwe ali mndandandandawu, mwachitsanzo, wina akhoza kutcha Fenformin, Buformin, ndi Metformin palokha. Sov remen6m awiri oyambirawa sagwiritsa ntchito, chifukwa zotsatira zawo zinali zoyipa za wodwalayo ndi lactic acid.

Ponena za Metformin, pali mayina angapo a mankhwalawa, mwachitsanzo, monga Giliformin kapena Fomu Pliva. Nthawi zambiri, odwala matenda a shuga amapatsidwa mankhwala monga Siofor. Chowonadi ndi chakuti chimasokoneza mkwiyo wamatumbo a wodwalayo ndipo ndi wotsika mtengo kuposa mitundu ina ya Metformin.

Ndikofunika kudziwa kuti mankhwalawa onse omwe ali ndi mankhwalawa ali ndi mawonekedwe ofanana, pomwe akusiyana wina ndi mzake pakungodziyeretsa mankhwala, komanso kapangidwe kazinthu zothandizira. Mulimonsemo, mankhwala onse omwe ali mgululi ayenera kumwedwa kokha ngati akuwuzidwa ndi adokotala. Kupanda kutero, kuchuluka kwa shuga m'magazi ake kumatha kutsika kwambiri, komwe kumayambitsa kupweteka komanso kufa kwa wodwalayo.

Ngati mumatsatira zomwe dokotala wakulemberani, komanso malangizo a mankhwalawo, nthawi zambiri pamakhala zotsatirapo zoyipa. Nthawi yomweyo, amakhala okhazikika pamalo a wodwalayo, zomwe zimapangitsa kuti chiwonetsero cha matenda a shuga chidziwike.

Zotsatira zake, chikhululukiro chokhazikika cha matenda oyambawa chitha kuchitika.

Pafupipafupi kayendetsedwe ndi zoyipa

Metformin, monga mankhwala aliwonse, ali ndi zovuta zake. Mwachitsanzo, mwachitsanzo, wodwalayo amatha kukumana ndi mavuto ambiri komanso kumva mseru. Nthawi zina, kutsegula m'mimba kumatha kupezeka, komanso zinthu zoipa monga kuchepa kwa magazi m'thupi komanso kuchepa kwa magazi. Zotsatira zoyipa kwambiri zitha kukhala mkaka acidosis, pomwe odwala ambiri amaganiza motere: "Ngati ndimamwa mowa pang'ono, ndiye kuti nditha kugwiritsa ntchito Metformin nthawi yomweyo." Izi siziri choncho, chifukwa ngakhale kumwa pang'ono kumatha kukulitsa kwambiri lactic acidosis.

Kutengedwa ndi wodwala matenda ashuga, Metformin nthawi zambiri imalowetsedwa m'magazi kudzera m'mimba. Popeza mphamvu zake zimatenga maola awiri kapena asanu ndi awiri, mankhwalawa amayenera kumwa katatu patsiku. Pomwe mungadumphe kumwa mankhwalawa, kutha kwake kumachepetsedwa kwambiri. Ichi ndichifukwa chake simungalole kukhazikitsidwa kwa mowa panthawi ya mankhwalawa.

Ngati timalankhula za zakumwa monga vodka, ndiye kuti mowa umalowa m'magazi pafupifupi nthawi yomweyo. Zotsatira zake, pakukhudzana ndi mankhwala omwe amafotokozeredwa ndi mowa, lactic acid imayamba, lactic acidosis imayamba. Tiyenera kudziwa kuti ziphunzitso zake, mowa umatha kutha pambuyo pa maola asanu ndi limodzi mpaka asanu ndi awiri atatha kumwa mankhwalawa. Komabe, zakumwa zoledzeretsa zimalepheretsa ntchito ya ma enzyme a chiwindi, ndipo izi, zimayambitsa glycimia.

Chifukwa chake, simungamwe mowa ndi Metformin, pokhapokha ngati wodwala yemwe ali ndi matenda ashuga ayenera kuvala kuti aletse mankhwalawo ndikusowa muyeso umodzi wa mankhwalawa. Komanso, nthawi zambiri, samaphonya kamodzi, koma awiri Mlingo wa mankhwalawa. Zotsatira zake, kugwiritsa ntchito bwino mankhwalawa kumatsika kwambiri ndipo wodwalayo amamva kuwonongeka mu thanzi lawo.

Mulimonsemo, mankhwala omwe afotokozedwawo ayenera kumwedwa moyang'aniridwa ndi dokotala. Chowonadi ndi chakuti chithandizo chilichonse munthawi yake chikuyenera kusinthidwa, kutengera zotsatira zomwe zakonzedwa.

Ngati mungadzipangire nokha, kuthandizira kwake kumakhala kopanda zero, ndipo nthawi zina kuvulala kwambiri kungachitike kwa wodwalayo.

Kodi lactic acidosis ndi chiani?

Popeza mankhwala omwe amafotokozedwawo ali ndi zovuta kupanga, munthawi yamankhwala amatha kukhazikika. Makamaka akamwetsa mowa.

Pankhaniyi, anthu ambiri omwe amamwa amakhala ndi poizoni chifukwa ali ndi vuto la metabolic. Chowonadi ndi chakuti munthu woledzera akamwetsa mankhwala osambitsidwa, osambitsidwa ndi mowa, thupi lake limatha kupanga kuchuluka kwa lactic acid.

Chifukwa chake, wodwala yemwe amamwa mowa wotsatira amalandila poyizoni, zomwe zingayambitse kuchepa kwa magazi, aimpso, mtima kapena chiwindi kulephera, mavuto am'mapapo. Zizindikiro za lactic acidosis ndi:

1. Kupezeka kwa nseru kwambiri, kuchuluka, kusanza.
2. Kufooka ndi kupanda chidwi.
3. Zowawa zakuthwa kumbuyo kwa sternum ndi m'misempha.
4. Maonekedwe akaphokoso komanso kupuma kwambiri.
5. Mutu wowopsa wa matenda ashuga.

Pazowopsa kwambiri, zotsatira za kutenga Metformin zimatha kuwoneka ngati zakomoka. Amamveka ngati dontho lakuthwa pakukakamiza, pomwe khungu limakhala lotuwa kwambiri, nkhope imaloza, ndipo manja ndi miyendo zimatha “kuwundana”. Zotsatira za poyizoni zimatha kuchitika kwambiri, mwachitsanzo, zingakhale kuphwanya kachitidwe ka ziwalo zamkati pamtima

Kupitilira apo, zinthu zitha kuyamba kukhala zovuta kwambiri pamene magazi m'thupi la wodwalayo azizirakulirakulira, zomwe zimakulitsa mkhalidwe wa wodwalayo. Pomaliza matendawa, hypoxia ya ubongo imayamba. Zotsatira zake, wodwalayo amakumananso ndi vuto loti amwalira msanga.

Ngati munthu waikidwa poizoni chifukwa chomwa mankhwalawa komanso mowa, amafunika kuyimbidwa mwachangu, komanso kulandira chithandizo chamankhwala ena.

Mwachilengedwe, ndibwino kuti musalole izi, chifukwa chake, choyamba, zidzakhala zofunikira kuphunzira malamulo otenga Metformin, omwe amati ndizosatheka kuigwiritsa ntchito wodwala asanamwe mowa.Nzika zomwe zimanyalanyaza lamuloli zimapwetekedwa ndi njira yofotokozedwayo, ndikupititsa patsogolo thanzi lawo.

Zoopsa ndizowopsa poyizoni pomwe wodwalayo adalakwitsanso mlingo wa mankhwalawo. Pankhaniyi, kufa kumatha kuchitika mu maola ochepa.

Chifukwa chake, odwala matenda ashuga omwe akalandira chithandizo choterechi amalangizidwa kusiya kumwa.

Choyamba thandizo poizoni

Mulimonsemo, wodwala aliyense yemwe ali ndi matenda ashuga komanso abale ake ayenera kudziwa zoyenera kuchita poyizoni. Chowonadi ndi chakuti zotsatira zake ndi zazikulu kwambiri, kotero chinthu choyamba chomwe chikufunika kuchitidwa ndikupereka nzika yovulalayo kuchipatala posachedwa. Momwemonso, pakumangidwa kwamapumidwe ndikukhazikika pang'onopang'ono pakuyenda magazi, ndikofunikira kuti musangoyitanitsa ambulansi, komanso muziyendetsa pang'onopang'ono pomwepo.

Ma ambulansi isanafike, mulimonse, zidzakhala zofunikira kupatsa ozunzidwayo mpweya wabwino. Chifukwa chake ngati ali poyizoni chifukwa chakumwa mankhwala ndi mowa waposachedwa, afunika kupereka mpweya wabwino watsopano.

Kuphatikiza apo, ngakhale adokotala asanafike kwa wodwalayo, ndikofunikira kuti azitsuka mwachangu zam'mimba kuti aletse kulowetsedwa kwa mowa ndi mankhwala m'magazi a wodwala. Pa chifukwa chomwechi, mutha kupatsa munthu wovulalayo kuti amwe pafupifupi malita asanu a madzi ofunda pa 38-40 ° C. Kudzakhala kofunikira kumusambitsa, popeza muzu wa lilime ndi pansi pa pharynx ayamba kukhumudwitsa. Kusanza kuyambika, mudzafunika muperekenso chakumwa china chofunda ndikubwereza njirayi kanayi kasanu ndi kamodzi.

Ponena za poizoni wa Metformin poyizoni, makamaka amatanthauza kutaya thupi kwa wodwalayo kuchokera ku ziphe ndi poizoni. Chifukwa chaichi, kukakamiza diuresis ndi munthawi yomweyo magazi ambiri amagwiritsidwa ntchito. Kuphatikiza apo, zotsatira zabwino komanso zopitilira zimaperekedwa ndi mankhwala othandizira, omwe amaphatikiza kuyambitsa kwa 20% shuga mkati mwa mtsempha wa wodwalayo kuti abwezeretse mulingo wake wabwinobwino m'magazi. Komanso muzochitika zotere, glycogen imayendetsedwa ndi intramuscularly.

Komanso, ngati pali chiopsezo cha chikomokere, njira yothetsera adrenaline imabayidwa mosavuta, ndipo atamwa mankhwala odana ndi matenda ashuga, amapereka njira yofutira ya sodium chloride, yomwe imayambitsa kusanza. Kenako, sodium sulfate imapatsidwa muyeso wa supuni imodzi pa lita imodzi yamadzi, yomwe imatsukidwa ndi tiyi wokoma kapena madzi. Mtsogolomo, wodwalayo akuwonetsedwa chithandizo chamankhwala.

Pa mankhwala a lactic acidosis omwe ali ndi matenda ashuga, amaletsedwa kumwa mowa. Kuphatikiza apo, wodwalayo adzafunika kutetezedwa kuti asayerekezedwe ndi dzuwa. Chakudya champhamvu chokhazikika chimapangidwanso.

Panthawi yomwe acidosis imatchulidwa pang'ono ndipo palibe chizindikiro chododometsa ndipo impso imagwira ntchito bwino, zidzakhala zofunikira kuchita mayeso a labotale ya alkalization ndi sodium bicarbonate.

Kanemayo munkhaniyi ayankhula za kuchepa kwa shuga kwa Metformin.

Lactic acidosis

Vutoli limakhala ndi zakupha, mwamwayi, ndizosowa kwambiri, koma ngati wodwalayo samamwa mowa. Kuphwanya izi zoletsa, chiopsezo cha lactic acidosis chimawonjezeka nthawi zina.

Zakumwa zoledzeretsa zimapangidwa mwanjira yapadera, zomwe zingayambitse kuchuluka kwa lactate ngakhale mwa munthu wathanzi kwathunthu. Kuchita koteroko ndikofunikira kuti mphamvu yopulumutsidwa igwiritsidwe ntchito pa metamorphosis ya ethanol kuti acetaldehyde.

Ntchitoyi imatsimikiziridwa ndi kuyesa: ngati Metformin ndi ethanol amagwiritsidwa ntchito panthawi imodzi 1 mg / kg, ndiye izi zidzapangitsa kuti 3act-lactate iwonjezeke.

Kuperewera kwa Vitamini

Chifukwa choyamba chomwe zinthu zakumwambazi zimakhalira ndikusowa kwa vit. B1.Ndizodziwika bwino kuti zakumwa zoledzeretsa zimasokoneza kuyamwa kwa vitaminiyu m'mimba, pomwe zakumwa zoledzeretsa sizimapezeka.

Wodwala akamamwa mowa, padzakhala:

• Mafuta a B1 m'matumbo am'mimba amawonongeka
• Kufunika kwa vitamini kumachulukira kwambiri
• Mkhalidwe wopanda thupi
• Chiwopsezo cha lactic acidosis chidzachuluka kwambiri.

Hypoxia ndi njala ya oxygen. Nthawi zambiri, kukula kwa acidosis ndi zotsatira za kuchepa kwa minofu ya oxygen. Potere, ngati mumamwa mowa, ndiye kuti hypoxia ya ubongo idzachitika. Zomwe zimayambitsa zili m'mitsempha yamagazi ndimagazi, kuchepa kwa oksijeni kumayambitsa chisangalalo, chomwe aliyense amakhala atamwa.

Kugundika kwa magazi kumatchedwa kuundana kwa magazi komwe kumapangidwa chifukwa chogwirizanitsa kuchuluka kwa maselo ofiira amwazi. Zomwe zimayambitsa zimachitika ndi zakumwa, zomwe zimalowa m'magazi athu tikamamwa vinyo wokwera mtengo komanso wotsika mtengo, vodika, cocktails, mowa, etc. Mowa wonse womwe uli ndi zakumwa zoledzeretsa zili ndi chinthu chachikulu - mowa wa ethyl.

Impso zolakwika

Chofunika kwambiri chobera chifukwa chomwe Metformin ndi mowa umaletsedwera ndi matenda a impso oyambitsidwa ndi uchidakwa.

Ngakhale kugwiritsa ntchito kamodzi kwa mankhwalawa ndi mowa mwa iwo omwe alibe matenda omwe akufotokozedwa kumatha kuchepetsa ziwalo, mwakutero zimapangitsa kuchepa kwa mankhwalawo. Izi, zidzatsogolera ku bongo wambiri ndikukula kwa zotsatira zowopsa.

Chowonadi ndi chakuti ethanol imapanga katundu wambiri pama enzymes a chiwindi, ndikupangitsa hypoglycemia. Zotsatira zophatikiza mankhwalawa ndi mowa zimatha kukhala chikomokere.

Imaphatikizidwa ndi swoon, yosavuta kusokoneza ndi mkhalidwe woledzera kwambiri. Anthu ozungulira, akufuna zabwino kwambiri, adzagonetsa oledzera, koma kwenikweni pakadali pano ndikofunikira kupereka chithandizo choyamba ndikuyembekezera kuti ambulansi ifike.

Zotsatira zake

Kutengera kwa Metformin ndi mowa kumatha kubweretsa lactic acidosis.

Zizindikiro zake ndi izi:

• Kutsitsa magazi
• Chisokonezo
• Zofooka zambiri
• Chisoni
• Kutaya kulumikizana ndi ena
• Nthawi zambiri amapuma.

Zotsatira zoyipa ndi hyperventilation, yomwe imatsatana ndi kuchepa kwa kuchuluka kwa kaboni dayokisi m'magazi.

Kuphatikiza kwake kochepa sikungakwanitse kupereka zokwanira ndi mpweya, chifukwa hemoglobin, ngakhale imamangilira mpweya wabwino, siyingathe kuifalitsa. Chifukwa chake, hypoxia imachitika.

Contraindication

Tisanaganizire kuchuluka kwa mankhwalawa monga Metformin ndi mowa, timaganizira zopinga zomwe zimagwiritsidwa ntchito pa mankhwalawa:

• matenda akulu a impso ndi chiwindi,

• matenda amtima ndi m'mapapo
• kufalikira kwa ziwalo zosadziwika bwino,
• Musagwiritse ntchito amayi oyembekezera, komanso mukamayamwitsa.
• ndizoletsedwa kugwiritsa ntchito mankhwalawa chifukwa cha uchidakwa wambiri,
• lactic acidosis.

Kodi mowa umagwira bwanji anthu omwe ali ndi matenda ashuga

Musanaganize momwe thupi la munthu limakhalira ndikuphatikiza mankhwalawa ndi mowa, muyenera kumvetsetsa momwe mowa wambiri umatikhudzira.

Chonde dziwani kuti mukamamwa mowa, kumasulidwa kwa glycogen m'chiwindi kumatsekedwa, ndipo kuchuluka kwa insulin kumawonjezeka kwambiri. Pankhaniyi, chiopsezo chotenga matenda monga hypoglycemia chimachulukirachulukira.

Koma izi sizili kutali ndi onse. Kumwa pafupipafupi zakumwa zoledzeretsa kumathandizira kuti ziwonongeko za maselo. Choopseza ndikuti shuga omwe amalowa m'thupi amalowa m'maselo, ndikudutsa membrane woteteza. Izi zikusonyeza kuti kuchuluka kwa shuga m'magazi kumachepetsedwa kwambiri. Chifukwa chake, munthu yemwe ali ndi matenda ashuga sangathe kukhutitsa thupi lake chifukwa chokhala ndi njala nthawi zonse.

Chifukwa chake, ngakhale mumamwa zakumwa zoledzeretsa, ndikulimbikitsidwa kwambiri kuti chakudya chamagulu azikhala m'gulu la chakudya. Pokhapokha mwa njira imeneyi ndi pomwe mwayi wakukula kwa hypoglycemia ungachepe. Malinga ndi akatswiri, odwala matenda ashuga ayenera kuyang'anitsitsa zakudya zawo ndikutsatira zakudya zomwe sizimaphatikizapo mowa.

Ngakhale magalamu makumi awiri ndi asanu a mowa wamphamvu amathandiza kuchepetsa shuga. Chifukwa chake, mukamamwa kwambiri, matendawo amakhalanso ovuta.

Metformin ndi mowa: kuyanjana ndikugwirizana, zotsatira, ndemanga

Mankhwala Metformin samangotenga matenda a shuga a mtundu wachiwiri, amagwiritsidwa ntchito kunenepa. M'malingaliro a ogula, kugwiritsa ntchito koteroko kumatanthauza kusintha mankhwalawo kukhala chakudya chowonjezera, ndikupangitsa Metformin kukhala yotetezeka, yovomerezeka yophatikizidwa ndi mowa. Koma kodi ndizotheka kumwa zakumwa zoledzeretsa ndikuchiritsa matenda ashuga, zimakhala ndi zotsatirapo zaumoyo?

Synthethet metformin imagwiritsidwa ntchito pochiza mtundu wa 2 wosagwirizana ndi insulin. Mankhwala ndi a gulu la hypoglycemic othandizira, ndi othandiza kwambiri, ochepa contraindication poyerekeza ndi ena othandizira odwala matenda ashuga.

Zotsatira za pharmacological

Mankhwalawa amathetsa kuyamwa kwa glucose m'matumbo, imathandizira kugwiritsidwa ntchito kwake mwa zotumphukira, zomwe zimapangitsa kuchepa kwa shuga m'magazi a shuga. Mankhwala samalimbikitsa kaphatikizidwe ka insulin, samathandizira pakuchepa kwa mphamvu ya maselo a pancreatic beta. Mankhwala amatulutsa cholesterol, lipids m'magazi, amachepetsa thupi.

Mukamwa pamimba yopanda kanthu, chithandizo chambiri chimatha pambuyo pa maola awiri, mutatha kudya - pambuyo pa maola 2,5. Imapukutidwa makamaka ndi impso. Hafu ya moyo wamwazi ndi maola 17.6.

Ndi kulephera kwa aimpso, theka la moyo limakulitsidwa, chiwonetsero cha impso chimachepetsa - kuchuluka kwa magazi (ml) omwe impso zimatha kuwulula pakamphindi.

Zambiri za lactic acidosis

Vutoli mu matenda a shuga limawerengedwa kuti ndi loopsa, lingathe kupha. Nthawi zambiri izi ndizosowa kwambiri. Nthawi zambiri, anthu omwe ali ndi vuto lomwa mowa mwauchidakwa amadziwitsidwa izi. Wodwala akalandira chithandizo ndi Metformin ndikumwa mowa nthawi yomweyo, pamakhala chiopsezo chachikulu cha lactic acidosis.

Mowa umagwira m'thupi la wodwalayo m'njira yoti umatha kuwonjezera kuchuluka kwa mkaka nthawi zina, izi zimachitika ngakhale mthupi la munthu wamba wathanzi.

Asayansi adachita maphunziro apadera, chifukwa chomwe zidatha kukhazikitsa kuti kuphatikiza monga Metformin ndi mowa kumakulitsa kuchuluka kwa lactate m'magazi kuyambira katatu mpaka khumi ndi atatu. Panthawi yoyeserera, mulingo woyenera wa mankhwalawo palokha komanso gramu imodzi ya mowa pa kilogalamu imodzi ya kulemera kwa munthu idatengedwa.

Mavitamini Aakulu

Chimodzi mwazomwe zimayambitsa lactic acidosis ndikusowa kwa mavitamini m'thupi. Izi makamaka za vitamini B1. "Metformin" ndi mowa, kuwunika kwa momwe mungawerengere m'nkhaniyi, mutagwiritsidwa ntchito limodzi, kumapangitsa kuti mavitaminiwa asowa. Vutoli limakula kwambiri mwa anthu omwe amangomwa mowa wambiri.

Zomwe zimachitika mthupi mutatha kumwa mowa

Kodi Metformin ingatengedwe ndi mowa? Funso ili limadetsa nkhawa anthu ambiri omwe akumwa mankhwalawa. Yankho lomaliza la madokotala ndi ayi, chifukwa njira zosayenerera ziyamba kuchitika mthupi, ndizo:

• Vitamini B1 idzalowa bwino m'matumbo, zomwe zikutanthauza kuti thupi lifunika magwero ena a chinthu ichi.
• Ngati mumamwa zakumwa zoledzeretsa zilizonse, thupi lambiri la vitamini B1 lidzawonedwa m'thupi,
• , ndipo, kuwonjezeka kangapo chiopsezo cha lactic acidosis.

Ganizirani ngati muli okonzeka kudzipereka.

Kugwiritsa ntchito nthawi yomweyo zinthu monga Metformin ndi mowa (kuyenderana, ndemanga zikufotokozedwa m'nkhaniyi), kumayambitsa kuperewera kwa mpweya waubongo. Zotsatira zake, matenda monga hypoxia amawoneka - kuperewera kwa oxygen kosakwanira m'maselo.

Vutoli limachitika chifukwa chotulutsa mitsempha yamagazi ndimagazi ang'onoang'ono. Ndi chifukwa cha izi kuti munthu akhoza kumva kusangalala kwina atamwa mowa. Izi sizongokhudza mowa wokhala ndi mowa wambiri, komanso za vinyo, mowa, cider ndi zina.

M'chakumwa chilichonse chomwe chimakhala ndi mowa pali ethyl, yomwe imapangitsa kuti magazi azituluka.

Zomwe zidzachitike ndi ma enzymes a chiwindi

Chonde dziwani kuti mowa ungalepheretse magwiridwe antchito a chiwindi. Ndipo izi, zidzatsogolera ku hypoglycemia. Ngati zigawo zikuluzikulu za mankhwalawo zili m'magazi, ndiye kuti zotsatirazi zimatha kukhala kuphwanya kwa magazi.

Dziwani kuti izi ndizosavuta kusokoneza ndi chidakwa wamba. Koma pankhaniyi, muyenera kuchitapo kanthu mwachangu komanso mwachangu. Imbani ambulansi ndipo onetsetsani kuti mwalankhula zakuphatikiza mowa ndi Metformin.

Ngati munthu sanafooke, ndiye kuti madokotala amalimbikitsa kuti amupatse tiyi wokoma kapena kupereka maswiti.

Metformin ndi mowa: kuchuluka kwake kungatengedwe

Mutamwa mowa, mutatha kumwa Metformin pasanathe masiku awiri pambuyo pake. Nthawi zambiri nthawi imeneyi imakhala yokwanira kubwezeretsa ntchito ya impso. Nthawi yomweyo, zindikirani kuti mowa samangotanthauza kumwa chabe, komanso mankhwala omwe amakhala ndi mowa.

Palibe chifukwa osatenga "Metformin" kale kuposa masiku angapo ngakhale mutamwa tincture kapena mowa wamadzimadzi wambiri.

Odwala achichepere amatha kumwa mowa pambuyo pa Metformin maola 18 mpaka makumi awiri pambuyo pake. Kwa okalamba, palibe nthawi yokhayo yomwe yakhazikitsidwa. Chonde dziwani kuti nthawi yothetsera mankhwalawa ndi odwala chiwindi kapena impso iwonjezeka kangapo.

Malinga ndi malangizo ogwiritsira ntchito, mankhwalawa amayenera kumwedwa kawiri pa katatu patsiku, kotero palibe njira yophatikiza ndi zakumwa zoledzeretsa.

Ndemanga za odwala ndi madokotala

Mwamwayi, madokotala salemba zambiri za lactic acidosis. Komabe, chizolowezi cha izi chikukula chaka chilichonse. Sizokayikitsa kuti ngakhale wodwala m'modzi yemwe wakumanapo ndi matendawa angafune kuphatikiza zakumwa zoledzeretsa ndi Metformin (kapena mankhwala ena ochepetsa shuga).

Ndikofunikira kuti odwala matenda ashuga aphunzire kuzindikira zizindikiro za matenda. Malinga ndi kuwunika kwa wodwala, izi zimadziwika ndi kufooka kwa minofu, kuiwala pafupipafupi, kupweteka mutu komanso kufooka thupi lonse. Ngati matendawa ayamba kukulira, ndiye kuti kupweteka mutu, kusanza ndi mseru kumawonjezeredwa ndi zizindikirozi. Pambuyo pake, munthu amatha kugwa. Milandu yomwe ikupita patsogolo kwambiri nthawi zambiri imapha.

Zachidziwikire, dokotala aliyense amatsimikizira mfundo yoti mowa ndi mankhwala ochepetsa shuga sangaphatikizidwe mulimonse. Komabe, si odwala onse omwe amamvera malangizo a madokotala. Ena mwa iwo amapuma pakati Mlingo wa zinthu izi. "Metformin" ndi mowa (kudzera mu zochuluka zomwe zingatengedwe, zomwe zafotokozedwa m'nkhaniyi) zitha kuphatikizidwa pokhapokha ngati pali kupuma kwakutali pakati pa kugwiritsa ntchito mankhwalawa. Koma kuchokera pakuwona chithandizo choyenera, kuchita izi ndikotsutsana kwathunthu. Khalani athanzi!

Zotsatira zoyipa

Zotsatira zambiri zoyipa kuchokera m'matumbo am'mimba.Zosintha izi zikuwonekera:

• kukomoka
• matenda am'mimba (m'mimba)
• nseru
• ulemu, kupweteka m'mimba komwe kumachoka ndi kudya,
• kulawa kwazitsulo mkamwa.

Kulandiridwa kwa Metformin kumatha kukulitsa mayamwidwe a folic acid, vitamini B12, zotsatira zoyipa za metabolism, zowonetsedwa ndi glycemia, lactic acidosis ndizotheka.

Mawonetseredwe ofanana amayenda ndi:

• kupweteka kwa minofu
• kugona
• kutsitsa magazi
• bradyarrhythmia - kuchepa kwa kugunda kwa mtima (osachepera 60 kumenyedwa pamphindi) ndi kusokonezeka poyimba kwa kugunda kwa mtima.

Metformin ndi mawonekedwe ake amapezeka mwanjira ya mapiritsi azomwe amachita pafupipafupi. Zofanizira za Metformin zimaphatikizapo: Glucofage ndi Glucofage yaitali, Bagomet, Glformin, Diaformin OD, Metfogamma, Metformin MV-Teva, Metformin Richter, Siofor, Formmetin.
Pa kanema wonena za Metformin:

Kudziwana ndi mankhwalawa

Metformin ili m'gulu la zinthu zingapo zopangidwa ndipo imagwiritsidwa ntchito mochizira matenda a shuga mellitus II degree (mawonekedwe osadalira a insulin). Mankhwalawa ndi a gulu la mankhwala a hypoglycemic ndipo amatchuka chifukwa chothandiza kwambiri. . Ndemanga pa mankhwalawa zimatsimikizira izi.

Zomwe zimachitika mu Metformin zimaphatikizapo kuyendetsa bwino kwambiri kutengera zovuta zotsutsana ndi zoyipa (poyerekeza ndi mankhwala ena antidiabetes).

Kuyambira kumasulidwa kwake (1957), Metformin wakhala mankhwala otsogola pakusamalira shuga, makamaka ndi kunenepa kwambiri. Choyimira pakukula kwa adipose minofu ndi insulin. Mphamvu ya mankhwalawa imatha kuchepetsa kwambiri, ndipo, chifukwa chake, imathandizira kuchepetsa thupi. Chifukwa cha izi, anthu ambiri onenepa kwambiri amagwiritsa ntchito mankhwalawa pofuna kuchepetsa thupi.

Pharmacology ya mankhwala

Kuchita kwa Metformin kumadalira pakuimitsa njira yopopera shuga m'matumbo ndikufulumizitsa kuwonongeka kwake mu minofu ya zotumphukira. Zotsatira zake, mu plasma chizindikiro ichi chimatsika. Komanso, mankhwalawa samathandizira pakupanga insulin ndipo samapangitsa kuti achepetse kuchepa kwa maselo a pancreatic beta. Mankhwalawa amagwira ntchito motere:

1. Amachepetsa cholesterol.
2. Chimalimbikitsa kugwa kwa lipids.
3. Imakhazikika kulemera kwa thupi (ndi kuchuluka kwake).

Mapiritsi a mankhwalawa amatengedwa pamimba yopanda kanthu. Mutatha kumwa mapiritsi, muyezo wazakumwa zambiri zimawonedwa m'thupi pambuyo pa maola 1.5-2 (ngati piritsi linatengedwa mutatha kudya, pambuyo pa maola 2 mpaka 2-3). Hafu ya moyo wa zotsalira za mankhwala metabolites ndi pafupifupi maola 16 mpaka 17. Tiyenera kukumbukira kuti theka la moyo wa zotsalira za mankhwala lingachuluke pamaso pa kulephera kwa impso.

Kulembera

Ntchito yayikulu ya Metformin ndikuthandizira pochiza matenda a shuga mellitus II degree (osavulala a carbohydrate metabolism). Chida ichi chimagwiritsidwa ntchito makamaka kwa odwala omwe ali ndi kunenepa kwambiri (motsutsana ndi matenda oyambitsidwa), pomwe chithandizo chamankhwala sichisonyeza zabwino. Mtundu wa shuga wa I, Metformin amagwiritsidwa ntchito ngati cholumikizira chithandizo cha insulin choyambirira.

Kafukufuku waposachedwa atsimikizira kupambana kwa kugwiritsidwa ntchito kwa Metformin pothandizidwa ndi khansa zomwe zidayamba chifukwa cha matenda ashuga.

Metformin ndi yotchuka pakati pa anthu omwe amalota kuchepa thupi (ndipo si odwala matenda ashuga). Madokotala salimbikitsa kugwiritsa ntchito chida ichi ngati mtundu wowotcha mafuta, ngakhale chida ichi chimathandiziradi kuchepetsa thupi, chifukwa cha zinthu monga:

• kuthetsa mavuto
• kuchepa kwa chakudya chamafuta,
• mathamangitsidwe a makulidwe amakulu a adipose minofu,
• kuchuluka mayamwidwe glucose minofu minofu.

Koma pankhaniyi, ziyenera kukumbukiridwa kuti Metformin samawotcha mafuta amthupi, koma zimangoyambitsa kuwonongeka kwamafuta. Ndiye kuti, zolimbitsa thupi zolimbitsa thupi ndizofunikira. Kuphatikiza apo, sizinakhazikitsidwebe momwe mankhwalawo amathandizira munthu wathanzi, chifukwa chake sikoyenera kugwiritsa ntchito kwa anthu omwe akudwala matenda a shuga.

Mukuyenera kudziwa kuti malinga ndi chithandizo cha Metformin, muyenera kutsatira zakudya zina, zomwe zotsatirazi siziphatikizidwa ndi zakudya:

• mowa
• maswiti
• mbatata
• pasitala.

Zotsatira zoyipa

Ngakhale kutetezedwa kwake, Metformin imatha kubweretsa zovuta zina. Kwambiri, mavuto oterewa amachitika kuchokera m'mimba . Amawoneka motere:

• kutsegula m'mimba kwa nthawi yayitali
• chisangalalo ndi kuphuka,
• kupweteka m'mimba,
• kulawa kwazitsulo
• nseru, zomwe zimayambitsa kusanza kwambiri.
• kuchepa kwathunthu kwa chikhumbo ndi chitukuko pamaziko a anorexia awa.

Kugwiritsidwa ntchito kwa Metformin kumatha kuyambitsa zovuta komanso malabsorption a vitamini B12 ndi folic acid. Zotsatira zowopsa, koma zowopsa, madokotala amaphatikizapo matenda a metabolic, omwe amaphatikizidwa ndi lactic acidosis ndi glycemia. Izi zimachitika motere:

• dontho lakuthwa magazi.
• kugona tulo masana
• kupweteka kwa minofu ndi minyewa
• bradyarrhythmia (kutsitsa kwamkati ndi kusokoneza munthawi yomweyo kugunda kwa mtima).

Mitu ya mankhwalawa

Pankhani ya zovuta zoyipa, adokotala amatha kusintha Metformin ndi mankhwala ena omwe ali ndi vuto lofananalo. Zofananira zotchuka za mankhwala ophatikizira mankhwala ophatikizidwa ndi mankhwala monga:

• Siofor
• Bagomet,
• Fomu,
• Chikwanje,
• Glyformin
• Metfogamma,
• Diaformin OD,
• Glucophage Long,
• Metformin Richter,
• Metformin MV-Teva.

Kukula kwa lactic acidosis

Metformin yokhala ndi zakumwa zoledzeretsa imakhala ndi zotsatirapo zoopsa, mowa nthawi zambiri umagawidwa mu shuga, makamaka mankhwala. Lactic acidosis ndi vuto lomwe lingayambitse wodwala matenda ashuga, limayamba kamodzikamodzi akamamwa mapiritsi, koma kumwa kwambiri kumawonjezera mwayi wa matenda.

Zinapezeka kuti kuphatikiza kwa mowa ndi Metformin pa mlingo wa 1 g / kg ya kulemera kwa thupi kumakwiyitsa kuchuluka kwa lactate (lactic acid) mwa nthawi 3-12.

Zizindikiro zoyambirira zokhala zoopsa ndi izi:

• kupumira msanga
• wopanda chidwi
• kusowa tulo usiku ndi kugona tulo masana.

Ndi kukula kwa matendawa, wodwalayo amawonetsa kusanza, kupweteka kwam'mimba komanso kuwonongeka msanga. Pamene matenda akuchulukirachulukira, kusokonezeka kwa chikumbumtima ndi minyewa kumakula.

Kuperewera kwa Vitamini

Chimodzi mwazinthu zoyipa zakukula kwa lactic acidosis ndikusowa kwama mavitamini a B mthupi . Mowa umakhala chifukwa cha izi ndipo umapangitsa maonekedwe monga:

• kuwonongeka mu mayamwidwe a vitamini B1 m'mimba
• Potengera maziko awa, kusowa kwa zinthu izi kumayamba,
• kuperewera kwa vitamini B-gulu kumabweretsa kukula kwa lactic acidosis.

Mkhalidwe wina womwe umakulitsa mwayi wa lactic acidosis. Hypoxia, motsutsana ndi kumbuyo komwe kuperewera kwa oxygen m'misempha ya thupi, kumawonjezera kuwoneka kwa matenda opha kangapo. Ndipo ndi ethanol yomwe imatsogolera ku hypoxia. Kumbukirani momwe mumasangalalira mutamwa kumwa - ndipo pambuyo pake, choyambitsa kupumulirako komanso chosangalatsa ndichosokoneza bongo. Matendawa amapezeka chifukwa chatsekeka mitsempha yamagazi ndimisempha - izi zimadziwika ndi gawo loyamba la kuledzera.

Kuwaza magazi ndi timagulu ting'onoting'ono ta magazi timene timapangidwa ndi gluing maselo ofiira amwazi. Cholinga chakudziphatika kwawo ndi mowa wa ethyl, womwe umachita mwanjira iyi pamagazi.

Matenda a impso ndi chiwindi

Kutsutsana kwathunthu potenga Metformin ndi uchidakwa. Ndipo munthawi imeneyi, mavuto akachitidwe ka chiwindi ndi impso nthawi zambiri amawonedwa. Mukaphatikiza chithandizo ndi mowa mwa wodwala, Metformin metabolites imachedwa, zomwe zimapangitsa kuti pakhale zovuta zina chifukwa cha bongo.

Kutengera izi, ntchito ya chiwindi ndi impso imavutika. Ethanol imalepheretsanso kugwira ntchito kwa ma enzymes a chiwindi, omwe pamaso pa matenda a shuga amapangitsa kukula kwa hypoglycemia.

Hypoglycemia ndi pathological syndrome, mkhalidwe wowopsa womwe umachitika ndi kuchepa kwamphamvu kwa glucose wamagazi.

Zotsatira zake, mowa ndi Metformin amatha kubweretsa wodwala kuti awoneke ngati kukomoka kwa hypoglycemic. Izi zimapangitsa munthu kusiya kuzindikira (ambiri amasokoneza munthu yemwe ali ndi chidakwa chachikulu). Ndipo nthawi zambiri, womwako amatsala yekha kuti "agone", pomwe akufunika thandizo kuchokera kwa madokotala. Ndi kukula kwa matendawa, gulu la ambulansi liyenera kutchedwa yomweyo. Madokotala asanafike, wovulalayo ayenera kumwa tiyi wokometsedwa ndi maswiti.

Zotsatira zoyenera kuziyembekezera

Poyerekeza zakumbuyo komwe kumamwa mowa nthawi yomweyo ndi Metformin (komanso mankhwala ofananawo), zizindikiro zotsatirazi ziyenera kuyembekezeredwa kwa wozunzidwayo:

• kufooka wamba
• chisokonezo,
• kupuma kosakhazikika
• Hyperventilation syndrome
• dontho lakuthwa magazi.
• kunyalanyaza, kusowa kachitidwe, kukondwerera.

Chodabwitsa cha hyperventilation ndi chiwonetsero chowopsa. Matendawa amapezeka motsutsana ndi maziko a kuchepa kwakukulu kwa mpweya m'magazi. Kuperewera kwa kaboni dayokisaidi kumayambitsa kuperewera kwa okisijeni ku minofu, zomwe zimapangitsa kuti pakhale hypoxia yayikulu.

Metformin ndi mowa: kumwa zochuluka motani

Mukamwa mowa, mutha kuyamba kulandira mankhwalawa pokhapokha ngati mukudwala kwambiri. Izi zimatheka pang'onopang'ono patatha masiku awiri ndi atatu kuyambira nthawi yomwe mumamwa. Mwa njira, sitiyenera kuiwala kuti mowa samangokhala zakumwa zoledzeretsa zokha, komanso mankhwala ena (makamaka osokoneza bongo) oledzera.

Ndi zoletsedwa kuyamba kulandira chithandizo ndi Metformin kale kuposa masiku awiri atamwa mowa kapena madzi / tincture wokhala ndi mowa.

Ponena za mwayi wakumwa atatha kuthandizira kochiritsira, pano mayankho amatengera zaka za wodwalayo:

• Achinyamata komanso athanzi ayenera kudikirira pafupifupi maola 18 mpaka 20,
• tsiku lenileni silinakhazikitsidwe kwa anthu okalamba, pankhaniyi muyenera kufunsa dokotala (izi zikugwiranso ntchito kwa anthu omwe akudwala matenda a chiwindi ndi impso).

Pa mankhwalawa pakokha, kupuma pakumwa sikulimbikitsidwa. Kumbukirani kuti mankhwalawa amatengedwa katatu tsiku lililonse kudzera munthawi yonse yomwe akupatsidwa. Chifukwa chake, ngati pali chikondwerero china chakumwa chakumwa chaukali, moyenera, mowa uyenera kusinthidwa ndi timadziti kapena zakumwa zamtundu uliwonse. Kupanda kutero, muyenera kusokoneza chithandizo, chomwe sichili njira yabwino yothandizira kukhudzika kwake.

Metformin yokhala ndi mowa wa matenda ashuga

Matenda a shuga amayamba chifukwa cha kufalikira kwathunthu kapena pang'ono mwa insulin m'magazi. Timadzi timeneti timayendetsa glucose komanso mgwirizano wake ndi maselo a ziwalo zamkati. Glucose ndi gwero lofunikira kwambiri lamphamvu kwa ziwalo zambiri. Mwachitsanzo, ubongo umapangidwa ndi mphamvu ya shuga. Tiziwalo zambiri komanso ziwalo zimatha kuzisintha pokhapokha mothandizidwa ndi insulin - izi zimadalira insulini. Ena amapirira popanda iyo - insulini -yokha. Ndi vuto la insulin, mtundu 1 wa shuga umayamba. Mtundu 2 umachitika pamene insulini siliyanjana ndi maselo amthupi. M'zochitika zonse zoyambirira ndi zachiwiri, mkhalidwewo ndiwopseza moyo, chifukwa shuga umangodziunjikira, ndipo ziwalo sizilandira mphamvu yayikulu.Mothandizidwa ndi Metformin, a 1 ndi 2 matenda a shuga amathandizidwa, chachiwiri, Metformin Richter nthawi zambiri amatchulidwa.

Magawo omwe amagwira ntchito a mankhwalawa amalimbikitsa njira ya glycolysis (kutsekeka kwa shuga ndi kutulutsidwa kwa mphamvu), kukonza magwiridwe a insulin ndi maselo. Tengani Metformin popanda mankhwala a dotolo ndiwotsutsana, chifukwa mankhwalawa ali ndi zotsutsana zambiri.

Kumwa mowa ndi matenda ashuga okha kungakhale koopsa. Mizimu yambiri imakhala ndi chakudya chamagulu, chomwe chimakulitsa shuga. Ndipo izi ziyenera kupewedwa kwambiri. Mutha kunena nthawi yomweyo kuti kumwa, odwala matenda ashuga, sikuletsedwa kwathunthu, chinthu chachikulu ndikusankha zakumwa zoyenera. Chifukwa chake, muyenera kusiya vinyo wokoma, ma cocktails, mowa wamdima. Zakumwa zatsopano zilizonse ziyenera kuyesedwa ndi glucometer. Vinyo wowuma amakhala ndi mafuta ochepa, motero si owopsa. Zomwezi zimagwiranso ntchito kwa mizimu yomwe ili ndi mphamvu 380 ndi pamwamba.

Izi ndizachidziwikire, za magawidwe oyenera a mowa. Kuphika muvinyo wowuma kapena makamaka vodika sikulimbikitsidwa ngakhale kwa anthu athanzi. Ngati atamwa mowa, odwala matenda ashuga amatha kukhala ndi hypoglycemia (kusowa kwa shuga m'magazi). Mowa wa Ethyl umalepheretsa kupezeka kwa shuga ndi chiwindi, izi pazokha sizowopsa, zotsatila zake zitha kukhala zoipitsitsa. Monga lamulo, shuga amabwezeretsedwa akangodwala shuga. Komabe, izi zimakwiyitsa kulumikizana kwakukukulu ndikuwopseza kuchuluka kwa shuga komweko. Chiwopsezo chachikulu chagona mu zizindikiro za hypoglycemia, chifukwa zovuta zaledzera zimafanana nawo. Pankhaniyi, nthawi zambiri munthu amakumana ndi:

• kulumikizana bwino ndi mawu,
• chizungulire
• kusanza ndi kusanza
• kuthamanga kwa magazi pankhope.

Chifukwa chofanana ndi zizindikiro, wodwalayo samalandira thandizo lofunikira, lomwe limakulitsa matenda omwewo. Glucometers, mwa njira, adapangidwa mu 1970 ndendende kuti athe kusiyanitsa pakati pa odwala omwe ali ndi shuga ochepa komanso zidakwa wamba.

Metformin ndi mowa zimapangidwa kuti zigwiritsidwe ntchito nthawi imodzi. Mankhwala sakudziwa bwino momwe amagwirizanira komanso momwe amagwirira ntchito mogwirizana. Komabe, zowona zimatsimikizira kuti odwala kuphatikiza mankhwalawa komanso kumwa pafupipafupi, chiopsezo cha mkaka acidosis chimawonjezeka. M'matenda akulu, matendawa amabweretsa kukomoka, ndipo zotsatira zakupha zidanenedwanso. Ngati magazi a wodwalayo atsika kwambiri, khungu limasinthasintha, nkhope zimakuthwa - muyenera kufunsa dokotala posachedwa.

Kuchuluka kwa zomwe mungamwe zimatengera nthawi yomwe mankhwalawo amamwa. Metformin iyenera kuchotsedwa kwathunthu kuchokera mthupi, njirayi imatenga pafupifupi maola 7. Ngati mowa wamwa, mapiritsi sayenera kumwa kwa maola ena 12. Wodwala ayenera kudziwa kuti kudumpha mankhwala kungakulitse matendawa. Koma pankhaniyi, ndibwino kuti tisapange ngozi yosakanikirana ndi mankhwala. Zotsatira zake zimakhala zowonekera komanso zovuta kwambiri.

Kuchokera pamiyeso yaying'ono ya mowa ndi mankhwala omwe amwedwa, kukulira kwa thanzi sikumawonedwa. Kungomwa kamodzi kwa mowa wochepa thupi (osapitirira 20 ml ya Mowa) sikungakhale ndi zotsatirapo zoopsa. Ndikofunika kukumbukira mukamamwa Metformin kuti muyenera kusamala kwambiri ndi kuchuluka kwa mowa ndi mtundu wake.

Metformin yochepetsa thupi: kuphatikiza mowa

Kuphatikiza pa kugwiritsidwa ntchito mwachindunji, Metformin imagwiritsidwa ntchito pakuchepetsa thupi. Imalimbikitsa kukhathamiritsa kwa mafuta acids, kumachepetsa chilimbikitso ndi mayamwidwe am'madzi. Komabe, kuwunika kwa omwe akuchepetsa thupi kukuwonetsa kuti zotsatira za kuwongolera kotereku zingakhale zosiyana. Nthawi zambiri, omwe akufuna kumanga mwachangu amakhala ndi mankhwala osokoneza bongo kapena amangogwiritsa ntchito molakwika.

Kugwiritsa ntchito mankhwala osavomerezeka ndi dokotala ndi koopsa kwambiri. Pali njira zambiri zochepetsera kunenepa popanda kuyika zotsatira zoyipa. Mwa awa:

• kupweteka m'mimba
• kugaya chakudya
• kusanza ndi kusanza
• chizungulire komanso kusazindikira.
• acidosis (m'malo ovuta kwambiri).

Kwa munthu wathanzi, ndibwino kufunsa katswiri wazakudya musanagwiritse ntchito mankhwalawa ndikupeza ngati angatenge.

Mwa anthu onenepa kwambiri chifukwa cha matenda ashuga, mankhwalawa amachepetsa shuga. Mwa munthu wathanzi, chizindikiro ichi sichimasintha mwanjira iliyonse. Palibe chifukwa choti Metformin igwiritsidwe ntchito ndi anthu omwe ali ndi:

• matenda opatsirana
• kulephera kwa chiwindi
• tsankho pamagawo a mankhwala,
• mtima wosagwira.

Komanso, iyenera kupewedwa pa mkaka wa m'mawere ndi pakati.

Mankhwala palokha sangatenthe mafuta. Chida ichi chimadziwika ndi othamanga komanso omanga thupi, chifukwa chimawathandiza kugwiritsa ntchito mphamvu kuchokera kumagulu amafuta, osati kuchokera ku minofu minofu. Chifukwa chake, Metformin imangothandizira kuchepetsa kunenepa. Kwa iwo omwe samavutikira ndi zolimbitsa thupi, mankhwalawa sangathandize. Mndandanda wazolowera masewera ukhoza kuphatikiza ogwiritsa ntchito zolimbitsa thupi, chifukwa momwe kugwiritsidwira ntchito kudzakhala koyenera.

Chachikulu pa "zakudya za metformin" zonse zimakhutira ndi omwe amakhulupirira kuti kumwa mankhwalawo ndikokwanira kuti muchepetse kunenepa. Kuchepetsa thupi kumachitika makamaka chifukwa cha zinthu zoyenera komanso masewera olimbitsa thupi. Ngati mupitiliza kudya zakudya zama calorie ambiri mukamamwa Metformin, palibe zotsatira zomwe zingakambidwe. Koma kusala kudya mwachangu kumatsutsana. Malangizo a mankhwalawa akuwonetsa kuti kudya kalori tsiku lililonse kuyenera kukhala osachepera 1000 kcal.

Pazakudya zoonda zomwe zimakhala ndi shuga sizimachotsedwa mu zakudya. Pansi pa chiletso: mphesa, nthochi, beets, kaloti, ndi zina zotero. Kuphatikiza apo, muyenera kusiya mbatata, mankhwala a ufa, oatmeal ndi mpunga wopukutidwa woyera.

Mapiritsi amatengedwa musanadye, 500 mg katatu patsiku. Pulogalamuyi sitha kupitirira masiku 20. Pambuyo pake, pumulani kwa miyezi iwiri. Kuphatikiza kwa zakudya ndi mowa, kumene sikulimbikitsidwa.

Mowa siwothandiza kwambiri pomenyera chithunzi chabwino. Kamodzi m'thupi, mowa wa ethyl umawoneka ngati wofunikira kwambiri. Thupi limazindikira kuti ndiwopseza ndipo limayesayesa kulichotsa mwachangu. Pomwepo, "kudya" chakudya, m'malo mopsinjika ndi mphamvu, chimayikidwa pambuyo pake, m'matumba a adipose. Ndiye kuti, kumwa mowa kumathandizira kuti pakhale kuchuluka kwa zakudya ndipo zakudya zonse ndizopanda tanthauzo.

Kuphatikizidwa kwa Metformin ndi zakumwa zoledzeretsa kumakhumudwitsidwa kwambiri ngakhale ndi anthu athanzi. Monga tawonetsera kale, kuyanjana kwa zinthuzi sikunaphunziridwe kwathunthu, motero zotsatira zake sizingachitike. Malangizo a mankhwalawa akuwonetsa kuti kumwa mankhwalawa pambuyo poyamwa poizoni kumatsutsana kwambiri. Ndiye kuti, ngati tsiku laphwando lili ndi mowa wambiri, ndikofunikira kudikira mpaka kuchotsedwa kwathunthu kwa Mowa m'thupi. Kwa akazi - masiku awiri. Kwa amuna - masiku atatu. Pambuyo pa kuchepa kwa thupi kumatha kutha, mutha kumamwa pakatha masiku osachepera 3-5.

Mapeto: ndizotheka kuphatikiza Metformin ndi mowa

Kugwirizana kwa mankhwalawa ndi mowa womwe umaganiziridwa sikumadziwika. Komabe, madokotala salimbikitsa kusakaniza zinthu izi. Kwa odwala omwe ali ndi giredi 1 ndi 2 matenda a shuga, kumwa zakumwa nthawi zambiri kumapha. Ndipo, akaphatikizidwa ndi mankhwala mwa odwala otere, chiopsezo cha lactic acidosis chimawonjezeka. Kwa odwala matenda ashuga, ndikofunikira kudziwa kuchuluka kwa zakumwa zoledzeretsa komanso kumwa zakumwa zosapatsa shuga zilizonse, pomwe kumwa mankhwalawa kumakhala kosavomerezeka kwa pafupifupi maola 12.

Omwe omwe akungoyesa kuchepetsa thupi sayeneranso kuyeseza thupi lawo, kuphatikiza Metformin ndi mowa.Zotsatira za izi zitha kungokhala osasangalatsa kapena kukula kwa matenda omwe kale sanali nawo. Potsirizira pake, kuchepetsa thupi kuyenera kuthana ndi vuto lalikulu kwambiri kuposa kukonza manambala. Pankhani yakugwiritsa ntchito milingo yaying'ono ya mowa, mapiritsi amatulutsidwa.

Chifukwa chake, simuyenera kumwa mowa ndi mankhwala (ambiri) kuti mukhale ndi thanzi. Pambuyo pa "ufulu" wachiwawa komanso kuledzera kwambiri, Metformin sangatengedwe kwa tsiku lina kapena awiri. Mutatha kumwa mankhwalawa, mutha kumwa pambuyo pa maola 7. Mowa, ndikofunikira kudziwa muyeso, ndiye kuti zotsatirapo zosasangalatsa zidzadutsa.

Ndingaphatikizire pati

Ngati, komabe, posakhalitsa muli ndi mtundu wina wa chochitika chomwe sichingagawidwe, ndiye ndikofunikira kudziwa kuti mutamwa Metformin nthawi yayitali bwanji.

Mwa malamulo onse, maola 48 ayenera kudutsa pakati pa kumwa mowa. Izi ndizomwe zimafunikira kuti ubwezeretse impso.

Mowa si zakumwa zokha, cocktails, cognacs, vin, etc., komanso mankhwala aliwonse omwe ali ndi mowa!

Chifukwa chake, ngati masiku osakwana 2 adadutsa kale kuchokera kuti kulowetsedwa ndi ethyl mowa, ndiye kuti Metformin ndi yoletsedwa.

Mu chamoyo chaching'ono, nthawi ino amatha kuchepetsedwa mpaka maola 18. Kwa okalamba, T1 / 2 sichinakhazikitsidwebe. Izi zikutanthauza kuti kuchoka kwa mankhwalawo ndikovuta, kumakhalabe m'thupi motalikirana, motero, ndizothekanso kugwiritsa ntchito mankhwalawo mukufunsidwa.

Kutengera kuti Metformin akuwonetsedwa kuti azilandira masiku onse atatu, ndizosatheka kusangalala ndi zakumwa zoledzeretsa panthawi yonse ya mankhwalawa ngati simukusokoneza mankhwalawo.

Malingaliro a akatswiri onse ndi ofanana - kugwiritsa ntchito Metformin pakumwa anthu ndizoletsedwa!

Osatengera chidwi ndi iwo omwe adamwa mankhwalawo. Chowonadi ndi chakuti ambiri a iwo amamwa mankhwala kuti athetse mapaundi owonjezera. Ndiwachichepere, ali ndi impso wathanzi, zakudya zoyenera ndi ziwiya zolimba. Mwina anali ochita bwino, ndipo sanamve zowononga zakuphatikiza.

Metformin ndi mankhwala omwe amathandizira kuwongolera zizindikiro za matenda amtundu wa 2 komanso. Madokotala samalimbikitsa kuti muzimwa mowa mukamamwa metformin. Zotsatira zake zoyipa zitha kukhala zowopsa m'moyo mukamamwa kwambiri mowa. Metformin ndi mowa zonse zimakhudza chiwindi komanso zimawonjezera zovuta za chiwindi.

Kodi metformin ndi mowa zimakhudza bwanji thupi?

Metformin ndi mankhwala otchuka, othandiza, komanso otchipa pochiza matenda a shuga a mtundu wachiwiri. Amagwiritsidwanso ntchito ngati prediabetes. Kugwiritsa ntchito metformin mwa anthu onenepa kwambiri omwe ali ndi matenda amtundu wa 1 kungathandizenso kuchepetsa kufunika kwa insulini ndikuwonjezera kuyang'anira kwa metabolic. Mankhwalawa amathandizira chidwi cha insulin, kulimbikitsa kuyamwa kwa glucose mu minofu ndikuchepetsa shuga m'magazi. Metformin imachepetsa kuchuluka kwa shuga komwe chiwindi chimapanga.

Mowa umakhudzanso shuga wa magazi. Koma chiwindi chikakakamizidwa kukhetsa mowa wambiri, umachepetsa shuga. Kuledzera kwa nthawi yayitali kumapangitsa kuti maselo azigwira insulin. Izi zikutanthauza kuti shuga wocheperako amatengedwa kuchokera m'magazi ndipo mulingo wake m'mitsempha umachuluka.

Mowa utamwa, kuwonongeka kwa chiwindi kumayambitsidwa ndipo kuthekera kwa chiwindi kupanga ndikupanga glucose kumachepetsedwa. Mikhalidwe monga chiwindi cirrhosis imatha kumakhazikika pakumwa zakumwa zoledzeretsa, zomwe zimachepetsa thanzi la chiwindi komanso kutsitsa shuga m'magazi.

Zakumwa zambiri zakumwa zoledzeretsa zili ndi shuga ambiri ndipo zimapangitsa munthu kukhala wonenepa kwambiri. Zakumwa zambiri zoledzeretsa zimakhalanso ndi kaboni, zomwe zimakweza shuga m'magazi ngakhale mwachangu kwambiri.

Matenda am'mimba ndizovuta zina zoyipa za metformin. Akuyerekezeredwa kuti munthu m'modzi mwa khumi omwe amamwa metformin adzakumana ndi zizindikiro.

Zotsatira zoyipa za metformin ndizofanana ndi zomwe zimayambitsa mowa, chifukwa chake, chikaphatikizidwa, zizindikiro zimatha kukula. Zotsatira zoyipa za metformin zimatengera kuchuluka kwa mowa womwe umamwa komanso pazinthu zina zaumoyo.

Zotsatira zoyipa za metformin ndi mowa

Zotsatira zoyipa za metformin zomwe zimakulitsidwa ndi kumwa mowa ndizophatikiza:

Ululu m'mimba kapena pamimba

Kudzimbidwa kapena kutentha kwa mtima.

Zizindikiro zambiri zimatha kutsitsidwa ndikumwa mankhwala ndi chakudya. Kumwa zamadzi zambiri kumathandizanso kuchepetsa zizindikilo. Thupi likangogwirizana ndi mankhwalawa, mavuto ambiri amachoka.

Ngakhale chiwopsezo chilichonse chimasiyana komanso zimadalira thanzi, anthu omwe ali ndi matenda osokoneza bongo omwe amamwa mowa komanso metformin amatha kukumana ndi mavuto osokoneza moyo.

Lactic acidosis

Mphamvu imapangidwa makamaka mu minofu, pomwe njira zotsata mpweya zimagwiritsidwa ntchito. Pogwira ntchito kwambiri komanso nthawi yayitali, kuchepa kwa okosijeni kumatha kuwonjezeka. Izi zimapangitsa kuti maselo ayambe kugwiritsa ntchito njira za anaerobic kapena mpweya wokhala ndi mpweya.

Kuphulika kwa shuga kwa anaerobic kumapangitsa kuti pakhale mapangidwe a lactic acid, omwe amakankhidwanso mpaka mkaka wa lactate. Lactate imasweka kukhala shuga m'magazi. Mitsempha ya m'magazi itha kukula mokwanira komanso kuchita masewera olimbitsa thupi kwa nthawi yayitali, chifukwa mpweya umafunika kuti uziyeretsa. Ngati lactate sichichotsedwa m'magazi mwachangu mokwanira, imatha kudziunjikira, ndikuwonjezera acidity yamagazi ndi minofu. Minyewa ya lactate ikakhala yambiri, lactic acidosis imachitika.

Metformin imachepetsa mayamwidwe a chiwindi ndi chiwindi, monganso mowa. Chiwopsezo chotenga mkaka acidosis mukamamwa metformin ndizosowa kwenikweni ndipo pafupifupi 0.0001%. Mukamamwa mankhwalawo ndi mowa, chiwopsezo chake chimakulanso.

Zizindikiro za lactic acidosis ikhoza kukhala yaying'ono, monga kupweteka m'matumbo ndi kugona. Amatha kukhala olakwika pazowoneka ngati amamwa mowa.

Milandu yayikulu imakhala ndi zizindikiro zowopsa zomwe zimawonekera msanga ndipo zimatha kukhala pachiwopsezo cha moyo.

Zizindikiro za Lactic Acidosis

Zizindikiro za lactic acidosis zimaphatikizapo:

Matumbo kapena zowawa, makamaka m'matumbo,

Kupumira msanga kapena kosaya

Kuthamanga kwa magazi

Kuthamanga kwa mtima

Hypoglycemia

Metformin imatha kuyambitsa hypoglycemia kapena kutsika shuga wamagazi akamamwa mopitirira muyeso. Mowa umapangitsanso kuchepa kwa shuga m'magazi. Magazi a shuga m'magazi pansi pa mamiligalamu 70 pa desilita yochepa kwambiri kwa anthu ambiri.

Zizindikiro zomwe zimachitika pang'onopang'ono, monga kupweteka pamutu, kutopa, ndi njala, nthawi zambiri zimakhala zosakwanira kukhala chizindikiro chenjezo. Zizindikiro za shuga wochepa wamagazi zimasokonezedwanso mosavuta ndi zizindikiro za kumwa mowa, zomwe zikutanthauza kuti kumwa mowa kumatha kudumphira kuchepa kwa shuga m'magazi.

Muzovuta kwambiri, zizindikirozi zimatha kukhala zowopsa m'moyo. Zizindikiro zakuchuluka kwa shuga wamagazi:

Kuyang'ana mozama,

Mantha kapena nkhawa

Mchere wotsika wamagazi umatha kuwongoleredwa ndi zowonjezera zam'magazi kapena mowa wa 15 g wa zovuta zosavuta, monga uchi kapena madzi a zipatso. Ngati shuga wa magazi sachira pakatha mphindi 15, ndiye kuti muyenera kuwonjezeranso Mlingo wowonjezera.

Kumwa mowa nthawi yogona kumatha kuchepetsa shuga m'magazi anu usiku. Anthu omwe ali ndi matenda ashuga ayenera kudya zopatsa mphamvu pambuyo pumwa mowa kuti apewe vutoli.

Metformin imachepetsa mayamwidwe a Vitamini B12, mowa umathandizanso kuyamwa kwa B12, kuchititsa kutupa m'mimba.

Kafukufuku wina akuwonetsa kuti metformin ikhoza kuwonjezera mwayi wokhala ndi vuto la kuchepa kwa vitamini B12 ndi 0.0001%. Komabe, chiwopsezocho chikhoza kukhala chachikulu kwambiri: 10-30% ya anthu odwala matenda ashuga a mtundu wa 2 omwe ali pa metformin amatha kuchepa kwambiri. Vitamini B12 ndi michere yofunika kwambiri yomwe imathandiza kwambiri matenda a mtima ndi minyewa. Vitamini B12 ndi gawo lofunikanso m'maselo ofiira a magazi.

Zizindikiro zokuchenjezani ndi zovuta za kuchepa kwa vitamini B12 zimaphatikizapo:

Kuchuluka kwa mankhusu kapena miyendo,

Kusintha kadyedwe kanu kumachepetsa zizindikiro za kuchepa kwa vitamini B12. Vitamini B12 imapezeka muzakudya monga ng'ombe, mazira, mkaka ndi zipolopolo.

Zolemba

1. Chingerezi P., Williams G. Hyperglycaemic crises and lactic acidosis inabetes mellitus // Postgraduate medical magazine. - 2004. - T. 80. - Ayi. 943. - S. 253-261.
2. Lepelley M. et al. Lactic Acidosis mu Chiwopsezo cha Anthu A shuga: Kodi Metformin Ili Yabwino? Zotsatira za Kafukufuku Wofananizira Kachitidwe Koyeserera Wochitidwa pa Type 2 Diabetes Population of Grenoble Hospital University // Buku la kafukufuku wa matenda ashuga. - 2016 .-- T. 2016.
3. Roberts C., Robinson S. P. Kuledzera kwa moledzera ndi kusungunulira kwa zakumwa: kukhudzidwa kwamisempha ya magazi a magazi // Zolemba zam'mbuyo ndi zamalamulo. - 2007. - T. 14. - Ayi. 7. - S. 398-405.

Munthu wamakono amawopsezedwa ndi matenda ambiri, ndipo amatha kuchezeredwa ndi aliyense. Zomwe zili zonse ndikuchepa kwakukulu kwa zochitika zachilengedwe, kuthamanga kwa moyo, kutopa kwambiri, kusowa tulo, kupsinjika ndi mantha. Chimodzi mwazomwe zimachitika kwambiri ndi matenda ashuga. Kuzindikira koyipa kumeneku kumamveka kale kwa anthu aku Russia miliyoni.

Zachidziwikire, anthu amakhala mwakachetechete komanso ndi matenda otere, amamwa mankhwala, ndikukwaniritsa zofunikira zonse zofunika. Madokotala nthawi zambiri amapereka mankhwala monga Metformin nthawi yoika odwala matenda ashuga. Mwa njira, mankhwalawa otetezeka agwiritsidwa ntchito mochizira matenda onenepa. Pazifukwa izi, odwala ena amati mankhwalawa ndi othandizira pazakudya ndipo amakhulupirira kuti Metformin ndi mowa zimagwirizana ndipo mutha kumwa mosavomerezeka poyambira chithandizo. Koma kodi zili choncho?

Kudziwana ndi mankhwalawa

Metformin ili m'gulu la zinthu zingapo zopangidwa ndipo imagwiritsidwa ntchito mochizira matenda a shuga mellitus II degree (mawonekedwe osadalira a insulin). Mankhwalawa ndi a gulu la mankhwala a hypoglycemic ndipo amatchuka chifukwa chothandiza kwambiri. . Ndemanga pa mankhwalawa zimatsimikizira izi.

Zomwe zimachitika mu Metformin zimaphatikizapo kuyendetsa bwino kwambiri kutengera zovuta zotsutsana ndi zoyipa (poyerekeza ndi mankhwala ena antidiabetes).

Kuyambira kumasulidwa kwake (1957), Metformin wakhala mankhwala otsogola pakusamalira shuga, makamaka ndi kunenepa kwambiri. Choyimira pakukula kwa adipose minofu ndi insulin. Mphamvu ya mankhwalawa imatha kuchepetsa kwambiri, ndipo, chifukwa chake, imathandizira kuchepetsa thupi. Chifukwa cha izi, anthu ambiri onenepa kwambiri amagwiritsa ntchito mankhwalawa pofuna kuchepetsa thupi.

Pharmacology ya mankhwala

Kuchita kwa Metformin kumadalira pakuimitsa njira yopopera shuga m'matumbo ndikufulumizitsa kuwonongeka kwake mu minofu ya zotumphukira. Zotsatira zake, mu plasma chizindikiro ichi chimatsika. Komanso, mankhwalawa samathandizira pakupanga insulin ndipo samapangitsa kuti achepetse kuchepa kwa maselo a pancreatic beta. Mankhwalawa amagwira ntchito motere:

1. Amachepetsa cholesterol.
2. Chimalimbikitsa kugwa kwa lipids.
3. Imakhazikika kulemera kwa thupi (ndi kuchuluka kwake).

Mapiritsi a mankhwalawa amatengedwa pamimba yopanda kanthu. Mutatha kumwa mapiritsi, muyezo wazakumwa zambiri zimawonedwa m'thupi pambuyo pa maola 1.5-2 (ngati piritsi linatengedwa mutatha kudya, pambuyo pa maola 2 mpaka 2-3). Hafu ya moyo wa zotsalira za mankhwala metabolites ndi pafupifupi maola 16 mpaka 17. Tiyenera kukumbukira kuti theka la moyo wa zotsalira za mankhwala lingachuluke pamaso pa kulephera kwa impso.

Kulembera

Ntchito yayikulu ya Metformin ndikuthandizira pochiza matenda a shuga mellitus II degree (osavulala a carbohydrate metabolism).Chida ichi chimagwiritsidwa ntchito makamaka kwa odwala omwe ali ndi kunenepa kwambiri (motsutsana ndi matenda oyambitsidwa), pomwe chithandizo chamankhwala sichisonyeza zabwino. Mtundu wa shuga wa I, Metformin amagwiritsidwa ntchito ngati cholumikizira chithandizo cha insulin choyambirira.

Kafukufuku waposachedwa atsimikizira kupambana kwa kugwiritsidwa ntchito kwa Metformin pothandizidwa ndi khansa zomwe zidayamba chifukwa cha matenda ashuga.

Metformin ndi yotchuka pakati pa anthu omwe amalota kuchepa thupi (ndipo si odwala matenda ashuga). Madokotala salimbikitsa kugwiritsa ntchito chida ichi ngati mtundu wowotcha mafuta, ngakhale chida ichi chimathandiziradi kuchepetsa thupi, chifukwa cha zinthu monga:

• kuthetsa mavuto
• kuchepa kwa chakudya chamafuta,
• mathamangitsidwe a makulidwe amakulu a adipose minofu,
• kuchuluka mayamwidwe glucose minofu minofu.

Koma pankhaniyi, ziyenera kukumbukiridwa kuti Metformin samawotcha mafuta amthupi, koma zimangoyambitsa kuwonongeka kwamafuta. Ndiye kuti, zolimbitsa thupi zolimbitsa thupi ndizofunikira. Kuphatikiza apo, sizinakhazikitsidwebe momwe mankhwalawo amathandizira munthu wathanzi, chifukwa chake sikoyenera kugwiritsa ntchito kwa anthu omwe akudwala matenda a shuga.

Mukuyenera kudziwa kuti malinga ndi chithandizo cha Metformin, muyenera kutsatira zakudya zina, zomwe zotsatirazi siziphatikizidwa ndi zakudya:

• mowa
• maswiti
• mbatata
• pasitala.

Contraindication

Tsoka ilo, ngakhale kuti thupi la wodwalayo limagwirizana kwambiri ndi mankhwalawa, sichotheka nthawi zonse kugwiritsa ntchito mankhwalawa. Metformin ili ndi zotsutsana. Sizingagwiritsidwe ntchito pazotsatirazi:

• uchidakwa wambiri,
• matenda kupuma
• mimba ndi mkaka wa m`mawere
• pachimake myocardial infaration,
• mukamadya zakudya zamafuta ochepa,
• aimpso ndi chiwindi kulephera,
• matenda a mtima
• zovuta zamagazi muubongo,
• ndi kufooka thupi (pambuyo pakuchita opaleshoni yayikulu, mabala, matenda ofooketsa),
• lactic acidosis (kapena lactic acidosis), imodzi mwazovuta za matenda ashuga, pakakhala kuchuluka kwambiri kwa lactic acid m'misempha ya thupi.

Zotsatira zoyipa

Ngakhale kutetezedwa kwake, Metformin imatha kubweretsa zovuta zina. Kwambiri, mavuto oterewa amachitika kuchokera m'mimba . Amawoneka motere:

• kutsegula m'mimba kwa nthawi yayitali
• chisangalalo ndi kuphuka,
• kupweteka m'mimba,
• kulawa kwazitsulo
• nseru, zomwe zimayambitsa kusanza kwambiri.
• kuchepa kwathunthu kwa chikhumbo ndi chitukuko pamaziko a anorexia awa.

Kugwiritsidwa ntchito kwa Metformin kumatha kuyambitsa zovuta komanso malabsorption a vitamini B12 ndi folic acid. Zotsatira zowopsa, koma zowopsa, madokotala amaphatikizapo matenda a metabolic, omwe amaphatikizidwa ndi lactic acidosis ndi glycemia. Izi zimachitika motere:

• dontho lakuthwa magazi.
• kugona tulo masana
• kupweteka kwa minofu ndi minyewa
• bradyarrhythmia (kutsitsa kwamkati ndi kusokoneza munthawi yomweyo kugunda kwa mtima).

Mitu ya mankhwalawa

Pankhani ya zovuta zoyipa, adokotala amatha kusintha Metformin ndi mankhwala ena omwe ali ndi vuto lofananalo. Zofananira zotchuka za mankhwala ophatikizira mankhwala ophatikizidwa ndi mankhwala monga:

• Siofor
• Bagomet,
• Fomu,
• Chikwanje,
• Glyformin
• Metfogamma,
• Diaformin OD,
• Glucophage Long,
• Metformin Richter,
• Metformin MV-Teva.

Metformin ndi mowa: kuyanjana

Kugwiritsa ntchito mafuta akumwa pakamwa ndi Metformin ndikutsutsana kwambiri. Zoletsa zazikuluzikulu za kuphatikiza kotereku zimaphatikizanso chiopsezo cha lactic acidosis, komanso kukulitsa mawonetsedwe ena oyipa.

Kukula kwa lactic acidosis

Metformin yokhala ndi zakumwa zoledzeretsa imakhala ndi zotsatirapo zoopsa, mowa nthawi zambiri umagawidwa mu shuga, makamaka mankhwala. Lactic acidosis ndi vuto lomwe lingayambitse wodwala matenda ashuga, limayamba kamodzikamodzi akamamwa mapiritsi, koma kumwa kwambiri kumawonjezera mwayi wa matenda.

Zinapezeka kuti kuphatikiza kwa mowa ndi Metformin pa mlingo wa 1 g / kg ya kulemera kwa thupi kumakwiyitsa kuchuluka kwa lactate (lactic acid) mwa nthawi 3-12.

Zizindikiro zoyambirira zokhala zoopsa ndi izi:

• kupumira msanga
• wopanda chidwi
• kusowa tulo usiku ndi kugona tulo masana.

Ndi kukula kwa matendawa, wodwalayo amawonetsa kusanza, kupweteka kwam'mimba komanso kuwonongeka msanga. Pamene matenda akuchulukirachulukira, kusokonezeka kwa chikumbumtima ndi minyewa kumakula.

Kuperewera kwa Vitamini

Chimodzi mwazinthu zoyipa zakukula kwa lactic acidosis ndikusowa kwama mavitamini a B mthupi . Mowa umakhala chifukwa cha izi ndipo umapangitsa maonekedwe monga:

• kuwonongeka mu mayamwidwe a vitamini B1 m'mimba
• Potengera maziko awa, kusowa kwa zinthu izi kumayamba,
• kuperewera kwa vitamini B-gulu kumabweretsa kukula kwa lactic acidosis.

Mkhalidwe wina womwe umakulitsa mwayi wa lactic acidosis. Hypoxia, motsutsana ndi kumbuyo komwe kuperewera kwa oxygen m'misempha ya thupi, kumawonjezera kuwoneka kwa matenda opha kangapo. Ndipo ndi ethanol yomwe imatsogolera ku hypoxia. Kumbukirani momwe mumasangalalira mutamwa kumwa - ndipo pambuyo pake, choyambitsa kupumulirako komanso chosangalatsa ndichosokoneza bongo. Matendawa amapezeka chifukwa chatsekeka mitsempha yamagazi ndimisempha - izi zimadziwika ndi gawo loyamba la kuledzera.

Kuwaza magazi ndi timagulu ting'onoting'ono ta magazi timene timapangidwa ndi gluing maselo ofiira amwazi. Cholinga chakudziphatika kwawo ndi mowa wa ethyl, womwe umachita mwanjira iyi pamagazi.

Matenda a impso ndi chiwindi

Kutsutsana kwathunthu potenga Metformin ndi uchidakwa. Ndipo munthawi imeneyi, mavuto akachitidwe ka chiwindi ndi impso nthawi zambiri amawonedwa. Mukaphatikiza chithandizo ndi mowa mwa wodwala, Metformin metabolites imachedwa, zomwe zimapangitsa kuti pakhale zovuta zina chifukwa cha bongo.

Kutengera izi, ntchito ya chiwindi ndi impso imavutika. Ethanol imalepheretsanso kugwira ntchito kwa ma enzymes a chiwindi, omwe pamaso pa matenda a shuga amapangitsa kukula kwa hypoglycemia.

Hypoglycemia ndi pathological syndrome, mkhalidwe wowopsa womwe umachitika ndi kuchepa kwamphamvu kwa glucose wamagazi.

Zotsatira zake, mowa ndi Metformin amatha kubweretsa wodwala kuti awoneke ngati kukomoka kwa hypoglycemic. Izi zimapangitsa munthu kusiya kuzindikira (ambiri amasokoneza munthu yemwe ali ndi chidakwa chachikulu). Ndipo nthawi zambiri, womwako amatsala yekha kuti "agone", pomwe akufunika thandizo kuchokera kwa madokotala. Ndi kukula kwa matendawa, gulu la ambulansi liyenera kutchedwa yomweyo. Madokotala asanafike, wovulalayo ayenera kumwa tiyi wokometsedwa ndi maswiti.

Zotsatira zoyenera kuziyembekezera

Poyerekeza zakumbuyo komwe kumamwa mowa nthawi yomweyo ndi Metformin (komanso mankhwala ofananawo), zizindikiro zotsatirazi ziyenera kuyembekezeredwa kwa wozunzidwayo:

• kufooka wamba
• chisokonezo,
• kupuma kosakhazikika
• Hyperventilation syndrome
• dontho lakuthwa magazi.
• kunyalanyaza, kusowa kachitidwe, kukondwerera.

Chodabwitsa cha hyperventilation ndi chiwonetsero chowopsa. Matendawa amapezeka motsutsana ndi maziko a kuchepa kwakukulu kwa mpweya m'magazi. Kuperewera kwa kaboni dayokisaidi kumayambitsa kuperewera kwa okisijeni ku minofu, zomwe zimapangitsa kuti pakhale hypoxia yayikulu.

Metformin ndi mowa: kumwa zochuluka motani

Mukamwa mowa, mutha kuyamba kulandira mankhwalawa pokhapokha ngati mukudwala kwambiri. Izi zimatheka pang'onopang'ono patatha masiku awiri ndi atatu kuyambira nthawi yomwe mumamwa. Mwa njira, sitiyenera kuiwala kuti mowa samangokhala zakumwa zoledzeretsa zokha, komanso mankhwala ena (makamaka osokoneza bongo) oledzera.

Ndi zoletsedwa kuyamba kulandira chithandizo ndi Metformin kale kuposa masiku awiri atamwa mowa kapena madzi / tincture wokhala ndi mowa.

Ponena za mwayi wakumwa atatha kuthandizira kochiritsira, pano mayankho amatengera zaka za wodwalayo:

• Achinyamata komanso athanzi ayenera kudikirira pafupifupi maola 18 mpaka 20,
• tsiku lenileni silinakhazikitsidwe kwa anthu okalamba, pankhaniyi muyenera kufunsa dokotala (izi zikugwiranso ntchito kwa anthu omwe akudwala matenda a chiwindi ndi impso).

Pa mankhwalawa pakokha, kupuma pakumwa sikulimbikitsidwa. Kumbukirani kuti mankhwalawa amatengedwa katatu tsiku lililonse kudzera munthawi yonse yomwe akupatsidwa. Chifukwa chake, ngati pali chikondwerero china chakumwa chakumwa chaukali, moyenera, mowa uyenera kusinthidwa ndi timadziti kapena zakumwa zamtundu uliwonse. Kupanda kutero, muyenera kusokoneza chithandizo, chomwe sichili njira yabwino yothandizira kukhudzika kwake.

Metformin yokhala ndi mowa wa matenda ashuga

Matenda a shuga amayamba chifukwa cha kufalikira kwathunthu kapena pang'ono mwa insulin m'magazi. Timadzi timeneti timayendetsa glucose komanso mgwirizano wake ndi maselo a ziwalo zamkati. Glucose ndi gwero lofunikira kwambiri lamphamvu kwa ziwalo zambiri. Mwachitsanzo, ubongo umapangidwa ndi mphamvu ya shuga. Tiziwalo zambiri komanso ziwalo zimatha kuzisintha pokhapokha mothandizidwa ndi insulin - izi zimadalira insulini. Ena amapirira popanda iyo - insulini -yokha. Ndi vuto la insulin, mtundu 1 wa shuga umayamba. Mtundu 2 umachitika pamene insulini siliyanjana ndi maselo amthupi. M'zochitika zonse zoyambirira ndi zachiwiri, mkhalidwewo ndiwopseza moyo, chifukwa shuga umangodziunjikira, ndipo ziwalo sizilandira mphamvu yayikulu. Mothandizidwa ndi Metformin, a 1 ndi 2 matenda a shuga amathandizidwa, chachiwiri, Metformin Richter nthawi zambiri amatchulidwa.

Magawo omwe amagwira ntchito a mankhwalawa amalimbikitsa njira ya glycolysis (kutsekeka kwa shuga ndi kutulutsidwa kwa mphamvu), kukonza magwiridwe a insulin ndi maselo. Tengani Metformin popanda mankhwala a dotolo ndiwotsutsana, chifukwa mankhwalawa ali ndi zotsutsana zambiri.

Kumwa mowa ndi matenda ashuga okha kungakhale koopsa. Mizimu yambiri imakhala ndi chakudya chamagulu, chomwe chimakulitsa shuga. Ndipo izi ziyenera kupewedwa kwambiri. Mutha kunena nthawi yomweyo kuti kumwa, odwala matenda ashuga, sikuletsedwa kwathunthu, chinthu chachikulu ndikusankha zakumwa zoyenera. Chifukwa chake, muyenera kusiya vinyo wokoma, ma cocktails, mowa wamdima. Zakumwa zatsopano zilizonse ziyenera kuyesedwa ndi glucometer. Vinyo wowuma amakhala ndi mafuta ochepa, motero si owopsa. Zomwezi zimagwiranso ntchito kwa mizimu yomwe ili ndi mphamvu 380 ndi pamwamba.

Izi ndizachidziwikire, za magawidwe oyenera a mowa. Kuphika muvinyo wowuma kapena makamaka vodika sikulimbikitsidwa ngakhale kwa anthu athanzi. Ngati atamwa mowa, odwala matenda ashuga amatha kukhala ndi hypoglycemia (kusowa kwa shuga m'magazi). Mowa wa Ethyl umalepheretsa kupezeka kwa shuga ndi chiwindi, izi pazokha sizowopsa, zotsatila zake zitha kukhala zoipitsitsa. Monga lamulo, shuga amabwezeretsedwa akangodwala shuga. Komabe, izi zimakwiyitsa kulumikizana kwakukukulu ndikuwopseza kuchuluka kwa shuga komweko. Chiwopsezo chachikulu chagona mu zizindikiro za hypoglycemia, chifukwa zovuta zaledzera zimafanana nawo. Pankhaniyi, nthawi zambiri munthu amakumana ndi:

• kulumikizana bwino ndi mawu,
• chizungulire
• kusanza ndi kusanza
• kuthamanga kwa magazi pankhope.

Chifukwa chofanana ndi zizindikiro, wodwalayo samalandira thandizo lofunikira, lomwe limakulitsa matenda omwewo. Glucometers, mwa njira, adapangidwa mu 1970 ndendende kuti athe kusiyanitsa pakati pa odwala omwe ali ndi shuga ochepa komanso zidakwa wamba.

Metformin ndi mowa zimapangidwa kuti zigwiritsidwe ntchito nthawi imodzi. Mankhwala sakudziwa bwino momwe amagwirizanira komanso momwe amagwirira ntchito mogwirizana. Komabe, zowona zimatsimikizira kuti odwala kuphatikiza mankhwalawa komanso kumwa pafupipafupi, chiopsezo cha mkaka acidosis chimawonjezeka. M'matenda akulu, matendawa amabweretsa kukomoka, ndipo zotsatira zakupha zidanenedwanso. Ngati magazi a wodwalayo atsika kwambiri, khungu limasinthasintha, nkhope zimakuthwa - muyenera kufunsa dokotala posachedwa.

Kuchuluka kwa zomwe mungamwe zimatengera nthawi yomwe mankhwalawo amamwa. Metformin iyenera kuchotsedwa kwathunthu kuchokera mthupi, njirayi imatenga pafupifupi maola 7. Ngati mowa wamwa, mapiritsi sayenera kumwa kwa maola ena 12. Wodwala ayenera kudziwa kuti kudumpha mankhwala kungakulitse matendawa. Koma pankhaniyi, ndibwino kuti tisapange ngozi yosakanikirana ndi mankhwala. Zotsatira zake zimakhala zowonekera komanso zovuta kwambiri.

Kuchokera pamiyeso yaying'ono ya mowa ndi mankhwala omwe amwedwa, kukulira kwa thanzi sikumawonedwa. Kungomwa kamodzi kwa mowa wochepa thupi (osapitirira 20 ml ya Mowa) sikungakhale ndi zotsatirapo zoopsa. Ndikofunika kukumbukira mukamamwa Metformin kuti muyenera kusamala kwambiri ndi kuchuluka kwa mowa ndi mtundu wake.

Metformin yochepetsa thupi: kuphatikiza mowa

Kuphatikiza pa kugwiritsidwa ntchito mwachindunji, Metformin imagwiritsidwa ntchito pakuchepetsa thupi. Imalimbikitsa kukhathamiritsa kwa mafuta acids, kumachepetsa chilimbikitso ndi mayamwidwe am'madzi. Komabe, kuwunika kwa omwe akuchepetsa thupi kukuwonetsa kuti zotsatira za kuwongolera kotereku zingakhale zosiyana. Nthawi zambiri, omwe akufuna kumanga mwachangu amakhala ndi mankhwala osokoneza bongo kapena amangogwiritsa ntchito molakwika.

Kugwiritsa ntchito mankhwala osavomerezeka ndi dokotala ndi koopsa kwambiri. Pali njira zambiri zochepetsera kunenepa popanda kuyika zotsatira zoyipa. Mwa awa:

• kupweteka m'mimba
• kugaya chakudya
• kusanza ndi kusanza
• chizungulire komanso kusazindikira.
• acidosis (m'malo ovuta kwambiri).

Kwa munthu wathanzi, ndibwino kufunsa katswiri wazakudya musanagwiritse ntchito mankhwalawa ndikupeza ngati angatenge.

Mwa anthu onenepa kwambiri chifukwa cha matenda ashuga, mankhwalawa amachepetsa shuga. Mwa munthu wathanzi, chizindikiro ichi sichimasintha mwanjira iliyonse. Palibe chifukwa choti Metformin igwiritsidwe ntchito ndi anthu omwe ali ndi:

• matenda opatsirana
• kulephera kwa chiwindi
• tsankho pamagawo a mankhwala,
• mtima wosagwira.

Komanso, iyenera kupewedwa pa mkaka wa m'mawere ndi pakati.

Mankhwala palokha sangatenthe mafuta. Chida ichi chimadziwika ndi othamanga komanso omanga thupi, chifukwa chimawathandiza kugwiritsa ntchito mphamvu kuchokera kumagulu amafuta, osati kuchokera ku minofu minofu. Chifukwa chake, Metformin imangothandizira kuchepetsa kunenepa. Kwa iwo omwe samavutikira ndi zolimbitsa thupi, mankhwalawa sangathandize. Mndandanda wazolowera masewera ukhoza kuphatikiza ogwiritsa ntchito zolimbitsa thupi, chifukwa momwe kugwiritsidwira ntchito kudzakhala koyenera.

Chachikulu pa "zakudya za metformin" zonse zimakhutira ndi omwe amakhulupirira kuti kumwa mankhwalawo ndikokwanira kuti muchepetse kunenepa. Kuchepetsa thupi kumachitika makamaka chifukwa cha zinthu zoyenera komanso masewera olimbitsa thupi. Ngati mupitiliza kudya zakudya zama calorie ambiri mukamamwa Metformin, palibe zotsatira zomwe zingakambidwe. Koma kusala kudya mwachangu kumatsutsana. Malangizo a mankhwalawa akuwonetsa kuti kudya kalori tsiku lililonse kuyenera kukhala osachepera 1000 kcal.

Pazakudya zoonda zomwe zimakhala ndi shuga sizimachotsedwa mu zakudya.Pansi pa chiletso: mphesa, nthochi, beets, kaloti, ndi zina zotero. Kuphatikiza apo, muyenera kusiya mbatata, mankhwala a ufa, oatmeal ndi mpunga wopukutidwa woyera.

Mapiritsi amatengedwa musanadye, 500 mg katatu patsiku. Pulogalamuyi sitha kupitirira masiku 20. Pambuyo pake, pumulani kwa miyezi iwiri. Kuphatikiza kwa zakudya ndi mowa, kumene sikulimbikitsidwa.

Mowa siwothandiza kwambiri pomenyera chithunzi chabwino. Kamodzi m'thupi, mowa wa ethyl umawoneka ngati wofunikira kwambiri. Thupi limazindikira kuti ndiwopseza ndipo limayesayesa kulichotsa mwachangu. Pomwepo, "kudya" chakudya, m'malo mopsinjika ndi mphamvu, chimayikidwa pambuyo pake, m'matumba a adipose. Ndiye kuti, kumwa mowa kumathandizira kuti pakhale kuchuluka kwa zakudya ndipo zakudya zonse ndizopanda tanthauzo.

Kuphatikizidwa kwa Metformin ndi zakumwa zoledzeretsa kumakhumudwitsidwa kwambiri ngakhale ndi anthu athanzi. Monga tawonetsera kale, kuyanjana kwa zinthuzi sikunaphunziridwe kwathunthu, motero zotsatira zake sizingachitike. Malangizo a mankhwalawa akuwonetsa kuti kumwa mankhwalawa pambuyo poyamwa poizoni kumatsutsana kwambiri. Ndiye kuti, ngati tsiku laphwando lili ndi mowa wambiri, ndikofunikira kudikira mpaka kuchotsedwa kwathunthu kwa Mowa m'thupi. Kwa akazi - masiku awiri. Kwa amuna - masiku atatu. Pambuyo pa kuchepa kwa thupi kumatha kutha, mutha kumamwa pakatha masiku osachepera 3-5.

Mapeto: ndizotheka kuphatikiza Metformin ndi mowa

Kugwirizana kwa mankhwalawa ndi mowa womwe umaganiziridwa sikumadziwika. Komabe, madokotala salimbikitsa kusakaniza zinthu izi. Kwa odwala omwe ali ndi giredi 1 ndi 2 matenda a shuga, kumwa zakumwa nthawi zambiri kumapha. Ndipo, akaphatikizidwa ndi mankhwala mwa odwala otere, chiopsezo cha lactic acidosis chimawonjezeka. Kwa odwala matenda ashuga, ndikofunikira kudziwa kuchuluka kwa zakumwa zoledzeretsa komanso kumwa zakumwa zosapatsa shuga zilizonse, pomwe kumwa mankhwalawa kumakhala kosavomerezeka kwa pafupifupi maola 12.

Omwe omwe akungoyesa kuchepetsa thupi sayeneranso kuyeseza thupi lawo, kuphatikiza Metformin ndi mowa. Zotsatira za izi zitha kungokhala osasangalatsa kapena kukula kwa matenda omwe kale sanali nawo. Potsirizira pake, kuchepetsa thupi kuyenera kuthana ndi vuto lalikulu kwambiri kuposa kukonza manambala. Pankhani yakugwiritsa ntchito milingo yaying'ono ya mowa, mapiritsi amatulutsidwa.

Chifukwa chake, simuyenera kumwa mowa ndi mankhwala (ambiri) kuti mukhale ndi thanzi. Pambuyo pa "ufulu" wachiwawa komanso kuledzera kwambiri, Metformin sangatengedwe kwa tsiku lina kapena awiri. Mutatha kumwa mankhwalawa, mutha kumwa pambuyo pa maola 7. Mowa, ndikofunikira kudziwa muyeso, ndiye kuti zotsatirapo zosasangalatsa zidzadutsa.

Lactic acidosis

Vutoli limakhala ndi zakupha, mwamwayi, ndizosowa kwambiri, koma ngati wodwalayo samamwa mowa. Kuphwanya izi zoletsa, chiopsezo cha lactic acidosis chimawonjezeka nthawi zina.

Zakumwa zoledzeretsa zimapangidwa mwanjira yapadera, zomwe zingayambitse kuchuluka kwa lactate ngakhale mwa munthu wathanzi kwathunthu. Kuchita koteroko ndikofunikira kuti mphamvu yopulumutsidwa igwiritsidwe ntchito pa metamorphosis ya ethanol kuti acetaldehyde.

Ntchitoyi imatsimikiziridwa ndi kuyesa: ngati Metformin ndi ethanol amagwiritsidwa ntchito panthawi imodzi 1 mg / kg, ndiye izi zidzapangitsa kuti 3act-lactate iwonjezeke.

Kuperewera kwa Vitamini

Chifukwa choyamba chomwe zinthu zakumwambazi zimakhalira ndikusowa kwa vit. B1. Ndizodziwika bwino kuti zakumwa zoledzeretsa zimasokoneza kuyamwa kwa vitaminiyu m'mimba, pomwe zakumwa zoledzeretsa sizimapezeka.

Wodwala akamamwa mowa, padzakhala:

• Mafuta a B1 m'matumbo am'mimba amawonongeka
• Kufunika kwa vitamini kumachulukira kwambiri
• Mkhalidwe wopanda thupi
• Chiwopsezo cha lactic acidosis chidzachuluka kwambiri.

Hypoxia ndi njala ya oxygen. Nthawi zambiri, kukula kwa acidosis ndi zotsatira za kuchepa kwa minofu ya oxygen. Potere, ngati mumamwa mowa, ndiye kuti hypoxia ya ubongo idzachitika. Zomwe zimayambitsa zili m'mitsempha yamagazi ndimagazi, kuchepa kwa oksijeni kumayambitsa chisangalalo, chomwe aliyense amakhala atamwa.

Kugundika kwa magazi kumatchedwa kuundana kwa magazi komwe kumapangidwa chifukwa chogwirizanitsa kuchuluka kwa maselo ofiira amwazi. Zomwe zimayambitsa zimachitika ndi zakumwa, zomwe zimalowa m'magazi athu tikamamwa vinyo wokwera mtengo komanso wotsika mtengo, vodika, cocktails, mowa, etc. Mowa wonse womwe uli ndi zakumwa zoledzeretsa zili ndi chinthu chachikulu - mowa wa ethyl.

Impso zolakwika

Chofunika kwambiri chobera chifukwa chomwe Metformin ndi mowa umaletsedwera ndi matenda a impso oyambitsidwa ndi uchidakwa.

Ngakhale kugwiritsa ntchito kamodzi kwa mankhwalawa ndi mowa mwa iwo omwe alibe matenda omwe akufotokozedwa kumatha kuchepetsa ziwalo, mwakutero zimapangitsa kuchepa kwa mankhwalawo. Izi, zidzatsogolera ku bongo wambiri ndikukula kwa zotsatira zowopsa.

Chowonadi ndi chakuti ethanol imapanga katundu wambiri pama enzymes a chiwindi, ndikupangitsa hypoglycemia. Zotsatira zophatikiza mankhwalawa ndi mowa zimatha kukhala chikomokere.

Imaphatikizidwa ndi swoon, yosavuta kusokoneza ndi mkhalidwe woledzera kwambiri. Anthu ozungulira, akufuna zabwino kwambiri, adzagonetsa oledzera, koma kwenikweni pakadali pano ndikofunikira kupereka chithandizo choyamba ndikuyembekezera kuti ambulansi ifike.

Zotsatira zake

Kutengera kwa Metformin ndi mowa kumatha kubweretsa lactic acidosis.

Zizindikiro zake ndi izi:

• Kutsitsa magazi
• Chisokonezo
• Zofooka zambiri
• Chisoni
• Kutaya kulumikizana ndi ena
• Nthawi zambiri amapuma.

Zotsatira zoyipa ndi hyperventilation, yomwe imatsatana ndi kuchepa kwa kuchuluka kwa kaboni dayokisi m'magazi.

Kuphatikiza kwake kochepa sikungakwanitse kupereka zokwanira ndi mpweya, chifukwa hemoglobin, ngakhale imamangilira mpweya wabwino, siyingathe kuifalitsa. Chifukwa chake, hypoxia imachitika.

Ndingaphatikizire pati

Ngati, komabe, posakhalitsa muli ndi mtundu wina wa chochitika chomwe sichingagawidwe, ndiye ndikofunikira kudziwa kuti mutamwa Metformin nthawi yayitali bwanji.

Mwa malamulo onse, maola 48 ayenera kudutsa pakati pa kumwa mowa. Izi ndizomwe zimafunikira kuti ubwezeretse impso.

Mowa si zakumwa zokha, cocktails, cognacs, vin, etc., komanso mankhwala aliwonse omwe ali ndi mowa!

Chifukwa chake, ngati masiku osakwana 2 adadutsa kale kuchokera kuti kulowetsedwa ndi ethyl mowa, ndiye kuti Metformin ndi yoletsedwa.

Mu chamoyo chaching'ono, nthawi ino amatha kuchepetsedwa mpaka maola 18. Kwa okalamba, T1 / 2 sichinakhazikitsidwebe. Izi zikutanthauza kuti kuchoka kwa mankhwalawo ndikovuta, kumakhalabe m'thupi motalikirana, motero, ndizothekanso kugwiritsa ntchito mankhwalawo mukufunsidwa.

Kutengera kuti Metformin akuwonetsedwa kuti azilandira masiku onse atatu, ndizosatheka kusangalala ndi zakumwa zoledzeretsa panthawi yonse ya mankhwalawa ngati simukusokoneza mankhwalawo.

Malingaliro a akatswiri onse ndi ofanana - kugwiritsa ntchito Metformin pakumwa anthu ndizoletsedwa!

Osatengera chidwi ndi iwo omwe adamwa mankhwalawo. Chowonadi ndi chakuti ambiri a iwo amamwa mankhwala kuti athetse mapaundi owonjezera. Ndiwachichepere, ali ndi impso wathanzi, zakudya zoyenera ndi ziwiya zolimba. Mwina anali ochita bwino, ndipo sanamve zowononga zakuphatikiza.

Kodi Metformin ndi chiyani?

Metformin ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda ashuga. M'mbuyomu adadziwonetsera kuti ali wabwino kwambiri. Amadziwikanso m'masitolo ogulitsa mankhwala pansi pa mayina monga: Dormin, Glucophage, Glucophage.Chuma chake chachikulu ndikuchepetsa kudalira kwa insulini komanso kupewa kunenepa kwambiri. Mankhwalawa sangasinthe kuchuluka kwa insulin ya m'magazi, koma imatha kusintha momwe imagwirira ntchito. Mphamvu yogwira imalepheretsa kuphatikiza kwa glucose kuchokera m'mafuta ndi mapuloteni, imathandizira kusintha kwa kusintha kwake kukhala zinthu zina zofunika ndikuchepetsa shuga.

Kuphatikiza pa kuchiza matenda a shuga, Metformin imagwiritsidwa ntchito ndi anthu athanzi kuti achepetse thupi. Koma chifukwa chakuti, mosiyana ndi anthu odwala matenda ashuga, njira zosiyana siyana zimapezeka m'maselo a anthu athanzi, mutha kuzigwiritsa ntchito kwa nthawi yochepa ndikutsatira malamulo ena. Kodi metformin imalowa bwanji m'thupi la munthu? Ndi zovuta ziti zomwe zimatha kugwiritsa ntchito Metformin ndi mowa? Nokha, ndimankhwala ovuta, ndipo nthawi zina mukamalandira chithandizo, zovuta za metabolic, zomwe zimatchedwa lactic acidosis, zimatha kuchitika. Kutenga Metformin, ndikuwoneka kuti wodwalayo ayamba kumva kuti ali ndi mseru, amakhala ndi matenda am'mimba komanso osasangalala. Nthawi zina, wodwalayo amayamba kukhala lactic acidosis.

Ngati munthuyu amamwa mowa, ndiye kuti mwayi wake 'wosadabwitsa' ndiwokwera kwambiri. Metformin ndi mowa ndizoletsedwa kumwa nthawi yomweyo, chifukwa chifukwa chopusa chotere wodwalayo atha kukhala ndi zotsatira zakupha kapena kukula kwa matenda ovuta. Chidacho chokha ndi mankhwala ovuta, ndipo nthawi zina mukamalandira chithandizo chingayambitse zosokoneza.

Nazi zina mwa zovuta zomwe zingachitike:

1. Zosokoneza pamimba. Mukangomwa mowa, thupi limayamba kupanga poizoni, yemwe amachititsa kutupa kwa kapamba ndi mucous membrane wam'mimba, esophagus, etc. Zotsatira zake, kusanza, kupweteka mutu, ndi matenda am'mimba kapena kudzimbidwa kumatha kuchitika. Kuphatikiza apo, pali kuthekera kwa kupweteka kwambiri pamimba. Mukangoyamba kumene zizindikiro izi, pitani kuchipatala.
2. Kulephera kwa ntchito yamanjenje. Zizindikiro za izi zitha kukhala mawonekedwe akunja a munthu. Pakakhala kulephera, kulumikizana m'malo m'malo osokonezeka, ziwalo kapena kunjenjemera miyendo kumatha kuchitika. Ena sangamvetsetse zomwe amalankhula, koma iye sangazindikire. Ngakhale wodwalayo amatha kugwedezeka, ma tics, komanso ma migraines, kuyerekezera zinthu zina, kupweteka m'thupi lonse. Ndizotheka kuti wodwalayo azidwala khunyu kapena asambe. Pankhaniyi, kudzithandiza nokha kudzakhala kovuta kwambiri, chifukwa chake muyenera kuyitanitsa madokotala.
3. Matenda a mtima. Mutatenga Metformin ndi mowa nthawi yomweyo, kuthamanga kwa magazi kumakhazikika nthawi yomweyo, kupuma movutikira kumawonekera. Pankhaniyi, munthu akhoza kuyamba thukuta kwambiri, amatha kumva chizungulire, kudzikayikira, komanso kusokonezeka kwa chikumbumtima ndikothekanso. Ndikumangopitiliza kumwa mowa limodzi ndi Metformin, mavuto monga matenda a mtima, matenda a mtima, myocardiopathy, ndi ena amatha.

Kodi ndingamwe mowa pambuyo pa Metformin? Ndizachidziwikire kuti Metformin ndi mowa ndizoletsedwa kumwa nthawi yomweyo, chifukwa pali mwayi wawukulu wokufa. Izi zimachitika chifukwa chakuti mankhwalawa akamamwa kuchokera m'matumbo am'mimba. Mowa umayamba kusakanikirana ndi magazi pafupifupi ikangolowa mthupi. Titha kumaganiza kuti mukamamwa mankhwalawo zidzakhala zokwanira kudikirira maola 6-7 kuti mumwe mowa, koma sizili choncho. Mowa mu thupi la odwala matenda ashuga umayamba kuletsa ntchito za michere ina ya chiwindi, yomwe imayambitsa hypoglycemia. Komanso kukula kwa m'mimba kumakhudzanso kumwa kwa mowa. Chifukwa chake, kuti muchepetse kukhazikika kwa lactic acidosis, muyenera kudumpha mosiyanasiyana.Komabe, odwala matenda ashuga ayenera kumwa mankhwalawa nthawi zonse, chifukwa kuchotsera kumatha kubweretsa imfa kapena chikomokere.

Kwenikweni, ngati mungafufuze zonse zomwe tafotokozazi, mutha kunena motsimikiza kuti mulibe vuto lililonse kuti musakanize mankhwalawa ndi zakumwa zilizonse zamphamvu, apo ayi zimabweretsa imfa kapena matenda akulu omwe amavuta kuchotsa.

Kodi Metformin ndi chiyani, kapangidwe kake ndi mfundo zake zoyenera kuchita

Awa ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda amishuga amtundu wa 2, omwe ali ndi mawonekedwe oletsa insulin mwa anthu onenepa kwambiri.

Mitundu yopangira chachipangizachi ndi mapiritsi okhala ndi zokutira zapadera komanso zinthu zosiyanasiyana zogwira ntchito: 500, 850 ndi 1000 mg, zogulitsidwa pamatoni a makatuni 30, 60 ndi 120. Mapiritsiwa amakhala ndi zokutira ndi chipolopolo choyera, ali ndi mawonekedwe ozungulira kapena owondera, okhala ndi biconvex, mbali imodzi ya piritsi ili pachiwopsezo kapena itha kukhalapo.

Kuphatikiza pazomwe zimagwira, pakupanga mapiritsiwa pali zinthu zina monga: magnesium stearate, starch ya chimanga, povidone, talc ndi crospovidone.

Kugwiritsa ntchito mankhwalawa kumayimitsa kayendedwe ka shuga m'matumbo ndikuthandizira njira ya kuphipha kwake. Izi zimachepetsa kuchuluka kwa shuga m'magazi. Mankhwalawa samathandiza pakupanga insulin, sikufafaniza kuthekera kwa maselo a beta a kapamba. Limasinthasintha cholesterol, kuchuluka kwa lipids yamagazi ndikuthandizira kuchepa.

Zizindikiro zochizira za kuchuluka kwa mankhwalawa m'magazi, zikagwiritsidwa pamimba yopanda kanthu, zimatheka mkati mwa maola awiri. Ngati mumadya mukatha kudya, ndiye kuti mumatha maola awiri ndi theka.

Kuchotsa mankhwalawa m'thupi kumachitika makamaka kudzera mu impso. Kuchotsa hafu ya moyo ndi pafupifupi maola khumi ndi asanu ndi awiri ndi theka.

Mukamagwiritsa ntchito anthu omwe akudwala matenda a impso, nthawi yochotsa theka imatha nthawi yayitali chifukwa kuchepa kwa chilolezo cha impso, ndiye kuti kuthamanga kwa magazi kumachepa.

Ndani angagwiritse ntchito mankhwalawa

Kugwiritsa ntchito mankhwalawa kumawonetsedwa kwa anthu omwe amapezeka ndi mtundu wachiwiri wa matenda a shuga, komanso akudwala kunenepa kwambiri. Makamaka pamene ndizosatheka kwathunthu kuchotsa mapaundi owonjezera, kuyamba zakudya zosiyanasiyana.

Komanso, mankhwalawo amawonetsedwa kwa odwala omwe ali ndi matenda a shuga omwe amakhala ndi mtundu wachiwiri, omwe ali ndi kunenepa kwambiri komanso kukana insulin.

Mankhwalawa amayenera kumwedwa nthawi yomweyo ndi insulin.

Ndani akupangidwa kuti agwiritse ntchito?

Gulu lowopsa, lomwe limaletsedwa kumwa mankhwalawa, limaphatikizapo anthu omwe akuvutika ndi:

• tsankho pamagawo a mankhwala,
• matenda ashuga ketoacidosis, ali munkhwawa komanso akomoka.
• kukhala ndi pakati komanso kuyamwitsa,
• uchidakwa
• Kulephera kwa impso kapena chiwindi,
• pambuyo pakuvulala ndi pambuyo pa ntchito pamene mankhwala okhala ndi insulin amagwiritsidwa ntchito ngati mankhwala.
• osakwanira mapapo kapena mtima, kuchepa kwamkati,
• Pazakudya zopatsa mphamvu zochepa,
• zaka zopitilira 60 pa nthawi yomweyo, kuchita masewera olimbitsa thupi kwambiri.

Kodi yogwira ntchito ya Metformin ndiyotenga nthawi yayitali bwanji?

Metformin ndi m'gulu la Biguanides. Mankhwala amachepetsa shuga. Izi zimatheka ndi:

• kutsika kwa gluconeogeneis - kuchuluka kwa shuga m'magazi,
• kuchuluka kwa chidwi cha minofu ya glucose,
• kupindika kwa glucose
• kukondoweza kwa lipolysis - kukhathamiritsa kwa mafuta acid,
• kuchepetsa mayamwidwe a shuga m'mimba.

Kuphatikiza apo, mukamagwiritsa ntchito Metformin:

• kuchuluka kwa triglycerides kumachepa,
• Mankhwala ndi activator wa plasminogen, amene amathandiza kuchepetsa magazi kuzungulira ndi kutsekeka kwa matenda a mtima kukula.

Mankhwala amaperekedwa pakamwa. Mlingo ndi njira zamankhwala zimatsimikiziridwa ndi adokotala, kutengera zomwe zikuwonetsa kuti kusala kudya kwa shuga.

Metformin imakhala kuti imalowa m'magazi athunthu. Izi zimachitika patatha maola 2,5.

Kudya ndi mankhwalawa kumachepetsa mayamwidwe ndi 40-45%, ndipo nthawi yofika kwambiri m'magazi imachulukitsa pafupifupi mphindi 30 mpaka 35.

Wapakati bioavailability ndi okwera ndipo pafupifupi 50-55%. Kutulutsa kambiri komwe kumagwira ntchito m'magazi pamlingo wa 1 μg / ml kumapitirira kwa maola 24- 48. Metformin, pafupifupi, imatha pafupifupi maola 24. Nthawi iyi imatha kusiyana maola 7 mpaka 48, motero kupereka yankho lomaliza la funso loti mankhwalawo amagwira ntchito nthawi yayitali bwanji zovuta.

Mankhwala zimapukusidwa mu chiwindi. Mankhwala amathandizira enzyme AMPK, yomwe imayambitsa insulin, mphamvu yochepa ya thupi komanso kagayidwe ka glucose ndi mafuta. Chifukwa chake, kuchepa kwa gluconeogenesis m'chiwindi kumezedwa.

Kuzindikira kwa shuga - ingomwani tsiku lililonse.

Kodi Metformin ndi Mowa Zitha Kuphatikizidwa

Metformin sigwirizana kwathunthu ndi mowa. Kuphatikiza apo, mukamwa mankhwalawa, sikulimbikitsidwa kugwiritsa ntchito zinthu zomwe zimakhala ndi Mowa, mwachitsanzo, tincture wa echinacea. Izi zikufotokozedwa ndi chiwopsezo cha lactic acidosis, yomwe imachulukitsa nthawi zambiri ndi kuledzera.

Zimatsata kuti kutenga Metformin ndi mowa ndizoletsedwa!

Lactic Acid Lactic Acidosis

Lactic acidosis ndi mkhalidwe momwe kuchuluka kwa lactic acid mthupi kumakhala kokwanira kwambiri, koma palibe mwayi wokukonza. Izi zitha kubweretsa mavuto akulu. Chithandizo choyambirira chimathandizira kuti muchepetse zovuta. Izi zimafuna kuzindikira koyenera.

Zowonetsera zomwe zimadziwika kwambiri pamkhalidwewu ndi:

• kupweteka pachifuwa
• kuchuluka kwa mtima
• kugunda kwa mtima
• kutayika kwa kuganiza bwino
• ictericity (chikasu) pakhungu ndi maso.

Ndi kukula kwambiri kwa lactic acidosis, zotsatirazi zimawonedwa:

• kupweteka kwa minofu
• kukokana
• zovuta zonse
• kupweteka m'mimba
• kumva kutopa ndi mphamvu.
• kugona
• matenda am'mimba, nseru, kapena kusanza,
• cephalgia (mutu).

Makina a pathology iyi amagwirizana kwambiri ndikuphwanya kuzungulira kwa ma Krebs.

Timapereka kuchotsera kwa owerenga tsamba lathu!

Kuzungulira kwa Krebs ndi gawo lofunikira kwambiri panjira zambiri za metabolic, zomwe zimayambitsa kupuma kwa mpweya wa zimakhala (amatchedwanso kuti kupuma).

Kuphatikiza pa kupuma ntchito, imayang'anira ntchito yolowera zinthu zomwe zimapangidwa pa glycolysis mu waya wamagetsi. Omaliza, mothandizidwa ndi ma elekitironi amenewa, amasunga mphamvu mu cell. Amaperekanso zotsogola zam'mbuyomu zomwe amapangira amino acid, chakudya, mafuta acids, etc.

Kuti mayendedwe a Krebs agwire ntchito, muyenera gawo lapansi - acetyl-coenzyme A (acetyl-CoA), omwe amapangidwa kuchokera ku pyruvic acid wokhala ndi mpweya wokwanira ndi pulodyeni ya encyme ya pyruvate dehydrogenase.

Ngati pali mpweya wochepa, ndiye kuti pyruvic acid imasweka ndikupanga lactic acid. Kuperewera kwa insulin kumalepheretsa pyruvate dehydrogenase, chifukwa chake asidi wa pyruvic amaphwanya njira yopanda mpweya.

Kugwiritsidwa ntchito kwa Biguanides kumabweretsa gawo logwiritsira ntchito lactate m'chiwindi ndi minofu, komwe kumayambitsa lactic acidosis, yomwe imadutsa metabolic acidosis.

Mowa, chifukwa cha makutidwe ndi okosijeni omwe amapezeka m'maselo a chiwindi, umasuntha mawonekedwe ofanana panthawi yomwe makutidwe ndi okosijeni a pyruvate kupita ku lactate. Izi zimathandizira kuthekera kwa Metformin kudziunjikira lactate.

Hypoglycemia

Mowa ungayambitse hypoglycemia. Vuto lowopsa kwambiri lomwe limachitika ndi matenda oopsa kwambiri. Ubongo suulandila gawo lalikulu, ntchito yake imasokonekera ndipo munthuyo amakhala wopanda vuto.

Zoyambitsa mowa hypoglycemia:

• mowa umaletsa gluconeogeneis,
• glycogen depletion,
• kutsika kwa plasma glucose.

Mowa hypoglycemia nthawi zambiri umatha kumwa mankhwala okhala ndi ethanol pamimba yopanda kanthu.

Kuphwanya mayamwidwe mavitamini

Metabolism ya Ethanol imathandizira kuchepetsa kuyamwa kwa thiamine (B1). Vitamini B1, wogwira ntchito, ndiye coenzyme wamkulu pakusintha kwa pyruvic acid kudzera munjira ya oxygen. Ndi kuchepa kwake, njira yopanda mpweya imayatsidwa ndipo mkaka wake umapangidwa.

Mowa waukulu waukulu umatha kuyambitsa ubongo hypoxia - uku ndikosakwanira kwa oxygen m'matupi. Chifukwa cha pathology, intracellular metabolism imasokonekera, khungu silingathe kuchita ntchito zake, izi zimayambitsa kuwonongeka kwa ntchito ya minofu ndi kufa kwake kwapang'onopang'ono.

Popeza kuperewera kwa okosijeni ndikofunikira kwambiri kwa lactic acidosis, hypoxia motsutsana ndi maziko a mowa imawonjezera zomwe zili lactic acid.

Mphamvu ya zakumwa

Nthawi yotetezeka kwambiri pambuyo pake yomwe mungamwe mowa mutamwa Metformin ndi masiku 1-2. Ngakhale zili choncho, muyenera kusokoneza chithandizo kwa nthawi yoposa tsiku limodzi, chifukwa pafupifupi mowa umachotsedwa m'thupi mkati mwa maola 3 mpaka 14.

Izi zimatheka chifukwa cha ubale womwe ulipo pakati pa mlingo, kulemera ndi jini la munthu, komanso gawo la kagayidwe ka chiwindi.

Kusagwirizana kwa Metformin kumakhudzana kwambiri ndi kupitilira kwa matenda ashuga ndipo ndimakhumudwitsidwa kwambiri.

Komabe, pamabwalo odzipereka pankhaniyi, ambiri amasiya ndemanga pomwe amalangiza kuti asaganizire zomwe zingachitike chifukwa mwayi wawo ukule kwambiri. Njira zopambanitsa kotere si zofunika.

Komabe, munthu nthawi zambiri amakumana ndi malingaliro akuti "onedrink" kapena "chakumwa chimodzi." Izi ndi 14 g za mowa wabwino, womwe umatha kuledzera osavulaza. Mukumwa Metformin, mowa umodzi (mowa 5%) sayenera kupitirira 350 ml, vinyo - 140 ml, ndi vodka - 40 ml.

Njira zopewera kupewa ngozi

Kuti muchepetse chiwopsezo chokhala ndi mavuto akulu, muyenera kutsatira malangizo osavuta:

1. Ngati ndi kotheka, siyani kugwiritsa ntchito nthawi yomweyo mowa ndi Metformin.
2. Yang'anani kuchuluka kwa shuga m'magazi.
3. Ngati mukufuna kumwa mowa, kaonana ndi dokotala.
4. Zakumwa zoledzeretsa pamodzi ndi chakudya.
5. Mukamwa mowa, imwani vitamini B1 masiku angapo.

Mulimonsemo, chithandizo cha odwala matenda ashuga chiyenera kubwera choyamba. Chifukwa chake, ndikwabwino kusiya kakhalidwe koipali.

Matenda a shuga nthawi zonse amayambitsa zovuta zakupha. Mwazi wamagazi ochulukirapo ndi woopsa kwambiri.

Aronova S.M. adafotokoza za chithandizo cha matenda ashuga. Werengani kwathunthu

Kusintha ndi lactic acidosis

Matendawa amafa ndi matenda ashuga, osowa kwenikweni ngati wodwala samamwa mowa. Mukamamwa zakumwa zoledzeretsa, ngozi ya lactic acidosis imawonjezeka kwambiri.

Mowa umapangidwa mwanjira yoti utha kuchititsa kuchuluka kwa lactate ngakhale mwa munthu wathanzi labwino. Thupi liyenera kuchepetsera kagayidwe kazakudya pomayamwa kuti muthe kugwiritsa ntchito mphamvu zosungidwa pakusintha kwa ethanol kukhala acetaldehyde.

Vutoli limatsimikiziridwa poyesa - munthawi yomweyo kugwiritsa ntchito Metformin munjira yothira mankhwalawa ndi ethanol mu 1 g / kg imapangitsa kuchuluka kwa lactate m'magazi ndi katatu mpaka katatu.

Mowa hypoxia monga chifukwa cha lactic acidosis

Hypoxia, kuperewera kwa mpweya wabwino m'matumbo, kumatha kupangitsa kukhazikitsa lactic acidosis. Ndikofunikira kwambiri kuti pakumwa mowa, ubongo umatha.

Ndi ubongo hypoxia yomwe imachitika chifukwa cha kufooka kwa mitsempha yamagazi ndimagazi omwe amawaganizira kuti ndi omwe amachititsa kuti euphoria ifanane ndi gawo loyamba la kuledzera.

Kuwaza magazi ndi zigawo zamagazi kuchokera kumamatira a m'magazi ofiira.Micotrrombi yotere imatuluka mothandizidwa ndi ethanol yomwe yalowa m'magazi pambuyo p kumwa zakumwa zoledzeretsa zilizonse - mavinidwe abwino, cognac, kuwala kwa mwezi, mowa.

M'mawu onse akumwa omwe amakhala ndi zakumwa zoledzeretsa, munthu wamkulu ndi mowa wa ethyl, ndipo mawonekedwe amomwe amamuledzera mu mowa onse sasintha. Komanso nthawi zonse chimayambitsa kuchokera kufalikira koyamba kwa mitsempha yamagazi ndi euphoria.

Matenda aimpso

Kulephera kwathunthu kogwiritsa ntchito Metformin nthawi imodzi ndi mowa ndi matenda a impso omwe amayamba chifukwa cha uchidakwa.

Koma ngakhale ndi limodzi mlingo wa odwala omwe samamwa mowa, mowa umachepetsa kugwira ntchito kwa impso, ndikupangitsa Metformin kukhalabe m'thupi, zomwe zimatha kubweretsa mavuto ambiri.

Zokhudza chiwindi michere

Mowa wa ethyl umalepheretsa kugwira ntchito kwa ma enzymes a chiwindi, zomwe zimayambitsa matenda a hypoglycemia. Ngati mankhwala a antidiabetes a Metformin alipo m'magazi akamamwa zakumwa zoledzeretsa, ndiye kuti zotsatirapo zake zimatha kukhala kuphwanya kwa hypoglycemic.

Vutoli limaphatikizidwa ndi kusazindikira, zomwe zimakhala zosavuta kuti ena asokonezeke ndi kuledzera. Munthu adzagona mosamala, pamene mukufunika kuchitapo kanthu mwachangu komanso mwachangu - kuyimbira ambulansi.

Ngati munthuyo akudziwa, ndiye kuti mutha kuyesa kumupatsa tiyi wokoma, mupatseni maswiti kuti muchepetse kuperewera kwa vuto la hypoglycemic.

Zotheka

Zotsatira za munthawi yomweyo makina a Metformin kapena mawonekedwe ake ndi mowa akhoza kukhala lactic acidosis.

Maonekedwe a mkhalidwe woopsa uwu akuwonetsedwa ndi zisonyezo:

• kutsika kwakukulu kwa kuthamanga kwa magazi,
• chisokonezo, kufooka,
• kunyalanyaza ena, kusayanjana ndi chithandizo, kusafuna kuyankhula, kuyankha mafunso,
• osapumira, kupumira mwachangu, Hyperventilation.

Zotsatira zowopsa za kutenga Metformin ndi mowa zimatha kukhala chodabwitsa cha Hyperventilation, limodzi ndi kuchepa kwa kuchuluka kwa mpweya m'magazi.

Kuchuluka kwa mpweya woipa kumalepheretsa kuperekanso kwa okosijeni ku minofu, chifukwa hemoglobin imamangirira ku oksijeni, koma osasunthira minofu. Zotsatira zake, minofu imavutika ndi kusowa kwa mpweya.

Malamulo Ovomerezeka

Mukamwa mowa, Metformin sangatengedwe kale kuposa masiku awiri pambuyo pake. Ino ndi yofunika kubwezeretsa ntchito ya impso. Mowa suyenera kuwonedwa osati zakumwa zoledzeretsa zokha, komanso mankhwala okhala ndi zakumwa zoledzeretsa.

Simungathe kutenga Metformin kale kuposa masiku awiri mutagwiritsa ntchito tincture wa mowa uliwonse, madzi omwe ali ndi ethyl mowa.

Mwa achinyamata, mutatha kumwa Metformin, ayenera kudutsa maola 18 asanamwe mowa. Kwa okalamba, theka la moyo wa mankhwalawo silinakhazikitsidwe. Mawu akuti kuchotsedwa kwa mankhwala amawonjezereka m'matenda a impso ndi chiwindi m'njira yosayembekezereka.

Popeza Metformin amatumizidwa kumwa katatu patsiku, palibe mwayi woti mungamwe mowa mukamalandira mankhwalawa kapena mankhwala ake anthawi iliyonse, ngati simusokoneza chithandizo.

Malingaliro a madotolo pakugwiritsa ntchito mowa komanso Metformin ndi osatsutsika - simungathe kuphatikiza mankhwala ndi chakumwa chachikulu. Pali kusagwirizana pakuwunika kwa makasitomala.

Izi zikufotokozedwa ndikuti mankhwalawa okhala ndi metformin ngati chinthu chogwiritsidwa ntchito amagwiritsidwa ntchito pakuchepetsa thupi ndi achinyamata omwe ali ndi impso wathanzi, omwe amapanga masewera olimbitsa thupi, olimbitsa thupi. M'mawunikidwe awo, pali malingaliro olakwika pa kuthekera kwa kuphatikiza mowa ndi Metformin.

Odwala omwe ali ndi matenda ashuga omwe amamwa mankhwala kuti awongolere shuga lamwazi, ndemanga zake ndi zofanana: simungathe kuphatikiza chithandizo cha Metformin ndi mowa.

Ngati pali chikondwerero chomwe mumayenera kumwa mowa, pafupifupi maola 18 ayenera kudutsa mutamwa mankhwalawo.Kuyambiranso mankhwala a Metformin, mudzapuma pang'onopang'ono pomwa mankhwalawa - mukamwa mowa, mutha kumwa mankhwalawa pakatha masiku awiri.

Kuphatikiza kwa Metformin ndi mowa kumapha!

Ndani amatchedwa chidakhwa? Munthu yemwe nthawi zonse amamwa mowa. Kodi uchidakwa ndi chiani? Monga kusuta kwa mankhwala osokoneza bongo ndi fodya, matendawo ndi mtundu wa mankhwala osokoneza bongo. Kuphatikizidwa kwa ethanol ndi mitundu ina ya mankhwala kumatha kukhala ndizotsatira zoyipa kwambiri.

Kusagwirizana kwa mankhwala a Metformin ndi mowa kwatsimikiziridwa pakufufuza.

Chifukwa chiyani zakumwa zoledzeretsa zimapha?

Kuledzera kwa zakumwa zoledzeretsa kumayambitsa chizolowezi chathupi komanso m'maganizo. Ngakhale vodika wabwino kwambiri amakhala ndi Mowa. Zimasokoneza ntchito ya ziwalo zonse zamkati. Kodi chimachitika ndi chiani mthupi la munthu motsogozedwa ndi chinthu ichi?

1. Mosiyana ndi chakudya, ethanol sikufunika kukonzedwa ndi madzi a m'mimba. Imayamba kuyamwa nthawi yomweyo, ngakhale mkati mwamlomo, kenako m'mimba ndi matumbo aang'ono. Pambuyo mphindi zochepa, imalowa m'magazi. Gawo la ethanol m'thupi limakhazikika ndi enzyme dehydrodenase. Komabe, mulondayi satha kuthana ndi milingo yayikulu ya ethanol.
2. Ubongo ndi woyamba kuvutika. Munthu woledzera amayamba kukumbukira kuiwala, kuda nkhawa, kuyerekezera zinthu zina, ndi mavuto ena amisala. Pambuyo pazaka 5 (azimayi - pambuyo pa 3), woledzera amatha kuledzera. Matendawa amawonekera mu kuwonongeka kokhazikika mu malo ndi nthawi, ziwalo zamtundu, zosagwiritsidwa ntchito zamagalimoto. Kupitiliza kumwa, woledzerayo akhoza kugwa ndipo osatuluka.
3. Kumenyanso kotsatira kumabweretsa chiwindi. Kutengera ndi "zomwe zidachitika" zakumwa zoledzeretsa, munthu amene amamwa mowa amatha kuchepa mphamvu, kuledzera kwa chiwindi kapena matenda ena a chiwindi. Matenda awiri omalizira posakhalitsa amabweretsa imfa.

Ziwalo zina zonse zimadwala mowa. Wokonda mowa amadzuka, chiopsezo cha kugwidwa ndi matenda a mtima kapena matenda a mtima chikuwonjezeka.

Mapapu ali pachiwopsezo chotenga matenda, zilonda kapena necrotic gastritis zimachitika m'mimba, zomwe zimayambitsa khansa. Chikhansa chikuvutika, impso, calcium zimatsukidwa m'mafupa, kuchuluka kwa shuga m'magazi kumasintha kwambiri.

Matenda angapo awa amafooketsa thupi, amasokoneza chizolowezi chake, chomwe posakhalitsa chitha kupha.

Kumapeto kwa zaka 50 zapitazo, mayina atatu atsopano adapezeka m'gulu la Biguanides (mankhwala ochizira matenda ashuga): phenformin, buformin, metamorphine. Onsewa adamenya nkhondo bwino ndi zizindikiro za matenda ashuga, koma awiri oyamba mwachangu adatsogolera thupi kuyipitsa ndi lactic acid (lactocytosis).

Metformin yekha, yemwe lero ndi imodzi mwamankhwala otchuka kwambiri polimbana ndi matenda ashuga, ndi omwe adakhalapo kalekale. Mankhwalawa amapangidwa kuchokera ku muzu wa mbuzi ndi French lilac. Zimapangidwa m'maiko osiyanasiyana, m'makampani osiyanasiyana opanga mankhwala, chifukwa chake m'mafakitala amapezeka ndi mayina osiyanasiyana.

Zodziwika kwambiri pakati pawo ndi:

1. Siofor.
2. Metfogamm-500, 850.
3. Glformin.
4. Mtundu wamowa.

Pali mayina ena a Metformin. Nthawi zambiri (koma osati nthawi zonse) odwala amapatsidwa Siofor. Ndemanga za madotolo zikuwonetsa kuti zimakwiyitsa matumbo ochepa kuposa ena. Siofor ndiotsika mtengo kuposa mitundu ina ya Metformin.

Mankhwala onse ali ndi mawonekedwe ofanana, ndipo amatha kusiyanasiyana pamlingo woyeretsa mankhwala ndi zinthu zothandizira zomwe zimapanga mapiritsi. Komabe, mutha kumwa zilizonse mwa mankhwalawa pokhapokha mukaonana ndi dokotala. Chithandizo chosalamulirika chingayambitse kutsika kwa shuga, chikomokere, kapena kufa.

Lactic acidosis - chowopsa m'thupi

Metformin ndi mankhwala ovuta.Nthawi zina munthawi ya mankhwala ndi mankhwalawa, kagayidwe kamasokonezedwa. Makamaka mankhwala owopsa a akumwa. Metformin ndi mowa sizingaphatikizidwe mwachindunji; zotsatira zake zidzakhala zowopsa.

Chowonadi ndi chakuti zovuta za metabolic, zomwe zimapezeka kale mu zidakwa, zimatha kupangitsa kuti thupi lipange kwambiri lactic acid.

Kwa iwo omwe ali ndi vuto la kuledzera kapena matenda ashuga, chifukwa cha lactic acidosis imatha kukhala methanol, kuthamanga magazi, chiwindi, impso kapena mtima, kusokonezeka m'mapapo.

Kodi lactic acidosis imawoneka bwanji?

1. Wodwalayo amayamba kunyansidwa kwambiri, kukhathamiritsa, kusanza.
2. Kupanda chidwi, kufooka kumayamba.
3. Pali ululu m'misempha ndi kumbuyo kwa sternum.
4. Mpweya umakuwa kwambiri, kwambiri.
5. Munthu amagwa mu nthawi yakugwa. Izi zikutanthauza kuti kupsinjika kwake kumatsika kwambiri, nkhope yake imakuthwa, khungu lake limakhala lotuwa kwambiri, ndipo manja ndi mapazi ake “amaundana”. Izi zikusonyeza kuti wodwalayo ali ndi vuto la mtima lamatenda, ziwalo sizimaperekedwa mokwanira ndi magazi. Pocheperako zimazungulira mthupi, kukulitsa mkhalidwe wa wodwalayo. Zotsatira zake, kulephera kwamtima kwambiri, hypoxia ya ubongo ikhoza kuyamba. Wodwalayo amatha kuzindikira komanso kufa.

Panthawi imeneyi, wodwala amafunika chithandizo cham'mbuyomu komanso champhamvu.

Amakhulupirira kuti ngati mungagawe nthawi yomwe mukumwa Metformin ndi mowa, ndiye kuti kuchuluka kwamamwa ochepa sikungavulaze thupi. Tiyeni tiwone ngati izi zili choncho.

Kodi mowa ndi metformin zimamwa bwanji m'thupi?

Metformin imatengedwa kuchokera m'mimba. Zochita zake zimatenga maola 2-7. Ichi ndichifukwa chake mankhwalawa amakakamizidwa kumwa katatu patsiku.

Mowa umalowa m'magazi pafupifupi nthawi yomweyo. Mukakumana ndi Metformin, lactic acid imayamba kupanga thupi, lactic acidosis imayamba. Izi zikutanthauza kuti mutha kumwa mankhwalawa maola 6-7 mutatha kumwa mankhwalawo.

Koma ... mowa mu thupi la odwala matenda ashuga umalepheretsa ntchito za ma enzymes ena a chiwindi, omwe angayambitse hypoglycemia. Mukadzaza zakumwa za m'matendawa, amayamba kuyamwa pang'ono pang'onopang'ono. Chifukwa chake, maola 6 sangakhale okwanira kuletsa "kusakanikirana" kwa Metformin ndi mowa.

Popewa kukula kwa lactic acidosis, musaphonya kamodzi, koma awiri Mlingo wa mankhwalawa.

Koma odwala matenda ashuga sangathe izi: kuchulukitsa komwe kumachitika popanda mankhwala kungayambitsenso kukomoka komanso kufa. Kuchokera pazokambirana zazitali chonchi, kumatha mfundo imodzi yokha. Metformin ndi mowa sizigwirizana. Ngakhale kumwa kwamankhwala ochepa kumatha kudzetsa munthu yemwe akupatsidwa chithandizo cha Metformin.

Zotsatira zoyipa zomwe zingayambitse mankhwala

Metformin, pamodzi ndi mankhwala ena, ali ndi mndandanda wazotsatira zoyipa zambiri. Kutenga mankhwalawa m'masiku oyambira, muyenera kulabadira momwe thupi lanu limakhalira. Izi ndizofunikira kuti musaphonye mawonekedwe a zizindikiro zowopsa, ngati zichitika.

Ngati mungawonetse zizindikiro monga:

• mawonekedwe a mseru kapena kusanza,
• Kununkhira kwazitsulo kunabuka mkamwa mwanga,
• kuchepa kapena kusowa kwa chakudya,
• kupweteka kunawoneka m'mimba mwanga
• mawonekedwe a totupa pakhungu,
• mawonetseredwe a zizindikiro zosonyeza kukula kwa lactic acidosis.

Monga lamulo, zizindikiro zonse zimazimiririka popanda kutsata patadutsa masiku ochepa kuti amwe mankhwalawo pafupipafupi; Zizindikiro zotere sizikhala pachiwopsezo chodwala.

Ngati mukukayika, muyenera kuchepetsa mlingo kapena kusiya kumwa mankhwalawo. Kuphatikiza apo, ndikofunikira kufunsa katswiri wowachiritsa kuti awalangize ndikupereka thandizo ngati kuli kofunikira.

Chimodzi mwazotsatira zoyipa ndikukula kwa lactic acidosis.Poterepa, kuchuluka kwa asidi wa lactic mthupi la munthu kumawonjezeka chifukwa cha kusokonezeka kwa metabolic.

Zizindikiro zomwe lactic acidosis yayamba ndi:

• nseru
• kusanza
• mawonekedwe a ululu pamimba
• kutsegula m'mimba
• kufooka
• kupuma kwambiri, pomwe kumangokhala kwapang'onopang'ono ndipo nthawi zina kumafika pakutha kwa chikumbumtima.

Ngati zizindikiro zoterezi zikuwoneka - muyenera kuyimbira foni dokotala!

Zomwe zimagwiritsidwa ntchito

Metformin ndimagulu ochepetsa shuga a gulu la Biguanides. Gwiritsani ntchito ngati kuli koyenera kuchiritsa odwala matenda a shuga a mtundu wachiwiri. Nthawi zambiri, amauza anthu omwe ali ndi kunenepa kwambiri, koma impso imagwira ntchito nthawi zonse.

Anayamba kuzigwiritsa ntchito m'zaka za 50 za zana la makumi awiri limodzi ndi phenformin ndi buformin. Koma izi zothandizira zimakonda kukhala chifukwa chodzikundikira m'thupi la lactic acid wambiri ndikuwoneka lactic acidosis. Ndi kukula kwa matenda awa, umunthu umafika 90%. Mukamagwiritsa ntchito mankhwalawa, mwayi wa lactic acidosis ndi wocheperako.

Koma ndizosatheka kupatula mawonekedwe a lactic acidosis pamene mukumwa ntchito iyi. Itha kuyamba ndi mankhwala osokoneza bongo kapena kuperekedwa kwa anthu omwe ali ndi contraindication.

Mutha kupeza mankhwala ogulitsa pansi pa mayina awa:

Komanso, opanga amatulutsa mankhwala ophatikiza, chimodzi mwazinthu zomwe zimagwiritsidwa ntchito ndi zomwe mankhwalawa ali.

Mowa kwa odwala matenda ashuga

Kuti mudziwe ngati zingatheke kumwa mapiritsi okhala ndi metformin ndi mowa, muyenera kumvetsetsa momwe zakumwa zoledzera zimakhudzira thupi. Mankhwala okhala ndi zakumwa akagwiritsidwa ntchito, katulutsidwe ka glycogen ku chiwindi amatsekedwa, ndipo kuchuluka kwa insulin kumakwera. Zotsatira zake, pamakhala chiwopsezo cha kukhala ndi hypoglycemia.

Kuphatikiza apo, zakumwa zoterezi zimawononga ma membala am'maselo, motero glucose omwe amalowa m'thupi amalowa momasuka m'maselo amenewa. Izi zikutanthauza kuti magazi a shuga amachepa. Ndi njirayi, pamakhala kusamva kosatha kwamanjala: ngakhale ndi chakudya chochuluka, wodwala matenda ashuga sangakwanitse kumva bwino.

Mukamamwa mowa, ndikofunikira kuti ma carbohydrate azilowa mthupi pang'ono. Potere, chitukuko cha hypoglycemia chitha kupewedwa.

Ngakhale madokotala amati odwala matenda ashuga azikumbukira chakudyacho ndikuchepetsa kuchuluka kwa mowa. Muyenera kumvetsetsa kuti ngakhale 25 g ya vodika ndikokwanira kuti ayambe njira yochepetsera kuchuluka kwa shuga m'magazi.

Mowa wambiri umalowa m'thupi, ndipo matendawo amawonekera kwambiri.

Ngati mukufuna, mungathe kumwa kapu yamowa: chakumwa ichi chimakhala ndi mowa wocheperako komanso ma carbohydrate. Koma izi zimangogwira ntchito kwa anthu omwe safuna magawo a shuga ndi mankhwala osokoneza bongo. Ngati kuchuluka kwa glucose ndikokwera, ndiye kuti siyofunika kuchita ngoziyo.

Mowa kwa anthu odwala matenda ashuga ndi osayenera kwambiri. Koma, komabe, anthu ali ndi chidwi kuti adziwe ngati nkotheka kumwa vodika pang'ono kapena kapu ya vinyo wowuma pogwiritsa ntchito metformin. Ndizofunikira kudziwa kuti, ngakhale osagwiritsa ntchito mankhwalawa, ndizoletsedwa kuti anthu odwala matenda ashuga amwe zakumwa zoledzeretsa, vinyo wokhala ndi mipanda yolimba ndi zakumwa zina zotsekemera.

Malangizo a mankhwala omwe amapangidwa pamaziko a metformin amawonetsa kuti chiwopsezo cha lactic acidosis chimawonjezeka ndi kugwiritsidwa ntchito kwake mu milandu yomwe ikuwonetsedwa mndandanda wazotsutsana. Ndipo mikangano imaphatikizapo zakumwa zoledzeretsa komanso kukulitsa zakumwa zoledzeretsa zakumbuyo zoyambira kumbuyo zakumwa zakumwa zoledzeretsa.

Mukamamwa mowa, mwayi wokhala ndi lactic acidosis ukuwonjezeka. Chiwopsezo chimachuluka ndi kuledzera kwa pachimake. Izi ndizotheka pokhapokha pakumwa mowa pamimba yopanda kanthu. Ndiowopsa kuwamwa ngati mukumva njala kapena kutsatira zakudya zamafuta ochepa.

Malangizo ogwiritsira ntchito akuwonetsa kuti mukamalandira mankhwala, muyenera kupewa kumwa mowa. Komanso, kugwiritsa ntchito mankhwala omwe ali ndi mowa kuyenera kupewa.

Zoopsa

Ngati simukufuna kudziwa nokha zomwe lactic acidosis ili, ndiye kuti muyenera kupewa kumwa mowa.

Kupatula apo, zidatsimikiziridwa kuti ngati muyezo wochiritsira wa mankhwalawa ndi ethanol akagwiritsidwa ntchito pamlingo wa 1 g pa kilogalamu iliyonse ya kulemera kwa matenda ashuga, kuphatikiza kwa lactic acid m'magazi kumadzuka nthawi 3-13. Mwakutero, kuwonjezereka kwa asidi kumapangitsa kuti lactic acidosis ipangidwe.

Komanso, ndi mowa, mayamwidwe m'matumbo a vitamini B1 amayamba kuwonongeka. Kusowa kwake kumadziwika mwa anthu onse omwe ali ndi zidakwa. Ndiko kuchepa kwa vitaminiyu komwe ndizomwe zimapangitsa kuti pakhale mtundu wa lactate acidosis.

Tiyeneranso kukumbukira kuti kugwiritsa ntchito madzi akumwa omwe ali ndi zakumwa zoledzeretsa, hypoxia imatha kukhazikika: motere, mpweya wofunikira umasiya kulowa mu minofu ndi ubongo. Izi ndichifukwa choti mitsempha yamagazi imatsekeka ndimisempha yamagazi - microthrombi. Hypoxia ndi chimodzi mwazomwe zimayambitsa lactic acidosis.

Podziwa zoopsa, anthu amakonda chidwi ndi kuchuluka kwa mowa womwe ungamwetse pambuyo kumwa mapiritsi. Kupuma kuyenera kukhala masiku osachepera awiri. Koma poganiza kuti mankhwalawo amayenera kukhala oledzera tsiku ndi tsiku, kumwa mowa kumakhala kosatheka.

Zomwe zimafanana ndi mankhwalawa zilipo

Mankhwala apaderawa ali ndi mndandanda waukulu wofanana: Fomu, Glucofage ndi Glucofage Long, Siafor, Bagomet, Metformin-Richter, Gliformin, Metformin MV-Teva, Diaformin OD, Metfogamm.

Mankhwala a analogi, ngati Metformin, ali ndi mawonekedwe apiritsi yotulutsira, zochita pafupipafupi kapena kwanthawi yayitali.

Metformin teva

Mapiritsi amachokera ku 0,5 mpaka 1.0 magalamu a chinthu chogwira ntchito. Dokotala wothandizidwa ndi mankhwalawa amalembera mapiritsi omwe amafuna kuti azitha kugwira ntchito, kuopsa kwa matendawo kumathandiza.

Mankhwalawa ali ndi tanthauzo la hypoglycemic. Amagwiritsidwa ntchito ngati mankhwala kwa anthu odwala matenda ashuga a 2. Zimapangidwa m'mitundu iwiri - kuchitira pafupipafupi komanso kwanthawi yayitali. Amapangidwa ku Israeli.

Maganizo a odwala

Iwo omwe adatha kupulumuka pambuyo pa lactic acidosis sangakhale pachiwopsezo chofuna kumwa mowa ndi mankhwala ochepetsa shuga nthawi yomweyo. Anthu odwala matenda ashuga ayenera kudziwa momwe angazindikire lactic acidosis.

Mkhalidwe uwu umadziwika ndi kupezeka kwa ululu waukulu m'matumbo, mawonekedwe osokoneza, kukula kwa kufooka. Vutolo likamakula, kusanza komanso kupweteka kwam'mimba kumawonekera.

Kenako munthuyo amagwa ndipo amatha kufa.

Madokotala mogwirizana amagwirizana za kusagwirizana kwa mowa ndi metformin. Koma kuwunika kwa odwala matenda ashuga kumatsimikizira kuti si aliyense amene amamvera uphungu wa madokotala. Zowona, ambiri sakhala pachiwopsezo chophatikiza kumwa mapiritsi ndi zakumwa zoledzeretsa limodzi. Ambiri amatenga masiku angapo ali ndi chithandizo cha tchuthi chisanafike.

Palibe chifukwa choyipa chodumpha ngati matenda a shuga amatha kuwongoleredwa. Pankhaniyi, ndikofunikira kuyang'anira nthawi zonse zinthu. Koma pokonzekera tchuthi chanu, muyenera kukumbukira kuti mutha kumwa vinyo wowuma kapena magalasi angapo a vodika. Kumwa mowa wambiri ndi zoletsedwa.

Kodi imagwirizana bwanji ndi mankhwala ena?

Mukamamwa mankhwalawa, sibwino kugwiritsa ntchito danazol, chifukwa zingayambitse vuto la hyperglycemic. Ngati kugwiritsa ntchito danazol sikupewedwa, ndikofunikira kusintha kuchuluka kwa Metformin ndikuwonetsetsa kuti ayendetsere ayodini kudziwa kuchuluka kwa glycemia.

Mosamala kwambiri, amafunika kumwa mankhwalawa ndi chlorpromazine, amathandizira kuchepetsa kupanga insulin ndikuwonjezera glycemia.

Munthawi ya kumwa ma antipsychotic ndipo mutatha kuyimitsidwa, ndikofunikira kuti mulingo woyenera wa Metformin uwongoleredwe ndikuwonetsetsa kuti glycemic ikuyang'aniridwa.

Mankhwalawa akagwiritsidwa ntchito limodzi ndi HSCs, zotupa za nicotinic acid, kulera kwapakamwa, zotengera za phenothiazine, epinephrine, diuretics, sympathomimetics, mahomoni a chithokomiro ndi glucogon, kuchepa kwa zotsatira za hypoglycemic kumachitika.

Cimetidine amathandizira kuchepetsera kuchotsedwa kwa mankhwalawa, izi zimatha kuyambitsa matenda monga lactic acidosis.

Metformin imachepetsa mphamvu ya ma anticoagulants.

Metformin ndi Mowa - Kugwirizana ndi Zotsatira

Metformin ndi mowa sizingaphatikizidwe! Kuphatikiza uku kumayambitsa kukula kwa lactic acidosis.

Matendawa amakula chifukwa chosowa vitamini B1. Ndipo mukamamwa zinthu zokhala ndi zakumwa zoledzeretsa, mayamwidwe a vitaminiyu amawonongeka malinga ndi matumbo. Mwa anthu omwe ali ndi vuto lauchidakwa, vuto lotere limasowa m'thupi.

Ndi lactic acidosis, kupuma kumakhala pafupipafupi komanso mopitilira muyeso, munthu amayamba kuona kuti alibe chidwi ndi zomwe zikuchitika pomuzungulira, chidwi chofuna kulumikizana, kusowa kwenikweni kwa chithandizo, kufooka, kusokonezeka kumachitika, kutsika kwakukulu kwa kuthamanga kwa magazi.

Nthawi yomweyo, kutenga Metformin ndi mowa kumatsutsana kwambiri mwa anthu omwe ali ndi vuto la impso, omwe amayamba chifukwa cha uchidakwa.

Mwa anthu omwe samadwala zakumwa zoledzeretsa, amamwa kamodzi limodzi ndi mankhwalawa omwe tikulingalira, ntchito ya impso imachepa ndipo mankhwalawa amachotsedwa m'thupi, ndipo izi zingayambitse vuto lakumwa ndikupangitsa kukulitsa zotsatira zoyipa zaumoyo.

Kukhalapo kwa ethyl mowa kumachepetsa kugwira ntchito kwa hepatic michere ndikuyambitsa hypoglycemia. Zotsatira zakumwa zoledzeretsa ndi Matformin zimatha kukhala kukhazikika kwa hypoglycemic coma. Pofuna kuti muchepetse kufinya, munthu ayenera kumamwa mowa wamphamvu komanso wokoma tiyi kapena maswiti.

Hyperventilation ndi chimodzi mwazotsatira zoyipa zomwe zimachitika chifukwa chogwiritsa ntchito Metformin ndi mowa. Poterepa, pali kuchepa kwamkati mwa kaboni dayokisi m'magazi.

Kuchuluka kwa mpweya wochepa m'magazi kumapangitsa kuti zikhale zovuta kuperekanso mpweya m'thupi la munthu chifukwa hemoglobin silingapatse mpweya m'maselo a minyewa. Zowonongeka ndi kuchepa kwa mpweya.

Funso lotsimikizika limabuka: Metformin ndi mowa, mutatha kumwa zochuluka motani? Yankho lake ndi losavuta: nthawi yomwe munthu atamwa Metformin ndi mowa uyenera kukhala wopitilira maola 18, koma mukamwa, mankhwalawo amayenera kutayambitsidwanso pasanathe masiku awiri pambuyo pake.

Pamafunika nthawi yochulukirapo kuti impso ziyambirenso ntchito. Kuchepetsa kumeneku kumagwira ntchito pakumwa zakumwa zilizonse za mankhwalawa ndi madzi am'madzi, omwe amakhala ndi mowa wa ethyl.

Malamulo Ovomerezeka

Musanayambe kugwiritsa ntchito mankhwalawa mukufunsidwa, muyenera kumvetsetsa kuti tanthauzo lake silikhala loti atenthe mafuta. Zimathandizira thupi, kuyang'anira njira zolondola zamagulu ndi zakudya, kugwiritsa ntchito mafuta omwe amasungidwa.

Pachifukwa ichi, mukamamwa mankhwalawa, muyenera kupewa kudya zakudya zina:

• chilichonse chomwe chimakhala ndi shuga - komanso ma lollipops a zilonda zapakhosi ndi kutsokomola, zipatso zouma, maswiti, nthochi
• mpunga woyera, pasitala, mbewu monga chimanga, mbatata
• ndikofunikira kuchita masewera olimbitsa thupi, ngati izi sizinachitike, kuchuluka kwa chakudya komwe kumamwetsa masana sikuyenera kupitirira zopitilira 1200.

Zitha kukhala zothandiza mukamagwiritsa ntchito mankhwala othandizira kuwonjezera zitsamba za mpunga, mpunga, mphodza, nyama ndi masamba aliwonse, kupatula beets ndi kaloti, pakudya. Gwiritsani ntchito mchere ndi kuwerengera zopatsa mphamvu;

Nthawi zambiri, mankhwalawa amatengedwa kawiri patsiku - m'mawa komanso madzulo asanadye, mamiligalamu 500, nthawi zina mlingo umawonjezeredwa ndikuwonjezera piritsi limodzi pamawonekedwe a m'mawa. Simungathe kumwa mankhwalawa kwa masiku opitilira 22.

Njira yatsopano ya mankhwala itha kuchitika masiku makumi atatu. Panthawi yochepetsa thupi, pamafunika kuchita masewera mwatsatanetsatane, omwe angathandize kuthamangitsa mphamvu ya mankhwalawa.

Mpaka pano, madokotala sanathe kubwera ndi lingaliro losagwirizana: mankhwalawa ndi owopsa kapena opindulitsa ngati agwiritsidwa ntchito kulimbana ndi kilogalamu yowonjezera. Ambiri amawona kuti ndi othandiza ndipo nthawi zambiri amawalembera kuti azolowere kulemera kwa anthu athanzi.

Ena, komabe, ali ndi malingaliro akuti chida ichi chimatha kuvulaza thupi lonse. Kafukufuku watsimikizira kuti kugwiritsa ntchito Metformin pofuna kuthana ndi mapaundi owonjezera kapena ayi, akuyenera kusankha ndi adokotala. Chisankho chimapangidwa payokha pachilichonse.

Mulimonse momwe zingakhalire, zili ndi inu kugwiritsa ntchito mankhwalawa pofuna kuchepetsa thupi kapena ayi. Mutapanga chisankho chotere, onetsetsani kuti mukuonana ndi dokotala!

Zambiri zosangalatsa za mankhwalawa - mu kanema:

Kodi metformin ndi chiyani?

Mankhwalawa amapangidwa mwanjira yokhala ndi miyala yaying'ono yoyera, yokutidwa ndi chipolopolo. Zikugulitsidwa zidutswa makumi atatu mu zikwama wamba. Metformin imagwiritsidwa ntchito ngati chinthu chogwira ntchito, ndipo kuwonjezera pa icho, talc, magnesium stearate, crospovidone ndi wowuma wa chimanga zilipo. Chipolopolochi, chimaphatikizapo titanium dioxide, macrogol ndi methacosterone acid. Mlingo amasankhidwa yekha ndi dokotala, kutengera momwe wodwalayo alili. Potere, chiwerengero chovomerezeka cha tsiku ndi tsiku sichingadutse mapiritsi 6. Tiyenera kunena kuti chidacho chitha kugulidwa kokha ndi mankhwala.

Metformin ndi mankhwala otchuka kwambiri, chifukwa amathandizira kuchepetsa kudalira insulin, kusintha mafuta m'thupi, komanso kuthamangitsanso kuchotsa kwa shuga wambiri, yemwe amadzaza mthupi la wodwalayo. Monga mukudziwa, anthu odwala matenda ashuga nthawi zambiri amadwala mapaundi owonjezera, ndipo izi zimakhudza thanzi lawo. Ndipo kugwiritsa ntchito mankhwalawa pafupipafupi, munthu amayamba kuchepa thupi pang'onopang'ono.

Ngakhale chidachi ndichothandiza kwambiri, sichidapangidwe kwa odwala onse. Ndi zoletsedwa kumwa mapiritsi pamaso pa kuphwanya kwamphamvu kwa chiwindi ndi kupuma, komanso pambuyo pa vuto la mtima. Mankhwalawa sanatchulidwire azimayi amtsogolo ndi kuyamwa, chifukwa zinthu zina zimalowa m'magazi ndipo zimatha kulowa mwana kudzera mu placenta kapena kulowa mthupi la mwana limodzi ndi mkaka. A contraindication ikhoza kukhala lactic acidosis. Vutoli limawonedwa kawirikawiri m'magulu a odwala matenda ashuga ndipo limatsatiridwa ndi kuchuluka kwa lactic acid m'magazi.

M'pofunikanso kusamala ndi zovuta zingapo zoyipa. Popeza Metformin imathandizira kwambiri kuchepetsa thupi, kumapeto kwake kungayambitse matenda a anorexia. Nthawi zambiri, mukamamwa mankhwalawa odwala, kuphwanya kwa chopondapo kumayang'aniridwa, komwe kumayendetsedwa ndi kuwonjezeka kwanyumba. Kuphatikiza apo, kusanza kumatha kuchitika.Ziyenera kunenedwa kuti mankhwalawa amasokoneza kuyamwa kwa thupi kwa vitamini B12 ndipo nthawi zambiri amakhumudwitsa kuperewera kwa kagayidwe kachakudya.

Kodi ndizovomerezeka kuphatikiza mowa ndi metformin?

Mankhwala ali oletsedwa kugwiritsidwa ntchito limodzi ndi zakumwa zoledzeretsa. Chiwopsezo cha lactic acidosis mwa odwala ndi chochepa kwambiri, koma ngati mumamwa moledzera ngakhale kumwa pang'ono, ndiye kuti amachulukitsa kangapo. Ndipo mkhalidwe uwu ndi wowopsa kwambiri osati kwa ziwalo zazikulu ndi machitidwe, komanso moyo.

Zonse zitha kufotokozedwa ndikuti ethanol, mutalowa m'magazi, imaphwanya kwenikweni vitamini B1, ndipo izi zimabweretsa kufooka kwakukulu. Komanso, mpweya wokwanira sukulowa m'maselo aubongo, ndipo izi zimadzetsa kukula kwa hypoxia.

Chifukwa chake, titha kunena kuti mowa sugwirizana kwathunthu ndi Metformin. Izi zikufotokozedwa momveka bwino mu malangizo a mankhwalawo.

Metformin ndi mowa: zotsatira zowopsa

Metformin ndi mowa wotengedwa: Kodi chiwopsezo cha kuphatikiza uku ndi chiani? Zotsatira zake ndi chiyani?

Metformin ndi mankhwala omwe amapangidwa kuti azichiritsa matenda a shuga. Nthawi zambiri amalimbikitsidwa kwa anthu omwe ali ndi matendawa ndipo amakonda kunenepa kwambiri. Mankhwalawa sangatengedwe ndi mowa, chifukwa izi sizingangochepetsa chithandizo cha matenda kukhala zero, komanso zimayambitsa zotsatirapo zingapo zoyipa.

Matumbo oyenda

Mothandizidwa ndi poizoni, kapamba ndi mucous m'mimba zimayatsidwa, komanso m'mimba. Zotsatira zake, nseru, kusanza, kupweteka mutu kwambiri kumachitika. Munthu amathanso kumva kuwira osakhala chakudya, kutsekula m'mimba, kudzimbidwa, ndi zina zambiri.

Palinso kuthekera kwa kupweteka kwambiri, kudula kapena kuwawa m'mimba. Ngati zizindikirozi zikuchitika, muyenera kusiya kumwa onse mowa ndi Metformin ndikufunsira kuchipatala.

Mavuto ndi magwiridwe antchito amanjenje

Izi zikuwonetsedwa ndikuphwanya mgwirizano wa kayendedwe ka anthu, kukula kwa maresi kapena ziwalo zamiyendo, kunjenjemera kwa mikono, miyendo, khosi. Munthu yemwe wagwiritsa ntchito metformin ndi mowa amatha kulankhula molakwika. Zolankhula zake sizimamveka kwa ena, koma samazindikira.

Kusokonekera mu magwiridwe antchito amanjenje kumasonyezedwanso ndi kunjenjemera kwa thupi, ma tics, ndi minyewa yodzipereka pakhungu. Migraines, kuyerekezera zinthu m'mimba, kupweteka kumbuyo, khosi, kumtunda ndi kutsika, kusokonezeka kwa kugona, kugwidwa, khunyu, zina.

Pankhaniyi, kuthandiza munthu kunyumba ndizovuta kwambiri, chifukwa chake muyenera kuyitanitsa dokotala.

Matenda a mtima

Choyambirira chomwe chingachitike ngati mungamwe metformin ndi mowa nthawi yomweyo ndikuwonjezera kuthamanga kwa magazi komanso kupumira mphamvu. Komanso, munthu amatha kutuluka thukuta kwambiri.

Kuphwanya matenda a mtima kumasonyezedwa ndi kukoka mosiyanasiyana, chizungulire, kusazindikira, ena arrhythmias.

Ngati simuleka kumwa mowa ndi mankhwala osokoneza bongo, zovuta zotsatirazi zimatha - matenda a mtima, vuto la mtima, myocardiopathy, ndi zina zambiri.

Mothandizidwa ndi poizoni, chitetezo chathupi chimadwalanso. Anthu odwala matenda ashuga omwe akalandira chithandizo ndikumamwa metformin limodzi ndi mowa amawonekera pangozi matupi awo chifukwa cha ma virus, mabakiteriya, matenda, zina.

Zakumwa zoledzeretsa ndi metformin m'thupi la munthu

Mlingo umodzi wa mankhwalawa amakhalabe m'thupi la munthu kwa maola 7-8. Chifukwa cha izi, mapiritsi a metformin amalembedwa kuti amwe katatu pa tsiku.

Ndiye kuti, mankhwalawa amapezeka mthupi lonse nthawi yamankhwala. Ethanol, kulowa m'magazi, nthawi yomweyo amakumana ndi mankhwalawa, ndikupangitsa kupanga lactic acid.

Zotsatira zake, lactocytosis pang'onopang'ono imayamba kukulira. Zizindikiro zamatenda:

• Nusea, kuda fungo. Munthu amathanso kukhala ndi vuto losakira mkamwa mwake. Nthawi zambiri, kunyansidwa mu lactic acidosis kumayendera limodzi ndi kusanza, komwe kumakhala kovuta kuyimitsa kwa maola angapo. Zikatero, munthuyo amayamba kufooka ndipo amayamba kukomoka.
• Chisoni. Momwe mtima wamunthu umazimiridwira, sangafune kulankhula kapena kumvetsera. Wodwala alibe chidwi ndi dziko lomwe limazungulira, amakhala ndi zosokoneza. Zimamuvuta kuti azingoyang'ana pa mutu uliwonse ndipo alibe chidwi chochita izi.
• Ululu m'mafupa ndi minofu. Mizeremu ikhoza kuchitika. Ndizovuta kuti munthu asamangoyenda mozungulira, komanso kuti azingokhala ndikunama. Amatha kudandaula kuti sakumvanso miyendo. Kupweteka kupweteka mu sternum kumachitikanso.
• Kupuma movutikira. Mwamuna amadandaula chifukwa chosowa mpweya. Zimamuvuta kuti atulutse / kutulutsa, pomwe akumva kupweteka kwambiri. Mukapumira, kugwedeza kapena phokoso kumachitika.
• Kuthyola nkhope ndi miyendo. Matenda a magazi a munthu amatsika kwambiri, mikono ndi miyendo yake imayamba kuzizira komanso thukuta. Pali mwayi kuti wodwalayo amasiya kuzindikira.

Zakumwa zoledzeretsa zimatha kumwa pokhapokha ngati metformin itachoka kwathunthu kwa thupi, ndiye kuti, maola 10-12 mutatha kumwa mankhwala omaliza. Kusagwirizana kwa mankhwalawa ndi ethanol kwatsimikiziridwa ndi maphunziro a sayansi. Kumwa metformin ndi mowa sikulimbikitsidwa, chifukwa izi zimatha kuyambitsa zovuta zingapo, kuphatikizapo chikomokere ndi kufa.

Metformin ndi mowa wamagulu a shuga ndi polycystic

Mankhwalawa amalembedwa osati kwa odwala matenda ashuga okha, komanso kwa anthu omwe ali ndi vuto la kubereka. Metformin imathandizira kuchotsa matenda ambiri, kuphatikizapo kubereka kwa akazi.

Zakumwa zoledzeretsa zomwe zimakhala ndi matenda a shuga, komanso matenda a polycystic, sizovomerezeka. Kunyalanyaza malingaliro a akatswiri, ndizotheka kukwaniritsa zotsatira monga zovuta za matenda omwe alipo, komanso kukula kwa matenda atsopano, kuphatikizapo khansa ya chithokomiro komanso zotupa zina.

Anthu omwe ali ndi vuto la zakumwa zoledzeretsa ayenera kufunafuna thandizo ku chipatala kapena m'malo othandizira odwala. Pamenepo angathe kulandira chithandizo choyenera chamankhwala.

Kuvulaza kwa mowa ku matenda ashuga ndi matenda ena

Chovomerezeka kumwa mowa mwa anthu omwe ali ndi thanzi labwino komanso Mlingo wambiri. Mowa umasokoneza thupi. Kuledzera kumawopseza zotsatirazi:

1. Mavuto a metabolism. Anthu odwala matenda ashuga amakonda kwambiri kunenepa; mowa ungakuthandizeni kukhala bwino. Mowa wa Ethyl umakhudza metabolism, potero umaletsa kuchotsedwa kwa poizoni ndi zotayidwa m'thupi.
2. Matenda a mtima. Anthu odwala matenda ashuga, kumwa mowa, ali pachiwopsezo chotenga mitsempha ya varicose, stroke, vuto la mtima, matenda ena ambiri, chithandizo chomwe chimafuna nthawi yayikulu, ndalama ndi kulimbikira. Anthu omwe amadalira insulin akamamwa, amaika moyo wawo pachiwopsezo.
3. Mavuto obala. Malinga ndi ziwerengero za odwala matenda ashuga, amakhala ndi mavuto okhala ndi mwana. Mowa umatha kuyambitsa zinthu.
4. Mavuto ndi magwiridwe antchito amanjenje. Nthawi zambiri mwa anthu omwe ali ndi matenda ashuga, komanso omwe amamwa mowa, mavuto am'maganizo awa amawonekera:
   • kuyereketsa zinthu (zowoneka, zomvera, zolimbitsa thupi),
   • zamkhutu
   • wokondweretsa popanda chifukwa
   • kusowa tulo
   • nkhalwe
   • kupanda chidwi, kukhumudwa, etc.

Zoyenera kuchita kuti muchepetse chidwi ndi mowa

Zimakhala zovuta kwa munthu amene amadalira mowa kuti asiye chizolowezi choyipa.Kuti musiye kumwa, muyenera, choyamba, chikhumbo. Wodwalayo ataganiza zosiya chizolowezi choipacho kamodzi ndikukhalanso ndi thanzi labwino, ayenera:

• Pemphani thandizo lapadera. Nthawi zina zimakhala zosatheka kusiya kumwa wekha. Madokotala azachipatala okhaokha ndi akatswiri azamankhwala omwe angathandize munthu kusiya chizolowezi choyipa ndikuyamba moyo wathanzi.
• Kuchita chilichonse kuti muiwale za mowa. Munthu ayenera kuphunzira kudya, kudya, kugwiritsa ntchito nthawi yaulere popanda zakumwa zoledzeretsa, kupita kumasewera.

Simungamwe mowa osati kokha kwa odwala omwe ali ndi matenda a shuga, koma makamaka kwa anthu onse omwe ali ndi vuto lalikulu la thanzi. Ndikofunikanso kukumbukira kuti palibe mankhwala amodzi omwe amagwirizana ndi mowa.

Metformin ndi mowa: kuyanjana ndikatha kumwa kuchuluka

Metformin ndi mankhwala othandiza kugwiritsidwa ntchito pochiza odwala matenda ashuga. Chuma chake chachikulu ndikuchepetsa kudalira kwa insulini, komanso kupewa kuti kunenepa kwambiri.

Zinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawa sizisintha kuchuluka kwa mahomoni ndi insulin m'magazi a wodwalayo, komabe, imatha kusintha njira zomwe zimakhudzira thupi lonse. Mulingo wokwanira wa mankhwala umafikiridwa pokhapokha maola 6, ndiye kuti zochita pazinthuzo zimayamba kuchepa.

Munkhaniyi tikambirana za Metformin ya mankhwala, cholinga chake, kuphwanya malamulo komanso kugwirizanitsa ndi mowa.

Kodi zogwirizana ndi metformin ndi ethanol?

Malinga ndi kunena kwa mankhwalawo, mankhwala a metformin omwe amagwiritsidwa ntchito popanga mankhwala sagwirizana kwenikweni ndi zinthu zakumwa zoledzeretsa.

Kodi mowa ndi metformin ndizotheka kuphatikiza zinthu ziwiri izi? Malinga ndi kunena kwa mankhwalawo, mankhwala a metformin omwe amagwiritsidwa ntchito popanga mankhwala sagwirizana kwenikweni ndi zinthu zakumwa zoledzeretsa. Zinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimakhala mthupi la munthu mpaka maola 7, ndipo zimatengedwa katatu patsiku.

Kumwedwa kwa magazi m'magazi kumachitika nthawi yomweyo, atatha kugwiritsa ntchito. Ndikulumikizana kwambiri ndi mowa ndi mankhwala osokoneza bongo, lactic acid imamasulidwa ndipo lactic acidosis imayamba.

Amaloledwa kumwa mowa kwa maola 7 kuchokera nthawi yomwe mumamwa Metformin, kotero kuti mupewe zovuta, ingokhala ndi mowa kapena kudumphira pamiyeso ingapo ya mankhwalawo.

Muzochita zamankhwala, pakhala pali zochitika zina zokugwera kokomoka komanso kuyambika kwa zotsatira zoyipa mukamaphatikizana ndi Metformin ndi mowa. Pofuna kupewa zoyipa, muyenera kudzipatula ngakhale mpaka mulingo wochepa wa ethanol.

Mankhwala ali ndi zovuta pa:

• kugaya chakudya, thupi litalowa m'thupi, kupanga zakumwa zoledzeretsa zimayamba, zomwe zimayambitsa kutulutsa kwa kapamba ndi mucous membrane,
• kuchepa kwa dongosolo lamanjenje, kumadziwonetsera mu malo opanda munthu, kulumikizana, kusowa kwa malo, ndi kuyerekezera zinthu zina kumatha kuchitika,
• kusokonekera kwa mtima dongosolo, kulumpha mu kuthamanga kwa magazi, kupezeka kwa arrhythmias, kutaya chikumbumtima, kuyamba kwa vuto la mtima.

Zotsatira zake ndi ziti?

Choyambirira, ziyenera kukumbukiridwa kuti ethanol imabweretsa zotsatira zoyipa kwambiri pakugwiritsa ntchito ziwalo zofunika monga impso ndi chiwindi. Potengera izi, kufa kwa njala kwa minyewa ya m'mimba ndipo ma cell amakula, zomwe zimapangitsa kuti akhale ndi vuto la hypoglycemic, ndipo ena amatha kuledzera koma osathandiza wodwalayo. Komanso, mukamamwa mowa ndi Metformin, matenda a coronary nthawi zambiri amakula, kuphwanya mgwirizano mu kayendedwe ka kayendedwe ndi kayankhulidwe.

Koma choopsa kwambiri ndi lactic acidosis, yomwe imayendetsedwa ndi kuthamanga kwa magazi, kufooka kwambiri komanso kusowa kwa chikumbumtima, kusazindikira, komanso kupuma movutikira.Kuyang'aniridwa kuyenera kulipiridwa kuti imfa ikhoza kuchitika popanda chithandizo chamankhwala. Ichi ndichifukwa chake pamaso pa matenda a shuga ndikwabwino kutsatira kadyedwe ndikupewa mowa kwathunthu.

Endocrinologists nthawi zambiri amapereka mankhwala othandizira Metformin kwa odwala awo. Awa ndi mankhwala othandiza antipyretic omwe amathandiza anthu odwala matenda ashuga kuti azisamalira matendawa. Ayenera kukhala oledzera kwa nthawi yayitali, chifukwa chake odwala matenda ashuga amakonda kusakanikirana kwa metformin ndi mowa.