Kodi phasostabil kapena Cardiomagnyl ndi chiyani?

Makina a zochita za acetylsalicylic acid (ASA) amachokera pazolepheretsa za cycloo oxygenase (COX-1), chifukwa chomwe kuphatikiza kwa thromboxane A2 kwatsekedwa ndipo kuphatikiza kwa mapulateleti kumakanikizidwa. Amakhulupirira kuti ASA ili ndi njira zina zoponderezera kuphatikizira kwa kupatsidwa zinthu za m'magazi, zomwe zimakulitsa kuchuluka kwake m'matenda osiyanasiyana a mtima. ASA imakhalanso ndi anti-yotupa, analgesic, antipyretic. Mphamvu yotsutsa-kutupa imalumikizidwa ndi kuchepa kwa magazi chifukwa cha kuletsa kwa syntaglandin E2. Magnesium hydroxide, yomwe ndi gawo la mankhwala Fazostabil, imakhala ndi ma antacid zotsatira ndipo imateteza mucous membrane wa m'mimba kuchokera ku zotsatira za ASA.

Zizindikiro zogwiritsidwa ntchito

- Kuteteza kwapakati pa matenda amkati mtima monga thrombosis ndi mtima kulephera pamaso pazinthu zowopsa (mwachitsanzo matenda a shuga, matenda oopsa, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba). - Kupewa mobwerezabwereza myocardial infarction ndi chotupa cha magazi. - Kupewera kwa thromboembolism pambuyo pakuchita opaleshoni yamatumbo (coronary artery bypass grafting, percutaneous translateuminal coronary angioplasty). - Osakhazikika angina

Contraindication

- Hypersensitivity to ASA, excipients and other-non-steroidal anti-yotupa mankhwala (NSAIDs), - Cerebral hemorrhage, - Bleeding tend (kuperewera kwa vitamini K, thrombocytopenia, hemorrhagic diathesis), - Class III-IV aakulu mtima kulephera malinga ndi gulu NYHA, - mphumu ya bronchial yoyambitsidwa ndi ma salicylates ndi NSAIDs, - Kuphatikiza kwathunthu kapena kosakwanira kwa mphumu ya bronchial, polyposis ya mphuno ndi paranasal sinuses, ndi tsankho ndi ASA kapena ma NSAID ena, kuphatikiza ma cycloo oxygenase-2 zoletsa (COX-2) (kuphatikiza mbiri), - zotupa zam'mimba zam'mimba zam'mimba (mu gawo lachiwopsezo), - Kutaya magazi m'mimba, - Kulephera kwa aimpso ( creatinine clearance (CC) osakwana 30 ml / min.), - Kulephera kwa chiwindi (kulera kwa ana-Pugh B ndi C), - Mimba (I ndi III trimesters), nthawi yoyamwitsa, - Glucose-6-phosphate dehydrogenase, - Munthawi yomweyo makonzedwe a methotrexate (oposa 15 mg pa sabata), - Ana ochepera zaka 18.

Mlingo ndi makonzedwe

Mkati mwake, mapiritsi okhala ndi mafilimu a Fazostabil amametsedwa lonse, kutsukidwa ndi madzi. Phazostabil adapangidwira chithandizo chambiri. Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala. - Kupewa koyamba kwamatenda a mtima monga matenda a thrombosis komanso matenda a mtima pachimake pakachitika zinthu zoopsa (mwachitsanzo, matenda a shuga, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba) Piritsi limodzi la mankhwala Phasostabil lili ndi ASA muyezo wa 150 mg koyamba tsiku, ndiye piritsi limodzi lokhala ndi ASA muyezo wa 75 mg 1 nthawi patsiku. - Kupewa pafupipafupi myocardial infarction ndi mtsempha wamagazi thrombosis piritsi 1 la mankhwala a Phasostabil okhala ndi ASA muyezo wa 75-150 mg kamodzi patsiku. - Kupewera kwa thromboembolism pambuyo pakuchita opaleshoni ya mtima (kupindika kwa mitsempha, kulumikizana kolimba) piritsi 1 la mankhwala a Phasostabil okhala ndi ASA muyezo wa 75 - 150 mg kamodzi patsiku. - osakhazikika angina pectoris piritsi 1 la mankhwala a Phasostabil okhala ndi ASA muyezo wa 75-150 mg kamodzi patsiku. Mukadumpha mlingo wotsatira wa mankhwalawa, Phazostabil, ndikofunikira kumwa msanga wa mankhwala mukangokumbukira izi. Popewa kumangodandaula kawiri pa mankhwalawa, simuyenera kumwa piritsi yomwe yasowa ngati nthawi yakumwa mlingo wotsatira. Makhalidwe ochita kuchitikira pakayambitsidwe koyamba kapena kutulutsa mankhwalawa sanawonedwe.

Kutulutsa Fomu

Mapiritsi okhala ndi mafilimu 75 mg + 15.2 mg ndi 150 mg + 30.39 mg. Pa mapiritsi 10, 20, 25 kapena 30 mu mzere wozungulira wa filimu ya polyvinyl chloride ndi cholembera cha aluminiyamu chosindikizidwa. Mbale umodzi kapena 1, 2, 3, 4, 5, 6, 7, 8, 9 kapena 10 mapepala otchinga, pamodzi ndi malangizo ogwiritsira ntchito, aikidwa pabokosi lamakatoni (paketi).

Kufotokozera ndi kufanizira mankhwala

Phasostabil - wothandizira antiplatelet, amapangidwa ku Russia ndi kampani ya Ozone. Mapiritsiwa amapezeka mu zokutira za filimu, zomwe zimachepetsa chiopsezo cha kuwonongeka m'matumbo. Mapiritsiwo ndi oval, oyera ndi marbling, biconvex, okhala ndi mzere wogawanitsa. Mtengo wa mapiritsi 50 ndi ma ruble 218.

Mlingo wa mankhwalawa ndi 150 + 30.39 mg, komanso 75 + 15.2 mg.

Monga gawo la mankhwalawa - acetylsalicylic acid (ASA) mu kuchuluka kwa 150 kapena 75 mg, imawerengedwa kuti ndiyo gawo logwira ntchito. Kuti muwonjezere zochizira, magnesium hydroxide idayambitsidwa ndikuchokera - 30.39 kapena 15.2 mg.

Pogula mankhwala kuti muchepetse magazi, odwala ali ndi chidwi ndi zomwe zili bwino - Phasostabil kapena Cardiomagnyl? Malinga ndi zomwe zikuwonetsa komanso kapangidwe kake, Cardiomagnyl samasiyana ndi Phasostabil. Mulinso kuchuluka komweko kwa magnesium hydroxide ndi acetylsalicylic acid, omwe amapangidwa mwanjira zofananira. Mtengo wa mankhwalawo umachokera ku ma ruble 170 mpaka 300 pa mapiritsi 100, chifukwa chake, palibe kusiyana kulikonse pamtengo. Mankhwalawa amapangidwa ndi Takeda.

Zowonjezera zamapiritsi amitundu yonseyi:

• cellulose
• magnesium wakuba,
• macrogol
• hypromellose.

Pali kusiyana pang'ono pakuphatikizika kwazinthu zina zothandizira. Chifukwa chake, ku Cardiomagnyl pali povidone, titanium dioxide, sodium ya croscarmellose. Ku Phasostabilum, wowuma chimanga ndi mbatata, talc alipo. Chithandizo china chake chitha kukhala chokhacho kwa iwo omwe samayamwa ndi zinthu izi, apo ayi zitsamba ndizosinthika kwathunthu.

Zochita zamankhwala

Kuphatikizikako kumaphatikizapo ASA, komwe kumatanthauza mankhwala omwe si a antiidal. Katunduyu amagwira ntchito molingana ndi makina otsatirawa - amalepheretsa kutulutsidwa kwa enzyme ya COX-1, yomwe imabweretsa kutsekereza kupanga kwa thromboxane A2. Zotsatira zake, izi zimabweretsa kuchepa kwa njira zamagulu a gluing. ASA imachita ndi njira zina zomwe sizimamveka bwino, koma zimabweretsa zotsatira zofananira. Mwa zina, thunthu limakhala ndi zinthu zotsatirazi:

Kuphatikiza pa ASA, magnesium ilipo mu mawonekedwe a hydroxide. Amapangidwa kuti ateteze mucosa wam'mimba ku zowonongeka za acetylsalicylic acid. Magnesium hydroxide ndi ma maacacid, imakuta nembanemba ndipo imalepheretsa yotupa. Mankhwalawa amakhala ndi mayamwidwe athunthu komanso kupezeka kwakukulu, koma ngati mumamwa ndikudya, mphamvu yake imachepa. Mwa akazi, kukonza ndi kuwonongera kwa ASA kumayamba pang'onopang'ono, monga matenda a chiwindi ndi impso.

Zizindikiro za Phasostabil ndi Cardiomagnyl

Mankhwala ayenera kumwedwa ndi matenda osiyanasiyana a mtima. Nthawi zambiri, kuikidwa kwa Cardiomagnyl ndi analogi yake kumalumikizidwa ndi kupewa kwa thrombosis ndi thromboembolism pamaso pazochitika zomwe zingayambitse wodwala:

• ukalamba
• kusuta kwa nthawi yayitali
• matenda ashuga
• kunenepa

Pofuna kupewa mapangidwe amwazi, komanso kupewa mtima kulephera, ndalama zimayikidwa mu zovuta zochizira matenda a matenda a mtima komanso matenda oopsa. Ndi vuto la mtima, Cardiomagnyl nthawi zambiri amalimbikitsidwa kwa nthawi yayitali pakagwiridwe kake kolepheretsa kanthawi kobwereza. Mankhwala amathandizidwanso chifukwa cha matenda amitsempha yamagazi omwe amakhala ndi matenda abwinobwino kapena osakhazikika.

Pambuyo pakuchita opaleshoni yamatumbo amtima (angioplasty, opaleshoni yam'mimba), mankhwalawa sangalole thromboembolism.

Contraindication imaphatikizapo tsankho, ziwengo kwa acetylsalicylic acid, ndi zinthu zina. Kuletsedwa kotheratu kuti muthane ndi mankhwala othandizira kukha magazi, chiwindi chambiri cha vitamini K, ndi thrombocytopenia ndi hemorrhagic diathesis. Kulandila kungayambitse magazi osasamala. Kuletsa kwina:

• 1.3 zokongoletsa zamkati,
• wazaka 18
• kukokoloka, zilonda zam'mimba zopweteka,
• kulephera kwambiri kwaimpso

Moyang'aniridwa ndi dokotala, iwo amamwa mankhwala osokoneza bongo omwe ali ndi mbiri ya gastritis ndi zilonda zam'mimba, matenda a mphumu, bronchial, mucyposis, mu 2 trimester ya amayi apakati.

Malangizo ogwiritsira ntchito

Mankhwala amatengedwa chimodzimodzi, palibe kusiyana pakati pa dongosolo la mankhwala. Zonsezi zimapangidwira kwa nthawi yayitali, koma nthawi yeniyeni ya chithandizo imatsimikiziridwa ndi dokotala malinga ndi momwe wodwalayo alili. Imwani mapiritsi ndi madzi. Nthawi zambiri, Panangin, Asparkam, ndi mankhwala ena amtima amaperekedwa limodzi nawo.

Ngati ndi kotheka, piritsi limatha kugawidwa pachiwopsezo.

Phwando limachitika m'mawa, ola limodzi mutatha kudya. Nthawi zambiri amalimbikitsidwa kuti mumwe Phasostabil kapena Cardiomagnyl kamodzi / tsiku. Nawa malangizo:

kupewa thrombosis, mtima kulephera - 150 g tsiku loyamba, ndiye 75 mg kutalika (mlingo kwa anthu omwe ali pachiwopsezo),

Wodwala akaphonya phwando, mutha kumwa mapiritsi nthawi iliyonse, ngakhale madzulo. Ngati nthawi yayandikira kwa mlingo wotsatira, mlingowo umadumpha, ndipo kuwirikiza kawiri kumaloledwa. Mankhwala osokoneza bongo ndi oletsedwa kwambiri, makamaka odwala okalamba. Poizoni wamphamvu amakula mukamadya mankhwala opitilira 100 mg / kg pa thupi. Chithandizo chili kuchipatala kokha!

Kodi ndi bwino atacecardol kapena Cardiomagnyl?

Acekardol ndi Cardiomagnyl ndi analogi zomwe zimakhudzanso thupi. Kusiyana kwa mankhwalawa sikofunikira, ndipo malangizo omwe angagwiritsidwe ntchito ali ofanana. Mawonekedwe a mankhwala aliwonse ndi kusiyana kwakukulu pakati pawo:

1. Dziko lomwe adachokera. Acekardol ndi mankhwala ku Russia, ndipo Cardiomagnyl amapangidwa ku Germany.
2. Mtengo wa mankhwala. Analogue yopangidwa ku Russia ndiyotsika mtengo kangapo kuposa yakunja.
3. Fomu yamapiritsi. Mankhwala aku Germany amamasulidwa mu mawonekedwe a mitima, komanso mawonekedwe a ellipsoids okhala ndi notch pakati. Wopanga waku Russia amatulutsa mapiritsi ozungulira.
4. Mlingo wa yogwira mankhwala. Piritsi imodzi yamtima imakhala ndi 75 mg ya mankhwala othandizira, piritsi la oval lili ndi 150 mg. Analogue yaku Russia ili ndi 50, 100 ndi 300 mg ya aspirin.
5. The zikuchokera mankhwala. Ogwiritsa ntchito ambiri amakhulupirira kuti Cardiomagnyl ndiyabwino kuposa Acecardol, chifukwa imakhala ndi magnesium hydroxide, yomwe imateteza mucosa wam'mimba pazotsatira zoyipa.

Tsekardol - imodzi mwazifanizo, yokhala ndi anti-kutupa ndi kupatulira magazi. Komabe, ndibwino kufunsa katswiri wamtima kuti asankhe njira yoyenera.

Analogs ndi mavuto

Analogue yotsika mtengo ndi mankhwala Trombital (mtengo wa mapiritsi 100 - ma ruble 230). Njira zina zitha kusankhidwa pamndandanda, onse ali ndi antiaggregant action. Ambiri mulibe mankhwala oteteza, omwe amayenera kuganiziridwa pa chithandizo:

Zotsatira zoyipa, zotsatira zoyipa zimapezeka nthawi zina, nthawi zina zimafika pamlingo woopsa, mpaka anaphylaxis. Nthawi zambiri, urticaria, zidzolo, khungu limayamba. Kuchokera m'mimba thirakiti, nseru, kutentha pa chifuwa, kupweteka pamimba ndi m'mimba zimatha. Milandu yayikulu, zilonda zam'mimba, kufalikira kwa gastritis kumachitika. Nthawi zina, magazi ochokera m'matumbo, kukokoloka kwa esophagus, esophagitis amalembedwa. Ndi kuvomerezeka kwanthawi yayitali, masinthidwe a esophageal adadziwika mu odwala angapo. Nthawi zambiri, matumbo osakwiya amayamba.

Dzinalo Lopanda Padziko Lonse

INN yamankhwala awa ndi Acetylsalicylic acid + Magnesium hydroxide.

Mu gulu la padziko lonse la ATX, mankhwalawo ali ndi code B01AC30.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi zokutira zamafuta.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi zokutira zamafuta. Mlingo wa mapiritsi ndi 75 mg ndi 150 mg. Zida zazikulu zomwe zimagwiritsidwa ntchito ndi mankhwalawa ndi acetylsalicylic acid muyezo wa 75 kapena 150 mg ndi magnesium hydroxide wokwanira 15 kapena 30 mg. Mwa zina, kapangidwe ka mankhwalawa amaphatikizapo zinthu zothandiza monga wowuma, talc, hypromellose, magnesium stearate, macrogol ndi cellulose.

Mapiritsi a 75 mg ali ngati mawonekedwe a mtima wokhazikika. Mankhwala okhala ndi Mlingo wa 150 mg ali ndi mawonekedwe owulungika. Mapiritsi amadzaza mabokosi apulasitiki 10. Timatumba tadzaza timabokosi takhadi, momwe malangizowo amaphatikizidwira.

Pharmacokinetics

Zigawo zogwira ntchito za Phasostabil zimatsala pang'ono kulowa kwathunthu m'makoma am'mimba. Ndi gawo la michere ya chiwindi, chinthu chogwira ntchito chimasinthidwa kukhala salicylic acid. Kuchuluka kwa plasma ndende yogwira ntchito ndi ma metabolites awo amafikira pafupifupi maola 1.5. Zomwe zimagwiritsa ntchito mankhwalawa zimamangiriza pafupifupi mapuloteni a plasma. Zinthu zosweka za mankhwalawa zimachotsedwa m'thupi pakatha masiku awiri.

Zigawo zogwira ntchito za Phasostabil zimatsala pang'ono kulowa kwathunthu m'makoma am'mimba.

Kodi chimathandiza ndi chiyani?

Kugwiritsa ntchito phasostabil kukuwonetsedwa pamapangidwe otetezera matenda a mtima ndi mitsempha ya magazi, kuphatikiza kulephera kwa mtima. Nthawi zambiri, mankhwalawa amalembedwa pokonzanso Mlingo kwa anthu omwe ali pachiwopsezo chotenga matenda a mtima, kuphatikiza odwala omwe ali ndi matenda a shuga, kunenepa kwambiri, matenda oopsa. Chida chitha kutumikiridwa kuti chichepetse magazi ngati mbali yopewa kupewanso kwa myocardial infarction kapena pachimake thrombosis.

Mwa zina, mankhwalawa amatha kugwiritsidwa ntchito pa thromboembolism yam'mitsempha yam'mapapo. Mankhwalawa nthawi zambiri amaperekedwa pochiza matenda osakhazikika a angina pectoris. Kuphatikiza apo, mankhwalawa angagwiritsidwe ntchito ngati gawo la kupewa kwa thrombosis pambuyo pakuchita opaleshoni ya mtima.

Ndi chisamaliro

Kugwiritsa ntchito phasostabil pochiza odwala omwe ali ndi hyperuricemia kapena gout kumafuna kusamala kwapadera. Kuphatikiza apo, kuyang'aniridwa kwapadera ndi madokotala kumafunikira mukamagwiritsa ntchito mankhwalawa pochiza odwala omwe ali ndi mbiri yakutuluka magazi m'mimba.

Kugwiritsa ntchito phasostabil kukuwonetsedwa pamapangidwe otetezera matenda a mtima ndi mitsempha ya magazi, kuphatikiza kulephera kwa mtima.
Nthawi zambiri mankhwalawa amaperekedwa kwa anthu omwe ali ndi matenda ashuga.
Nthawi zambiri, mankhwalawa amaperekedwa kwa anthu onenepa kwambiri.
Mankhwalawa angagwiritsidwe ntchito ngati gawo la kupewa kwa thrombosis pambuyo pakuchita opaleshoni ya mtima.

Matumbo

Mbali yamatumbo, zotsatira zoyipa zimawonedwa nthawi zambiri. Odwala nthawi zambiri amakhala ndi kutentha kwamphepo, nseru, komanso kusanza. Kupweteka kwam'mimba. Chiwopsezo cha kukhala ndi stomatitis, colitis, kukokoloka kwa mucosa kwa m'mimba thirakiti, ndi zina zambiri.

Khansa ya m'magazi ndi imodzi mwazinthu zoyipa zomwe zimachitika m'thupi pakumwa mankhwalawo.

Pa khungu

Pamaso pa tsankho la payekha, zotupa pakhungu ndi kuyabwa kungachitike.

Pamaso pa tsankho la payekha, zotupa pakhungu ndi kuyabwa kungachitike.

Nthawi zambiri, odwala omwe amathandizidwa ndi Phasostabil amakhala ndi urticaria. Kugwedezeka kwa anaphylactic ndi edema ya Quincke kumatha.

Kugwiritsa ntchito kwa vuto la chiwindi

Kwa odwala omwe ali ndi chiwindi chochepetsedwa, mankhwalawa amaperekedwa pokhapokha akuwonetsa mosamala.

Kwa ana, mankhwalawa saikidwa.
Kugwiritsa ntchito phasostabil panthawi yoyembekezera sikulimbikitsidwa.
Kugwiritsa ntchito phasostabil pochiza odwala omwe ali ndi vuto laimpso kumafuna kuwongolera kwapadera.
Kwa odwala omwe amachepetsa chiwindi, mankhwalawa amaperekedwa pokhapokha malinga ndi mawonekedwe okhwima.

Kuyenderana ndi mowa

Pa mankhwala a phasostabil, kumwa mowa kuyenera kusiyidwa.

Pa mankhwala a phasostabil, kumwa mowa kuyenera kusiyidwa.

Mankhwala omwe ali ndi vuto lofananalo, akuphatikizapo:

1. Cardiomagnyl.
2. Bulu wamphongo.
3. Supombital.
4. Clopidogrel.
5. Kukhomedwe

Ndemanga za madotolo za Phasostabilus

Vladislav, wazaka 42, ku Moscow

Odwala okalamba omwe ali pachiwopsezo chodwala matenda a mtima nthawi zambiri amapatsidwa Phasostabil. Nthawi zambiri, ndimayamba ndimalimbikitsa kuchuluka kwa 20 mg kenako ndikuwonjezera pang'onopang'ono. Izi zimachepetsa chiopsezo cha zovuta. Muyenera kumwa mankhwalawa nthawi yayitali.

Irina, wazaka 38, Chelyabinsk

Machitidwe anga, ndimakonda kulemba Phazostabil kwa odwala omwe ali pachiwopsezo chachikulu cha thrombosis. Chidacho chimachepetsa chiopsezo cha thromboembolism ndi zovuta zina za thrombosis. Mankhwala samayambitsa odwala. Pankhaniyi, kusintha kwa mankhwala ndi analogue ndikofunikira.

Ndemanga za Odwala

Igor, wazaka 45, Rostov-on-Don

Pafupifupi zaka 3 zapitazo, ndidayamba kupita kuchipatala ndi angina pectoris. Pambuyo kukhazikika, adokotala adayambitsa Phasostabil. Ndimamwa mankhwalawa tsiku lililonse. Zinthu sizikuipiraipira. Kuphatikiza apo, mtengo wotsika wa mankhwalawo amasangalala.

Kristina, wazaka 58, Vladivostok

Ndakhala ndikuvutika ndi matenda oopsa kwa zaka zambiri. Ndimamwa mankhwala osokoneza bongo kuti ndikhale wolimba. Pafupifupi chaka chapitacho, adotolo adatumiza Phasostabil, koma mankhwalawo siandiyenera. Pambuyo pa mapiritsi oyamba, kunyansidwa kwambiri, kusanza, ndi kupweteka kwam'mimba kunawonekera. Ndinayenera kukana kugwiritsa ntchito chida ichi.

Zisonyezero zogwiritsidwa ntchito: Chifukwa chanji

Phasostabil akuwonetsedwa kuti agwiritse ntchito pazinthu zotere:

• Ngati njira yolepheretsa kufalikira kwa mitsempha pambuyo pakuchita opaleshoni yokhudzana ndi mtima.
• kuteteza kuwoneka kwa magazi m'magazi a mtima komanso kupangitsanso kupangika kwa myocardial,
• pa zochizira motsutsana ndi angina wosakhazikika,
• mwa njira zoyambira zodzitetezera kuti mupeze kukula kwa mtima komanso kusokonekera kwa magazi m'mitsempha yamagazi motsutsana ndi zomwe zimayambitsa matenda monga matenda a shuga, matenda oopsa, kusuta, kukodzetsa magazi lipids, kunenepa kwambiri, ukalamba.

Malangizo apadera

Acetylsalicylic acid, yomwe ndi yogwira ntchito ya Phasostabil, imatha kuyambitsa matenda amphumu, bronchospasm ndi zina zomwe hypersensitivity zimachitika.

Gulu langozi limaphatikizapo anthu omwe ali ndi mbiri ya mphumu, chifuwa cha mankhwala ena, kupuma matenda, polyposis m'mphuno ndi zowonjezera zam'mimba, hay fever (hay fever).

Ngati opaleshoni ikuyenera kuchitidwa, ndikofunikira kudziwitsa dokotala kuti wodwala amamwa mankhwala omwe ali ndi acetylsalicylic.

Ngati pali chiyembekezo cha mapangidwe a mtima ndi mtima, ndikofunikira kupewa nthawi yomweyo kugwiritsa ntchito aspirin ndi ibuprofen. Ngati ibuprofen imagwiritsidwa ntchito kuti muchepetse ululu, ndikofunikira kudziwitsa dokotala.

Masabata oyamba omwe amathandizidwa ndi Phasostabilum ndi methotrexate (pazipita 15 mg pa sabata) ayenera kuperekedwa sabata iliyonse kuti ayesedwe maabara. Kuwunikira mosamala za vutoli ndikofunikira ngati pali kuphwanya kwa ntchito yaimpso (ngakhale ocheperako) kwa anthu azaka zaukalamba.

Ngati ma lithiamu omwe ali ndi ma lithiamu kapena digoxin adayikidwa limodzi ndi Phazostabil, kuwunika zomwe zili mu plasma ya magazi ndikofunikira. Kuyendera koteroko kumalimbikitsidwa kuti kuchitike koyambirira kwa chithandizo kapena kumapeto. Nthawi zina, mlingo ungasinthidwe.

Zofunika! Ngati mankhwala a Phazostabil adalembedwa kwa nthawi yayitali, ndikofunikira kuyesa mankhwala opangira ma ndowe kuti pakhale magazi obisika, kuyezetsa magazi ku chipatala, ndikuwunika momwe chiwindi chimagwira.

Acetylsalicylic acid pamlingo waukulu amatha kudziwa vuto la hypoglycemic, lomwe liyenera kukumbukiridwa ngati munthu wapezeka ndi matenda a shuga.

Kukonzekera komwe kumakhala ndi mulingo wochepa wa acetylsalicylic acid kumathandizira kuchepetsa urea, komanso nthawi zina kumabweretsa mapangidwe a gout mwa anthu ochepetsedwa urea omwe amakonda kuchita izi.

Ndi vuto lalikulu la glucose-6-phosphate dehydrogenase, pulotini ingayambitse mapangidwe a hemolytic anemia ndi hemolysis. Gulu lowopsa pankhaniyi limaphatikizapo odwala omwe amamwa mankhwala oledzera omwe amapezeka kwambiri, komanso anthu omwe ali ndi matenda oopsa komanso malungo.

Pa mimba ndi mkaka wa m`mawere

Ndi koletsedwa kumwa mankhwalawa panthawi yoyamwa

Tengani Phasostabil adasokonekera mu akazi omwe ali ndiudindo mkati mwa 1 ndi 3 trimester. Nthawi ya 2nd trimester, mankhwalawa amatha kutumikiridwa mu mlingo wa tsiku ndi tsiku wambiri wa 150 mg ngati njira yochepa yothandizira.

Musanapitilize kugwiritsa ntchito, ndikofunikira kuwunika kuchuluka kwa kuopsa kwa mwana mtsogolo ndi phindu la mayi.

Ndizosatheka kugwiritsa ntchito Phazostabil mukamayamwa.

Phasostabil kapena Thrombo Ass: zomwe zili bwino

Mankhwalawa ali ndi fanizo lathunthu pazogwira ntchito. Komabe, mankhwala osokoneza bongo a thrombotic (phasostabil) amagwira ntchito ngati wogulitsa antiplatelet wakunja. Kuphatikiza apo, Phazostabil ndi wotsika mtengo kwambiri, womwe ndi mwayi wina pa chida ichi.

Phasostabil ndi Cardiomagnyl: pali kusiyana kotani

Cardiomagnyl imapangidwa m'mitundu iwiri, kusiyana pakati pa komwe kumakhala mlingo. Chimodzi mwazosiyana ndi mndandanda wa mwachindunji wa Phazostabil (uli ndi acetylsalicylic acid ndi magnesium hydroxide pang'ono. Zotsatira zake, ngati Cardiomagnyl yakhazikitsidwa pamodzi ndi zomwe zili ndi zosakaniza zolimbitsa thupi ndi 150 ndi 30.39 mg (pa piritsi limodzi), ndizotheka kuti matendawa akhale olimba. Zotsatira zabwino pamilandu iyi zitha kupezeka posachedwa. Ngakhale pali chitukuko chambiri cha zoyipa zamagetsi. Zotsatira zake, pali mwayi wowonjezera chiwopsezo cha zovuta, makamaka makamaka pamimba.

Mndandanda wazofananira

Zokhudza mankhwala omwe ali ndi vuto lofananalo, pakati pawo titha kudziwa:

Mtengo ndi tanthauzo la tchuthi ku malo ogulitsa mankhwala

Phasostabil ikhoza kugulidwa ku malo ogulitsa mankhwala popanda mankhwala kuchokera kwa dokotala. Phukusi la mapiritsi 10 limakhala pakati pa ma ruble a 130-218.

Ndemanga za mankhwalawa zabwino. Phasostabil nthawi zambiri amalembedwa pamavuto a mtima ndi mitsempha yamagazi, imawerengedwa ngati mankhwala osavulaza komanso othandiza. Kupezeka kwa zoyipa zamomwe zimachitika panthawi ya mankhwala ndi mankhwalawa zimadziwika kawirikawiri.

Mankhwala

Kuchita kwa Phasostabil kumachitika chifukwa cha zomwe amagwira - acetylsalicylic acid (ASA). Imalepheretsa cycloo oxygenase mosaletseka (COX-1), kuchititsa kuti zilepheretse kapangidwe ka thromboxane A₂ ndi kuponderezana kwa kuphatikiza kuphatikizira kwa maselo. Amakhulupirira kuti ASA ilinso ndi njira zina zoponderezera kuphatikizira kwa kupatsidwa zinthu za m'magazi, zomwe zimakulitsa kukula kwake kwa odwala omwe ali ndi matenda osiyanasiyana a mtima. Mankhwalawa amakhalanso ndi antipyretic, anti-kutupa komanso analgesic.

Magnesium hydroxide - yachiwiri yogwira ntchito ya Phasostabil - imakhala ndi maacacid, imateteza mucous membrane wa m'mimba thirakiti (GIT) kuchokera ku kukhumudwitsa kwa ASA.

Ndi chiwindi ntchito

Phasostabil amatsutsana mu milandu ya kuchepa kwa hepatic ya gulu B ndi C malinga ndi gulu la Mwana-Pugh (wolimbitsa komanso woopsa).

Mochenjera, mankhwalawa amayenera kugwiritsidwa ntchito pochiza odwala omwe ali ndi kalasi A hepatic insuffuffence malinga ndi Gulu-Pugh gulu (kufatsa kwambiri), ntchito ya chiwindi iyenera kuyang'aniridwa pafupipafupi.

Kuyanjana kwa mankhwala osokoneza bongo

ASA imawonjezera zotsatira ndikuwonjezera kuwopsa kwa mankhwala otsatirawa:

• valproic acid - chifukwa chosamutsidwa kulumikizana ndi mapuloteni a plasma,
• methotrexate - chifukwa cha kuchepa kwa chilolezo cha impso ndi kuchoka kwake pakuyankhulana ndi mapuloteni a plasma.

ASA imawonjezera mphamvu ndi chiwopsezo cha mavuto obwera chifukwa cha mankhwalawa:

• sulfonamides, kuphatikiza co-trimoxazole - chifukwa cha kuchuluka kwawo kwa magazi ndi kutuluka kwawo polumikizana ndi mapuloteni a plasma,
• ma NSAID ena, analcics ya narcotic - chifukwa cha mayanjano ochitika,
• carbonic anhydrase inhibitors, kuphatikiza acetazolamide - ma salicylates amatha kuonjezera kawopsedwe wawo ku chapakati mantha dongosolo komanso mwayi wokhala ndi acidosis yayikulu.
• lifiyamu ndi digoxin - chifukwa cha kuchepa kwa kuphipha kwawo kwa impso ndi kuchepa kwa kuchuluka kwa plasma,
• kusankha serotonin reuptake inhibitors, kuphatikizapo sertraline ndi paroxetine - chifukwa cha synergism ndi ASA, chiopsezo chotaya magazi kuchokera kumtunda wam'mimba kwambiri,
• antiplatelet othandizira, kuphatikiza clopidogrel ndi dipyridamole, anticoagulants osadziwika, kuphatikiza ticlopidine ndi warfarin, othandizira a thrombolytic, heparin chifukwa chakuchotsedwa kwa zovuta zazikulu chifukwa chogwirizana ndi mapuloteni amadzi a plasma,
• Hypoglycemic mkamwa othandizira omwe amapezeka ndi sulfonylureas ndi insulin - popeza ASA mu Mlingo watsiku ndi tsiku woposa 2000 mg amawonetsa zochitika za hypoglycemic, kuphatikiza apo, imasokoneza zotumphukira za sulfonylurea polumikizana ndi mapuloteni a plasma,
• Mowa ndi zakumwa zoledzeretsa - chifukwa cha kuchuluka kowonjezera, kuwonongeka kwa mucosa am'mimba kumawonjezeka ndipo nthawi yotuluka magazi imakulitsidwa.

Mankhwala otsatirawa amachepetsa katundu wa antiplatelet wa ASA:

• colestyramine ndi ma antacid okhala ndi magnesium ndi / kapena aluminium hydroxide - chifukwa cha kuchepa kwa mayankho a ASA m'mimba,
• dongosolo glucocorticosteroids, kupatula hydrocortisone, zotchulidwa m'malo mankhwala a matenda a Addison - chifukwa kuchuluka kuchotsedwa kwa salicylates,
• ibuprofen - chifukwa cha kuwonetsedwa kwa malo a wotsutsana ndi kuponderezedwa kwa kuphatikiza kwa ma cell.

Mlingo wocheperako, ASA imafooketsa mphamvu ya uricosuric agents (sulfinpyrazone, probenecid, benzbromarone), chifukwa cha mpikisano kutha kwa uric acid.

Mlingo wambiri, ASA imatha kuchepetsa kuthamanga kwa okodzetsa (chifukwa kuchepa kwa kuchuluka kwa kusefera kwa mafuta pomwe imaletsa kaphatikizidwe ka impso prostaglandins) ndi antihypertensive mankhwala. Makamaka, ASA imatha kuchepetsa zotsatira za ACE zoletsa chifukwa cha mpikisano wothana ndi kapangidwe ka prostacyclin.

Zofanizira za Phazostabil ndi Agrenox, Antagrex, Aspirin Cardio, Brilinta, Ventavis, Detrombe, Ilomedin, Sylt, Cardiomagnyl, Clapitax, Cardogrel, Clopidogrel, Lirta, Monafram, Plavix, Sanovask, Trombeks, Trombomag.

Mtengo wa phasostabil muma pharmacies

Mtengo wa Phasostabil umatengera mlingo, kuchuluka kwa mapiritsi omwe ali phukusili, komanso dera logulitsira komanso unyolo wamankhwala omwe amagulitsa mankhwalawa.Mtengo wokwanira phukusi la mapiritsi 100 okhala ndi mafilimu, 75 mg + 15.2 mg aliyense, ndi ma ruble a 133- 154, ndi ma 150 mg + 30.39 mg aliyense - 198-325 ma ruble.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Kupewera kwa mtima ndi matenda a mtima monga thrombosis ndi mtima kugundika ndi vuto:

Piritsi limodzi la mankhwala a Phazostabil lomwe lili ndi ASA pa mlingo wa 150 mg tsiku loyamba, ndiye piritsi limodzi lokhala ndi ASA pa 75 mg kamodzi patsiku.

Kupewera kwa myocardial infarction ndi chotupa cha magazi

Piritsi 1 la mankhwala Fazostabil wokhala ndi ASA muyezo wa 75-150 mg 1 nthawi patsiku.

Kupewa kwa thromboembolism pambuyo pakuchita opaleshoni ya mtima (kupindika kwa mitsempha yodutsa m'mitsempha, kulumikizana kolimba mtima)

Piritsi 1 la mankhwala Fazostabil wokhala ndi ASA muyezo wa 75-150 mg 1 nthawi patsiku.

Piritsi 1 la mankhwala Fazostabil wokhala ndi ASA muyezo wa 75-150 mg 1 nthawi patsiku.

Zotsatira zoyipa

Pa mbali ya chitetezo cha mthupi: pafupipafupi - urticaria, angioedema (edema ya Quincke), zotupa pakhungu, kuyabwa, rhinitis, kutupa kwa mphuno, osowa - anaphylactic kugwedezeka, matenda a cardio-kupuma.

Kuchokera impso ndi kwamikodzo thirakiti: kawirikawiri - kuwonongeka kwaimpso.

Kuchokera kwamanjenje: Nthawi zambiri - kupweteka mutu, kugona, kusowa - chizungulire, kugona, kawirikawiri - tinnitus, intracerebral hemorrhage.

Pali malipoti amilandu ya hemolysis ndi hemolytic anemia mwa odwala kwambiri shuga-6-phosphate dehydrogenase.

Pa gawo la magazi ndi mitsempha yam'mimba: magazi ambiri - magazi ochulukirapo, kawirikawiri - aplastic anemia, hypoprothrombinemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, agranulocytosis.

Kuchokera pakapumidwe, m'chifuwa ndi ziwalo zam'mimba: nthawi zambiri - bronchospasm.

Kuchokera pamimba: stomatitis, esophagitis, zotupa za chapamimba pamatumbo (kuphatikiza ndi kupindika), colitis, matumbo osakwiya.

Kuchita

Ndi munthawi yomweyo kugwiritsa ntchito ASA kumawonjezera zotsatira ndi kumawonjezera chiopsezo cha kawopsedwe:

- methotrexate (chifukwa cha kuchepa kwa chilolezo cha impso ndi kuchoka kwake pakulankhulana ndi mapuloteni amadzi a m'magazi),

- valproic acid (chifukwa chosamukirana ndi ma protein a plasma),

ASA imathandizira kuchitapo kanthu ndikuwonjezera chiopsezo cha zotsatira zosafunika:

- narcotic analgesics, mankhwala ena osapweteka a antiidal (chifukwa cha mgwirizano wa zochita)

- othandizira a hypoglycemic operekera pakamwa (sulfonylurea zotumphukira) ndi insulin chifukwa cha hypoglycemic katundu wa ASA palokha waukulu (oposa 2 g pa tsiku) ndi kutalikirana kwa zotumphukira za sulfonylurea kuchokera kumayanjano ndi mapuloteni amadzi a plasma

- othandizira a thrombolytic, heparin, anticoagulant (ticlopidine, warfarin), ma antiplatelet othandizira (kuphatikizapo clopidogrel, dipyridamole) - chifukwa cha mgwirizano pakati pazomwe zimachitika chifukwa cha mapuloteni a plasma.