Magazi a cholesterol amachepetsa

Izi ndizofunikira kwathupi lathu. Ndi gawo limodzi lamatumbo onse am'matumbo ndi ziwalo. Koma nthawi yomweyo, cholesterol ikhoza kuvulaza thupi. Ndi zochulukirapo, zimatha kuyambitsa chiwonetsero cha atherosulinosis, zimakhudza mitsempha yambiri ndikupanga zolembera ndi cholesterol pa iwo.

Kodi cholesterol ndi chiyani?

Ndi anthu ochepa omwe amadziwa kuti cholesterol ndi chiyani. Koma izi sizimawaletsa kuganiza kuti ndizowopsa mthupi.

Ndiye cholesterol ndi chiyani? Umenewu ndi mowa wambiri. Imapezeka m'mitundu yonse yamatumbo a nyama ndi anthu. Cholesterol imathandiza kuti maselo azikhala otetezeka komanso kuwateteza kuti asawonongeke.

Chifukwa chake, musanamukalipira, muyenera kumvetsetsa zabwino zake.

Zothandiza pazinthu

Choyamba, chinthu ichi chimapezeka mkaka wa m'mawere. Ana ang'ono samamufuna iye monga ena. Ndikofunikira pakukula koyenera ndikukula kwa chitetezo chamthupi cha mwana.

Kuphatikiza apo, cholesterol imatithandiza kuthana ndi zida zopitilira muyeso, komanso kukalamba msanga kwa thupi.

Mothandizidwa ndi izo, vitamini D amapangidwa, komanso mahomoni ogonana ndi a steroid. Cholesterol imakhala yofunikira kwambiri muubongo, makamaka pakupanga kwake ndikusamalira bwino ntchito yake.

Zimachitanso gawo lalikulu pachitukuko cha chitetezo chamthupi.

Zingavulaze bwanji?

Kuphatikiza pazabwino zake, cholesterol imatha kuvulaza thupi. Choopsa chagona chifukwa chakuti chinthuchi sichimachotsedwa m'thupi, koma chimatengedwera m'makoma amitsempha yamagazi ndikuchiyika ziwalo zambiri.

Ngati mukufuna thandizo kuchokera kwa katswiri munthawi yake, mutha kuthana ndi vutoli mpaka kalekale. Dokotala amalimbikitsa mankhwala ndi zinthu zomwe zimatsitsa cholesterol.

Koma ngati chithandizo sichinayambike munthawi yake, izi zitha kubweretsa kukalamba kwa thupi, sitiroko komanso mtima.

Chifukwa chiyani cholesterol ikukwera?

Zomwe zimapangitsa kuti chiwonjezere ichi chiwonjezeke. Tikambirana zofala kwambiri:

• Matenda amtundu
• Matenda a impso ndi chiwindi
• Zizolowezi zoipa
• Moyo wopanda ntchito
• Kudya zakudya zamtunduwu
• Zopangira
• Kulemera kwambiri.

Chifukwa chake, kuchokera pamenepa tingaganizire kuti chinthu chomwe chimayambitsa kupezeka kwa matendawa sikuti ndimangokhala wopanda chakudya, komanso moyo wopanda ntchito.

Mukayamba kuyang'anitsitsa mulingo wa chinthucho m'magazi, ndizomwe mungapewe matenda ambiri.

Zakudya Zomwe Zimatha Kukweza Cholesterol yamagazi

Chifukwa chake, kuti mupange menyu yoyenera, muyenera kudziwa zinthu zomwe zimatha kuwonjezera zinthu izi. Ndipo sikuti ndi mafuta okhaokha, ngakhale amatenga malo mndandanda.

Mndandanda wazakudya zomwe siziyenera kumwa pafupipafupi:

• Margarine Amagwiritsidwa ntchito muzakudya zambiri, makamaka kuphika.
• Soseji, soseji ndi nyama zam'chitini.
• Zogulitsa monga chiwindi, mitima, impso, ndi ma ventricles. Ngakhale ambiri akukhulupirira kuti izi ndizakudya zakudya, kwenikweni, izi siziri choncho.
• Onse nsomba zamzitini.
• Mafuta.
• Mazira a nkhuku, omwe ndi yolk.
• Tchizi ndi batala,
• Shirimp

Kuphatikiza apo, musaiwale za zakudya zomwe mumakonda kwambiri - zakudya, ketchups, mayonesi, etc.

Zizindikiro

Dziwani kuchuluka kwa cholesterol ndikotheka pokha poyeza magazi. Madotolo ambiri amalangizidwa kuti aziwunika zaka zitatu zilizonse kwa aliyense, kupatula, anthu azaka zopitilira 20.

Kuti zotsatira zake zikhale zodalirika kwambiri, muyenera kutsatira malamulo ndi malingaliro ena:

• Magazi amatengedwa pamimba yopanda kanthu. Chakudya chomaliza chimayenera kukhala pafupifupi maola 12 mayeso ake asanachitike.
• Mutha kumwa madzi okha kapena tiyi wokoma.
• Masiku angapo musanayesedwe osavomerezeka kuti amwe zakumwa zoledzeretsa.
• Tsiku lisanaperekedwe, simungagwiritse ntchito mankhwala aliwonse, koma ngati kuli kofunikira, muyenera kuchenjeza dokotala.
• Musanagonjere, muyenera kukhala pansi modekha pafupi ndi ofesi kwa mphindi pafupifupi 15.
• Masiku angapo asanabadwe, zakudya zamafuta onse ndi zakudya zina zoyipa ziyenera kusiyidwa m'zakudya.
• Palibe kusuta komwe kumaloledwa ola limodzi isanachitike.

Pansipa pali zikhalidwe zofunika za cholesterol kwa munthu wamkulu:

• Kwa akazi 3 - 5.5 mmol / l,
• Kwa amuna, 3.5 - 6 mmol / L.

Ngati kupatuka pang'ono kuzizolowereka kwapezeka, ndiye izi ziyenera kuonedwa ngati matenda.

Kodi ndiyenera kupita kwa dokotala uti?

Poyamba, muyenera kulumikizana ndi chipatala komwe mumakhala ndikulembetsa kwa akatswiri akudziko. Ndiye amene alembe malangizo omwe angawongolere kuwunikaku. Ngati kuchuluka kwa mankhwalawa kuli kokulirapo, muyenera kufunsa katswiri wazakudya. Adzatha kulimbikitsa zinthu zomwe zithandizira kuchepetsa izi. Ngati atherosclerosis yakula motsutsana ndi maziko awa, ndiye akatswiri ena angakuthandizeni kuthana ndi izi: mtima, katswiri wa zamitsempha kapena opaleshoni ya mtima.

Mankhwala

Dokotala yekha ndi amene angatchule mankhwala enaake kuti athetse magazi m'thupi. Osamachita zisudzo zamatenda, apo ayi zitha kutha zomvetsa chisoni.

Mankhwala othandiza komanso odziwika bwino omwe angaperekedwe aperekedwa pansipa:

• Gemfibrozil (mayina ena ndi Gavilon, Dopur, Gipoliksan, Lipigem, Liposid, Lopid, Normolip). Mankhwalawa ndi oopsa. Amapezeka m'mitundu iwiri: makapisozi ndi mapiritsi. Amamulembera 0,3 - 0,45 magalamu kawiri pa tsiku kwa mwezi umodzi. Mankhwalawa ali contraindified mu mimba, ana ndi anthu omwe ali ndi matenda a ndulu. Nthawi zambiri mankhwalawa amalekeredwa bwino, koma nthawi zina, mavuto monga matenda am'mimba, kupweteka kwam'mimba, nseru, ndi kuchepa magazi nthawi zina.
• Cholestyramine. Amapezeka yekha mu ufa. Kuphwanya kwakukulu: anthu opitilira zaka 60, mimba, kutsekeka kwa biliary thirakiti. Mlingo weniweni wa mankhwalawo ukhoza kuperekedwa ndi adokotala. Zochitika zovuta mutamwa mankhwalawa: kutsekula m'mimba, kusanza kapena kudzimbidwa.
• Atorvastatin. Kutulutsa Fomu - mapiritsi okhala ndi chipolopolo choyera. Imakhala ndi zotsutsana zingapo: zaka mpaka zaka 18, pakati ndi mkaka wa m'mawere, kulephera kwa chiwindi, hypersensitivity kwa mankhwala. Mankhwalawa ali ndi mndandanda wazotsatira zoyipa, chifukwa musanagwiritse ntchito, muyenera kufunsa dokotala.

• Rosuvastatin. Amapezeka mu mapiritsi okhala ndi 5 mg, 10 mg, 20 mg ndi 40 mg. Amayenera kutengedwa pakamwa, osafuna kutafuna, kutsukidwa ndi madzi. Mutha kuudya nthawi iliyonse masana komanso osadya. Asanayambe kumwa mankhwalawa, wodwalayo ayenera kukhala pachakudya cha hypocholesterolemic, ndikupitilizabe kutsatira nthawi yonse ya chithandizo. Mlingo wa mankhwalawa umasankhidwa payekha ndi dokotala wopita. Mankhwalawa ali ndi mndandanda wokwanira wa zotsutsana ndi zoyipa zake, chifukwa chake simuyenera kupereka nokha popanda kuonana ndi katswiri.

Kumbukirani kuti ngati zotsatira zoyipa zikuchitika, muyenera kusiya kumwa mankhwalawo ndikuonana ndi dokotala. Katswiriyo amachepetsa mlingo kapena kupereka mankhwala ena.

Momwe mungachepetse cholesterol pogwiritsa ntchito mankhwala achikhalidwe?

Zomera zambiri zimathandizira kuthana ndi izi. Pansipa pali maphikidwe a mankhwala achikhalidwe chothandiza kwambiri polimbana ndi matenda awa.

Chinsinsi 1. Kuti tikonzekere mankhwalawa, timafunika mizu ya dandelion, kapena m'malo mwake, maluwa a maluwa. Tsiku lililonse ndikofunikira kugwiritsa ntchito 1 tsp. pamaso chakudya chilichonse. Ilibe zotsutsana, chinthu chokhacho ndikuti zotsatirazi zikuwoneka miyezi isanu ndi umodzi yokha pambuyo pogwiritsa ntchito mankhwalawa.

Kuchiritsa kulowetsedwa kwa cyanosis. Kuti tikonze, timafunikira supuni 1 yam'mera, yomwe iyenera kudzazidwa ndi kapu imodzi yamadzi. Ikani chidebecho ndi zomwe zili pamoto ndikuphika kwa theka la ola. Chotsatira, muyenera kusiya msuzi kuti ukhale wozizira, ulisefa ndi kutenga supuni imodzi yamadzulo mukatha kudya komaliza (pambuyo pa maola 2) kapena musanagone. Msuzi uwu umachotsa zinthu zonse zoyipa mthupi.

Choyeretsa chodabwitsa kwambiri mitsempha yamagazi ya cholesterol tincture wa phula. Mutha kuphika nokha, kapena mutha kugula kale okonzeka mu pharmacy network. Iyenera kutengedwa kanayi pa tsiku kwa mphindi 30 mkatewo usanadye. Pre-tincture uyenera kuchepetsedwa mu 30 ml ya madzi.

Mafuta a Garlic. Mungamupezenso m'sitolo, koma kawirikawiri. Bwino iphike nokha. Pophika, tengani mitu itatu ya adyo, isuleni ndikuphika pa grater yabwino. Kenako ndikusunthira ku botolo lagalasi ndikutsanulira 200 ml ya mafuta a mpendadzuwa pamenepo. Finyani madzi pang'ono kuchokera mandimu ndikuwonjezera pazomwe tili. Ikani botolo mufiriji kwa sabata limodzi. Tengani mankhwalawa ayenera kukhala 1 tsp. musanadye kamodzi pa tsiku kwa miyezi iwiri.

Beet kvass. Kupanga zakumwa izi nokha ndi kosavuta. Ndikofunikira kutenga mizu 4 yaying'ono-yayikulu muzu, muzimutsuka bwino, kenako ndikuyoboola. Kenako, beets iyenera kudulidwa m'magawo akulu ndikuyika mu mtsuko wagalasi. Kenako timatenga njerwa ya mkate wakuda, kuchotsa zinyalala, kudula ndi kuyika beets. Onjezani kapu ya 1⁄2 pachakudya cha mtsuko ndipo mudzaze chilichonse ndi madzi pamwamba. Phimbani mtsukowo ndi chofufumira ndikumayendayenda kwa sabata limodzi. Popita nthawi, kvass imasefedwa, amamwa 200 ml katatu patsiku. Chakumwa chotere sichiyenera kumwa kwa anthu omwe ali ndi vuto la m'mimba komanso zilonda zam'mimba, komanso zimaphatikizidwa mu matenda a impso.

Kutsitsa cholesterol ndi oats. Kuti tikonzekere bwino, timafunikira kapu imodzi ya tirigu ndi 800 ml ya madzi. Mafuta amapakidwa mosamala ndikusambitsidwa. Kenako amadzaza ndi thermos, kuthira madzi otentha ndikusiya, motero, usiku. M'mawa wotsatira osakaniza umasefedwa ndipo umatengedwa m'mimba yopanda chikho chimodzi cha kulowetsedwa. Kulowetsedwa kwatsopano kuyenera kukonzekera tsiku ndi tsiku. Njira ya mankhwala ndi chida ichi ndi masiku 14.

Kvass kuchokera ku yellifer. Pophika, muyenera kutenga 60 magalamu a udzu wosankhidwa kuti muike chikwama cha gauze, munganikize pang'ono kulemera kuti mudzaze onse ndi malita atatu a madzi. Kenako onjezerani kapu imodzi ya shuga ndi 1 tsp. wowawasa zonona. Timayika chidebe pamalo otentha, tsiku lililonse zomwe zili mkati ziyenera kusakanizidwa kwa masabata awiri. Imwani zakumwa zoterezi ziyenera kukhala 100 ml katatu pakugogoda kwa theka la ola musanadye. Onjezerani ku tanki madzi osowa ndi 1 tsp tsiku lililonse. Shuga Njira ya mankhwala ndi mwezi umodzi.

Njira zopewera

Mutha kupewa ma pathologies osiyanasiyana ogwirizana ndi cholesterol yayikulu. Muyenera kutsatira malamulo osavuta ndi malingaliro:

• Ndikofunikira kuyang'anitsitsa kuchuluka kwa cholesterol m'magazi, chifukwa izi ndizokwanira kukayezetsa magazi kamodzi pachaka, zomwe zimakupatsani mwayi wolamulira.
• Idyani zipatso ndi masamba ambiri momwe mungathere. Zomwe amachita tsiku ndi tsiku ndi 1500 kg pa munthu aliyense.
• M'malo mwa tiyi wamba, brew idakwera m'chiuno, sikuti imangolimbitsa kuchuluka kwa chinthucho m'magazi, komanso bwino bwino chitetezo chamthupi.
• Idyani mafuta a adyo kamodzi pa tsiku.
• Imwani madzi ambiri momwe mungathere.
• Idyani shuga wochepa.

Nyama yofiyira imasinthidwa bwino ndi nsomba zam'nyanja (kupatula shirimpu), yomwe ndi nsomba zam'nyanja ndi nkhono. Muli zinthu zomwe zimathandizira kuti mafuta azichoka mu cholesterol m'maselo ndi ziwalo zamkati.

Mukamaonera vidiyo, muphunzira za cholesterol.

Cholesterol sikuti imangoyipa m'thupi, komanso yopindulitsa. Kumbukirani kuti matenda amtunduwu alibe zizindikiro ndi zizindikiro. Mafuta a cholesterol amatha kuwongoleredwa ndi kusanthula. Katswiriyo amathandizira kuti akhazikitsenso ndipo ngati atasinthira pang'ono, akupatseni mankhwala omwe ali oyenera kwa inu. Osadzilimbitsa, zotsatirapo zake zimakhala zoipa kwambiri. Mukangoyamba chithandizo, mungathe kupewa matenda ena.

Kodi ma statins ndi chiyani

Gulu la ma statins ndi piritsi lomwe nthawi zambiri limafotokozedwa ndi dokotala kwa odwala omwe ali ndi cholesterol yambiri ya plasma. Chifukwa chake, akukhulupirira kuti ma statins ndi njira zabwino kwambiri zochotsekera cholesterol, kupewa matenda amtima, ischemia, ndi kuchepa kwa ubongo.

Koma kuti amvetsetse momwe amagwirira ntchito gulu lino la mankhwala, munthu ayenera kudziwa momwe mowa wa lipophilic umapangidwira, cholinga chake ndi ntchito yake m'thupi. Cholesterol imapangidwa ndi 85% m'thupi payokha, ndipo 15% yotsala yokha imabwera ndi chakudya.

Organic phatikizidwe zimachitika m'njira zambiri:

• biosynthesis yamahomoni, kuphatikiza maliseche,
• kuteteza maselo ofiira kuti asawononge poizoni ndi ma hemolytic poisons,
• malamulo a mtima kukhathamiritsa ndi cell zimagwira,
• kupanga bile ndi vitamini D,
• kukhalabe ndi mphamvu yama cell mthupi lonse.

Kuti mupeze cholesterol yathunthu kuzinthu zonse komanso ziwalo zamkati, mapuloteni apadera amapangidwa - lipoproteins. Ngati kuchuluka kwa mowa wa lipophilic mthupi kuchulukitsidwa, muyenera kuchitapo kanthu kuti muchepetse.

M'magawo oyamba a kusintha kwa atherosselotic, ichi ndi chakudya, masewera, kukana zosokoneza bongo, kupumula koyenera ndikukhalanso ndi mpweya wabwino. Pokhapokha pakuchitika izi, madotolo amatumiza mankhwala a gulu la statin. Zimalepheretsa kupanga ma enzyme omwe amapanga lipoprotein.

Zotsatira zake, kuchuluka kwa mafuta m'thupi omwe amalowa mkati mwa minofu amachepa, ndipo kuchuluka kwa mayendedwe obwerera kumawonjezeka. Pokhudzana ndi kumwa mankhwala a gulu la statin, kuchuluka kwa mowa wa lipophilic m'thupi kumachepa, pomwe mafuta ndi zolembera zomwe zimapezeka m'matumba a capillaries zimagawika.

Ubwino ndi kuvulaza kwa mankhwala

Ma Statin si gulu la mankhwala omwe mungadzipatse nokha, chifukwa ali ndi zotsatira zoyipa zambiri ngati atagwiritsidwa ntchito molakwika. Ndi kachulukidwe kakang'ono ka cholesterol, mutha kuthana nako kunyumba ndi zakudya komanso masewera olimbitsa thupi. Koma pamaso pa chiwonetsero chachikulu, madokotala nthawi zambiri amalimbikitsa kutenga ma statins.

Ndi kuperewera kwa mankhwala osagwiritsa ntchito mankhwala, gulu la mankhwalawa silingathe kuchepetsa cholesterol yathunthu, komanso kupewa matenda owopsa a mtima. Ubwino wama statins:

• chiopsezo chochepa chodwala matenda a mtima,
• kupewa matenda a m'magazi,
• Mpumulo wa zizindikiro za atherosulinosis ya mtima ndi kupewa zovuta zamatendawo mtsogolo,
• kukhazikika kwa mtima ntchito mu angina pectoris ndi ischemia,
• kuthetsa matenda a shuga,
• Kuchepa kwa odwala onenepa kwambiri,
• Kuchotsa kwa zotupa za makoma a capillaries,
• Kuchepetsa magazi ndi kupewa thrombosis,
• kuchuluka kwa kupendekera kwa ma capillaries,
• kukhazikitsa njira zosinthira.

Statin amamuthandizira kuti azithandiza kuchira pambuyo pa kugunda kwa mtima, matenda a m'matumbo, embolism, komanso pambuyo pa opaleshoni (stenting, coronary artery bypass grafting, angioplasty). Pali ma statins omwe amapangidwa kuti achepetse cholesterol yamagazi, ndi zovuta, choyambirira ndikukhazikitsa zotsatira zoyipa.

Ndi kuchepa kwa kuchuluka kwa lipoproteins opangidwa ndi thupi, kupanga kwa coenzyme Q10 kumachepera. Izi zimapangidwa kuti zipereke minofu ndi minyewa ya ubongo ndi nkhokwe zamphamvu, ndipo ndikusowa kwa coenzyme, munthu amayamba kuvutika ndi ululu wa minofu, kufooka, kudumpha mopanikizika, kusowa chidwi komanso kutopa.

Pogwiritsa ntchito ma statins, kuwonongeka kwa minofu minofu kumatha kuyamba, mwanjira ya sayansi - rhabdomyolysis. Zotsatira zoyipa zimatha kuchitika popanda kugwiritsa ntchito molakwika mapiritsi amtundu uliwonse wa thupi.

Ma statins abwino ochepetsa cholesterol yamagazi

Mapiritsi oyamba a cholesterol anapangidwa pamaziko a zinthu zachilengedwe ndipo amatchedwa lovastatin. Kuphatikiza apo, mankhwala onse opangidwa anali opangidwa.

Iwo amene amakhulupirira kuti mankhwala opangidwa mwachilengedwe ndi otetezeka ndipo amakhala bwino akulakwitsa, chifukwa ma fanizo opangidwa amakhala ndi zovuta zochepa, amakhala osavuta kulolera ndi thupi. M'badwo woyamba wa statins umaphatikizapo osati lovastatins, komanso pravastatins ndi simvastatins.

Mapiritsi a Lovastatin

Woimira wamkulu wa gululi ndi mankhwala Lovastatin. Imapezeka mu mawonekedwe a mapiritsi a 20 kapena 40 mg, ali m'gulu lamankhwala ochepetsa lipid. Kapangidwe kake ndikuphwanya gawo loyambirira la cholesterol synthesis mu chiwindi (kupangidwa kwa mevalonic acid).

Imatsika plasma voliyumu yotsika kwambiri komanso yotsika kwambiri ya lipoprotein, triglycerides ndipo imachulukitsa kuchuluka kwa lipoproteins yapamwamba. Kutalika kwa gawo limodzi la mapiritsi olumikizidwa ndi lovastatin ndi maola 24, motero, mankhwalawa amayenera kumwa kamodzi patsiku, makamaka madzulo.

Zisonyezero zogwiritsidwa ntchito:

• hypercholesterolemia yoyamba komanso yabanja yokhala ndi vuto la kudya,
• Kuchepetsa kukula kwa zotupa zamatenda am'mimba,
• kupewa matenda a mtima ndi stroko odwala omwe ali ndi ischemia, komanso mbali yovuta ya mankhwala okhala ndi mafuta a lipophilic overestimated.
• kupewa chachikulu matenda a mtima.

Kukonzekera kochokera pa lovastatin:

• Liprox,
• Chikhululu
• Lovasterol
• Mevacor
• Holetar,
• Apextatin,
• Medostatin,
• Rovacor
• Lovacor.

Mndandanda wazotsatira zimaphatikizira matupi awo sagwirizana (ndi kuchuluka kwa chidwi ndi lovastatin), jaundice, kuchuluka kwa hepatic transaminases, myopathy, rhabdomyolysis, interstitial mapapu, chizungulire, kupweteka mutu, kusowa tulo, ndi neurosis. Mndandanda wathunthu wazotsatira zimalengezedwa m'mayendedwe ogwiritsira ntchito mankhwalawa.

Kukonzekera kwa Fluvastatin

Gulu la mankhwalawa ndi la gulu lachiwiri la ma statins, awa ndi mankhwala othandiza komanso otetezeka omwe amachepetsa cholesterol, yomwe akatswiri amalemba ngakhale ali mwana, kuyambira zaka 10. Zisonyezero zosonyeza mapiritsi atengera fluvastatin:

• dyslipidemia,
• kupewa mavuto a ischemic matenda a mtima,
• coronary atherosulinosis,
• hypercholesterolemia,
• Monga njira yovuta yothandizira, popewa zovuta mu nthawi yothandizira mukakhala ndi mtima ndi mitsempha yamagazi.

Kukonzekera kwa Fluvastatin kumaphatikizapo mchere wa sodium pazomwe zimapangidwira, chifukwa chomwe ndende ya lipophilic imatsika mofulumira kwambiri. Asanayambe chithandizo, wodwalayo ayenera kutsatira zakudya kwa masabata 3-4, monga nthawi yomwe amalandila chithandizo. Mlingo woyambirira wa fluvastatin nthawi zambiri amakhala 20 mpaka 40 mg kamodzi tsiku lililonse madzulo.

Kukonzekera kokhala ndi fluvastatin:

Zotsatira zakugwiritsira ntchito mankhwalawa zimadziwika pambuyo pa mwezi, pambuyo pake wodwalayo amayenera kubweretsanso mayeso kuti adziwe ngati mlingo woyambayo ndi wokwanira kapena ngati ukufunikira kuchuluka. Nthawi zambiri munthawi yonse ya mankhwalawa amayenera kuwunika kuchuluka kwa cholesterol m'magazi ndikusintha Mlingo ngati pakufunika.

Mapiritsi a Atorvastatin

Mankhwala omwe ali mgululi ali otsika mtengo, koma ogwira mtima kutsitsa cholesterol yamagazi ndikuwongolera magwiridwe antchito amtima wonse, ali mu m'badwo wachitatu wama statins. Komanso, mankhwala omwe ali ndi gawo la atorvastatin amawoneka kuti ndi otetezeka, amathandiza kupewa zovuta za odwala omwe ali ndi matenda osokoneza bongo komanso matenda a mtima, kuphatikizapo mtima ischemia.

Zisonyezero zogwiritsidwa ntchito:

• kupangidwiratu kwamatsenga a mtima ndi mitsempha yamagazi,
• dyslipidemia
• Hypercholesterolemia, kuphatikizapo mawonekedwe ofooka,
• atherosulinosis monga chowonjezera chachikulu chothandizira kuchiritsa matenda.

Mankhwala a Atorvastatin amayeneranso kumwa kamodzi patsiku, mlingo woyambirira umadalira kuopsa kwa hypercholesterolemia ndipo amatsimikiza ndi dokotala (kuyambira 5 mpaka 80 mg). Mndandanda wazotsatira zoyipa ndi zotsutsana ndizofanana ndi ma statins ena.

Mapiritsi okhala ndi atorvastatin monga yogwira ntchito:

Zili bwino kumwa mapiritsi a mankhwala, simungadziwe nokha. Asanayambe chithandizo, katswiri amasanthula mbiri ya wodwalayo, amamuwuza kukayezetsa ndi kuyesedwa ma labotale. Kuphatikiza apo, wodwala aliyense amatha kuyankha mosiyanasiyana pakapangidwe kamapiritsi kapena kusamva bwino kwa chinthu chomwe chikugwira.

Mankhwala okhala ndi Simvastatin

Mankhwalawa amawonedwa kuti ndi otchipa komanso ogwira mtima kutsitsa cholesterol yayikulu. Ntchito yogwira simvastatin imatengedwa mwachangu ndi minyewa ya chiwindi, ndipo zotsatira zowoneka zimadziwika kale masabata 4-5 atayamba maphunziro.

Zisonyezero zogwiritsa ntchito simvastatin:

• Odwala omwe ali ndi vuto lalikulu la matenda oopsa a shuga, ischemia, matenda a zotumphukira ndi ziwalo za mtima. Amatinso kupewa kuti asawononge matenda a mtima osagwera, stroke, ischemia yayikulu,
• Hyperlipidemia yoyambira ndi sekondale, kuphatikiza banja heterozygous - posapeza phindu la chakudya choletsa mafuta komanso kuthandizira pakulimbitsa thupi,
• hypertriglyceridemia - monga njira yowonjezerapo yochepetsa magazi m'thupi komanso kuwonjezera kuchuluka kwa zotupa za lipoproteins,
• Kuthandiza kwa odwala musanachite opareshoni - makina amitsempha yamagazi ndi kumalumikiza, kukonzanso.

Mlingo woyambirira wa 5 mg wa simvastatin umalimbikitsidwa kwa odwala osakhala pachiwopsezo cha mtima ndi mitsempha yamagazi komanso kuwonjezereka kwa mafuta a cholesterol osagwiritsika ntchito pamene mankhwalawo amadya. Mlingo wapamwamba wa tsiku ndi tsiku wa 80 mg umaperekedwa kwa odwala omwe ali ndi ischemia, angina pectoris, atherosulinosis yapamwamba. Nthawi yomweyo, kuwunika kwa odwala koteroko ndikofunikira.

Mndandanda wa mankhwala opangidwa ndi simvastatin:

Monga ma statins ena, mukamagwiritsa ntchito mankhwala okhala ndi simvastatin pamakhala chiopsezo chotenga myopathy (kupweteka kwa minofu, kufooka komanso kuwonongeka konsekonse), komanso rhabdomyolysis (chiwonongeko chotheratu cha minofu minofu). Ndikofunikira kuyesedwa musanayambe maphunziro ndikuwonetsetsa kuti palibe zotsutsana.

Pravastatin monga chogwira ntchito

Gawo lomwe limagwira ntchito ya pravastatin ndi gawo loyamba la mankhwala ochepetsa lipid, amadziwika kuti ndi chinthu chotetezeka koma chothandiza kutsitsa cholesterol yamagazi. Pravastatin ili ndi mankhwala otsatirawa: Pravastatin, Lipostat, Praspwering.

Mapiritsi okhala ndi pravastatin amalembedwa kwa odwala omwe ali ndi kuchuluka kwambiri kwa otsika komanso otsika kwambiri a lipoprotein m'magazi, komanso ndi hypercholesterolemia yoyamba, pamene njira zina zosagwiritsa ntchito mankhwala sizikugwira ntchito. Ngati wodwalayo sanangokweza mowa wa lipophilic, komanso triglycerides, akatswiri amawona kuti ndizoyenera kupereka pravastatin ngati cholesterol yayikulu ndi matenda otsogolera.

Munthawi yonse ya chithandizo (masabata osachepera 4-8), kuwunika kusintha kwa cholesterol yamagazi mumphamvu akuwonetsedwa. Mlingo woyambirira ndi 1040 mg, koma ndi kuchuluka kwa mowa wa lipophilic (pamtunda wa 300 mg / dl), 40 mg ndi yoyenera. Mutha kugawa m'njira zingapo.

Zotsatira zoyipa ndizofanana ndi ma statins ambiri. Awa ndi zotupa pakhungu ndi kusalolera kwa magawo amtundu wa mapiritsi, kukula kwa zotupa zam'matumbo (myopathy), chizungulire, kukomoka, kupweteka kwa epigastric, chidwi, chizolowezi,

Mndandanda wa contraindication woyembekezera, mkaka wa m`mawere, ana osakwana zaka 18. Pravastatin amagwiritsidwa ntchito mosamala pochiza odwala omwe ali ndi vuto la chiwindi chachikulu komanso anthu omwe adamwa mowa kale.

M'badwo waposachedwa wa statins

The yogwira zinthu rosuvastatin ndi pitavastatin ali m'gulu la statins a m'badwo wotsiriza. Izi zikuthandizira mapiritsi ndi zomwe zachitika posachedwa zamankhwala, chifukwa chake zimakhala ndi zovuta zochepa komanso zabwino zambiri:

• kuyambika kwakanthawi kowoneka - monga masiku 7 mpaka 14,
• kuthekera kwa kupereka mankhwala muyezo wochepa, womwe ungayambitse kuchepa kwa cholesterol yamagazi,
• kotalika
• kulolerana kwabwino ndi thupi komwe kumakhala ndi zovuta zina,
• kusowa kwa contraindication pa munthawi yomweyo mankhwala a statins ndi mtima mankhwala,
• kusakhalapo kwa vuto la glucose metabolism.

Akatswiri amalimbikitsa m'badwo waposachedwa kwambiri wa ma statins ngati okwera mtengo, koma mankhwala abwino kwambiri ochizira matenda a dyslipidemia, atherosulinosis (kuphatikizapo pang'onopang'ono ndikupita patsogolo m'njira zovuta).

Rosuvastatin ndi pitavastatin amatha kulembedwa kwa odwala omwe ali ndi matenda osokoneza bongo, omwe amatsogolera kumatenda amitsempha yamagazi, omwe ali ndi hypercholesterolemia nthawi iliyonse, komanso akamachira opaleshoni ya mtima, kugunda kwa mtima ndi sitiroko. Mankhwala okhala ndi rosuvastatin:

Mbadwo waposachedwa wa mapiritsi ochepetsa a lipid unayambitsidwa ndi makampani opanga ma pharmacological osati kale kwambiri, koma apeza kale mbiri ngati mankhwala othandiza komanso otetezeka. Poyerekeza ndi mankhwala ena a classin, ali ndi chochita mwachangu kwambiri popanda zovuta zaumoyo.

Mankhwala olowa m'gulu la mafrati amagwiritsidwanso ntchito nthawi zambiri kuti muchepetse cholesterol yambiri, komanso moyenera, kuchepetsa kuchuluka kwa mowa "wamavuto" a lipophilic m'magazi ndikuwonjezera kuchuluka kwa "zothandiza". Fibates imachepetsa kupita patsogolo kwa atherosulinosis, kuphatikizapo odwala omwe ali ndi matenda a mtima. Poyerekeza zakumwedwa kwa gululi, kuchuluka kwaimfa pakati pa oimira odwala omwe ali ndi matenda amtima kumachepa.

Mapiritsi agawika mibadwo ingapo:

1. Clofibrate - mankhwalawa tsopano samadziwika ndi madokotala atalandira chidziwitso kuti amachititsa cholangiocarcinoma komanso kukula kwa zotupa m'mimba m'mimba (thirakiti la m'mimba).
2. Gemfibrozil ndi bezafibrat.
3. Fenofibrate ndi Ciprofibrate.

Fifates ndi agonists a subclass of nyukiliya receptors omwe amayang'anira lipoprotein metabolism, kupanga ma apoprotein ndi njira zina. Chifukwa chotenga imodzi ya mankhwalawa, kuchuluka kwa ma lipoprotein okwera kwambiri m'magazi kumawonjezeka, kuchuluka kwa triglycerides kumatsika ndi 30-50%, ndi lipoproteins yotsika ndi 10-20%.

Ngati mulingo wa triglycerides mwa odwala ndiwoposa 5.6 mmol / l, kuyikidwa kwa mafupa kwa iye ndizovomerezeka kuti apewe kukula kwa chifuwa chachikulu cha kapamba. Gwiritsani Ntchito Mlingo:

• Gemfibrozil - 600 mg kawiri pa tsiku,
• Besafibrate - 200 mg katatu patsiku,
• Ciprofibrate - 100 mg 1-2 patsiku,
• Fenofibrate - 145-200 mg kamodzi patsiku.

Mwachilengedwe, mankhwalawa a gulu la fibrate amaloledwa bwino ndipo amatha kutsitsa cholesterol yoyipa m'magazi. Zotsatira zoyipa zimaphatikizira kupweteka kwam'mimba, kusokonezeka kwa chopondapo, kutulutsa magazi, kugona tulo, zotupa za khungu, komanso chizungulire.

Fibates sinafotokozedwe kwa odwala omwe ali ndi cholelithiasis, popeza amonjezera lipogenicity ya bile pogwiritsa ntchito nthawi yayitali. Ndi nthawi yomweyo kutumikirana ndi ma statins, kuyang'anira magazi, mkodzo ndi ntchito ya chiwindi ndi ntchito.

Mwachidule

Kusankhidwa kwa mankhwala oyenera a cholesterol yayikulu ndikofunikira kwa dokotala. Katswiri yekha ndi amene amatha kuyesa wodwala, kumusankhira mapiritsi malinga ndi zomwe akuwonetsa ndikuzindikira zotsutsana zomwe zilipo. Posankha mankhwala ndizosatheka kungoganizira mtengo wake.

Kutsika mtengo sikungakhale kwapamwamba nthawi zonse, ngakhale kuti mtengo wokwera sutsimikizire kuti zotsatira zake ndizachangu komanso zachangu. Ndikwabwino kutsatira tanthauzo la golide, kutsatira malangizo a dokotala ndikumatenga mapiritsi mwamphamvu monga mwa chiwembu. Kenako mankhwala omwe akupangidwawo amakhala opindulitsa ndipo sadzakhala ndi zotsatilaza thupi.

Muyezo wamapiritsi abwino kwambiri a cholesterol

Ma statins amakono kuti muchepetse cholesterol

Mibadwo ingapo ya ma statins panoadziwika. Ndipo, ngakhale magulu angapo a mankhwala amachepetsa cholesterol, ndi ma statins omwe amatsogolera kuchuluka kwa mankhwala padziko lonse lapansi. Onsewa amachita monga makina ofanana, amalepheretsa puloteni ina yotchedwa HMG-CoA reductase. Imagwira ntchito m'chiwindi, ndipo imakhudzidwa ndi kapangidwe ka cholesterol. Choyamba, taganizirani za mankhwala amakono a cholesterol - omaliza, mbadwo wachinayi.

Rosuvastatin - Crestor (Rosucard, Rosulip, Tevastor)

Mankhwala Krestor akuwonetsedwa kwa odwala onse kuti akwaniritse zomwe amayang'anira cholesterol, omwe ali pachiwopsezo chotenga ngozi za mtima. Odwala oterewa amaphatikizapo anthu omwe ali ndi matenda oopsa, matenda a shuga, matenda a mtima. Pali zochitika zina: musanamwe mankhwalawa, wodwalayo ayenera kutsimikizira kuti amatha kusintha zakudya zake ndikutsatira zakudya zomwe zimachepetsa mafuta m'thupi. Palibe nzeru kumwa mankhwala ngati wodwala sakutsatira zakudya ndipo akudya magwero ambiri a cholesterol ndi chakudya. Chifukwa chake, mankhwala onse ochepetsa cholesterol amafunika chakudya.

Mlingo wofanana wa Crestor umachokera pa 5 mpaka 10 mg pa tsiku, ndipo mlingo woyambirira umadalira ndende yoyamba ya cholesterol. Mutha kuonjezera mlingo pokhapokha mwezi umodzi. Pazipita tsiku lililonse 40 mg tsiku. Osatafuna piritsi, ndipo mutha kumamwa nthawi ina iliyonse masana osadya.

Kampani yaku Britain ya Astra Zeneca imatulutsa Krestor, ndipo phukusi lokhala ndi mulingo wocheperako (piritsi ya 5 mg) lidzagulitsa ma ruble 1835 pamapiritsi 28. Uwu ndi mtengo wotsika kwambiri wa maphunziro mwezi uliwonse.Popeza kuti nthawi zambiri pamawonjezera pang'onopang'ono muyezo wa mankhwalawo umafunikira, ziwerengero zina zitha kutchulidwanso monga chitsanzo. Phukusi lomweli limakhala lokwera kokwana kanayi, mu 0,02 g lidzagula ma ruble 3925, linapangidwanso mwezi umodzi wovomerezeka. Pali zosankha zotsika mtengo. Chifukwa chake, phukusi la Rosart (Actavis) limatenga ma ruble 535, mapiritsi 28 omwewo a 5 mg aliyense.

Ubwino ndi zoyipa

Ubwino wa mankhwalawa ndiwambiri ntchito ndikuwatsimikizira ogwira ntchito. Okalamba, palibe kusintha kwa mlingo komwe kumafunikira, koma nthawi zambiri mfundo imeneyi iyenera kukumbukiridwa popereka mankhwala ambiri kwa okalamba. Komanso, simungasinthe mlingo wa mawonekedwe ofatsa a kulephera kwa aimpso.

Ngakhale Krestor ndiwothandiza kwambiri pamaphunziro ambiri, ali ndi zotsutsana. Umu ndi momwe nthawi yomweyo amathandizira ndi cyclosporine, kutenga pakati komanso nthawi yoyamwitsa, kupezeka kwa myopathies osiyanasiyana, komanso kumwa mowa. Mosamala, mutha kugwiritsa ntchito Krestor ndi chithokomiro chochepetsedwa, komanso ndi zovuta zina za endocrine komanso khunyu. Komabe, ndi zolephera zonse, Crestor ndi imodzi mwazinthu zabwino kwambiri komanso zamakono zamankhwala zochepetsera ngozi ya kufa mwadzidzidzi ndi masoka amitsempha.

Atorvastatin - Liprimar (Tulip, Torvacard, Atoris)

Liprimar ndi piritsi yothandiza kwambiri ya cholesterol, koma siili achinayi, koma a m'badwo wachitatu, wama statins. Zomwe zimagwira ndi atorvastatin. Kusiyanitsa kwakukulu pakati pa m'badwo wachinayi ndi wachitatu wama statins ndikuti mankhwala am'badwo wachitatu amangogwira bwino ntchito ndikuchepetsa kuchuluka kwa cholesterol "yoyipa", koma mankhwala azaka za 4, monga Krestor tafotokozazi, amathandizanso kuchuluka kwa "zabwino" m'magazi cholesterol. Koma Liprimar ndi mankhwala apamwamba komanso abwino kwambiri.

Imapezeka m'miyeso inayi: 10, 20, 40 ndi 80 mg. Amawonetsedwa kuti agwiritsidwe ntchito ndi cholesterol yoyipa "yoipa" - yokhala ndi hypercholesterolemia ya mitundu yosiyanasiyana, popewa myocardial infarction komanso matenda amtima wamtima mwa odwala omwe ali pachiwopsezo chachikulu, ndikuganiza izi kupewa komanso koyamba.

Liprimar imagwiritsidwa ntchito, ngati Krestor, kamodzi patsiku, nthawi iliyonse komanso mosasamala zakudya. Mlingo umatha kusiyanasiyana: kuchokera pa 10 mpaka 80 mg, ndi mlingo waukulu wa 80 mg tsiku lililonse. Nthawi zambiri, mankhwalawa amayamba ndi mlingo wochepa wa 10 mg patsiku, ndikuwonjezera pang'onopang'ono komanso pokhapokha malinga ndi dokotala. Liprimar ndi yotsika mtengo kuposa Krestor. Phukusi la mapiritsi 30, ndi mulingo wochepa wa 10 mg, wowerengeka maphunziro apamwezi, angapezeke m'masitolo kuyambira 350 rubles, ndipo mtengo wamba ndi ma ruble 717 pa phukusi lililonse. Liprimar amapangidwa ndi kampani yodziwika bwino ya mankhwala Pfizer.

Pali mitundu ingapo yotsika mtengo kwambiri ya Liprimar, kuphatikizapo atorvastatin. Chifukwa chake, ndendende phukusi lomwelo, lopangidwa ndi Irbit Chemical Farm lokha, pa avareji, ma ruble 135. kwa ma CD, koma ngati angafune, imapezeka m'masitolo ogulitsa pamtengo wotsika mtengo kuposa ma ruble 60.

Fluvastatin - Leskol Forte

Leskol forte ndi mankhwala othandiza kwambiri kuchepetsa mafuta m'thupi. Amawonetsedwa kwa odwala omwe ali ndi matenda a mtima, kuti apewe kulowetsedwa koyambira komanso kwachiwiri kwa matenda osokoneza bongo, okhala ndi cholesterol yoyipa, kuphatikizapo omwe amaphatikizidwa ndi zochitika zapachibale za hypercholesterolemia. Leskol ikhoza kugwiritsidwa ntchito ngati monotherapy, ndiko kuti, kuwonjezera pamenepo, palibe mankhwala omwe amafunikiranso.

Piritsi limodzi lili ndi 80 mg ya fluvastatin, ndipo mankhwalawa amamasulidwa pang'onopang'ono piritsi ili, lomwe limakupatsani mwayi wopanga ndende imodzi m'magazi am'magazi popanda kukayika usiku, womwe umafotokozera mtengo wake. Kuchuluka kwake kwa nthawi yake kumachitika mu mwezi umodzi, ndiye kuti mutha kubwereza kuchuluka kwa mankhwala ndikuwasintha. Asanayambe chithandizo, wodwalayo ayenera kukhala pachakudya chotsitsa cholesterol, ndipo zakudya izi ziyenera kutsatiridwa munthawi yonse ya chithandizo. Mankhwalawa amapangidwa ndi kampani yopanga mankhwala a Novartis, ndipo mtengo wa mapiritsi 28, wopangidwa mwezi umodzi, pafupifupi ruble 2800.

Mankhwala abwino kwambiri a magulu ena kuti muchepetse cholesterol

Statin adayesedwa ndikuwunikiridwa padera, monga momwe amafunidwira nthawi zambiri. Koma kupatula ma statins, pali magulu ena a mankhwala omwe amachepetsa kuchuluka kwa cholesterol yosafunikira m'madzi a m'magazi. Awa ndi nicotinic acid, ma resion a ion-exchange monga cholestyramine, zotumphukira za fibroic acid, zomwe zimaphatikizapo clofibrate. Ganizirani ena mwa mankhwala omwe nthawi zambiri amaikidwa ndi madokotala pochiza hypercholesterolemia mwa odwala omwe ali ndi chiopsezo cha mtima.

Ezetrol (ezetemib)

Ezetrol ndi mankhwala omwe amachepetsa cholesterol "yoyipa" m'madzi a m'magazi ndi njira ina. Sizikhudza ma enzymes a chiwindi, koma zimalepheretsa mayamwidwe a cholesterol ku chakudya m'matumbo. Chifukwa chake, m'chiwindi, malo ogulitsira cholesterol amachepera pang'onopang'ono pambuyo pokhazikitsidwa kwa Ezetrol, kenako ndende yake imatsikira m'magazi. Mankhwalawa akuwonetsedwa pochiza matenda a atherosulinosis, hypercholesterolemia, ndipo angagwiritsidwe ntchito palokha popanda kuphatikizidwa ndi ma statins oyang'aniridwa ndi dokotala. Koma chisonyezo chachikulu ndi hypercholesterolemia, yomwe imabadwa mwachibadwa ndipo imadziwonekera pazochitika zosiyanasiyana zapabanja.

Ezetrol imayikidwa nthawi iliyonse masana, mosasamala chakudya. Mlingo woyambirira wa Ezetrol ndi 10 mg kamodzi tsiku lililonse. Mtengo wa phukusi limodzi la mapiritsi 28, omwe amapangidwira maphunziro a pamwezi, ndi ma ruble 2,000, ndipo Ezetrol amapangidwa ndi kampani yodziwika bwino ya mankhwala Schering-Plow. Mitundu yambiri ya mankhwalawa sichinadziwikebe.

Lipantil (fenofibrate)

Fenofibrate imachokera ku fibroic acid, ndikuchepetsa kuchuluka kwa ma triglycerides ndi otsika kwambiri lipoproteins m'magazi, omwe, pamapeto pake, amasinthidwa kukhala cholesterol "yoyipa". Mankhwalawa amapezeka m'mapiritsi, 200 mg ya fenofibrate mu kapisozi iliyonse. Iyi ndi njira yolimbikitsira kagayidwe ka triglycerides. Chifukwa chogwiritsa ntchito, kapangidwe ka mafuta acids amasokonezeka ndipo kuchuluka kwa mafuta m'thupi kumachepa. Lipantil imathandizanso kuthamanga kwa magazi, ndipo imachepetsa pang'ono kuchuluka kwa shuga m'madzi a m'magazi, kotero amatha kuikidwa mu odwala omwe ali ndi matenda ashuga.

Kafukufuku akuwonetsa kuti Lipantil amatsitsa cholesterol yokwanira ndi 25%, ndipo akuwonetsedwa mu chithandizo chovuta cha hypercholesterolemia, chomwe sichingasinthidwe ndi zakudya. Lipantil imayikidwa ndi chakudya, kapisozi imodzi patsiku. Kutalika kwa maphunzirowa kumatsimikiziridwa ndi adokotala. Kampani yaku France Ripharm imatulutsa Lipantil, ndipo phukusi la makapu 30, lopangidwira maphunziro a pamwezi, limatengera, pafupifupi, ma ruble 1000.

Pomaliza

Pomaliza, chinthu chimodzi chofunikira, koma chosavuta kunena. Makampani amakono azachipatala amapanga mitundu yambiri ya mankhwala okwera mtengo komanso otsika mtengo kuti achepetse cholesterol, kuwatengera, malinga ndi zotsatira za kafukufuku wambiri, kumawonjezera kuchuluka kwa moyo komanso kumachepetsa chiopsezo cha masoka a mtima. Koma m'malo onsewo, mankhwalawa amayenera kugwiritsidwa ntchito, ndikofunikira kukonzekera, ndipo kukonzekera kwa wodwalayo kumachepetsedwa kusintha kwa moyo, kusiya zizolowezi zoyipa, ndipo koposa zonse, kutsatira zakudya zamafuta ochepa.

Izi ziyenera kukumbukiridwa kwa aliyense amene akuganiza kuti kumwa mapiritsi amathanso kudya. Simungasinthe chakudya ndi mapiritsi, ndikuchepetsa chiopsezo cha kufa ndi kuchuluka kwa chiyembekezo chamadera amoyo kumawonekera pokhapokha ngati wodwala samangomwa mankhwala, komanso mwakufuna kwanu.

Izi ziyenera kukumbukiridwa, ndipo simuyenera kuwononga ndalama pachabe. Pokhapokha ngati wodwala akhala akudya pafupifupi milungu itatu kapena mwezi, ndipo alibe kusintha kwa mafuta a kolesterol, ndikofunikira kulumikiza mankhwala. Ngati zakudya zibala zipatso, muyenera kupitiriza mpaka mafuta atasiya kuchepa. Ndipo ngati sakwaniritsa zomwe akufuna kuchita pachakudyacho, ndiye pokhapokha ndikofunikira kulumikiza mankhwalawo omwe akuphatikizidwa muyezo.

Yang'anani! Kuwona kumeneku ndikogwirizana, sikukutsatsa ndipo sikuwonetsa ngati kugula. Musanagule, muyenera kufunsa katswiri.