Glimekomb - (Glimekomb) malangizo ogwiritsira ntchito

Fomu ya Mlingo - mapiritsi: flat-cylindrical, kuyambira yoyera mpaka yoyera yokhala ndi zonona kapena zotuwa zachikasu (mtundu wakubowoleza ndi zotheka), ndi notch ndi bevel (ma PC 10. Mumapaketi a contour cell, mu bokosi la makatoni 6 mapaketi, 20 ma PC. matuza, m'makatoni olembetsa matumba 5, 30, 60 ndi ma pcs a 120. m'mabotolo apulasitiki, mu bokosi lamatabwa 1

Zinthu zomwe zimagwira piritsi limodzi:

• metformin hydrochloride - 500 mg,
• gliclazide - 40 mg.

Zowonjezera: croscarmellose sodium, povidone, magnesium stearate, sorbitol.

Zizindikiro zogwiritsidwa ntchito

• lembani matenda ashuga a 2 ngati vuto la chakudya likukula, zochitika zolimbitsa thupi komanso monotherapy yapita ndi gliclazide kapena metformin,
• lembani matenda ashuga a 2 a shuga okhala ndi khola lama glucose oyenera komanso olamulidwa bwino - kuti musinthe chithandizo chotsatira cham'mbuyomu ndi mankhwala awiri (gliclazide ndi metformin).

Contraindication

• achina,
• matenda ashuga ketoacidosis, matenda a shuga komanso chikomokere,
• mtundu 1 shuga
• kulephera kwa chiwindi
• matenda owopsa komanso osachiritsika omwe amatsatana ndi minofu hypoxia: kulowetsedwa kwaposachedwa kwam'mimba, kupuma komanso kulephera kwa mtima, kugwedezeka,
• Zovuta kwambiri zomwe zingayambitse kusintha kwa impso: matenda owopsa, kuchepa thupi, mantha,
• kuvulala kwambiri aimpso,
• lactic acidosis, kuphatikizapo mbiri ya
• matenda opatsirana, kupsa kwambiri, kuvulala, kulowererapo kwakukulu ndi zina zomwe zimafuna chithandizo cha insulin,
• porphyria
• kuledzera kwadzaoneni, uchidakwa wopitirira,
• kutsatira zakudya zochepa zama calori (zosakwana 1000 calories / tsiku),
• nthawi ya pakati komanso yoyamwitsa,
• kuchita mayendedwe a radioisotope kapena X-ray ndikumayambitsa masiyanidwe okhala ndi ayodini pakati (maola 48 asanafike ndi maola 48 pambuyo pake),
• kugwiritsa ntchito miconazole,
• Hypersensitivity aliyense wogwira kapena othandizira pazinthu zina za mankhwala kapena zotumphukira zina za sulfonylurea.

Glimecomb siyikulimbikitsidwa kwa odwala azaka zopitilira 60 omwe amagwira ntchito zolimbitsa thupi (chifukwa choopsa chotenga lactic acidosis).

• matenda a chithokomiro ndikuphwanya ntchito yake,
• kuperewera kwa adrenal,
• febrile syndrome
• hypofunction wa anterior pituitary England.

Mlingo ndi makonzedwe

Glimecomb iyenera kumwedwa pakamwa kapena mutangomaliza kudya.

Dokotalayo amawona mlingo payekhapayekha, kutengera kuchuluka kwa shuga m'magazi.

Mlingo woyamba wa tsiku ndi tsiku, monga malamulo, ndi mapiritsi atatu, ndiye kuti umachulukana pang'onopang'ono, ngati pangafunike, mpaka kubwezeretsedwa kwakukhazikika kwa matendawo kungachitike.

Pazipita tsiku lililonse mapiritsi 5.

Mlingo wa tsiku ndi tsiku nthawi zambiri umagawidwa mu 2 Mlingo - m'mawa ndi madzulo.

Zotsatira zoyipa

• thupi lawo siligwirizana: zotupa za maculopapular, kuyabwa, urticaria,
• kuchokera kumbali ya kagayidwe: kudya kosakwanira ndi kuphwanya njira ya dosing - hypoglycemia (njala, mutu, kutopa, kufooka kwambiri, chizungulire, kuchuluka kwa thukuta, kusokonezeka kwa minyewa, kusokonekera kwa kayendedwe, palpitations, ndi kupitirira kwa hypoglycemia - kulephera kudziletsa komanso kuzindikira) , nthawi zina - lactic acidosis (kupweteka kwam'mimba, kupuma, kutsika magazi, kugona, myalgia, kufooka, hypothermia, Reflex bradyarrhythmia),
• Kuchokera kwa ziwalo za hemopoietic: kawirikawiri - zoletsa za m'mafupa hematopoiesis (thrombocytopenia, anemia, leukopenia),
• Kuchokera pamimba: kuperewera kwa chakudya, kusowa kwa chakudya mkamwa, kutsegula m'mimba, mseru, kumva kupweteka kwa epigastrium), kawirikawiri - kuwonongeka kwa chiwindi (kuchuluka kwa ntchito ya hepatic transaminases ndi alkaline phosphatase, cholestatic jaundice, hepatitis),
• Zina: kuchepa kwa mawonekedwe.

Zotsatira za sulfonylureas, zomwe zimaphatikizapo chimodzi mwazomwe zimagwira mu Glimecomb (glyclazide), zimatha kuyambitsa zotsatirazi: alculgic vasculitis, hemolytic anemia, agranulocytosis, pancytopenia, erythropenia, ndi chiwopsezo cha chiwopsezo cha moyo.

Pakakhala mankhwala osokoneza bongo komanso pakubwera kwa zinthu zoopsa chifukwa cha metformin yomwe ili gawo lamankhwala, kupanga lactic acidosis ndikotheka - chikhalidwe chofunikira kuchipatala mwadzidzidzi (Zizindikiro zake zalongosoledwa pamwambapa). Chithandizo chikuyenera kuchitika kuchipatala. Chithandizo chothandiza kwambiri pavutoli ndi hemodialysis.

Komanso, bongo wambiri ungayambitse kukula kwa hypoglycemia, chifukwa gliclazide ndi gawo limodzi la mankhwalawa. Ndi kufatsa kwambiri kwamphamvu kwa hypoglycemia, shuga (dextrose) uyenera kutumikiridwa kapena yankho la shuga lotengedwa pakamwa. Mu kwambiri hypoglycemia (yowonetsedwa ndi kusazindikira) 40% shuga (dextrose) jakisoni umalowetsedwa kudzera m'mitsempha, glucagon kapena intramuscularly. Wodwalayo akayambanso kuzindikira, amafunika kupatsidwa chakudya chopatsa thanzi kuti alepheretse kukonzanso kwa hypoglycemia.

Malangizo apadera

Glimecomb imangoperekedwa kwa odwala omwe amalandila chakudya chochepa chamafuta, omwe amaphatikizapo chakudya cham'mawa.

Pa chithandizo, muyenera kuwunika kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya, makamaka masiku oyamba a kumwa mankhwalawa.

Glimecomb iyenera kuyimitsidwa maola 48 isanayambike kulowetsedwa kwa ayodini wokhala ndi radiopaque wothandizila kapena kuchitira opaleshoni. Mutha kuyambiranso kutenga osapitirira 48 maola.

Tiyenera kukumbukira kuti sulfonylurea zotumphukira (panthawiyi, glyclazide) zimatha kupangitsa hypoglycemia, nthawi zina kukhala koopsa komanso kwanthawi yayitali. Nthawi zambiri, izi zimayamba ndi chakudya chamafuta ochepa, pambuyo poyeserera kuchita masewera olimbitsa thupi, titamwa mowa, komanso tikamamwa mankhwala angapo a hypoglycemic. Popewa kukula kwa hypoglycemia, ndikofunikira kusankha mosamala komanso payekhapayekha wodwala aliyense ndikupereka chidziwitso chokwanira chamankhwala omwe akubwera.

Mlingo wa Glimecomb uyenera kusinthidwa posintha zakudya, ndi nkhawa komanso thupi.

Magulu otsatirawa odwala ali ndi chidwi chachikulu ndi machitidwe a mankhwala a hypoglycemic:

• odwala ndi pituitary-adrenal kuchepa,
• okalamba
• anthu omwe samadya mokwanira,
• odwala omwe ali ofooka kwambiri.

Njala, mowa ndi mankhwala osokoneza bongo omwe amalimbana ndi kutupa zimawonjezera ngozi ya hypoglycemia.

Guanethidine, reserpine, clonidine ndi beta-blockers amatha kuphimba zizindikiro za matenda a hypoglycemia.

M'matenda opatsirana omwe ali ndi febrile syndrome, kuwotcha kwakukulu, kuvulala komanso kuchitapo kanthu kwakukulu pakuchita opaleshoni, Kuchepetsa kwa Glimecomb ndi kuikidwa kwa insulin. Pa mankhwalawa, ndikofunikira kuyang'anira kuwonongeka kwa impso ndipo nthawi zina (osachepera 2 pachaka) kudziwa lactate mu plasma. Pankhani ya lactic acidosis, ndikofunikira kuletsa mankhwalawa.

Pokonzekera kutenga pakati komanso ngati zimachitika panthawi yogwiritsa ntchito mankhwalawa, ndikofunikira kusiya kumwa ndikupereka mankhwala a insulin.

Pa mankhwala, mowa umaletsedwa. Chenjezo liyenera kuchitidwa poyendetsa galimoto ndikuchita ntchito zoopsa zomwe zimafunikira chidwi chochulukirapo, kuthamanga kwa malingaliro ndi magalimoto.

Kuyanjana kwa mankhwala

Mphamvu ya Gloglycemic ya Glimecomb imalimbikitsidwa ndi othandizira ena a hypoglycemic (mwachitsanzo, insulini, acarbose, biguanides), tubular secretion blockers, sulfonamides omwe amakhala nthawi yayitali, blockers N₂histamine cholandilira muzikangana (mwachitsanzo cimetidine), coumarin anticoagulants, antifungal wothandizila (fluconazole, miconazole), zoletsa Ace (enalapril, captopril), beta-blockers, salicylates, nonsteroidal odana ndi yotupa mankhwala (oxyphenbutazone, azapropazone, phenylbutazone), monoamine oxidase zoletsa , anti-TB mankhwala (ethionamide), fibrate (clofibrate, bezafibrate), anabolic steroids, oxytetracycline, fenfluramine, disopyramide, tetracycline, guanethidine, fluoxetine, c cyclophosphamide, allopurinol, reserpine, chloramphenicol, pyridoxine, theophylline, pentoxifylline, bromocriptine.

kanthu Hypoglycemic Glimekomba kufooketsa carbonic zoletsa anhydrase (acetazolamide), thiazide okodzetsa, lifiyamu, odana ndi khunyu mankhwala (phenytoin), chithokomiro mahomoni blockers pang'onopang'ono kashiamu njira, steroids barbiturates, agonists (Epinephrine, clonidine), rifampicin, baclofen, chlorthalidone, diazoxide, furosemide, glucagon, isoniazid, triamteren, terbutaline, morphine, katsitsumzukwa, salbutamol, danazol, ritodrin, muyezo waukulu - pakamwa kulera, estrogens, chlorpromazine, nikotini hydrochloric acid.

Mankhwala omwe amalepheretsa mafupa a hematopoiesis kuonjezera mwayi wa myelosuppression, Mowa - kukula kwa lactic acidosis.

Pankhani yophatikiza ndi mtima glycosides, Glimecomb imawonjezera chiopsezo cha ventricular extrasystole.

Nifedipine imakulitsa mayamwidwe ndikuchepetsa kuchotsedwa kwa metformin.

Pogwiritsa ntchito nthawi yayitali, cationic othandizira omwe amatulutsidwa m'matubu (procainamide, amiloride, vancomycin, quinidine, digoxin, triamteren, morphine, ranitidine) amawonjezera kuchuluka kwa metformin m'magazi ndi 60%, furosemide - 22%.

Metformin imachepetsa ndende yambiri ndi theka la moyo wa furosemide ndi 31 ndi 42.3%, motero.

Kutulutsa mawonekedwe, ma CD ndi mawonekedwe a Glimecomb ®

Mapiritsi kuyambira oyera mpaka oyera okhala ndi kirimu wowawasa kapena wachikasu, masilinda osalala, okhala ndi chamfer ndi chiwopsezo, kuguba kumaloledwa.

Othandizira: sorbitol, povidone, croscarmellose sodium, magnesium stearate.

Ma PC 10 - matumba a matuza (6) - mapaketi a makatoni.

Zotsatira za pharmacological

Mankhwala osakanikirana a hypoglycemic ophatikizidwa pakamwa. Glimecomb ® ndi kuphatikiza kosakanikirana kwamamawu awiri a gulu la Biguanide ndi gulu la sulfonylurea.

Ili ndi pancreatic ndi extrapancreatic kanthu.

Glyclazide ndi wochokera ku sulfonylurea. Imathandizira kubisika kwa insulin ndi kapamba, kumapangitsa chidwi cha zotumphukira kwa insulin. Imalimbikitsa ntchito ya intracellular michere - minofu glycogen synthetase. Amabwezeretsa chimfine choyambirira cha insulin, imachepetsa nthawi kuyambira pakudya mpaka pakuyamba kwa insulin, ndikuchepetsa hyperglycemia ya postprandial. Kuphatikiza pa kukhudza kagayidwe kazakudya, kumakhudza ma cellcirculation, kuchepetsa kupendekera ndi kuphatikizika kwa maselo, kuchedwetsa kukula kwa parietal thrombosis, kufooketsa kupezeka kwamitsempha yama cell ndipo kumalepheretsa kukula kwa michere yam'mimba, komanso kubwezeretsa kusintha kwa thupi. Imachepetsa kukula kwa matenda ashuga retinopathy osagwirizana, ndi matenda ashuga a nephropathy omwe amagwiritsidwa ntchito kwa nthawi yayitali, kuchepa kwakukulu kwa proteinuria kumadziwika. Siziwonjezera kukwera kwa thupi, chifukwa imakhala ndi mphamvu pakadutsa katemera wa insulin ndipo samayambitsa hyperinsulinemia, imathandizira kuchepetsa kulemera kwa odwala onenepa kwambiri, kutsatira zakudya zoyenera.

Metformin ndi m'gulu la Biguanides. Amachepetsa kuchuluka kwa shuga m'magazi mwa kuletsa gluconeogeneis m'chiwindi, kuchepetsa kuyamwa kwa glucose m'mimba yamagetsi ndikukulitsa kugwiritsidwa ntchito kwake mu minofu. Amachepetsa ndende ya triglycerides, cholesterol ndi LDL (yotsimikizika pamimba yopanda kanthu) mu seramu yamagazi ndipo sasintha kuchuluka kwa lipoproteins a kachulukidwe kosiyanasiyana. Imathandizira kukhazikika kapena kuchepetsa thupi. Pakakhala insulin m'magazi, chithandizo cha mankhwala sichikuwonetsedwa. Hypoglycemic zimachitika sizimayambitsa. Amawongolera michere yamagazi ya fibrinolytic chifukwa cha kuponderezedwa kwa choletsa wa activator profibrinolysin (plasminogen).

Mafotokozedwe a magulu a nosological

Pharmacokinetics

Zogulitsa ndi kugawa

Pambuyo pakukonzekera pakamwa, mayamwidwe amakhala okwera. Mukamamwa mlingo wa 40 mg C max m'magazi am'magazi amatha pambuyo maola 2-3 ndipo amafikira ku 2-3 μg / ml. Kuphatikiza kwa mapuloteni a Plasma ndi 85-97%.

Kutetemera ndi chimbudzi

Wopangidwira m'chiwindi. T 1/2 - maola 8 mpaka 20. Amakumbidwa makamaka mu mawonekedwe a metabolites ndi impso - 70%, kudzera m'matumbo - 12%.

Odwala okalamba, kusintha kwakukulu pamawonekedwe a pharmacokinetic sikuwonetsedwa.

Zogulitsa ndi kugawa

Pambuyo pakamwa, mayamwidwe ndi 48-52%. Amamwa mwachangu kuchokera mumimba. Mtheradi bioavailability (pamimba yopanda kanthu) ndi 50-60%. C max m'madzi a m'magazi amafikira pambuyo pa 1.81-2.69 h ndipo osapitilira 1 μg / ml. Kulandila ndi chakudya kumachepetsa C max mu plasma ndi 40% ndikuchepetsa kukwaniritsa kwake ndi mphindi 35. Kumanga kwa mapuloteni a Plasma ndikosatheka. Metformin imatha kudziunjikira m'magazi ofiira.

T 1/2 ndi maora 6.2. Imadziwikanso ndi impso, osasinthika (kusefera kwa glomerular ndi katulutsidwe ka tubular) komanso m'matumbo (mpaka 30%).

Mitengo mumaofesi a mankhwala ku Moscow

Siyani ndemanga yanu

Chidziwitso Chaposachedwa Chosowa Chidziwitso, ‰

Zikalata Zolembetsa Glimecomb ®

• LSR-009886/09

Webusayiti yovomerezeka ya kampani RLS ®. Ensaikulopediya yayikulu ya mankhwala osokoneza bongo ndi katundu wa assortment yaku Russia. Ndondomeko yamankhwala Rlsnet.ru imapatsa ogwiritsa ntchito malangizo, mitengo ndi mafotokozedwe a mankhwala, zowonjezera zakudya, zida zamankhwala, zida zamankhwala ndi zina. Maupangiri a pharmacological akuphatikiza chidziwitso cha kapangidwe ndi mawonekedwe amamasulidwe, zochitika zamankhwala, zisonyezo zogwiritsidwa ntchito, contraindication, zotsatira zoyipa, kuyanjana kwa mankhwala, njira yogwiritsira ntchito mankhwala, makampani opanga mankhwala. Ndondomeko ya mankhwala ili ndi mitengo yamankhwala ndi mankhwala ku Moscow ndi mizinda ina ya Russia.

Sizoletsedwa kufalitsa, kukopera, kufalitsa zambiri popanda chilolezo cha RLS-Patent LLC.
Mukamagwiritsa ntchito zidziwitso zofalitsidwa pamasamba a webusayiti ya www.rlsnet.ru, kulumikizana ndi gwero lachidziwitso ndikofunikira.

Zinthu zina zambiri zosangalatsa

Maumwini onse ndi otetezedwa.

Kugwiritsa ntchito malonda pazinthu sikuloledwa.

Chidziwitsochi cholinga chake ndi akatswiri azachipatala.

Kugwiritsa

Glimecomb tikulimbikitsidwa kuti mugwiritse ntchito kwa odwala omwe ali ndi matenda a shuga a 2. Ndikofunika kuti mankhwalawa amayesedwa ngati matenda amtunduwu pamene zochitika zolimbitsa thupi ndi mapu osakanikirana omwe sanapange zotsatira zoyenera. Izi zikutanthauza kuti mankhwalawa amadziwitsidwa ngati mankhwalawa sanagwire bwino ntchito, kuphatikiza mankhwala awiri (omwe nthawi zambiri amalekanitsidwa ndi metformin ndi gliclazide) limodzi ndi zolimbitsa thupi komanso zakudya.

Panthawi ya chithandizo ndi Glimecomb, kuyang'anira kuchuluka kwa shuga m'magazi musanadye chakudya ndikofunikira (chidwi chofunikira chiyenera kulipira sabata yoyamba kuvomerezeka).

Kutulutsa Mafomu

Glimecomb ili ndi mawonekedwe amodzi otulutsira mawonekedwe a mapiritsi. Mankhwalawa amagawidwa ndi njira yodzilongedza m'magulu otsatirawa:

• m'mabotolo apulasitiki mumatakata. Vala imodzi yamtunduwu imakhala ndi mapiritsi 30, 60 kapena 120,
• M'bokosi lamatoni okhala ndi matuza 10 mapiritsi 10 amodzi. Phukusi limodzi lili ndi matuza 6,
• M'bokosi lamatoni okhala ndi matuza a mapiritsi 20 amodzi. Phukusi limodzi lokhala ndi matuza 5.

Mapiritsi pawokha ali ngati silinda yathyathyathya, nthawi zambiri yoyera (beige, marble kapena chikasu ndi zovomerezeka). Mapiritsi ali ndi chiopsezo komanso zokongoletsa. Kuphatikizidwa kwa Glimecomb kumaphatikizapo metformin ndi hydrochloride mu 500 mg, komanso glycoslide 40 mg. Kuphatikiza apo, povidone, magnesium stearate, sorbitol ndi croscarmellose sodium imakhalapo yaying'ono.

Zisonyezero za mankhwala Glimecomb ®

• lembani matenda ashuga 2 a mellitus (osadalira insulini) osagwiritsa ntchito mankhwalawa pakudya, masewera olimbitsa thupi ndi chithandizo cham'mbuyomu ndi metformin kapena gliclazide,
• M'malo mwa chithandizo cham'mbuyomu ndi mitundu iwiri ya mankhwala (metformin ndi gliclazide) mwa odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga (osagwirizana ndi insulin) omwe ali ndi khola komanso magazi olamulidwa bwino.

Malangizo ogwiritsira ntchito

Glimecomb anatengedwa pakamwa, atangodya kapena nawo, kutengera mlingo. Panthawi ya mankhwalawa ndi mapiritsi, muyenera kutsatira zakudya zamafuta ochepa omwe amalimbikitsidwa ndi akatswiri, omwe ayenera kuphatikizapo chakudya cham'mawa. Mlingo wa mapiritsi uganizire osati kuchuluka kwa matenda a shuga a mtundu wachiwiriwo, komanso mkhalidwe wamalingaliro ndi wokhudza wodwalayo. Komanso, kusintha kulikonse pakudya kumafuna kuti muzilumikizana ndi dokotala (kusala komanso kuledzera sikuvomerezeka). Ndikofunikira kusunga mankhwalawo pamalo owuma, amdima pamtunda wa kutentha kuposa 25 digiri Celsius. Alumali moyo 2 zaka.

Tiyenera kukumbukira kuti mankhwala a sulfonylurea omwe amapezeka mu mankhwala amatha kuyambitsa hypoglycemia. Kuti mupewe izi, kusankha mosamala mlingo ndi zakudya za aliyense payekha ndikofunikira. Pa chithandizo, chisamaliro chapadera chiyenera kutengedwa poyendetsa galimoto ndi ntchito yofunikira kwambiri ndikuwonetsetsa.

Mlingo

Mankhwalawa amatengedwa pakamwa pakudya kapena atangodya. Mlingo wa mankhwalawa umatsimikiziridwa ndi dokotala aliyense payekha kwa wodwala aliyense, kutengera kuchuluka kwa shuga.

Mlingo woyambira nthawi zambiri umakhala mapiritsi atatu / tsiku ndi kusankha pang'ono pang'onopang'ono mpaka pokhazikika pobweza matendawa. Pazipita tsiku lililonse mapiritsi 5.

Nthawi zambiri mankhwalawa amatengedwa 2 kawiri / tsiku (m'mawa ndi madzulo).

Zotsatira zoyipa

Zotsatira zosayenera zomwe mungakumane nazo mutatenga Glimecomb nthawi zambiri zimafotokozedwa chifukwa cha kugwiritsidwa ntchito kwake kosagwirizana kapena kusagwirizana ndi thupi la wodwalayo. Ndipo zomwe zili sulfonylurea zotumphukira zimawonjezera chiopsezo cha zovuta zambiri. Kusankhidwa kwa minyewa yolakwika kwa wodwalayo kumawonekera ndikukula kwa lactic acidosis, limodzi ndi migraines, kufooka kosalekeza, kugona kwambiri, komanso kupweteka kwam'mimba komanso kuchepa kwa mavuto m'mitsempha.

Zotsatirazi ndi zotheka zosagwiritsidwa ntchito mukatenga Glimecomb:

• kukula kwa hypoglycemia ndi lactocidosis ndi zizindikiro zonse zopweteka,
• maonekedwe a m'mimba ndi kusilira,
• kusamva kosasangalatsa pamimba,
• kuchepa kwa chakudya
• mawonekedwe a magazi amkamwa ndi pakhosi,
• kukula kwa matenda oopsa a chiwindi (hepatitis, etc.) ndikosowa
• thupi lawo siligwirizana pa zigawo zikuluzikulu za mankhwala (urticaria, kuyabwa, zotupa,
• redness, mitundu yosiyanasiyana ya totupa),
• pali zochitika zowonongeka pomwe mukutenga Glimecomb.

Ngati muli ndi zomwe tafotokozazi, muyenera kufunsa katswiri nthawi yomweyo.

Mukutsogolera malo ogulitsa aku Russia, mtengo wa Glimecomb umasiyanasiyana kuchokera ku 200 mpaka 600 ma ruble, kutengera kuyika ndi kuchuluka kwa mapiritsi omwe alimo, komanso kwa omwe amapereka ndi dera lomwe likugulitsidwa. Mtengo wa mankhwalawa umapangitsa kuti anthu azikhala nawo ochuluka, ndipo chifukwa chake pamsika wamankhwala. Chifukwa chake mtengo wamba m'masitolo a pa intaneti a mapiritsi a Glimecomb ndi 40 mg + 500 mg 450 rubles pa phukusi lililonse, omwe ali ndi mapiritsi 60. Pamafesi amtundu wa intaneti, mtengo wa mankhwalawa mapiritsi 60 uzikhala 500-550 rubles.

Ma analogi a Glimecomb ndi awa:

• Gliformin (pafupifupi ma ruble 250 a mapiritsi 60), momwe amagwirira ntchito ndi ofanana ndi a Glimecomb, kapangidwe kake kamafanana, koma kukhalapo kwa insulin kumapangitsa kuti mankhwalawa akhale osawoneka bwino,
• Diabefarm (pa mapiritsi 60, muyenera kulipira pafupifupi ma ruble 150). Ili ndi kuchuluka kwamphamvu kwa glyclazide - 80 mg, cholinga chake ndikuchotsa mavuto omwewo monga Glimecomb.
• Gliclazide MV (mtengo wamba wa mapiritsi 60 ndi ma ruble 200). Ili ndi mawonekedwe osiyana ndi Glimecomb, imangokhala ndi 30 mg ya glycoslazide. Zizindikiro zogwiritsidwa ntchito ndizofanana ndi mankhwala oyamba.

Bongo

Ngati bongo wa Glimecomb, lactacidosis ndi hypoglycemia zimachitika. Pofuna kuthana ndi izi, hemodialysis nthawi zambiri imayikidwa. Glycemia imafunika kugwiritsa ntchito shuga kapena njira yothetsera shuga mkati (modekha kapena pang'ono). Mochulukirapo, mpaka kukayika, njira ya glucose 50% iyenera kuperekedwa (ingathe m'malo mwa glucagon). Wodwala akangoyamba kudziwa, ndikofunikira kuti amupatse chakudya chamafuta ambiri kuti aletse kupitirira kwa hypoglycemia.

Komanso, ngati kuledzera kwa mankhwala kumachitika popanda zovuta zambiri, wodwalayo akhoza kumva kuti salinso mu mawonekedwe a chizungulire mpaka kukomoka, mseru, kubanika ndi kutsegula m'mimba, komanso kupukusira kwa migraines. Pankhaniyi, muyenera kugwiritsa ntchito thandizo lanu nthawi yomweyo. Kunyumba, ndikofunikira kuti muzitsuka zam'mimba ndikuchotsa mankhwalawo nthawi yomweyo m'mimba, kenako ndi chakudya chamafuta ambiri. Ngati ndi kotheka, kugonekedwa kuchipatala ndikotheka kuyang'aniridwa ndi katswiri.

Mphamvu ya mankhwalawa pakuwongolera kuchuluka kwa shuga m'magazi a shuga a mtundu wachiwiri, komanso mtengo wake wokwanira, zimapangitsa kuti mankhwalawo akhale otchuka komanso kulandira ndemanga zambiri zabwino. Koma musaiwale za zovuta zomwe zimaperekedwa ndi mankhwalawa. Ndi chifukwa cha mndandanda waukulu wazovuta zomwe zimapangitsa kuti malingaliro oyipa a odwala apezeke. Pansipa pali ndemanga zina zokhudza mapiritsi awa:

Glimecomb, monga momwe amasonyezera, ndi mankhwala otchuka kwambiri pochiza matenda a shuga a 2. Kuphatikizidwa kwa mtengo, ubora komanso kukwera kwambiri kumapangitsa kuti mapiritsi akhale okongola m'misika yamapulogalamu.

Zotsatira zoyipa

Kuchokera ku dongosolo la endocrine: hypoglycemia (kuphwanya malamulo a dosing ndi chakudya chokwanira) - kupweteka m'mutu, kumva kutopa, njala, kutuluka thukuta, kufooka kwambiri, kulumikizana, chizungulire, kusokonekera kwa kayendedwe, kusokonezeka kwa minyewa kwakanthawi, ndi kupitirira kwa hypoglycemia, kulephera kudziletsa kumatha, kulephera kudziwa.

Kuchokera kumbali ya kagayidwe: nthawi zina - lactic acidosis (kufooka, myalgia, kupuma, kugona, kugona m'mimba, hypothermia, kuchepa kwa magazi, bradyarrhythmia).

Kuchokera pamiyambo ya m'mimba: dyspepsia (nseru, kutsegula m'mimba, kumva kupweteka kwa epigastrium, kukoma kwa "chitsulo" mkamwa), kutsika ndi chidwi (zovuta zakuchitikazo zimachepa ndi mankhwalawa ndikudya), hepatitis, cholestatic jaundice (kusiya mankhwala kumachitika) , kuchuluka kwa hepatic transaminases, zamchere phosphatase.

Kuchokera hemopoietic dongosolo: kawirikawiri - zoletsa za m'mafupa hematopoiesis (magazi m'thupi, thrombocytopenia, leukopenia).

Thupi lawo siligwirizana: kuyabwa, urticaria, zotupa za maculopapular.

Zina: kuchepa kwa mawonekedwe.

Pazifukwa zoyipa, mankhwalawa amayenera kuchepetsedwa kapena kugwiritsidwa ntchito kwa mankhwalawo kwakanthawi.

Zotsatira zoyipa zina za sulfonylurea zotumphukira: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, alculgic vasculitis, chiwopsezo cha chiwindi.