Kodi ma statins amayambitsa matenda a shuga?

Ma Statin, omwe nthawi zambiri amalembedwa kuti muchepetse cholesterol, amachulukitsa chiopsezo cha matenda a shuga 2 ndi 30%. Zotsatira za kuyesa kwaposachedwa kwadzetsa chidwi pa zokambirana mdziko la zamankhwala i.

Statin ndi amodzi mwa mankhwala odziwika bwino kwambiri ku USA. Kubwerera ku 2012, pafupifupi kotala ya anthu aku US opitilira 40 ndipo nthawi zambiri ankamwa mankhwala ochepetsa mafuta m'thupi, mu milandu yambiri - ma statins. Masiku ano, chiwerengerochi chakwera mpaka 28% (ngakhale atawerengedwa ku chiwerengero chokulirapo cha aku America).

Amachepetsa cholesterol yamagazi pochepetsa kupanga kwa chiwindi. Amalepheretsa enzyme hydroxymethylglutaryl-coenzyme A-reductase mmenemo, yomwe imakhudzidwa ndikupanga cholesterol.

Kuphatikiza apo, ma statins amachepetsa kutupa ndi oxidative nkhawa. Popeza zonsezi zimatengedwa pamodzi, wina angayembekezere kuti ma statins adzachepetsa chiopsezo cha matenda ashuga a mtundu 2.

Komabe, umboni wochokera ku kafukufuku ochulukirachulukira akusonyeza kusiyanitsa - kugwiritsa ntchito ma protein nthawi yayitali kumawonjezera chiopsezo cha matenda a shuga 2. Phunziro loyamba lotere lidasindikizidwa kale mu 2008. ii.

Poyankha izi, kafukufuku wambiri adachitika posachedwa, ndipo m'modzi wa (mu 2009) adati, malinga ndi momwe amapangira, palibe vuto lililonse lomwe limagwiritsidwa ntchito pakugwiritsa ntchito statin pachiwopsezo cha matenda a shuga motero maphunziro owonjezera anali ofunika iii, ndi ena (mu 2010 ) - kuti pali malo omwe angawonjezere chiopsezo cha matenda ashuga, koma kuti ndi ochepa kwambiri iv (kusagwirizana koteroko mu zotsatira kungafotokozedwe ndikuti maphunziro ena amathandizidwa ndi makampani opanga mankhwala okha - Wotanthauzira Womasulira).

Kuti mudziwe zenizeni zomwe zikuchitika, ofufuza ochokera ku Albert Einstein College of Medicine ku New York adaganiza zothanirana ndi nkhaniyi mwanjira ina ndikuyang'ana kwambiri anthu onenepa kwambiri, motero, ali ndi chiopsezo chotenga matenda a shuga. Gulu la asayansi linagwiritsa ntchito zidziwitso za boma kuchokera ku United States Diabetes Prevention Program (DPPOS). Mwambiri, kugwiritsa ntchito ma statins kwadzetsa chiwopsezo cha 36% pachiwopsezo cha matenda a shuga 2. Chifukwa chokha chomwe chimapangitsa kukayikira pamawonekedwe otetezeka kwambiri ndikuti ziwonetsero zidakhazikitsidwa kutengera kuyesedwa kwa dokotala, chifukwa chake omwe sanatenge nawo sanagawidwe mwachisawawa. Zotsatirazi zimasindikizidwa mu BMJ Open Diabetes Research and Care v.

Gulu lomwe latchulidwa pano lasayansi linalimbikitsa kwambiri kuti odwala omwe ali ndi chiopsezo chambiri omwe amadzipatsa mankhwala opewetsa matenda a mtima nthawi zonse amayang'anitsitsa kuchuluka kwa glucose wawo ndikukhala ndi moyo wathanzi.

Mothandizidwa ndi izi, mchaka cha 2012, US Food and Drug Administration idapereka chenjezo lokhudza kuwopsa kwa matenda ashuga odwala omwe amamwa mankhwala ochepetsa mphamvu ya cholesterol komanso kuwongolera glycemic kovuta kwa iwo omwe ali kale ndi matenda a shuga vi.

Chifukwa chakuti ma statins adafotokozedwa kwambiri ku USA ndipo amachepetsa chiwopsezo cha zovuta zamtima zambiri, kukambirana pazomwe zimayambitsa matenda a shuga sikunathebe.

Komabe, posachedwapa, maphunziro omwe akuthandizira chidwi ichi adakula ngati chiwopsezo:

• "Kugwiritsa ntchito ma statins komanso mwayi wokhala ndi matenda ashuga," Barty Chogtu ndi Rahul Bairy, World Journal of Diabetes, 2015 vii,
• "Statins ndi chiwopsezo chotenga matenda ashuga," a Goodarz Danaei, A. Luis Garcia Rodriguez, Cantero Oscar Fernandez, Miguel Hernan A., Matenda a shuga a American Diabetes Association 2013 viii,
• "Kugwiritsa Ntchito Statin Komanso Kuopsa kwa matenda A shuga," a Jill R Crandell, Kiren Maser, Swapnil Rajpasak, RB Goldberg, Carol Watson, Sandra Foo, Robert Ratner, Elizabeth Barrett-Connor, Temproza ​​Marinella, BMJ Open Diabetes Research and Care, 2017 ix,
• "Rosuvastatin yoletsa zochitika zam'mimba mwa abambo ndi amayi omwe ali ndi mapuloteni othandizira a C," Paul M. Ridker, Eleanor Danielson, Francisco HA Fonseca, Jacques Genest, Antonio M. Gotto, John JP Castelein, Wolfgang Cohenig, Peter Libby, Alberto J Lorenzatti, Jean G. MacPheiden, Borg G. Nordeard, a James Shepherd, The New England Journal of Medicine, 2008 x,
• "Kugwiritsa ntchito ma statins kumawonjezera chiopsezo cha matenda amtundu wa 2," a Jack Woodfield, Diabetes.co.uk, 2017 xi
• "Matenda a shuga a Statin komanso zotsatira zake zovuta", Umme Ayman, Ahmad Najmi ndi Rahat Ali Khan, Journal of Pharmacology and Pharmacotherapeutics, 2014 xii.

Nkhani yomaliza ndiyosangalatsa. Amanenanso zambiri zomwe zimapangitsa kuti matenda ashuga ochitika mothandizidwa ndi ma 7ins akhale 7% mpaka 32%, kutengera mtundu wa statin, mlingo wake komanso msinkhu wodwala. Asayansi apeza kuti ma statins nthawi zambiri amayambitsa shuga ndikuwonjezera mayendedwe ake mwa okalamba. Nkhaniyi yatchulanso njira zina zomwe zingapangitse matenda a shuga a 2:

tanthauzo lake lomwe limafupikitsa mwachidule kuti kuwonjezera pakuchepetsa mafuta a cholesterol ndi chiwindi, ma statin amachepetsa kupanga insulin komanso insulin chiwopsezo cha maselo, omwe, amachititsa kutsika kwa kamvekedwe ka minofu ndikutha kuchita masewera olimbitsa thupi.

Zolemba zina zingapo zasayansi zimatsimikizira kuti kugwiritsa ntchito ma statins kuli ndi kufooka kwa minofu ndi kupweteka mkati mwawo chifukwa cha kuperewera kwa cholesterol:

• "Kulumikizana Pakati pa Ma Statins ndi Zolimbitsa Thupi ...", Richard E. Deichmann, Carl Jay Lavi, Timothy Asher, James D. Dinicolantonio, James H. O'Keefe ndi Paul D. Thompson, The Ochsner Journal, 2015 xiii,
• "Mphamvu ya ma statins pamimba la chigoba: masewera olimbitsa thupi, minofu, minofu," a Beth Parker, a Paul Thompson, Othandizira Kuchita Zolimbitsa Thupi ndi Sports Sayansi, 2012 xiv,
• "Kuchepa mphamvu kwa mankhwala a statin?", Ed Fiz, The New York Times, 2017 xv.

Kuphatikiza apo, zolemba zimawonekera kawirikawiri kuti ma statins amawonjezera chiopsezo cha matenda ndi Parkinson, komanso mosiyana ndi zomwe ananena koyambirira kwa xvi xvii xviii xix.

Ndani amafunikira ma statins?

Popeza kuchuluka kwa umboni wa asayansi zakukula kwakubwera kwa ma statins, zofalitsa zina zamankhwala zifunsa madokotala komanso odwala kuti adzifunse ngati phindu logwiritsa ntchito ma statins limaposa zovuta zawo.

Chifukwa chake, mwachitsanzo, ngati wodwala ali ndi mtima wodwala wokhala ndi khunyu yamagazi m'magazi ake, ndiye kuti mwina amafunikabe kumwa ma statins, chifukwa mwina atha kufa nthawi iliyonse. Kuphatikiza apo, ziyenera kukumbukiridwa kuti matenda a shuga sangachitike mwa iye ndi mwayi wa 100%. Ngati cholesterol ya wodwala siyikukwera kwambiri ndipo mtima wa wodwalayo ukakhala wokwanira kapena wosakhutira, ndiye kuti ayenera kudya ndi kuchita masewera olimbitsa thupi. Komabe, ngakhale pankhaniyi, kukana kutenga ma statins kuyenera kuganiziridwanso mogwirizana ndi adokotala ndikuchitika m'magawo komanso mosamala. Makamaka, nkhani "Zotsatira zoyipa za statin: onaninso maubwino ndi zoopsa" za ogwira ntchito ku Mayo Clinic xx zimafuna kuti atero.

Zosindikiza zina, monga, mwachitsanzo, Aspirin vs. Statins, zimawona njira yochotsera ma statin ndi aspirin a odwala omwe si oopsa. Mosiyana ndi ma statins, ma aspirin samachepetsa cholesterol yamagazi, koma amangowononga magazi, kuletsa tinthu tambiri tomwe timagwira m'magazi. Ngakhale akatswiri ena amagwirizana ndi lingaliro ili, ena amakhulupirira kuti aspirin siyingalowe m'malo mwa xxi statins.