Vasotens H (Vasotens® H)

Vazotens N: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Vasotenz H

Code ya ATX: C09DA01

Zogwira pophika: losartan (Losartan) + hydrochlorothiazide (Hydrochlorothiazide)

Wopanga: Actavis hf. (Iceland), Actavis, Ltd. (Malta)

Sinthani mafotokozedwe ndi chithunzi: 07/11/2019

Mitengo muma pharmacies: kuchokera ku 375 ma ruble.

Vazotens N ndi mankhwala ophatikiza antihypertensive.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi okhala ndi filimu: ozungulira, biconvex, omwe ali ndi zoopsa pangozi ndi mbali zonse ziwiri za piritsi, mbali imodzi ya zoopsa pamakhala zolemba "LH", inayo - "1" (kipimo 50 mg + 12.5 mg) kapena "2" (muyezo wa 100 mg + 25 mg) (mu chithuza cham'mapiritsi 7, 10 kapena 14.), pamakatoni a matuza 2 kapena 4 a mapiritsi 7, kapena 1, 3, 9 kapena 10 matuza a mapiritsi 10, kapena 1 kapena 3. 2 matumba a mapiritsi 14 ndi malangizo ogwiritsira ntchito Vazotenza N).

Piritsi 1:

• yogwira zigawo: losartan potaziyamu - 50 kapena 100 mg, hydrochlorothiazide - 12,5 kapena 25 mg, motero
• zotuluka: croscarmellose sodium, microcrystalline cellulose, mannitol, magnesium stearate, povidone, White Opadrai (hypromellose 50cP, hypromellose 3cP, titanium dioxide, macrogol, hydroxypropyl cellulose).

Mankhwala

Vazotens N ndi mankhwala ogwiritsira ntchito pamodzi.

Katundu wa zinthu zogwira:

• losartan ndi angiotensin II receptor antagonist (subtype AT1). Amachepetsa kuthamanga kwa magazi (BP), kuphatikizika kwathunthu kwamitsempha yamagazi (OPSS), kuthamanga kwa kufalikira kwam'mapapo, ndende ya adrenaline ndi aldosterone m'magazi, kumachepetsa kutsitsa, kumakhala ndi diuretic. Odwala omwe ali ndi vuto la mtima losalephera, amalepheretsa kukula kwa myocardial hypertrophy ndikuwonjezera kulolerako zolimbitsa thupi. Sikuletsa kinase II - puloteni yomwe imawononga bradykinin,
• hydrochlorothiazide ndi thiazide diuretic. Amachepetsa kukonzanso kwa ayoni a sodium, kumathandizira kuphipha kwa bicarbonate, phosphate ndi potonium ion mu mkodzo.

Chifukwa chake, Vazotens N imachepetsa kuchuluka kwa magazi, magazi amakonzanso khoma lamitsempha, kumathandizira kukhumudwa kwa ganglia, kumachepetsa kukanikiza kwa ma vasoconstrictors, potero kumachepetsa kuthamanga kwa magazi.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, losartan imatengedwa mwachangu m'matumbo amtumbo (GIT). Amadziwika ndi otsika bioavailability, chinthu

33% Imakhala ndi mphamvu yoyambira kudutsa m'chiwindi. Zimapangidwa ndi carboxylation, zomwe zimapangitsa kuti pakhale kupangika kwa metabolites osakanikirana komanso main pharmacologically yogwira metabolite (E-3174). Pafupifupi 99% ya mankhwalawa imamangiriza mapuloteni a plasma. Pambuyo pa kutenga Vazotenza N mkati, kuchuluka kwakukulu kwa losartan kumatheka mkati mwa ola limodzi, yogwira metabolite - maola 3-4. Hafu ya moyo (T_½) losartan - maola 1.5-2, E-3174 - maola 3-4. Amawonekera: kudzera m'matumbo - 60% ya mlingo, impso - 35%.

Pambuyo pakukonzekera kwamlomo, hydrochlorothiazide imatengedwa mwachangu m'mimba. Osapukusidwa mu chiwindi. T_½ - maola 5.8-14.8. Ambiri (

61%) amapukutidwa osasinthika mkodzo.

Contraindication

• kwambiri ochepa hypotension,
• kuvulala kwambiri aimpso QC (kuvomerezeka kwa creatinine) ≤ 30 ml / min,
• kukanika kwambiri kwa chiwindi,
• Hypovolemia (kuphatikiza pozungulira pamiyeso yambiri ya okodzetsa),
• anuria
• wazaka 18
• mimba ndi mkaka wa m`mawere
• Hypersensitivity kwa losartan, hydrochlorothiazide, mankhwala ena a sulfonamide kapena gawo lina lililonse la mankhwala.

Achibale (Vasotens N ayenera kugwiritsidwa ntchito mosamala):

• kuphwanya magazi-electrolyte bwino magazi (kuchepa madzi, hypochloremic alkalosis, hyponatremia, hypokalemia, hypomagnesemia),
• bilteryal aimpso mtsempha wamagazi kapena stenosis ya impso imodzi,
• hypercalcemia, hyperuricemia ndi / kapena gout,
• matenda ashuga
• Matenda matenda a minofu yolumikizira (kuphatikizapo zokhudza lupus erythematosus),
• mbiri yolephera,
• Mphumu ya bronchial,
• kugwiritsa ntchito munthawi yomweyo mankhwala osapweteka a antiidal (NSAIDs), kuphatikiza COX-2 inhibitors (cycloo oxygenase-2).

Zotsatira zoyipa

Mukamagwiritsa ntchito Vazotenza H, mavuto amatha kuchitika mukamamwa potaziyamu ndi / kapena hydrochlorothiazide.

Zotheka kuchitidwa:

• Kuchokera pamtima: kuchepa kwamphamvu kwa magazi,
• Kuchokera pamimba:: kawirikawiri (1%, chifukwa cha losartan monga gawo la mankhwala) - matenda otsekula m'mimba, chiwindi,
• mbali ya kupuma kwamphamvu: chifuwa (chifukwa cha wolowa),
• khungu ndi matupi awo sagwirizana: urticaria, angioedema (kuphatikizapo kutuluka kwa milomo, pharynx, larynx ndi / kapena lilime), zomwe zingayambitse kutsekeka kwa kupuma, osowa kwambiri (chifukwa cha losartan) - vasculitis, kuphatikizapo Matenda a Shenlein-Genoch,
• magawo a labotale: kawirikawiri - hyperkalemia (serum potaziyamu> 5.5 mmol / l), kuchuluka kwa michere ya chiwindi.

Ndi matenda oopsa kwambiri, zotsatira zoyipa kwambiri ndiz chizungulire.

Bongo

Ngati bongo wambiri, losartan angayambitse matenda otsatirawa: kuchepa magazi, bradycardia, tachycardia.

Mankhwala osokoneza bongo a hydrochlorothiazide amatha kuwonetsedwa ndi kuchepa kwa ma electrolyte (hyperchloremia, hypokalemia, hyponatremia), komanso kuchepa kwa madzi m'mimba, zomwe zimachitika chifukwa cha kuchuluka kwa diuresis.

Ngati papita nthawi pang'ono kuchokera pa kutenga Vazotenza N, kulimbikitsidwa kwa m'mimba ndikulimbikitsidwa. Chizindikiro chothandizira komanso chothandizira chimalembedwa; kukonza kukasokoneza kwamadzi pamafunika. Ngati ndi kotheka, hemodialysis imapangidwa kuti ichotse losartan ndi metabolite yake yogwira m'thupi.

Hydrochlorothiazide

Pa mankhwala, ndikofunikira kuwunika momwe wodwalayo alili kuti azindikire mwachangu zomwe zingachitike ndikusokonekera kwa madzi osakanikirana ndi ma electrolyte, omwe angachitike motsutsana ndi maziko akumimba kapena kusanza. Mu odwala oterowo, ndikofunikira kuti muwongolere kuchuluka kwa ma electrolyte mu seramu yamagazi.

Liazide diuretics imatha kusokoneza kulolerana kwa shuga, komwe kungafune kusintha kwa mlingo wa wothandizira wa hypoglycemic kapena insulin.

Hydrochlorothiazide itha kuchepa kwamkodzo calcium, komanso imapangitsa kuchulukana kwapadera kwa seramu. Ngati kwambiri hypercalcemia wapezeka, hypentparathyroidism yaposachedwa iyenera kulingaliridwa.

Thiazides amakhudza kagayidwe ka calcium, motero, amatha kupotoza zotsatira za kafukufuku wamagulu a ziwopsezo za parathyroid. Pankhaniyi, madzulo oyeserera, mankhwalawa ayenera kuti adathetsedwa.

Hydrochlorothiazide imatha kuwonjezera magazi triglycerides ndi cholesterol.

Pa mankhwala, kuchulukitsa kapena kupitilira kwa systemic lupus erythematosus ndikotheka.

Hydrochlorothiazide ikhoza kuyambitsa kukula kwa hyperuricemia ndi / kapena gout. Komabe, losartan, wachiwiri wogwira ntchito wa Vazotenza N, amachepetsa uric acid, motero, amachepetsa kuopsa kwa hyperuricemia chifukwa cha okodzetsa.

Poyerekeza maziko a diuretic mankhwala, zimachitika hypersensitivity zimachitika, ngakhale odwala ndi mbiri yopanda mphumu kapena chifuwa.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Kafukufuku wapadera wamankhwala kuti aphunzire za Vazotenza N pantchito yodziwitsa anthu komanso zama psychomotor sanachitike. Komabe, mukalandira chithandizo, chizungulire komanso kugona kumatha kuchitika. Pazifukwa izi, kusamala kumalangizidwa pamene mukugwira ntchito yomwe imafuna chidwi chochulukirapo komanso kuthamanga kwa zochita, makamaka pa gawo loyambirira la mankhwala komanso panthawi yowonjezera mlingo wa mankhwalawa.

Mimba komanso kuyamwa

Ikagwiritsidwa ntchito mu gawo lachiwiri komanso lachitatu lokonzekera kubereka, losartan, monga mankhwala ena omwe amakhudzanso renin-angiotensin-aldosterone system (RAAS), imatha kubweretsa chilema komanso ngakhale kufa kwa fetal.

Hydrochlorothiazide imawoloka chotchinga, imatsimikizika m'magazi a chingwe. Ikagwiritsidwa ntchito pa nthawi ya pakati, imawonjezera chiopsezo cha jaundice mwana wosabadwa kapena wakhanda, komanso thrombocytopenia ndi kusalingana kwa amayi.

Ma Vasotens N mapiritsi ali contraindicated pa mimba. Ngati amayi apezeka ndi pakati pa mankhwala ndi mankhwalawa, muyenera kusiya posachedwa.

Liazide diuretics imadutsa mkaka wa m'mawere. Mzimayi akulimbikitsidwa kusiya kuyamwitsa ngati chithandizo cha mankhwala pa mkaka wabwinobwino chiri chololeka.

Kuyanjana kwa mankhwala

Losartan ikhoza kugwiritsidwa ntchito limodzi ndi othandizira ena a antihypertensive (okodzetsa, achifundo, okhathamiritsa). Nthawi yomweyo, kulimbikitsana kwamathandizidwe kumadziwika.

Palibe mankhwalawa ofunikira omwe amagwiritsidwa ntchito ndi hydrochlorothiazide munthawi yomweyo, erythromycin, cimetidine, ketoconazole, phenobarbital, warfarin, digoxin.

Odwala omwe ali ndi BCC yochepetsedwa chifukwa chamankhwala am'mbuyomu, mankhwala amachititsa kuchepa kwa magazi.

Pogwiritsa ntchito potaziyamu poteteza mauretics (amiloride, triamteren, spironolactone), mchere wa potaziyamu kapena potaziyamu, kuchuluka kwa potaziyamu mu seramu yamagazi ndikotheka.

Fluconazole ndi rifampicin amachepetsa mphamvu ya plasma yogwira metabolite wa losartan. Kufunika kwachipatala pazothandizanazi sikunakhazikike.

Losartan amatha kuwonjezera zomwe zimapezeka mu lithiamu m'magazi. Pankhaniyi, kukonzekera kwa lithiamu kungathe kulembedwa pokhapokha kuwunika mosamala phindu lomwe likuyembekezeka komanso zoopsa zomwe zingachitike. Mukamagwiritsa ntchito kuphatikiza uku, plasma concentration ya lithiamu iyenera kuyang'aniridwa mosamala.

Zotsatira za losartan zitha kuchepetsedwa ndi NSAIDs, kuphatikiza kusankha COX-2 inhibitors. Odwala ndi mkhutu aimpso ntchito, nthawi zina, kuphatikiza uku kungathandizenso kuwonongeka kwa impso, mpaka kukula kwa impso kulephera. Izi nthawi zambiri zimatha kusintha.

Kupanga ndi mawonekedwe a kumasulidwa

mu paketi yazotupa 7 ma PC., mumapaketi okhala ndi makatoni 4, kapena papulasitala yonyamula ma 14 ma PC, mumtundu wa makatoni 2 matabwa.

mu paketi yazotupa 7 ma PC., mumapaketi okhala ndi makatoni 4, kapena papulasitala yonyamula ma 14 ma PC, mumtundu wa makatoni 2 matabwa.

Kuchita

Losartan imawonjezera mphamvu ya mankhwala ena a antihypertensive. Palibe kuyanjana kwakukulu ndi hydrochlorothiazide, digoxin, anticoagulants, cimetidine, phenobarbital, ketoconazole, erythromycin adadziwika. Rifampicin ndi fluconazole adanenedwa kuti achepetse kuchuluka kwa metabolite yogwira. Kufunika kwamankhwala pazothandizirana izi sikunaphunzire.

Monga kuphatikiza kwa mankhwala ena omwe amalepheretsa angiotensin II kapena machitidwe ake, makonzedwe apanthawi yomweyo a potaziyamu (mwachitsanzo, spironolactone, triamteren, amiloride), kukonzekera kwa potaziyamu, kapena m'malo mwa mchere omwe muli potaziyamu kungayambitse hyperkalemia.

NSAIDs, kuphatikiza kusankha COX-2 inhibitors kumatha kuchepetsa mphamvu ya okodzetsa ndi ena othandizira.

Odwala ena omwe ali ndi vuto la impso omwe amathandizidwa ndi NSAIDs (kuphatikizapo COX-2 inhibitors), chithandizo cha angiotensin II receptor antagonists chingayambitse kuwonongeka kwa ntchito yaimpso, kuphatikizapo kuperewera kwaimpso, komwe nthawi zambiri kumatha kusintha.

Mphamvu ya antihypertensive ya losartan, monga mankhwala ena a antihypertgency, imatha kufooka mukamamwa indomethacin.

Mankhwala otsatirawa amatha kuyanjana ndi thiazide diuretics ndi makonzedwe amodzi a iwo:

barbiturates, mankhwala osokoneza bongo, Mowa - orthostatic hypotension ikhoza kuyambitsa,

othandizira a hypoglycemic (pakamwa othandizira ndi insulin) - Kusintha kwa mankhwalawa kwa othandizira a hypoglycemic angafunike,

ma antihypertensives ena - zotsatira zowonjezera ndizotheka,

colestyramine ndi colestipol - kuchepetsa mayamwidwe a hydrochlorothiazide,

corticosteroids, ACTH - Kutaya kwakanayi kwamagetsi, makamaka potaziyamu,

ma Pressor amines - mwina kuchepa pang'ono kwakanthawi kwamankhwala opondaponda, osasokoneza kugwiritsa ntchito kwawo,

kupuma kosakhumudwitsa minofu (mwachitsanzo tubocurarine) - ndizotheka kupititsa patsogolo ntchito za opuma minofu,

Kukonzekera kwa lifiyamu - okodzetsa amachepetsa chilolezo cha Li + ndikuwonjezera chiopsezo cha kuyamwa kwa lithiamu, chifukwa chake, kugwiritsa ntchito munthawi yomweyo sikuloledwa.

NSAIDs, kuphatikiza kusankha COX-2 zoletsa - mwa odwala ena, kugwiritsa ntchito NSAIDs, kuphatikiza COX-2 zoletsa, zimachepetsa diuretic, natriuretic ndi antihypertensive zotsatira za okodzetsa.

Zokhudza zotsatira za labotale - Chifukwa cha kuchuluka kwa calcium calcium, thiazides amatha kuthana ndi zotsatira za kusanthula kwa ntchito ya parathyroid.

Mlingo ndi makonzedwe

Mkati ngakhale chakudyacho.

Pulogalamu yoyamba komanso yokonza piritsi ndi piritsi limodzi. patsiku. Kwa odwala omwe sangathe kukwaniritsa kuthamanga kwa magazi pa mlingo, mankhwalawa amatha kuwonjezereka kwa mapiritsi awiri. (50 mg / 12.5 mg) kapena piritsi limodzi. (100 mg / 25 mg) nthawi imodzi patsiku. Mlingo waukulu ndi mapiritsi awiri. (50 mg / 12.5 mg) kapena piritsi limodzi. (100 mg / 25 mg) nthawi imodzi patsiku.

Pazonse, kufalikira kwakukulu kumachitika mkati mwa masabata atatu atayamba chithandizo.

Palibe chifukwa chosankhidwa mwapadera kwa mlingo woyambirira wa odwala okalamba.

Malangizo apadera

Itha kuperekedwa limodzi ndi mankhwala ena a antihypertensive.

Palibe chifukwa chosankhira mtundu woyambirira wa odwala okalamba.

Mankhwala atha kuwonjezera kuchuluka kwa urea ndi creatinine m'madzi am'magazi mwa odwala omwe ali ndi impso yamitsempha yamafupa kapena aimpso a stenosis a impso imodzi.

Hydrochlorothiazide imatha kuwonjezera kuchepa kwa magazi komanso kuchepa kwa magazi m'magazi a electrolyte (kuchepa kwa BCC, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), kufooketsa shuga, kuchepetsa kuchepa kwa calcium ndipo kumapangitsa kuchepa, kuwonjezeka pang'ono kwa calcium mafuta ambiri. ndi triglycerides, yambitsa kupezeka kwa hyperuricemia ndi / kapena gout.

Kulandiridwa kwa mankhwala omwe akukhudzidwa ndi dongosolo la renin-angiotensin panthawi ya II ndi III trimesters ya mimba kungayambitse imfa ya fetal. Ngati kutenga pakati kumachitika, kuchotsedwa kwa mankhwala kumasonyezedwa.

Palibe chidziwitso pakuyendetsa galimoto ndi zina.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amalembedwa kwa odwala omwe ali ndi mavuto osiyanasiyana:

1. Matenda oopsa. Mankhwala akuwonetsedwa kwa odwala matenda oopsa. Ngakhale kumwa mankhwalawa "Vazotens" ndikofunikira kuwunikira pafupipafupi zowonetsa magazi.
2. Kulephera kwamtima kosalekeza. Ndi kukula kwa matenda amtunduwu, mgwirizano wamtima umachepa mwa odwala. Nthawi zambiri, matendawa amakumana ndi okalamba.

Mankhwala "Vazotens" adayikidwa limodzi ndi mankhwala ena. Mankhwalawa amalekeredwa bwino ndikumatenga ndi ACE zoletsa. Dokotala amayenera kudziwa kuthandizira kwa mankhwalawa komanso machitidwe a thupi.

Mankhwalawa amalembera mtima kulephera

Momwe mungatengere ndi kukakamiza, mulingo

"Vazotens" amawonetsedwa kwa odwala omwe ali ndi kuthamanga kwa magazi. Mankhwala amatengedwa pakamwa, ngakhale chakudyacho. Muyenera kumwa mapiritsi 1 kamodzi patsiku.

Ngati odwala adapezeka kuti ali ndi matenda oopsa, mankhwalawa amayamba ndi kuchuluka. Wodwala ndi mankhwala a 50 mg a losartan. Ngati ndi kotheka komanso malinga ndi umboni wa dotolo, mlingowo ukhoza kuwonjezeka mpaka 100 mg. Kenako nambalayi imagawidwa pawiri - m'mawa ndi madzulo.

Anthu omwe ali ndi vuto la mtima ayenera kumwa mankhwala ochepa. Mlingo woyambirira ndi 12,5 mg kamodzi patsiku. Ngati wodwalayo amalola kulandira chithandizo bwino, patatha masiku 7-10 mlingo umachuluka.

Pharmacology

Mankhwala a Vazotens amatanthauza antihypertensive mankhwala - osokoneza ena a angiotensin 2 receptors. Sipondereza kinase enzyme, yomwe imawononga bradykinin. Mankhwala ali ndi diuretic kwambiri, samakhudza zomwe adrenaline, aldosterone mu plasma.

Chifukwa cha momwe mankhwalawa amachitikira, matenda oopsa a m'mitsempha yamagazi samatulutsa, kulekerera zolimbitsa thupi kumawonjezeka ndi kulephera kwa mtima. Pakadutsa kamodzi mapiritsi, kupanikizika kumachepa, mphamvu imafika pazomwe itatha maola 6 ndipo imatha tsiku. Kuchita bwino kwa mankhwalawa kumawonetsedwa pa masabata a 3-6. Ndi cirrhosis ya chiwindi, kugwiritsidwa ntchito kwa zinthu zomwe zimagwira, kumawonjezera, motero kusintha kwa mlingo kumafunika.

Losartan imalowa mwachangu m'mimba, imakhala ndi 33% bioavailability. Thunthu limafika pazipita ndende pambuyo pa ola limodzi, yogwira metabolite - pambuyo maola 3-4. Hafu ya moyo wa losartan ndi maola 1.5-2, metabolite ndi maola 6-9. Gawo limodzi mwa magawo atatu a mankhwalawa limachotsedwa mu mkodzo, ena onse ndi ndowe.

Kapangidwe ka Vazotenza N kamaphatikizidwa ndi diuretic hydrochlorothiazide, yomwe imanena za chinthu cha mtundu wa thiazide. Amachepetsa kubwezeretsanso kwa ayoni a sodium, kumawonjezera kuphipha kwa mkodzo phosphates, bicarbonate. Pakuchepetsa kuchuluka kwa magazi ozungulira, kupanikizika kumachepa, kuyambiranso kwa kusintha kwa khoma la mtima, mphamvu yama Pressor ya vasoconstrictors imatsika, komanso kukhumudwa kwa ganglia kumawonjezeka.

Mlingo ndi makonzedwe

Mapiritsi a Vazotens amatengedwa kamodzi patsiku. Ndi matenda oopsa, mlingo wa tsiku ndi tsiku ndi 50 mg, nthawi zina umachulukitsidwa mpaka 100 mg mu Mlingo wa 1-2. Pakulephera kwa mtima, mlingo woyambirira ndi 12,5 mg kamodzi patsiku. Mlingo umachulukitsidwa sabata iliyonse ndi 12.5 mg kuti ufike 50 mg kamodzi patsiku. Ndi munthawi yomweyo makonzedwe a okodzetsa, koyamba mlingo amachepetsa 25 mg tsiku.

Pankhani ya chiwindi kuwonongeka ntchito (utachepera kulengedwa kwa creatinine), mlingo umachepa, muukalamba, ndi kulephera kwa impso, kudzimbidwa, kukonza sikumachitika. Kuchuluka kwake kumawonekera pambuyo pa milungu itatu yamankhwala. Mu ana, mankhwalawa sagwiritsidwa ntchito. Malangizo apadera ogwiritsira ntchito malangizo:

1. Musanalembe mankhwala, kukonza magazi m'thupi kumachitika, kapena muyenera kugwiritsa ntchito mankhwalawa.
2. Chidacho chitha kuwonjezera kuchuluka kwa urea m'magazi ndi aimpso stenosis.
3. Pa mankhwala, ndikofunikira kuwongolera kuchuluka kwa potaziyamu m'magazi, makamaka okalamba, popeza odwala oterewa ali ndi chiopsezo chowonjezereka cha hyperkalemia (kuchuluka kwa potaziyamu m'magazi a magazi).
4. Kugwiritsa ntchito mankhwalawa panthawi yapakati kumatha kubweretsa chitukuko kapena kufa kwa fetal. Pa mkaka wa m`mawere, kugwiritsa ntchito vasotens koletsedwa.

Migwirizano yogulitsa ndikusunga

Vazotens amatanthauza mankhwala omwe mumalandira, omwe amasungidwa kutentha mpaka madigiri 30 osapitirira zaka ziwiri, kuchokera kwa ana.

Ma antihypertensive othandizira omwe ali ndi mawonekedwe ena amatha kusintha mankhwalawa. Ma analogi a Vazotens:

• Lorista - mapiritsi ozikidwa pa losartan,
• Lozap ndimakonzedwe apiritsi okhala ndi losartan ngati chinthu chogwira ntchito.

Dzinalo Lopanda Padziko Lonse

INN yamankhwala ndi losartan.

Mankhwala a Vasotens nthawi zambiri amaperekedwa kwa anthu odwala matenda oopsa.

Mu gulu la padziko lonse la ATX, mankhwalawa ali ndi code C09CA01.

Kutulutsa mafomu ndi kapangidwe kake

Chofunikira chachikulu cha Vazotens ndi potaziyamu losartan. Zina mwa mankhwalawa zimaphatikizira croscarmellose sodium, mannitol, hypromellose, magnesium stearate, talc, propylene glycol, etc. Kapangidwe ka Vazotenza N, kuwonjezera pa losartan, kumaphatikiza hydrochlorothiazide.

Vasotens amapezeka mu mawonekedwe a mapiritsi okhala ndi 25-25, 50 ndi 100 mg. Mapiritsiwa amawazunguliza. Amakutidwa ndi chipolopolo choyera ndipo amatchedwa "2L", "3L" kapena "4L" kutengera mlingo. Amayika m'matumba a 7 kapena 10 ma PC. Mu bokosi la makatoni pamakhala matuza 1, 2, 3 kapena 4 ndi pepala lophunzitsira lomwe lili ndi chidziwitso cha mankhwalawa.

Vasotens amapezeka mu mawonekedwe a mapiritsi okhala ndi 25-25, 50 ndi 100 mg.

Zotsatira za pharmacological

Mankhwala omwe amapezeka pamankhwala amachokera chifukwa cha ntchito yotchedwa Vazotenz, yomwe ndi yofunika kwambiri yomwe ndi mtundu 2 angiotensin receptor antagonist. Ndi mankhwala a vasotenz, mankhwala omwe amagwira ntchito amathandizira kuchepetsa OPSS. Mankhwala amachepetsa kuchuluka kwa aldosterone ndi adrenaline m'madzi a m'magazi. Mankhwalawa ali ndi mphamvu yophatikiza, amathandizira pakuthamanga kwa kukakamizika kwa kufalikira kwa mapapu ndi kufalikira kwa m'mapapo.

Kuphatikiza apo, magwiritsidwe ake a mankhwalawa amachepetsa kulemera kwa mtima ndipo amakhala ndi tanthauzo la diuretic. Chifukwa cha zovuta zake, kulandira mankhwala a vasotens kumachepetsa chiopsezo cha myocardial hypertrophy. Mankhwalawa amathandizira kukulitsa kulolera kwa odwala omwe ali ndi zizindikiro zazikulu zakulephera kwa mtima.

Mankhwalawa saletsa kuphatikizira kwa mtundu 2 kinase. Enzyme iyi imatha kuwononga bradykinin. Mukamamwa mankhwalawa, kuchepa kwa magazi kumawonedwa pambuyo pa maola 6. M'tsogolomu, ntchito ya mankhwala omwe amapezeka pang'onopang'ono amachepera maola 24. Ndi kugwiritsa ntchito mwadongosolo, mphamvu yake yayikulu imawonedwa pambuyo pa masabata 3-6. Chifukwa chake, mankhwalawa amafunika kugwiritsa ntchito nthawi yayitali.

Ndi chisamaliro

Ngati wodwala ali ndi vuto la chiwindi ndi impso, chithandizo cha Vazotens chimafuna kuthandizidwa ndi dokotala. Kuphatikiza apo, chisamaliro chapadera chimafuna kugwiritsa ntchito vazotens pochiza anthu omwe akudwala matenda a Shenlein Genoch. Pankhaniyi, kusintha pafupipafupi kwa mlingo wa mankhwalawa kumafunikira kuti muchepetse ngozi zakukula kwambiri.

Kodi kumwa vasotens?

Mankhwalawa amapangidwira pakamwa. Kuti mukwaniritse zochizira, wodwalayo ayenera kumwa 1 nthawi ya m'mawa. Kudya sizikhudzana ndi mayamwa. Kuti akhazikitse kuthamanga kwa magazi ndikuisunga bwino, odwala amawonetsedwa kumwa Vazotenza pa mlingo wa 50 mg patsiku. Ngati ndi kotheka, mlingo utha kuwonjezeka mpaka 100 mg patsiku.

Ngati wodwala ali ndi vuto la mtima kulephera, pang'onopang'ono kuchuluka kwa vasotenz ndikofunikira. Choyamba, wodwalayo amapatsidwa mankhwala pa mlingo wa 12,5 mg wa patsiku. Pakupita pafupifupi sabata limodzi, mlingo umawonjezeka mpaka 25 mg. Pambuyo masiku ena 7 a kumwa mankhwalawa, mlingo wake umakwera mpaka 50 mg patsiku.

Ngati wodwala ali ndi vuto la kukanika kwa chiwindi, kulandira chithandizo cha Vazotens kumafuna chidwi ndi dokotala.

Pakati mantha dongosolo

Pafupifupi 1% ya odwala omwe ali ndi vuto la vasotens ali ndi zizindikiro za asthenia, kupweteka mutu, komanso chizungulire. Kusokonezeka tulo, kugona tulo, kutopa mtima, zizindikiro za ataxia ndi zotumphukira neuropathy nthawi zina kumatha kuchitika pa nthawi ya mankhwala a vasotenz. Kuchepetsa kukomoka ndi kuwonongeka kwa mawonekedwe. Kuphatikiza apo, pamakhala chiwopsezo cha kumva zolimbitsa miyendo.

Kuchokera ku genitourinary system

Kutenga vasotenza kungapangitse kuti pakhale matenda opatsirana kwamkodzo. Nthawi zina, odwala amakhala ndi madandaulo a kukodza pafupipafupi komanso kuwonongeka kwa impso. Mwa amuna, omwe ali ndi vasotenz mankhwala, kuchepa kwa libido ndi kukula kwa kusabala kungawoneke.

Mwina kuoneka ngati khungu louma.

Kuchokera pamtima

Ndi yaitali vasotenz mankhwala, wodwalayo akhoza kuyamba orthostatic hypotension. Angina ndi tachycardia kuukira ndikotheka. Nthawi zina, kumwa mankhwalawa kumayambitsa magazi m'thupi.

Nthawi zambiri, kugwiritsidwa ntchito kwa vasotenz kumayambitsa zovuta zomwe zimakhudzana ndi kuyabwa, urticaria, kapena zotupa pakhungu. Kawirikawiri sanawone kukula kwa angioedema.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Kuchita bwino ndi chitetezo cha kugwiritsa ntchito vasotenza pa nthawi ya pakati sikunaphunzire konse. Poterepa, pali umboni wa zotsatira zoyipa za mankhwala omwe ali pa mwana wosabadwayo mu 2nd ndi 3 trimester ya mimba. Izi zimawonjezera chiopsezo cha mwana kukulira zovuta zina ndi kufa kwa intrauterine. Ngati chithandizo chikufunika, kukana kuyamwitsa kungalimbikitsidwe.

Ndi yaitali vasotenz mankhwala, wodwalayo akhoza kuyamba orthostatic hypotension.

Mtengo wa vasotens

Mtengo wa mankhwalawa m'mafakisoni umachokera ku ma ruble 115 mpaka 300, kutengera mlingo.

Imodzi mwa zodziwika bwino za mankhwalawa ndi Lozap.
Cozaar ndi analogue ya mankhwala a Vazotens.
Mankhwala ofanana ndi a Presartan.
Analogue ya mankhwala a Vazotens ndi a Lorista.Lozarel ndi amodzi mwa odziwika bwino a mankhwala a Vazotens.

Omvera zamtima

Grigory, wazaka 38, Moscow

Pazachipatala changa, nthawi zambiri ndimalemba ntchito za vazotens kwa odwala omwe ali ndi matenda oopsa. Chifukwa cha kuphatikiza kwa hypotensive ndi diuretic kwenikweni, mankhwalawa samangothandizira kuthamanga kwa magazi, komanso amathandizira kulolerana kwa masewera olimbitsa thupi ndikuchepetsa zovuta za edema. Mankhwalawa amaloledwa ngakhale ndi odwala okalamba. Kuphatikiza apo, ndioyenera kuphatikizidwa ndi zovuta zovuta kugwiritsa ntchito mankhwala owonjezera a antihypertensive.

Irina, wazaka 42, Rostov-on-Don.

Ndakhala ndikugwira ntchito ya mtima kwa zaka zopitilira 15, ndipo odwala omwe amalandila madandaulo a kuthamanga kwa magazi nthawi zambiri amapereka mankhwala a Vazotens. Zotsatira za mankhwalawa nthawi zambiri ndizokwanira kukhala ndi mavuto osaneneka popanda kufunika kophatikiza ma diuretics. Mankhwalawa amavomerezedwa bwino ndi odwala ndipo nthawi zambiri samayambitsa mavuto. Chifukwa cha izi, mutha kugwiritsa ntchito bwino m'maphunziro atali.

Igor, wazaka 45, Orenburg

Nthawi zambiri ndimalimbikitsa kugwiritsa ntchito vasotenza kwa odwala omwe ali ndi vuto la mtima. Mankhwala amakupatsani mwayi kufatsa matenda a magazi ndi kuchepetsa kuopsa kwa edema yam'munsi malekezero. Chida chimayenda bwino ndi mankhwala ena omwe amagwiritsidwa ntchito pochiza matenda amtunduwu. Pazaka zanga zambiri zoyeserera, sindinakumanepo ndi mawonekedwe a zovuta zoyipa mwa odwala omwe amagwiritsa ntchito vazotens.

Mukamagwiritsa ntchito mankhwalawa, chisamaliro chimayenera kuthandizidwa kuti muthane ndi njira zovuta.

Margarita, wa zaka 48, Kamensk-Shakhtinsky

Ndakhala ndikudziwa vuto la kuthamanga kwa magazi kwa zaka zoposa 15. Poyamba, madokotala ankalimbikitsa kuchepetsa kunenepa, kuyenda pafupipafupi ndi mpweya wabwino komanso kudya moyenera, koma pang'onopang'ono vutoli limakulirakulira. Kupanikizika kudayamba kukhazikika pa 170/110, madokotala adayamba kupereka mankhwala. Zaka 3 zapitazi ndidathandizidwa ndi Vazotens. Chidacho chimapereka zotsatira zabwino. Ndimatenga m'mawa. Kupanikizika kwakhazikika. Kutupa kwamiyendo kunazimiririka. Anayamba kumva bwino kwambiri. Ngakhale kukwera masitepe kumaperekedwa tsopano popanda kufupika.

Andrey, wazaka 52, Chelyabinsk

Anamwa mankhwala osiyanasiyana pokakamiza. Pafupifupi chaka chimodzi, katswiri wa mtima adamuwuza kugwiritsa ntchito vazotens. Chidacho chimapereka zotsatira zabwino. Muyenera kumwa kamodzi kokha patsiku. Kupanikizika kunabweranso kwawokha pakangotha ​​milungu iwiri yokha. Tsopano ndimamwa mankhwalawa tsiku lililonse. Sindinawone zotsatira zoyipa.