Insulin isofan > Insulin

"Insulin-isophan" ndi umisiri wa chibadwa cha anthu (Latin Insulinum isophanum humanum biosynt syntum) omwe zochita zake mthupi zimakhala zofanana ndi zachilengedwe ndipo ndi zapakatikati.

Kuphatikizika kwa mankhwalawa kumakhala ndi 1 ml ya magawo zana a mankhwala othandizira, komanso zinthu zina, kuphatikizapo madzi a jakisoni, protamine sulfate, sodium dihydrogen phosphate, crystalline phenol, metacresol ndi glycerol. Kupezeka mu mawonekedwe a kuyimitsidwa. Ili ndi zochitika zotsatirazi:

kumakulitsa lipojiais ndi gluconeogeneis, potero kutsitsa shuga,
kumawonjezera kukoka kwa glucose mwa minofu,
imayendetsa intracellular metabolic process,
kutsitsa glycogen
pambuyo oyamba ayamba kuchita pambuyo 1-1,5 maola,
kugwira ntchito kumakhalabe kwa maola 11 mpaka 24

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Kodi imalembedwa liti?

Zisonyezero zogwiritsidwa ntchito:

Mankhwalawa amalembera azimayi oyembekezera.

lembani 1 ndi matenda ashuga 2
Gawo lomwe thupi limakana mankhwala othandizira odwala matenda a shuga,
lembani matenda ashuga a 2 mwa amayi apakati (posagwirizana ndi zakudya),
kukana pang'ono kwamankhwala ochepetsa shuga ngati mbali yovuta mankhwala,
zovuta za matenda
othandizira opaleshoni (monga gawo la zovuta kapena chithandizo chimodzi).

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Malangizo ogwiritsira ntchito "Insulin-Isophan"

Mankhwalawa amaperekedwa mosavuta, nthawi zina amatha kubayidwa kudzera m'mitsempha. Mlingo wamba patsiku ndi 0,5-1 IU / kg. Mukamachita mankhwalawa, mankhwalawa ayenera kukhala kutentha. Jakisoni amapangidwa nthawi 1-2 pa tsiku kwa mphindi 30-45 musanadye chakudya cham'mawa 8-24 kamodzi. Malo a njirayi amasinthidwa nthawi iliyonse (ntchafu, buttock, khoma lamkati lakumbuyo). Mlingo umasankhidwa payekha, kutengera zofunikira za shuga m'magazi ndi mkodzo, komanso matendawa.

Malangizowo akuwonetsa kuti ana ndi akulu omwe ali ndi hypersensitivity agwiritse ntchito mlingo wa 8 IU, ndipo wotsika kwambiri, amatha kupitilira 24 IU. Odwala omwe apatsidwa ma IU a 100 kapena kuposerapo omwe amathandizidwa ndi mahomoni amayenera kupita kuchipatala. Ngati wodwala akugwiritsa ntchito mankhwala m'malo mwake, shuga wamagazi amayenera kuyang'aniridwa. Malinga ndi malangizo ogwiritsira ntchito, jekeseni wa insulin wa inshuwaransi nthawi yayitali amaletsedwa.

Contraindication

Kuphatikiza pa mikhalidwe yothandiza, mankhwalawa ali ndi zotsutsana:

Hypersensitivity pamagawo a othandizira,
kutsika kwa shuga m'magazi komanso panthawi yapakati,
kukhalapo kwa chotupa cha pancreatic chotsogolera pakupanga kwambiri kwa insulin (insulinoma),
gwiritsani ntchito mosamala odwala opitirira zaka 65 ndikukumana ndi mavuto a chiwindi ndi impso.

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Zotsatira zoyipa

Ngakhale Insulin ndi mankhwala ofunikira kwa odwala matenda ashuga, ali ndi zotsatirazi:

matupi awo sagwirizana ndi urticaria,
kuchepetsa kupanikizika
kutentha kuwonjezeka
Edema ya Quincke ndi anaphylactic,
kumva kuzizira komanso kufupika,
hyperglycemia
Kutupa ndi kuyabwa pa malo a jekeseni
kuwonongeka kwamawonekedwe,
kumverera kwa mantha ndi njala, kusowa tulo, kukhumudwa ndi ena.

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Kugwirizana

Pali mankhwala omwe amalimbikitsa mphamvu za "Insulin-isophan" akaperekedwa limodzi, awa ndi awa:

othandizira a hypoglycemic mapiritsi,
monoamine oxidase zoletsa, angiotensin kutembenuza enzyme, NSAIDs,
sulfamides,
maantibayotiki amodzi
mankhwala othandizira,
mankhwala ochizira matenda oyamba ndi fungus,
Theophylline ndi Clofibrate
mankhwala omwe ali ndi lithiamu.

Amachepetsa mphamvu ya chikonga cha mankhwala, mowa umalimbitsa mphamvu ya hypoglycemic.Palinso mankhwala omwe amakhudza kupititsa patsogolo ndi kuchepa kwa mphamvu ya "Insulin-isofan" - awa ndi β-blockers, "Reserpine", "Pentamidine". Mankhwala omwe amachepetsa vutoli akuphatikizapo:

mahomoni a chithokomiro komanso adrenal cortex,
Heparin
okodzetsa
antidepressants
Danazol ndi Morphine
kulera kwamlomo.

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Zizindikiro zochuluka

Ngati bongo wambiri wa othandizira amachitika, kusintha mu malingaliro kumatha kuchitika, komwe kumawonetsedwa ndi mantha, kukhumudwa, kusakwiya, chikhalidwe chachilendo. Komanso kupezeka kwa hypoglycemia - kuchepa kwa shuga m'magazi. Amathandizidwa ndikuyang'anira dextrose kapena glucagon. Pankhani ya kukomoka kwa hypoglycemic, dextrose amaperekedwa kwa wodwala mpaka mkhalidwe umakhazikika. Kenako zakudya zapamwamba zamkati zimalimbikitsidwa.

Njira zopewera kupewa ngozi

Pamaso jakisoni, muyenera kuonetsetsa kuti yankho ndi lomveka, popanda chipwirikiti. Ndi mawonekedwe a ma flakes, amtambo, matope, mankhwalawo saloledwa kugwiritsa ntchito. Ngati wodwala akudwala chimfine kapena matenda ena opatsirana, tikulimbikitsidwa kukaonana ndi dokotala za mlingo. Kutentha kwa mankhwalawa musanabayidwe jakisoni. Ndikofunikira nthawi zonse kusintha gawo la jekeseni.

Mitu ya mankhwalawa

Kugwiritsira ntchito m'malo mwa mankhwalawa kuyenera kuvomerezedwa ndi adokotala, chifukwa mahomoni ndi mankhwala akuluakulu omwe angayambitse kusakhudzidwa kosafunikira. The analogues of Insulin-Isophan adapangidwa, omwe ali ndi dzina lamalonda Insumal, Humulin, Biogulin, Pensulin, Insulidd, Gensulin, Aktrafan, Vozulim ndi ena. Mankhwala osokoneza bongo kwa wodwala amatha kuikidwa kokha ndi dokotala potengera kapangidwe kake, komanso mlingo, womwe umasankhidwa payekha.

Chidziwitsocho chimaperekedwa kuti chizidziwitso chokha chokha ndipo sichingagwiritsidwe ntchito pakudzipangira nokha mankhwala. Osadzinyengerera, zitha kukhala zowopsa. Nthawi zonse funsani dokotala. Pofuna kukopera mwatsatanetsatane kapena mwatsatanetsatane zinthu zomwe zili pamalowo, kulumikizana kwofunikira kukufunika.

Isofan insulin: malangizo ogwiritsira ntchito komanso mtengo wa mankhwalawa

Chithandizo cha insulini chili ndi mawonekedwe enaake, chifukwa ntchito yayikulu yothandizira ndi kulipirira zolakwika mu chakudya cha metabolism mwa kuyambitsa mankhwala apadera pansi pa khungu. Mankhwala oterowo amakhudza thupi komanso insulini yachilengedwe yopangidwa ndi kapamba. Pankhaniyi, mankhwalawa amakhala athunthu kapena osapatula.

Mwa mankhwala omwe amagwiritsidwa ntchito popanga matenda ashuga, imodzi mwabwino ndi insulin Isofan. Mankhwala ali ndi chibadwa chomanga insulin ya nthawi yayitali.

Chidachi chimapezeka m'njira zosiyanasiyana. Amayendetsedwa m'njira zitatu - subcutanely, intramuscularly komanso kudzera m'mitsempha. Izi zimathandiza wodwala kusankha njira yabwino kwambiri yolamulirira glycemia.

Zizindikiro zogwiritsidwa ntchito ndi mayina ogulitsa a mankhwalawa

Kugwiritsa ntchito mankhwalawo kumasonyezedwa ngati mtundu wa shuga womwe umadalira insulin. Komanso, chithandizo chamankhwala chiyenera kukhala moyo wonse.

Insulin monga Isofan ndi mankhwala opangidwa ndi chibadwa cha anthu omwe amalembedwa mu milandu yotere:

mtundu 2 shuga (wodalira insulin),
opaleshoni njira
kukana hypoglycemic wothandizila kumwa pakamwa monga mbali ya zovuta mankhwala,
matenda a shuga (osagwiritsa ntchito mankhwalawa),
pafupipafupi matenda.

Makampani opanga mankhwala amapanga insulin yaumunthu yopangidwa ndi mayina osiyanasiyana. Odziwika kwambiri ndi Vozulim-N, Biosulin-N, Protafan-NM, Insuran-NPH, Gensulin-N.

Mitundu ina ya isofan insulin imagwiritsidwanso ntchito ndi awa:

Wopanda pake
Humulin (NPH),
Pensulin,
Isofan insulin NM (Protafan),
Actrafan
Insulidd N,
Biogulin N,
Chitetezo cha Protafan-NM.

Ndikofunikira kudziwa kuti kugwiritsa ntchito tanthauzo lililonse la Insulin Isofan kuyenera kuvomerezana ndi adokotala.

Zotsatira za pharmacological

Insulin yamunthu imakhala ndi vuto la hypoglycemic. Mankhwala amalumikizana ndi ma membrane a cell a cytoplasmic, ndikupanga insulini-receptor. Imayendetsa njira zomwe zimapezeka mkati mwa maselo ndikupanga ma enzymes akuluakulu (glycogen synthetase, pyruvate kinase, hexokinase, etc.).

Kuchepetsa kuchuluka kwa shuga kumachitika ndikuwonjezera mayendedwe ake amkati, kutsitsa kuchuluka kwa shuga ndi chiwindi, zomwe zimapangitsa kuti mayamwidwe ndikupitikitsanso shuga ndi minyewa. Komanso, insulin yaumunthu imayendetsa kaphatikizidwe wa mapuloteni, glycogenogeneis, lipogeneis.

Kutalika kwa mankhwala kumadalira kuthamanga kwa mayamwidwe, ndipo chifukwa cha zinthu zosiyanasiyana (dera la kayendetsedwe, njira ndi mlingo). Chifukwa chake, mphamvu ya Isofan insulin ikhoza kusefukira mwa odwala komanso odwala matenda ashuga.

Nthawi zambiri pambuyo pa jekeseni, mphamvu ya mankhwalawa imadziwika pambuyo pa maola 1.5. Chiwonetsero chachikulu kwambiri pakugwira bwino ntchito kumachitika maola 4-12 pambuyo pa makonzedwe. Kutalika kwa chochitika - tsiku limodzi.

Chifukwa chake, kuperekera kwathunthu ndi kuyambika kwa ntchito kwa wothandizirazi zimatengera zinthu monga:

dera la jakisoni (matako, ntchafu, pamimba),
yogwira mankhwala ndende
Mlingo.

Kukonzekera kwa insulin kwa anthu kumagawidwa mosiyanasiyana mu minofu. Samalowa m'matumbo ndipo samayamwa mkaka wa m'mawere.

Amawonongedwa ndi insulinase makamaka mu impso ndi chiwindi, omwe amawonjezera kuchuluka kwa 30-80% ndi impso.

Mlingo ndi makonzedwe

Malangizo ogwiritsidwira ntchito ndi insulin Izofan akuti amathandizira kawiri kawiri patsiku musanadye kadzutsa. Pankhaniyi, muyenera kusintha jakisoni tsiku lililonse ndikusunga syringe yomwe imagwiritsidwa ntchito kutentha kwa chipinda, ndi yatsopano mufiriji.

Nthawi zina mankhwala kutumikiridwa intramuscularly. Ndipo njira yolowerera yogwiritsira ntchito insulin yomwe imagwiritsa ntchito siigwiritsidwa ntchito.

Mlingo amawerengedwa payekhapayekha kwa wodwala aliyense, potengera kuchuluka kwa kuchuluka kwa shuga m'magazi achilengedwe komanso kutengera kwa matendawa. Monga lamulo, avareji ya tsiku ndi tsiku imachokera ku 8-24 IU.

Ngati odwala ali ndi insulin, ndiye kuti tsiku lililonse mankhwalawo ndi 8 IU. Ndi chiwopsezo chovuta cha mahomoni, mlingo umawonjezeka - kuyambira 24 IU patsiku.

Ngati kuchuluka kwa mankhwalawa tsiku lililonse kumaposa 0,6 IU pa 1 makilogalamu, ndiye kuti jakisoni awiri amapangidwa mbali zosiyanasiyana za thupi. Odwala omwe ali ndi tsiku lililonse la 100 IU kapena kuposerapo ayenera kugonekedwa m'chipatala ngati insulin italowedwa m'malo.

Komanso, posamutsa kuchokera ku mtundu wina wamtundu kupita ku wina, ndikofunikira kuwunika zomwe zili ndi shuga.

Insulin

Mayina amalonda a chibadwa cha insulin isofan ya anthu ndi Biosulin-N, Vozulim-N, Gensulin-N, Insuran-NPH, Protafan-NM, etc.
Nthawi zina, mutha kuyika mitundu ya insulin Isofan ndi mayina amalonda:

Mulingo uliwonse wotenga mawu ofananira a Insulin Isofan uyenera kuvomerezedwa ndi akatswiri.

Zochita za insulin

Kuchita kwa genetically insulin isophane yamtundu wautali ndi yayitali. Moyenerera amachepetsa kuchuluka kwa shuga m'magazi, komanso kukonza kuyamwa kwa zinthuzi ndi minyewa ya thupi la munthu. Mothandizidwa ndi anthu okhala ndi majini amtundu wa Insulin Isofan, lipogeneis, gluconeogenesis amathandizidwa, ndipo kuchuluka kwa chinthu m'chiwindi kumachepa.

Mankhwala opangidwa ndi jini amalumikizana ndi cholandirira chomwe chimadalira insulini ku membrane wakunja kwa cell. Chifukwa cha izi, insulin-receptor tata imayambitsa. Imayendetsa njira zambiri zomwe zimachitika m'maselo, chifukwa cha kupangika kwa cAMP mu hepatocytes ndi maselo amafuta. Mapangidwe a ma enzymes - hexo-kinases, pyruvate kinases, glycogen synthetases - imathandizira kwambiri.Mankhwala opangidwa mwabadwa amatha kukhala ndi zotsatira zabwino pakupanga mapuloteni.

Zochitazo pambuyo subcutaneous makina ophatikizika amtundu wa insulin amayamba mu ola limodzi ndi theka. Zochita zapamwamba za mankhwalawa zimachitika pambuyo pa maola 4 mpaka 12 (kutengera mlingo, komanso umunthu wa munthu aliyense). Kuchuluka kwakukulu (kuyambira maola 11 mpaka 24) kumadaliranso izi.

Ngakhale kuti insulin ndiyofunikira kwa odwala matenda ashuga (makamaka pamilandu ya matendawo omwe amadalira insulin), komabe siikhala ndi zotsatirapo zoyipa. Mwa iwo, malangizo ogwiritsira ntchito akuwonetsa.

Matupi omaliza. Nthawi zambiri pamakhala urticaria, angioedema. Kuwonetsedwa ndi kutentha ndi kugwa kwakuthwa m'magazi.
Kutsitsa shuga wamagazi (hypoglycemia). Amawonetsedwa ndi khungu la pakhungu, mawonekedwe a kumverera kwanjala, kuchuluka kwa pafupipafupi mtima, kugona, mantha komanso chikhalidwe chosayenera. Milandu yayikulu imayamba.
Ngati muphonya jakisoni, mutha kudwala matenda ashuga a shuga (pamenepa, pamakhala kugona, polydipsia, kutuluka kwa nkhope).
Kumayambiriro kwa mankhwala amtunduwu wa insulin, kuwonongeka kwa kuthekera ndikotheka. Izi zikuchitika posachedwa.
Zokhudza immunological. Nthawi zambiri, amakhalanso osakhalitsa.
Khungu loyera, redness.
Kuwonongeka kwa kukonzanso khungu, kumawonedwa nthawi zambiri kumayambiriro kwa chithandizo.
Ndi bongo wambiri, kusintha kwa malingaliro kumawonedwa. Mantha, kukhumudwa, kusakwiya, zochitika zachilendo ndizofunikira.

Chithandizo cha hypoglycemia, chomwe nthawi zambiri chimachitika ndi mankhwalawa, ndi kukhazikitsa dextrose, glucagon. Ndi hypoglycemic coma, dextrose amaperekedwa kwa wodwala mpaka zizindikilo za vutoli zidapita.

Ndikofunikira kuphunzira malangizo ogwiritsira ntchito Insulin Isofan. Musanayendetse Isofan, wopanga ma insulin, mwanjira ina, ndikofunikira kuyang'ana botolo ndi mtundu wa mankhwalawo kuti mankhwala olakwika asaperekedwe molakwika. Ngati matupi achilendo atapezeka, yankho lake limakhala lamitambo, makamaka ngati chiwongola dzanja chikuwoneka pagalasi la botolo, ndiye kuti mankhwalawo sayenera kugwiritsidwa ntchito mulimonsemo - amatha kukhala oopsa kwa wodwalayo.

Muyenera kuwonetsetsa kuti kutentha kwa mankhwalawo ndi kutentha kwa chipinda.
Onetsetsani kuti mwasintha kuchuluka kwa mankhwalawa chifukwa cha matenda opatsirana, matenda a chithokomiro, matenda a Addisson, komanso hypopituitarism. Komanso, mlingo wa insulin umakhudzidwa pakuwonetsedwa kwa kulephera kwa aimpso komanso mwa anthu omwe adutsa zaka 65.

Nthawi zina hypoglycemia imatha kuchitika ngati wodwalayo asintha gawo la jekeseni (mwachitsanzo, kuchokera pakhungu la pamimba kupita pakhungu la ntchafu). Hypoglycemia imachitikanso ngati dokotalayo amachotsa wodwala kuchokera ku insulin ya chinyama kupita ku mankhwala ofanana ndi a munthu. Odwala onse amatha kupewa kuyambika kwa hypoglycemia kuyambira chakudya chamagulu (chifukwa pamenepa muyenera kukhala ndi shuga osachepera 20 g).

Ndi chizolowezi cha hypoglycemia, simuyenera kuyendetsa galimoto kapena kugwira ntchito ndi zida zomwe zimafuna kuti munthu azilabadira kwambiri. Pa mankhwala, mowa saloledwa.

Kuchita ndi mankhwala ena

Mankhwala osokoneza bongo monga sulfonamides, ma inhibitors a MAO, ma inhibitors a ACE, mankhwala omwe si a antiidal amapititsa patsogolo shuga. Mowa wambiri umathandizanso kudziwa mphamvu ya hypoglycemic, yomwe imayenera kuganiziridwa nthawi zonse mukamapatsa insulin.

Mankhwala osokoneza bongo monga glucagon, somatotropin, diuretics (loopback, komanso thiazides), Clonidine hydrochloride, Danazole, Morphine, komanso chamba ndi chikonga zimafooketsa mphamvu yotsitsa shuga. Ndiosafunika kusuta panthawi ya insulin, chifukwa kuchuluka kwa glycemia kumachepetsa mphamvu ya mankhwalawa.

Isofan insulin imagawidwa kwa ogula pokhapokha ngati amupatsa mankhwala. Kudzipatsa nokha mankhwala sikuloledwa. Ndi koletsedwa konse kugwiritsa ntchito insulin yotereyi itatha moyo wa alumali.Osamamwa mankhwalawo ngati atha mu botolo lotseguka.

Njira yogwiritsira ntchito

P / C, katatu patsiku, mphindi 30-45 musanadye kadzutsa (sinthani malo a jekeseni nthawi iliyonse). Mwapadera, adokotala amatha kukupatsani jakisoni wa / m mankhwala. Mu / pakubweretsa insulin ya sing'anga nthawi yoletsedwa! Mlingo amasankhidwa payekha ndipo zimatengera zomwe zili ndi shuga m'magazi ndi mkodzo, mawonekedwe a matendawa. Nthawi zambiri, Mlingo ndi 8-24 IU 1 nthawi patsiku. Akuluakulu ndi ana omwe ali ndi chidwi chachikulu ndi insulin, mlingo wochepera 8 IU / tsiku ukhoza kukhala wokwanira, mwa odwala omwe ali ndi chidwi chokwanira - oposa 24 IU / tsiku. Pa mlingo wa tsiku lililonse wopitilira 0,6 IU / kg, - wofanana ndi jakisoni 2 m'malo osiyanasiyana. Odwala omwe amalandila 100 IU kapena kuposerapo patsiku, akachotsa insulin, ndikofunika kuchipatala. Kusamutsa kuchokera ku mankhwala kupita ku wina kuyenera kuchitika mothandizidwa ndi shuga wamagazi.

Mtundu woyamba wa matenda a shuga 1 a mtundu wa 2 matenda a shuga )

Zotsatira zoyipa

Thupi lawo siligwirizana (urticaria, angioedema - malungo, kufupika, kutsika magazi), hypoglycemia (pallor of the khungu, thukuta lakuchuluka, thukuta, kutukwana, kugwedezeka, njala, kukalamba, nkhawa, kupweteka kwa pakamwa, kupweteka mutu, kugona, kugona, kugona mantha, kukhumudwitsa, kusakwiya, zosazolowereka, kusayenda bwino kwa kayendedwe, malankhulidwe ndi masomphenya), hypoglycemic coma, hyperglycemia and diabetesic acidosis (pamiyeso yochepa, jakisoni wambiri, kulephera kutsatira kadyedwe, e fever ndi matenda): kugona, ludzu, kuchepa kwa chakudya, nkhope yakuwonekera), kusokonezeka kwa chikumbumtima (mpaka kukhazikika kwa chikomokere), kuwonongeka kwapang'onopang'ono (nthawi zambiri kumayambiriro kwa mankhwala), kugwiritsidwa ntchito kwa immunological ndi insulin ya anthu, kuchuluka kwa anti-insulin antibodies ndi kuwonjezeka kwa glycemia, hyperemia, kuyabwa ndi lipodystrophy (atrophy kapena hypertrophy of subcutaneous fat) m'malo a jekeseni. Kumayambiriro kwa mankhwalawa - kutupa ndi kusokonezeka komwekonso (kumakhala kwakanthawi ndipo kumazimiririka ndi chithandizo chopitilira). Zizindikiro: thukuta, thukuta, kugwedezeka, kugona, nkhawa, kupsinjika mkamwa, pallor, mutu, kugona, kusowa tulo, mantha, kupsinjika, kusakhazikika, kusazolowereka, kusayenda, kuyankhula komanso kuwona, hypoglycemic chikomokere, kukomoka. Chithandizo: ngati wodwalayo akudziwa, dextrose amalembedwa pakamwa, s / c, iv kapena iv pakamwa jekeseni kapena iv hypertonic dextrose solution. Ndikupanga chikomokere cha hypoglycemic, 20-40 ml (mpaka 100 ml) wa 40% dextrose solution amawayilowetsa mu mtsinje mpaka wodwala atatuluka.

Kutulutsa Fomu

Kuyimitsidwa kwa jakisoni mu Mbale 10 ml (40, 80 ndi 100 IU kapena IU mu 1 ml).

Zomwe zili patsamba lomwe mukuwona zimapangidwa kuti zidziwitso zokha komanso sizimalimbikitsa kudzipatsa mankhwala mwanjira iliyonse. Chidacho chimapangidwa kuti chizolowere akatswiri azachipatala kuti awonjezere zambiri zamankhwala ena, potero amawonjezera luso lawo. Kugwiritsa ntchito mankhwala "Isofan insulin "mosakayikira imapereka mwayi wothandizidwa ndi katswiri, komanso malingaliro ake pa njira yogwiritsira ntchito ndi mlingo wa mankhwala omwe mwasankha.

Fomula, dzina la mankhwala: palibe deta.
Gulu lamagulu: mahomoni ndi okana / ma insulin.
Machitidwe hypoglycemic.

Mankhwala

Mankhwalawa amapangidwa ndi recombinant DNA biotechnology pogwiritsa ntchito mtundu wa Saccharomyces cerevisiae. Mankhwala, omwe amalumikizana ndi ma membrane ena a kunja kwa cell ya cell, amapanga insulin receptor zovuta zomwe zimapangitsa kuti ma cell azikhala mkati mwa cell, kuphatikiza kupanga ma enzyme ena ofunikira (pyruvate kinase, hexokinase, glycogen synthetase ndi ena). Kuchepa kwa kuchuluka kwa shuga m'magazi kumachitika chifukwa cha kuchuluka kwa mayendedwe ake mkati mwa maselo, kuchulukitsa ndikumwedwa ndi minyewa, komanso kuchepa kwa mapangidwe a shuga m'magazi. Mankhwala amathandizira glycogenogeneis, lipogenesis, kaphatikizidwe kazinthu kena.
Kutalika kwa chochita cha mankhwalawa makamaka chifukwa cha kuperewera kwake, kutengera mtundu wake, malo ake ndi njira yake yoyendetsera zinthu zina, chifukwa chake, mawonekedwe amomwe mankhwalawo amatha kusiyanasiyana osati mwa odwala osiyanasiyana, komanso mwa munthu yemweyo. Pafupifupi, ndi subcutaneous makonzedwe a mankhwalawa, kuyamba kwa chochitika kumachitika pambuyo pa maola 1.5, mphamvu kwambiri imatheka pambuyo pa maola 4 mpaka 12, nthawi yochita mpaka tsiku. Kukhazikika kwa vutoli komanso kukwaniritsidwa kwa mankhwala kumadalira mlingo (kuchuluka kwa mankhwala omwe amaperekedwa), tsamba la jekeseni (ntchafu, m'mimba, matako), kuchuluka kwa insulin pamankhwala, ndi zina. Kuchuluka kwa insulini m'madzi a m'magazi kumafikiridwa patatha maola 2 mpaka 18 pambuyo pochita zinthu zina. Palibe zomangamanga zomanga mapuloteni a plasma zimadziwika, kupatula kuzungulira kwa ma antibodies kupita ku insulin (ngati alipo). Mankhwalawa amagawidwa mosiyanasiyana mu minyewa yonse, samalowa mkaka wa m'mawere kudzera mu chotchinga chachikulu. Kwambiri mu impso ndi chiwindi, mankhwalawa amawonongedwa ndi insulinase, komanso, mwina, mapuloteni disulfide isomerase. Ma insulin metabolites sagwira ntchito. Hafu ya moyo wa insulini kuchokera m'magazi ndi mphindi zochepa chabe. Kuchotsa hafu ya moyo kuchokera ku chamoyo kumapangitsa pafupifupi maola 5 - 10. Amachotsa impso (30 - 80%).
Palibe chiwopsezo chenicheni cha mankhwalawa kwa anthu chomwe chidawululidwa panthawi yophunzira zamakedzana, zomwe zimaphatikizapo maphunziro a kawopsedwe okhala ndi dosing yowonjezera, maphunziro a chitetezo pamatenda, maphunziro a carcinogenic omwe angapangidwe, genotoxicity, ndi zotsatira zoyipa pakubala.

Type 1 shuga mellitus, mtundu 2 shuga mellitus: kukana pang'ono kwa mankhwala a hypoglycemic (panthawi yophatikiza mankhwala), gawo la kukana kwa mankhwala amkamwa a hypoglycemic, matenda amiseche, mtundu wa 2 matenda a shuga.

Zochita Zosiyanasiyana

Kugwiritsa ntchito insulin yaumunthu kumatha kuyambitsa matupi awo. Nthawi zambiri, ndi angioedema (hypotension, kupuma movutikira, malungo) ndi urticaria.

Komanso, kupitilira muyeso kungayambitse hypoglycemia, yowonetsedwa ndi zizindikiro zotsatirazi:

kusowa tulo
chikopa,
kukhumudwa
hyperhidrosis
mantha
dziko lokondwa
kugunda kwa mtima
mutu
chisokonezo,
Vuto lama vestibular
njala
kugwedezeka ndi zinthu.

Zotsatira zoyipa zimaphatikizira diabetesic acidosis ndi hyperglycemia, zomwe zimawonetsedwa ndi kutulutsa nkhope, kugona, kusowa kudya komanso ludzu. Nthawi zambiri, mikhalidwe yotere imachitika motsutsana ndi maziko a matenda opatsirana komanso kutentha thupi, jekeseni ikaphonya, mulingo wake sukulondola, ndipo ngati zakudya sizitsatiridwa.

Nthawi zina kuphwanya kwa chikumbumtima kumachitika. Pamavuto, pamakhala mkhalidwe wovuta komanso wamakhalidwe.

Kumayambiriro kwa mankhwalawa, kusokonezeka kwa nthawi yochepa kumatha kuchitika. Kuwonjezeka kwa gawo la anti-insulin matupi kumadziwikanso ndi kupita patsogolo kwa glycemia komanso zochita zamagetsi zamtundu wa mtanda ndi insulin ya anthu.

Nthawi zambiri tsamba la jakisoni limatupa ndikuluma.Poterepa, mafuta onunkhira a minyewa kapena ma atrophies. Ndipo pa gawo loyambirira la zamankhwala, zolakwika zosakhalitsa ndi edema zimatha.

Ngati mankhwala osokoneza bongo ochulukirapo, shuga m'magazi amatsika kwambiri. Izi zimayambitsa hypoglycemia, ndipo nthawi zina wodwala amagwa.

Ngati mulingo wachepera, muyenera kumwa zakudya zamatumbo ambiri (chokoleti, mikate yoyera, mpukutu, maswiti) kapena kumwa chakumwa chokoma kwambiri. Pakukomoka, yankho la dextrose (40%) kapena glucagon (s / c, v / m) limaperekedwa kwa wodwala mu / mu.

Wodwala akayambanso kudziwa bwino, ndikofunikira kumudyetsa chakudya chamafuta ambiri.

Kuyimitsidwa kwa oyang'anira sc sikugwiritsidwa ntchito ndi njira zina zamankhwala ena. A Co-makonzedwe ndi sulfonamides, Ace / Mao / carbonic anhydrase, NSAIDs, Mowa zoletsa, anabolic mankhwala, ndi chloroquine, androgens, kwinini, bromocriptine, pirodoksin, tetracyclines, kukonzekera lifiyamu, clofibrate, fenfluramine, Ketonozolom, Tsiklofosvamidom, theophylline, mebendazole Angathe hypoglycemic kwenikweni.

Kufooka kwa hypoglycemic zochita kumapangitsa:

H1 histamine receptor blockers,
Glucagon
Somatropin
Epinephrine
Phenytoin
kulera kwamlomo
Epinephrine
Ma estrogens
odana ndi calcium.

Kuphatikiza apo, kuchepa kwa shuga kumayambitsa kugwiritsidwa ntchito kophatikizana kwa Isofan insulin yokhala ndi loopide ndi thiazide diuretics, Klondin, BMKK, Diazoxide, Danazol, mahomoni a chithokomiro, ma tridclic antidepressants, sympathomimetics, Heparin ndi sulfinpyrazone. Nikotini, chamba ndi morphine zimakulitsanso hypoglycemia.

Pentamidine, beta-blockers, Octreotide ndi Reserpine angalimbikitse kapena kufooketsa glycemia.

Njira zopewera kugwiritsidwa ntchito kwa Isofan insulin ndikuti munthu wodwala matenda ashuga asinthidwe malo omwe jakisoni wa insulin adzaperekedwe. Kupatula apo, njira yokhayo yolepheretsa kuwoneka kwa lipodystrophy.

Poyerekeza ndi maziko a mankhwala a insulin, muyenera kuyang'anira kuchuluka kwa shuga. Kuphatikiza pa kugwirira ntchito limodzi ndi mankhwala ena, zinthu zina zimayambitsa hypoglycemia:

ndi kusanza
m'malo mankhwala
matenda omwe amachepetsa kufunika kwa mahomoni (aimpso ndi chiwindi kulephera, kuchepa kwa chithokomiro, chithokomiro cha pituitary, etc.),
Zakudya zosadziwika,
kusintha kwa jekeseni.

Mlingo wosalondola kapena kupumira kwakatikati pakati pa jakisoni wa insulin kungathandize kukulitsa hyperglycemia, makamaka ndi matenda a shuga 1. Ngati chithandizo sichinasinthidwe mu nthawi, ndiye kuti wodwala nthawi zina amakhala ndi vuto la ketoacidotic.

Kuphatikiza apo, kusintha kwa mlingo kumafunika ngati wodwalayo akuposa zaka 65, ndiye kuti wasokonekera kugwira ntchito kwa chithokomiro, impso kapena chiwindi. Ndikofunikira pa hypopituitarism ndi matenda a Addison.

Kuphatikiza apo, odwala ayenera kudziwa kuti kukonzekera kwa insulin ya anthu kumachepetsa kulolera. M'migawo yoyambirira yamankhwala, pakakhala njira yothetsera vutoli, kupanikizika, kulimbitsa thupi mwamphamvu, sikofunikira kuyendetsa galimoto komanso njira zina zovuta kapena kuchita nawo zinthu zoopsa zomwe zimafuna kuwonjezeredwa chidwi komanso kuthamanga.

Odwala omwe ali ndi pakati ayenera kuganizira kuti m'nthawi yoyambirira kufunikira kwa insulin kumachepa, ndipo mu 2 ndi 3 kumawonjezeka. Komanso mahomoni ocheperako amatha kufunikira ntchito.

Mankhwala a Isofan afotokozeredwa mu kanema munkhaniyi.

Matenda a shuga ndi matenda omwe sangathe kuchiritsidwa kwathunthu. Madokotala amalimbikitsa kukonzekera koyenera "Insulin-isofan", komwe kuyimitsidwa kochepa pakupanga khungu. Amasankhidwa kuti azilamulira shuga wamagazi ndikusintha njira zogwirira ntchito m'thupi. Itha kugwiritsidwa ntchito pochiza kwathunthu komanso pang'ono.

Kutulutsa mafomu, mtengo wake

Mankhwala amapezeka poyimitsa.Cholinga chake ndi kayendetsedwe ka subcutaneous. Mankhwalawa amakhala ndi nthawi yokwanira kuchitapo kanthu. Nthawi yomweyo, amachepetsa kuchuluka kwa glucose m'magazi ndikuwathandizira kuti azitha kulowa mu minofu. Imathandizira njira ya kaphatikizidwe wa mapuloteni, glycogenogeneis ndi lipogeneis.

Nthawi ya insulin ntchito zimatengera zizindikiro zina:

kuchuluka kwa kuyamwa
Mlingo wa makonzedwe
tsamba la jakisoni ndi ena ambiri ena

Kutalika kwa mankhwalawa ndi kosiyana mwa anthu osiyanasiyana komanso mwa munthu m'modzi. Pafupifupi, kuyambika kwa mankhwala ndi subcutaneous makonzedwe ndi ola limodzi ndi theka. Kuti mukwaniritse kwambiri muyenera kutenga maola 4 mpaka 12. Ndipo nthawi yayitali yogwiritsira ntchito mankhwalawa ndi tsiku limodzi.

Nthawi ya kuyambika, komanso kuperewera kwa mayamwa kumadalira mwachindunji kuchuluka kwa mankhwalawa omwe amaperekedwa ndi komwe adapereka. Kuphatikiza apo, kugwiritsidwa ntchito kwa mankhwalawa ndi zinthu zina zambiri ndizothandiza kwambiri. Mutha kulowa mankhwalawa m'mimba, matako ndi ntchafu.

Kuchuluka kwa insulini m'magazi, molondola kwambiri m'madzi a m'magazi, amasonkhana kuyambira maola 2 mpaka 18 kuyambira nthawi ya jakisoni. Pankhaniyi, insulin sichigwirizana ndi mapuloteni. Kugawa kwake m'thupi lathu lonse sikofanana. Mankhwalawa samadutsa mkaka wa m'mawere, komanso kudzera pazotchinga kuchokera ku placenta.

Zimangotenga mphindi zochepa kuti muchotse magaziwo, koma kuti achotse thupi, amachotsedwa maola 5 mpaka 10. Impso zimachotsa mpaka 80%. Pochita kafukufuku, palibe chowopsa chomwe chidapezeka m'thupi. Malangizo ogwiritsira ntchito mankhwalawa ndi ochuluka kwambiri. Imafotokoza bwino magawo onse a pulogalamuyi.

Zizindikiro ndi contraindication

Monga mankhwala ena aliwonse, mainjiniya a insulin "Isofan" aumunthu ali ndi zisonyezo zakugwiritsa ntchito. Yoyamba mwa izi ndi matenda ashuga 1. Chachiwiri ndi matenda ashuga amitundu iwiri pamankhwala osiyanasiyana. Mankhwalawa amatha kutengedwa mukakhala ndi pakati.

Palibe zoletsa. Simungasiye kumwa mankhwalawa ndikuyamwitsa. Kupatula apo, mankhwalawa samalowa mkaka wa m'mawere ndi placenta. Ngati, komabe, pali kufunitsitsa kukana kumwa mankhwalawo, ndiye kuti ndikofunikira kukumbukira kuti nthawi yomweyo matenda amatha kupanga momwe angavulaze kukula kwa mwana wosabadwayo. Izi zitha kuchititsa kuti mwana ayambe kubadwa popanda vuto kapena kumwalira.

Mukanyamula mwana, musanyalanyaze kupita ku madokotala. Potere, kuyang'anira kuchuluka kwa glucose ndikofunikira. Panthawi yakukonzekera kutenga pakati, muyenera kutsatira malangizo onse omwewa.

Kufunika kwa insulin kumakhala kocheperako mu trimester yoyamba, ndipo kumawonjezeka kwambiri panthawi yotsatira. Pambuyo pobala, kufunika kwa insulini kumakhalabe chimodzimodzi monga momwe kunaliri asanatenge pathupi. Pa mkaka wa m`mawere, m`pofunika kusintha mlingo wa mankhwala ndi zakudya.

Inde, ndipo ,achidziwikire, mankhwalawa ali ndi contraindication. Loyamba mwa izi lidzakhala hypersensitivity ku zigawo za mankhwala. Kutsutsana kwachiwiri ndikutembenuka kosalekeza kuchokera ku chizolowezi, chomwe chimadziwika ndi kuchepa kwa glucose omwe ali m'mitsempha yamagazi m'munsi mwa 3.5 mmol / L. Mtsutso wachitatu ndi insulinoma.

Ndi subcutaneous makonzedwe, mlingo umatsimikiziridwa ndi dokotala mwachindunji kwa wodwala aliyense payekhapayekha. Mulingo uliwonse umaganiziridwa, chifukwa kuchuluka kwa insulin kosiyanasiyana kumasiyana pakati pa 0,5 ndi 1 IU / kg. Mlingo uwu umatengera kuchuluka kwa glucose m'magazi a wodwala komanso machitidwe a aliyense wa iwo. Ichi ndichifukwa chake kuwerengera molondola kwa manambala kumafunika.

Kwa jakisoni, odwala ambiri amakonda kusankha m'chiuno. Malo ena atha kukhala khoma lakutsogolo kwamkati wam'mimba, malo amapewa ndi matako. Asanayambe makonzedwe, amafunikira kutentha mankhwalawa firiji.

Kukhazikitsa kwa mankhwala kumatheka pokhapokha. Palibe chifukwa muyenera kuperekera mankhwalawa.

Kufunika kozama kwa insulin kumawonekera mwa anthu onenepa kwambiri komanso nthawi yakutha msinkhu. Sitikulimbikitsidwa kupereka mankhwalawo pamalo omwewo. Majekeseni onse ayenera kuchitidwa m'malo osiyanasiyana mkati mwa malo ovomerezeka.

Pogwiritsa ntchito insulin, kuyang'anira kuchuluka kwa shuga m'magazi kumafunika. Nthawi yomweyo, musaiwale za kufunika kwakudya kwakanthawi. Sikoyenera kuchita m'malo mwamankhwala osavomerezeka ndi dokotala.

Mu matenda a impso ndi chiwindi, kufunika kwa insulin kumachepetsa kwambiri. Ntchito yolakwika ya chithokomiro ingayambitse zotsatira zomwezo.

Ulendo wokhudzana ndikusintha nyengo uyenera kuvomerezedwa ndi dokotala. Cholinga cha izi ndizosavuta. Mukamasintha nthawi, nthawi yakudya komanso mankhwala asintha.

Ngakhale mukumwa mankhwalawo, makamaka poyambira, akhoza kuchepa mphamvu yakuyendetsa galimoto ndi magalimoto ena.

Mankhwalawa ali ndi mitundu yambiri ya ma analogu, koma kuti muwazindikire pamahelufu azamankhwala, muyenera kudziwa dzina la malonda la insulin "Isofan":

Amasankhidwa kuti azilamulira shuga wamagazi ndikusintha njira zogwirira ntchito m'thupi. Itha kugwiritsidwa ntchito pochiza kwathunthu komanso pang'ono.

Mimba komanso kuyamwa

Palibe choletsa kugwiritsa ntchito insulin panthawi yomwe mukukhala ndi pakati komanso poyamwitsa, popeza insulin simalowa m'matumbo komanso kulowa mkaka wa m'mawere. Hypoglycemia ndi hyperglycemia, yomwe imatha kukhala ndi chithandizo chosankhidwa bwino, imakulitsa chiopsezo cha kufa kwa fetal komanso maonekedwe a fetal. Amayi oyembekezera omwe ali ndi matenda ashuga amayenera kuyang'aniridwa ndi madokotala panthawi yonse yokhala ndi pakati, ayenera kuyang'anitsitsa kuchuluka kwa shuga wamagazi, ndipo malingaliro omwewo amagwiranso ntchito kwa amayi omwe akukonzekera kutenga pakati. Mu trimester yoyamba ya mimba, insulin amafuna nthawi zambiri imachepa ndipo pang'onopang'ono imachulukirachulukira kwachiwiri komanso kwachitatu. Pambuyo pa kubala, kufunikira kwa insulin nthawi zambiri kumabweza msanga pamlingo womwe umawonedwa asanakhale ndi pakati. Nthawi yoyamwitsa, amayi omwe ali ndi matenda osokoneza bongo angafunike kusintha zakudya zawo komanso / kapena mtundu.

Mndandanda wazofananira

Tcherani khutu! Mndandandandawu umakhala ndi mawu ofanana a insulin-isophan genetic engineering * (Insulin-isophan *), yokhala ndi mawonekedwe ofanana, motero mutha kusankha nokha, poganizira mawonekedwe ndi kuchuluka kwa mankhwalawa omwe adokotala adawauza. Perekani zokonda kwa opanga ku USA, Japan, Western Europe, komanso makampani odziwika bwino ochokera ku Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Kutulutsa Fomu (mwa kutchuka)	Mtengo, pakani.
Biosulin N
Kuyimitsidwa kwa theka-chikopa int. 100 IU / ml botolo 10 ml 1 pc., Pack. (Pharmstandard - Ufavita, Russia)	576
Kuyimitsidwa kwa nusu-chikopa int. 100 IU / ml cartridge 3 ml 5 ma PC., Pack. (Pharmstandard - Ufavita, Russia)	990
Kuyimitsidwa kwa theka la chikopa. 100 IU / ml cartridge + syringe - cholembera cha Biomatic Pen2 3 ml 5 ma PC., Pack. (Pharmstandard - Ufavita, Russia)	1163
Vozulim-N
Gansulin N
Gensulin N
Umisiri wa Majini a Anthu a Insulin Isophan * (Insulin-isophan *)
Insuman Bazal GT
Solostar, syringe - cholembera 100 IU / ml, 3 ml, ma PC 5. (Sanofi - Aventis, France)	1132
Mabotolo a 100 PIECES / ml, 5 ml, 5 vipande. (Sanofi - Aventis, France)	1394
Insuran NPH
Protamine insulin mwadzidzidzi
Protafan
Protafan HM
Mbale 100 IU / ml, 10 ml	399
Protafan HM Penfill
901
Rinsulin NPH
Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU / ml 10 ml botolo (paketi ya makatoni) (GEROPHARM - Bio LLC (Russia)	420
Kuyimitsidwa kwa makina oyendetsa a 100 IU / ml (makatoni) 3 ml No. 5 (paketi ya makatoni) (GEROFARM - Bio LLC (Russia)	980
Rosinsulin C
Humodar B Mitsinje 100
Humulin NPH
Mbale 100 IU / ml, 10 ml	618
Cartridges 100 IU / ml, 3 ml, ma PC 5.	1137
Humulin ™ NPH

Kugwirizana kwa chinthu insulin-isophan chibadwa chaumunthu chazinthu zina

: glucocorticoids, njira zakulera zam'mlomo, mahomoni a chithokomiro, heparin, thiazide diuretics, antidepressants, danazol, clonidine, sympathomimetics, calcium block blockers, phenytoin, morphine, diazoxide, nikotini.
: Monoamine oxidase zoletsa m'kamwa hypoglycemic mankhwala, angiotensin akatembenuka zoletsa enzyme, kusankha beta-blockers, carbonic anhydrase zoletsa, octreotide, bromocriptine, sulfonamides, tetracyclines, anabolic mankhwala, clofibrate, mebendazole, ketoconazole, pyridoxine, cyclophosphamide, theophylline, mankhwala lifiyamu fenfluramine.
Mothandizidwa ndi salicylates, reserpine, kukonzekera komwe kumakhala ndi ethanol, kufooketsa komanso kuwonjezera zochita za insulin ndizotheka.
Octreotide, lanreotide imatha kuwonjezera kapena kuchepetsa kufunika kwa insulin.
Beta-blockers amatha kuphimba zizindikiro za hypoglycemia ndikuchira pang'onopang'ono pambuyo pa hypoglycemia.
Ndi kuphatikiza kwa mankhwala a insulin ndi thiazolidinedione, ndizotheka kukulitsa kulephera kwa mtima, makamaka kwa odwala omwe ali ndi chiopsezo cha chitukuko chake. Mankhwalawa akaphatikizidwa, amafunika kuwunika odwala kuti azindikire kulephera kwa mtima, kupezeka kwa edema, ndi kunenepa kwambiri. Ngati zizindikiro za kulephera kwa mtima zikuchulukirachulukira kwa odwala, chithandizo cha thiazolidinedione ziyenera kusiyidwa.

Bongo

Ndi mankhwala osokoneza bongo ambiri, hypoglycemia imayamba.
Chithandizo: wodwalayo amatha kuthetsa hypoglycemia yekha, chifukwa chake ndikofunikira kudya zakudya zopatsa mphamvu, kapena shuga mkati, chifukwa chake amalimbikitsidwa kwa odwala omwe ali ndi matenda osokoneza bongo kuti azinyamula shuga, makeke, maswiti, madzi okoma a zipatso. Woopsa hypoglycemia (kuphatikizapo kuchepa kwa chikumbumtima), 40% dextrose solution imayendetsedwa kudzera m'mitsempha, intramuscularly, subcutaneously kapena mtsempha - glucagon. Pambuyo pozindikira, wodwalayo ayenera kudya zakudya zamafuta ambiri kuti aletse kukonzanso kwa hypoglycemia.

Mankhwala amakono amapereka mankhwala ambiri omwe cholinga chake ndi kuchiza matenda ashuga.

Mankhwala ozikidwa pazinthu zatsopano akupangidwa kuti atsimikizire kukhala ndi moyo wabwinobwino kwa odwala ambiri momwe angathere. Mwa othandizira awa, mankhwala monga insulin Isofan ayenera kuganiziridwa.

Zambiri, zikuonetsa kuti mugwiritse ntchito

Mankhwala ndi a gulu la insulin. Ntchito yake yayikulu ndikuthana ndi mawonetsero a shuga mellitus a fomu yodalira insulin.

Amapangidwa ngati mawonekedwe a kuyimitsa jekeseni, chigawo chogwira ntchito chomwe ndi insulin yaumunthu. Kukula kwake kumakhazikitsidwa paukadaulo wa maumboni a DNA. Mankhwala amakhala pafupifupi nthawi yayitali.

Monga mankhwala ambiri m'gululi, Isofan iyenera kugwiritsidwa ntchito pokhapokha ngati dokotala akuwalimbikitsa. Kuwerengera molondola kwa mankhwalawa ndikofunikira kuti musayambitse chiwopsezo cha hypoglycemia. Chifukwa chake, odwala ayenera kutsatira bwino malangizo.

Yambani kugwiritsa ntchito chida ichi pokhapokha ngati pakufunika kutero. Dokotala wopezekapo nthawi zambiri amamuunikira kuti awone ngati mankhwalawo ndi oyenera komanso ngati pakusowa zotsutsana.

Imafotokozedwa ngati:

mtundu 1 shuga
lembani matenda ashuga a 2 shuga (ngati palibe zotsatira zochokera kugwiritsidwa ntchito kwa mankhwala ena omwe ali ndi vuto la hypoglycemic kapena ngati zotsatirazi ndizochepa kwambiri),
kukulitsa kwa matenda ashuga okhudzana ndi mimba (pomwe shuga sangathe kuwongolera ndi chakudya).

Koma ngakhale kukhala ndi matenda oyenera sizitanthauza kuti mankhwalawa ayenera kugwiritsidwa ntchito. Ali ndi zolakwika zingapo, ngakhale ndizochepa.

Kuletsa kokhazikika kumagwira ntchito kokha kwa odwala omwe ali ndi tsankho lililonse pamankhwala awa. M'pofunikanso kusamala posankha mlingo wa odwala omwe ali ndi chizolowezi chowonjezera cha hypoglycemia.

Pali mankhwala angapo omwe amachokera ku chinthu chotchedwa Isofan. M'malo mwake, ndi mankhwala amodzi ndi amodzi. Zomwezo ndizomwe zimapangidwira mu mankhwalawa, zimakhala ndizotsatira zoyipa ndi zotsutsana, kusiyana kumatha kuwonedwa pokhapokha pazomwe zimaphatikizira komanso dzina la malonda. Ndiye kuti, awa ndi mankhwala ofanana.

Zina mwa izo ndi:

Othandizira awa ndi fanizo la Isofan popanga. Ngakhale kufanana kwawo, wodwala yemweyo akhoza kuvuta kugwiritsa ntchito iliyonse ya iwo, ndipo posankha mankhwala ena, zovuta izi zimatha. Nthawi zina muyenera kuyesa mankhwala angapo musanasankhe omwe ali othandiza kwambiri pankhani inayake.

Zizindikiro zogwiritsidwa ntchito

Chizindikiro chachikulu ndicho chithandizo cha matenda amishuga amtundu 1, koma nthawi zina amatha kufotokozedwa pamaso pa matenda a insulin. Chuma chilichonse cha isophane ndi choyenera kuchiza munthu yemwe samatenganso zinthu za hypoglycemic chifukwa chokana kwathunthu kapena pang'ono. Pafupipafupi, mankhwala amagwiritsidwa ntchito mwa amayi apakati omwe ali ndi mtundu wachiwiri wa matenda ashuga.

Kupanga ndi mawonekedwe a kumasulidwa

1 ml yankho lili ndi magawo 100 a yogwira zinthu. Zothandiza - protamine sulfate, madzi osabala a jakisoni, crystalline phenol, sodium dihydrate phosphate, glycerol, metacresol.

Kuyimitsidwa kwa jakisoni, wowonekera. Botolo imodzi ili ndi 3 ml ya chinthu. Phukusi limodzi mumakhala ma cartridge 5 kapena amagulitsidwa mu botolo limodzi pomwe 10 ml ya mankhwalawo.

Kuchiritsa katundu

Isofan insulin ndi nthawi yayitali yogwira chinthu cha hypoglycemic, yomwe idapangidwa pogwiritsa ntchito ukadaulo wa DNA. Pambuyo pa subcutaneous makonzedwe, mahomoni amkati amamangira ku insulin receptor zovuta, zomwe zimapangitsa kuphatikizika kwa mitundu yambiri ya enzyme - hexokinase, pyruvate kinase ndi ena. Chifukwa cha zinthu zomwe zimayambitsidwa kuchokera kunja, kuchuluka kwa glucose kumakula, chifukwa kumatheka kwambiri ndi minofu, ndipo kuchuluka kwa shuga kwa chiwindi kumachepetsedwa kwambiri. Pogwiritsa ntchito pafupipafupi, mankhwalawa amayambitsa machitidwe a lipogenesis, glycogenogeneis ndi proteininogene.

Kutalika kwa kuchitapo kanthu komanso kuchuluka kwa magwiridwe antchito mwa anthu osiyanasiyana kumatengera zinthu zambiri, makamaka makamaka pa kuthamanga kwa zochita za metabolic. Zikutanthauza chiyani - njirayi ndi payekha. Pafupifupi, popeza iyi ndi timadzi tambiri tomwe timayendetsa, zotsatira zoyambira zimayamba mkati mwa ola limodzi ndi theka kuyambira panthawi yoyambira kukonzekera. Kutalika kwa mavutowa ndi maola 24, kuchuluka kwa chidwi kumachitika mkati mwa maola 4-12.

Mankhwalawa amakamizidwa mosiyanasiyana, wowoneka bwino makamaka kudzera mu impso, kuwopsa kwa zotsatirazi kumadalira malo a jekeseni (m'mimba, mkono kapena ntchafu). Mankhwalawa samadutsa chopinga komanso kulowa mkaka wa m'mawere, chifukwa chake amaloledwa kwa amayi apakati komanso ongobadwa kumene.

Zotsatira zoyipa ndi bongo

Hypoglycemia kapena lipodystrophy ndikotheka ngati malamulo a jekeseni ndi mankhwala omwe sanatsatire satsatiridwa. Zocheperako ndizotsatira zoyipa mwanjira ya thupi lawo siligwirizana, kufupika, kutsitsa magazi, hyperhidrosis ndi tachycardia.

Pankhani ya mankhwala osokoneza bongo, zizindikiro zapamwamba za shuga m'magazi zimawonekera: kumva kwamphamvu njala, kufooka, kusazindikira, chizungulire, thukuta, kufunitsitsa kudya maswiti, milandu yayikulu - chikomokere. Zizindikiro zofatsa zimayimitsidwa ndi kudya kwamphamvu thupi, pakati - ndi jakisoni wa dextrose kapena glucose. Nthawi zingapo pamafunika kuyitanidwa kwa madokotala kunyumba.

Geropharm-bio LLC, Russia

Zipangizo zaposachedwa mgawoli:

Pofuna kuti achepetse thupi, atsikana nthawi zambiri amakhala pamakudya atsopano omwe amalonjeza kuti athetsa mapaundi owonjezera mwachangu. Komabe si njira zonse zochepetsera thupi zomwe zimafanana.

Mkazi woyembekezera amakhala wokongola makamaka, ngakhale akukhulupirira zamatsenga kuti atsikana amatenga kukongola kwa mayi wamtsogolo, ndipo anyamata ndi chitsimikizo cha tsogolo.

Ichi ndi matenda endocrine matenda. Chowonetsa chachikulu cha matenda a shuga ndi kukweza m'magazi (shuga). Glucose -.

Zolemba zonse zomwe zimapezeka patsamba lino ndizongodziwa zambiri.

Insulin-isophan: malangizo ogwiritsira ntchito kuyimitsidwa

Chithandizo chogwira ntchito: insulin

genetic engineering wasophane

Wopanga: Novo Nordisk, Denmark

Mkhalidwe wakusiya kwa mankhwala: Mankhwala

Malo osungirako: t mkati madigiri 2-8

Insulin isofan isofan yogwiritsa ntchito chibadwa cha anthu imagwiritsidwa ntchito pochiza matenda omwe amapezeka chifukwa cha kupangika kwa mphamvu ya thupi la munthu ndi insulin. Palibe mankhwala okhala ndi dzina ili pamalonda, popeza uwu ndi mtundu wa chinthu chogwira ntchito, koma pali ma fanizo. Chitsanzo chowoneka bwino cha chinthu chomwe chimagulitsidwa ndi rinsulin.

Chaka chomaliza kusintha

Zomwe zili patsamba lino zinatsimikiziridwa ndi katswiri wazachipatala Vasilieva E.I.

Mwa mankhwala omwe amagwiritsidwa ntchito popanga matenda ashuga, imodzi mwabwino ndi insulin Isofan. Mankhwala ali ndi chibadwa chomanga insulin ya nthawi yayitali.

Zochita za Isofan

Isofan insulin imathandizira kuyamwa kwa glucose ndi minofu komanso imathandizira kaphatikizidwe kabwino ka protein. Glycogenogeneis ndi lipogeneis nawonso amakulitsidwa. Pambuyo pa utsogoleri, kuchuluka kwa shuga kumachepa.

Isofan imagwiritsidwa ntchito ngati matenda a shuga a mtundu woyamba ndi wachiwiri osagwirizana ndi kukana kwa mankhwala a hypoglycemic. Chotsutsana chokha ndi hypersensitivity ku zigawo za mankhwala ndi hypoglycemia.

Insulin imagwira ndi cell membrane receptors ndipo imapanga zovuta za receptor insulin. Pakulowa m'maselo, izi zimayamba kulimbikitsa kapangidwe ka ma enzymes ndi njira zina zowonjezera. Kuyendetsa glucose kumawonjezeka ndipo kuchuluka kwa shuga m'magazi kumachepera.

Isofan amayamba kuchita pafupifupi maola 1.5 atatha kutsata, ndipo zotsatira zake zimakhala bwino pambuyo maola 4. Kutalika kwa mankhwalawa kumatengera mlingo wa munthu ndi kuphatikizidwa ndi insulin, kuyambira maola 11 mpaka 24.

Zovuta ndi zoyipa

Ngakhale njira zabwino zothandizira anthu ena, isulin insulin imatha kuyambitsa zovuta zosiyanasiyana. Izi ndichifukwa cha kuchuluka kwa kagayidwe kazakudya.

Zophwanya zofala kwambiri:

thupi lawo siligwirizana - zikuphatikizapo urticaria, kutsitsa magazi ndi kutentha thupi,
hypoglycemia - yodziwika ndi chisangalalo, nkhawa, kuchuluka kwa njala ndi thukuta lomwe limakulirakulira,
hypoglycemic chikomokere, matenda ashuga,
chikomokere (kuphwanya chikumbumtima),
immunological reaction
kachitidwe ka khungu lakumaloko - kusinthasintha khungu, kuyabwa, kutupa ndi milomo.

Pakumayambiriro kwa mankhwala a insulin, zizindikiro zonse zimatha kukhala zazifupi komanso kuzimiririka patapita nthawi yina atabayidwa.

Ngati mankhwala osokoneza bongo, wodwala amakhala ndi zotsatirazi:

khungu
palpitations
kufooka, mutu,
kukokana
kuwonongeka kwamawonekedwe
hypoglycemic coma,
kumverera kwa mantha
kunjenjemera.

Momwe mungagwiritsire ntchito insulin?

Jakisoni wa isofan insulin uyenera kuchitidwa mphindi 30 kapena 40 asanakadye chakudya kuti mankhwalawa ayambe kugwira ntchito. Insulin imabayidwa subcutaneously 1 nthawi (2 times) patsiku, kuwonjezera apo, nthawi zonse tsamba la jakisoni liyenera kusinthidwa kukhala latsopano. Mlingo wofunikira wa mankhwalawa amawerengedwa ndi adotolo padera kwa wodwala aliyense. Njira yamatendawa komanso kuchuluka kwa shuga mumkodzo amathandizidwanso.

Kwa ana ndi anthu omwe ali ndi chidwi chachikulu ndi mankhwalawa, mlingo uyenera kuchepetsedwa. Mukasinthira ku insulin ina, ndibwino kuti wodwalayo agonekere kuchipatala ndikuwonetsetsa kuchuluka kwa shuga.

Nthawi yomweyo jekeseni isanachitike, insulansi imayang'aniridwa kuti ichitike pang'onopang'ono ndikuyang'ana njira. Contraindication kuti mugwiritse ntchito ndi kuwonongeka kwa vial, kukhalapo kwa mitambo yambiri kapena makhiristo mu yankho. Kutentha kuyenera kukhala kutentha kwa m'chipinda. Muyenera kusintha mlingo wa matenda a chithokomiro komanso matenda opatsirana.

Mankhwala ndi a sing'anga a nthawi yayitali. M'malo mwake, iyi ndi insulin yaumunthu, yomwe idalandiridwa chifukwa cha ukadaulo wa maumboni a DNA.

Mukatenga isofan insulin

Matenda a shuga ndi mtundu II ndi II.
Hypoglycemic mkamwa kukana gawo.
Pochita pamodzi mankhwala, kukana pang'ono mankhwala a gulu lino.
Type II matenda ashuga mwa amayi apakati.
Matenda apakati.

Hypoglycemia Chithandizo

Wodwala amatha kuthana ndi hypoglycemia pakudya chidutswa cha shuga, maswiti kapena zakudya zopatsa thanzi. Chifukwa chake, odwala matenda ashuga ayenera kukhala ndi shuga, ma cookie, maswiti kapena msuzi wa zipatso limodzi nawo.

Masewera a hypoglycemia, wodwalayo akapanda kuzindikira, 40% ya dextrose kapena glucagon amaphatikizidwa kudzera m'mitsempha.

Insulin yomaliza yopanga ma genulin imatha kuperekedwa kudzera m'mitsempha yonse komanso modutsa. Chikumbumtima chikadzabweranso mwa munthu, amafunika kudya zakudya zamafuta ambiri, izi zimalepheretsa kukonzanso kwa hypoglycemia.

Zokhudza zotsatira zamankhwala

Zokhudza ma pharmacological nuances

Kutalika kwa mankhwalawa omwe amaperekedwa ndi insulin makamaka kumatengera kuyamwa. Mlingo woyamwa umadalira mwachindunji magawo ena. Mwachitsanzo:

Pankhaniyi, mawonekedwe owonetsera, omwe amasankha insulin "Isofan", amayikidwa kusinthasintha kwakukulu osati mwa anthu osiyanasiyana, komanso mwa munthu yemweyo. Zambiri zodziwikiratu pambuyo pakupakidwa jekeseni wosonyeza kuti kuwonekera kumachitika pambuyo pa ola limodzi ndi theka, mphamvu yayikulu ikayamba imayamba pakatha maola anayi ndi 12, ndipo nthawi yowonekera imafika maola 24. Izi ndizomwe zitha kunenedwa za insulin Isofan.

Kuchuluka kwa kutsimikiza kumatsimikiziridwa osati kokha ndi mayamwidwe, komanso poyambira mphamvu ya mankhwalawa, komanso malo a jekeseni (gawo la peritoneum, ntchafu, matako), Mlingo (kuchuluka kwa gawo loyambitsidwa), kuchuluka kwa insulini mu mankhwala ndi ena ambiri. Isofan human insulin imagawidwa mu zimakhala zofanana kwenikweni, kuwonjezera apo, ilibe mphamvu yolowera zotchinga, komanso mkaka wa m'mawere. Kusokonezedwa ndi insulinase kumachitika kokha mu chiwindi ndi impso. Insulin yamtunduwu nawonso amathandizidwa ndi impso, izi zimapangitsa 30 mpaka 80%.

Zokhudza mlingo

Kodi mungadziwe bwanji?

Isofan insulin yaumunthu iyenera kuperekedwa kokha pakhungu. Mlingowo umatsimikiziridwa ndi katswiri aliyense payekhapayekha wa wodwala aliyense, yemwe amachitika pamaziko a shuga. Mlingo wamba wa mankhwalawa umasiyana ndi 0,5 mpaka 1 IU pa kg.Zimatengera mkhalidwe wa wodwala matenda ashuga komanso kuchuluka kwa shuga m'magazi.

Isofan human insulin nthawi zambiri imayambitsidwa pansi pa khungu ku ntchafu. Yokha, jakisoni ndiwovomerezeka kuti azichita komanso kukhoma lakumaso kwa chigawo cham'mimba, amodzi mwa matako kapena m'dera la minofu yamapewa. Zizindikiro za kutentha kwa mankhwala omwe adalowetsedwa ziyenera kukhala mogwirizana ndi kutentha kwa chipinda.

Zokhudza kusamala

Mukamagwiritsa ntchito mankhwala aliwonse muyenera kusamala. Chifukwa chake, kugwiritsa ntchito Isofan human insulin tikulimbikitsidwa:

sinthani malo a jakisoni m'dera lomwelo. Izi zikuthandizira kupewa mapangidwe a lipodystrophies amitundu yosiyanasiyana,
Poganizira insulin mankhwala, tikulimbikitsidwa kuyang'anira kuchuluka kwa shuga m'magazi.

Kuphatikiza apo, ziyenera kukumbukiridwa kuti zomwe zimayambitsa hypoglycemia, kuwonjezera pazowonjezera za insulin, zitha kukhala: kuthana ndi mankhwala, kudumpha chakudya, kusanza ndi zovuta zina zam'matumbo, kusintha kwamlingo wochita zolimbitsa thupi kulikonse.

Ikhozanso kukhudzidwa ndi matenda omwe amachepetsa kufunikira kwa mahomoni (kutayika kwa ziwalo monga chiwindi ndi impso, hypo-kugwira ntchito kwa adrenal cortex, gland pituitary, kapena endocrine gland).

Kodi mungapewe bwanji hyperglycemia?

Kugwiritsa ntchito Mlingo woyipa kapena zosokoneza pakubweretsa insulin, makamaka kwa omwe akumana ndi mtundu wa matenda ashuga 1, angayambitse matenda a hyperglycemia. Nthawi zambiri, mawonetseredwe oyamba a hyperglycemia amayamba kuwonjezeka, maola ambiri kapenanso masiku.

Amaphatikizapo kupanga ludzu, kukodza pokoka komanso zizindikiro zina. Komanso, kuti mukhale osamala kwambiri, ndikofunikira kukumbukira ma contraindication, omwe amawira mpaka kuwonjezeka kwa kumverera kwakukulu ndi hypoglycemia.

Chifukwa chake, kugwiritsa ntchito insulin yamtunduwu ngati munthu wokhala ndi nthawi yayitali yotchedwa Isofan kuyenera kuchitika motsatira malingaliro omwe aperekedwa. Ichi ndiye chinsinsi chofunikira kwambiri ndi matenda monga matenda a shuga.

Rinsulin PNH

Geropharm-bio LLC, Russia

Mtengo wapakati ku Russia ndi ma ruble a 1000 paphukusi lililonse.

Rinosulin ndi analogue yathunthu ndipo imakhala ndi sing'anga wapakati. Mtundu wa mankhwalawa ndi wabwino chifukwa sufunikira kukonzekera pafupipafupi.

Osati otsika mtengo
Zotsatira zoyipa ndizotheka.

Isofan Insulin ndi timadzi tating'onoting'ono topangidwa ndi anthu

Pakukonzanso mankhwala a shuga, onse madigiri 1 ndi 2, timadzi timene timatulutsidwa m'thupi timagwira gawo lofunikira pa nthawi. Mankhwala atsopano a Insulin Isofan azithandiza odwala matenda ashuga kukhala bwino. Chithandizo cha matenda ashuga omwe ali ndi insulin ali ndi cholowa m'malo.

Cholinga chakulowerera kwachipatala koteroko ndikupanga kutayika kapena kuchuluka kwa chakudya m'thupi momwe zimayambira pokhazikitsidwa ndi mahomoni apadera. Hormone iyi imakhudza thupi chimodzimodzi ndi insulin yachilengedwe yomwe kapamba amapanga. Chithandizo chake chimakhala chosakwanira kapena chokwanira.

Pakati pa mankhwala omwe amagwiritsidwa ntchito mochizira matenda a shuga mellitus 2 ndi 1 degree, insulin Isofan yatsimikizira bwino. Zimaphatikizanso insulin yaumisiri wa anthu, yomwe imakhala ndi nthawi yayitali kuchitapo kanthu.

Mankhwalawa, mahomoni awa, ofunikira kwambiri kwa moyo wathunthu wa munthu yemwe ali ndi mavuto a shuga mu

magazi amapangidwa m'njira zosiyanasiyana:

Kuwongolera pansi pa khungu,
Kuti muikemo mtsempha,
Kwa makonzedwe a mu mnofu.

Kusankha kumeneku kumapangitsa kuti munthu wodwala matenda ashuga osiyanasiyana azilamulira kuchuluka kwa shuga m'magazi mwa njira iliyonse yomwe ingayambitse magazi, kusintha ndikofunikira.

Isofan insulini - zikuonetsa:

Kukanani ndi mankhwala ochepetsa shuga omwe muyenera kumwa mu mawonekedwe a mapiritsi monga gawo la chithandizo chokwanira,
Matenda a shuga a 2 ndi 1 degree, amadalira insulin,
Matenda a shuga, ngati palibe zotsatira kuchokera kuzakudya,
Matenda a mtundu wokhazikika.

Zimagwira bwanji?

Isofan insulin umangidwe wa chibadwa cha anthu umakhudza thupi, kupereka mphamvu ya hypoglycemic. Mankhwalawa amakumana ndi ma cytoplasmic receptors a cell membrane. Izi zimapanga zovuta za insulin receptor. Ntchito yake ndikupanga kagayidwe kamphamvu kamene kamachitika mkati mwa maselo iwowo, ndikuthandizanso pakupanga kwakukulu kwa michere yonse yomwe ilipo.

Kuchepetsa kuchuluka kwa shuga m'magazi kumachitika ndikuwonjezera mayendedwe ake mkati mwa cell, komanso mwa kuchepetsa kuchuluka kwa shuga, pothandizira pakuyamwa. Ubwino wina wa insulin ya anthu ndi kaphatikizidwe wa mapuloteni, kutsegula kwa lithogenesis, glycogenogeneis.

Nthawi yayitali yomwe mankhwalawa amagwira mwachindunji molingana ndi kuchuluka kwa momwe mankhwalawa amathandizira kulowa m'magazi, ndipo mayamwidwe ake amatengera njira yoyendetsera ndi mankhwalawa. Chifukwa chake, zotsatira za mankhwalawa ndizosiyana mwa odwala osiyanasiyana.

Pachikhalidwe, pambuyo pa jekeseni, mphamvu ya mankhwalawa imayamba pambuyo pa maola 1.5. Chiwopsezo cha kugwira ntchito zimachitika pang'onopang'ono maola 4 mutatha kuperekera mankhwala. Kutalika kwa kuchitapo kanthu ndi maola 24.

Kuchuluka kwa Isofan kumadalira izi:

Tsamba la jekeseni (matako, pamimba, ntchafu),
Yogwira pophika
Mlingo.

Mankhwalawa amachotseredwa ndi impso.

Momwe mungagwiritsire ntchito: Zizindikiro zakugwiritsa ntchito

Malinga ndi malangizo ogwiritsidwira ntchito a Isofan, amayenera kuperekedwa kawiri patsiku: m'mawa ndi madzulo asanadye (adzaphwanyidwa asanadye). Tsamba la jakisoni liyenera kusinthidwa tsiku lililonse, syringe yomwe imagwiritsidwa ntchito iyenera kusungidwa mwachizolowezi, kutentha koyenera, ndipo chatsopanochi chizikhala chonyamula, mufiriji. Nthawi zambiri, mankhwalawa amalowetsedwa m'matumbo, koma osagwirizana konse, chifukwa ndi insulin.

Mlingo wa mankhwalawa amawerengedwa aliyense payekha kwa aliyense amene ali ndi matenda a shuga, pokambirana ndi adokotala. Kutengera kuchuluka kwa shuga mu plasma ndi kutsimikiza kwa shuga. Mlingo wambiri watsiku ndi tsiku, mosiyanasiyana umasiyana pakati pa 8-24 IU.

Ngati hypersensitivity kwa insulin, ndikofunikira kutenga zosaposa 8 IU patsiku, ngati mahomoni samadziwika bwino, mlingo ungathe kuwonjezeka mpaka 24 kapena kuposa IU masana. Ngati mlingo wa tsiku ndi tsiku wa mankhwalawa uzidutsa 0 6 IU pa kilogalamu ya thupi la wodwalayo, ndiye kuti jakisoni 2 amapangidwa nthawi imodzi m'malo osiyanasiyana.

Urticaria,
Hypotension
Kutentha kwamphamvu
Zovuta
Kupuma pang'ono
Hypoglycemia (mantha, kusowa tulo, kutulutsa nkhope, kupsinjika, kukwiya, kuyamwa njala, miyendo ndi kunjenjemera),
Matenda ashuga Acidosis
Hyperglycemia,
Zowonongeka
Kutupa ndi kuyabwa pamalowa jakisoni.

Mankhwala osokoneza bongo a mankhwala ambiri amakhala ndi hypoglycemia ndi chikomokere. Kuchulukitsa kwa mankhwalawa sikungasokonezeke ngati mumadya zakudya zopatsa thanzi (chokoleti, maswiti, makeke, tiyi wokoma).

Pofuna kutaya chikumbumtima, yankho la Dextrose kapena Glucagon liyenera kuperekedwa kwa wodwala. Chikumbumtima chikadzabweranso, wodwala amayenera kupatsidwa chakudya chambiri chamagulu omoto. Izi zitha kupewa kuti glycemic coma ndi hypoglycemic zisabwerenso.

Isofan insulin: ndingagwiritse ntchito ndi mankhwala ena

Kuchulukitsa kwa hypoglycemic (kusintha shuga kwa magazi) matenda a Isofan ndi:

Sulfonamides,
Chloroquinine
ACE inhibitors / MAO / carbonic anhydrase,
Ethanoli
Mebendazole,
Njira zomwe zili m'gulululi ndi anabolic steroids,
Fenfluramine
Mankhwala a Tetracycline
Clofibrate
Malangizo a gulu la theofylline.

Mphamvu ya hypoglycemic (kubweretsa kuchuluka kwa shuga m'magazi kuti ikhale yofananira) imachepetsedwa chifukwa cha matenda a Isofan omwe ali ndi mankhwalawa:

Kuchuluka kwa shuga m'magazi kumachepa chifukwa cha mtundu wa insulin Isofan wokhala ndi thiazide ndi loop diuretics, wokhala ndi BMCC, komanso mahomoni a chithokomiro, sympathomimetics, Klondin, Danazole, sulfinpyrazone. Morphine, chamba, mowa ndi chikonga zimachetsanso shuga m'magazi. Odwala omwe ali ndi matenda ashuga sayenera kumwa kapena kusuta.

Kuphatikiza pakuphatikiza kwamankhwala osayenera ndi Isofan, zinthu monga zomwe zimayambitsa hypoglycemia komanso:

Mukasinthira ku mankhwala ena omwe amakhala ndi shuga wamba,
Kusanza kwa matenda ashuga
Matenda a shuga
Kuchuluka kwathupi katundu
Matenda omwe amachepetsa kufunika kwa insulin (pituitary, hypothyroidism, kulephera kwa chiwindi, kulephera kwaimpso),
Wodwala sanadye pa nthawi.
Kusintha kwa tsamba la jakisoni.

Mlingo wosalondola kapena nthawi yayitali pakati pa jakisoni ingayambitse matenda a hyperglycemia (makamaka munthawi ya matenda a shuga 1). Ngati mankhwalawa sasinthika pakapita nthawi, wodwalayo amatha kugwa ketoacidotic.

Wodwala yemwe amagwiritsa ntchito mankhwalawa ndi okalamba kuposa zaka makumi asanu ndi limodzi, ndipo makamaka yemwe ali ndi vuto la chithokomiro, impso, chiwindi, ndikofunikira kufunsa dokotala wothandizidwa ndi insulin Isofan. Njira zomwezi ziyenera kumwedwa ngati wodwala akudwala hypopituitarism kapena matenda a Addison.

Momwe mungasinthire: malangizo apadera

Musanamwe mankhwalawo mu syringe, onani ngati yankho lake ndi mitambo. Ziyenera kukhala zowonekera. Ngati ma ntchofu, matupi akunja aoneka, yankho lafika pamtambo, mpweya watuluka, mankhwalawo sangathe kugwiritsidwa ntchito.

Kutentha kwa mankhwala operekedwa kuyenera kukhala kutentha kwa chipinda. Ngati pakadali pano muli ndi chimfine kapena zambiri ndi matenda ena opatsirana, muyenera kufunsa dokotala za mankhwalawo. Mukalowetsa mankhwalawa, izi zikuyenera kuchitika moyang'aniridwa ndi dokotala, ndikwanzeru kupita kuchipatala.

Mimba, mkaka wa m`mawere ndi insulin Isofan

Amayi oyembekezera omwe ali ndi matenda ashuga amatha kutenga Isofan insulin, sangafike kwa fetus kudzera mu placenta. Mutha kugwiritsa ntchito ndi kuyamwitsa amayi, okakamizidwa kuti mukhale ndi matenda. Ndikofunikira kudziwa kuti panthawi yomwe muli ndi pakati pa trimester yoyamba, kufunika kwa insulin kumachepa, ndipo wachiwiri ndi wachitatu trimester imawonjezeka.

Kuyimitsidwa mosalephera kwa insulin ya anthu a nthawi yayitali.

Zizindikiro Isofan-Insulin World Cup

Matenda a shuga omwe amadalira a insulin: ma allergies a mitundu ina ya insulin, yolimbitsa insulin mankhwala (majekiseni osafunikira, ma syringes amtundu wa PEN, ndi zina zotere), mwa odwala omwe ali ndi vuto lalikulu la mtima wamatenda a shuga, pazida zokhala ndi cholinga chapadera (ma finya kapamba, etc.) , osadalira shuga omwe amadalira insulin (kuphatikiza mankhwalawa ndi mankhwala amkamwa a hypoglycemic, chithandizo chochepa cha insulin).

Mafotokozedwe a magulu a nosological

Siyani ndemanga yanu

Chidziwitso Chaposachedwa Chidziwitso Chaposachedwa, ‰

Chithandizo choyamba
Ogulitsa pa intaneti
Za kampani
Zambiri

Wofalitsa:
Imelo:
Adilesi: Russia, Moscow, st. 5 Thunthu, d.12.

Mukamagwiritsa ntchito zidziwitso zofalitsidwa pamasamba a webusayiti ya www.rlsnet.ru, kulumikizana ndi gwero lachidziwitso ndikofunikira.

Maumwini onse ndi otetezedwa.

Kugwiritsa ntchito malonda pazinthu sikuloledwa.

Uthengawu umapangidwira akatswiri azaumoyo.

Humulin NPH

Eli Lilly East, Switzerland

Mtengo wapakati mu Russia ndi 17 ruble.

Humulin NPH ndi analog ya kuchuluka kwapakatikati.

Isofan Insulin ndi timadzi tating'onoting'ono topangidwa ndi anthu

Mankhwalawa, mahomoni awa, ofunikira kwambiri kwa moyo wathunthu wa munthu yemwe ali ndi mavuto a shuga mu

magazi amapangidwa m'njira zosiyanasiyana:

Kuwongolera pansi pa khungu,
Kuti muikemo mtsempha,
Kwa makonzedwe a mu mnofu.

Kusankha kumeneku kumapangitsa kuti munthu wodwala matenda ashuga osiyanasiyana azilamulira kuchuluka kwa shuga m'magazi mwa njira iliyonse yomwe ingayambitse magazi, kusintha ndikofunikira.

Isofan insulini - zikuonetsa:

Kukanani ndi mankhwala ochepetsa shuga omwe muyenera kumwa mu mawonekedwe a mapiritsi monga gawo la chithandizo chokwanira,
Matenda a shuga a 2 ndi 1 degree, amadalira insulin,
Matenda a shuga, ngati palibe zotsatira kuchokera kuzakudya,
Matenda a mtundu wokhazikika.

Isofan: analogu ndi mayina ena

Mayina amalonda a Isofan insulin akhoza kukhala motere:

Zimagwira bwanji?

Pachikhalidwe, pambuyo pa jekeseni, mphamvu ya mankhwalawa imayamba pambuyo pa maola 1.5. Chiwopsezo cha kugwira ntchito zimachitika pang'onopang'ono maola 4 mutatha kuperekera mankhwala. Kutalika kwa kuchitapo kanthu ndi maola 24.

Kuchuluka kwa Isofan kumadalira izi:

Tsamba la jekeseni (matako, pamimba, ntchafu),
Yogwira pophika
Mlingo.

Mankhwalawa amachotseredwa ndi impso.

Momwe mungagwiritsire ntchito: Zizindikiro zakugwiritsa ntchito

Ngati hypersensitivity kwa insulin, ndikofunikira kutenga zosaposa 8 IU patsiku, ngati mahomoni samadziwika bwino, mlingo ungathe kuwonjezeka mpaka 24 kapena kuposa IU masana.Ngati mlingo wa tsiku ndi tsiku wa mankhwalawa uzidutsa 0 6 IU pa kilogalamu ya thupi la wodwalayo, ndiye kuti jakisoni 2 amapangidwa nthawi imodzi m'malo osiyanasiyana.

Urticaria,
Hypotension
Kutentha kwamphamvu
Zovuta
Kupuma pang'ono
Hypoglycemia (mantha, kusowa tulo, kutulutsa nkhope, kupsinjika, kukwiya, kuyamwa njala, miyendo ndi kunjenjemera),
Matenda ashuga Acidosis
Hyperglycemia,
Zowonongeka
Kutupa ndi kuyabwa pamalowa jakisoni.

Isofan insulin: ndingagwiritse ntchito ndi mankhwala ena

Kuchulukitsa kwa hypoglycemic (kusintha shuga kwa magazi) matenda a Isofan ndi:

Sulfonamides,
Chloroquinine
ACE inhibitors / MAO / carbonic anhydrase,
Ethanoli
Mebendazole,
Njira zomwe zili m'gulululi ndi anabolic steroids,
Fenfluramine
Mankhwala a Tetracycline
Clofibrate
Malangizo a gulu la theofylline.

Mphamvu ya hypoglycemic (kubweretsa kuchuluka kwa shuga m'magazi kuti ikhale yofananira) imachepetsedwa chifukwa cha matenda a Isofan omwe ali ndi mankhwalawa:

Kuphatikiza pakuphatikiza kwamankhwala osayenera ndi Isofan, zinthu monga zomwe zimayambitsa hypoglycemia komanso:

Mukasinthira ku mankhwala ena omwe amakhala ndi shuga wamba,
Kusanza kwa matenda ashuga
Matenda a shuga
Kuchuluka kwathupi katundu
Matenda omwe amachepetsa kufunika kwa insulin (pituitary, hypothyroidism, kulephera kwa chiwindi, kulephera kwaimpso),
Wodwala sanadye pa nthawi.
Kusintha kwa tsamba la jakisoni.

Isofan insulin: mtengo

Mtengo wa Isofan insulin umasiyanasiyana kuchokera ku 500 mpaka 1200 rubles pa phukusi lililonse, lomwe limaphatikizapo ma ampoules 10, kutengera dziko lopanga ndi kipimo.

Momwe mungasinthire: malangizo apadera

Mimba, mkaka wa m`mawere ndi insulin Isofan

Amayi oyembekezera omwe ali ndi matenda ashuga amatha kutenga Isofan insulin, sangafike kwa fetus kudzera mu placenta. Mutha kugwiritsa ntchito ndi kuyamwitsa amayi, okakamizidwa kuti mukhale ndi matenda.Ndikofunikira kudziwa kuti panthawi yomwe muli ndi pakati pa trimester yoyamba, kufunika kwa insulin kumachepa, ndipo wachiwiri ndi wachitatu trimester imawonjezeka.

Kuyimitsidwa mosalephera kwa insulin ya anthu a nthawi yayitali.

Zotsatira za pharmacological

Imayendetsa phosphatidylinositol dongosolo, imasinthira mayendedwe am'magazi ndi ma ion, imasintha polarization wa membrane (imawonjezera kulowa kwa potaziyamu mu cell), imayendetsa hexokinase ndi glycogen synthetase, ndikulimbikitsa kuyamwa kwa amino acid ndi maselo.

Clinical Pharmacology

Zotsatira akuyamba 1-2 patatha makonzedwe, ukufika pazitali ndi maola 6-12 ndipo kumatha maola 18- 24.

Zizindikiro Isofan-Insulin World Cup

Contraindication

Hypoglycemic zinthu, chikomokere.

Zotsatira zoyipa

Hypoglycemia.

Mlingo ndi makonzedwe

S / c, v / m, zomwe zili mu vial zimagwedezeka bwino musanazigwiritse ntchito ndikuvulaza nthawi yomweyo mutadzaza syringe. Mlingo umatsimikiziridwa payekhapayekha.

Njira zopewera kupewa ngozi

Osalowanso pamalo omwewo. Ndi makonzedwe a munthawi yomweyo komanso yankho la insulin yaumunthu, Intral XM imayamba kusungidwa mu syringe. Gwiritsani ntchito mosamala vuto la kulephera kwa impso, motsutsana ndi kumbuyo kwa matenda, ndi hypopituitarism, kutenga pakati, mwa anthu opitilira zaka 65.

Zosungidwa za mankhwala Isofan-Insulin FM

Pewani kufikira ana.

Isofan-Insulin World Cup

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa phukusi.

Mafotokozedwe a magulu a nosological

Siyani ndemanga yanu

Chidziwitso Chaposachedwa Chidziwitso Chaposachedwa, ‰

Chithandizo choyamba
Ogulitsa pa intaneti
Za kampani
Zambiri

Wofalitsa:
Imelo:
Adilesi: Russia, Moscow, st. 5 Thunthu, d.12.

Mukamagwiritsa ntchito zidziwitso zofalitsidwa pamasamba a webusayiti ya www.rlsnet.ru, kulumikizana ndi gwero lachidziwitso ndikofunikira.

Maumwini onse ndi otetezedwa.

Kugwiritsa ntchito malonda pazinthu sikuloledwa.

Uthengawu umapangidwira akatswiri azaumoyo.

Insulin Isofan Wothandiza Wodwala Matenda A shuga

Insulin imathandizira kuchepa kwa shuga m'magazi. Koma nthawi yomweyo, mankhwala onse ali ndi contraindication, ndipo musayiwale izi. Mukamamwa mankhwalawa, muyenera kukumbukira mlingo wake.

Kutulutsa mafomu, mtengo wake

Mankhwala amapezeka poyimitsa. Cholinga chake ndi kayendetsedwe ka subcutaneous. Mankhwalawa amakhala ndi nthawi yokwanira kuchitapo kanthu. Nthawi yomweyo, amachepetsa kuchuluka kwa glucose m'magazi ndikuwathandizira kuti azitha kulowa mu minofu. Imathandizira njira ya kaphatikizidwe wa mapuloteni, glycogenogeneis ndi lipogeneis.

kuchuluka kwa kuyamwa
Mlingo wa makonzedwe
tsamba la jakisoni ndi ena ambiri ena

Kuchuluka kwa insulini m'magazi, molondola kwambiri m'madzi a m'magazi, amasonkhana kuyambira maola 2 mpaka 18 kuyambira nthawi ya jakisoni. Pankhaniyi, insulin sichigwirizana ndi mapuloteni.Kugawa kwake m'thupi lathu lonse sikofanana. Mankhwalawa samadutsa mkaka wa m'mawere, komanso kudzera pazotchinga kuchokera ku placenta.

Zimangotenga mphindi zochepa kuti muchotse magaziwo, koma kuti achotse thupi, amachotsedwa maola 5 mpaka 10. Impso zimachotsa mpaka 80%. Pochita kafukufuku, palibe chowopsa chomwe chidapezeka m'thupi. Malangizo ogwiritsira ntchito mankhwalawa ndi ochuluka kwambiri. Imafotokoza bwino magawo onse a pulogalamuyi.

Zizindikiro ndi contraindication

Mukanyamula mwana, musanyalanyaze kupita ku madokotala. Potere, kuyang'anira kuchuluka kwa glucose ndikofunikira. Panthawi yakukonzekera kutenga pakati, muyenera kutsatira malangizo onse omwewa.

Kukhazikitsa kwa mankhwala kumatheka pokhapokha. Palibe chifukwa muyenera kuperekera mankhwalawa.

Mu matenda a impso ndi chiwindi, kufunika kwa insulin kumachepetsa kwambiri. Ntchito yolakwika ya chithokomiro ingayambitse zotsatira zomwezo.

Ulendo wokhudzana ndikusintha nyengo uyenera kuvomerezedwa ndi dokotala. Cholinga cha izi ndizosavuta. Mukamasintha nthawi, nthawi yakudya komanso mankhwala asintha.

Ngakhale mukumwa mankhwalawo, makamaka poyambira, akhoza kuchepa mphamvu yakuyendetsa galimoto ndi magalimoto ena.

Protafan NM,
Humulin,
Actrafan NM.

Mwa kuwonekera batani "Tumizani", mumavomereza mfundo zachinsinsi zachinsinsi ndikupereka chilolezo chanu pakugwiritsa ntchito deta yanu pazokha komanso pazolinga zomwe zafotokozedwazo.

Insulin-isophan: malangizo ogwiritsira ntchito kuyimitsidwa

Chithandizo chogwira ntchito: insulin

genetic engineering wasophane

Wopanga: Novo Nordisk, Denmark

Mkhalidwe wakusiya kwa mankhwala: Mankhwala

Malo osungirako: t mkati madigiri 2-8

Zizindikiro zogwiritsidwa ntchito

Kupanga ndi mawonekedwe a kumasulidwa

1 ml yankho lili ndi magawo 100 a yogwira zinthu. Zothandiza - protamine sulfate, madzi osabala a jakisoni, crystalline phenol, sodium dihydrate phosphate, glycerol, metacresol.

Kuyimitsidwa kwa jakisoni, wowonekera. Botolo imodzi ili ndi 3 ml ya chinthu. Phukusi limodzi mumakhala ma cartridge 5 kapena amagulitsidwa mu botolo limodzi pomwe 10 ml ya mankhwalawo.

Kuchiritsa katundu

Njira yogwiritsira ntchito

Mtengo wapakati wa mankhwala ku Russia ndi ma ruble 1075 pa paketi iliyonse.

Kubaya jakisoni, kamodzi patsiku, m'malo osiyanasiyana. Pafupipafupi jakisoni malo amodzi sayenera kupitirira nthawi 1 pamwezi, chifukwa chake malo oyendetsera mankhwalawa amasinthidwa nthawi iliyonse. Asanagwiritse ntchito mwachindunji, ma ampoules adagulungika m'manja. Malangizo oyendetsera jakisoni - chithandizo chosawoneka bwino, singano amawayikidwa pang'onopang'ono mpaka madigiri 45 m'mphepete mwa njira, kenako malowo ndi ophera tizilombo toyambitsa matenda. Mlingo amasankhidwa ndi dokotala payekhapayekha.

Pa nthawi yoyembekezera komanso yoyamwitsa

Mankhwala amavomerezedwa kuti azigwiritsidwa ntchito nthawi izi.

Contraindication ndi Kusamala

Izi zimaphatikizira: kusalolera ku chinthu china chake chogwira ntchito komanso shuga pang'ono panthawi inayake.

Kuchita mankhwala osokoneza bongo

Kuchepetsa mphamvu ya mankhwalawa: systemic glucocorticoids, kulera kwapakamwa, estradiol ndi progesterone, anabolic steroids, diuretics, antidepressants, mahomoni a chithokomiro.

Kuchulukitsa ntchito: mowa, salicylates, sulfonamides ndi beta-blockers, Mao inhibitors.

Zotsatira zoyipa ndi bongo

Rinsulin PNH

Geropharm-bio LLC, Russia

Mtengo wapakati ku Russia ndi ma ruble a 1000 paphukusi lililonse.

Rinosulin ndi analogue yathunthu ndipo imakhala ndi sing'anga wapakati. Mtundu wa mankhwalawa ndi wabwino chifukwa sufunikira kukonzekera pafupipafupi.

Osati otsika mtengo
Zotsatira zoyipa ndizotheka.

Humulin NPH

Eli Lilly East, Switzerland

Mtengo wapakati mu Russia ndi 17 ruble.

Humulin NPH ndi analog ya kuchuluka kwapakatikati.

The zikuchokera mankhwala

Insulin yomwe imagwiritsidwa ntchito mu shuga imagawidwa m'magulu akulu akulu kutengera nthawi yomwe akuchitapo kanthu. Kuti mutsanzire kwathunthu katemera wanu wa insulin, mumafunikira mitundu iwiri ya mahomoni: yayitali (kapena yapakatikati) ndi yochepa (kapena ultrashort) -. Isofan imatchulidwa ngati insulin yapakati. Pogwiritsa ntchito magawo awiri patsiku, imatha kupereka kuchuluka kwa mahomoni m'magazi, komwe kumachepetsa glucose omwe amalowa m'magazi kuchokera pachiwindi kuzungulira nthawi.

Isofan insulini ilipo 2:

Insulin . M'mbuyomu, mahomoni a nkhumba ndi bovine anali ogwiritsidwa ntchito, tsopano ndi maumboni amtundu wa anthu omwe amagwiritsidwa ntchito, omwe ali ofanana ndi mahomoni opangidwa ndi kapamba amunthu. Amapangidwa pogwiritsa ntchito mabakiteriya osinthika, mankhwalawa amakhala ndi kuyeretsa kambiri, amadziwika mosavuta ndi thupi ndipo sakonda kuyambitsa ziwengo kusiyana ndi omwe adalipo kale.
Protamine - mapuloteni omwe amagwiritsidwa ntchito ngati ntchito yowonjezera insulin. Tithokoze iye, nthawi yoperekera mahomoni kuchokera ku minyewa yolumikizira minyewa imawonjezeka kuchoka pa maola 6 mpaka 12. Mu insulin, mahomoni a Isofan ndi protamine ali osakanikirana ndi kuchuluka kwa isophane, ndiye kuti, panjirazi palibe zochulukirapo pazinthu zilizonse. Mwa dzina la yemwe adamupanga, wasayansi waku Danish Hagedorn, insulin Isofan nthawi zambiri amatchulidwa m'mabuku azachipatala kuti ndi protamine Hagedorn, kapena NPH-insulin.

Kotero kuti protamine yokhala ndi insulin imatha kupanga makhiristo, zinc imawonjezeredwa ku yankho. Phenol ndi m-cresol amapezeka pokonzekera ngati zosungirako; kuti mupeze yankho losagwirizana ndi acidity, asidi wofooka kapena woyambira amagwiritsidwa ntchito. Zofanizira zopimira zosiyanasiyana, kapangidwe kazinthu zothandizira ndizosiyana, mndandanda wathunthu umaperekedwa mu malangizo ogwiritsa ntchito.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

Matenda a shuga ndi omwe amayambitsa pafupifupi 80% yonse yamikwingwirima ndi kuduladula. Anthu 7 mwa anthu 10 amafa chifukwa cha mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chomaliza chomaliza ndi chimodzimodzi - shuga wamwazi.

Shuga akhoza ndipo amayenera kugwetsedwa, apo ayi. Koma izi sizichiritsa matendawa, koma zimangothandiza kulimbana ndi kufufuza, osati zomwe zimayambitsa matendawa.

Mankhwala okhawo omwe amalimbikitsidwa mwalamulo kwa odwala matenda ashuga komanso ogwiritsidwa ntchito ndi endocrinologists pantchito yawo ndi Ji Dao Diabetes Adhesive.

Kugwiritsa ntchito bwino kwa mankhwalawa, kuwerengera malinga ndi njira yokhazikika (kuchuluka kwa odwala omwe achiwonjezere kuchuluka kwa odwala omwe ali pagulu la anthu 100 omwe adachitiridwa chithandizo):

Matenda a shuga - 95%
Kuthetsa kwa mitsempha thrombosis - 70%
Kuthetsa kwa kugunda kwamtima kwamphamvu - 90%
Kuthana ndi kuthamanga kwa magazi - 92%
Kulimbitsa tsiku, kukonza kugona usiku - 97%

Opanga Ji Dao si bungwe lazamalonda ndipo amalipiridwa ndi boma. Chifukwa chake, tsopano wokhala aliyense ali ndi mwayi wopeza mankhwalawo kuchotsera 50%.

Zisonyezero zakudikirira

Chifukwa choika basulin yokumba insulin:

Mtundu umodzi wa matenda ashuga. Njira yowonjezereka ya insulin mankhwala imagwiritsidwa ntchito, ndiye kuti, ISofan ndipo imagwiritsidwa ntchito.
Mitundu ina.
Lembani 2, ngati mapiritsi a hypoglycemic adatsatiridwa kapena samapereka chiwongolero chokwanira cha matenda ashuga. Monga lamulo, mankhwala a insulin amayamba ndi Isofan. Kufunika kwa mahomoni ofupikira kumawonekera pambuyo pake.
Lembani 2 pakubala.
Monga m'malo mwa mapiritsi, ngati mitundu yachiwiri ya matenda a shuga yapezeka. Pambuyo pakuchepetsa shuga, wodwalayo amatha kusamutsidwanso kukonzekera kukamwa.
Matenda a gestational, ngati sangachepetse shuga kukhala abwinobwino.

Zizindikiro

Isofan Insulin ndiye insulin wotchuka kwambiri padziko lapansi. Mankhwala amakono ambiri ndiokwera mtengo kwambiri ndipo ayamba kugulitsa msika. Mayina amalonda otsatirawa a Isofan amalembetsedwa ku Russian Federation:

Dzinalo	Mtengo, pakani.	Katemera, njira yoyendetsera		Wopanga
Dzinalo	Mtengo, pakani.	Mabotolo, syringe wa insulin	Makatoni, Syringe Pens	Wopanga
Biosulin N	kuchokera 506	+	+	Mankhwala
kuchokera 400	+	+	Heropharm
Rosinsulin C	kuyambira 1080	+	+	Chomera cha Medsintez
Protamine insulin mwadzidzidzi	kuyambira 492	+	—	ZOSAKHALA
Gensulin N	—	+	+	MFPDK BIOTEK
Insuran NPH	—	+	—	IBCh RAS
kuchokera pa 600	+	+	Eli Lilly
kuyambira 1100	+	+	Sanofi
kuyambira 370	+	+	Novo Nordisk
Vozulim-N	—	+	+	Wokhard Limited

Mankhwala onse omwe ali pamwambapa ndi ma analogu. Amakhala ndi nkhawa yofananira ndipo ali pafupi ndi mphamvu, chifukwa chake, ndi matenda ashuga, ndizotheka kusintha kuchokera ku mankhwala amtundu wina kupita kwina popanda kusintha kwa mlingo.

Kodi chinthucho chimapangidwa kuti?

Malangizo ogwiritsira ntchito akuwonetsa kuti zomwe zikuwonetsa kugwiritsa ntchito Insulin-isophan ndi:

mawonekedwe a shuga a insulin
shuga yosadalira insulin,
osagwirizana ndi zomwe amapezeka piritsi yotsitsa shuga,
kupezeka kwamatenda oyamba (omwe amalumikizika mwamwayi, koma ochulukitsa matendawa).
shuga ya amayi apakati.

Mimba komanso kuyamwa

Zomwe zimagwiritsidwa ntchito ndi mankhwalawa sizilowa mkaka wa m'mawere komanso kudzera mu zotchinga, chifukwa chake, insulin-isofan imatha kupatsidwa kwa azimayi panthawi yakumwa ndi yoyamwitsa. Ndikofunika kuwerengera molondola kuchuluka kwa mankhwala omwe waperekedwa chifukwa chawonjezereka kapena kuchepa kwa shuga m'magazi a amayi mukamagwiritsa ntchito mlingo woyenera umawonekera kwa mwana wosabadwayo.

Kuyanjana kwa mankhwala

Pali mankhwala omwe amatha kupititsa patsogolo zotsatira za hypoglycemic za Insulin-isophan, koma pali zina zomwe, m'malo mwake, zimafooketsa, zomwe zimapangitsa kuti magazi a wodwalayo awonjezeke.

Gulu loyamba la mankhwalawa limaphatikizapo:

mapiritsi ochepetsa shuga,
ACE zoletsa
sulfonamides,
maantibayotiki ena
anabolic steroids
mankhwala antifungal
Theofylline
Kukonzekera kwa lithiamu
Clofibrate.

Oimira gulu la tetracycline amatha kupititsa patsogolo zotsatira za insulin

Gulu lachiwiri limaphatikizapo:

mahomoni a adrenal cortex,
Ma COC
mahomoni a chithokomiro,
heparin
okodzetsa
antidepressants
amphanomachul.

Malamulo oyambira

Mlingo wa Isofan umasankhidwa choyambirira, kufupikitsa insulin. Ndi payekha payekhapayekha wodwala matenda ashuga. Pafupifupi kufunika kwa mahomoni kusowa kwa munthu ndi zigawo za 0.3-1 pa kilogalamu imodzi yakulemera, Isofan imakhala ndi 1/3 mpaka 1/2 ya kufunika. Insulin yocheperako imafunikira mtundu wachiwiri wa matenda ashuga, ochulukirapo - kwa odwala omwe ali ndi kunenepa kwambiri komanso kukana insulin. Zolemba muzakudya sizikhudza kwenikweni mtundu wa Isofan, popeza insulin yochepa imathandizira kulipirira prandial glycemia.

Momwe mungasinthire Isofan:

Malangizowo akuwongolera kuperekera mankhwalawo pang'onopang'ono. Kuti yankho lisalowe mu minofu, muyenera kusankha molondola kutalika kwa singano. Kuwongolera kwapakati ndi koletsedwa.
Kwa makina, ma insulin, ma insulinge ena amakono amatha kugwiritsidwa ntchito. Insulin yapakatikati singagwiritsidwe ntchito pamapampu.
Isofan insulin ndi kuyimitsidwa, kotero mpweya umapangika pakapita nthawi pansi pa vial. Musanapange jakisoni, mankhwalawa amayenera kusakanizika bwino. Ngati sizingatheke kukwaniritsa mtundu umodzi wa kuyimitsidwa, insulin imasungidwa, ndipo singagwiritsidwe ntchito.
Tsamba labwino kwambiri la jekeseni ndi ntchafu. Amaloledwa kupereka jakisoni pamimba, matako, phewa -.
Pangani jekeseni yatsopano osachepera 2 cm kuchokera kumbuyomu. Mutha kubaya pamalo omwewo pakatha masiku atatu.

Ndemanga

Kukopera zinthu kuchokera pamalowa ndizotheka ndi ulalo wokha patsamba lathu.

CHIYAMBI! Zambiri patsamba lino ndizodziwika bwino ndipo sizitanthauza kuti zili zolondola kuchokera ku nkhani zamankhwala. Kuchiza kuyenera kuchitika ndi dokotala woyenera. Kudziziritsa nokha, mutha kudzipweteka!

Pharmacology

Isofan - insulin, ili ndi vuto la hypoglycemic. Imalumikizana ndi malekezero apadera a membrane wakunja wa cytoplasmic cell, chifukwa chomwe insulin receptor system imapangidwa. Zimathandizira kulimbikitsa njira zamagawo.

Chifukwa chakuti kusuntha kwa glucose mkati mwa maselo kumachuluka, kuchuluka kwake m'magazi kumatsika. Zotsatira zofananazo zimatheka pochepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera kuyamwa kwake ndi minofu.

Mankhwalawa amagwira ntchito kwanthawi yayitali chifukwa cha kuthamanga, komwe kumayendetsedwa ndi zinthu zingapo: momwe insulin imalowera (imatha kubayidwa m'mimba, ntchafu kapena matako), njira yoyendetsera, Mlingo.

Pambuyo pobweretsa insulin yaumunthu yopanga majini pansi pa khungu ndi jakisoni, kutseguka kwake kumachitika pambuyo pa ola limodzi ndi theka. Mankhwalawa amagwira ntchito kwambiri kuyambira 4th mpaka 12 koloko, amagwira ntchito masana.

Zinthu zotsatirazi zitha kuchitika chifukwa cha zofunikira za Isofan: samakhazikika mkaka wa amayi. Kugawa mu minofu sikofanana. Samadutsa placenta. Kuyambira 30 mpaka 80% amachotseredwa ndi impso.

Malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito amawunikira mtundu waukulu wamatenda omwe ma insulin omwe amapangidwira matendawa amagwiritsidwa ntchito - insulin yodalira shuga. Chithandizo mu izi zimachitika mu moyo wonse. Pankhaniyi, ndikofunikira kutsatira jakisoni. Kuphatikiza apo, Isofan imagwiritsidwa ntchito pa mtundu 1 ndi matenda ashuga 2.

Dokotala atha kukulemberani mankhwala ngati pali vuto kuchokera ku mankhwala omwe amachepetsa shuga. Kenako insulin imayikidwa ngati mankhwala osakaniza.

Kuwonjezeka kwa shuga m'magazi kungakhale chifukwa chazovuta, mwachitsanzo, pambuyo pakuchita opaleshoni. Pankhaniyi, insulin ikhoza kutumikiranso ngati chithandizo chovuta. Amalandira amayi apakati omwe ali ndi matenda ashuga.

Isofan imagwiritsidwa ntchito kokha pa mtundu 1 ndi matenda ashuga 2!

Mankhwalawa amadziwikiridwa kwa odwala omwe amatha kuyanjana ndi hypoglycemia.

Kutengera mphamvu

Zotsatira zoyipa za kutenga Isofan ndi:

Zotsatira zoyipa za kagayidwe kazakudya. Izi zikuwonetsedwa ngati mawonekedwe amkhungu pakhungu, thukuta kwambiri, kuthamanga mtima, mawonekedwe a kunjenjemera, munthu amafunitsitsa kudya, amakhala ndi chisangalalo chamanjenje, kupweteka kwa mutu pafupipafupi.
Chiwonetsero chofotokozedwa ndi zotupa pakhungu, edema ya Quincke. Nthawi zina, mankhwalawa amayambitsa anaphylactic.
Kutupa kumatha kuchitika.
Pambuyo jakisoni, kuyabwa kapena kutupa, kuvulala kumatha kuchitika. Ngati mankhwalawa amatha nthawi yayitali, lipodystrophy imapangidwa.

Pankhani imeneyi, kumayambiriro kwa chithandizo, chithandizo cha insulin chitha kuchitika pokhapokha poikidwa ndi dokotala komanso moyang'aniridwa.

Kugwiritsa Ntchito Mimba

Isofan imatha kugwiritsidwa ntchito pa nthawi yoyembekezera komanso HB, chifukwa sizilowa m'magazi a mwana kudzera mu placenta komanso mkaka. Mwa amayi omwe ali ndi matenda ashuga omwe amakhala ndi mwana, mankhwala a insulin ndiye njira yokhayo yochepetsera glycemia yomwe imaloledwa ku Russia.

Kufunika kwa mankhwalawa kwa miyezi 9 kumasintha mobwerezabwereza nthawi imodzimodzi ndi kusintha kwa mayendedwe mahomoni a mkazi, kotero muyenera kusinthitsa kawirikawiri mlingo wa insulin. Kuwongolera kwambiri shuga panthawi yoyembekezera ndi njira yofunikira yolepheretsera kusokonezedwa ndi kufa kwa fetal.

Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti kuyamwa kwa mapiritsi ndi insulini kwa nthawi yonse yokhayo ndi njira yokhayo yosungira shuga m'manja? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kuzigwiritsa ntchito.

Mlingo wowonjezera

Pankhani ya kuyambitsa kuchuluka kwa mankhwala, wodwalayo amatha kuwona zizindikiro za hypoglycemia. Poterepa, muyenera kudya chidutswa cha shuga kapena zakudya zopatsa mphamvu yamafuta ambiri. Itha kukhala ma cookie, madzi a zipatso, maswiti.

Kuyambitsa Isofan kwambiri kungachititse kuti musamale kwambiri. Ndikulimbikitsidwa kuti mupeze jakisoni wambiri wa 40% dextrose solution. Glucagon imatha kutumikiridwa intramuscularly, kudzera m'mitsempha kapena mozungulira.

Kuchita zamtanda

Malangizo ogwiritsira ntchito mankhwalawa amafotokozera mwatsatanetsatane mawonekedwe a mankhwalawo komanso mawonekedwe ake ogwiritsira ntchito.

Kapangidwe kamtundu wamtundu wa Isofan ndikogwira ntchito ngati mankhwala otsatirawa atengedwa nthawi yomweyo:

Hypoglycemic pamlomo wothandizira.
Mao ndi ACE zoletsa, carbonic anhydrase.
Sulfonamides.
Anabolikov.
Tetracyclines.
Mankhwala okhala ndi ethanol.

Kugwiritsa ntchito kwa Isofan kumachepa ndi kugwiritsa ntchito: Kulera kwapakamwa, mankhwala a glucocorticoid, mahomoni a chithokomiro, antidepressants, morphine. Ngati sizotheka kusiya mankhwala omwe amakhudza insulin, ndikofunikira kuchenjeza adokotala omwe akupezekapo.

Mankhwala ofanana

Odwala a shuga ali ndi chidwi chofunsa funso lomwe limatanthawuza insulin. Ndikulimbikitsidwa kugwiritsa ntchito fanizo lotsatira la Isofan pochiza: Humulin (NPH), Protafan-NM, Protafan-NM Penfill, Insumal, Actrafan.

Musanasinthe Isofan kukhala analog, ndikofunikira kufunsa dokotala. Mankhwala a insulin ndi chithandizo chachikulu. Zimafunikira kulangidwa ndi wodwalayo komanso zomwe dokotala akuwona.

About Isofan kwa Matenda A shuga

Pothana ndi matenda monga matenda ashuga, kuchuluka kwa mitundu ingapo ya mankhwala amagwiritsidwa ntchito. Chimodzi mwa izo ndi Isofan insulin, chomwe ndi mankhwala okhala ndi mawonekedwe apakatikati omwe amakhala pakatikati. Pazomwe zimapangidwira, ngati pali zotsutsana pazinthu zina pambuyo pake m'lembalo.

Isofan insulin imapezeka ndikugwiritsa ntchito matekinoloje monga kufananizira DNA. Iyi ndi njira imodzi yamakono. Iye, monga mukudziwa, akutsimikizira kuchuluka kwakukulu pazotheka kugwiritsa ntchito matenda a shuga a mtundu woyamba ndi wachiwiri.

Kuphatikizika kotere ndi chitsimikizo chenicheni kuti Isofan insulin idzakhudza odwala matenda ashuga m'njira zabwino kwambiri. Pankhani imeneyi, ndikofunikira kuzindikira zambiri zazokhudza zovuta zamankhwala.

Isofan insulin yotulutsira mawonekedwe

Kodi imalembedwa liti?

Malangizo ogwiritsira ntchito "Insulin-Isophan"

Contraindication

Zotsatira zoyipa

Kugwirizana

Zizindikiro zochuluka

Njira zopewera kupewa ngozi

Mitu ya mankhwalawa

Isofan insulin: malangizo ogwiritsira ntchito komanso mtengo wa mankhwalawa

Zizindikiro zogwiritsidwa ntchito ndi mayina ogulitsa a mankhwalawa

Zotsatira za pharmacological

Mlingo ndi makonzedwe

Insulin

Zochita za insulin

Kuchita ndi mankhwala ena

Njira yogwiritsira ntchito

Zotsatira zoyipa

Kutulutsa Fomu

Mankhwala

Zochita Zosiyanasiyana

Kutulutsa mafomu, mtengo wake

Zizindikiro ndi contraindication

Mimba komanso kuyamwa

Mndandanda wazofananira

Kugwirizana kwa chinthu insulin-isophan chibadwa chaumunthu chazinthu zina

Bongo

Zambiri, zikuonetsa kuti mugwiritse ntchito

Zizindikiro zogwiritsidwa ntchito

Kupanga ndi mawonekedwe a kumasulidwa

Kuchiritsa katundu

Zotsatira zoyipa ndi bongo

Insulin-isophan: malangizo ogwiritsira ntchito kuyimitsidwa

Chaka chomaliza kusintha

Zochita za Isofan

Zovuta ndi zoyipa

Momwe mungagwiritsire ntchito insulin?

Mukatenga isofan insulin

Hypoglycemia Chithandizo

Zokhudza zotsatira zamankhwala

Zokhudza mlingo

Zokhudza kusamala

Rinsulin PNH

Isofan Insulin ndi timadzi tating'onoting'ono topangidwa ndi anthu

Zimagwira bwanji?

Momwe mungagwiritsire ntchito: Zizindikiro zakugwiritsa ntchito

Isofan insulin: ndingagwiritse ntchito ndi mankhwala ena

Momwe mungasinthire: malangizo apadera

Mimba, mkaka wa m`mawere ndi insulin Isofan

Zizindikiro Isofan-Insulin World Cup

Mafotokozedwe a magulu a nosological

Humulin NPH

Isofan Insulin ndi timadzi tating'onoting'ono topangidwa ndi anthu

Isofan: analogu ndi mayina ena

Zimagwira bwanji?

Momwe mungagwiritsire ntchito: Zizindikiro zakugwiritsa ntchito

Isofan insulin: ndingagwiritse ntchito ndi mankhwala ena

Isofan insulin: mtengo

Momwe mungasinthire: malangizo apadera

Mimba, mkaka wa m`mawere ndi insulin Isofan

Zotsatira za pharmacological

Clinical Pharmacology

Zizindikiro Isofan-Insulin World Cup

Contraindication

Zotsatira zoyipa

Mlingo ndi makonzedwe

Njira zopewera kupewa ngozi

Zosungidwa za mankhwala Isofan-Insulin FM

Isofan-Insulin World Cup

Mafotokozedwe a magulu a nosological

Insulin Isofan Wothandiza Wodwala Matenda A shuga

Kutulutsa mafomu, mtengo wake

Zizindikiro ndi contraindication

Insulin-isophan: malangizo ogwiritsira ntchito kuyimitsidwa

Zizindikiro zogwiritsidwa ntchito

Kupanga ndi mawonekedwe a kumasulidwa

Kuchiritsa katundu

Njira yogwiritsira ntchito

Zotsatira zoyipa ndi bongo

Rinsulin PNH