Mafuta a Gentamicin > Chithandizo ndi kupewa

Antimicrobial, antibacterial bactericidal kanthu. Kugwiritsa ntchito: kuwotcha, mabala, matenda a pakhungu, ziphuphu.

Mtengo wongoyerekeza (panthawi yofalitsa nkhaniyi) kuchokera ma ruble 33.

Lero tikulankhula za mafuta a glamicin. Ndi mtundu wanji wamankhwala awa? Kodi chimathandiza ndi chiyani? Kodi imagwiritsidwa ntchito bwanji? Kodi ndingathe kuzigwiritsa ntchito pa nthawi yapakati, kuyamwa komanso ndili mwana?

Mankhwala amtundu wanji

Mankhwala othandizira oteteza khungu.

Amakhala ndi antimicrobial momwe amathandizira matenda a pakhungu. Kuphatikizidwa ndi gulu la aminoglycoside, lothandiza pakhungu pakhungu ndi ma gram-tizilombo tosaoneka bwino.

Zocheperako zimawonedwa pama gramu abwino.

Antibiotic yochizira matenda opatsirana komanso otupa. Kupezeka kwake ndi kutha kwa mankhwalawo kumatsimikiziridwa ndikuwunika koyenera.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mafuta ogwiritsira ntchito zakunja kwa 0,1%: kuchokera ku chikasu mpaka kuyera (mu chubu cha aluminium 15 g, mu katoni ka 1 tube).

Kupanga 1 g mafuta:

yogwira thunthu - mankhwalawa (mwa mankhidwe a mankhwalawa) - 0,001 g,
zopereka: mafuta olimba a parafini, mafuta oyera oyera oyera.

Kutulutsa mawonekedwe, zikuchokera, ma CD

Imafotokozedwa ngati mtundu wa kirimu 0,1% yogwiritsidwa ntchito kunja. Mitundu ina ya mankhwalawa:

Diso likugwera
yankho la kulowetsedwa kwa mtsempha,
intramuscular jakisoni yankho,
ufa pakakonzedwe ka jakisoni.

Chomwe chimagwiritsidwa ntchito popangira mafuta ndi khungu la mankhono la sodium ndi mankhwalawa 0,001 g.

Amachepetsa mapuloteni opangidwa ndi mabakiteriya, ndi mankhwala amphamvu oletsa kupha matenda osiyanasiyana.

Zinthu zothandiza: paraffin yolimba komanso yofewa.

Mankhwala

Ndi m'badwo watsopano wa aminoglycosides.

Kuwononga khoma la membrane wa bacterium kumayambitsa kufa kwake, ngakhale gawo la mitosis (gawo).

Imatha kupanga pawiri ndi tRNA ndi mRNA, kuletsa mapangidwe a bakiteriya a ribosomal.

Ma cytoplasm omwe anawonongeka, chifukwa chodziwikiratu ndi glamicin sulfate, amasiya kupanga mapuloteni a pathogen.

Yothandiza kwambiri polimbana ndi mabakiteriya opanda gramu:

nsomba
shigella
Escherichia coli,
Proteus
pseudomonium
enterobacteria.

Tizilombo toyambitsa matenda ndi aerobic bacteria.

Pokhudzana ndi gwero labwino la matenda, mafuta opaka a gramu samagwira:

matenda a staph,
matenda a streptococcal (mitundu ina).

Oyenera kukana ndi penicillin thupi, koma sangathe kuwononga khoma la cell la ma virus monga neisseria, treponema ndi anaerobes ambiri.

Pharmacokinetics

Ngati kuwonongeka kwa malo okulirapo, kumayikidwa pansi kumayamwa mwachangu kwambiri.

Kugwiritsira ntchito zonona pa minofu ya granulation kumabweretsa kuyamwa kwamankhwala mwachangu. Gentamicin ili pafupi kuti isatengere khungu loyipa.

Imapukutidwa kwathunthu kudzera mu impso.

Zisonyezero zakunja zakumwa zamafuta a glamicin zimagawidwa pazoyambira zimayambira ndikubwerera kwachiwiri kapena:

matenda oyamba a khungu: furunculosis, folliculitis yakunja, mawonekedwe owoneka ndi ziphuphu zakumaso, pyoderma (kuphatikizapo gangrenous), paronychia,
matenda opatsirana: zotupa za khungu la mafangasi, zamkati zam'mimba, dermatitis ya seborrheic, kupindika kwakukulu, mabala a varicose opatsirana,
mabala oyatsidwa
mawonekedwe abrasions,
zotupa za pakhungu
matsitsi padziko pakhungu.
Kuchepetsa kuvulala kwa khungu,
zipsera zopweteka za postoperative,
kutentha kwa digiri ya I ndi II,
Kulumwa ndi tizilombo.

Mafuta Okhazikika a Gentamicin:

Ndikotheka kuchitira mucosa wammphuno ndi matenda achiwiri a staph.

Momwe mungagwiritsire ntchito

Chochita chimagwiritsidwa ntchito mwapamwamba, kuthira wosanjikiza wowonda pachilonda chomwe chatsukidwa kale ndi mabala ndi michere ya necrotic. Kupukuta sikulimbikitsidwa.

Lemberani katatu patsiku. Zosanjazo ziyenera kukhala zoonda. Pootcha, gwiritsani ntchito mpaka katatu pamlungu ngati mawonekedwe a compress kuchokera pamalonda.

Mulingo wambiri watsiku ndi tsiku wokhala ndi mabala akulu osaposa 200 mg. Njira ya chithandizo ndi masiku 14.

Malangizo ogwiritsira ntchito

pa matenda a pakhungu (ziphuphu, ziphuphu zakumaso, ziphuphu), gwiritsani ntchito mfundo 2 kawiri pa tsiku,
zithupsa zimakutidwa ndi wokutira, kusiya mpaka kumizidwa kwathunthu,
gentamicin imagwiritsidwa ntchito pakhungu louma, chifukwa chake, ndi exudative
Makungu owonda amatsukidwa ndi yankho la chlorhexidine, furatsilina kapena hydrogen peroxide. Ma Burn sangathe kutsukidwa ndi peroxide!

Zotsatira zoyipa

Itha kukhala limodzi ndi zomwe zimachitika m'deralo. Zotsatira zoyipa zimaphatikizapo: kuyabwa, kuwotcha, hyperemia, edema.

Woopsa milandu: angioedema.

Mbali ya mapangidwe magazi - kuchuluka kwa eosinophils ndi leukocytosis.

Ngati chithandizo cha nthawi yayitali chikufika pang'onopang'ono, zotsatira za nephrotic kapena ototoxic zimayamba.

Chithandizo cha zotheka thupi lawo siligwirizana ikuchitika ndi mankhwala a antihistamines.

Contraindication

Hypersensitivity kuti aminoglycosides,
tsankho
ukalamba
ana osakwana zaka 3,
kuwonongeka kwaimpso,

Matenda a parkinsonism, myasthenia gravis, botulism, ndi kuchepa kwa mitsempha ya mitsempha amafunikira kugwiritsa ntchito mankhwala mosamala.

Pa nthawi yoyembekezera

Woletsedwa mu trimester yoyamba ya kutenga pakati. Mu II ndi III pokhapokha akutsimikiziridwa ndi dokotala.

Gentamicin sulfate imatha kukhala ndi poizoni pa mwana wosabadwayo, pamene imadutsa chotchinga cha hematoplacental.

Kuyanjana kwa mankhwala osokoneza bongo

Chithandizo cha mafuta a folicomy sayenera kutsatana ndi mankhwala opha maantibayotiki ndi streptomycin ndi florimycin. Potaziyamu, sodium, magnesium, calcium kumachepetsa ntchito ya mankhwala.

Zosagwirizana ndi heparin komanso acid wosakhazikika.

Ntchito ndi corticosteroids kumawonjezera achire zotsatira za onse mankhwala.

Mtengo wapakati wa mafuta a glamicin mu pharmacy ndi ma ruble 50-70. Alibiretu mtengo wotsika mtengo, koma kuchokera kwa okwera mtengo:

Gentamicin - Akos - ma ruble 100-120 - ali ndi chinthu chomwecho,
Malinga ndi umboni ndi njira yogwiritsira ntchito: Supirocin - ma ruble a 360-770, Baneocin - mpaka 390 ma ruble, Syntomycin - mpaka ma ruble 800,
Mankhwala okhala ndi mahomoni ophatikizika ndi gentamicin ndi Mafuta.

Osatikita

Osagwiritsa ntchito ana osakwana zaka zitatu.

Ndi zoletsedwa mu 1 trimester ya mimba komanso poyamwitsa

Zizindikiro zogwiritsidwa ntchito

matenda oyamba ndi bakiteriya a pakhungu ndi (kapena) minofu yofewa yomwe imayambitsidwa ndi microflora yovuta:: folliculitis yapamwamba, pyoderma (kuphatikizapo gangrenous), furunculosis, paronychia, sycosis, ziphuphu zopatsirana,
matenda apakhungu a pakhungu: dermatitis yomwe ili ndi kachilombo (kuphatikiza seborrheic, kulumikizana ndi chikanga), kupatsirana kwa ma bacteria pakhungu komanso zotupa pakhungu,
zotupa zapakhungu zodwala matendawa osiyanasiyana: mabala (kuphatikiza sagging, opaleshoni), mabala, kuwotcha (kwapamwamba, II - IIIA madigiri), zilonda zam'mimba (kuphatikizapo varicose), kulumwa ndi tizilombo,
zotupa pakhungu ndi cysts (mutatsegula ndi kukhetsa).

Malangizo ogwiritsira ntchito mafuta a Gentamicin 0,1%: njira ndi mlingo

Mafuta a Gentamicin 0,1% amagwiritsidwa ntchito kunja. Mankhwala umagwiritsidwa ntchito wochepa thupi wosanjikiza ndi khungu lomwe lakhudzidwa ndi khungu pambuyo pochotsa masamba a purulent ndi necrotic katatu patsiku. Ndi zotupa zikuluzikulu za khungu, mlingo woyenera wa tsiku ndi tsiku wa glamicin sayenera kupitirira 200 mg, womwe umafanana ndi 200 g yamafuta. Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala.

Bongo

Popeza mankhwalawa ali ndi mayamwidwe otsika, mankhwalawa ndi osatheka.

Panthawi yogwiritsa ntchito mafuta a Gentamicin 0,1% muyezo wokwera, komanso zotupa pakhungu, nephrotic (kuphatikizapo azotemia, proteinuria) ndi ototoxic (chizungulire, kawirikawiri, kumva kuwonongeka), kuchuluka kwa hepatic transaminases, hyperbilirubinemia, kusintha kwa ma cell a zotumphukira magazi.

Malangizo apadera

Mafuta a Gentamicin 0,1% sagwiritsidwa ntchito pakugwiritsa ntchito mucous nembanemba, kuphatikiza pamaso.

Pogwiritsa ntchito mafuta onunkhira a glamicin, kukula kwa kukana ndikotheka.

Mankhwalawa pakukonzekera mankhwalawa, tikulimbikitsidwa kuti mankhwala opha maantibayotiki azigwiritsidwa ntchito, chifukwa kugwiritsa ntchito mankhwala osokoneza bongo a mankhwalawa kungapangitse kukula kwa tizilombo toyambitsa matenda osagwirizana ndi maantibayotiki, kuphatikizapo matenda a fungus. Pankhaniyi, monga momwe pakukhumudwitsira khungu, kukhudzika kwa thupi, kapena kutenga kachilomboka, mankhwalawa ndi mafuta a mafungo ayenera kutha ndipo chithandizo choyenera chizichitika.

Mankhwala ali osavomerezeka kuti agwiritsidwe ntchito munthawi yomweyo mankhwala a aminoglycoside antibayotiki chifukwa chowonjezera chiopsezo cha zotsatira zoyipa.

Ngati 1 sabata ntchito mafuta, achire zotsatira kulibe, ndikofunikira kukaonana ndi katswiri.

Ngati mankhwalawa akhudzana ndi malo akuluakulu pakhungu, makamaka kwa nthawi yayitali, komanso ngati pakufunika kuthandizira pakhungu lowonongeka, kuyamwa kwa mankhwalawa kumatha kuchuluka. M'mikhalidwe imeneyi, makamaka kwa ana, kusamala kuyenera kuchitidwa, popeza chiwopsezo cha zotsatira zoyipa zimakula.

Mukamagwiritsa ntchito mankhwalawa mu maliseche, ndikofunikira kudziwa kuti mafuta amtundu amatha kutha kuchepa kwa mphamvu ya makondomu a latex chifukwa parafini yoyera yomwe ili mmenemo, potero amachepetsa mphamvu yakulera.

Mimba komanso kuyamwa

Mu trimester yoyamba ya mimba, mafuta a mafuta a 0.1% samalimbikitsidwa. Mu trimesters yachiwiri ndi yachitatu, kugwiritsa ntchito mafuta kumakhala kotheka pomwe phindu lomwe mayi akuyembekezeralo limapitilira chiwopsezo cha mwana wosabadwayo.

Pazinthu zochepa, gentamicin amadutsa mkaka wa m'mawere. Chifukwa cha kusamwa kwa mankhwalawa m'matumbo am'mimba, kukulira kwa zotsatira zoyipa nthawi yoyamwitsa kulibe mwayi.

Mtengo wa mafuta a Gentamicin 0,1% m'masitolo ogulitsa mankhwala

Mtengo woyeserera wa mafuta a Gentamicin a 0% ndi pafupifupi ma ruble 70 pa chubu chilichonse cha 15 g.

Maphunziro: Rostov State Medical University, apadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo ovomerezeka. Kudzipatsa nokha mankhwala kuopsa!

Malinga ndi kafukufuku, azimayi omwe amamwa magalasi angapo a mowa kapena vinyo pamlungu amakhala pachiwopsezo chotenga khansa ya m'mawere.

Anthu omwe amakonda kudya chakudya cham'mawa nthawi zambiri amakhala onenepa kwambiri.

James Harrison wazaka 74 yemwe amakhala ku Australia amakhala wopereka magazi pafupifupi nthawi 1,000. Ali ndi mtundu wamagazi osafunikira, ma antibodies omwe amathandizira akhanda omwe ali ndi vuto lalikulu la magazi kukhala ndi moyo. Chifukwa chake, waku Australia adapulumutsa ana pafupifupi mamiliyoni awiri.

Amayi ambiri amatha kusangalala mwakuganizira za thupi lawo lokongola pakalilore kuposa kugonana. Chifukwa chake, akazi, yesetsani kuyanjana.

Mabakiteriya mamiliyoni ambiri amabadwa, amoyo ndi kufa m'matumbo athu. Amatha kuwoneka pa kukula kwakukulu, koma ngati atakhala palimodzi, akhoza kukhala mu kapu ya khofi yokhazikika.

Poyamba zinkakhala kuti kumatheka kumapangitsa thupi kukhala ndi mpweya wabwino. Komabe, malingaliro awa adatsutsidwa. Asayansi atsimikizira kuti ukamadzuka, munthu amazizira ubongo ndikusintha magwiridwe ake.

Mankhwala akutsokomola "Terpincode" ndi amodzi mwa atsogoleri ogulitsa, ayi chifukwa cha mankhwala ake.

Ku UK, kuli lamulo malinga ndi momwe dokotala wothandizira amatha kukanachita opaleshoni ngati atasuta kapena wonenepa kwambiri. Munthu ayenera kusiya zizolowezi zoipa, kenako, mwina, sangafunikire opareshoni.

Mwazi wa munthu "umayenda" m'matumbo omwe akukakamizidwa kwambiri, ndipo ngati umphumphu wake waphwanyidwa, amatha kuwombera mpaka 10 metres.

Chiwindi ndi chiwalo cholemera kwambiri m'thupi lathu. Kulemera kwake pafupifupi 1.5 kg.

Pali ma syndromes osangalatsa kwambiri azachipatala, monga kuphatikiza zinthu. M'mimba mwa wodwala m'modzi wodwala mania uyu, zinthu 2500 zakunja zidapezeka.

Mankhwala ambiri poyamba anali ogulitsidwa ngati mankhwala osokoneza bongo. Mwachitsanzo, a heroin adagulitsidwa ngati mankhwala a chifuwa. Ndipo cocaine adalimbikitsidwa ndi madokotala ngati opaleshoni komanso ngati njira yowonjezerera kupirira.

Munthu amene amamwa mankhwala opondeleza nthawi zambiri amakhalanso ndi nkhawa. Ngati munthu athana ndi kukhumudwa paokha, ali ndi mwayi wonse wakuyiwalako zamtunduwu mpaka kalekale.

Madokotala a mano adapezeka posachedwa. Kalelo m'zaka za zana la 19, inali ntchito ya tsitsi wamba kuti akatulutse mano odwala.

Munthu wophunzira sakhala wokonzeka kutenga matenda aubongo. Ntchito zaluso zimathandizira kuti pakhale ziwalo zina zowonjezera kulipirira odwala.

Malinga ndi ziwerengero, pafupifupi 80% ya akazi ku Russia amadwala bakiteriya. Monga lamulo, matenda osasangalatsa awa amatsatiridwa ndi kutuluka koyera kapena imvi.

Pharmacology yamankhwala: momwe mankhwalawo amagwirira ntchito, omwe sangathe kupirira nawo?

Musanaphunzire za maantibayotiki omwe amatchedwa "Gentamicin-Akos" (momwe mafuta amapangidwira), ndikofunikira kumudziwa bwino. Mankhwala ndi chinthu chachikaso chowoneka, chomwe chimaphatikizapo zomwe zimadziwika ndi dzina lomweli. Gawo la glamicin limatchula ma aminoglycoside maantibayotiki.

Mankhwalawa amatha kukhala ndi bactericidal zotsatira ndikuchotsa tizilombo tating'onoting'ono. Mankhwalawa ali ndi mawonekedwe osiyanasiyana. Imalowa mkatikati mwa khoma la bakiteriya, kuletsa kapangidwe kake. Imawononga tizilombo tating'onoting'ono ta gramu, komanso pafupifupi gram iliyonse. Ngakhale ikugwira bwino, Gentamicin-Akos sangathe kuthetsa matenda a meningococcal, treponema ndi zina zama staphylococcus. Ma tizilombo a anaerobic nawonso amalimbana ndi mankhwalawa.

Kodi malangizo ogwiritsira ntchito akuti chiyani: zikuwonetsa ndi contraindication

Ngati mukufuna kugwiritsa ntchito mafuta a Gentamicin-Akos, malangizo omwe angagwiritsidwe ntchito angakuuzeni za kufunikira kotere. Chofotokozera chikufotokozera zomwe mankhwalawo amathandizira nawo. Mwa zina:

bakiteriya matenda akhungu
gangodous pyoderma,
furunculosis ndi zapamwamba folliculitis,
paronychia, sycosis,
seborrheic dermatitis (kachilombo),
ziphuphu
Zilonda zoyambitsidwa ndi mitsempha ya varicose.

Osagwiritsa ntchito mafuta ndi hypersensitivity kwa yogwira thunthu, neuritis yamitsempha yamagazi. Matenda akulu aimpso, uremia, mkaka wa m'mimba komanso pakati amakhalanso ndi zotsutsana.

Dermatitis ya eczematous: kugwiritsa ntchito mafuta a antibacterial

Nthawi zambiri anthu omwe amatembenukira kwa dermatologist wokhala ndi zodandaula za totupa amamva kuzindikira. Dermatitis ya eczematous ndi thupi lawo siligwirizana, lomwe limawonetsedwa ndi redness pakhungu, kunyezimira komanso mapangidwe ang'onoang'ono a vesicles. Ngati matendawa sanayambike, ndiye kuti chithandizo chamankhwala sichifunikira kugwiritsa ntchito maantibayotiki. Ma antihistamines, mafuta amafuta ochiritsa amaperekedwa kwa wodwala.

Koma zimachitikanso kuti thovu lomwe linayambika limayamba kuphulika kapena kutsegulidwa ndi munthu wodwalayo. Pankhaniyi, matenda achiwiri amachitika. Panthawi imeneyi, mankhwala "Gentamicin-Akos" ndi omwe amakhazikitsidwa.Kodi mafutawa amagwiritsidwa ntchito bwanji ngati zotere? Mankhwalawa amatha kuthetsa kachilombo komwe kamalowa. Izi zikuthandizira kuchira mwachangu. Ikani mankhwala kunja, kawiri pa tsiku. Ngati mafuta owonjezera agwiritsidwa ntchito, ndiye kuti muyenera kusiya pakati pawo.

Kodi Gentamicin-Akos angathandize ndi matenda otchedwa paronychia?

Chithandizo cha zotsekemera za periungual zambiri nthawi zambiri chimayendera limodzi ndi mankhwala a antibacterial. Zomwe zimayambitsa matendawa zimatha kukhala zosiyanasiyana: kachilombo ka virus kapena fungus, kuvulala, ma radiation, manicure osayenera, ndi zina zotero. Ngati kusamba kwayamba, komwe kumayambitsa matenda a paronychia, chithandizo chikuyenera kuyenderana ndi kugwiritsa ntchito maantibayotiki.

"Gentamicin-Akos" imagwiritsidwa ntchito kumalo opaka mawonekedwe a compress. Kukondoweza kusanachitike kungatsegulidwe. Koma ndikosatheka kudziyimira pawokha mwakufuna kwawo. Pofuna kuti musakhale woipitsitsa, muyenera kufunsa dokotala wa opaleshoni. Pambuyo pa njirayi, ikani mankhwalawo ndi wosanjikiza pa periungual roller, wogwira gawo la khungu labwino. Valani chovala chosawoneka bwino ndikuvala chala. Mapangidwe awa sangathe kunyowa. Muyenera kusintha bandeji katatu patsiku.

Ndemanga zake zomwe zidzakhale zosangalatsa kudziwa wogula

Odwala nthawi zambiri amafunsa kuti: chifukwa chiyani adokotala adalemba Gentamicin-Akos, chifukwa chiyani? Mafuta, monga momwe adakwanitsira, amatha kuthana ndi ma bacteria ambiri pakhungu. Malinga ndi ndemanga, nthawi zambiri ogula amagwiritsa ntchito mankhwalawa polimbana ndi zithupsa ngakhale ziphuphu kumaso. Ngati njira yotupa imayambitsidwa ndendende ndi mabakiteriya, ndiye mankhwalawo angakuthandizeni. Malingaliro abwino akupanga za iye. Kwa anthu ena, maantibayotiki athandiza kuchiritsa matenda obwera ndi mabakiteriya.

Koma, ngati za mankhwala ena aliwonse, pamakhala kuwunika kotsutsa komanso koyipa. Ogula ena sanakhutire ndi mankhwalawa. Iwo ati kuti mafutawa sanawathandize kokha kuthana ndi mavutowo, komanso kuwonjezera zina zambiri zosasangalatsa. Nthawi zambiri timalankhula za ziwengo. Ichi ndi chimodzi mwazotsatira za mankhwalawa. Ngati zikuchitika, muyenera kufunsa dokotala kuti akupatseni malangizo.

M'malo momaliza

Kuchokera munkhaniyi mudaphunzira zomwe mafuta a Gentamicin-Akos amathandizira kuchiritsa. Mankhwalawa ndi othandizanso kumatenda obwera chifukwa cha bakiteriya, kupatsirana, kuwotcha. Chidachi chimagwiritsidwanso ntchito pochiza matenda a bacteria acular. Ngakhale ali ndi mawonekedwe abwino komanso ogwira ntchito kwambiri pa mankhwalawa, musagwiritse ntchito molakwika.

Osagwiritsa ntchito mafuta osagwiritsa ntchito mankhwala a dokotala. Kumbukirani zotsatirapo zosasangalatsa za chithandizo chosayenera. Ngati nthendayo yayamba chifukwa cha matenda oyamba ndi fungus kapena kachilombo, ndiye kuti mankhwalawo sangakuthandizeni. Komanso, imapha zomera zachilengedwe, ndikupanga malo abwino kwambiri operekera mabakiteriya. Kuchitiridwa moyenera!

Mumada nkhawa ndi prostatitis? Sungani ulalo

Pokhudzana ndikuchulukirachulukira kwamatenda amkhungu, kusankha kwa mankhwala kumachulukirachulukira, zomwe zimapangitsa kuti pakhale zovuta zingapo. Pakati pa mankhwala othandiza kwambiri, munapezeka mankhwala ngati Gentamicin Ofuta.

Mankhwalawa adalandiridwa mwa odwala ambiri chifukwa cha mtengo wake wokwanira, wolimba mphamvu. Tiphunzira lero malangizo oti agwiritsidwe ntchito mafuta onunkhira a ana ndi akulu, maphatikizidwe ake, mtengo wake ndi malingaliro ake za izi.

Zolemba za mankhwala

Mankhwala omwe amawaganizira ndi ntchito yayitali angayambitse kukana kwa tizilombo toyambitsa matenda tizilombo toyambitsa matenda.
Ngati odwala omwe akudwala aimpso amalephera kugwiritsa ntchito mankhwala pochotsa khungu.
Mankhwalawa akhoza kulowetsedwa pang'ono m'magazi, ndikuwonetsa kuchiritsa kwake.
Ngati mutagwiritsa ntchito mankhwalawa kwa nthawi yayitali njira zochizira sizikuwoneka, ndikofunikira kusiya kugwiritsa ntchito, funsani katswiri.

Tiyeni tionenso kuphatikizidwa kwa mafuta onenepa.

Mafuta a Gentamicin kuchokera ku Actavis (chithunzi)

Chubu yamadzi imakhala ndi 25 mg gentamicin sulfate. Mankhwala ndi chinthu chomwe chikugwiritsidwa ntchito ndi mankhwala.

Mwa zina zothandizira ndi zomwe zilipo:

parafini wolimba (52 - 54),
mafuta parafini
paraffin yoyera yoyera.

Kenako, mupeza kuti mafuta amtengo wapatali a glamicin amawononga ndalama zingati.

Mlingo Wamitundu

Mankhwalawa amapezeka mu mawonekedwe a mafuta, omwe amagwiritsidwa ntchito kunja. Mkati mwa chubu muli 15 kapena 25 mg. mankhwala. Mtengo wa mafuta a glamicin ku Russia amayamba kuchokera ku ma ruble 57, zimatengera kuchuluka kwa mankhwalawa.

Komanso "Gentamicin" imapangidwa ngati ufa, yankho la jakisoni.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi nthawi yomweyo ya mankhwala aantamicin omwe amawonetsa oto-, nephrotic zotsatira zimatsutsana:

Kugwiritsa ntchito pamodzi nthawi imodzi ya mosaamicin ndi Furosemide kumapangidwanso.

Kugwiritsa ntchito "Mafuta a Gentamicin" tikulimbikitsidwa kuti musamachite zokonzekera zomwe zimakhala ndi K +, Mg ++, Na +, Ca ++ ions, anions (nitrate, phosphates, sulfates).

Kusagwirizana kwa gentamicin ndi mankhwala otsatirawa kunadziwika: heparin, mankhwala omwe amawoneka osakhazikika pa acidic pH, komanso ndi njira zomwe zili ndi alkaline pH.

About Mafuta a Gentamicin, odwala amasiya mayankho abwino, aliyense amakonda zotsatira zake zabwino za bactericidal, antimicrobial.
Nthawi yomweyo, mtengo wa mankhwalawo ndi wokwera mtengo.
Pamtengo wotsika, mtundu umakhalabe wokwera.

Onani ma fanizo otsatirawa:

"Gentamicin sulfate."
Tayzomed.
"Streptomycin sulfate."
"Tobrex 2x."
Kanamycin.
Isofra.

Kanemayu anena za kugwiritsa ntchito mankhwala a khutu la mankhanda matenda a khutu:

Maantibiotic agwira kalekale m'moyo wamunthu. Tsopano mutha kupeza mankhwala ochepetsa mphamvu ya antibacterial, sopo wa antibacterial, gel osakaniza kapena kupukuta, ndi zina zotero. Koma muyenera kugwiritsa ntchito njira zonse mosamala. Makamaka pankhani ya mankhwala. Nkhani ya lero ikufotokozerani zomwe Gentamicin-Akos ndi. Pazomwe mafuta omwe amagwiritsidwa ntchito, ndipo mukakhala bwino kuzikana, muphunziranso zambiri.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Popeza zotheka za ototoxic zimatha kuchitika pakumwa mankhwala a mafuta a hamamicin, kusamala pamafunika magalimoto poyendetsa magalimoto ndi kuchita zinthu zomwe zimafunikira kuti anthu azisamalira.

Mimba komanso kuyamwa

Pazinthu zochepa, gentamicin amadutsa mkaka wa m'mawere. Chifukwa cha kusamwa kwa mankhwalawa m'matumbo am'mimba, kukulira kwa zotsatira zoyipa nthawi yoyamwitsa kulibe mwayi.

Gwiritsani ntchito paubwana

Malinga ndi malangizo, mafuta a Gentamicin 0,1% amatsutsana mwa ana osakwana zaka 3.

Ndi mkhutu aimpso ntchito

Odwala omwe ali ndi vuto laimpso ayeneranso kuikidwa mosamala.

Gwiritsani ntchito mu ukalamba

Kugwiritsa ntchito mafuta onunkhira okalamba kumafunikira kusamala ndikuwunika kwa nthawi yake ntchito ya impso.

Chifukwa cha kuyamwa kocheperako, kuphatikiza kwakukulu kwa mankhwalawa ndi mankhwalawa sikungatheke. Zotheka zimayambitsa nthawi yomweyo kugwiritsa ntchito mafuta a hamamicin ndi zinthu zina:

anions (nitrate, phosphates, sulfates, etc.), sodium, potaziyamu, calcium, magnesium ion: kuchepa kwa ntchito ya gentamicin,
streptomycin, monomycin, florimycin, ristamycin ndi ma antibayotiki ena omwe ali ndi nephrotoxic ndi ototoxic komanso komanso furosemide: ntchito yogwirizana ndiomenamicin siyikulimbikitsidwa,
dioxidine: mphamvu ya glamicin chifukwa chophatikizika,
penicillin ndi cephalosporins: machulukitsidwe a gentamicin,
heparin, mayankho ndi alkaline pH, osakhazikika pa acidic pH mankhwala: kusagwirizana ndi ma glamicin,
corticosteroids: mungagwiritse ntchito kuphatikizira ndi gentamicin.

Mafuta a Gentamicin 0,1% analogues ndi Gentamicin ndi Gentamicin-AKOS.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani ku kutentha kosaposa 20 ° C. Pewani kufikira ana.

Moyo wa alumali ndi zaka zitatu.

Mankhwala Okhala Pamalo a Pharmacy

Yoperekedwa ndi mankhwala.

Ndemanga pa Mafuta a Gentamicin 0,1%

Mu ndemanga za mafuta a Gentamicin 0,1%, ogwiritsa ntchito amawona kuti mankhwalawa amathandizira kuchiritsa mabala osaya ndi kupsa, kuchita mwachangu komanso moyenera. Kuphatikiza apo, mafuta amtundu wotsika mtengo.

Mtengo wa mafuta a Gentamicin 0,1% m'masitolo ogulitsa mankhwala

Mtengo woyeserera wa mafuta a Gentamicin a 0% ndi pafupifupi ma ruble 70 pa chubu chilichonse cha 15 g.

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Gentamicin. Amapereka ndemanga kuchokera kwa alendo omwe amabwera pamalowo - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito mankhwala Gentamicin oletsa kupha. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Gentamicin analogues pali kupezeka kwa analogue. Gwiritsani ntchito pochiza matenda akulu, ana, komanso pa nthawi ya bere.

Gentamicin - Mankhwala othana ndi chitetezo cha gulu la aminoglycoside. Imakhala ndi bactericidal zotsatira. Mothandizidwa ndi bakiteriya cell cell, amalepheretsa kuphatikiza mapuloteni a pathogen.

Wogwira ntchito kwambiri motsutsana ndi bakiteriya wa aerobic gram-hasi: Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Serratia spp., Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp.

Yogwiranso ntchito motsutsana ndi aerobic gramu-cocci: Staphylococcus spp. (kuphatikizapo kugonjetsedwa ndi penicillin ndi maantibayotiki ena), zovuta zina za Streptococcus spp.

Neisseria meningitidis, Treponema pallidum, mavuto ena a Streptococcus spp., Mabakiteriya a Anaerobic amalimbana ndi gramicin.

Dexamethasone ndi mankhwala opangidwa ndi glucocorticosteroid (GCS), odana ndi kutupa komanso odana ndi matupi awo omwe amakhala okwana 25 kuposa zochita za cortisol, komwe ndi chilengedwe cha chilengedwe cha Gort. Kulowa kwa dexamethasone kudzera mu cornea ndi epithelium yolimba mu chinyezi cha chipinda chamaso cha diso ndikotheka, komabe, pakachitika njira yotupa kapena kuwonongeka kwa epithelium, kuchuluka kwa gawo la dexamethasone kudzera mu cornea kumakulitsa.

Kupanga

Gentamicin (mu mawonekedwe a sulfate) + owonetsa.

Dexamethasone sodium phosphate + Gentamicin sulfate + excipients (madontho a Dex ndi mafuta amaso).

Pharmacokinetics

Pambuyo pokonzekera intramuscular, imatengedwa mwachangu kuchokera pamalowo jekeseni. Kumanga mapuloteni a Plasma kumakhala kochepa (0-10%). Imagawidwa mu madzi akunja kwama cell onse amthupi. Imalowa mkati mwa chotchinga chachikulu. Osapukusidwa. 70-95% imachotsedwa mu mkodzo, pang'ono ndi ndulu.

Zizindikiro

matenda opatsirana komanso otupa oyambitsidwa ndi tizilombo tating'ono timene timayamwa mereamicin,
ntchito kwa makolo: pachimake cholecystitis, cholangitis, pyelonephritis, cystitis, chibayo, kuperewera kwamatenda, peritonitis, sepsis, ventriculitis, matenda amkati a khungu ndi minyewa yofewa, kutupa kwa zilonda, matenda opatsirana, matenda a mafupa ndi mafupa,
pa ntchito zakunja: pyoderma (incl.gangrenous), zapamwamba folliculitis, furunculosis, sycosis, paronychia, matenda a seborrheic dermatitis, kachilombo ziphuphu zakumaso, kachilombo ka kachilombo ka kachilombo ka fungus komanso matenda amtundu wa pakhungu, zilonda zapakhungu matenda osiyanasiyana etiologies (kupsa, mabala, kuvuta zilonda zam'mimba ,
ntchito wamba: blepharitis, blepharoconjunctivitis, dacryocystitis, conjunctivitis, keratitis, keratoconjunctivitis, meibomite.

Kutulutsa Mafomu

Mafuta a Gentamicin 0,1%

Diso limatsika 0,3% (Dex).

Njira yothetsera mtsempha wa magazi ndi mtsempha wa mkodzo (jakisoni m'mapiritsi a jakisoni).

Mitundu ina, kaya ndi mapiritsi kapena zonona, kulibe.

Malangizo ogwiritsira ntchito ndi mlingo

Khazikikani payekhapayekha, poganizira zovuta komanso kutengera kwa matendawa, kuzindikira kwa tizilombo toyambitsa matenda.

Mothandizidwa ndi mtsempha wa intravenous kapena mu mnofu wa akulu, limodzi ndi 1-1.7 mg / kg, tsiku lililonse la 3-5 mg / kg, pafupipafupi makonzedwe a 2-4 patsiku. Njira ya chithandizo ndi masiku 7-10. Kutengera ndi etiology yamatendawa, n`zotheka kugwiritsa ntchito mlingo wa 120-160 mg kamodzi patsiku kwa masiku 7-10 kapena 240-280 mg kamodzi. Kulowetsedwa kwa IV kumachitika kwa maola 1-2.

Kwa ana okulirapo kuposa zaka 2, tsiku lililonse mankhwalawa amakhala ndi 3-5 mg / kg, pafupipafupi makonzedwe ake ndi katatu patsiku. Ana oyamba kubadwa ndi ongobadwa kumene amawafotokozera tsiku lililonse 2-5 mg / kg, pafupipafupi makonzedwe ndi 2 kawiri patsiku, ana osakwana zaka 2 amafunsidwa kamodzi pamankhwala 3 pa tsiku.

Odwala omwe ali ndi vuto la kuwonongeka kwa impso amafunika kuwongolera dosing malinga ndi mfundo za QC.

Ikagwiritsidwa ntchito mopitilira muyeso, mankhwalawa amathandizira kutsika kwa mphindi ziwiri m'magawo atatu kapena atatu.

Kuti mugwiritse ntchito zakunja, gwiritsani ntchito katatu patsiku.

Mlingo wambiri tsiku lililonse: kwa akulu ndi ana omwe ali ndi iv kapena makonzedwe amkati - 5 mg / kg.

Zotsatira zoyipa

kusanza, kusanza,
kuchepa magazi, leukopenia, granulocytopenia, thrombocytopenia,
oliguria
proteinuria
michere
kulephera kwa aimpso
mutu
kugona
kusamva
ugonthi wosasintha
zotupa pakhungu
kuyabwa
urticaria
malungo
Edema wa Quincke.

Contraindication

Hypersensitivity to gentamicin ndi maantibayotiki ena a gulu la aminoglycoside,
makutu am'mitsempha,
kuvulala kwambiri aimpso,
uremia
mimba
mkaka wa m'mawere (yoyamwitsa).

Mimba komanso kuyamwa

Gentamicin imaphatikizidwa pakatundu. Ngati ndi kotheka, ntchito pa mkaka wa m`mawere ayenera kusiya kuyamwitsa.

Gwiritsani ntchito ana

Kugwiritsa ndikotheka malinga ndi mtundu wa mankhwalawa.

Malangizo apadera

Gentamicin imagwiritsidwa ntchito mosamala mu parkinsonism, myasthenia gravis, ndi vuto laimpso. Pogwiritsa ntchito gentamicin, ntchito za impso, makina owongolera komanso zida zapamwamba ziyenera kuyang'aniridwa.

Pogwiritsa ntchito mankhwalawa kwa khungu kwanthawi yayitali pakhungu lalikulu, ndikofunikira kulingalira kuti mungathe kugwiranso ntchito, makamaka kwa odwala omwe ali ndi vuto laimpso.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo ndi aminoglycosides, vancomycin, cephalosporins, ethaconic acid, kuchuluka kwa oto- ndi nephrotoxic kumatha.

Pogwiritsa ntchito munthawi yomweyo ndi indomethacin, pali kuchepa kwa chiwonetsero chazachilendo, kuwonjezeka kwa kuchuluka kwake m'magazi am'magazi, pomwe chiopsezo chokhala ndi poizoni chikukula.

Pogwiritsa ntchito munthawi yomweyo ndi ndalama zopangira ululu wamankhwala, ma analgesics opioid, chiopsezo chokhala ndi vuto la neuromuscular blockade limakulirakulira, mpaka kukula kwa ziphuphu zakumaso.

Pogwiritsa ntchito munthawi yomweyo kugwiritsa ntchito mankhwala ofanana aamamicin ndi "malupu" okodzetsa (furosemide, ethaconic acid), kuchuluka kwa magazi a mankhwalawa kumawonjezeka, chifukwa chake chiwopsezo chokhala ndi zotsatira zoyipa za thupi chikuwonjezeka.

Mndandanda wa mankhwala Gentamicin

Zofanana muzochitika zamagulu:

Garamycin,
Gentamicin Akos,
Gentamicin K,
Gentamicin Ferein,
Gentamicin sulfate,
Gentamicin sulfate jakisoni 4%,
Mafuta a Gentamicin.

Popeza pali mankhwala a analogi wa yogwira mankhwala, mutha kutsatira maulalo omwe ali pansipa ndi matenda omwe amathandizira mankhwala ndikuwona mawonekedwe ofananizira achire.

Zotsatira za pharmacological

Mankhwala omwe amafunsidwa nthawi zambiri amaphatikizidwa ndi gulu la aminoglycosides, ophthalmic agents. Gentamicin amadziwika ngati anti-bacterial antibacterial.

Mankhwala

Gentamicin imagwira ntchito motsutsana ndi tizilombo tosiyanasiyana. Imagwira pazinthu zosagonana zambiri, komanso ma tizilombo totsatirawa:

Serratia spp.,
Pseudomonas aeruginosa,
Salmonella spp.,
Escherichia coli,
Shigella spp.,
Staphylococcus spp.,
Proteus spp.

"Mafuta a Gentamicin" samakhudza mabakiteriya a anaerobic, fungi, ma virus. Mankhwalawa ali ndi bactericidal. Imalowa mkati mwa cell cell ya tizilombo. Kenako, atamangidwa a gentamicin ndi 30S subunits of ribosomes, mapuloteni kaphatikizidwe amalepheretseka tizilombo tating'onoting'ono.

Pharmacokinetics

Mankhwala omwe amafunsidwa amalowa pakhungu mofooka kwambiri. Mukamagwiritsira ntchito madera osakhazikika a khungu, ndi 0% yokha ya mankhwalawa yomwe imamweka.
Ngati mankhwalawa agwiritsidwa ntchito kumalo ovulazidwa a khungu, amamwe mosavuta. Ndi malo owonongeka, otentha khungu (1 cm2), kuyamwa kwa mankhwalawa kumawonjezeka kwambiri (mpaka 1.5 μg).
Kamodzi kamodzi kugwiritsa ntchito mankhwalawa ku genermis, mphamvu yake imadziwika kwa maola 8 mpaka 12. Kutulutsa kwa glamicin kuchokera mthupi kumachitika ndi impso. Amatuluka osasinthika chifukwa cha kusefera kwa glomerular.

Werengani za momwe mafuta amtengo wapatali a glamicin amagwiritsidwira ntchito pachipatala, kuchiritsa maso, ziphuphu ndi zomwe zimawerengedwa kuchokera kwa odwala, werengani.

Zisonyezero zogwiritsa ntchito mafuta onunkhira a folamu

Mankhwala amapatsidwa kuti athane ndi matenda opatsirana komanso otupa, omwe amapezeka omwe amakwiya ndi tizilombo tating'onoting'ono tomwe timayatsidwa ndi mankhwalawa. Mankhwala amagwiritsidwa ntchito pochiza:

matenda oyamba ndi matenda a epermermis (furunculosis, ziphuphu zopatsirana, impetigo, folliculitis wapamwamba),
matenda apakati pa khungu
komanso pa ntchito ya opaleshoni yochizira zilonda zam'mimbazi, zilonda zamkhungu zopweteka, mabala ang'ono, kuwotcha kwaposachedwa ndimatenda oyambitsidwa (giredi 3, 3A), mabala, zotupa pakhungu pambuyo poti ziwonekere.

Gentamicin ndi iyi:

Gentamecin imagwiritsidwanso ntchito pamaso pa maso a optic neuritis, chithandizo chovuta cha otitis media mu akulu, kuphatikizapo otitis externa, monga thandizo pamaso pa adenoma a prostate.

Buku lamalangizo

Mlingo wa wodwala aliyense amawerengeredwa payekha ndi adokotala omwe akuwathandiza. Kuti awerenge mlingo, dokotala amatengera kuthekera kwa zotupa, kuopsa kwa matendawa, kuchuluka kwa chidwi cha pathogen.

Kuti mugwiritse ntchito mankhwalawa, ndikofunikira kuchitira 3 mpaka 4 mankhwala patsiku. Ikani "mafuta a Gentamicin" kumalo ovuta a epidermis omwe ali ndi mawonekedwe ochepa. Ngati mafinya, maselo a necrotic alipo pagawo lomwe lakhudzidwalo, ayenera kuchotsedwa, ndiye kuti mafuta oyenera azithira. Ngati kuwonongeka kwa epidermis ndikofunikira, tikulimbikitsidwa kuyamwa tsiku lililonse mkati mwa 200 g mafuta.
Pochizira kuwonongeka kwa maso, mankhwalawa amagwiritsidwa ntchito ngati madontho. Mukufuna madontho 1 - 2, omwe amakhazikika mu conjunctival sac (m'munsi).
Ngati mankhwalawa amathandizidwa ndi intramuscularly, ndiye kuti mlingo umodzi ndi 1 mpaka 1.7 mg / kg. Potere, gawo la tsiku ndi tsiku ndi 3 mpaka 5 mg / kg.

Gentamicin imapangidwa pakakhala pakati. Izi ndichifukwa cha mawonekedwe kuti mankhwalawa amatha kulowa mu hematoplacental chotchinga, potero amafikira mwana wosabadwayo, minyewa yake. Malinga ndi kafukufuku wochitidwa ndi asayansi anyama, ma cocamicin amawonetsa kawopsedwe ochulukitsa.

Sizoletsedwa kugwiritsa ntchito mafuta a "Gentamicin" mu trimester yoyamba ya mimba. Ngati phindu lomwe limakonzekera mayiyo limachulukitsa chiopsezo cha mwana wosabadwayo, mankhwalawo amaloledwa kugwiritsidwa ntchito mu II, III trimesters.

Ngati mayi akuyamwitsa, ayenera kusiya kuyamwitsa panthawi ya chithandizo. Kusamala kumeneku ndikofunikira chifukwa ma glamicin amadutsa mkaka wa m'mawere. Popeza kupezeka kwa mankhwalawo m'matumbo amthupi, zotsatira zoyipa sizichitika.

Gentamicin itha kugwiritsidwanso ntchito ngati prostatitis, monga kanemayu akufotokozera:

Contraindication

Mwa zomwe akuphwanya, tikuwona izi:

Kukhalapo kwa hypersensitivity mwa wodwalayo kwa gawo likulu, lomwe ndi gentamicin.
Kukhalapo kwa chidwi chochulukirapo pazinthu zothandizira.
Kukhalapo kwa kulephera kwa impso.
Zaka zosakwana 3.
Kukhazikitsidwa kwa aminoglycosides.
Ndi mitsempha yam'mitsempha yamagetsi, ndikofunikira kugwiritsa ntchito mankhwalawa mosamala pochiza dera lalikulu la khungu.

Zotsatira zoyipa

Kugwiritsa ntchito mankhwala omwe mukufunsaku kungayambitse zotsatirazi:

Mu hematopoietic dongosolo: granulocytopenia, kuchepa magazi, leukopenia, thrombocytopenia.
M'mimba: hyperbilirubinemia, kusanza, nseru, kuchuluka kwa transaminase ntchito mu chiwindi.
Mumkodzo: micromaturia, proteinuria, kulephera kwaimpso, oliguria.
Mthupi lamanjenje (CNS, zotumphukira za NS): kugona, ugonthi wosasinthika, kupweteka kwa mutu, kusokonezeka kwa magwiridwe antchito a vetibular, kumva makutu, kuphwanya kwamisempha.

Kuphatikiza pazotsatira zoyipa zomwe zili pamwambazi, odwala amathanso kukhudzidwa ndi mawonekedwe a zotupa pakhungu, kuyabwa, urticaria, kawirikawiri monga mawonekedwe a Quincke a edema.

Malangizo apadera

Mankhwala ayenera kugwiritsidwa ntchito mosamala pamaso pa matenda monga myasthenia gravis, parkinsonism, matenda aimpso.
Kugwiritsa ntchito "Mafuta a Gentamicin" pazithandizo zamankhwala pamalo ambiri a epithelium, musaiwale za kupatsanso mphamvu kwa mankhwalawa. Makamaka, izi zimagwira ntchito kwa iwo omwe ali ndi vuto la aimpso (aakulu).
Kugwiritsa ntchito kwawoko kungathandizire kukulitsa chidwi cha tizilombo toyambitsa matenda osiyanasiyana. Pokhapokha pakuwoneka zochizira, wodwalayo afunika uphungu waluso.
Pafupipafupi mawonekedwe owoneka amakumana ndi 1.4%. Milandu yokhudzana ndi chidwi imachitika pafupipafupi mukamagwiritsa ntchito mafuta onunkhira kwakanthawi. Zotsatira zoyipa nthawi zambiri zimawonekera bwino mukalandira chithandizo cha mankhwala a madera akuluakulu a khungu.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi nthawi yomweyo ya mankhwala aantamicin omwe amawonetsa oto-, nephrotic zotsatira zimatsutsana:

Kugwiritsa ntchito pamodzi nthawi imodzi ya mosaamicin ndi Furosemide kumapangidwanso.

Kugwiritsa ntchito "Mafuta a Gentamicin" tikulimbikitsidwa kuti musamachite zokonzekera zomwe zimakhala ndi K +, Mg ++, Na +, Ca ++ ions, anions (nitrate, phosphates, sulfates).

Kusagwirizana kwa gentamicin ndi mankhwala otsatirawa kunadziwika: heparin, mankhwala omwe amawoneka osakhazikika pa acidic pH, komanso ndi njira zomwe zili ndi alkaline pH.

About Mafuta a Gentamicin, odwala amasiya mayankho abwino, aliyense amakonda zotsatira zake zabwino za bactericidal, antimicrobial.
Nthawi yomweyo, mtengo wa mankhwalawo ndi wokwera mtengo.
Pamtengo wotsika, mtundu umakhalabe wokwera.

Onani ma fanizo otsatirawa:

"Gentamicin sulfate."
Tayzomed.
"Streptomycin sulfate."
"Tobrex 2x."
Kanamycin.
Isofra.

Kanemayu anena za kugwiritsa ntchito mankhwala a khutu la mankhanda matenda a khutu:

Pharmacology yamankhwala: momwe mankhwalawo amagwirira ntchito, omwe sangathe kupirira nawo?

Kodi malangizo ogwiritsira ntchito akuti chiyani: zikuwonetsa ndi contraindication

bakiteriya matenda akhungu
gangodous pyoderma,
furunculosis ndi zapamwamba folliculitis,
paronychia, sycosis,
seborrheic dermatitis (kachilombo),
ziphuphu
Zilonda zoyambitsidwa ndi mitsempha ya varicose.

Osagwiritsa ntchito mafuta ndi hypersensitivity kwa yogwira thunthu, neuritis yamitsempha yamagazi. Matenda akulu aimpso, uremia, mkaka wa m'mimba komanso pakati amakhalanso ndi zotsutsana.

Dermatitis ya eczematous: kugwiritsa ntchito mafuta a antibacterial

Koma zimachitikanso kuti thovu lomwe linayambika limayamba kuphulika kapena kutsegulidwa ndi munthu wodwalayo. Pankhaniyi, matenda achiwiri amachitika. Panthawi imeneyi, mankhwala "Gentamicin-Akos" ndi omwe amakhazikitsidwa. Kodi mafutawa amagwiritsidwa ntchito bwanji ngati zotere? Mankhwalawa amatha kuthetsa kachilombo komwe kamalowa. Izi zikuthandizira kuchira mwachangu. Ikani mankhwala kunja, kawiri pa tsiku. Ngati mafuta owonjezera agwiritsidwa ntchito, ndiye kuti muyenera kusiya pakati pawo.

Kodi Gentamicin-Akos angathandize ndi matenda otchedwa paronychia?

Chithandizo cha zotsekemera za periungual zambiri nthawi zambiri chimayendera limodzi ndi mankhwala a antibacterial.Zomwe zimayambitsa matendawa zimatha kukhala zosiyanasiyana: kachilombo ka virus kapena fungus, kuvulala, ma radiation, manicure osayenera, ndi zina zotero. Ngati kusamba kwayamba, komwe kumayambitsa matenda a paronychia, chithandizo chikuyenera kuyenderana ndi kugwiritsa ntchito maantibayotiki.

Ndemanga zake zomwe zidzakhale zosangalatsa kudziwa wogula

M'malo momaliza

Mafuta a Gentamicin 0,1% ndi mankhwala ochepetsa mphamvu ya bakiteriya omwe ali ndi bactericidal zotsatira zakunja.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mafuta ogwiritsira ntchito zakunja kwa 0,1%: kuchokera ku chikasu mpaka kuyera (mu chubu cha aluminium 15 g, mu katoni ka 1 tube).

Kupanga 1 g mafuta:

yogwira thunthu - mankhwalawa (mwa mankhidwe a mankhwalawa) - 0,001 g,
zopereka: mafuta olimba a parafini, mafuta oyera oyera oyera.

Mankhwala

Gentamicin, mankhwala ochulukitsa owonetsa, ali m'gulu la aminoglycosides a m'badwo wachiwiri. Mosiyana ndi ma bacteriostatic antibayotiki, aminoglycosides mwachindunji amachititsa kufa kwa tizilombo tating'onoting'ono timene timawaganizira, mosaganizira gawo lomwe adaberekera. Makina a bactericidal a gentamicin ndi omwe amalowerera mkati mwa mabakiteriya kudzera mu membrane wam'maselo, chosasinthika chomangira ma ribosomes a bacteria kupita ku 30S subunits, ndikupanga mawonekedwe ovuta a mayendedwe a ribonucleic acid (tRNA) ndi matrix ribonucleic acid (mRNA). Chifukwa chake, galamamin amasokoneza zotchinga za michere ya cytoplasmic ya tizilombo tating'onoting'ono ndipo timalepheretsa kaphatikizidwe kazakudya mapuloteni.

Gentamicin sulfate imagwira ntchito motsutsana ndi mitundu yotsatirayi ya aerobic gram-negative tizilombo: Salmonella spp., Shigella spp., Escherichia coli, Serratia spp., Klebsiella spp., Enterobacter spp., Acinetobacter spp, Pseudomonas aeruginosa, Proteuspp. (wosaletseka komanso wosazindikira).

Mankhwalawa amagwiritsidwanso ntchito motsutsana ndi mabakiteriya olimbitsa thupi aerobic gram monga Staphylococcus spp. (kuphatikizapo penicillin-ndi methicillin zosagwira zovuta), zovuta zina za Streptococcus spp.

Kukana kwa glamicin kukuwonetsedwa ndi Treponema pallidum, Neisseria meningitidis, mabakiteriya a anaerobic, ena a Streptococcus spp.

Pharmacokinetics

Zogwiritsa ntchito panja, ma samelin samatengeka pakhungu loyipa. Ikagwiritsidwa ntchito m'malo akuluakulu akhungu, komanso yowonongeka kapena yokutidwa ndi minyewa, khungu limatengeka mosavuta komanso mwachangu. Kuyamwa kwachilengedwe ndi 1 cm2 yamafuta pamoto woyaka kapena wa zilonda kumatha kufika 1.5 ofg yaneneamicin. Thupi limachotsedwa osasinthika ndi impso, makamaka chifukwa cha kusefera kwamadzi.

Zizindikiro zogwiritsidwa ntchito

matenda oyamba ndi bakiteriya a pakhungu ndi (kapena) minofu yofewa yomwe imayambitsidwa ndi microflora yovuta:: folliculitis yapamwamba, pyoderma (kuphatikizapo gangrenous), furunculosis, paronychia, sycosis, ziphuphu zopatsirana,
matenda apakhungu a pakhungu: dermatitis yomwe ili ndi kachilombo (kuphatikiza seborrheic, kulumikizana ndi chikanga), kupatsirana kwa ma bacteria pakhungu komanso zotupa pakhungu,
zotupa zapakhungu zodwala matendawa osiyanasiyana: mabala (kuphatikiza sagging, opaleshoni), mabala, kuwotcha (kwapamwamba, II - IIIA madigiri), zilonda zam'mimba (kuphatikizapo varicose), kulumwa ndi tizilombo,
zotupa pakhungu ndi cysts (mutatsegula ndi kukhetsa).

munthawi yomweyo makonzedwe aminoglycosides,
trimester yoyamba ya mimba
zaka mpaka zaka zitatu
kukulitsa chidwi chamunthu payekha kwa gentamicin kapena aminoglycosides ena.

aakulu aimpso kulephera
wachiwiri ndi wachitatu trimester wa mimba, kuyamwa,
ukalamba.

Mafuta a Gentamicin 0,1% ayenera kugwiritsidwa ntchito mosamala ngati pakufunika kuikapo m'malo akulu pakhungu odwala omwe ali ndi ma nerve neuritis, parkinsonism, myasthenia, botulism.

Malangizo ogwiritsira ntchito mafuta a Gentamicin 0,1%: njira ndi mlingo

Pogwiritsa ntchito mafuta a Gentamicin 0,1%, mawonetseredwe am'deralo okhumudwitsa (kutentha thupi, kuyabwa, redness), matupi awo sagwirizana (urticaria, zotupa pakhungu, kuyabwa, kutentha thupi, eosinophilia, angioedema). Ngati thupi lanu lisagwedezeka, mankhwalawo amachotsedwa ndipo amayamba kufooka.

Mukamagwiritsa ntchito mafuta aokomolicin kwa nthawi yayitali m'malo akuluakulu a khungu, mutha kugwiranso ntchito, makamaka kwa odwala omwe ali ndi vuto laimpso.

Mukatha kugwiritsa ntchito mankhwalawa pamalo akulu pachilondacho kapena kuwotcha, makamaka ngati mukugwiritsidwa ntchito kwa nthawi yayitali, nephrotic, ototoxic, ndi vestibular.

Popeza mankhwalawa ali ndi mayamwidwe otsika, mankhwalawa ndi osatheka.

Mafuta a Gentamicin 0,1% sagwiritsidwa ntchito pakugwiritsa ntchito mucous nembanemba, kuphatikiza pamaso.

Pogwiritsa ntchito mafuta onunkhira a glamicin, kukula kwa kukana ndikotheka.

Mankhwala ali osavomerezeka kuti agwiritsidwe ntchito munthawi yomweyo mankhwala a aminoglycoside antibayotiki chifukwa chowonjezera chiopsezo cha zotsatira zoyipa.

Ngati 1 sabata ntchito mafuta, achire zotsatira kulibe, ndikofunikira kukaonana ndi katswiri.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Popeza zotheka za ototoxic zimatha kuchitika pakumwa mankhwala a mafuta a hamamicin, kusamala pamafunika magalimoto poyendetsa magalimoto ndi kuchita zinthu zomwe zimafunikira kuti anthu azisamalira.

Mimba komanso kuyamwa

Pazinthu zochepa, gentamicin amadutsa mkaka wa m'mawere. Chifukwa cha kusamwa kwa mankhwalawa m'matumbo am'mimba, kukulira kwa zotsatira zoyipa nthawi yoyamwitsa kulibe mwayi.

Gwiritsani ntchito paubwana

Malinga ndi malangizo, mafuta a Gentamicin 0,1% amatsutsana mwa ana osakwana zaka 3.

Ndi mkhutu aimpso ntchito

Odwala omwe ali ndi vuto laimpso ayeneranso kuikidwa mosamala.

Gwiritsani ntchito mu ukalamba

Kugwiritsa ntchito mafuta onunkhira okalamba kumafunikira kusamala ndikuwunika kwa nthawi yake ntchito ya impso.

Chifukwa cha kuyamwa kocheperako, kuphatikiza kwakukulu kwa mankhwalawa ndi mankhwalawa sikungatheke. Zotheka zimayambitsa nthawi yomweyo kugwiritsa ntchito mafuta a hamamicin ndi zinthu zina:

anions (nitrate, phosphates, sulfates, etc.), sodium, potaziyamu, calcium, magnesium ion: kuchepa kwa ntchito ya gentamicin,
streptomycin, monomycin, florimycin, ristamycin ndi ma antibayotiki ena omwe ali ndi nephrotoxic ndi ototoxic komanso komanso furosemide: ntchito yogwirizana ndiomenamicin siyikulimbikitsidwa,
dioxidine: mphamvu ya glamicin chifukwa chophatikizika,
penicillin ndi cephalosporins: machulukitsidwe a gentamicin,
heparin, mayankho ndi alkaline pH, osakhazikika pa acidic pH mankhwala: kusagwirizana ndi ma glamicin,
corticosteroids: mungagwiritse ntchito kuphatikizira ndi gentamicin.

Mafuta a Gentamicin 0,1% analogues ndi Gentamicin ndi Gentamicin-AKOS.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani ku kutentha kosaposa 20 ° C. Pewani kufikira ana.

Moyo wa alumali ndi zaka zitatu.

Mankhwala Okhala Pamalo a Pharmacy

Yoperekedwa ndi mankhwala.

Ndemanga pa Mafuta a Gentamicin 0,1%

Mtengo wa mafuta a Gentamicin 0,1% m'masitolo ogulitsa mankhwala

Mtengo woyeserera wa mafuta a Gentamicin a 0% ndi pafupifupi ma ruble 70 pa chubu chilichonse cha 15 g.

Yogwiranso ntchito motsutsana ndi aerobic gramu-cocci: Staphylococcus spp. (kuphatikizapo kugonjetsedwa ndi penicillin ndi maantibayotiki ena), zovuta zina za Streptococcus spp.

Neisseria meningitidis, Treponema pallidum, mavuto ena a Streptococcus spp., Mabakiteriya a Anaerobic amalimbana ndi gramicin.

Kupanga

Gentamicin (mu mawonekedwe a sulfate) + owonetsa.

Dexamethasone sodium phosphate + Gentamicin sulfate + excipients (madontho a Dex ndi mafuta amaso).

Pharmacokinetics

Zizindikiro

matenda opatsirana komanso otupa oyambitsidwa ndi tizilombo tating'ono timene timayamwa mereamicin,
ntchito kwa makolo: pachimake cholecystitis, cholangitis, pyelonephritis, cystitis, chibayo, kuperewera kwamatenda, peritonitis, sepsis, ventriculitis, matenda amkati a khungu ndi minyewa yofewa, kutupa kwa zilonda, matenda opatsirana, matenda a mafupa ndi mafupa,
ntchito zakunja: pyoderma (kuphatikizapo gangrenous), zapamwamba folliculitis, furunculosis, sycosis, paronychia, matenda a seborrheic dermatitis, ziphuphu zakumaso, kachilombo ka bakiteriya kachilombo ka fungal ndi matenda a pakhungu, zilonda zapakhungu zamatenda osiyanasiyana a etiologies (kupsa, mabala, zilonda zam'mimba zopweteka, kulumidwa ndi tizilombo, zilonda zam'mimba za varicose,
ntchito wamba: blepharitis, blepharoconjunctivitis, dacryocystitis, conjunctivitis, keratitis, keratoconjunctivitis, meibomite.

Kutulutsa Mafomu

Mafuta a Gentamicin 0,1%

Diso limatsika 0,3% (Dex).

Njira yothetsera mtsempha wa magazi ndi mtsempha wa mkodzo (jakisoni m'mapiritsi a jakisoni).

Mitundu ina, kaya ndi mapiritsi kapena zonona, kulibe.

Malangizo ogwiritsira ntchito ndi mlingo

Khazikikani payekhapayekha, poganizira zovuta komanso kutengera kwa matendawa, kuzindikira kwa tizilombo toyambitsa matenda.

Kwa ana okulirapo kuposa zaka 2, tsiku lililonse mankhwalawa amakhala ndi 3-5 mg / kg, pafupipafupi makonzedwe ake ndi katatu patsiku.Ana oyamba kubadwa ndi ongobadwa kumene amawafotokozera tsiku lililonse 2-5 mg / kg, pafupipafupi makonzedwe ndi 2 kawiri patsiku, ana osakwana zaka 2 amafunsidwa kamodzi pamankhwala 3 pa tsiku.

Odwala omwe ali ndi vuto la kuwonongeka kwa impso amafunika kuwongolera dosing malinga ndi mfundo za QC.

Ikagwiritsidwa ntchito mopitilira muyeso, mankhwalawa amathandizira kutsika kwa mphindi ziwiri m'magawo atatu kapena atatu.

Kuti mugwiritse ntchito zakunja, gwiritsani ntchito katatu patsiku.

Mlingo wambiri tsiku lililonse: kwa akulu ndi ana omwe ali ndi iv kapena makonzedwe amkati - 5 mg / kg.

Zotsatira zoyipa

kusanza, kusanza,
kuchepa magazi, leukopenia, granulocytopenia, thrombocytopenia,
oliguria
proteinuria
michere
kulephera kwa aimpso
mutu
kugona
kusamva
ugonthi wosasintha
zotupa pakhungu
kuyabwa
urticaria
malungo
Edema wa Quincke.

Contraindication

Hypersensitivity to gentamicin ndi maantibayotiki ena a gulu la aminoglycoside,
makutu am'mitsempha,
kuvulala kwambiri aimpso,
uremia
mimba
mkaka wa m'mawere (yoyamwitsa).

Mimba komanso kuyamwa

Gentamicin imaphatikizidwa pakatundu. Ngati ndi kotheka, ntchito pa mkaka wa m`mawere ayenera kusiya kuyamwitsa.

Gwiritsani ntchito ana

Kugwiritsa ndikotheka malinga ndi mtundu wa mankhwalawa.

Malangizo apadera

Pogwiritsa ntchito mankhwalawa kwa khungu kwanthawi yayitali pakhungu lalikulu, ndikofunikira kulingalira kuti mungathe kugwiranso ntchito, makamaka kwa odwala omwe ali ndi vuto laimpso.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo ndi aminoglycosides, vancomycin, cephalosporins, ethaconic acid, kuchuluka kwa oto- ndi nephrotoxic kumatha.

Pogwiritsa ntchito munthawi yomweyo ndi indomethacin, pali kuchepa kwa chiwonetsero chazachilendo, kuwonjezeka kwa kuchuluka kwake m'magazi am'magazi, pomwe chiopsezo chokhala ndi poizoni chikukula.

Mndandanda wa mankhwala Gentamicin

Zofanana muzochitika zamagulu:

Garamycin,
Gentamicin Akos,
Gentamicin K,
Gentamicin Ferein,
Gentamicin sulfate,
Gentamicin sulfate jakisoni 4%,
Mafuta a Gentamicin.

Popeza pali mankhwala a analogi wa yogwira mankhwala, mutha kutsatira maulalo omwe ali pansipa ndi matenda omwe amathandizira mankhwala ndikuwona mawonekedwe ofananizira achire.

Zolemba za mankhwala

Mankhwala omwe amawaganizira ndi ntchito yayitali angayambitse kukana kwa tizilombo toyambitsa matenda tizilombo toyambitsa matenda.
Ngati odwala omwe akudwala aimpso amalephera kugwiritsa ntchito mankhwala pochotsa khungu.
Mankhwalawa akhoza kulowetsedwa pang'ono m'magazi, ndikuwonetsa kuchiritsa kwake.
Ngati mutagwiritsa ntchito mankhwalawa kwa nthawi yayitali njira zochizira sizikuwoneka, ndikofunikira kusiya kugwiritsa ntchito, funsani katswiri.

Tiyeni tionenso kuphatikizidwa kwa mafuta onenepa.

Mafuta a Gentamicin kuchokera ku Actavis (chithunzi)

Chubu yamadzi imakhala ndi 25 mg gentamicin sulfate. Mankhwala ndi chinthu chomwe chikugwiritsidwa ntchito ndi mankhwala.

Mwa zina zothandizira ndi zomwe zilipo:

parafini wolimba (52 - 54),
mafuta parafini
paraffin yoyera yoyera.

Kenako, mupeza kuti mafuta amtengo wapatali a glamicin amawononga ndalama zingati.

Mlingo Wamitundu

Komanso "Gentamicin" imapangidwa ngati ufa, yankho la jakisoni.

Zotsatira za pharmacological

Mankhwala omwe amafunsidwa nthawi zambiri amaphatikizidwa ndi gulu la aminoglycosides, ophthalmic agents. Gentamicin amadziwika ngati anti-bacterial antibacterial.

Mankhwala

Gentamicin imagwira ntchito motsutsana ndi tizilombo tosiyanasiyana. Imagwira pazinthu zosagonana zambiri, komanso ma tizilombo totsatirawa:

Serratia spp.,
Pseudomonas aeruginosa,
Salmonella spp.,
Escherichia coli,
Shigella spp.,
Staphylococcus spp.,
Proteus spp.

Pharmacokinetics

Mankhwala omwe amafunsidwa amalowa pakhungu mofooka kwambiri. Mukamagwiritsira ntchito madera osakhazikika a khungu, ndi 0% yokha ya mankhwalawa yomwe imamweka.
Ngati mankhwalawa agwiritsidwa ntchito kumalo ovulazidwa a khungu, amamwe mosavuta. Ndi malo owonongeka, otentha khungu (1 cm2), kuyamwa kwa mankhwalawa kumawonjezeka kwambiri (mpaka 1.5 μg).
Kamodzi kamodzi kugwiritsa ntchito mankhwalawa ku genermis, mphamvu yake imadziwika kwa maola 8 mpaka 12. Kutulutsa kwa glamicin kuchokera mthupi kumachitika ndi impso. Amatuluka osasinthika chifukwa cha kusefera kwa glomerular.

Werengani za momwe mafuta amtengo wapatali a glamicin amagwiritsidwira ntchito pachipatala, kuchiritsa maso, ziphuphu ndi zomwe zimawerengedwa kuchokera kwa odwala, werengani.

Zisonyezero zogwiritsa ntchito mafuta onunkhira a folamu

matenda oyamba ndi matenda a epermermis (furunculosis, ziphuphu zopatsirana, impetigo, folliculitis wapamwamba),
matenda apakati pa khungu
komanso pa ntchito ya opaleshoni yochizira zilonda zam'mimbazi, zilonda zamkhungu zopweteka, mabala ang'ono, kuwotcha kwaposachedwa ndimatenda oyambitsidwa (giredi 3, 3A), mabala, zotupa pakhungu pambuyo poti ziwonekere.

Gentamicin ndi iyi:

Pafupi. Amathandizira pochiza matenda otere: dacryocystitis, blepharitis, meibomite, conjunctivitis, blepharoconjunctivitis, keratoconjunctivitis, keratitis.
Kholo. Amathandizira mankhwalawa a cholangitis, cyriculitis, pachimake cholecystitis, chibayo, matenda am'mimba, sepsis, kupweteka kwam'mimba, matenda am'mafupa / mafupa, matenda opatsirana a epermermis, pyelonephritis, peritonitis, matenda opatsirana a minofu yofewa, kuwotcha matenda.
Kunja. Zimathandizira polimbana ndi ziphuphu zakumaso, folliculitis yapamwamba, kachilombo koyambira, sycosis, furunculosis, pyoderma, zilonda zam'mimba za varicose, zilonda zapakhungu zopezeka ndi maumbadwa osiyanasiyana (zilonda zam'mimba, kuwotcha, kuvuta kuchiritsa zilonda, mabala).

Gentamecin imagwiritsidwanso ntchito pamaso pa maso a optic neuritis, chithandizo chovuta cha otitis media mu akulu, kuphatikizapo otitis externa, monga thandizo pamaso pa adenoma a prostate.

Buku lamalangizo

Kuti mugwiritse ntchito mankhwalawa, ndikofunikira kuchitira 3 mpaka 4 mankhwala patsiku. Ikani "mafuta a Gentamicin" kumalo ovuta a epidermis omwe ali ndi mawonekedwe ochepa. Ngati mafinya, maselo a necrotic alipo pagawo lomwe lakhudzidwalo, ayenera kuchotsedwa, ndiye kuti mafuta oyenera azithira. Ngati kuwonongeka kwa epidermis ndikofunikira, tikulimbikitsidwa kuyamwa tsiku lililonse mkati mwa 200 g mafuta.
Pochizira kuwonongeka kwa maso, mankhwalawa amagwiritsidwa ntchito ngati madontho. Mukufuna madontho 1 - 2, omwe amakhazikika mu conjunctival sac (m'munsi).
Ngati mankhwalawa amathandizidwa ndi intramuscularly, ndiye kuti mlingo umodzi ndi 1 mpaka 1.7 mg / kg. Potere, gawo la tsiku ndi tsiku ndi 3 mpaka 5 mg / kg.

Gentamicin itha kugwiritsidwanso ntchito ngati prostatitis, monga kanemayu akufotokozera:

Contraindication

Mwa zomwe akuphwanya, tikuwona izi:

Kukhalapo kwa hypersensitivity mwa wodwalayo kwa gawo likulu, lomwe ndi gentamicin.
Kukhalapo kwa chidwi chochulukirapo pazinthu zothandizira.
Kukhalapo kwa kulephera kwa impso.
Zaka zosakwana 3.
Kukhazikitsidwa kwa aminoglycosides.
Ndi mitsempha yam'mitsempha yamagetsi, ndikofunikira kugwiritsa ntchito mankhwalawa mosamala pochiza dera lalikulu la khungu.

Zotsatira zoyipa

Kugwiritsa ntchito mankhwala omwe mukufunsaku kungayambitse zotsatirazi:

Mu hematopoietic dongosolo: granulocytopenia, kuchepa magazi, leukopenia, thrombocytopenia.
M'mimba: hyperbilirubinemia, kusanza, nseru, kuchuluka kwa transaminase ntchito mu chiwindi.
Mumkodzo: micromaturia, proteinuria, kulephera kwaimpso, oliguria.
Mthupi lamanjenje (CNS, zotumphukira za NS):kugona, ugonthi wosasinthika, kupweteka kwa mutu, kusokonezeka kwa magwiridwe antchito a vetibular, kumva makutu, kuphwanya kwamisempha.

Kuphatikiza pazotsatira zoyipa zomwe zili pamwambazi, odwala amathanso kukhudzidwa ndi mawonekedwe a zotupa pakhungu, kuyabwa, urticaria, kawirikawiri monga mawonekedwe a Quincke a edema.

Malangizo apadera

Mankhwala ayenera kugwiritsidwa ntchito mosamala pamaso pa matenda monga myasthenia gravis, parkinsonism, matenda aimpso.
Kugwiritsa ntchito "Mafuta a Gentamicin" pazithandizo zamankhwala pamalo ambiri a epithelium, musaiwale za kupatsanso mphamvu kwa mankhwalawa. Makamaka, izi zimagwira ntchito kwa iwo omwe ali ndi vuto la aimpso (aakulu).
Kugwiritsa ntchito kwawoko kungathandizire kukulitsa chidwi cha tizilombo toyambitsa matenda osiyanasiyana.Pokhapokha pakuwoneka zochizira, wodwalayo afunika uphungu waluso.
Pafupipafupi mawonekedwe owoneka amakumana ndi 1.4%. Milandu yokhudzana ndi chidwi imachitika pafupipafupi mukamagwiritsa ntchito mafuta onunkhira kwakanthawi. Zotsatira zoyipa nthawi zambiri zimawonekera bwino mukalandira chithandizo cha mankhwala a madera akuluakulu a khungu.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi nthawi yomweyo ya mankhwala aantamicin omwe amawonetsa oto-, nephrotic zotsatira zimatsutsana:

Kugwiritsa ntchito pamodzi nthawi imodzi ya mosaamicin ndi Furosemide kumapangidwanso.

Kusagwirizana kwa gentamicin ndi mankhwala otsatirawa kunadziwika: heparin, mankhwala omwe amawoneka osakhazikika pa acidic pH, komanso ndi njira zomwe zili ndi alkaline pH.

About Mafuta a Gentamicin, odwala amasiya mayankho abwino, aliyense amakonda zotsatira zake zabwino za bactericidal, antimicrobial.
Nthawi yomweyo, mtengo wa mankhwalawo ndi wokwera mtengo.
Pamtengo wotsika, mtundu umakhalabe wokwera.

Onani ma fanizo otsatirawa:

"Gentamicin sulfate."
Tayzomed.
"Streptomycin sulfate."
"Tobrex 2x."
Kanamycin.
Isofra.

Kanemayu anena za kugwiritsa ntchito mankhwala a khutu la mankhanda matenda a khutu:

ntchito yogwira - kindamicin (mwa mtundu wa sulamicin sulfate) - 25 mg,

obwera - parafini wolimba 52-54, parafini yamadzi, paraffin yofewa, yoyera.

Zotsatira za pharmacological

Gentamicin imadziwika ndi mawonekedwe osiyanasiyana a antimicrobial zochita. Imagwira pakulimbana ndi micera yambiri yama gramu-gramu komanso gram-virus: Pseudomonas aeruginosa, Escherichia coli, Proteus spp., Klebsiella spp., Serratia spp., Salmonella spp., Shigella spp, Staphylococcus spp. Mankhwalawa sasokoneza mabakiteriya a anaerobic, bowa, ma virus. Imakhala ndi bactericidal zotsatira. Kulowa mkati mwa cell membrane wa bakiteriya, kumangiriza ku gawo la 30S la bacteric ribosomes ndikuletsa ma protein a pathogen.

Mimba komanso kuyamwa

Gentamicin imalowa mu chotchinga cha hematoplacental ndikufikira mu minofu ya fetal. Kafukufuku wazinyama awonetsa kuwopsa kwa kubereka kwa gentamicin.

Mafuta a Gentamicin sayenera kugwiritsidwa ntchito munthawi yoyamba kubereka. Mu ma trimesters a II-III, kugwiritsa ntchito mafuta a glamicin ndikotheka pomwe phindu lomwe limafunikira kwa mayi likupereka chiwopsezo cha mwana wosabadwayo.

Gentamicin amamuchotsera mkaka wochepa ndi mkaka wa m'mawere. Chifukwa cha kusamwa kwa mankhwalawa kuchokera m'matumbo am'mimba, kupezeka kwa zovuta panthawi yoyamwitsa sikungatheke.

Mlingo ndi makonzedwe

Mafuta a Gentamicin amamugwiritsa ntchito kunja kuti aume khungu.

Mankhwalawa umagwiritsidwa ntchito kumalo akhudzidwa ndi khungu pambuyo pochotsa mafinya ndi ma necrotic, ndi woonda wowonda katatu patsiku, ndikuwotcha - katatu pa sabata. Ndi kuvulala kwakukulu, mafuta a tsiku ndi tsiku sayenera kupitirira 200 g (200 mg ya antiotic). Kutalika kwa mankhwalawa kumatengera mawonekedwe ndi kuuma kwa matendawa ndipo ndi masiku 7-14.

Mankhwalawa dermatological matenda, mankhwalawa umagwiritsidwa ntchito wowonda malo omwe akukhudzidwira katatu patsiku, kapena umagwiritsidwa ntchito pa bandeji yotseketsa yotsatira pakhungu lakhudzidwa. Kutalika kwa chithandizo ndi masiku 7-14.

Pamaso pa zilonda zotupa ndi kukokoloka, wotsukidwa kale ndi zothetsera za furatsilina (1: 5000), hydrogen peroxide (3%).

Zotsatira zoyipa

Mukamagwiritsa ntchito mafuta a hamamicin, zotsatira zoyipa (redness, kuyabwa, moto woyaka), thupi lawo siligwirizana (zotupa pakhungu, kuyabwa, urticaria, malungo, angioedema, eosinophilia). Ngati thupi lanu siligwirizana, mankhwalawo amatha ndipo amayamba kufooka.

Pogwiritsa ntchito mankhwalawa kwa khungu kwanthawi yayitali pakhungu lalikulu, ndikofunikira kulingalira kuti mungathe kugwiranso ntchito, makamaka kwa odwala omwe ali ndi vuto laimpso.

Pambuyo opaka mafuta onunkhira a glamicin, makamaka kugwiritsa ntchito mafuta nthawi yayitali pachilonda cha malo akulu, zotsatira za ototoxic, vestibular ndi nephrotic zimatheka.

Kuchita ndi mankhwala ena

Sayenera kuikidwa munthawi yomweyo ndi maantibayotiki ena omwe ali ndi vuto la oto- and nephrotoxic (streptomycin, kanamycin, florimycin, monomycin, ristamycin), lomwe lili ndi furosemide. Zochita za Gentamicin zimachepa pamaso pa Na +, K +, Ca ++, Mg ++ ions, komanso anions angapo (sulfates, phosphates, nitrate, ndi zina). Pali umboni wa kuphatikiza kwa synergistic wa mereamicin ndi dioxidine. Mwina mungagwiritse ntchito pamodzi corticosteroids.

Mu vitro, aminoglycosides samapangidwa ndi ma penicillin ndi cephalosporins chifukwa chogwirana ndi mphete ya β-lactam. Gentamicin sigwirizana ndi heparin, mayankho ndi alkaline pH komanso ndi mankhwala osakhazikika pa acidic pH.

Njira zopewera kupewa ngozi

Gentamicin sulfate ndi bactericidal wothandizila amene sagwira ntchito mu matenda a khungu kapena fungal.

Kuchiza kumachitika motsogozedwa ndi mankhwala othana ndi mankhwalawa, popeza kugwiritsa ntchito mankhwala opha maantibayotiki, kuphatikiza ndi mankhono, kungayambitse kukula kwa tizilombo toyambitsa matenda, kuphatikizapo bowa. Pankhaniyi, komanso ngati pakukwiya pakhungu, matupi awo sagwirizana kapena kupatsirana kwakukulu, mankhwalawa ali ndi mankhwalawa ayenera kusokonezedwa ndipo chithandizo choyenera chikuyenera kuchitika.

Ngati mkati mwa sabata limodzi palibe zochizira, muyenera kufunsa dokotala.

Mafuta a Gentamicin osavomerezeka kuti agwiritsidwe ntchito ndi makonzedwe amtundu wa aminoglycosides, komanso odwala omwe ali ndi vuto la impso, chifukwa chiopsezo cha zotsatira za poizoni wa aminoglycosides chikukula.

Kugwiritsidwa ntchito kwa mankhwalawa kwa mankhwalawa matenda amtundu wa khungu kumayenderana ndi chiopsezo cha kugwidwa ndi matupi awo, omwe pafupipafupi ndi 1.4%. Chiwopsezo cha kukhudzidwa kwa ziwonjezero chimachulukirachulukira ndikuwonjezereka kwa nthawi yogwiritsa ntchito. Kutengeka kwamagulu kumawonedwa mu mosaamicin ndi aminoglycosides, monga neomycin ndi kanamycin.

Pochiza madera akuluakulu pakhungu, makamaka kwa nthawi yayitali kapena pamaso pa zilonda zapakhungu, mayamwidwe amtundu amatha kuchuluka. M'mikhalidwe imeneyi, makamaka ana, kusamala kuyenera kuchitidwa, popeza chiopsezo cha zotsatira zoyipa za glamicin chikuchuluka.

Chifukwa cha kupezeka kwa kutsekeka kwa minyewa mu aminoglycosides panthawi yodziwonetsa bwino, muyenera kusamala ndi odwala omwe ali ndi myasthenia, matenda a Parkinson ndi matenda ena omwe amatsutsana ndi kufooka kwa minofu, komanso kugwiritsa ntchito munthawi yomweyo mankhwala ena okhala ndi vuto la kutsekeka kwa mitsempha.

Chifukwa cha kupezeka kwa mafuta oyera mtima ofaka ndi parafini amadzimadzi, mafuta ophatikizira a glamicin angayambitse kuchepa kwa mphamvu yakuchepa kwa makondomu a latex, potero amachepetsa chitetezo cha iwo ogwiritsa ntchito. Izi ziyenera kuganiziridwa mukamagwiritsa ntchito mafuta a fungo la genamicin kapena maliseche.

Gwiritsani ntchito odwala okalamba kumafuna kusamala ndikuwunika kwa nthawi yake aimpso.

Kukopa pa kuyendetsa magalimoto ndi njira zina zowopsa. Chifukwa chakufuna kuyambika mukamagwiritsa ntchito mankhwalawa, chisamaliro chikuyenera kuyendetsedwa poyendetsa magalimoto komanso pochita zinthu zomwe zimafunikira kuti anthu azisamalira bwino.