Lozap kapena Losartan: zili bwino?

Hypertension imakhala yovuta kwambiri, pakakhala kuti palibe chithandizo choyenera nthawi zonse chimabweretsa chitukuko cha zovuta ndi zina zoyenderana. Ngakhale kuti aliyense tsopano akudziwa za matenda otere, ndipo ambiri mwa iwo adakumana nacho, odwala ambiri sazindikira kuwopsa kwa matenda awa. Ndi matenda oopsa apamwamba kwambiri, pakapita nthawi, zizindikiro zowonongeka zimawonekera:

• ziwiya zosiyanasiyana (zotupa zam'manja zimakhudzidwa,
• ziwalo zamkati, bongo),
• ziwalo (mwadzidzidzi myocardial necrosis ingachitike (coronary infarction),
• minofu ya muubongo (minyewa yamtundu uliwonse),
• retina (zotupa zowonjezera mu fundus zomwe zimatsogolera kuwonongeka kwamaso kapena khungu lathunthu).

Pharmacology yamakono nthawi zonse imapereka mankhwala atsopano ambiri omwe angathandize odwala, koma ngakhale ndi mitundu yosiyanasiyana ya mankhwala, kusankha kwa pharmacotherapy okwanira nthawi zina kumatha kukhala ntchito yovuta kwa dokotala.

Zambiri pazamankhwala Losartan

Losartan ndi mankhwala othandizira kwambiri othandizira omwe amatha kuthana ndi kuthamanga kwa magazi mwakutseka mtundu wachiwiri wa receptor wa angiotensin. Chifukwa chakuchepa kwambiri kwa katundu kumanja ndi kumanzere kwa mtima, chida ichi sichimangolimbana ndi matenda oopsa, komanso chimachepetsa kupitilira kwa mtima wogwira ntchito.

Mankhwala amapezeka mu mawonekedwe a mapiritsi omwe amamwa pakamwa. Nthawi zambiri, madokotala amaphatikiza ndi mankhwala ena a mtima. Mlingo wofunikira umasankhidwa poganizira kuchuluka kwa magazi. Kukhazikitsidwa kwa mapiritsi kumayamba ndi milingo yochepa, pang'onopang'ono kuwonjezera ndende ngati kuli kotheka.

Mavuto omwe amapezeka kwambiri polandirira ndi:

• chizungulire
• kukomoka (chifukwa cha kuchepa kwambiri kwa kuthamanga kwa magazi),
• thupi lawo siligwirizana.

Analogs ndi choloweza

Losartan ndi mankhwala wamba a antihypertensive, omwe amaperekedwa kwa odwala ambiri amtima. Zomwe zimachitika chifukwa mankhwalawa pazifukwa zina sizinayenere, ndizosowa. Komabe, ngati izi zidachitika, ndiye kuti nthawi zambiri kulibe mavuto posankha munthu wogwirizira, popeza msika wamakono wamankhwala umatipatsa mitundu yambiri ya mankhwala oyenera kuthana ndi kuthamanga kwa magazi ndi zizindikiro zomwe zimachitika ndi matenda awa.

Otsatira angasankhidwe ku gulu lomweli (angiotensin receptor blockers), koma izi sizoyenera kuchita, chifukwa nthawi zambiri kutsutsana ndi mankhwalawa kumakhalapo kwa onse oimira gulu linalake. Analogue iyenera kusankhidwa poganizira zomwe wodwalayo atazindikira pazomwe zidayambitsa kuzimitsa kwa njira zomwe zidalipo kale.

Ngati mankhwalawo sanakwaniritse, ma fanizo ake amuchotseredwa pamodzi ndi dokotala. N`zosatheka kusintha mankhwalawa, mankhwala kapena mankhwalawa mosadalira, chifukwa izi zimapangitsa kuti pakhale zovuta zina zovuta paumoyo. Kumbukirani kuti aliyense wogwiritsa ntchito mankhwala ali ndi mndandanda wazomwe akuwonetsa ndi zotsutsana, makamaka mlingo ndi kulandira, zomwe zimayenera kuganiziridwa pokhapokha ndi njira yolumikizirana komanso pazochitika zina ndi zofunikira.

Lorista kapena Losartan: zomwe zili bwino

Lorista ndi analogue yopanga Chisiloveniya yomwe ili ndi mawonekedwe ofanana amtundu wa zamankhwala, chifukwa chinthu chofunikira kwambiri cha mankhwalawa ndi potaziyamu losartan. Zizindikiro za mankhwalawa ndizofanana ndi Losartan. Monga mwayi kwa Lorista, titha kuunikira kuti ali ndi mitundu yowonjezera yotulutsidwa yomwe nthawi yomweyo imakhala ndi hypothiazide diuretic (mankhwalawa amatchedwa Lorista N ndi Lorista ND). Izi zitha kukhala zenizeni kwa odwala omwe akuwonetsedwa kugwiritsa ntchito nthawi yomweyo antihypertensive ndi okodzetsa othandizira. Mankhwalawa onse amafuna kusintha kwa mlingo kwa odwala azaka zopitilira 70. Lorista imalekanitsidwa mwa anthu omwe ali ndi matenda a impso ndi chiwindi omwe amachititsa kuti ziwalo izi zisathe.

Lorista ndiokwera mtengo kwambiri, koma zosiyana sizili zazikulu kotero kuti zitha kudaliridwa mukamasankha mankhwala.

Lozap kapena Losartan: zomwe angasankhe

Lozap ili ndi maubwino angapo, popeza kapangidwe kake ndizotsogola. Chofunikira chachikulu pa mitundu yonse iwiriyi ndi mankhwala a potaziyamu losartan, omwe ali m'gulu la angiotensin receptor inhibitors amtundu wachiwiri. Koma Lozap kuwonjezera imaphatikizanso diuretic (hydrochlorothiazide), yomwe imathandizanso kutsitsa magazi, chifukwa chakuchepa kwa kuchuluka kwa magazi ozungulira.

Makhalidwe oyerekeza a Telmisartan ndi Losartan

Telmisartan ilinso ya gulu la angiotensin receptor antagonists. Zowona kuti mankhwalawa onse ali m'gulu lomwelo zimapangitsa kufanana kwawo. Telmisartan ikhoza kuperekedwa kwa onse pulayimale ndi yachiwiri matenda oopsa. Koma cholinga chake chikuyenera kupewedwa ngati wodwalayo ali ndi matenda opatsirana a mtima, hepatocellular ndi / kapena aimpso kulephera. Ndi chisamaliro chapadera komanso kuyang'aniridwa ndi apadera achipatala, mankhwalawa amaperekedwa kwa ana ndi achinyamata.

Telmisartan sayenera kugwiritsidwa ntchito pa nthawi yapakati chifukwa imakhala ndi vuto la mwana wosabadwayo ndi mluza.

Enalapril monga analogue

Enalapril ndi wa gulu la otsutsa a angiotensin otembenuza enzyme, chifukwa chake mankhwalawa, mwa njira ina, amazindikira momwe achire amathandizira. Zotsatira zake, enalapril imachepetsanso kupanikizana kwathunthu chifukwa cha kuphatikizika kwa vasodilation, pomwe kuchuluka kwa magazi ndi zochita za mtima sizisintha. Kuphatikiza apo, enalapril amadziwika ndi zotsatira zamtima, zomwe ndizofunikira pofikira odwala omwe ali ndi matenda a mtima.

Enalapril, ngati nthumwi zonse za ACE zoletsa, ali ndi zotsatira zosasangalatsa monga kukhazikitsa chifuwa chowuma, chopweteka. Koma losartan sizimabweretsa zovuta.

Valz kapena Losartan: zomwe zili bwino

Chofunikira chachikulu cha Valza ndi valsartan, omwe ali m'gulu la angiotensin receptor antagonists a mtundu wachiwiri. Ili ndi tanthauzo lotsogola, ngakhale osachita chilichonse chokhudzana ndi ntchito ya mtima (sasintha mphamvu ndi mafotokozedwe a mtima). Amagwiritsidwa ntchito kwa odwala omwe amafuna kuphatikiza mankhwala.

Pali mawonekedwe otulutsidwa otchedwa Valz N, omwe kuphatikiza pa valsartan mulinso ndi thiazide diuretic. Potere, kupanikizika kumachepetsa osati chifukwa cha vasodilation, komanso chifukwa chakuchepa kwa kuchuluka kwa njira yoyendayenda.

Edarby ngati cholowa m'malo mwa Losartan

Edarbi alinso m'gulu la angiotensin receptor blockers ndipo amachepetsa kupanikizika pochotsa ma vasoconstrictor zotsatira za angiotensin, minofu yosalala ya minofu yomwe ili mkati mwa khoma lamitsempha. Mankhwalawa amapangidwa ku Japan.

Muyenera kumwa Edabri kamodzi patsiku (m'mawa), zomwe zimathandizira kwambiri chithandizo cha odwala ndikuwonjezera kutsatira kwawo. Ndiosavuta kusankha mlingo woyenera wa wodwalayo, komabe, muyenera kukumbukira kuti muukalamba chizolowezi cha hypotonic chimawonjezeka, chifukwa chake muyenera kuyamba kupatsa mankhwalawa ndi kuperewera kwa zinthu zomwe zimagwira. Mwambiri, Edabri akhoza kukhala analogue woyenera.

Cozaar ndi Losartan: Makhalidwe Oyerekeza

Cozaar ndi mankhwala opangidwa ku Netherlands omwe chophatikiza chake chachikulu ndi losartan potaziyamu. Zotsatira zochizira pamthupi ndizofanana kwa Cozaar ndi Losartan. Kafukufuku yemwe angatsimikizire motsimikiza kuti ndi iti mwa mankhwalawa omwe ndi othandiza kwambiri omwe sanachitike. Pochita izi, mankhwala onse awiri atsimikizira kuti ndi othandiza komanso otetezeka.

Zofanizira zina

Pali ma analogi ambiri omwe amapangidwa kunja. Ambiri mwa mankhwalawa ali ndi mtengo wokwera, koma mankhwalawa adziwonetsanso kuti ali apamwamba komanso otetezeka. Uwu ndi mndandanda wazofanizira za mankhwala omwe amapangidwa kunja kwa dziko lathu:

• Losartan Teva - mankhwala opangidwa ku Hungary,
• Presartan, wopangidwa ku India,
• Lorista (wolima dziko la Slovenia),
• Lozap - mankhwala aku Czech,
• American Cozaar
• Azilsartan opangidwa ku Japan
• Telzap (dziko la Turkey),
• French Noliprel.

Zofanana ndi nyimbo

Mankhwala onsewa amapezeka piritsi. Nyimbo zomwe ndimankhwala ndimofanana, chifukwa zimakhala ndi zomwe zimagwira - potaziyamu losartan. Zothandiza zothandizanso ndizofanana: magnesium stearate, silicon dioxide, macrogol (chinthu chomwe chimapereka mankhwala ofewetsa thukuta), utoto woyera, lactose monohydrate.

Popeza kuti gawo lalikulu la mankhwalawa onse ndiofanana, mawonekedwe ake ogwiritsira ntchito samasiyana:

• matenda oopsa
• kulephera kwamtima,
• matenda ashuga nephropathy,
• lamanzere lamitsempha lamanzere,
• Hyperkalemia (pankhani iyi, mankhwala amaikidwa ngati amphamvu okodzetsa),
• Monga prophylaxis yochepetsera zoopsa zamatenda ndi pathologies a minofu ya mtima komanso mtima wam'maso pamaso pazinthu zopsetsa mtima.

Zotsatira za Lozap ndi Lozartan m'thupi nazonso - chinthu chachikulu chimathandizira kuonda magazi, mwakutero kuchepetsa chiopsezo cha kuundana kwa magazi. Kuchepetsa losartan potaziyamu kuchuluka kwa mahomoni aldosterone ndi norepinephrine, omwe, ndikamasulidwa kwambiri m'magazi, amakhudza mitsempha ya magazi, kutsitsa lumen pakati pawo. Iwo ali ndi kutchulidwa okodzetsa.

Mankhwala amathandizira kukhazikika kwa urea, kuthamanga kwa magazi, kusintha momwe zimakhalira ndikuthandizira kuchepetsa minofu ya mtima ndi mtima, yomwe ndi imodzi mwazabwino kwambiri pamatenda a mtima ndi mtima. Mankhwala osokoneza bongo alibe vuto lililonse lamkati lamanjenje. Zotsatira zakuchuluka kwa mahomoni achilengedwe norepinephrine, omwe amachepetsa lumen pakati pama khoma amitsempha yamagazi, amakhala osakhalitsa m'mankhwala.

Kusiyana pakati pa Lozap ndi Lozartan

Ngakhale kuti mankhwalawa onse ali ndi chinthu chimodzi chothandizira komanso mndandanda wofanana wazinthu zothandizira, pali kusiyana pakati pawo.

Ku Losartan, pali zinthu zina zowonjezera, motero mwayi wa zizindikiro zam'mbali ndi chiwonetsero chotsutsana ndizowonjezereka. Zowonjezera zina za Lozap ndi:

• magnesium wakuba,
• lactose monohydrate,
• calcium carbonate
• kukhuthala.

Mphamvu ya okodzetsa ya Lozap imaperekedwa ndi mankhwala mannitol, ndipo kukonzekera kwachiwiri - magnesium stearate. Chifukwa cha kukhalapo kwa mannitol mu mankhwalawa, Lozap amaletsedwa mwamphamvu kumwa nthawi yomweyo ndimankhwala omwe ali ndi diuretic. Kuphatikiza apo, kuyesedwa kwa labotale kuyenera kuchitika pafupipafupi nthawi yonse ya chithandizo kuti muwone ngati calcium ndi kuchuluka kwa mchere wamchere.

Mankhwala osokoneza bongo amakhalanso osiyana ndi opanga: Lozap ikupezeka ku Czech Republic, Lozartan - ku Israel, koma pali njira inanso yowonjezera yomwe Belarus imapanga.

Nthawi ya kuyambika kwa chithandizo chamankhwala imasiyana m'makampani. Lozapan imayamba kugwira ntchito mkati mwa maola 2-3, zotsatira zake zimakhala masiku 1-1.5, Lozartan - kuchokera maola 5 ndikusungidwa kwa chithandizo chamankhwala masana. Manambalawa ndiwambiri, chifukwa mphamvu ya mankhwalawa imatengera umunthu wa thupi lawo komanso kuopsa kwa vuto la wodwalayo, kuuma kwake komanso kulimba kwa chithunzi chake.

Kuopsa kwa zomwe zimachitika komanso mtundu wa zizindikiro zammbali ndizosiyana pakakonzedwe, komwe kumakhudzana ndi kusiyana kwa zomwe zikupezeka.

Contraindication

Losartan aletsedwa kutenga milandu zotsatirazi:

• kusalolera payekhapayekha,
• Mimba, kuyamwa,
• kulephera kwambiri kwa chiwindi
• zaka malire - mpaka zaka 6.

Contraindations pakusankhidwa kwa Lozap:

• thupi siligwirizana ndi gawo likulu kapena zoperekera zikuchokera,
• Kwambiri chizindikiro cha chiwindi kukanika
• mimba
• nthawi yoyamwitsa,
• zaka malire - mpaka zaka 18 (palibe deta pa zomwe zimachitika ndi mankhwala pakhungu la mwana).

Ndi zoletsedwa kotheratu kumwa onse mankhwalawa pogwiritsa ntchito mankhwala okhala ndi aliskiren (mosasamala kanthu za kupsinjika kwake) ndi ACE inhibitors.

Kodi kutenga Lozap ndi Losartan?

Mapiritsi amatengedwa pakamwa, ngakhale chakudyacho. Mlingo wochizira Lozap:

1. Matenda oopsa a arterial - ndikofunikira kuyamba mankhwalawa osachepera 50 mg (piritsi limodzi la 50 mg yothandizira kapena piritsi 100 mg). Kuti mukwaniritse zotsatira zabwino, mulingo ungathe kuwonjezeka pang'onopang'ono mpaka 100 mg patsiku. Kuchuluka kwa mankhwalawa ndizokwanira zomwe ziloledwa.
2. Odwala azaka zapakati pa 75 ndi kuposerapo (kuphatikiza ndi zodwala mu chithokomiro cha chithokomiro) - mlingo umachepetsedwa mpaka 25 mg kapena piritsi la 50 mg.
3. Monga prophylactic yoletsa mtima ndi mtima matenda - 50 mg patsiku.
4. Nephropathy mwa anthu odwala matenda ashuga ndi 50 mg patsiku. Pambuyo pa milungu ingapo ya maphunzirowa, mlingo umalimbikitsidwa kuti uwonjezeke mpaka 100 mg.

Malangizo ogwiritsira ntchito losperan ndi Mlingo, kutengera chikhalidwe, ndizofanana ndi kugwiritsa ntchito koyamba kwa mankhwala.

Zotsatira zoyipa za Lozap ndi Lozartan

Zotsatira zoyipa za thupi ku makonzedwe a losartan:

• pafupipafupi chizindikiro: chizungulire ndi kugona,
• dongosolo la lymphatic: kuchepa magazi,
• matenda amisala: kukhumudwa,
• dongosolo lamkati lamanjenje: kugona ndi kusowa chidwi, mutu ndi chizungulire, migraines,
• chitetezo chamthupi: anaphylactic reaction,
• kupuma kwamatenda: chifuwa chowuma, kufupika,
• khungu: kuyabwa ndi redness, urticaria,
• ziwalo zam'mimba: kupweteka pamimba, nseru, kusanza kwambiri, kutsekula m'mimba,
• kubereka: kusabala, kusokonekera kwa erectile.

Zotsatira zoyipa zomwe zingachitike pogwiritsa ntchito Lozap:

• magazi ndi zamitsempha yamagazi: kuchepa kwa magazi, kuchepa kwa magazi kwambiri,
• chitetezo chamthupi: Edema ya Quincke, ziwengo, zosowa kwambiri - kugwedezeka kwa anaphylactic,
• psyche: kukhumudwa,
• pakati mantha dongosolo: migraine, kusintha kukoma, kugona, chizungulire, kugona,
• masomphenya ndi makutu: vertigo, gubu m'makutu,
• mtima: syncope, angina pectoris, zosowa kwambiri: kusokonezeka kwa magazi mu ubongo,
• mtima dongosolo: kutsitsa magazi,
• kupumira: kufupika,
• zam'mimba dongosolo: nseru ndi kusanza, kutsegula m'mimba, matumbo kutsekeka, kupweteka m'mimba ndi m'mimba,
• chiwindi: chiwindi, kapamba,
• khungu: kuyabwa, urticaria.

Mankhwala osokoneza bongo a Losartan ndi Lozap amatha kukhala ndi chizungulire komanso tachycardia, kutsika magazi, kukomoka, ndi kugwa. Pankhani ya kugwiritsidwa ntchito kamodzi kwa mlingo waukulu wa mankhwalawa ndikuwonetsa zotsatira zoyipa, mankhwala amathandizira.

Thandizo loyamba - gonani wozunzidwa kumbuyo kwake, kwezani miyendo. Ngati ndi kotheka, yambitsani yankho la 0.9% sodium chloride. Mankhwala amathandizidwa kuti athandize odwala kupewetsa mavuto am'mbali ndi kuchepetsa matenda. Njira zolimbikitsidwa - chapamimba cham'mimba, mowa wambiri. Pambuyo kukhazikika kwa mkhalidwe wa wodwalayo, ndikofunikira kukhazikitsa kuwongolera pazizindikiro zazikulu za ntchito yofunika, ngati kupatuka, kumapangitsa kusintha kwachipatala.

Madokotala amafufuza

Andrei, wazaka 35, wazachipatala, Magnitogorsk: "Titha kunena kuti awa ndi mankhwalawa 2 okhala ndi mayina osiyanasiyana. Amathandizanso chimodzimodzi pakuthandizira komanso kupewa matenda amitsempha, koma ali ndi vuto limodzi - zotsatira zabwino kuchokera kugwiritsidwa ntchito kwawo ndizotheka pokhapokha ngati alipo kwa nthawi yayitali, ngati njira yoyendetsera yayifupi kapena kusokonezedwa pasadakhale, sizithandiza. Zomwe zikutanthauza kusankha ngati ali ofanana ndi nkhani ya kusankha kwa wodwalayo. ”

Svetlana, wazaka 58, wasayansi yamtima, Ulyanovsk: "Palibe kusiyana pakati pa mankhwalawa. Posankha mankhwala, munthu ayenera kuganizira za kupezeka kwa tsankho kwa zigawo zothandiza za wodwala. Ngati palibe zotsutsana, mungasankhe mankhwala malinga ndi mtengo wake. ”

Ndemanga za Odwala

Marina, wazaka 48, Kursk: "Dotolo adatumiza Lozapan kuyambira pachiyambi, koma ndidaganiza zogula Lozartan, chifukwa mtengo wake umakhala wotsika, ndipo wazamankhwala wazachipatala adamuwuza kuti anali wogwira ntchito kuposa woyamba. Koma, monga momwe zawonera, sizofanana ndendende, chifukwa sindinaphunzire zozizwitsa kuchokera kwa iwo, ndipo ngakhale patatha milungu yochepa ziwengo zinayamba kuonekera. Ndinasinthira ku Lozap yodula kwambiri, yomwe ndimalekerera bwino, palibenso zovuta zina komanso zovuta zina. ”

Cyril, wazaka 39, Ivanovo: "Poyamba ndinatenga Lozap, kuti ndisunge ndalama, chifukwa maphunzirowa anali a nthawi yayitali, ndinatembenukira kwa Lozartan. Sindinamvepo kusiyana kulikonse ndikusintha mankhwalawa. Ndinaganiza kuti sindiyenera kulipira ndalama zambiri ngati mankhwalawa amathandizanso komanso kulekerera bwino, sindinakhale ndi vuto lililonse. ”

Oksana, wazaka 51, ku Kiev: “Nkhani yanga ya momwe ndidaganizira kuti mtengo wake ndi wokwera mtengo, ndiye ndidagula Lozap m'malo mwa Lozartan. Anathandizanso, koma anayamba kuyambitsa nseru, chizungulire, komanso totupa pakhungu. Dokotala atamuuza Lozartan, yemwe chifukwa cha mtengo wotsika kwambiri sindinadalire poyamba, ndinalibe zotsatirapo zake. Ndipo zinkawoneka kuti ndizothandiza kuposa Lozap. ”

Mtengo wa mapiritsi a Lozap okhala ndi kuchuluka kwa zinthu zomwe zikugwira ndi 12.5 mg (paketi ya ma 30 pc.) - kuchokera ku ruble 230 mpaka 300, mtengo wa Losartan wokhala ndi mikhalidwe yomweyo - kuchokera ku 80 mpaka ma ruble 80.

Makhalidwe a Lozap

Awa ndi antihypertensive wothandizila kuchokera pagulu la angiotensin II receptor antagonists, omwe adapangidwa kuti achepetse kupsinjika ndikuwusunga munthawi yofananira. Amapezeka piritsi. The yogwira ndi losartan potaziyamu. Achire zotsatira za mankhwala umalimbana kupanikiza ntchito ya ACE, yomwe imatembenuza angiotensin I kukhala angiotensin II - chinthu chomwe chimapangika m'mitsempha yamagazi, yomwe imawonjezera kuthamanga kwa magazi.

Kuletsa angiotensin II kumabweretsa vasodilation. Izi zimathandiza kuti muchepetse kukakamizidwa kapena kuti kumakhalabe kozungulira.

Zotsatira zakumwa za mankhwalawa zimawonedwa pambuyo pa maola 1-1,5 ndipo zimapitilira tsiku lonse. Kuphatikizika kwakukulu kwa metabolite kumawonedwa pambuyo pa maola atatu. Kuti mupeze zotsatira zosatha, mankhwalawa amayenera kutengedwa masabata 4-5. Chifukwa cha kukulira kwa mitsempha yamagazi, ntchito ya mtima imayendetsedwa, yomwe imalola anthu omwe ali ndi matenda osokoneza mtima kuti athe kulolera bwino kupsinjika kwamalingaliro ndi thupi. Lozap amawonetsa kugwira ntchito mosamala ngati atengedwa ndi achinyamata achinyamata ndi anthu achikulire omwe ali ndi vuto loopsa la matenda oopsa.

Kumwa mankhwalawa kumatha kusintha kuchuluka kwa magazi aimpso komanso kutsekeka kwa mtima, chifukwa chake mankhwalawa amagwiritsidwa ntchito pochiza matenda a shuga ndi matenda a mtima. Imakhala ndi mphamvu yokhudza kukodzetsa thupi, chifukwa chamomwe madzi amachotsedwa m'thupi ndipo kutupa kumatetezeka.

Zisonyezero zogwiritsidwa ntchito:

• ochepa matenda oopsa
• matenda ashuga nephropathy okhala ndi proteinuria ndi hypercreatininemia odwala matenda amitundu 2, omwe amakhala ndi matenda oopsa.
• monga gawo la chithandizo chovuta cha matenda a mtima osalephera,
• Kuchepetsa chiopsezo cha matenda amtima (stroke, etc.) ndikuchepetsa kufa kwa anthu omwe ali ndi vuto lamanzere lamitsempha yamagazi.

Contraindations akuphatikiza:

• kumva kwambiri pazogulitsa,
• wazaka 18
• mimba
• nthawi yoyamwitsa,
• kukanika kwambiri kwa chiwindi,
• Anuria
• kulephera kwa aimpso.

Contraindication Lozap imaphatikizira: kukhudzidwa kwambiri ndi zigawo za mankhwala, zaka 18.

Kutenga Lozap kungayambitse kukulitsa zotsatirazi zoipa za thupi:

• anemia, eosinophilia, thrombocytopenia,
• Edema ya Quincke, photosensitivity, urticaria, zidzolo, pruritus, vasculitis,
• nkhawa, sciatica, chisokonezo, mantha, kupindika, kupindika, kupindika, migraine, kugona, kugona, kupweteka mutu, chizungulire, kupsinjika,
• tinnitus, mphamvu yoyaka m'maso, mawonekedwe osasinthika, vertigo, conjunctivitis, kuwonongeka kwa mawonekedwe, dysgeusia,
• palpitations, atrioventricular block ya degree yachiwiri, kugunda kwamtima, bradycardia, nosebleeds, hypotension, pachimake cerebrovascular ngozi, arrhythmia, kukomoka, angina pectoris,
• kutsokomola, kukomoka, kupweteka pachifuwa, matenda ammimba, laryngitis, pharyngitis, sinusitis, rhinitis, kuchulukana kwamphuno, kufupika kwa mpweya,
• kupweteka kwam'mimba, mano, pakamwa, kukanika, chiwindi, kusanza, nseru, kudzimbidwa, kusanza, nseru, kudzimbidwa, kutsekula m'mimba, matumbo
• kupweteka kwa minofu ndi kuphatikizika, fibromyalgia, kukokana kwa minofu, kupweteka kwa mwendo ndi kumbuyo, kusweka kwa minofu,
• aimpso ntchito, nocturia, kwamikodzo matenda, kuchepa libido, kusabala, kulephera kwaimpso,
• kuchulukitsa kwa zotupa, kupweteka m'mawondo, kutupa kwa mafupa ndi nkhope, nyamakazi, makanda, thukuta kwambiri, khungu lowuma, malaise wamba, kufooka, asthenia.

Ngati bongo, bradycardia kapena tachycardia, komanso kwambiri hypotension, zimayamba.

Khalidwe la losartan

Awa ndi mankhwala osokoneza bongo. Amapezeka piritsi. Zomwe zimagwiritsidwa ntchito ndi potaziyamu losartan, komwe ndi njira yosankha yomwe imalepheretsa maselo a AT1 subtype zolumikizira zosiyanasiyana: mtima, impso, chiwindi, adrenal cortex, ubongo, zotupa za minofu yosalala, zomwe zimalepheretsa kukula kwa angiotensins II.

Mankhwalawa amathandizira pambuyo pa kupangika, kutsitsa magazi. Pambuyo pa tsiku, mphamvu ya mankhwalawa imachepetsedwa. Zotsatira zokhazikika zowonekera zimawonedwa pambuyo pa masabata 3-6 okhazikika a losartan. Odwala ochepa matenda oopsa, mankhwalawa amachepetsa proteinur, kuchuluka kwa immunoglobulin G ndi albin. Kuphatikiza apo, chigawo chogwira ntchito chimakhazikitsa zomwe urea zili m'madzi a m'magazi.

Zisonyezero zogwiritsidwa ntchito:

• ochepa matenda oopsa
• kulephera kwa mtima
• matenda ashuga nephropathy,
• chiopsezo cha matenda opatsirana a mtima, monga stroko.

Contraindations akuphatikiza:

• mimba
• nthawi yoyamwitsa,
• kumva kwambiri pazogulitsa,
• wazaka 18.

Zisonyezo ntchito losartan: ochepa matenda oopsa, matenda ashuga nephropathy.

Zotsatira zotsatilazi zingachitike mutatenga losartan:

• kupweteka m'mimba kapena peritoneum,
• chizungulire
• kukodza kupweteka, magazi mkodzo,
• kupuma movutikira
• kukhumudwa, chisokonezo,
• khungu
• thukuta lozizira, kuzizira, chikomokere,
• masomphenya osalala
• chikhodzodzo
• kusanza, kusanza,
• kukomoka mtima,
• mutu
• kulemera kwamiyendo
• kufooka
• mawu achipongwe
• kukokana
• kulakwira
• kulira kapena kutuluka kwa milomo, miyendo, manja,
• kudzimbidwa
• vasculitis, arrhythmias, kugunda kwamtima, bradycardia,
• kukomoka, kuda nkhawa.

Pankhani ya bongo, kupanikizika kumatha kuchepa, tachycardia, bradycardia imatha kukhazikika.

Zoyenera kusankha?

Madokotala amakhulupirira kuti mankhwalawa ali pafupifupi ofanana. Kapangidwe ka mankhwalawa pafupifupi kofanana. Chithandizo chophatikizika mu mankhwala onsewa ndi losartan potaziyamu.

Mankhwala onse awiriwa ali ndi zochitika zambiri, koma cholinga chawo chachikulu ndikuchepetsa kukakamiza. Popeza onsewa ali ndi vuto limodzi pochiza matenda oopsa, kuti amvetsetse kuti ndi yani yoyenera, kukambirana ndi katswiri wamtima kumakhala kofunikira.

Kusiyanitsa kwakukulu pakati pa mankhwalawa ndi mayina osiyanasiyana, makampani amitengo yamitengo ndi opanga. Malinga ndi mawonekedwe ena, kukonzekera ndi fanizo.

Amapezeka piritsi. Mtengo wa mankhwala oyamba umasinthasintha kuchokera ku 230 kuchokera ku ma ruble 300 phukusi lililonse (ma 30 ma PC.). Mtengo wachiwiri uli pafupi 80-120 ma ruble kuchuluka komweko.

Dziko loyambira Lozapa - Slovakia. Maiko opanga mankhwala achiwiri: Israeli, Russia, Belarus.

Zomwe zimagwiritsidwa ntchito ngati mankhwala oyerekeza ndi potaziyamu losartan.

Zisonyezero akugwiritsa ntchito: matenda oopsa, matenda obwera chifukwa cha kusowa kwa magazi, kuwonongeka kwamitsempha ngati vuto la matenda a shuga 2, chiopsezo cha matenda opatsirana. Kutulutsidwa kwa mankhwala ndi mankhwala okhwima.

Mphamvu yodalirika ya kumwa mankhwalawa imachitika pakadutsa masabata 3-6 kuyambira nthawi yoyamba chithandizo. Kukhazikika kwa zochita zawo kumawonedwa mkati mwa maola 5-6 ndipo akumva masana.

Ndi matenda oopsa, omwe ali ndi vuto, ndi bwino kugwiritsa ntchito mankhwala ophatikiza. Mwachitsanzo, Lozap Plus. Kuphatikiza pa gawo lokhazikika, lilinso ndi gawo monga hydrochlorothiazide. Chifukwa cha zomwe amachita, mphamvu yotenga imachitika mwachangu kwambiri, imatenga nthawi yayitali kwakanthawi.

Ngati tiyerekeza Lozap Plus ndi Lozartan, ndiye ndi chithandizo chamankhwala, kugwiritsa ntchito Lozap Plus kudzakhala kothandiza kwambiri, chifukwa kumachitika mwachangu komanso motalika.

Mndandanda wa Otsika Otsika

Mankhwala osokoneza bongo othamanga amayenera kumwedwa mosalekeza, chifukwa chithandizo cha tsiku lililonse chokha chomwe chimakupatsani mwayi wopewa kuthamanga magazi komanso kuthana ndi matenda oopsa. Izi zimazindikira kufunikira kwakanthawi mtengo wamankhwala omwe amaperekedwa chifukwa choti ndalama zomwe zimagwiritsidwa ntchito pogula zimakhala zosowa pamwezi. Chifukwa chake, posankha mankhwala ofunikira, adotolo sayenera kungoganiza za magwiritsidwe ntchito ndi chitetezo cha mapiritsi, komanso mtengo wake.

Mndandanda wazinthu zotsika mtengo kwambiri ku Losartan:

Mutha kupeza ndemanga zambiri za Losartan, chifukwa mankhwalawa amathandizidwa nthawi zambiri. Ambiri mwa mayankho ndi abwino, pali zambiri zomwe zikuwonetsa kuti odwala anasinthadi mankhwalawa kuchokera kwa zoletsa za angitensin-kutembenuza, chifukwa chomwe adayamba kuvutikira ngati chifuwa chowuma. Komabe, mutha kupezanso ndemanga zoyipa za kapangidwe ka zovuta pamankhwala, koma pali ndemanga zochepa kwambiri.

Kuyerekeza kwa Lozap ndi Lozartan

Mankhwalawa ndi mawonekedwe ofanana omwe amafanana ndi machitidwe a zochita. Amakhala ndi zinthu zomwe zimagwira - potaziyamu losartan, omwe ntchito zake ndizolepheretsa angiotensins, omwe amachititsa vasoconstriction komanso kuwonjezeka kwa kuthamanga kwa magazi (BP). Kusiyana kwakukulu komwe kumaganiziridwa nthawi yoikidwiratu ndizinthu zomwe zimaphatikizidwa pazomwe zimapangidwa, momwe zotsutsana ndi chiopsezo cha mavuto zimadalira.

Cholinga chachikulu cha mankhwalawa ndikuchepetsa magazi. Ntchito ya losartan potaziyamu ndikusokoneza njira yomwe imabwezeretsa ma electrolyte a impso, omwe amachititsa kuti chithokomiro cha chlorine ndi sodium chizioneka. Pogwiritsa ntchito hydrochlorothiazide yopangidwa ndi thupi, kuchuluka kwa aldosterone, renin imayatsidwa mu madzi am'magazi, ndipo potaziyamu imachulukitsidwa mu seramu. Njira zonse zomwe zimapitilira zimatsogolera, chomaliza, mpaka kuzowonetsa izi:

• kuthamanga kwa magazi kufanana
• katundu pamtima amachepa
• kukula kwakukuru kwa mtima kumabwerera kwawamba.

Pharmacological zochita za Lozap ndi Lozartan:

• zigawo zikuluzikulu za mankhwala zimatengedwa mosavuta ndi maselo am'mimba,
• kagayidwe amapezeka chiwindi,
• kuchuluka kwambiri m'magazi kumawonedwa pambuyo pa ola limodzi,
• mankhwalawa amachotsedwa mu mawonekedwe osasintha ndi mkodzo (35%) ndi bile (60%).

Zina zofananira:

• yogwira ya losartan potaziyamu siyitha kulowa mu GEF (malingaliridwe amitsempha yamagazi) kulowa mkati mwa dongosolo lamanjenje, kuteteza maselo abongo a ubongo ku poizoni.
• Zotsatira zake zamankhwala zikuwoneka kale mwezi umodzi.
• zotsatira zake zikupitilira kwa nthawi yayitali,
• Mlingo woyenera wambiri ndi 200 mg tsiku lililonse (muyezo zingapo).

Zotsatira zoyipa zomwe zimapezeka ndi mankhwala osokoneza bongo ndizambiri:

• kukula kwa matenda otsegula m'mimba (2% ya odwala),
• myopathy - matenda a connective minofu (1%),
• yafupika libido.

Zotsatira zoyipa zomwe zimachitika mukamatenga Losartan ndi Lozap zimaphatikizanso kukulira kwa m'mimba.

Kodi pali kusiyana kotani?

Kusiyana pakati pa mankhwala ndizochepa kwambiri kuposa kufanana, koma kuyenera kuganiziridwa posankha mankhwala.

Popeza Lozap imaphatikizapo mannitol diuretic, mawonekedwe otsatirawa ogwiritsira ntchito akuyenera kuwonedwa:

• sayenera kumwedwa molumikizana ndi othandizira ena okodzetsa,
• Pamaso pa mankhwala, muyenera kuchita kafukufuku wa ma laborator of zviratidzo za VEB (hydrolyte balance),
• munthawi ya chithandizo, ndikofunikira kuti muziwona pafupipafupi mchere wa potaziyamu.

Losartan ili ndi mitundu yambiri yowonjezera. Pachifukwa ichi, pali mwayi wambiri wowonetsera thupi lawo komanso:

• Mosiyana ndi Lozap, kusankhidwa ndikuwonetsedwa chithandizo chovuta kwambiri momwe mankhwala a diuretic amagwiritsidwira ntchito,
• Losartan ali ndi ma fanizo ambiri, pogwiritsa ntchito momwe amafunikira kuti aphunzire mwatsatanetsatane zosakaniza zina,
• Losartan ndi yotsika mtengo.

Kusiyanitsa mankhwala ndi wopanga. Lozap imapangidwa ndi Slovak Republic (kampani ya Zentiva), Lozartan ndi mankhwala a Vertex opanga opangira opanga (analogues amaperekedwa ndi Belarus, Poland, Hungary, India).

Zomwe zimakhala zotsika mtengo

• 30 ma PC 12,5 mg - 128 ma ruble.,
• 30 ma PC 50 mg - 273 rub.,
• Ma PC 60. 50 mg - 470 rub.,
• 30 ma PC 100 mg - 356 rub.,
• Ma PC 60. 100 mg - ma ruble 580.,
• Ma PC 90. 100 mg - 742 rub.

• 30 ma PC 25 mg - 78 rub.,
• 30 ma PC 50 mg - 92 ma ruble.,
• Ma PC 60. 50 mg - 137 rub.,
• 30 ma PC 100 mg - 129 rub.,
• Ma PC 90. 100 mg - 384 rub.

Chingakhale bwino ndi lzap kapena losartan

Malinga ndi akatswiri, awa ndi mankhwalawa ofanana mu lingaliro la kuchitapo kanthu, osiyana mu mayina, mtengo ndi wopanga okha. Koma ayenera kumwedwa monga adanenera ndi adotolo, kuti asakuze mphamvu ya kufananirana ndi zina zothandizirana ndi zosakaniza zina. Zovuta zazikulu zimakhudzana ndi zowonjezera zowonjezera mphamvu. Pa upangiri wa Myasnikov A.L. (cardiologist), posankha antihypertensive mankhwala, ndikofunikira kuwongoleredwa ndi mulingo wa uric acid m'magazi. Ndi zochulukirapo zake komanso kugwiritsa ntchito mankhwala popanda diuretics, pamakhala chiopsezo cha arthrosis.

Kodi mankhwalawa ndi chiyani?

Chosakaniza chogwira ku Lozap ndi potaziyamu losartan. Mankhwalawa amapangidwa mwanjira ya mapiritsi atatu: 12,5, 50 ndi 100 mg. Izi zimathandiza wodwala kusankha njira yabwino kwambiri.

Lozap Plus ndichida chotsogola chophatikizika pang'ono. Muli mitundu iwiri yothandizira - losartan potaziyamu (50 mg) ndi hydrochlorothiazide (12.5 mg).

Zochita zamankhwala

Zomwe achire ake amapanga zimachepetsa kuthamanga kwa magazi, komanso kuchepetsa katundu pamtima. Izi zimaperekedwa ndi losartan, omwe ndi ACE inhibitor. Zimalepheretsa kupangika kwa angiotensin II, komwe kumayambitsa vasospasm komanso kuthamanga kwa magazi.. Chifukwa cha izi, ziwiya zimakula ndipo makoma awo amabwerera kamvekedwe kabwino, pomwe akuchepetsa kuthamanga kwa magazi. Zombo zouma zimaperekanso mpumulo kuchokera pansi pamtima. Nthawi yomweyo, pali kusinthika pakulekerera kwa kupsinjika kwa malingaliro ndi thupi kwa odwala omwe amalandira chithandizo chamankhwala awa.

Zotsatira zake atamwa mankhwalawa zimawonedwa pambuyo pa maola 1-2 ndipo zimatha tsiku limodzi. Komabe, kuti mukhalebe osasunthika pakadali pazovuta zina, ndikofunikira kumwa mankhwalawa kwa masabata atatu.

Zotsatira zonse zabwino za kutenga losartan zimatheka chifukwa cha kuwonjezeredwa kwa hydrochlorothiazide ku Lozapa Plus. Hydrochlorothiazide ndi diuretic yomwe imachotsa madzi ochulukirapo m'thupi, ndikuwonjezera mphamvu ya ACE inhibitor. Chifukwa chake, mankhwalawa akuwonetsa kutanthauzira kwakukulu chifukwa cha kukhalapo kwa zinthu ziwiri zogwira ntchito.

Zizindikiro zogwiritsidwa ntchito

Lozap ili ndi zotsatirazi zovomerezeka:

• matenda oopsa mwa akulu ndi ana azaka 6,
• matenda ashuga nephropathy,
• Kulephera kwamtima kosalekeza, makamaka kwa odwala okalamba, komanso kwa odwala omwe sioyenera ma inhibitors ena a ACE chifukwa cha zovuta zina.
• Kuchepetsa chiopsezo chokhala ndi matenda amtima komanso kuchepa kwa anthu omwe akudwala matenda oopsa.

Mankhwala okhala ndi hydrochlorothiazide pakapangidwe angagwiritsidwe ntchito pochiza:

• ochepa matenda oopsa mwa odwala omwe akuwonetsedwa pophatikiza chithandizo,
• ngati ndi kotheka, muchepetse chiopsezo chokhala ndi matenda amtima komanso kuchepetsa kufa kwa odwala matenda oopsa.

Zotsatira za pharmacological

Mankhwala a antihypertensive. Enieniotensin II wolandila wapadera (subtype AT1). Sizimaletsa kininase II, puloteni yomwe imathandizira kusintha kwa angiotensin I kukhala angiotensin II. Imachepetsa OPSS, kuchuluka kwa magazi a adrenaline ndi aldosterone, kuthamanga kwa magazi, kuthamanga kwa kufalikira kwa m'mapapo, kumachepetsa pambuyo pake, kumakhudzanso diuretic. Zimasokoneza kukula kwa hypertrophy ya myocardial, kumawonjezera kulolera kwa odwala omwe ali ndi vuto la mtima. Losartan sikuletsa ACE kininase II ndipo, motero, sikulepheretsa kuwonongeka kwa bradykinin, chifukwa chake, zotsatira zoyipa zomwe zimagwirizanitsidwa ndi bradykinin (mwachitsanzo, angioedema) ndizosowa kwenikweni.

Odwala omwe ali ndi matenda oopsa osaneneka a shuga ogwirizana ndi proteinuria (oposa 2 g / tsiku), kugwiritsa ntchito mankhwalawa kumachepetsa proteinuria, kuchuluka kwa albumin ndi immunoglobulins G.

Imakhazikika pamlingo wa urea m'madzi am'magazi. Sichikukhudzana ndi mawonekedwe akumasamba ndipo siyikhala ndi mphamvu yayitali pakulimbikitsidwa kwa norepinephrine mu plasma yamagazi. Losartan pa mlingo wofika mpaka 150 mg pa tsiku sizikhudza kuchuluka kwa triglycerides, cholesterol yathunthu ndi cholesterol ya HDL mu seramu yamagazi mwa odwala omwe ali ndi matenda oopsa. Pa mlingo womwewo, losartan sichikhudzana ndi kusala kwamwazi wamagazi.

Pambuyo pakamwa kamodzi, mphamvu ya hypotensive (systolic ndi diastolic magazi imatsika) imafika pazowonjezera pambuyo pa maola 6, kenako amayamba kuchepa mkati mwa maola 24.

Kuzindikira kwakukulu kumayamba masabata 3-6 pambuyo pa kuyamba kwa mankhwalawa.

Pharmacokinetics

Ikamamwa, losartan imatengedwa bwino, ndipo imagwira metabolism panthawi "yoyamba" kudzera m'chiwindi ndi carboxylation ndi cytochrome CYP2C9 isoenzyme ndikupanga metabolite yogwira. Systemic bioavailability wa losartan pafupifupi 33%. Cmax ya losartan ndi yogwira metabolite imatheka mu seramu ya magazi pambuyo pafupifupi ola limodzi ndi maola 3-4 atatha kudya, motero. Kudya sikumakhudza bioavailability wa losartan.

Zoposa 99% za losartan ndipo metabolite yake yogwira imamangiriza mapuloteni a plasma, makamaka okhala ndi albumin. Vd losartan - 34 l. Losartan mothandizidwa samalowa mu BBB.

Pafupifupi 14% ya osapsa omwe amapatsidwa mankhwala mkati kapena pakamwa amasinthidwa kukhala metabolite yogwira.

Chilolezo cha plasma cha losartan ndi 600 ml / min, ndipo metabolite yogwira ndi 50 ml / min. Kuvomerezeka kwa impso kwa losartan ndi metabolite yake yogwira ndi 74 ml / min ndi 26 ml / min, motsatana. Mukamamwa, pafupifupi 4% ya mlingo womwe umatengedwa ndi impso yake osasinthika ndipo pafupifupi 6% imachotsedwa impso ndi mawonekedwe a metabolite yogwira. Losartan ndi metabolite yake yogwira imadziwika ndi ma linear pharmacokinetics atamwa pakamwa mpaka 200 mg.

Pambuyo pakamwa, plasma woipa wa losartan ndi yogwira metabolite amachepetsa motsimikiza ndi womaliza T1 / 2 wa losartan pafupifupi 2 maola, ndipo yogwira metabolite pafupifupi maola 6-9. Mukamamwa mankhwalawa mlingo wa 100 mg /, osatinso kapena metabolite wogwira amadzaza kwambiri magazi a m'magazi. Losartan ndi metabolites ake amuchotsa m'matumbo ndi impso. Ogwira ntchito zathanzi, atamwetsa 14C yokhala ndi isotope yolembedwa kuti losartan, pafupifupi 35% ya mapepala okhala ndi radio radio amapezeka mu mkodzo ndi 58% mu ndowe.

Pharmacokinetics mu milandu yapadera yamankhwala

Odwala omwe ali ndi vuto loledzeretsa makamaka matenda osokoneza bongo omwe anali oledzera anali maulendo 5, ndipo metabolite yogwira inali yokwanira nthawi 1,7 kuposa antchito odzipereka aamuna athanzi.

Ndi creatinine chilolezo choposa 10 ml / min, kuchuluka kwa losartan m'madzi a m'magazi sikusiyana ndi zomwe zimachitika mwachilengedwe. Odwala omwe amafunikira hemodialysis, AUC ndi yokwanira 2 times kuposa odwala omwe ali ndi vuto laimpso.

Palibe wolartan kapena metabolite wake wogwira ntchito samachotsedwa mthupi ndi hemodialysis.

Kuzungulira kwa losartan ndi metabolite yake yogwira m'magazi am'magazi okalamba omwe ali ndi vuto losakanikirana kwa matenda oopsa samasiyana kwambiri ndi zomwe matendawa amagwira kwa anyamata omwe ali ndi matenda oopsa.

Kuzungulira kwa plasma kwa losartan mwa azimayi omwe ali ndi matenda oopsa kwambiri kunthawi ziwiri kuposa momwe amagwiritsidwira ntchito amuna omwe ali ndi matenda oopsa. Kuzindikira kwa metabolite yogwira amuna ndi akazi sikusiyana. Kusiyana kwa pharmacokinetic sikofunikira mwakuthupi.

Mlingo ndi makonzedwe

Mankhwala amatengedwa pakamwa, ngakhale chakudyacho. Kuchulukitsa kuvomerezeka - 1 nthawi patsiku.

Ndi ochepa matenda oopsa, pafupifupi tsiku lililonse 50 mg. Nthawi zina, kuti mupeze njira yothandizira kwambiri, tsiku lililonse mlingo ungathe kuwonjezeka mpaka 100 mg mu 2 kapena 1 piritsi.

Mlingo woyamba wa odwala omwe ali ndi vuto la mtima nthawi zonse ndi 12,5 mg kamodzi patsiku. Monga lamulo, mlingo umakulitsidwa ndi gawo la sabata (i.e. 12.5 mg patsiku, 25 mg patsiku, 50 mg patsiku) kwa avareji yokwanira ya 50 mg 1 nthawi patsiku, kutengera kulekerera kwa mankhwalawa.

Popereka mankhwala kwa odwala omwe amalandira okodzetsa pamiyeso yambiri, mlingo woyambirira wa Lozap® uyenera kuchepetsedwa mpaka 25 mg kamodzi patsiku.

Kwa odwala okalamba, palibe chifukwa chosinthira mlingo.

Mukamapereka mankhwala kuti muchepetse vuto la matenda amtima (kuphatikizapo sitiroko) ndi kufa kwa odwala omwe ali ndi matenda oopsa ndipo otsala amitsempha yamagazi ochepa, mlingo woyamba ndi 50 mg patsiku. M'tsogolomu, mlingo wocheperako wa hydrochlorothiazide akhoza kuwonjezeredwa ndipo / kapena mlingo wa kukonzekera kwa Lozap® ukhoza kuwonjezeka mpaka 100 mg patsiku la Mlingo wa 1-2.

Kwa odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga omwe amakhala ndi proteinuria, mlingo woyambirira wa mankhwalawa ndi 50 mg kamodzi patsiku, mtsogolomo, mlingo umakulitsidwa mpaka 100 mg tsiku lililonse (poganizira kuchuluka kwa kuthamanga kwa magazi) mu Mlingo wa 1-2.

Odwala omwe ali ndi mbiri ya matenda a chiwindi, kuchepa madzi m'thupi, munthawi ya hemodialysis, komanso odwala omwe ali ndi zaka zopitilira 75, akulimbikitsidwa kuchepa kwa mankhwalawa - 25 mg (1/2 piritsi ya 50 mg) kamodzi patsiku.

Zotsatira zoyipa

Mukamagwiritsa ntchito losartan pochiza matenda oopsa pamagazi oyesedwa, pazotsatira zonse, zotsatira za chizungulire zomwe zimasiyana ndi placebo ndi oposa 1% (4.1% motsutsana ndi 2.4%).

Odwala amadalira orthostatic zochita za antihypertensive othandizira, pogwiritsa ntchito losartan adawonedwa osakwana 1% ya odwala.

Kutsimikiza kwamafupipafupi a zovuta: pafupipafupi (≥ 1/10), nthawi zambiri (> 1/100, ≤ 1/10), nthawi zina (≥ 1/1000, ≤ 1/100), kawirikawiri (≥ 1/10 000, ≤ 1 / 1000), kawirikawiri kwambiri (≤ 1/10 000, kuphatikiza mauthenga amodzi).

Zotsatira zoyipa zomwe zimachitika pafupipafupi 1%:

Mapiritsi a Cozaar ndi Lozap ndi oimira mankhwala a antihypertensive omwe amapangidwa kuti achepetse kuthamanga kwa magazi kapena kupewa "kudumpha" mwa anthu. Pakadali pano, ndalamazo zimadziwika kwambiri pakati pa odwala oopsa, chifukwa amachita zinthu mwachangu. Kuphatikiza apo, mtengo wa Cozaar ndi Lozap ndiwotsika kwambiri. Koma ndi iti mwa mankhwalawa omwe akadali abwino kwambiri pambali yake? Tiyeni timvetsetse mwakuwunikira kwazomwe zimachitika mu mankhwala ake komanso momwe zimagwirira ntchito.

Kuphatikizika, katundu ndi mawonekedwe a kumasula kwa Kozaar

Cozaar - mankhwala omwe ali ndi tanthauzo lotsogolera

Cozaar ndi mankhwala oopsa omwe amachepetsa kuthamanga kwa magazi a munthu ndipo amatha kupewetsa kusokonezeka. Kuchitanso chimodzimodzi kwa mankhwalawa kumatheka chifukwa chakuti, pakulowa m'thupi, chimalepheretsa maselo omwe amalimbikitsa kusakhazikika kwa magazi, chifukwa chomwe chitha kukwaniritsa mphamvu yayitali.

Pakadutsa kamodzi, Cozaar amagwira ntchito mwachangu mu maola 6-7, kenako mphamvu ya mankhwalawa m'thupi imayamba kuchepa. Mchitidwe wogwiritsa ntchito Cozaar mu mtima umawonetsa kuti zotsatira zazikulu kwambiri za mankhwalawa zitha kupezeka pogwiritsa ntchito maphunziro a sabata 3-4.

Malingaliro a kutenga Cozaar nthawi zambiri amawonjezeka. Kumayambiriro kwa maphunzirowa, mankhwalawa samapitirira mamiligalamu 25-50 a mankhwalawa patsiku, atatha milungu ingapo kumwa mankhwalawa, kupezeka kwa ma milligram 100 mpaka 100 patsiku amaloledwa. Mwachilengedwe, mulingo woyenera kwambiri umatsimikiziridwa ndi adotolo, chifukwa chake "ores "sayenera kuyesa pankhaniyi.

Zomwe zimapangidwira Cozaar zimaphatikizapo zinthu zingapo, monga:

• losartan potaziyamu (chinthu chachikulu)
• chimanga wowuma kukonza zinthu
• magnesium wakuba
• lactose
• sera ya carnauba
• Hyprolose ndi zina zingapo zothandizira

Njira yotulutsira mankhwalawa imaphatikizira mapiritsi okhala ndi zokutira zamafuta. Kutengera kuchuluka kwa mankhwala omwe amapezeka mu mankhwalawa, mitundu ya 50- ndi 100-milligram yamankhwala imapezeka. Phukusi lomwe lili ndi Cozaar ndi loyera, nthawi zambiri limakhala m'mbale iwiri ya mapiritsi 14 lililonse.

Kuphatikizidwa kwa malowa ndi mawonekedwe a Lozap

Lozap ndi mankhwala osokoneza bongo

Lozap, wofanana ndi amene takambirana pamwambapa ndi Cozaar, alinso mankhwala oopsa, komabe, amapangidwa pamodzi. Monga gawo la mankhwalawa, ziwiri zofunika:

Kuphatikiza pa kugwira ntchito kwa ma receptor omwe amachititsa kuti magazi azithamanga, ziwalo za Lozap zimakhudza mwachindunji kukana kwa mtima wama cell. Zotsatira zake, kuchuluka kwa zinthu zowonjezera mphamvu kumachepa m'magazi kuchokera "m'magawo" awiri nthawi imodzi. Kutalika kwa kuchitapo kanthu, njira zomwe mankhwalawa amamugwiritsa ntchito ndi mtundu wa mankhwala mothandizidwa ndi Lozap kwenikweni sizimasiyana ndi zomwe zimadziwika ndi Cozaar.

Lozap imapangidwa ndi piritsi lomweli. Mapiritsi amaikidwa m'matumba oikidwa mu zoyera mapaketi a 90 zidutswa chilichonse. Monga Cozaar, Lozap ikupezeka m'magawo 50- ndi 100-milligram malinga ndi zomwe zili pazinthu zazikulu. Mwakutero, ngakhale pano mankhwalawa ali, ngati safanana, ndiye ofanana kwambiri.

Zindikirani! Lozap ndi wokometsa wokongola kwambiri.

Izi ndi chifukwa cha kupezeka kwa kapangidwe ka hydrochlorothiazide, komwe kumakhudza bwino kukana kwamitsempha yamagazi, koma kumachulukitsa kuchuluka kwa mapangidwe a mkodzo. Mwinanso mawonekedwe a Lozap amamu kusiyanitsa ndi wotsutsa masiku ano.

Kodi mankhwala amaikidwa liti?

Nthawi zambiri, mankhwalawa amapatsidwa mankhwala ochepa oopsa

Kukhazikitsidwa kwa Cozaar ndi Lozap kumachitika mu zamankhwala pochotsa matenda oopsa mwanjira iliyonse yowonetsera. Zizindikiro zoyenera kumwa mankhwalawa ndi:

1. nthawi zina matenda oopsa
2. IHD ya mapangidwe aliwonse, owonetsedwa ndi zizindikiro za kulephera kwa mtima
3. proteinuria
4. lamanzere lamitsempha lamanzere

Kuphatikiza pazofunikira zazikulu mthupi, zomwe zimapangitsa kuti magazi azichulukirachulukira, Cozaar ndi Lozap amathandizanso kuchepetsa zoopsa zomwe zimachitika panthawi yolimbitsa thupi. Chifukwa cha malowa, mankhwalawa omwe amafunsidwa nthawi zambiri amapatsidwa mankhwala ochepa kwa anthu omwe ali ndi vuto lotenga matenda oopsa, ndi cholinga chopewa masewera.

Monga lamulo, Cozaar ndi Lozap ndi amodzi mwa magawo a maphunziro athunthu a matenda a mtima, chifukwa chake, amapatsidwa udokotala wokhazikika. Chofunikira pakugwiritsa ntchito mankhwalawa ndikuwonjezera Mlingo wawo pang'onopang'ono mpaka kupanikizika kwambiri. Kupanda kutero, palibe zofunika kwambiri mu antihypertensive therapy.

Kodi iwo akupangidwira ndani?

Cozaar ndi Lozap ali ndi zotsutsana zofananira kuvomereza. Kunena zowona, tikukambirana zoletsa izi:

• ziwengo zosiyanasiyana za mankhwala
• lactose tsankho
• matenda oopsa a chiwindi
• zaka mpaka 16-18 zaka
• kuphatikiza kwa mankhwala ndi mankhwala "Aliskiren" ndi zina zotero
• mimba
• nyere

Ndi kulephera kwa aimpso, mankhwala amatha kumwa pokhapokha ngati akuwuzani dokotala!

Ku Lozap, mndandanda wa contraindication ndi wocheperako, chifukwa chake umathandizidwa ndi hyperuricemia, gout, hyponatremia, hypokalemia ndi hypercalcemia. Zoletsa zonse zolembedwa zimagwirizanitsidwa ndi katundu wa diuretic wa mankhwalawa, kotero kuiwala zaiwo ndikosavomerezeka.

Mosamala, Cozaar ndi Lozap ndizofunikira kwa anthu omwe akuvutika:

• mitundu yamphamvu yamtima arrhythmias
• mavuto a impso
• kuchuluka kwa magazi m'thupi
• ochepa hypotension
• kuyanʻanila mphamvu zamagetsi zamagetsi

Nthawi zina, kugwiritsa ntchito mankhwalawa ndikuloledwa.

Zotsatira zoyipa

Pogwiritsa ntchito molakwika mankhwala a antihypertensive kapena kunyalanyaza zolakwika zawo, mawonekedwe owoneka samakhala olakwika. Kwa Lozap, mndandanda wazotsatira zomwe zingachitike:

• hyperglycemia
• kufooka kowonjezereka
• kupweteka kwa minofu ndi mafupa
• kutupa kwa mucous nembanemba thupi
• mavuto am'mimba
• kukula kwa kusowa tulo
• kupweteka mutu komanso chizungulire

Zambiri kuchokera ku mankhwala a Lozap zitha kupezeka mu video6

Cozaar ali ndi zovuta zina zowonekeratu. Mndandanda wawo woyambira ndi:

• mavuto a chimbudzi
• kusachita bwino
• chiwopsezo cha edema (osati mwa mawu a mucous nembanemba)
• kupweteka kwa sternum
• nseru
• kutsegula m'mimba
• kukokana
• kusowa tulo komweko
• dyspepsia
• mawonekedwe a chifuwa champhamvu chosadziwika
• kuchuluka kwa matenda a impso ndi chiwindi
• Hyperpigmentation pakhungu
• kuyabwa

Mwachilengedwe, ndi mankhwala osokoneza bongo ambiri, mbali yayikulu yotsatsira ndikuchepa kwamphamvu kwa kuthamanga kwa magazi. Ngati chilichonse mwa zodziwikirazi chikuwoneka ndi pafupipafupi, Cozaar kapena Lozap ayenera kutayidwa, osafunsidwa kaye ndi adokotala. Zotsatira zoyipa zimatha kukhala zoopsa kwambiri, musaiwale za izi.

Chili bwino ndi chiyani - Cozaar kapena Lozap?

Mankhwala onse awiriwa amachepetsa kuthamanga kwa magazi.

Tsopano poti zofunikira zokhudzana ndi Cozaar ndi Lozap zaganiziridwa bwino, ndi nthawi yoti muyankhe funso lalikulu m'nkhani ya lero - "Ndi mankhwala ati ali bwino?".

Ambiri ayenera kukwiya, koma palibe yankho lenileni la funsoli. Zonse zimatengera momwe amagwiritsidwira ntchito mankhwala mwachitsanzo:

• Pankhani yothamanga komanso kulimba kwa ntchito, Lozap ndiyabwinoko, popeza imakhudza zolandilira pamtima dongosolo, komanso diuretic. Cozaar sangadzitame pa izi, ngakhale mankhwalawa amagwiranso ntchito nthawi imodzi, komanso moyenera.
• Ponena za zotsutsana ndi mtengo, Cozaar imawoneka yopindulitsa kwambiri, yomwe ndiyotsika mtengo ndipo ili ndi zoletsa zochepa pazakugwiritsa ntchito.
• Ngati titembenukira ku "zoyipa" zomwe zingatheke, ndiye kuti momwe zinthu ziliri, nzofanana. Ngakhale mndandanda wawo wonse, womwe ndi wa Cozaar, ndikofunikira kumvetsetsa kuti zoyipa ndizosowa, chifukwa chake siziyenera kutengedwa kwambiri. Komanso, ndikusankha komaliza kwa mankhwalawa.

Zomwe zili bwino kwa inu makamaka - Cozaar kapena Lozap, sankhani nokha. Zomwe timagwiritsa ntchito zimalepheretsa tokha kudzipatsa mankhwala a mtima, ndipo munthawi yamankhwala amalimbikitsa kuti nthawi zonse muzikambirana ndi akatswiri azachipatala.

Kusankhidwa kwa mankhwalawa chithandizo sichimasiyana pankhaniyi, chifukwa chake musanatenge Cozaar komanso musanagwiritse ntchito Lozap, onetsetsani kuti mukuyendera katswiri wa mtima. Njira iyi ndi yolondola kwambiri komanso ndi yotetezeka.

Chingalowe m'malo mankhwalawa ndi chiyani?

Kumapeto kwa nkhani ya lero, tiyeni tigwiritse ntchito fanizo labwino kwambiri la Cozaar ndi Lozap. Msika wamakono wa pharmacology umapereka zosankha zotsatirazi m'malo mwa mankhwalawa:

Musanatenge ndalama zilizonse pamwambapa, onetsetsani kuti mwawerengera malangizo omwe akubwera nawo. Mwina mndandanda wa contraindication, zotsatira zoyipa ndi zina zokhudzana ndi kumwa mankhwala ena ndizosiyana kwambiri ndi zomwe zikuganiziridwa lero.

Mwina iyi ndiye mfundo yofunika kwambiri pamutu wankhani yamasiku ano. Tikukhulupirira kuti zolembedwazo zinali zothandiza kwa inu ndipo zidayankha mafunso anu. Ndikufuna mukhale ndi thanzi labwino komanso chithandizo chodwala matenda onse!

Kodi mwazindikira kulakwitsa? Sankhani ndikusindikiza Ctrl + Lowanikutiuza.

Zochokera pa intaneti

Ndi mankhwala ati ali bwino: Lozap kapena Lorista? Mankhwalawa onse ali ndi machitidwe osiyanasiyana, koma cholinga chawo chachikulu ndikuchepetsa kuthamanga kwa magazi. Kuti muzindikire kusiyanasiyana pakati pa mankhwalawo, ndikuti ndi yani yothandiza kwambiri pochiza matenda oopsa, muyenera kuwerengera payokha malangizo a Lozapa ndi Lorista, komanso kuonana ndi katswiri kuti asankhe payekha kuchuluka kwa maphunzirowo ndikuwonetsa kutalika kwa maphunzirowo.

Kuyerekezera Mankhwala

Kuti mupange chisankho choyenera, muyenera kufananiza mawonekedwe a mankhwalawa.

Mankhwala onsewa amapezeka piritsi. Ali ndi zinthu zomwezi - yogwira potaziyamu - ndi zina zowonjezera: macrogol, silicon dioxide, magnesium stearate. Lozapan ndi Losartan ali ndi zofanana pakugwiritsa ntchito. Amakhala ndi vuto lofanana ndi thupi - amakulitsa mitsempha yamagazi, chifukwa chomwe kupanikizika kumachepa ndipo katundu pa mtima amachepa, zomwe ndizofunikira kupewa matenda monga kugwidwa ndi matenda a mtima.

Zotsatira zakuchuluka kwa norepinephrine (chinthu chamafuta), chomwe chimachepetsa lumen pakati pama khoma amitsempha yamagazi, sichikhazikika pakanthawi kochepa. Kuphatikiza apo, mankhwalawa onse amatha kuyambitsa mavuto ambiri.

Kupanga ndi kuchitapo kanthu

Mankhwala "Lorista" ndi "Lozap" ali ndi losowa monga chinthu chogwira ntchito. Zothandiza "Lorista":

• kukhuthala
• chakudya chowonjezera E572,
• CHIKWANGWANI
• cellulose
• chakudya chowonjezera E551.

Zowonjezera zamankhwala "Lozap" ndizothandiza motere:

• hypopellose,
• sodium croscarmellose,
• MCC
• povidone
• chakudya chowonjezera E572,
• mannitol.

Kuchita kwa chipangizo chachipatala cha Lozap kumalimbitsa kuchepetsa kuthamanga kwa magazi, zotumphukira zambiri zamitsempha yamagazi, kuchepetsa katundu pamtima, ndikuchotsa madzi ndi mkodzo wambiri mthupi ndi mkodzo. Mankhwalawa amaletsa myocardial hypertrophy ndikuwonjezera kupirira kwa anthu omwe ali ndi vuto la mtima. Lorista imalepheretsa zolandilira za AT II mu impso, mtima, ndi mitsempha yamagazi, zomwe zimathandizira kuchepetsa kuchepa kwa ma arterial lumen, OPSS yotsika, ndipo, chifukwa chake, kutsika kwa magazi.

Bweretsani ku zomwe zalembedwa

Zizindikiro ndi contraindication

Kukonzekera kochokera ku losartan kumalimbikitsidwa kuti mugwiritse ntchito pazotsatirazi:

Pa nthawi yoyembekezera, kugwiritsa ntchito mankhwala omwe ali ndi yogwira chimodzimodzi sikulimbikitsidwa.

Amalephera kugwiritsa ntchito mankhwala pokonzekera omwe amakhala ndi amayi omwe ali ndi ana oyamwitsa, ana osaposa zaka 18, komanso ndi njira zotsatirazi:

• kuthamanga kwa magazi
• kuchuluka kwa potaziyamu m'magazi,
• kusowa kwamadzi
• kusalolera pakumwa mankhwala,
• lactose tsankho.

Bweretsani ku zomwe zalembedwa

Zofananira zina

Ngati pazifukwa zina sizingatheke kugwiritsa ntchito "Lozap" ndi "Lorista", madokotala amapereka mayendedwe awo:

Mankhwala aliwonse, omwe ndi analogue a Lorista ndi Lozapa, ali ndi malangizo ake ogwiritsira ntchito, zomwe zikutanthauza kuti amayenera kumwedwa pokhapokha atakambirana ndi dokotala wazopanga yemwe amapereka chithandizo chamankhwala payekha kwa wodwala aliyense. Ndi chithandizo chodzilankhulira nokha, chiopsezo chokhala ndi mavuto amtsogolo chimakulanso.

Matenda oopsa a arterial asandulika vuto la pachaka la anthu ambiri. Chifukwa chake, mankhwala ambiri atsopano amapezeka chaka chilichonse kuti athane ndi matendawa. Njira imodzi yamakono ndi Lozap komanso mitundu yosiyanasiyana ya Lozap Plus.

Kodi mankhwalawa ndi chiyani?

Chosakaniza chogwira ku Lozap ndi potaziyamu losartan. Mankhwalawa amapangidwa mwanjira ya mapiritsi atatu: 12,5, 50 ndi 100 mg. Izi zimathandiza wodwala kusankha njira yabwino kwambiri.

Lozap Plus ndichida chotsogola chophatikizika pang'ono. Muli mitundu iwiri yothandizira - losartan potaziyamu (50 mg) ndi hydrochlorothiazide (12.5 mg).

Zomwe achire ake amapanga zimachepetsa kuthamanga kwa magazi, komanso kuchepetsa katundu pamtima. Izi zimaperekedwa ndi losartan, omwe ndi ACE inhibitor. Zimalepheretsa kupangika kwa angiotensin II, komwe kumayambitsa vasospasm komanso kuthamanga kwa magazi.. Chifukwa cha izi, ziwiya zimakula ndipo makoma awo amabwerera kamvekedwe kabwino, pomwe akuchepetsa kuthamanga kwa magazi. Zombo zouma zimaperekanso mpumulo kuchokera pansi pamtima. Nthawi yomweyo, pali kusinthika pakulekerera kwa kupsinjika kwa malingaliro ndi thupi kwa odwala omwe amalandira chithandizo chamankhwala awa.

Zotsatira zake atamwa mankhwalawa zimawonedwa pambuyo pa maola 1-2 ndipo zimatha tsiku limodzi. Komabe, kuti mukhalebe osasunthika pakadali pazovuta zina, ndikofunikira kumwa mankhwalawa kwa masabata atatu.

Zotsatira zonse zabwino za kutenga losartan zimatheka chifukwa cha kuwonjezeredwa kwa hydrochlorothiazide ku Lozapa Plus. Hydrochlorothiazide ndi diuretic yomwe imachotsa madzi ochulukirapo m'thupi, ndikuwonjezera mphamvu ya ACE inhibitor. Chifukwa chake, mankhwalawa akuwonetsa kutanthauzira kwakukulu chifukwa cha kukhalapo kwa zinthu ziwiri zogwira ntchito.

Zizindikiro zogwiritsidwa ntchito

Lozap ili ndi zotsatirazi zovomerezeka:

• matenda oopsa mwa akulu ndi ana azaka 6,
• matenda ashuga nephropathy,
• Kulephera kwamtima kosalekeza, makamaka kwa odwala okalamba, komanso kwa odwala omwe sioyenera ma inhibitors ena a ACE chifukwa cha zovuta zina.
• Kuchepetsa chiopsezo chokhala ndi matenda amtima komanso kuchepa kwa anthu omwe akudwala matenda oopsa.

Mankhwala okhala ndi hydrochlorothiazide pakapangidwe angagwiritsidwe ntchito pochiza:

• ochepa matenda oopsa mwa odwala omwe akuwonetsedwa pophatikiza chithandizo,
• ngati ndi kotheka, muchepetse chiopsezo chokhala ndi matenda amtima komanso kuchepetsa kufa kwa odwala matenda oopsa.

Momwe mungamwe mankhwala

Mankhwalawa amatha kuyambika atatha kufunsa dokotala. Kupatula apo, monga mankhwala onse, ali ndi zotsutsana, zoyipa ndi mawonekedwe ogwiritsira ntchito. Chifukwa chake, kudzipereka wekha kumatha kukhala koopsa komanso koopsa.

Mlingo wovomerezeka wa mankhwalawa umagwiritsidwa ntchito kamodzi patsiku, bwino kwambiri madzulo. Mapiritsi sangaphwanyidwe kapena kuphwanyidwa. Ayenera kumezedwa yonse, kutsukidwa ndi madzi okwanira. Njira ya mankhwalawa imalembedwa ndi adokotala, poganizira momwe mankhwalawa amathandizira komanso momwe wodwalayo alili.

Dokotala yekha ndi amene angalimbikitse kuti ndi mitundu iwiri iti ya Lozap yomwe ili bwino kwambiri. Itha kudziwidwa pokhapokha ngati pali zambiri zamapiritsi a Lozap Plus, komanso kugwiritsa ntchito kwake mosavuta. Inde, ngati mukusankhidwa kuti muphatikize mankhwala osakaniza, simumayenera kumwa mankhwala owonjezera, chifukwa amapezeka kale mu mankhwala.

Losartan anali woyamba mankhwala - woimira kalasi ya angiotensin-II receptor blockers. Idapangidwa kale mu 1988. Mankhwalawa adadziwika kalekale m'mayiko olankhula Russia. Kulembetsa ndikugulitsa pansi pa mayina:

Mapiritsi Akukakamiza: Mafunso ndi Mayankho

• Momwe mungapangire matenda a kuthamanga kwa magazi, shuga ndi mafuta m'thupi
• Mapiritsi oponderezedwa ndi adotolo amawagwiritsa ntchito kuthandiza bwino, koma tsopano afooka. Chifukwa chiyani?
• Zoyenera kuchita ngati ngakhale mapiritsi amphamvu kwambiri samachepetsa kupanikizika
• Zoyenera kuchita ngati mankhwala oopsa kwambiri
• Kuthamanga kwa magazi, vuto la kuthamanga kwa magazi - mawonekedwe a mankhwalawa achichepere, pakati komanso okalamba

Mapiritsi ophatikizidwa a losartan ndi okodzetsa a mankhwala a hypothiazide (dichlothiazide) amagulitsidwa pansi pa mayina:

• Gizaar
• Gizaar Forte
• Lorista N,
• Lorista ND,
• Lozap kuphatikiza.

Kuti mumve zambiri za kukonzekera kwa losartan komanso Mlingo womwe ulipo, onani tebulo "Angiotensin receptor antagonists omwe alembedwa ndikugwiritsidwa ntchito ku Russia" munkhani yayikulu "Angiotensin-II receptor blockers".

Mphamvu ya losartan yatsimikizika kwa odwala omwe ali ndi matenda oopsa osakanikirana ndi zina zowonjezera pazovuta:

• ukalamba
• lamanzere yamitsempha yamagazi yam'mitsempha,
• kulephera kwa mtima
• myocardial infaration
• mavuto a impso (nephropathy) chifukwa cha matenda ashuga kapena zifukwa zina.

Maphunziro azachipatala pa Kugwira Ntchito ndi Chitetezo ku Losartan