Momwe mungagwiritsire ntchito Ciprofloxacin 250?

Kufotokozera kogwirizana ndi 20.08.2015

Dzina lachi Latin: Ciprofloxacinum
Code ya ATX: S03AA07
Chithandizo: Ciprofloxacin (Ciprofloxacinum)
Wopanga: PJSC Farmak, PJSC Technolog, Kyivmedpreparat OJSC (Ukraine), Ozon LLC, Veropharm OJSC, Synthesis OJSC (Russia), C.O. Kampani ya Rompharm S.R.L. (Romania)

Khutu ndi Diso limagwera ciprofloxacin muli ciprofloxacin hydrochloride pa ndende ya 3 mg / ml (malinga ndi zinthu zopanda pake), Trilon B, benzalkonium chloride, sodium chloride, madzi oyeretsedwa.

Mafuta amaso, chinthu chogwira ntchito chimaphatikizidwanso 3 mg / ml.

Mapiritsi a Ciprofloxacin: 250, 500 kapena 750 mg wa ciprofloxacin, MCC, wowuma wa mbatata, wowuma chimanga, hypromellose, croscarmellose sodium, talc, magnesium stearate, colloidal anhydrous silicon dioxide, macrogol 6000, E171 yowonjezera (titanium dioxide), polysorbate 80.

Kulowetsedwa njira Muli yogwira pophika 2 mg / ml. Omwe amathandizira: sodium chloride, edetate disodium, lactic acid, kuchepetsedwa hydrochloric acidmadzi d / ndi.

Mankhwala

Kapangidwe kake ka mankhwalawa chifukwa chakuletsa kulepheretsa DNA gyrase (mphamvu ya mabakiteriya) yokhala ndi vuto la kuphatikizika kwa DNA, magawidwe ndi kukula kwa tizilombo.

Wikipedia ikuwonetsa kuti, motsutsana ndi kugwiritsidwa ntchito kwa mankhwalawa, kukana kwa ena omwe si gyrase inhibitors sikupangidwa, maantibayotiki. Izi zimapangitsa chiprofloxacin kukhala yothandiza kwambiri polimbana ndi mabakiteriya osagwira ntchito. penicillin, malo oyatsira moto, mchiyama, cephalosporins ndi ena angapo maantibayotiki.

Ogwira ntchito kwambiri motsutsana ndi Gram (-) ndi Gram (+) aerobes: H. fuluwenza, N. gonorrhoeae, Salmonella spp., P. aeruginosa, N. meningitidis, E. coli, Shigella spp.

Kugwiritsa ntchito matenda oyambitsidwa ndi: tizilombo ta staphylococcus (kuphatikiza omwe amapanga penicillinase), zovuta zingapo enterococcus, legionella, campylobacter, chlamydia, mycoplasma, mycobacteria.

Yogwira polimbana ndi microslora ya beta-lactamase.

Anaerobes amakhala ocheperako kapena osamva mankhwala. Chifukwa chake, odwala osakanikirana matenda a anaerobic ndi aerobic mankhwala a ciprofloxacin ayenera kuthandizidwa ndi mankhwala lincosamides kapena Metronidazole.

Kukana mankhwala ndi: Ureaplasma urealyticum, Streptococcus faecium, Treponema pallidum, Nocardia asteroides.

Kukana kwa ma microorganic mankhwala kumapangidwa pang'onopang'ono.

Pharmacokinetics

Mutatha kumwa mapiritsi, mankhwalawa amayamwa mwachangu komanso mokwanira.

Zizindikiro zazikulu za pharmacokinetic:

bioavailability - 70%,
TCmax m'magazi am'magazi - maora 1-2 pambuyo pa kuperekedwa,
T½ - maola 4

Pakati pa 20 ndi 40% ya chinthucho chimamangiriza mapuloteni a plasma. Ciprofloxacin imagawidwa bwino mu zinthu zamadzimadzi ndi ziwalo zathupi, ndipo kuphatikiza kwake m'matipi ndi zamadzimadzi amatha kupitilira plasma.

Imadutsa mwa placenta kulowa mu madzi a cerebrospinal, imakhudzidwa mkaka wa m'mawere, ndipo kutsika kwakukulu kumakhazikika mu bile. Mpaka 40% ya mankhwalawa atengedwa amachotsedwa patatha maola 24 osasinthika ndi impso, gawo lina limatulutsidwa mu ndulu.

Kodi mankhwalawa ali ngati mawonekedwe amaso / makutu amkhutu?

Mu ophthalmology imagwiritsidwa ntchito matenda oyambitsidwa ndi bakiteriya amaso (diso) ndi zowonjezera zake, komanso ulcerative keratitis.

Zisonyezero zogwiritsira ntchito ciprofloxacin mu otology: pachimake bakiteriya otitis externa ndi pachimake bakiteriya otitis media pakati khutu odwala tympanostomy chubu.

Contraindication

Contraindication yogwiritsira ntchito kwadongosolo:

Hypersensitivity
mimba
nyere
kutchulidwa kukanika kwa impso / chiwindi,
zikuwonetsa mbiri ya teninitis yoyambitsidwa ndi kugwiritsa ntchito ma quinolones.

Madonthowa amaso ndi makutu amatsutsana fungal ndi matenda a maso / makutu, kulekerera ciprofloxacin (kapena mitundu ina ya quinolones), panthawi yoyembekezera komanso mkaka wa m'mawere.

Kwa ana, mapiritsi ndi yankho la utsogoleri wa iv akhoza kufotokozedwa kuyambira azaka 12, maso ndi khutu zimatsika kuchokera wazaka 15.

Zotsatira zoyipa

Mankhwala amalekeredwa bwino. Zotsatira zoyipa zomwe zimakhala ndizoyambitsa ndi kuyambitsa ndi kuyamwa:

chizungulire
kutopa
mutu
kunjenjemera
wokongola.

Mu buku la Vidal, akuti nthawi zambiri, odwala adalembedwa:

thukuta
mavuto
zosokoneza zotumphukira,
mafunde,
intracranial matenda oopsa,
kukhumudwa,
kumverera kwa mantha
kuwonongeka kwamawonekedwe
chisangalalo,
kupweteka m'mimba
kudzimbidwa,
kusanza / kusanza
kutsegula m'mimba,
chiwindi,
hepatocyte necrosis,
tachycardia,
ochepa matenda oopsa(kawirikawiri)
Khungu
mawonekedwe a totupa pakhungu.

Zotsatira zoyipa kwambiri: bronchospasm, anaphylactic mantha, Edema wa Quincke, arthralgia, petechiae, zilonda zoyipa za erythema, vasculitis, Matenda a Lyell, leukemia ndi thrombocytopenia, eosinophilia, kuchepa magazi, hemolytic anemia, thrombotic kapena leukocytosis, kuchuluka kwa plasma wozungulira LDH, bilirubin, zamchere phosphatase, chiwindi transaminases, creatinine.

Ntchito mu ophthalmology limodzi ndi:

Nthawi zambiri - kumverera kwachisoni komanso / kapena kupezeka kwa thupi lakunja m'diso, mawonekedwe a chida choyera (nthawi zambiri mwa odwalaulcerative keratitis ndi kugwiritsa ntchito madontho pafupipafupi), mapangidwe a makhiristo / ma flakes, kuphatikizika kwa conjunctival ndi hyperemia, kumva kulira ndi kuwotcha,
panokha - keratitis/keratopathy, eyelid edema, madontho a ziphuphu zakumaso, kuchepa kwa magazi, kuchemerera, kuchepa kuwona kwakukhalitsa, kujowoka, kulowerera.

Zotsatira zoyipa zomwe zimakhudzana ndi kapena kugwiritsa ntchito mankhwalawa nthawi zambiri zimakhala zofatsa, sizowopsa ndipo zimapita osalandira chithandizo.

Odwala ulcerative keratitis maonekedwe oyera ngati ating kuyanika samakhudza kuchiritsa kwa matendawa komanso mawonekedwe a mawonekedwe ndikudziwonekera pawokha. Monga lamulo, limawonekera pakadutsa masiku 1-7 kuchokera pamene ntchito ya mankhwalawa idayamba ndipo imazimiririka nthawi yomweyo kapena mkati mwa masiku 13 itatha ntchito.

Matenda a neophthalmic mukamagwiritsa ntchito madontho: kuwoneka kosangalatsa kosangalatsa pambuyo pakamwa, m'malo osowa - nseru, dermatitis.

Mukagwiritsidwa ntchito mu otology, izi ndizotheka:

Nthawi zambiri - kugwetsa khutu,
Nthawi zina - tinnitus, mutu, dermatitis.

Kugwiritsa ntchito ma ampoules

Ciprofloxacin mu ampoules tikulimbikitsidwa kuti azitha kutumikiridwa kudzera mu mawonekedwe a kulowetsedwa. Mlingo wa munthu wamkulu ndi 200-800 mg / tsiku. Kutalika kwa maphunzirowa kuli pafupifupi sabata limodzi mpaka masiku 10.

At matenda a urogenital, kuwonongeka kolumikizanandimafupa kapena Ziwalo za ENT wodwalayo ali ndi jekeseni ya 200-400 mg kawiri pa tsiku. At matenda kupuma thirakiti, matenda okhudzidwa, septicemia, minofu yofewa komanso zotupa za pakhungu Mlingo umodzi womwe umagwiritsidwa ntchito pafupipafupi ndi 400 mg.

At kukanika kwa impso mlingo woyambira ndi 200 mg, kenako umasinthidwa poganizira Clcr.

Pankhani ya kugwiritsa ntchito ma ampoules muyezo wa 200 mg, nthawi ya kulowetsedwa ndi mphindi 30, ndikutsegulidwa kwa mankhwala mu 400 mg - 1 ora.

Jakisoni wa Ciprofloxacin sichinapangidwe.

Zosankha

Palibe kusiyana kwakukulu pamomwe mungatengere mankhwala kuchokera kwa opanga osiyanasiyana: malangizo ogwiritsira ntchito Ciprofloxacin-AKOS zofanana ndi malangizo a Ciprofloxacin-FPO, Waprofloxacin-Wolonjezedwa, Vero-Ciprofloxacinkapena Ciprofloxacin-teva.

Kwa ana ndi achinyamata osakwana zaka 18, mankhwalawa amalimbikitsidwa kuti azingolemba pokhapokha ngati tizilomboti tikugonjera othandizira ena a chemotherapeutic.

Bongo

Palibe zizindikiro zenizeni zokhala ndi bongo wa ciprofloxacin. Wodwalayo amawonetsedwa zam'mimba, amatenga mankhwala a emetic, kupanga acid acid mkodzo, ndikuwonetsa kuchuluka kwamadzi. Zochita zonse ziyenera kuchitika ndikusungabe kachitidwe ka zida zofunika komanso ziwalo.

Peritoneal dialysis ndi hemodialysis amathandizira kuti 10% ya mankhwalawa atengedwe.

Mankhwala alibe mankhwala enaake.

Kuchita

Gwiritsani ntchito limodzi Theofylline zimathandizira kuwonjezeka kwa ndende ya plasma komanso kuwonjezeka kwa T1 / 2 kwa omaliza.

Ma alacid okhala ndi Al / Mg amathandizira kuchepetsa kuyamwa kwa ciprofloxacin ndipo potero amachepetsa kuyamwa kwake mu mkodzo ndi magazi. Pakati Mlingo wa mankhwalawa ayenera kusungidwa pafupipafupi maola 4.

Ciprofloxacin imathandizira zotsatira zake coumarin anticoagulants.

Kugwirizana kwa ciprofloxacin wogwiritsidwa ntchito mu otology ndi ophthalmology ndi mankhwala ena sikunaphunzire.

Malangizo apadera

Chifukwa cha zovuta zoyambira pakati pa dongosolo lamanjenje pakati pa odwala omwe ali ndi mbiri ya matenda ake, mankhwalawa amatha kugwiritsidwa ntchito pazifukwa zaumoyo.

Ciprofloxacin imayikidwa mosamala mukatsitsa njira kuti munthu azikhala wofunitsitsa, khunyu, kuwonongeka kwa ubongo, kwambiri cerebrosulinosis (kuchuluka mwayi wamagazi osokonezeka ndipo sitiroko), at chachikulu chiwindi / impso ntchitomuukalamba.

Munthawi yamankhwala, tikulimbikitsidwa kupewa ma radiation ya dzuwa ndi dzuwa komanso kuchuluka kwa zochitika zolimbitsa thupi, kuwongolera kuchuluka kwa mkodzo komanso kumwa mankhwala.

Odwala ndi zamkodzo anachita mkodzo, milandu analemba khalid. Popewa kutukuka kwake, ndizosavomerezeka kupitirira muyeso wa mankhwalawa. Kuphatikiza apo, wodwalayo amafunika chakumwa chochulukirapo ndi kukonza mkodzo wa acid.

Kupweteka kwa Tendon ndi zizindikiro tenosynovitis ndi chizindikiro choti muimitse chithandizo, popeza kuti mankhwalawa amachepetsa kapena kupasuka kwa tendon sikutha.

Ciprofloxacin imalepheretsa kuthamanga kwa psychomotor reaction (makamaka motsutsana ndi maziko a mowa), omwe ayenera kukumbukira odwala omwe akugwiritsa ntchito zida zowopsa.

Ndi chitukuko kutsegula m'mimba kwambirisiziyenera kupatulapseudomembranous colitischifukwa matenda ndi contraindication kugwiritsa ntchito mankhwala.

Ngati ndi kotheka, munthawi yomweyo iv ya barbiturates iyenera kuwunika ntchito ya CCC: makamaka, ECG, kugunda kwa mtima, kuthamanga kwa magazi.

Mafuta ophthalmic mawonekedwe a mankhwalawa sanapangidwire jakisoni wambiri.