Insulin Lantus (Glargine): Dziwani zonse zomwe mukufuna. Pansipa mupeza lolemba m'chinenerochi. Werengani kuchuluka kwa magawo omwe muyenera kulowa ndi momwe, muwerengere mankhwalawa, momwe mungagwiritsire ntchito cholembera cha Lantus Solostar. Mvetsetsani nthawi yayitali jekeseni wa mankhwalawa atayamba kugwira ntchito, omwe insulin ndiyabwino: Lantus, Levemir kapena Tujeo. Ndemanga zambiri za odwala omwe ali ndi matenda a shuga 2 ndi 1 amaperekedwa.

Glargin ndi timadzi tambiri tomwe timapanga kwa nthawi yayitali ndi kampani yotchuka yapadziko lonse Sanofi-Aventis. Mwina iyi ndiye insulin yotchuka kwambiri kwa odwala matenda ashuga achi Russia. Jakisoni wake amafunika kuthandizidwa ndi njira zamankhwala zomwe zimakulolani kuti mukhale ndi shuga 3.9-5,5 mmol / l khola maola 24 patsiku, monga mwa anthu athanzi. Dongosolo lomwe lakhala ndi matenda ashuga kwa zaka zopitilira 70 limalola akuluakulu ndi ana omwe ali ndi matenda ashuga kudziteteza ku zovuta zowopsa.

Werengani mayankho a mafunso:

Long insulin Lantus: nkhani yatsatanetsatane

Dziwani kuti insulin Lantus yowonongeka imawoneka yowoneka bwino. Mwa mawonekedwe a mankhwalawa, ndizosatheka kudziwa mtundu wake. Simuyenera kugula insulin ndi mankhwala okwera mtengo kuchokera m'manja mwanu, malinga ndi kulengeza kwanu. Pezani mankhwala a shuga kuchokera kuzipatala zotchuka zomwe zimatsatira malamulo osungira.

Malangizo ogwiritsira ntchito

Mukabayidwa jakisoni wa Lantus, monga mtundu wina uliwonse wa insulin, muyenera kutsatira zakudya.

Zosankha zamadyedwe kutengera ndi matendawa:

Anthu ambiri odwala matenda ashuga omwe amaba jakisoni wa insulin amawona kuti ndizosatheka kupewa matenda a hypoglycemia. M'malo mwake, imatha kusunga shuga wokhazikika ngakhale ndi matenda oopsa a autoimmune. Ndipo makamaka, ndi matenda a shuga a 2 ochepa. Palibe chifukwa chakuwonjezera kuchuluka kwa shuga m'magazi anu kuti mudzilimbitse nokha motsutsana ndi hypoglycemia yoopsa. Onerani kanema yemwe akufotokoza nkhaniyi. Phunzirani momwe mungasinthire zakudya zopatsa thanzi komanso mulingo wa insulin.

Onani pansipa kuti mumve zambiri.

Lantus ndi mankhwala ochita chiyani? Kodi ndizitali kapena zazifupi?

Lantus ndi wa insulin. Jekeseni aliyense wa mankhwalawa amachepetsa shuga m'magazi 24. Komabe, jakisoni imodzi patsiku sikokwanira. amalimbikitsa jakisoni wa insulin yayitali kawiri pa tsiku - m'mawa ndi madzulo. Amakhulupirira kuti Lantus imawonjezera chiopsezo cha khansa, ndipo ndikwabwino kusinthana ndi Levemir kuti mupewe izi. Onani vidiyoyi kuti mumve zambiri. Nthawi yomweyo, phunzirani kusungira bwino insulini kuti isawonongeke.

Anthu ena, pazifukwa zina, amafunafuna insulini yochepa yotchedwa Lantus. Mankhwala oterowo sagulitsidwa ndipo sanakhalepo.

Mutha kubaya insulini usiku komanso m'mawa, komanso kubayitsa imodzi mwamankhwala otsatirawa musanadye: Actrapid, Humalog, Apidra kapena NovoRapid. Kuphatikiza pazomwe zili pamwambazi, pali mitundu ingapo ya insulin yomwe imagwira mwachangu yomwe imamasulidwa ku Russian Federation ndi mayiko a CIS. Musayese kubwezeretsa jakisoni waifupi kapena wa insulin ya m'mimba musanadye ndi waukulu waukulu. Izi zimabweretsa kukula kwa pachimake, ndipo pambuyo pake zovuta za matenda ashuga.

Werengani za mitundu ya insulin yothamanga yomwe ingaphatikizidwe ndi Lantus:

Amakhulupirira kuti Lantus alibe chochita, koma amatsitsa shuga chimodzimodzi 18 maola. Komabe, ambiri omwe ali ndi matenda ashuga pazowunikira zawo pamapulogalamu amati akadali ndi nsonga, ngakhale ofooka.

Insulin glargine imachita bwino kuposa mankhwala ena a nthawi yayitali. Komabe, imagwira ntchito bwino kwambiri, ndipo jakisoni wake aliyense amatenga maola 42. Ngati ndalama zilola, ndiye lingalirani m'malo mwa Tresib ndi mankhwala atsopano.

Ndi zigawo zingati za Lantus zomwe zimayenera kudula komanso liti? Momwe mungawerengere mlingo?

Mulingo woyenera wa insulin yayitali, komanso ndandanda ya jakisoni, zimatengera mawonekedwe a matenda a shuga wodwala. Funso lomwe mudafunsa liyenera kuyankhidwa limodzi. Werengani nkhaniyo ”. Chitani monga kwalembedwa.

Mitundu ya mankhwala a insulin yokhazikika yopangidwa sikungapereke shuga yokhazikika ya magazi, ngakhale wodwalayo atadwala matenda ashuga. Chifukwa chake, sichikulimbikitsa kugwiritsidwa ntchito kwawo ndipo tsamba sililembapo za iwo.

Chithandizo cha matenda a shuga a insulin - komwe mungayambire:

Ndibwino kuti mukubaya Lantus: madzulo kapena m'mawa? Kodi ndizotheka kuchedwetsa jakisoni wamadzulo m'mawa?

Madzulo ndi m'mawa jakisoni wa insulin yowonjezera amafunikira pazifukwa zosiyanasiyana. Mafunso okhudzana ndi cholinga chawo komanso kusankha kwa mankhwalawa amayenera kuyankhidwa pawokha. Monga lamulo, nthawi zambiri pamakhala mavuto ndi index index yam'mawa pamimba yopanda kanthu. Kuti mubwezere mwakale, chitani jakisoni wa insulin yayitali usiku.

Ngati munthu wodwala matenda ashuga ali ndi kuchuluka kwa shuga m'magazi pamimba yopanda kanthu, sayenera kubayira Lantus usiku.

Jakisoni wam'mawa wa insulin yayitali amapangidwira kuti shuga asakhazikike masana m'mimba. Simungayese kubwezeretsa jekeseni wa mankhwala ambiri Lantus m'mawa kuyambitsa kudya kwa insulin musanadye. Ngati shuga nthawi zambiri amadumpha mukatha kudya, muyenera kugwiritsa ntchito mitundu iwiri ya insulini nthawi yomweyo - yowonjezereka komanso mwachangu. Kuti mudziwe ngati mukufunika kupaka jekeseni wautali m'mawa, muyenera kufa ndi njala tsiku limodzi ndikutsatira mphamvu ya kuchuluka kwa shuga m'magazi.

Jakisoni wamadzulo sangayimitsidwe m'mawa. Ngati mwakhazikitsa shuga m'mawa m'mimba yopanda kanthu, musayese kuzimitsa ndi mlingo waukulu wa insulin yayitali. Gwiritsani ntchito izi mwachidule kapena ultrashort.Onjezerani mlingo wa Lantus insulin usiku wotsatira. Kuti mukhale ndi shuga wabwinobwino m'mimba yopanda kanthu, muyenera kudya chakudya cham'mawa kwambiri - maola 4-5 musanagone. Kupanda kutero, jakisoni wa insulin yayitali usiku sizithandiza, ngakhale mlingo utakhala waukulu bwanji.

Mutha kupeza mosavuta pamasamba ena njira zosavuta zogwiritsira ntchito insulin Lantus kuposa omwe amaphunzitsidwa. Mwapadera, ndikulimbikitsidwa kuti mupeze jakisoni imodzi patsiku.

Komabe, mitundu yosavuta ya mankhwala a insulin sikuyenda bwino. The odwala matenda ashuga omwe amawagwiritsa ntchito amadwala pafupipafupi hypoglycemia komanso spikes mu shuga. Popita nthawi, amayamba kufupikitsa moyo kapena kusintha munthu kukhala wolumala. Kuti muthane bwino matenda a shuga a mtundu woyamba kapena a 2, muyenera kupitiriza, kuphunzira ndikuchita zomwe zalembedwamo.

Kodi mlingo waukulu wa Lantus insulin patsiku ndi uti?

Palibe mtundu wokhazikika wa tsiku ndi tsiku wa Lantus insulin. Ndikulimbikitsidwa kuichulukitsa mpaka shuga m'magazi a odwala matenda ashuga akhale owonjezereka.

M'magazini azachipatala, odwala onenepa omwe ali ndi matenda amtundu wa 2 omwe amalandila mankhwala 100-150 patsiku amafotokozedwa. Komabe, kukwera tsiku ndi tsiku mlingo wa mankhwalawo umayamba.

Mkulu wama glucose amalumpha mosalekeza, nthawi zambiri pamakhala kuukira kwa hypoglycemia. Kuti mupewe mavutowa, muyenera kuyang'anitsitsa ndikuyika jekeseni yochepa ya insulin, yomwe ikugwirizana nayo.

Mlingo woyenera wamadzulo ndi m'mawa wa Lantus insulin uyenera kusankhidwa payekhapayekha. Ndizosiyana kwambiri kutengera zaka, kulemera kwa thupi kwa wodwala komanso kuopsa kwa matenda ashuga. Ngati mukufunikira kubaya ma unit oposa 40 patsiku, ndiye kuti mukuchita zina zolakwika. Mwambiri, osati kutsatira zakudya zotsika zamoto. Kapena kuyesa kubayira jakisoni wa insulin musanadye ndikumayambiriro kwa Mlingo waukulu wa glargine wa mankhwala.

Odwala onenepa kwambiri omwe ali ndi matenda a shuga a 2 amalimbikitsidwa kwambiri kuchita masewera olimbitsa thupi. Kuchita masewera olimbitsa thupi kumawonjezera chidwi cha thupi lanu ku insulin. Izi zipangitsa kuti azitha kugawa mosiyanasiyana mankhwalawa. Funsani kuti kuyendetsa Qi ndi chiani.

Odwala ena amatha kukoka chitsulo mu masewera olimbitsa thupi kuposa kuthamanga. Zimathandizanso.

Insulin lantus ndiofananira kwake kofanana. Kufunsira matenda apadera ndi matenda osachiritsika

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Lantus . Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Lantus machitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Lantus analogues pali kupezeka kwa mawonekedwe. Gwiritsani ntchito mankhwalawa odwala matenda a shuga a odwala matenda a shuga, akulu, ana komanso pa nthawi ya bere. The zikuchokera mankhwala.

Lantus - ndi analogue ya insulin ya anthu. Kupezedwa ndi kubwezeretsanso kwa mabakiteriya a DNA amtundu wa Escherichia coli (E. coli) (tizilombo ta K12). Imakhala ndi solubility yochepa m'malo osalowerera ndale. Mu kapangidwe kamankhwala Lantus, imasungunuka kwathunthu, yomwe imatsimikiziridwa ndi chilengedwe acidic yankho la jakisoni (pH = 4). Pambuyo poyambitsa mafuta ochulukirapo, yankho, chifukwa cha acidity yake, limalowa mu mawonekedwe osakanikirana ndi mapangidwe a microprecipitates, omwe ochepa insulin glargine (chinthu chogwira kukonzekera kwa Lantus) amatulutsidwa nthawi zonse, ndikupereka chithunzi chosalala (chopanda). Kutalika kwa mankhwala.

Ma paramu omangira a insulin glargine ndi insulin ya anthu ali pafupi kwambiri.Glulin insulin imakhala ndi mphamvu yofanana ndi insulin.

Chochita chofunikira kwambiri cha insulini ndikukhazikitsidwa kwa kagayidwe ka glucose. Insulin ndi mawonekedwe ake amachepetsa shuga m'magazi ndikulimbikitsa kukoka kwa glucose pogwiritsa ntchito zotumphukira (makamaka mafupa a minofu ndi adipose minofu), komanso kuletsa mapangidwe a shuga mu chiwindi (gluconeogenesis). Insulin imalepheretsa adipocyte lipolysis ndi proteinol, pamene ikupanga kuphatikiza mapuloteni.

Kutalika kwa nthawi ya insulin glargine makamaka chifukwa cha kuchepa kwake, komwe kumapangitsa kuti mankhwalawa azigwiritsidwa ntchito kamodzi patsiku. Kukhazikika kwa pafupifupi ndi ola limodzi pambuyo pa sc makonzedwe. Kutalika kochedwa kwa maola ndi maola 24, kutalika kwake ndi maora 29. Chikhalidwe cha insulin ndi mawonekedwe ake (mwachitsanzo, insulin glargine) pakapita nthawi amatha kusiyanasiyana kwa odwala osiyanasiyana komanso kwa wodwala yemweyo.

Kutalika kwa mankhwala Lantus ndi chifukwa kukhazikitsidwa kwake mafuta oyambira.

Insulin glargine + akubwera.

Kafukufuku wofananira wa kuzungulira kwa insulin glargine ndi insulin-isophan pambuyo pokhazikika pamayendedwe a magazi mu seramu mwa anthu athanzi komanso odwala omwe ali ndi matenda osokoneza bongo amawulula kuchepa pang'onopang'ono komanso kutalikirana kwambiri, komanso kusapezeka kwa nsonga ya insulin glargine poyerekeza ndi insulin-isofan.

Ndi s / c pokonzekera mankhwalawa 1 kamodzi patsiku, khola la insulin glargine m'magazi limakwaniritsidwa patatha masiku awiri ndi atatu atatha kumwa.

Ndi mtsempha wamkati, theka la moyo wa insulin glargine ndi insulin yaumunthu imafanana.

Mwa munthu yemwe wakula mafuta osunthika, insulin glargine imakhazikika pang'ono kuchokera kumapeto kwa carboxyl (C-terminus) ya B unyolo (beta unyolo) kuti ipange 21A-Gly-insulin ndi 21A-Gly-des-30B-Thr-insulin. Mu plasma, onse insulin glargine osasinthika ndi zopangidwa ndi cleavage zilipo.

• matenda a shuga omwe amafunikira chithandizo cha insulin mwa akulu, achinyamata ndi ana opitilira zaka 6,
• shuga mellitus ofuna chithandizo cha insulin mwa akulu, achinyamata ndi ana opitilira zaka 2 (a fomu ya SoloStar).

Yankho la subcutaneous makonzedwe (3 ml makatiriji mu OptiSet ndi OptiKlik syringe zolembera).

Njira yothetsera ma subcutaneous makonzedwe (3 ml cartridgeges ku Lantus SoloStar syringe pens).

Malangizo ogwiritsa ntchito ndi chiwembu chogwiritsira ntchito

Lantus OptiSet ndi OptiKlik

Mlingo wa mankhwalawa komanso nthawi yakatsiku la kasamalidwe ake imayikidwa payekhapayekha. Lantus amatumizidwa kamodzi kamodzi patsiku, nthawi imodzi. Lantus amayenera kubayidwa m'mafuta am'mimba, phewa kapena ntchafu. Masamba obaya jekeseni amayenera kusinthana ndi mankhwala atsopano aliwonse omwe ali m'malo omwe akutsimikiziridwa kuti mankhwalawo ndi othandizira.

Mankhwalawa angagwiritsidwe ntchito onse ngati monotherapy, komanso kuphatikiza ndi mankhwala ena a hypoglycemic.

Posamutsa wodwala kuchokera ku insulin ya nthawi yayitali kapena yapakatikati yopita ku Lantus, pangafunike kukonza njira ya tsiku ndi tsiku ya basal insulin kapena kusintha kwa ofanana ndi mankhwala osokoneza bongo (Mlingo ndi mawonekedwe a makulidwe a insulin kapena malingaliro awo, komanso Mlingo wa mankhwala osokoneza bongo a hypoglycemic).

Mukasamutsa wodwala kuchokera pakulidwe ka insulin kawiri kawiri kulowa jekeseni imodzi ya Lantus, mlingo wa tsiku ndi tsiku wa basal insulin uyenera kuchepetsedwa ndi 20-30% m'milungu yoyamba yamankhwala kuti muchepetse chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri. Munthawi imeneyi, kuchepa kwa mulingo wa Lantus kuyenera kulipidwa ndi kuwonjezeka kwa Mlingo wa insulin yochepa, kenako ndikusintha kwa Mlingo wa mankhwala.

Monga ma fanizo ena a insulin yaumunthu, odwala omwe amalandira Mlingo wambiri wa mankhwala chifukwa cha kupezeka kwa ma antibodies kwa insulin ya anthu amatha kuwona kuwonjezeka kwa kuyamwa kwa insulin pamene akusintha kupita ku Lantus. Mukasinthira ku Lantus komanso milungu yoyamba itatha, kuyang'anira shuga m'magazi ndikofunikira ndipo ngati pakufunika kuthandizidwa, mupeze mankhwalawa.

Pofuna kusintha kwa kagayidwe kazinthu komanso kuwonjezereka kwa chidwi cha insulin, kuwongolera kwina kwa mankhwalawa kungakhale kofunikira. Kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwala, moyo, nthawi ya tsiku yoperekera mankhwala, kapena ngati zinthu zina zikuwoneka kuti zikuwonjezera kukonzekera kwa hypo- kapena hyperglycemia.

Mankhwala sayenera kuperekedwa. Mu / pakubweretsa njira yanthawi zonse, yomwe imapangidwira kukonzekera kwa sc, imatha kuyambitsa kukula kwa hypoglycemia.

Asanakhazikitsidwe, muyenera kuwonetsetsa kuti ma syringe alibe zotsalira zamankhwala ena.

Malamulo ogwiritsira ntchito ndikugwiritsa ntchito mankhwalawa

OptiSet asanadzaze ma syringe pensulo

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi. Ma cholembera opanda kanthu a OptiSet sanapangidwe kuti agwiritsenso ntchito ndipo akuyenera kuwonongeka.

Popewa kutenga kachilomboka, cholembera chomwe chimakhala chodzaza ndi chida chokha chogwiritsidwa ntchito ndi wodwala m'modzi yekha ndipo sichingasamutsidwe kwa munthu wina.

Kugwira cholembera cha OptiSet Syringe

Pa ntchito iliyonse yotsatira, gwiritsani ntchito singano yatsopano. Gwiritsani masingano okha oyenera cholembera cha OptiSet.

Jekeseni iliyonse isanachitike, kuyesedwa koyenera kuyenera kuchitidwa nthawi zonse.

Ngati cholembera chatsopano cha OptiSet chikugwiritsidwa ntchito, kukonzekera kuyesa kugwiritsa ntchito kuyenera kuchitika pogwiritsa ntchito magawo 8 osankhidwa ndi wopanga.

Wosankha mlingo akhoza kuzunguliridwa mbali imodzi.

Osatembenuza wokonza mlingo (kusintha kwa mlingo) mutakanikiza batani loyambira jakisoni.

Wina akapaka jakisoni kwa wodwala, ayenera kusamalidwa mwapadera kuti apewe kuvulala mwangozi ndi matenda opatsirana.

Osamagwiritsanso ntchito cholembera cha sytige ya OptiSet yowonongeka, komanso ngati vuto lakukayikira likuwoneka.

Ndikofunikira kukhala ndi cholembera cha sytige yopumira ya OptiSet ngati mutayika kapena kuwonongeka kwa omwe mumagwiritsa ntchito.

Mukachotsa chipewa mu syringe cholembera, onetsetsani zomwe zili patsamba losungirako la insulin kuti zitsimikizire kuti ili ndi insulin yoyenera. Maonekedwe a insulini ayeneranso kufufuzidwa: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, lopanda zinthu zolimba zowoneka komanso lokhazikika monga madzi. Osagwiritsa ntchito cholembera cha sytinge ya OptiSet ngati njira ya insulin ndi yopanda mitambo, yothinitsidwa kapena yokhala ndi tinthu tachilendo.

Mukachotsa kapu, samalirani mosamala ndikulowetsa singano ndi cholembera.

Kuyang'ana kukonzeka kwa cholembera kuti mugwiritse ntchito

Pamaso pa jekeseni iliyonse, ndikofunikira kuyang'ana kukonzekera kwa cholembera kuti mugwiritse ntchito.

Kwa cholembera chatsopano chatsopano komanso chosagwiritsidwa ntchito, chizindikiro cha mankhwalawa chiyenera kukhala nambala 8, monga momwe zimapangidwira kale ndi wopanga.

Ngati cholembera chikagwiritsidwa ntchito, wopereka amayenera kuzunguliridwa mpaka chizindikiritso cha mankhwalawo chikuima nambala 2. Wowunikirawo azizungulira mbali imodzi yokha.

Kokani batani loyambira kwathunthu kuti mupeze mlingo. Osazungulira wosankha wa mankhwalawo mutatha batani loyambira litulutsidwe.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa. Sungani kapu yakunja kuti mupeze singano yogwiritsidwa ntchito.

Mukugwira cholembera ndi singano yoloza m'mwamba, ikani pang'onopang'ono zitsulo za insulini ndi chala chanu kuti thovu lakumwamba lithe kulunjika ku singano.

Pambuyo pake, dinani batani loyambira njira yonse.

Ngati dontho la insulin litulutsidwa kuchokera kunsonga ya singano, cholembera cha singano ndi singano chimagwira ntchito molondola.

Ngati dontho la insulin silikuwoneka pamphepete mwa singano, muyenera kubwereza kuyeserera kwa cholembera kuti mugwiritse ntchito mpaka insulin itaonekere kumapeto kwa singano.

Mankhwala a insulin

Mlingo wa mayunitsi 2 mpaka 40 ungayikidwe mu zowonjezera za 2 mayunitsi. Ngati mlingo wopitilira mayunitsi 40 ukufunika, uyenera kutumikiridwa pobayira ziwiri kapena zingapo. Onetsetsani kuti muli ndi insulin yokwanira muyezo wanu.

Mulingo wa insulin yotsalira pachidebe cha insulin imawonetsa kuchuluka kwa insulini yotsalira mu cholembera cha sytiitet ya OptiSet. Mlingowu sungagwiritsidwe ntchito kumwa mankhwala a insulin.

Ngati piston wakuda ali kumayambiriro kwa mzere wachikuda, ndiye kuti pali magawo 40 a insulin.

Ngati pisitoni wakuda ili kumapeto kwa mzere wachikuda, ndiye kuti pali magawo 20 a insulin.

Wosankha mlingo uyenera kutembenuzidwa mpaka muvi womwenso uwonetsa mlingo womwe ungafune.

Kumwa kwa insulin

Batani loyambira jekeseni liyenera kukokedwa mpaka kumalizira kuti mudzaze cholembera.

Ziyenera kuwunikidwa ngati mulingo wofunikira uli ndi zonse. Batani loyambira limasuntha molingana ndi kuchuluka kwa insulini yomwe yatsala mu thanki ya insulin.

Yambitsani batani limakupatsani mwayi kuti muone ngati ndiwomwe udayamwa. Mukamayesedwa, batani loyambira liyenera kupitilizidwa mphamvu. Mzere womaliza wowoneka bwino pabatani wayambira kuchuluka kwa insulin yomwe yatengedwa. Pokhazikitsa batani loyambira, pamwamba pamzerewu ndiwowoneka.

Ophunzitsidwa mwapadera ayenera kufotokozera wodwalayo njirayo.

Singano imalowetsedwa pang'onopang'ono. Batani loyambira jekeseni liyenera kukanikizidwa mpaka pakufika. Kungodinanso kukusiyani pomwe batani la jekeseni litakankhidwa njira yonse. Kenako, batani loyambira jakisoni liyenera kusindikizidwa kwa masekondi 10 musanachotsere singano pakhungu. Izi zitsimikiza kukhazikitsidwa kwa mlingo wonse wa insulin.

Pakapita jakisoni aliyense, singano imayenera kuchotsedwa mu cholembera ndikuchotsa. Izi zimathandiza kupewa matenda, komanso kutayika kwa insulini, kudya kwa mpweya komanso kuthekera kwa singano. Singano sizingagwiritsenso ntchito.

Pambuyo pake, valani chipewa cha syringe cholembera.

Makatoni amayenera kugwiritsidwa ntchito limodzi ndi cholembera cha syringe ya OptiPen Pro1, komanso molingana ndi malingaliro omwe adaperekedwa ndi wopanga chipangizocho.

Malangizo ogwiritsira ntchito cholembera cha sytige ya OptiPen Pro1 okhudza kukhazikitsidwa kwa katiriji, zolumikizira singano, ndi jakisoni wa insulin ziyenera kutsatiridwa chimodzimodzi. Yenderani cartridge musanagwiritse ntchito. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe tizinthu totsimikizika tolimba. Asanakhazikitse cartridge mu syringe cholembera, cartridge iyenera kukhala pakupanda kutentha kwa maola 1-2. Musanalowetse jakisoni, chotsani thovu lakumtunda. Ndikofunikira kutsatira mosamalitsa malangizo. Makatoni opanda kanthu sagwiritsidwanso ntchito. Ngati cholembera cha sytiit ya OptiPen Pro1 chawonongeka, simuyenera kuchigwiritsa ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala posankha yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochita 100 IU / ml).

Optical Dinani Cartridge System

Pulogalamu yama cartridge ya OptiClick ndi kapu yagalasi yokhala ndi 3 ml ya insulin glargine solution, yomwe imayikidwa mu chidebe chowoneka bwino cha pulasitiki chomwe chili ndi zida za piston.

Dongosolo la cartridge la OptiClick liyenera kugwiritsidwa ntchito limodzi ndi cholembera cha sytinge ya OptiClick molingana ndi malangizo ogwiritsira ntchito omwe adabwera nawo.

Ngati cholembera cha sytiit ya OptiClick chawonongeka, chotsani ndi chatsopano.

Asanakhazikitse dongosolo la cartridge mu cholembera cha sytiit ya OptiClick, liyenera kukhala kutentha kwa firiji kwa maola 1-2. Njira yama cartridge iyenera kuyang'aniridwa isanayikidwe.Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe zinthu zophatikizika. Pamaso jakisoni, thovu la mpweya liyenera kuchotsedwa mu dongosolo lama cartridge (lofanana ndi cholembera). Makina a cartridge opanda kanthu sagwiritsidwanso ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala polemba yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochitika 100 IU / ml).

Popewa matenda, munthu m'modzi yekha ndi amene ayenera kugwiritsa ntchito cholembera.

Lantus SoloStar iyenera kuyendetsedwa mosavomerezeka kamodzi patsiku nthawi ina iliyonse, koma tsiku lililonse nthawi imodzi.

Odwala omwe ali ndi matenda a shuga 2, Lantus SoloStar angagwiritsidwe ntchito ngati monotherapy komanso kuphatikiza mankhwala ena a hypoglycemic. Cholinga cha shuga wamagazi, komanso Mlingo ndi nthawi ya makonzedwe kapena makonzedwe a hypoglycemic ayenera kutsimikizika ndikusintha payekhapayekha.

Kusintha kwa magazi kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwalayo, moyo wawo, kusintha nthawi ya makulidwe a insulin, kapena mikhalidwe ina yomwe ingalimbikitse chidwi chakukula kwa hypo- kapena hyperglycemia. Kusintha kulikonse kwa insulin kuyenera kuchitika mosamala komanso moyang'aniridwa ndi achipatala.

Lantus SoloStar si insulin yosankha yochizira matenda ashuga ketoacidosis. Pankhaniyi, kukondera kuyenera kuperekedwa / pakubweretsa insulin yochepa. Mu mankhwalawa othandizira kuphatikiza jakisoni wa basal ndi prandial insulin, 40-60% ya mlingo wa insulin tsiku lililonse wa insulin glargine nthawi zambiri amatumizidwa kuti akwaniritse zosowa za insulin.

Odwala omwe ali ndi matenda a shuga 2 amwa mankhwalawa amamwa mankhwala a hypoglycemic pakamwa, kuphatikiza mankhwalawa kumayamba ndi mlingo wa insulin glargine 10 PESCES 1 nthawi patsiku ndipo njira yotsatira yamankhwala imasinthidwa payekhapayekha.

Kusintha kuchokera ku chithandizo ndi mankhwala ena a hypoglycemic kupita ku Lantus SoloStar

Posamutsa wodwala ku njira yochiritsira yogwiritsa ntchito nthawi yayitali kapena insulini yodwala pakanthawi kogwiritsira ntchito Lantus SoloStar, zingakhale zofunikira kusintha kuchuluka kwake (kuchuluka) ndi nthawi ya makulidwe a insulin yocheperako kapena analogue yake masana kapena kusintha Mlingo wamankhwala osokoneza bongo a hypoglycemic.

Posamutsa odwala kuchokera jakisoni imodzi ya insulin-isofan patsiku kupita ku mankhwala amodzi masana, Lantus SoloStar samasintha kawirikawiri mlingo woyambirira wa insulin (i., Kuchuluka kwa Lantus SoloStar Units patsiku lofanana ndi kuchuluka kwa IN insulin isofan patsiku).

Posamutsa odwala kuti atumize insulin-isophan kawiri masana kuti apange jekeseni imodzi ya Lantus SoloStar asanagone kuti achepetse vuto la hypoglycemia usiku ndi m'mawa kwambiri, mankhwalawa a insulin glargine nthawi zambiri amachepetsedwa ndi 20% (poyerekeza ndi insulin ya tsiku ndi tsiku isophane), kenako imasinthidwa malinga ndi yankho la wodwalayo.

Lantus SoloStar sayenera kusakanikirana kapena kuchepetsedwa ndi mankhwala ena a insulin. Onetsetsani kuti ma syringe alibe zotsalira zamankhwala ena. Mukasakaniza kapena kuchepetsera, mawonekedwe a insulin glargine amatha kusintha pakapita nthawi.

Posintha kuchokera ku insulin ya anthu kupita ku mankhwala a Lantus SoloStar komanso milungu yoyambirira itatha, kuyang'aniridwa mosamala kwa kagayidwe kamwazi m'magazi) moyang'aniridwa ndi achipatala akulimbikitsidwa, ndikuwongolera mlingo wa insulin ngati pakufunika.Monga ma fanizo ena a insulin yaumunthu, izi ndizofunikira kwambiri kwa odwala omwe, chifukwa cha kupezeka kwa ma antibodies a insulin ya anthu, ayenera kugwiritsa ntchito Mlingo waukulu wa insulin ya anthu. Odwala oterowo, akamagwiritsa ntchito insulin glargine, kusintha kwakukulu poyankha kutsata insulin kumawonedwa.

Ndi bwino kagayidwe kachakudya ndi kuchuluka kwa minyewa kumva insulin, pangafunikire kusintha mlingo wa insulin.

Kusakaniza ndi kuswana

Mankhwala Lantus SoloStar sayenera kusakanikirana ndi ma insulini ena. Kusakaniza kungasinthe kuchuluka kwa nthawi / mphamvu ya mankhwala Lantus SoloStar, komanso kutsogolera ku mpweya.

Magulu apadera a odwala

Mankhwala Lantus SoloStar angagwiritsidwe ntchito mwa ana okulirapo zaka 2. Ntchito ana osaposa zaka 2 sizinaphunzire.

Kwa odwala okalamba omwe ali ndi matenda a shuga, ndikulimbikitsidwa kugwiritsa ntchito Mlingo woyambirira, kuwonjezereka kwawo pang'onopang'ono komanso kugwiritsa ntchito Mlingo wowonjezera.

Mankhwala Lantus SoloStar amaperekedwa ngati jakisoni wa sc. Mankhwala Lantus SoloStar silinapangidwe kuti likhale ndi mtsempha wowonjezera.

Kutalika kwazinthu zambiri za insulin glargine zimawonedwa pokhapokha ngati zimayambitsidwa ndi mafuta osaneneka. Mu / kumayambiriro kwa chizolowezi subcutaneous mlingo zingayambitse kwambiri hypoglycemia. Lantus SoloStar iyenera kuyambitsidwa mu mafuta ochulukitsa a m'mimba, mapewa kapena m'chiuno. Masamba a jakisoni amayenera kusinthana ndi jakisoni aliyense watsopano m'malo omwe akutsimikiziridwa kuti mupeze mankhwala. Monga momwe zimakhalira ndi mitundu ina ya insulini, kuchuluka kwa mayamwidwe, ndipo, chifukwa, zoyambira ndi nthawi yake yochitikira, zimatha kusiyanasiyana mothandizidwa ndi zochitika zolimbitsa thupi komanso kusintha kwina kwa wodwalayo.

Lantus SoloStar ndi yankho lomveka bwino, osati kuyimitsidwa. Chifukwa chake, kupumulanso musanagwiritse ntchito sikofunikira. Pakasokonekera cholembera cha Lantus SoloStar, insulin glargine imatha kuchotsedwa mu katiriji mu syringe (yoyenera insulin 100 IU / ml) ndipo jakisoni wofunikira ukhoza kupangidwa.

Malamulo ogwiritsira ntchito ndi kusamalira cholembera chodzaza ndi SoloStar

Asanayambe kugwiritsa ntchito, cholembera cha syringe chimasungidwa kutentha kwa firiji kwa maola 1-2.

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi.

Ma syringe a SoloStar opanda kanthu sayenera kugwiritsidwanso ntchito ndipo ayenera kutayidwa.

Popewa matenda, cholembera chodzaza chisanachitike chizingogwiritsidwa ntchito ndi wodwala m'modzi ndipo sayenera kusamutsidwira wina.

Musanagwiritse ntchito cholembera cha SoloStar, werengani mosamala zidziwitso pakugwiritsa ntchito.

Musanagwiritse ntchito, gwiritsani ntchito singano yatsopano ndi cholembera chonde ndikuyesa mayeso. Ma singano okhawo omwe amagwirizana ndi SoloStar ayenera kugwiritsidwa ntchito.

Malangizo apadera amayenera kuchitika popewa ngozi zokhudzana ndi kugwiritsa ntchito singano komanso mwayi wopatsira matenda.

Palibe chifukwa chomwe muyenera kugwiritsira ntchito cholembera cha SoloStar ngati chawonongeka kapena ngati mukukayikira kuti chitha kugwira ntchito moyenera.

Muyenera kukhala ndi cholembera cha syringe ya SoloStar nthawi zonse ngati mungataye kapena kuwononga cholembera cha SoloStar.

Ngati cholembera cha SoloStar sichisungidwa mufiriji, chizichotsa maola awiri jekeseni isanachitike kuti yankho lithe kutentha. Makamaka insulini yodziwika bwino imapweteka kwambiri. Cholembera cha SoloStar chogwiritsidwa ntchito chimayenera kuwonongeka.

SoloStar syringe cholembera iyenera kutetezedwa kufumbi ndi litsiro.Kunja kwa cholembera cha SoloStar kumatha kutsukidwa ndikukupukuta ndi nsalu yonyowa. Osamiza m'madzi, kutsuka ndikuphika cholembera cha SoloStar, chifukwa izi zitha kuwononga.

Cholembera cha SoloStar chimatulutsa bwino insulin ndipo ndi chida kugwiritsa ntchito. Zimafunikanso kusamala mosamala. Pewani zochitika zomwe zingawononge cholembera cha SoloStar. Ngati mukukayikira kuwonongeka kwa cholembera cha SoloStar, gwiritsani ntchito cholembera chatsopano.

Gawo 1. Kuwongolera kwa insulin

Muyenera kuyang'ana cholembera pa cholembera cha SoloStar kuti mutsimikizire kuti ili ndi insulin yoyenera. Kwa Lantus, cholembera cha syloge ya SoloStar imakhala imvi ndi batani lofiirira pobayira. Pambuyo pochotsa kapu ya cholembera, ma insulini omwe ali momwemo amawongolera: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, losakhala ndi tinthu tolimba tomwe timakhala ngati madzi.

Gawo 2. Kulumikiza singano

Ma singano okhawo omwe amagwirizana ndi cholembera cha SoloStar ndi omwe akuyenera kugwiritsidwa ntchito. Pa jakisoni wotsatira, gwiritsani ntchito singano yatsopano yosabala. Pambuyo pochotsa chipewa, singano iyenera kuyikiridwa mosamala pa cholembera.

Gawo 3. Kuchita mayeso a chitetezo

Pamaso pa jekeseni iliyonse, ndikofunikira kuyeserera chitetezo ndikuonetsetsa kuti cholembera ndi singano zimagwira bwino komanso thovu lakum air limachotsedwa.

Muyezo Mlingo wofanana magawo awiri.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa.

Ikani cholembera ndi singano kumtunda, ikani pang'onopang'ono katoni ya insulini ndi chala chanu kuti thovu lonse lakumwamba litayendetsedwe ku singano.

Kanikizani bwino batani la jakisoni.

Ngati insulini ikuwonekera pachimake pa singano, izi zikutanthauza kuti cholembera ndi singano zikugwira ntchito moyenera.

Ngati insulini siziwoneka pamphepete mwa singano, ndiye kuti gawo 3 limatha kubwerezedwanso mpaka insulini ikawonekera pamsonga pa singano.

Gawo 4. Kusankha Mafuta

Mlingo ukhoza kukhazikitsidwa ndikulondola kwa 1 unit kuyambira pa mlingo wochepa (1 unit) mpaka mlingo waukulu (80 magawo). Ngati kuli koyenera kukhazikitsa mlingo wowonjezera wamagulu a 80, jakisoni wa 2 kapena kupitilira aperekedwe.

Zenera la dosing liyenera kuwonetsa "0" ndikamaliza kuyesa kwa chitetezo. Pambuyo pake, mlingo wofunikira ukhoza kukhazikitsidwa.

Gawo 5. Mlingo

Wodwala ayenera kudziwitsidwa za njira ya jakisoni ndi katswiri wazachipatala.

Singano iyenera kuyikiridwa pansi pa khungu.

Batani la jakisoni liyenera kukanikizidwa kwathunthu. Imachitika pamalo amenewa kwa masekondi 10 mpaka singano itachotsedwa. Izi zimathandizira kuyambitsa mtundu wa insulin kwathunthu.

Gawo 6. Kuchotsa ndi kutaya singano

Mulimonsemo, singano pambuyo pa jekeseni aliyense ayenera kuchotsedwa ndikuchotsedwa. Izi zimathandizira kupewa kuipitsidwa ndi / kapena kutenga kachilomboka, kulowa mu chidebe cha insulin ndi kutulutsa insulin.

Pochotsa ndi kutaya singano, muyenera kusamala mosamala. Tsatirani njira zoyenera zotetezera pochotsa ndi singano (mwachitsanzo, njira ya dzanja limodzi) kuti muchepetse ngozi za ngozi zogwirizana ndi singano komanso kupewa matenda.

Mukachotsa singano, tsekani cholembera cha SoloStar ndi kapu.

• hypoglycemia - imayamba kumachitika pafupipafupi ngati mlingo wa insulin uposa kufunika kwake,
• kuzindikira "kutada" kapena kuwonongeka kwake,
• wodwala matenda opatsirana
• njala
• kusakhazikika
• thukuta lozizira
• tachycardia
• kuwonongeka kwamawonekedwe
• retinopathy
• lipodystrophy,
• dysgeusia,
• myalgia
• kutupa
• Matupi awo sagwirizana ndi insulin (kuphatikizapo insulin glargine) kapena magawo othandizira a mankhwalawa: khungu limakhudzanso, angioedema, bronchospasm, ochepa hypotension, mantha,
• redness, kupweteka, kuyabwa, ming'oma, kutupa kapena kutupa pamalo a jekeseni.

• zaka za ana mpaka zaka 6 za Lantus OptiSet ndi OptiKlik (pakadali pano palibe zambiri zakugwiritsa ntchito)
• zaka za ana mpaka zaka 2 za Lantus SoloStar (kusowa kwa chidziwitso cha chipatala pakugwiritsa ntchito),
• Hypersensitivity pamagawo a mankhwala.

Mimba komanso kuyamwa

Mosamala, Lantus iyenera kugwiritsidwa ntchito panthawi yapakati.

Kwa odwala omwe ali ndi vuto la matenda am'mbuyomu kapena gestational shuga, ndikofunikira kuti azikhala ndi nthawi yokwanira yogwiritsira ntchito metabolism. Mu nyengo ya 1 ya mimba, kufunika kwa insulin kumatha kuchepa, mu 2nd ndi 3 trimesters ikhoza kukulira. Amayi akangobadwa kumene, kufunika kwa insulini kumachepa, chifukwa chake chiopsezo chokhala ndi hypoglycemia chikuwonjezeka. Pansi pa izi, kuyang'anira shuga wamagazi ndikofunikira.

M'maphunziro oyesera a nyama, palibe deta yachindunji kapena yosalunjika yomwe idapezeka pa embryotoxic kapena fetotoxic of insulin glargine.

Sipanakhalepo mayesedwe azachipatala a chitetezo cha mankhwala Lantus panthawi yapakati. Pali umboni wa kugwiritsa ntchito kwa Lantus mwa azimayi 100 oyembekezera omwe ali ndi matenda ashuga. Maphunziridwe ake ndi zotsatira za kutenga pakati pa odwalawa sizinasiyanane ndi zomwe zimachitika mwa amayi apakati omwe ali ndi matenda ashuga omwe amalandiranso kukonzekera kwina kwa insulin.

Amayi pakuyamwitsa, kuwongolera kwa insulin dosing regimen ndi zakudya kungafunike.

Gwiritsani ntchito ana

Pakalipano palibe zambiri zamankhwala zomwe zimagwiritsidwa ntchito mwa ana ochepera zaka 6.

Gwiritsani ntchito odwala okalamba

Mwa odwala okalamba, kuwonongeka kwa pang'onopang'ono mu ntchito ya impso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin.

Lantus si mankhwala osankhidwa pochiza matenda ashuga a ketoacidosis. Zikatero, njira yolimbikira ya insulin yochepa imalimbikitsidwa.

Chifukwa chazocheperako ndi Lantus, sizinali zotheka kuwunika kuti magwiridwe ake ndi otetezeka pochiza odwala omwe ali ndi vuto la chiwindi kapena odwala omwe ali ndi kuperewera kwapakati kapena koopsa.

Odwala omwe ali ndi vuto laimpso, kufunika kwa insulini kumatha kuchepa chifukwa chakufooka kwa njira zake zowonongera. Mwa odwala okalamba, kuwonongeka kwa pang'onopang'ono mu ntchito ya impso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin.

Odwala omwe ali ndi vuto lalikulu la kuchepa kwa hepatic, kufunika kwa insulin kumatha kuchepetsedwa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis ndi biotransfform ya insulin.

Pankhani ya kusakwanitsa kuyang'anira kuchuluka kwa shuga m'magazi, komanso ngati pali chizolowezi chokhala ndi hypo- kapena hyperglycemia, musanapitirize kukonza mankhwala, ndikofunikira kuyang'ana kulondola kwa kutsata njira, mankhwala omwe makonzedwe a mankhwalawo amathandizira komanso njira ya jekeseni yothandiza sc. , poganizira zonse zomwe zimayambitsa.

Nthawi ya kukonzekera kwa hypoglycemia zimatengera mawonekedwe a omwe amagwiritsidwa ntchito chifukwa cha insulin, motero, angasinthe ndikusintha kwa regimen yothandizira. Chifukwa cha kuchuluka kwa nthawi yomwe imagwira ntchito Lantus, munthu akuyenera kuyembekezera kuchepa kwa nthawi yayitali, pomwe m'mawa kwambiri izi zimachitika. Ngati hypoglycemia imapezeka mwa odwala omwe amalandila Lantus, mwayi wochepetsera kutuluka kwa hypoglycemia chifukwa cha nthawi yayitali ya insulin glargine uyenera kuganiziridwanso.

Odwala omwe ma episode a hypoglycemia atha kukhala ndi matendawo, kuphatikizapo ndi stenosis yayikulu yamitsempha yama ziwalo zam'mimba kapena ziwongo (chiopsezo cha matenda a mtima ndi matenda a chithokomiro), komanso odwala omwe ali ndi proliferative retinopathy, makamaka ngati salandira chithandizo cha kuchepa kwa khungu chifukwa cha kuchepa kwa masokonezo chifukwa cha hypoglycemia), kusamalidwa kwapadera kuyenera kuyang'aniridwa ndikuwunikidwa mosamala. shuga wamagazi.

Odwala ayenera kuchenjezedwa pazochitika zomwe zingayambitse kuchepa kwa ziwonetsero za hypoglycemia, kusatchulika kapena kusapezeka m'magulu ena omwe ali pachiwopsezo, monga:

• odwala omwe asintha kwambiri magazi a shuga,
• odwala omwe hypoglycemia imayamba pang'onopang'ono,
• odwala okalamba
• odwala a neuropathy
• odwala matenda ashuga a nthawi yayitali
• odwala omwe ali ndi mavuto amisala
• odwala omwe adachokera ku insulin ya nyama kupita ku insulin yaumunthu,
• odwala kulandira chithandizo chamankhwala ena ndi ena.

Zochitika zoterezi zimatha kuyambitsa kukula kwa hypoglycemia (kutayika kwa chikumbumtima) wodwala asanadziwe kuti akupanga hypoglycemia.

Masewera a hemoglobin atakhala abwinobwino kapena kuchepa kwambiri, ndikofunikira kulingalira za mwayi wokhala ndi zigawo za hypoglycemia zomwe zimachitika mobwerezabwereza (makamaka usiku).

Kutsatira kwodalirika kwa mankhwala a dosing, zakudya, ndi zakudya, kugwiritsa ntchito bwino insulin, komanso kuwongolera kuyambika kwa zizindikiro za hypoglycemia kumathandizira kuchepetsa kwambiri chiopsezo cha hypoglycemia. Pamaso pa zinthu zomwe zimapangitsa chidwi cha hypoglycemia, makamaka kuyang'anitsitsa ndikofunikira, chifukwa kusintha kwa insulin kungafunike. Izi ndi monga:

• Kusintha kwa malo makonzedwe a insulin,
• kuchuluka kwa insulin (mwachitsanzo, mukamachotsa kupsinjika),
• zodabwitsa, zolimbitsa thupi kapena zotalika,
• Matenda oyamba limodzi ndi kusanza, kutsekula m'mimba,
• kuphwanya zakudya ndi zakudya,
• adadula chakudya
• kumwa mowa
• matenda ena osagwirizana ndi endocrine (mwachitsanzo, hypothyroidism, kusakwanira kwa adenohypophysis kapena adrenal cortex),
• chithandizo chamankhwala ena.

Mu matenda apakati, kuyamwa kwamphamvu kwa magazi pamafunika. Mwambiri, kusanthula kumachitika kuti pakhale matupi a ketone mumkodzo, ndipo insulin dosing imafunikira nthawi zambiri. Kufunika kwa insulin nthawi zambiri kumachuluka. Odwala omwe ali ndi matenda amtundu wa 1 ayenera kupitiliratu kudya zakudya zochepa, ngakhale mutangodya zochepa kapena osadya, komanso kusanza. Odwala awa sayenera kusiya kuperekera insulin.

Oral hypoglycemic agents, ACE inhibitors, disopyramides, fibrate, fluoxetine, mao inhibitors, pentoxifylline, dextropropoxyphene, salicylates ndi sulfonamide antimicrobials amatha kupititsa patsogolo hypoglycemic zotsatira za insulin ndikuwonjezera kutanthauzira pakukula kwa hypoglycemia. Ndi kuphatikiza uku, kusintha kwa insulin glargine kungafunike.

Glucocorticosteroids (GCS), danazole, diazoxide, okodzetsa, glucagon, isoniazid, estrogens, progestogens, phenothiazine zotumphukira, somatotropin, sympathomimetics (mwachitsanzo epinephrine, salbutamol, terbutaline), mahomoni a chithokomiro, ) itha kuchepetsa hypoglycemic zotsatira za insulin.Ndi kuphatikiza uku, kusintha kwa insulin glargine kungafunike.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Lantus okhala ndi beta-blockers, clonidine, lithiamu salt, ethanol (mowa), kuwonjezeka ndi kuchepa kwa mphamvu ya insogulculin kumatha. Pentamidine ikaphatikizidwa ndi insulin imatha kuyambitsa hypoglycemia, yomwe nthawi zina imasinthidwa ndi hyperglycemia.

Pogwiritsa ntchito munthawi yomweyo mankhwala osokoneza bongo omwe ali ndi mtima wachifundo, monga beta-blockers, clonidine, guanfacine ndi reserpine, kuchepa kapena kusapezeka kwa zizindikiro za adrenergic antigenergic (activation ya amamvekere a dongosolo lamanjenje) ndi kukula kwa hypoglycemia ndikotheka.

Lantus sayenera kusakanikirana ndi insulin ina yokonzekera, ndi mankhwala ena aliwonse, kapena kuchepetsedwa. Mukasakanikirana kapena kuchepetsedwa, mawonekedwe amachitidwe ake amatha kusintha pakapita nthawi, kuphatikiza, kusakanikirana ndi ma insulin ena kungayambitse mpweya.

Mndandanda wa mankhwala Lantus

Zofanana muzochitika zamagulu:

• Insulin glargine,
• Lantus SoloStar.

Analogs kwa achire zotsatira (mankhwalawa zochizira insulin-wodwala matenda a shuga):

• Khalid
• Anvistat
• Apidra
• B. Insulin
• Berlinulin,
• Biosulin
• Glyformin
• Glucobay,
• Depot insulin C,
• Dibikor
• Isofan Insulin World Cup,
• Iletin
• Insulin Isofanicum,
• Tepi ya insulin,
• Insulin Maxirapid B,
• Insulin sungunuka
• Insulinnt
• Insulin Ultralente,
• Insulin yayitali
• Insulin Ultralong,
• Insuman
• Pakati
• Comb-insulin C
• Levemir Penfill,
• Levemir Phukira,
• Metformin
• Mikstard
• Monosuinsulin MK,
• Monotard
• NovoMiks,
• NovoRapid,
• Pensulin,
• Protafan
• Rinsulin
• Stylamine
• Thorvacard
• Tricor
• Ultratard
• Humalog,
• Humulin,
• Cigapan
• Erbisol.

Pakusowa kwa kufananiza kwa mankhwala omwe amagwira ntchito, mutha kuwonekera pazolumikizana pansipa ndi matenda omwe mankhwala oyenera amathandizira ndikuwona mawonekedwe ofananira achire.

Insulin Lantus (Glargine): Dziwani zonse zomwe mukufuna. Pansipa mupeza lolemba m'chinenerochi. Werengani kuchuluka kwa magawo omwe muyenera kulowa ndi momwe, muwerengere mankhwalawa, momwe mungagwiritsire ntchito cholembera cha Lantus Solostar. Mvetsetsani nthawi yayitali jekeseni wa mankhwalawa atayamba kugwira ntchito, omwe insulin ndiyabwino: Lantus, Levemir kapena Tujeo. Ndemanga zambiri za odwala omwe ali ndi matenda a shuga 2 ndi 1 amaperekedwa.

Glargin ndi timadzi tambiri tomwe timapanga kwa nthawi yayitali ndi kampani yotchuka yapadziko lonse Sanofi-Aventis. Mwina iyi ndiye insulin yotchuka kwambiri kwa odwala matenda ashuga achi Russia. Jakisoni wake amafunika kuthandizidwa ndi njira zamankhwala zomwe zimakulolani kuti mukhale ndi shuga 3.9-5,5 mmol / l khola maola 24 patsiku, monga mwa anthu athanzi. Dongosolo lomwe lakhala ndi matenda ashuga kwa zaka zopitilira 70 limalola akuluakulu ndi ana omwe ali ndi matenda ashuga kudziteteza ku zovuta zowopsa.

Werengani mayankho a mafunso:

Long insulin Lantus: nkhani yatsatanetsatane

Dziwani kuti insulin Lantus yowonongeka imawoneka yowoneka bwino. Mwa mawonekedwe a mankhwalawa, ndizosatheka kudziwa mtundu wake. Simuyenera kugula insulin ndi mankhwala okwera mtengo kuchokera m'manja mwanu, malinga ndi kulengeza kwanu. Pezani mankhwala a shuga kuchokera kuzipatala zotchuka zomwe zimatsatira malamulo osungira.

Kugwiritsa ntchito mankhwala Lantus

S / c imatumizidwa kudera lakhoma lamkati lamkati, minofu yolumikizidwa kapena ntchafu kamodzi patsiku, nthawi yomweyo. Mlingo umayikidwa payekha. Kuwongolera mankhwalawa, ma syringe okha omwe amaliza ku 100 IU ndi omwe ayenera kugwiritsidwa ntchito! Lantus sangathe kulowa mkati / mkati, popeza kuyambitsidwa kwazomwe muyezo wa sc makonzedwe kungayambitse kukula kwa hypoglycemia. Lantus sayenera kusakanikirana ndi insulin iliyonse kapena kuchepetsedwa, chifukwa izi zimatha kusintha nthawi / chikhalidwe cha mankhwalawo ndikupangitsa kuti pakhale matope.
Odwala omwe ali ndi vuto lachiwiri la matenda a shuga II, Lantus angagwiritsidwe ntchito nthawi imodzi ndi othandizira am'mlomo hypoglycemic, mu nkhani iyi, avareji yoyambirira ya Lantus ndi 10 IU / tsiku, kuyambira 2 mpaka 100 IU / tsiku.
Kusintha kuchokera ku insulin ina. Mukamachotsa insulin ndi nthawi yayitali kapena kuchitira insulin yayitali kupita ku Lantus, pakhoza kufunikira kusintha kwa mlingo wa insal insulin, komanso kusintha kwa mankhwalawa othandizira pakamwa a hypoglycemic.
Pofuna kuchepetsa chiopsezo cha nocturnal hypoglycemia kapena mamawa m'mawa kwambiri, odwala omwe amawachotsa kawiri kawiri kupita kuchipatala kupita ku Lantus kamodzi patsiku amafunika kuchepetsa mlingo wa insulin yoyamba ndi 20-30% m'milungu yoyamba yamankhwala. Kuchepetsa kotereku kwa inshuwaransi yoyenera kuyenera kuthetsedweratu kwakanthawi ndikuwonjezera kwa insulin yoyendetsedwa ndi chakudya. Pamapeto pa kukonzekera, Mlingo wa insulin umakonzedwanso.
Monga momwe amachitira ena a insulin, mwa odwala omwe amalandira Mlingo wambiri wa insulin chifukwa cha kupezeka kwa ma antibodies kwa insulin ya anthu, ndizotheka kusintha mayankho a insulin panthawi ya mankhwala ndi Lantus SoloStar, omwe amafunikira kusintha kwa mlingo. Izi ndizofunikira kuganizira odwala omwe ali ndi kunenepa kwambiri, ndikusintha kwa moyo wawo.
Lantus amatumizidwa s / c 1 nthawi patsiku, munthawi yomweyo, mosiyanasiyana.
Cholembera cha syringe chimakupatsani mwayi woti mulowetse mankhwalawo mumagawo a mtundu umodzi kuchokera pa 2 mpaka 40 IU. Mankhwalawa sangathe kulowa / mkati, popeza kukhazikitsidwa kwa mlingo wamba pamenepa kungayambitse kukula kwa hypoglycemia.
Palibenso kusiyana kwakukulu kwamankhwala m'madzi a m'madzi a m'magazi kapena m'magazi pambuyo poyendetsa mankhwala mpaka kukhoma kwam'mimba, minofu yoluma kapena ntchafu. Tsamba la jakisoni lisinthidwa mozungulira.
Ndizotheka kugwiritsa ntchito mankhwalawa pokhapokha ngati njira yothetsera vutoli pakuwoneka ndi yowonekera komanso yopanda utoto (kapena wopanda utoto), popanda tinthu tomwe timayang'ana ndi maso. Mukangosewera jekeseni, chotsani thovu lakumanzere mu syringe. Kuphatikiza mankhwalawo ndi othandizira ena sikuloledwa, chifukwa izi zimapangitsa kuti pakhale mpweya wabwino. Nthawi iliyonse ya jakisoni, gwiritsani ntchito singano yatsopano ku cholembera. Pambuyo pa jakisoni, singano imayenera kuchotsedwa ndikulembera cholembera popanda singano.
Palibenso chifukwa chogwirira cholembera musanagwiritse ntchito. Musanagwiritse ntchito, cholembera cha syringe chimayenera kuchitidwa kwa maola 1-2 kutentha kwa chipinda.
Kuti mugwirizanitse ndi singano, chotsani chizindikiro chodzitchinjiriza mu chida cha singano osachotsa singano zakunja ndi zamkati za singano. Phatikizani singano mosamala, pamodzi ndi kapu yake yakunja, ndendende mosungira mosabisa (mwa kupukusa mkati kapena kukanikiza, kutengera mtundu wa singano). Osalumikiza singano pamakona, chifukwa izi zitha kuchititsa kuti iphulike kapena insulini kuti ituluke m'dongosolo ndikutulutsa dost yolakwika. Mukamapaka, osakanikizira singano kwambiri. Muyenera kuwonetsetsa kuti batani la mlingo limakanikizidwa.
Jekeseni iliyonse isanachitike, kuyesedwa kwa chitetezo kuyenera kuchitidwa. Pa mayeso oyamba otetezeka, mlingo uyenera kukhala magawo 8 a insulin mukamagwiritsa ntchito cholembera chatsopano, chomwe kale sichinagwiritsidwe ntchito. Onetsetsani kuti chizindikiro chikuonetsa manambala 8. Ngati sizili choncho, gwiritsani ntchito cholembera chatsopano. Kwezani batani la mlingo momwe mungathere. Musabwezeretse kusintha kwa mlingo ngati mwatani.
Ngati cholembera chogwiritsidwa ntchito kale, ikani chisonyezo cha manambala ku nambala 2 posinthira chosinthira. Kusintha kwa dosing kumatha kuzungulira mbali iliyonse. Chotsani batani la mlingo. Chongani ngati nambala yomwe ili pa batani ikugwirizana ndi mlingo womwe wasankhidwa pa dosing switch. Zowopsa zakuda zimawonetsa kuchuluka kwa mayunitsi.Kashibu kotsiriza komaliza kumaonekera pa batani (gawo lake lokhalo ndi lomwe likuwoneka) limawonetsa mlingo womwe wapatsidwayo. Kuti muwone kaphinidwe komaliza, mutha kuzungulira kapena kupindika cholembera.
Chotsani singano zamkati ndi zakunja. Kugwira cholembera ndi singano kumtunda, ndikosavuta kukoka botolo ndi insulin ndi chala chanu kuti thovu lakumwamba litulukire kutsogolo kwa singano. Kanikizani batani la mlingo wonse kuti mutulutse mankhwalawo. Pankhaniyi, mutha kumva kulumikizana komwe kumasiya pambuyo pa batani la mlingo kukanikizidwa kwathunthu. Ngati insulini ikuwonekera pamphumi ya singano, chipangizocho chimagwira ntchito moyenera. Ngati insulini siziwoneka pamphuno ya singano, bwerezani malangizo omwe ali pamwambapa. Ngati dontho la insulini silikuwoneka ngakhale mutangobwereza mayeso otetezeka, fufuzani chipangizocho ngati ma bubble air. Ngati alipo, bwerezani mayesowo achitetezo mpaka atazimiririka. Pakakhala kuti kulibe mabulosi am'mlengalenga, singano imatha kubowoleka, m'malo mwake imayenera m'malo mwake.
Mukayika singano, kanikizani batani la njira yonse. Siyani singano pakhungu kwa mphindi zosachepera 10. Batani la mlingo liyenera kupitilizidwa mpaka singano itachotsedwa. Pambuyo pochotsa, singano imasulidwa ndikuzungulira kapu. Singano imatha kugwiritsidwa ntchito kamodzi.
Kuyendera kwa Tank kwa Insulin Yotsalira
Mulingo wosunga pang'onopang'ono umawonetsa kuchuluka kwa insulini yomwe ilipo mu cholembera. Kukula kwake sikumapangidwira kudziwa kuchuluka kwa insulin. Ngati pistoni yakuda ili pafupi ndi 40 koyambirira kwa kuyimitsidwa kwa khungu, izi zikutanthauza kuti kuchuluka kwotsalira kwa insulini mu cholembera cha syringe kuli pafupifupi 40 IU. Mapeto a kuyimitsidwa kwa khungu kumawonetsa kuti cholembera chimakhala ndi insulini pafupifupi 20 IU. Ndi insulin yotsika kwambiri mu tank, mutha kuwona kukhalapo kwake pogwiritsa ntchito batani la mlingo.
Osagwiritsa ntchito cholembera ngati simukutsimikiza kuti mwatsala ndi insulini yokwanira mlingo wotsatira. Mwachitsanzo, ngati chizindikiro cha mlingo chikuyikidwa pa 30 IU, koma batani la mlingo limatulutsidwa osapitilira 12 IU, izi zikutanthauza kuti IU 12 yokha ya insulin ndi yomwe ingabisidwe ndi cholembera ichi. Pazomwezi, 18 IU yomwe ikusowa imatha kuyambitsidwa pogwiritsa ntchito cholembera chatsopano kapena kugwiritsa ntchito cholembera chatsopano kupangira mlingo wonse wa 30 IU wa insulin.

Zotsatira zoyipa za mankhwala Lantus

Hypoglycemia ndiyo njira yovuta kwambiri pochizira matenda a insulin (makamaka akagwiritsidwa ntchito pamtunda waukulu). Hypoglycemia yayikulu ikhoza kuyambitsa matenda amitsempha ndipo imakhala chiopsezo m'miyoyo ya wodwalayo. Zotsatira zoyipa zomwe zimawonedwa pamayesero azachipatala ogwiritsira ntchito mankhwalawa zimaperekedwa pamagulu othandizira kuti achepetse kuwonetsa kwawo (kawirikawiri 1/10, nthawi zambiri 1/100, koma ≤1 / 10, kawirikawiri 1/1000, koma ≤ 1/100, kawirikawiri - 1/10000, koma ≤1 / 1000, nthawi zina ≤1 / 10000) ndikuchepetsa.
Kuchokera kumbali ya kagayidwe: nthawi zambiri - hypoglycemia. Hypoglycemia yayikulu kwambiri, makamaka mobwerezabwereza, imatha kuwononga dongosolo lamanjenje. Hypoglycemia yomwe imakhalapo kwa nthawi yayitali kapena imakhala yoopsa kwambiri. Odwala ambiri, zizindikiro za hypoglycemia zimayambitsidwa ndi zizindikiro za kukhazikika kwa adrenergic (kutsegula kwa dongosolo lazomvera poyankha hypoglycemia), kuchuluka kwa glucose kochulukirachulukira kumachepa, zizindikilo zambiri zotanthauzika.
Kuchokera ku chitetezo chamthupi: kawirikawiri - thupi lawo siligwirizana. Nthawi zina thupi lawo siligwirizana. Zomwe zimachitika ndi insulin (kuphatikizapo insulin glargine) kapena zigawo zikuluzikulu za mankhwalawo (zotupa zapakhungu ponseponse, angiodema, bronchospasm, hypotension ndi mantha) zitha kuwopseza moyo wa wodwalayo.
Kugwiritsa ntchito kukonzekera kwa insulin kungayambitse kuwoneka kwa ma antibodies kwa iwo.Mu maphunziro azachipatala, kupangika kwa ma antibodies kupita ku insulin ya anthu ndi insulin glargine kuwululidwa. Kupezeka kwa ma antibodies ku insulin kungafune kusintha kwa mlingo.
Kuchokera pamalingaliro: kawirikawiri - dysgeusia.
Kuchokera kumbali ya gawo la masomphenyawo: kawirikawiri - kuwonongeka kwa mawonekedwe. Kusintha kwatchulidwe ka shuga m'magazi kungayambitse kuwonongeka kwakanthawi chifukwa cha kusintha kwakanthawi kwa turgor ndi kukonzanso kwa mandala amaso. Kuwonongeka kwamawonekedwe kumalumikizidwa ndi kusokonezeka kwa kutulutsa.
Nthawi zambiri, retinopathy. Kupitilira patsogolo kwa glycemia kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy. Kukula mwachangu kwa mphamvu ya insulin mankhwala pambuyo poti chisachitike pakukonzanso glycemia kumawonjezera chiopsezo cha matenda ashuga a retinopathy. Odwala omwe akukhala ndi retinopathy ochulukirachulukira, makamaka iwo omwe sanatengepo fotokota, zovuta za hypoglycemic zingayambitse amaurosis.
Pa khungu ndi subcutaneous minofu: Nthawi zambiri - lipohypertrophy, kawirikawiri - lipoatrophy, yomwe imatsogolera kuchepa kwa insulin. Kusintha kosalekeza m'malo a jakisoni kumachepetsa kuuma kwa zinthu izi kapena kuziletsa. Mwina kukula kwa kanthawi kovutikira kwa khungu pamalo a jakisoni (mu 3-4% ya odwala), omwe amasowa nthawi yayitali masiku angapo mpaka milungu ingapo.
Kuchokera ku minculoskeletal system: kawirikawiri - myalgia.
Zomwe zimachitika kawirikawiri ndi kwanuko: Nthawi zambiri - zimachitika jekeseni malo (hyperemia, ululu, kuyabwa, ming'oma, kutupa kapena kutupa). Zochitika zambiri zakumaloko, monga lamulo, zimadutsa m'masiku angapo kapena masabata.
Nthawi zina, kukhazikitsidwa kwa kukonzekera kwa insulin kumayambitsa kuchedwa kwa sodium ndi madzi m'thupi ndi mawonekedwe a zotumphukira za edema, ngati ulamuliro wam'mbuyomu wa glycemic sunali wokwanira.

Malangizo apadera ogwiritsira ntchito mankhwala Lantus

Lantus sichisankho cha insulin pochiza matenda ashuga a ketoacidosis. Zikatero, iv ikulimbikitsa insulin yosavuta.
Musanayambe kusintha kwa mankhwalawa ngati mukulumikizana ndi glucose osakwanira kapena chizolowezi chokhala ndi vuto la hypoglycemia, ndikofunikira kuyang'ana momwe wodwalayo akutsatira njira yolandirira mankhwala, njira ya jakisoni, kulondola kwa njira yolandirira mankhwala ndi zina zofunika.
Hypoglycemia. Chifukwa cha pharmacokinetics ya Lantus (insulin yochulukirapo), kupezeka kwa hypoglycemia kumakhala koyamba m'mawa kwambiri kuposa usiku.
Ndi kusamala kwambiri komanso kuyang'anira glycemia nthawi zonse, mankhwalawa amagwiritsidwa ntchito mwa odwala omwe hypoglycemia imakhala yolimba kwambiri, mwachitsanzo, odwala omwe ali ndi vuto lalikulu la mitsempha ya mitsempha kapena mitsempha ya m'magazi (chiopsezo cha mtima wamatumbo kapena matenda a chithokomiro), komanso odwala omwe akuchulukana retinopathy, yomwe siinachite photocoagulation (chiopsezo chochepa maurosis).
Kutsatira ndi regimen ya mankhwala ndi zakudya, kutsata insulin yoyenera komanso kudziwa zizindikiro za hypoglycemia ndikofunikira kuti muchepetse chiopsezo cha hypoglycemia.
Zovuta zomwe zingayambitse hypoglycemia zimaphatikizapo: kusintha malo opangira jakisoni, kuwonjezera insulin (mwachitsanzo, atachotsa kupsinjika), kuchita zolimbitsa thupi kwambiri, matenda opatsirana, kusanza, kutsegula m'mimba, kudya chakudya, kumwa mowa, matenda ena osakwanira a endocrine (hypothyroidism, kusakwanira ntchito pituitary kapena adrenal gland), kugwiritsa ntchito mankhwala munthawi yomweyo.
Nthawi zina, Zizindikiro zakutsogolo kwa hypoglycemia zimatha kusintha, kutaya mphamvu kapena kusakhalapo: mbiri yayitali ya matenda a shuga, matenda amisala, malingaliro am'mimba, kugwiritsa ntchito mankhwala ena, kusintha kuchokera ku insulin yakuchokera kwa nyama kupita kwa anthu, komanso odwala okalamba kapena pang'onopang'ono kukula kwa hypoglycemia kapena kusintha kwa glycemic. Pankhaniyi, hypoglycemia yayikulu imatha kukhala ndi (kutayika kwa chikumbumtima) ngakhale wodwala asanadziwe tanthauzo la hypoglycemia
Ndi mtundu wabwinobwino kapena wochepetsedwa wa glycosylated hemoglobin, ndikofunikira kulingalira kuthekera kobwereza, makamaka (usiku) zochitika za hypoglycemia.
Matenda ogwirizana . Pamaso pa matenda ophatikizika, kuwunika kwambiri kwa kagayidwe kake ndikofunikira. Nthawi zambiri, kutsimikiza kwa ma ketoni mumkodzo amasonyezedwa, nthawi zambiri ndikofunikira kusintha kwa insulin. Kufunika kwa insulin nthawi zambiri kumachuluka. Odwala omwe ali ndi matenda amtundu wa shuga I ayenera kudya chakudya chamagulu, ngakhale pang'ono, komanso ngati akusanza, ndi zina zambiri. Osadumphiratu jakisoni wa insulin.
Kuchepa kwa chiwindi kapena impso. Chifukwa chosakwanira kwenikweni, kugwira ntchito ndi chitetezo cha Lantus kwa odwala omwe ali ndi vuto la chiwindi kapena omwe ali ndi kuchepa kwapakati komanso / kapena kuvulala kwambiri kwaimpso sikunafotokozedwe. Odwala omwe ali ndi vuto la impso, kufunika kwa insulin kumatha kuchepa chifukwa kuchepa kwa insulin metabolism. Odwala okalamba, kuchepa kwaimpso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin.
Odwala omwe ali ndi vuto la chiwindi cholakwika kwambiri, kufunika kwa insulini kumatha kuchepetsedwa chifukwa cha kuchepa kwa gluconeogeneis komanso kuchepa kwa insulin metabolism.
Mimba komanso kuyamwa . Palibe zokuchitikirani zamankhwala zozikidwa pa zamankhwala zoyeserera zamagwiritsidwe ntchito ka insulin glargine panthawi yapakati. M'maphunziro a preclinical, panalibe mwachindunji teratogenic komanso embryotoxic pa nthawi ya mimba, komanso pobala mwana ndi kukula pakatha nthawi yobereka.
Chifukwa chake, ayenera kusamalidwa popereka mankhwala. Pa nthawi yoyembekezera, kuphatikizapo odwala omwe ali ndi matenda a shuga, ndikofunikira kuwongolera glycemia. Kufunika kwa insulin kumatha kuchepetsedwa mu trimester yoyamba ya kutenga pakati ndikuwonjezereka mu trimester yachiwiri ndi yachitatu. Pambuyo pobadwa, kufunika kwa insulin kumachepa (chiwopsezo cha kukhala ndi hypoglycemia chikuwonjezeka), chifukwa chake ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi am'magazi. Panthawi yoyamwitsa, kusintha kwa insulin ndi zakudya kumafunikiranso.
Ana. Kuchita bwino ndi chitetezo cha kugwiritsa ntchito Lantus mwa ana kwatsimikiziridwa pokhapokha ngati kumagwiritsidwa ntchito madzulo. Lantus sagwiritsidwa ntchito mwa ana ochepera zaka 6, popeza kutha ndi chitetezo cha mankhwalawa mu ana amisinkhu iyi sizinatsimikizidwe.
Kutha kukopa momwe zinthu zikuyendera mukamayendetsa magalimoto ndikugwiritsa ntchito njira. Pankhani yosankha mosakwanira kwa mankhwalawo kapena kusinthira kwa mankhwalawo, komanso pakakhala kuti sikulandira chakudya mosagwirizana kapena zakudya zosakhwima, kusinthasintha kwamphamvu kwa glucose m'magazi amwazi ndikotheka, makamaka ku hypoglycemia, komwe kumatha kuwononga kuyendetsa magalimoto, makamaka koyambirira nthawi yamankhwala, komanso kumwa munthawi yomweyo mowa kapena mankhwala osokoneza bongo omwe ali pachiwonetsero chachikulu cha mantha.

Zochita ndi mankhwala a Lantus

Hypoglycemia imatha kugwiritsa ntchito limodzi munthawi yomweyo kugwiritsa ntchito mankhwala a Lantus omwe ali ndi milomo ya hypoglycemic, ACE inhibitors, disopyramide, fibrate, fluoxetine, MAO zoletsa, pentoxifylline,propoxyphene, salicylates ndi sulfonamides. Kuchita bwino kwa Lantus kumatha kuchepetsedwa ndi corticosteroids, danazol, diazoxide, glucagon, isoniazid, estrogens ndi progesterone, zotengera za phenothiazine, somatropin, sympathomimetics (epinephrine, salbutamol, terbutaline), thyroid mahomoni, atypicalhibacterizhi. Ma blockers a Β-adrenoreceptor, clonidine, mchere wa lithiamu, pentamidine kapena mowa amathanso kupanga mphamvu kapena kufooketsa mphamvu ya insogulin. Pogwiritsa ntchito munthawi yomweyo ma β-adrenergic receptor blockers, clonidine, guanethidine, reserpine ndi insulin, zotsatira zawo zimatha kuchepa kapena kutha, komanso kufooketsa zizindikiro za kutsutsana ndi adrenergic.
Lantus sayenera kusakanikirana ndi mankhwala ena. Syringe yoyambitsa Lantus isakhale ndi kuchuluka kwa mankhwala ena.

Mankhwala osokoneza bongo a Lantus, zizindikiro ndi chithandizo

Zingayambitse hypoglycemia yayitali komanso yayitali. Hypoglycemia yofatsa imatha kuthetsedwa pakamwa. Woopsa hypoglycemia (minyewa mawonekedwe, chikomokere), mu mnofu kapena subcutaneous makonzedwe a glucagon, mtsempha wa magazi m`kati wofunikira. Pambuyo poyimitsa hypoglycemia, kuwunika wodwala ndi kudya kwa kabohaini kumafunika, popeza mikhalidwe ya hypoglycemic imatha kubweranso kwakanthawi.

Kusunga mankhwala Lantus

Kutentha kwa 2-8 ° C. Osalola kuzizira. Osayika vial mu mufiriji. Mukamagwiritsa ntchito, sungani kunja kutentha mpaka 25 ° C. Botolo lotseguka liyenera kugwiritsidwa ntchito masiku 28 likasungidwa m'malo ozizira, amdima mpaka 25 25 C (koma osati mufiriji).

Mndandanda wa malo ogulitsa mankhwala komwe mungagule Lantus:

Mlingo

1 ml yankho lili

yogwira mankhwala - insulin glargine (equimolar unit of insulin) 3.6378 mg (100 mayunitsi)

omwe amapeza yankho mu cartridge: metacresol, zinc chloride, glycerin (85%), sodium hydroxide, hydrochloric acid wokhazikika, madzi a jakisoni.

omwe amapeza yankho mu vial: metacresol, polysorbate 20, zinc chloride, glycerin (85%), sodium hydroxide, hydrochloric acid wokhazikika, madzi a jekeseni.

Transparent wopanda khungu kapena pafupifupi wopanda mafuta.

Mankhwala

Poyerekeza ndi NPH-insulin, kuchuluka kwa ma seramu insulin m'maphunziro athanzi komanso odwala omwe ali ndi matenda ashuga pambuyo poyambira kulowetsedwa kwa insulin glargine adawonetsa kuchepa komanso kuyamwa kwakanthawi, komanso kusapezeka kwa nsonga. Chifukwa chake, zoimbazo zinali molingana ndi mawonekedwe aposachedwa a pharmacodynamic ntchito ya insulin glargine. Chithunzi 1 chikuwonetsa ntchito za insulin glargine ndi NPH-insulin motsutsana ndi nthawi. Ndi kukhazikitsidwa kamodzi patsiku, kuchuluka kwa insulin glargine m'magazi kumatheka patatha masiku 2-4 pambuyo pa mlingo woyamba. Ndi mtsempha wamagazi, theka la moyo wa insulin glargine ndi insulin ya anthu anali ofanana.

Pambuyo subcutaneous jakisoni wa Lantus mwa odwala matenda a shuga, insulin glargine imapangidwa mofulumira pamapeto pa polypeptide beta unyolo kuti apange ma metabolites awiri a M1 (21A-Gly-insulin) ndi M2 (21A-Gly-des-30B-Thr insulin). Mu plasma, gawo lalikulu lozungulira ndi metabolite M1. Kutulutsidwa kwa metabolite M1 kumawonjezeka malinga ndi mlingo wa Lantus.

Zotsatira za Pharmacokinetic ndi pharmacodynamic zikuwonetsa kuti zotsatira za jekeseni wa subcutaneous wa Lantus zimachitika makamaka pakudzipatula kwa M1 metabolite. Insulin glargine ndi metabolite M2 sizinapezeke mwa odwala ambiri, atapezeka, kuphatikiza kwawo kunali kosadalira mlingo womwe Lantus anali nayo.

M'mayeso azachipatala, kusanthula kwamagulu omwe amapangidwa ndi zaka komanso jenda sizinawonetse kusiyana kulikonse pakuwoneka bwino komanso chitetezo pakati pa odwala omwe amathandizidwa ndi insulin glargine ndi anthu onse omwe adaphunzira.

Pharmacokinetics mwa ana a zaka 2 mpaka 6 zokhala ndi matenda a shuga 1 adayesedwa pa kafukufuku wina wamankhwala (onani "Pharmacodynamics"). Ana ochepera "insulin" a insulin glargine ndi ma plasma metabolites ake akuluakulu M1 ndi M2 adayezedwa ana omwe amapezeka ndi insulin glargine, ndipo zidapezeka kuti zitsanzo za plasma za ndende zinali zofanana ndi zitsanzo za achikulire, umboni wotsimikizira kuchuluka kwa insulin glargine kapena metabolites yake ndi makonzedwe autali kulibe.

Insulin glargine ndi analogue ya insulin ya anthu, yopangidwira kuti isungunuke pakubwera pH. Imasungunuka kwathunthu pa acidic pH ya Lantus® In injion (pH 4). Pambuyo pothandizidwa ndi subcutaneous, yankho la acidic siligwirizana, zomwe zimapangitsa kupangika kwa microprecipitate, komwe insulin glargine imatulutsidwa mosalekeza pang'ono, ndikupatsanso mbiri, yopanda chiwopsezo, chodziwikiratu cha nthawi yayitali.

Kumangiriza kwa ma insulin receptors: mu vitro kafukufuku amawonetsa kuti kuyanjana kwa insulin glargine ndi metabolites M1 ndi M2 kwa insulin receptors yaumunthu ndizofanana ndi insulin yamunthu.

IGF-1 receptor yomangiriza: kuyanjana kwa insulin glargine kwa IGF-1 receptor wamunthu kuli pafupifupi nthawi 5-8 kuposa zomwe zimapangitsa insulin (koma pafupifupi 70-80 nthawi yotsika kuposa IGF-1), pomwe M1 metabolites ndi M2 yomangiriza ku IGF-1 receptor yokhala ndi mgwirizano wotsika pang'ono poyerekeza ndi insulin ya anthu.

Chiwonetsero chonse cha insulin (insulin glargine ndi metabolites), chotsimikizika mwa odwala omwe ali ndi matenda osokoneza bongo 1, anali otsika kwambiri kuposa momwe amafunikira hafufuyi yotsimikizika pakugwidwa kwa IGF-1 receptor komanso kuyambitsa njira ya mitogenic proliferative yotsatira ya IGF-1 receptor . Kuzungulira kwa thupi kwa endo native IGF-1 kumatha kuyambitsa njira ya mitogenic prolifative, komabe, zozama zochizira zotchulidwa panthawi ya insulin, kuphatikizapo Lantus, ndizotsika kwambiri kuposa kutsika kwa pharmacological komwe kumafunikira kuyambitsa njira ya IGF-1.

Chochita chachikulu cha insulin, kuphatikiza insulin glargine, ndikuwongolera kagayidwe ka glucose. Insulin ndi ma analogi ake amachepetsa kuchuluka kwa shuga m'magazi athunthu, makamaka minyewa yam'mimba ndi minyewa ya adipose, komanso kuponderera kupangika kwa glucose m'chiwindi. Insulin imachepetsa lipolysis mu adipocytes, linalake ndipo tikulephera kuphatikiza mapuloteni. Kafukufuku wa zamankhwala ndi zamankhwala awonetsa kuti ma insulin glargine ophatikizidwa ndi insulin komanso mankhwalawa anali ofanana pakaperekedwa pa mlingo womwewo. Monga ndi ma insulin onse, zolimbitsa thupi ndi zinthu zina zimatha kusokoneza nthawi ya insulin glargine.

M'maphunziro ogwiritsa ntchito euglycemic clamp mwa odzipereka athanzi komanso odwala omwe ali ndi matenda a shuga 1, momwe angapangire insulin glargine pang'onopang'ono kuposa insulin yaumunthu, zotsatira za insulin glargine zinali zosalala komanso zopanda pake, kutalika kwake kunali kutalitali.

Nthawi (maola) itadutsa pambuyo pakujambulira

Mapeto a nthawi yowonera

* amatanthauzidwa ngati kuchuluka kwa glucose komwe kumayambitsidwa kukhalabe ndi glucose wokhazikika (pafupifupi ola limodzi).

Kuchitanso kwakanthawi kwa subcutaneous insulin glargine kumakhudzana makamaka ndi kuyamwa pang'onopang'ono, komwe kumalola kuti mankhwalawa azigwiritsidwa ntchito kamodzi patsiku.Mwa anthu osiyanasiyana komanso kwa munthu yemweyo, nthawi yomwe insulin imafanana ndi zomwe zimafanana, monga insulin glargine, imatha kusiyanasiyana.

Mu kafukufuku wazachipatala, zizindikiro za hypoglycemia kapena zizindikiro za kutsata kwa mahomoni mwa odzipereka athanzi komanso odwala omwe ali ndi matenda amtundu wa 1 anali omwewo pambuyo pa kuperekedwa kwa insulin glargine ndi insulin ya anthu.

Insulin lantus ndiofananira kwake kofanana. Insulin Lantus ndi mawonekedwe ake: timawerengera molondola ndi mamvedwe a m'mawa ndi madzulo

Insulin yomwe imadalira matenda a shuga amachokera ku matenda a shuga. Mwanjira imeneyi ya matenda ashuga, ma cell a pancreatic beta satulutsa zokwanira kapena satulutsa ma cell a insulin (Insulinum), omwe amachititsa kuti shuga agwiritsike ntchito m'maselo a minofu ya minofu.

Kuti athandize thupi kuyamwa glucose ndipo asafe chifukwa cha kuledzera kwa shuga, odwala amakakamizidwa kubaya insulin yopanga ma cell ofanana ndi anthu, kuphatikiza mankhwala a Insulin Lantus ndi analogies.

Zambiri ndi makanema mu nkhaniyi adzaperekedwa pamutuwu. Mwa njira, itha kukhala yothandiza osati kwa odwala matenda a shuga okhaokha omwe amakhala ndi T1DM, komanso kwa odwala omwe samadalira insulini, komanso azimayi oyembekezera omwe ali ndi vuto la matenda ashuga.

Ma jakisoni "osakhalitsa" a insulin yayitali amatha kuperekedwa ndi iye, mwachitsanzo, kuti alipire kuchuluka kwa matendawa nthawi yayitali, panthawi ya SARS kapena matenda ena opatsirana. Athandizira kupewa kapangidwe ka matenda ashuga mu mtima, impso ndi maso.

Pazithandizo zamafuta obwera chifukwa cha matenda ashuga, mitundu 5 ya insulin yakonzekereratu yapangidwa ndipo ikupangidwa:

• bolus () - amagwiritsidwa ntchito musanadye, kapena amayamba kuwongolera mwachangu kuchuluka kwa shuga m'magazi,
• NPH (NPH) ndi woyambira (wapakati komanso wanthawi yayitali) - ofunika kuthana ndi magazi pakapita nthawi pamene ma bolus insulin ayimitsa kale ntchito yawo,
• maziko oyambira (kuphatikiza kwa mafomu a bolus ndi NPH kapena basal, komanso kuphatikiza kwa NPH ndi basal) ndizosavuta, koma kugwiritsidwa ntchito kwawo kumayambitsa chisokonezo chachikulu komanso kufunikira kwa kuukira kwa hypoglycemic chifukwa cha izi.

Lantus ndi mtundu wakale wa basal wokonzekera. Kwenikweni, Lantus ndi dzina lodziwikiratu la analogue yoyamba ya insulinum yamunthu yokhala ndi maola 24 opanda pake, yomwe idapangidwa ndi kampani yapadziko lonse yamankhwala Sanofi-Aventis, yokhala ndi likulu ku Paris.

Lantus yogwira ntchito ndi mtundu wosinthika wa insulin glargine. Lantus imakhala ndi 1 ml 100 IU (3.6378 mg) chinthu chofanana ndi timadzi tamunthu, momwe ma asparagine ochokera ku amino acid a-unyolo amaloledwa ndi molekyulu ya glycine, ndipo zotsalira za 2 arginine "zimangika" mpaka kumapeto kwa chingwe cha b.

Chifukwa cha mawonekedwe awa, mahomoni opangidwa mwaluso awa ali ndi izi:

• mankhwalawa amatsata bwino kwambiri mwachilengedwe monga insulinum m'thupi la munthu,
• jakisoni amachitika kamodzi kokha patsiku, ndipo safunikira kuti asokonezedwe kugona kuti apange jakisoni wowonjezereka, kupereka chiwongolero cha shuga usiku,
• musasakanikize mankhwalawa musanabale,
• glycemia imalipidwa bwino polipirira shuga,
• chiopsezo cha hypoglycemia ndi chocheperako,
• Mosiyana ndi mankhwala ena, palibe kusiyana komwe kumadula - pansi pa khungu pamimba, ntchafu kapena phewa,
• mchitidwewo ndi wosalala, wokumbukira mbiri yodula ya kulowetsedwa kosalekeza kwa kulowerera kwa insulin,
• Amasintha kagayidwe kazakudya konse.

ChidwiPa anthu odwala matenda ashuga okhala ndi nthawi yochepa kapena yochepetsedwa ya hemoglobin yolephera, nthawi zina amayamba kuwazindikira usiku.

Malangizo a Insulin Lantus ogwiritsira ntchito akuwonetseratu kuti odwala matenda ashuga ayenera kukumbukira - kuchuluka kwa zochitika zolimbitsa thupi kumakhudzanso mawonekedwe a glargine. Chifukwa chake, musanaphunzire kapena kuchita masewera olimbitsa thupi kapena kuchita zina zolimbitsa thupi, mwachitsanzo, kugwira ntchito m'munda), kuchuluka kwa glucose ndikofunikira, ndipo ngati kuli kotheka, kukonza ndi insulini yochepa kwambiri.

Kwa mawu. Monga mankhwala ena aliwonse okhala ndi mahomoni, Lantus insulin glargine kapena mawonekedwe ake amayenera kusungidwa pang'onopang'ono pa firiji, pamtunda wa mpweya wa 2 mpaka 8 digiri Celsius. Mukatsegula mankhwalawa, moyo wake wa alumali ndi pafupifupi masiku 40.

Analogs Lantus

Chofanana ndi Lantus ndi cholembera cha Tujeo SoloStar. Kodi pali kusiyana kotani pakati pawo? Chithandizo cha Tujeo ndichofanana ndi cha Lantus - glargine, koma mu 1 ml yankho la Tujeo ili ndi katatu kuposa Lantus.

Izi zimakuthandizani kuti muwonjezere zochulukazo kuyambira maola 24 mpaka 35, komanso zimachepetsa kwambiri chiwopsezo cha hypoglycemic. Tsoka ilo, pali ndemanga zambiri pa Tujeo pa intaneti, koma mwachiwonekere iwo amawerengera molakwika ndi odwala matenda ashuga a kusintha kwa mankhwala kuchokera nthawi yayitali kupita kwina.

Pakadali pano, fanizo la Lantus SoloStar (insulin glargine) ndi:

1. Levemir ndi Levemir Flexpen ochokera ku Novo Nordisk. Maziko awo ndi yogwira mankhwala a insulin. Mosiyana ndi kukonzekera kwa insulin yayitali, ikhoza kuchepetsedwa, ndikupangitsa kuti ikhale mankhwala abwino kwambiri a ana ochepa odwala matenda ashuga. Mutha kudziwa zambiri za maubwino omwe amachokera mu vidiyoyi.

1. Tresiba, Tresiba FlekTach ndi Tresiba Penfill kutengera yogwira insulin degludec. Zololedwa kuti azigwiritsidwa ntchito ndi ana azaka 12 zakubadwa. Imakhala nthawi yayitali kwambiri maola 42. Kugwiritsa ntchito ma cell a insulin oterewa kumathandizira kuyendetsa zinthu zosasangalatsa ngati za anthu odwala matenda ashuga monga "m'mawa kutacha".

Kwa iwo omwe ali ndi luso lazachuma, ma endocrinologists akunja amalimbikitsa kusintha kuchokera ku Lantus kupita ku Levemir wautali kapena, makamaka, kukhala wautali kwambiri wa onse omwe alipo, Tresiba insulin. Anulin yomaliza ya insulin Lantus - degludec, imawerengedwa kuti ndiyo insulinum yabwino koposa. Komabe, zabwino kwambiri, nthawi zonse zimakhala zotsika mtengo kwambiri.

Lantus SoloStar ndi chiyani?

Lantus SoloStar sagwira ntchito pa glargin analogues. Kusiyana pakati pa "wamba Lantus" ndi SoloStar ndi mawonekedwe a "phukusi" la glargine yogwira ntchito. Kwenikweni, SoloStar ndi dzina lobwezeretsera cholembera wapadera wa cholembera ndi singano imodzi imodzi yake.

Zomwe zimagwiritsidwa ntchito pakugwiritsira ntchito insulin yayitali panthawi yapakati

Amayi oyembekezera omwe amafunikira kubayitsa mahomoni a insulin ayenera kukumbukira, ngakhale kuti chinthuchi sichitha kudutsa placenta, ndikofunikira kuti zotsatira za mankhwalawa pa mwana wosabadwayo zimaphunziridwa ndi sayansi ya zamankhwala, ndipo chitetezo chake chimatsimikiziridwa ndi mayeso olamulidwa mosasamala.

Masiku ano, malingaliro ndi malingaliro otsatirawa alipo:

1. Ziyeso zazikulu za Tujeo ndi Tresib ndi kutenga nawo gawo kwa amayi apakati sizinachitikebe, motero sikulimbikitsidwa kuzigwiritsa ntchito pano.
2. Chitetezo kwa mwana wosabadwa wa Lantus sichinatsimikiziridwe kwathunthu, koma chidziwitso chachikulucho chidapeza padziko lonse lapansi, ndi zotsatira zabwino popanda zotsatira zoyipa pa thanzi la makanda, zidapereka mwayi, mu 2017, kuvomereza mwalamulo kugwiritsidwa ntchito kwawo ku Russia.
3. Ambiri ophunziridwa ndi asing'anga Levemir.Ndikulimbikitsidwa kuti ligwiritsidwe ntchito panthawi yonse yomwe muli ndi pakati komanso kwa amayi omwe ali ndi matenda osokoneza bongo kuti asinthe kwa nthawi yomwe akukonzekera kutenga pakati.

Kwa mawu. Mndandanda wamahomoni amfupi a insulin, omwe ali ndi chitetezo chotsimikizika pakukula kwa mwana wosabadwayo, adaphatikiza Humalog ndi Novorapid, ndipo Apidra adagwera pagawo loletsedwa.

Kodi mlingo wa basal insulin amawerengedwa bwanji?

Musanawerengere kuchuluka kwa mankhwala a insulini ndi imodzi mwazitali za insulin, muyenera kupita patsogolo:

• Mwandimomwene komanso mwakukhonda kupita kudya zakudya zamafuta ochepa. Popanda kutsatira kwambiri, ndizosatheka kuti mupeze kuthamanga kwa magazi a shuga pazigawo za 3,9-5,5 mmol / L, motero kupewa kutulutsa zovuta za matenda ashuga.

• Yambitsani kuchita mwatsatanetsatane komwe muyenera kulemba:
  1. Zizindikiro za shuga m'magazi, osachepera - m'mawa m'mimba yopanda chakudya, pambuyo pa maola atatu mutadya kadzutsa, musanadye nkhomaliro ndi maola atatu pambuyo pake, komanso musanadye chakudya chamadzulo komanso musanayambe kugona,
  2. zakudya, zakudya, zakumwa,
  3. kumwa mankhwala owonjezera
  4. Kodi jakisoni wa insulin amatenga nthawi yanji, amatenga chiyani, jakisoni, ndipo amatuluka
  5. chiyani ndi momwe zochita zolimbitsa thupi zimakhudzira kuchuluka kwa shuga m'magazi (miyezo ya glucose ndiyofunikira isanachitike kapena itatha),
  6. kuyankha kwamthupi - moyo wabwino ndi shuga: mutatha kupsinjika, nyengo, mutamwa zakumwa zoledzeretsa komanso khofi.
• Dziwani bwino chakudya cham'mawa - musadye pasanathe maola 5 musanakagone.
• Sankhani nthawi yokhazikika, makamaka ola limodzi musanagone, kuti mulemere tsiku lililonse. Osakhala aulesi kulemba ziwerengerozi mu diary.

Yesani kupanga zolemba mwatsatanetsatane komanso mwatsatanetsatane. Osawononga ndalama, ndipo mkati mwa masiku 4-7, yeretsani kuchuluka kwa shuga pafupipafupi.

Malangizo. Mahomoni a insulin ataliitali amatha kubayidwa musanagone kapena m'mawa kwambiri. Jakisoni wamadzulo amathandizira kuchotsa matendawa m'mawa mwakuwongolera shuga usiku ndi m'mawa. Ngati zalembedwa kuti kudya chakudya chamadzulo koyambirira kumakupatsani mwayi wokhala ndi shuga m'magulu a 4,5-5,5 mmol / l, ndiye kuti simukufunika kuti mupeze insulin ya basal musanagone.

Momwe mungawerengere kuchuluka kwa insulin yayitali usiku

Poyamba, kugwiritsa ntchito zolemba zam'makalata, mwa kuwerengera, onani kusiyana kocheperako, chifukwa m'masiku atatu omaliza, muyezo wama glucose womwe umayesedwa madzulo komanso pamimba yopanda kanthu m'mawa (MRHU). Kenako pangani mawerengeredwe malinga ndi njira yolimbikitsidwa ndi American endocrinologist Richard Bernstein.

Mangirirani nambala yakufika ku 0.5. Osadandaula ngati mlingo woyambira wolandila ndi wocheperako - 1 kapena 0,5 ma unit. Menyani, ndipo musaiwale kuwongolera shuga ndi glucometer m'mawa. Ngati patatha masiku atatu a chithandizo chotere simukwaniritsa zomwe mukufuna za 4.0-5,5 mmol / l, onjezani mlingo woyambira ndi mayunitsi 0,5, ndikuvulaza kwina kwa 3 pm. Kodi sindikugwiranso ntchito? Kwezani zigawo zina za 0,5.

Ndikofunikira. Choyamba, mtengo wambiri wa glucose sugwirizana ndi "usiku" wa basal insulin. Kachiwiri, musathamangire pakumwa mlingo woyenera wa usiku, onetsetsani kuti mukusankha "masitepe" a masiku atatu.

Chimachitika ndi chiani ngati muphonya jakisoni?

Mudzakhala ndi shuga wambiri chifukwa chosowa insulin mthupi. Molondola, chifukwa cha kulakwitsa kwa msana wa insulin ndi kufunikira kwa thupi. Kuchuluka kwa glucose kumathandizira kukulitsa.

Woopsa milandu, zovuta pachimake kuonedwa: matenda ashuga ketoacidosis kapena hyperglycemic chikomokere. Zizindikiro zawo ndi kusokonezeka kwa chikumbumtima. Amatha kupha.

Momwe mungawerengere mlingo wa basal insulin m'mawa

Malangizo a Dr. R. Bernstein ndi awa:

• Muli ndi njala tsiku limodzi pakumwa tiyi ndi madzi, kulemba zolembedwazo m'maola omwe alembedwa patebulopo.

• Kuchokera pamtengo wotsika kwambiri wa shuga, pamenepa - 5.9, chotsani nambala 5, yomwe ndi mulingo woyenera wa shuga wamba wamagazi.Chifukwa chake, RSNNS (kusiyana pakati pa shuga wotsika kwambiri komanso wabwinobwino).
• Kenako, werengani kuwerengera motengera, kukumbukira kuti kulemera kuyenera kulembedwa makilogalamu, koma molondola ndi nambala imodzi pambuyo pamawu omaliza.

• Kuti mutsimikizire kuthekera kapena kusintha mlingo, tsatirani izi:
  1. Lowani m'mawa mlingo
  2. dumphani chakudya cham'mawa, nkhomaliro komanso zakudya zam'mano (mutha kumwa madzi ndi tiyi wopanda mafuta),
  3. masana, musanadye chakudya cham'mawa, pangani miyeso 4-5 ndi glucometer, ndipo potengera izi mutha kusankha kuti musinthe mlingo wa mankhwala ndipo ngati kuli komwe, kutsika, kuwonjezeka kapena kuchuluka, izi zikuyenera kuchitika.

Yang'anani! Mukabayidwa jakisoni wa insulini iliyonse, simusowa kudya.

Ndipo pomaliza, tikufuna kupereka malangizo kuchokera kwa opanga ma endocrinologists:

• osazimitsa shuga wambiri mukatha kudya ndi insulin yotalikilapo, gwiritsani ntchito mafupiafupi kapena owonjezera okha,
• Treshiba kokha ndi yoyenera jakisoni imodzi patsiku, koma izi ndizodziwikiratu, ndipo zimafunikira chitsimikiziro chothandiza,
• Ndikwabwino kupaka Lantus, Levemir ndi Tujeo m'mawa ndi madzulo, kuwerengera malingana ndi njira yomwe ili pamwambapa,
• mukasintha kuchokera ku insulin yowonjezereka kupita kwina, kuonjezera mlingo woyambira ndi 30% ya mtengo wowerengedwa, ndipo patatha masiku 10, onani kulondola kwake - ngati kuli kotheka, onjezerani kapena muchepe.

Chithandizo chokhacho cha mtundu woyamba wa shuga ndi mtundu wachiwiri wa shuga ndi kuphatikiza zakudya zamagulu ochepa komanso zosankha zochepa zomwe zimafunikira, zonse zokonzekera insulin kapena zazifupi. Kuti muchepetse kulemera kwa thupi, kugonjetsa kapena kuletsa kukula kwa insulin m'misempha, komanso kupewa matenda ashuga a mtima, osagwiritsa ntchito masewera olimbitsa thupi - zovuta zamphamvu zolimbitsa thupi ndi maphunziro a mtima - simungathe kuzichita.

Ndikotheka kukhala ndi moyo ndi matenda ashuga amtundu woyamba ndikuchira matenda amtundu wa 2, koma izi zimafunikira kuyitsirana ndi chitsulo. Nokha, matenda abwinobwino a amayi oyembekezera okha ndi omwe adzadutsa, koma ndi chifukwa chodera nkhawa za chitukuko, pakapita nthawi, cha T2DM.

Chifukwa chiyani ndikofunikira kuti odwala matenda ashuga azitsatira osati zakudya zokha, koma mitundu yaying'ono yamoto, komanso azimayi achichepere omwe adayamwa matenda a shuga kuti akhalepo ndikumwa yoyamwitsa, vidiyoyi ikufotokozera.

Insulin Lantus ndi mankhwala omwe amachepetsa shuga m'thupi. Chothandizira chophatikizika ndi insulin glargine. Uku ndi kuwonetsera kwa insulin yaumunthu, yomwe singasungunuke bwino m'malo osalowerera ndale. M'mafakisoni mutha kuwona mitundu itatu ya kutulutsidwa kwa mankhwalawa: cholembera cha sytinge ya OptiSet, machitidwe a OptiClick ndi Lantus SoloStar. Kodi kugwiritsa ntchito mankhwalawa ndi ziti?

Insulin Lantus imakhala ndi mphamvu yayitali, imapangitsa kagayidwe ka glucose ndikuwongolera kagayidwe kazakudya. Mukamamwa mankhwalawa, shuga wambiri ndi minofu ndi minofu yamafuta imathandizidwa. Komanso, wothandizirana ndi mahomoni amathandizira kupanga mapuloteni. Nthawi yomweyo, proteinolysis ndi lipolysis mu adipocytes ndizoletsa.

Contraindication

Contraindicated vuto la tsankho kwa yogwira mankhwala kapena othandizira zigawo. Kwa achinyamata, mankhwalawa amalembedwa pokhapokha ali ndi zaka 16.

Kusamalidwa kwapadera kuyenera kuchitika mukamapanga proliferative retinopathy, kuchepetsedwa kwa ziwalo zamkati ndi ziwalo. Kuyang'ana kuchipatala kumafunikanso kwa odwala omwe ali ndi zobisika za hypoglycemia. Matendawa amatha kufinya matendawa ndimatenda amisala, malingaliro osatha a matenda a shuga.

Malinga ndi ziwonetsero zovuta, zimaperekedwa kwa odwala okalamba. Zomwezi zikugwiranso ntchito kwa anthu omwe asintha kuchokera ku insulin yakuchokera kwa nyama kupita kwa munthu.

Kodi nditha kubayitsa usiku Lantus komanso nthawi yomweyo ultrashort insulin musanadye?

Mwauli, mutha kutero.Komabe, ngati mukukumana ndi vuto la shuga m'mimba pamimba yopanda kanthu, ndikofunikira kuti mupeze Lantus usiku mochedwa momwe mungathere musanagone. Insulin yachangu musanadye chakudya chamadzulo, mudzafunika kulowa maora angapo m'mbuyomu.

Ndikofunikira kuti mumvetsetse cholinga cha jakisoni iliyonse yomwe yatchulidwa mufunso. Muyenera kuthandizanso kusankha molondola kuchuluka kwa insulin yokonzekera mwachangu komanso yayitali. Werengani nkhaniyo "" kuti mumve zambiri pazokambirana zazifupi ndi za ultrashort.

Lantus wa matenda ashuga amtundu wa 2

Lantus akhoza kukhala mankhwala omwe insulin yothandizira mtundu wa matenda a shuga 2 imayamba nawo. Choyamba, amasankha jakisoni wa insulin iyi usiku, kenako m'mawa. Ngati shuga akupitiliza kudya mutatha kudya, mankhwala ena aafupi kapena a ultrashort amawonjezeredwa ku regulin ya insulin - Actrapid, Humalog, NovoRapid kapena Apidra.

Dr. Bernstein akulangizani kuti muthane ndi jekeseni watsiku ndi tsiku jakisoni - madzulo ndi m'mawa. Ngakhale kuti kuchuluka kwa jakisoni sikungachepe, kusinthira ku Tresib insulin kumathandizabe. Chifukwa shuga wamagazi azikhala bwino. Adzakhala khola.

Ndi insulin iti yomwe ili bwino: Lantus kapena Tujeo? Kodi pali kusiyana kotani pakati pa awiriwa?

Ili ndi zinthu zomwezi monga Lantus - insulin glargine. Komabe, kuchuluka kwa insulini mu yankho la Tujeo ndi katatu maulendo - 300 IU / ml. Mwakutero, mutha kupulumutsa pang'ono ngati mupita ku Tujeo. Komabe, ndibwino kusatero. Kuwona za matenda ashuga okhudza insulin ya Tujeo ndizovuta zambiri. Mwa odwala ena, atasintha kuchoka ku Lantus kupita ku Tujeo, shuga ammwazi amalumpha, mwa ena, pazifukwa zina, insulin yatsopano mwadzidzidzi imasiya kugwira ntchito. Chifukwa chokhala ndi chidwi chambiri, nthawi zambiri imakulira ndikuphimba singano ya cholembera. Tujeo mokalipa sanakalipira kunyumba zokha, komanso m'mabizinesi a shuga a Chingerezi. Chifukwa chake, ngati kuli kotheka, ndibwino kupitilizabe kupha Lantus osasintha. Ndikofunika kusinthira pazifukwa zomwe tafotokozazi.

Ndi insulin iti yomwe ili bwino: Lantus kapena Levemir?

Asanayambike insulin, Dr. Bernstein adagwiritsa ntchito kwazaka zambiri, osati Lantus. Mu 1990s, zolemba zingapo zidawonekera, ndikuti Lantus imawonjezera chiopsezo cha mitundu ina ya khansa. adatenga malingaliro awo mozama, adasiya kubayiranso insulin glargin kwa iye ndikuwapatsa mankhwala. Kampani yopanga idayamba kukangana - ndipo mchaka cha 2000 panali zolemba zambiri zonena kuti mankhwala a Lantus ndi otetezeka. Kwambiri, ngakhale insulin glargine imawonjezera chiopsezo cha mitundu ina ya khansa, ndiye pang'ono. Izi siziyenera kukhala chifukwa chopita ku Levemire.

Ngati mungalowe mu Lantus ndi Levemir muyezo womwewo, ndiye kuti jekeseni wa Levemir atha pang'ono pang'ono. Iwo amavomerezeka jekeseni wa Lantus kamodzi patsiku, ndipo Levemir - 1 kapena 2 kawiri pa tsiku. Komabe, pochita, mankhwalawa onse amafunika kubayidwa katatu patsiku, m'mawa ndi madzulo. Jakisoni imodzi patsiku sikokwanira. Kutsiliza: ngati Lantus kapena Levemir akuyenera kukhala bwino, pitilizani kugwiritsa ntchito. Kusintha kupita ku Levemir kuyenera kuchitika pokhapokha pakufunika. Mwachitsanzo, ngati mtundu wina wa insulini umayambitsa ziwengo kapena samaperekanso kwaulere. Komabe, iyi ndi nkhani inanso. Amachita bwino koposa. Ndikofunika kusinthira ngati mtengo wokwera suuletsa.

Odwala ayenera kudziwitsa dokotala za mimba yomwe ilipo kapena yakonzekera.

Panalibe mayesero azachipatala omwe amayesedwa mwachisawawa pakugwiritsa ntchito insulin glargine mwa amayi apakati.

Chiwerengero chochulukirapo (zotsatira zopitilira 1000 za kubereka poyeserera komanso kuyembekezera kutsata) ndi malonda atagulitsa insulin glargine adawonetsa kuti sanakhale ndi zotsatirapo zake pamaphunziro ndi zotsatira za kubereka kapena mkhalidwe wakakhanda, kapena thanzi la mwana wakhanda.

Kuphatikiza apo, pofuna kuyesa chitetezo cha insulin glargine ndi insulin-isophan ntchito kwa amayi apakati omwe ali ndi matenda am'mbuyomu kapena a gestational matenda osokoneza bongo, kuwunika kwa meta-kuyesedwa kwa mayesero asanu ndi atatu a kuchipatala kunachitika, kuphatikiza azimayi omwe adagwiritsa ntchito insulin glargine pa nthawi yoyembekezera (n = 331) ndi insulin isophane (n = 371).

Kuunika kwa meta kumeneku sikunawonetse kusiyana kwakukulu pokhudza chitetezo cha mayi kapena mwana wakhanda pogwiritsa ntchito insulin glargine ndi insulin-isophan panthawi yapakati.

Kwa odwala omwe ali ndi matenda osokoneza bongo omwe alipo kale kapena a gestational matenda a shuga, ndikofunikira kuti azitha kuyang'anira machitidwe a metabolic panthawi yonse yoletsa kupewa kupezeka kwa zotsatira zosakhudzana ndi hyperglycemia.

Mankhwala Lantus® SoloStar® angagwiritsidwe ntchito pa nthawi ya pakati pazifukwa zamankhwala.

Kufunika kwa insulin kumatha kuchepa mu trimester yoyamba ya kutenga pakati, komanso, kuwonjezeka panthawi yachiwiri komanso yachitatu.

Pambuyo pobadwa, kufunika kwa insulini kumachepera msanga (chiopsezo cha hypoglycemia chikuwonjezeka). Pansi pa izi, kuwunikira mosamala kuchuluka kwa shuga m'magazi ndikofunikira.

Odwala pa mkaka wa m`mawere angafunikire kusintha Mlingo wa insulin ndi zakudya.

M'maphunziro a zinyama, palibe deta yachindunji kapena yosalunjika yomwe idapezeka pa embryotoxic kapena fetotoxic zotsatira za insulin glargine.

Mpaka pano, palibe ziwerengero zoyenera zogwiritsira ntchito mankhwalawa panthawi yapakati. Pali umboni wa kugwiritsa ntchito kwa Lantus mwa azimayi 100 oyembekezera omwe ali ndi matenda ashuga. Maphunziridwe ake ndi zotsatira za kutenga pakati pa odwalawa sizinasiyanane ndi zomwe zimachitika mwa amayi apakati omwe ali ndi matenda ashuga omwe amalandiranso kukonzekera kwina kwa insulin.

Kukhazikitsidwa kwa Lantus mwa amayi apakati kuyenera kuchitika mosamala. Kwa odwala omwe ali ndi matenda osokoneza bongo omwe alipo kale kapena a gestationalabetes mellitus, ndikofunikira kuti azitha kuyang'anira machitidwe a metabolic panthawi yonse yovomerezeka.

Kufunika kwa insulin kumatha kuchepa mu trimester yoyamba ya kutenga pakati ndikuwonjezeka panthawi yachiwiri komanso yachitatu. Pambuyo pobadwa, kufunika kwa insulini kumachepera msanga (chiopsezo cha hypoglycemia chikuwonjezeka).

Pansi pa izi, kuyang'anira shuga wamagazi ndikofunikira.

Mwa kuyamwa azimayi, mlingo wa insulini komanso kusintha kwa zakudya kungafunike.

Zotsatira zoyipa za mankhwalawa pa thupi la amayi apakati komanso mwana wosabadwa sizitsimikiziridwa ndi maphunziro azachipatala. Komabe, azimayi omwe ali ndi pakati pa nthawi yobereka ayenera kumwa mankhwalawa mosamala kwambiri, ndikuyang'anira mosamala madokotala omwe akupita.

Ngakhale akumamwa mankhwalawa, amayi apakati amafunika kuyesa magazi pafupipafupi kuti awone kuchuluka kwa shuga mthupi. Miyezi itatu yoyambirira ya kubereka, kufunikira kwa insulin kumatha kuchepetsedwa, koma mu 2nd ndi 3 trimester imatha kuchuluka. Pambuyo pobadwa kwa mwana, kufunikira kwa mankhwalawa kumacheperanso, komwe kumalumikizidwa ndi kusintha kwa mahomoni.

Insulin Yaitali - Zida za Chithandizo cha Matenda A shuga

Ndi matendawa, matenda a shuga amafunikira chithandizo cha insulin. Insulin yochepa ndi insulin yayitali imagwiritsidwa ntchito pochiza matendawa. Moyo wamunthu wodwala matenda ashuga kwambiri umatengera kutsatira malangizo onse azachipatala.

Insulin yowonjezereka yogwira mtima imafunikira pamene kusala kudya kwa shuga m'magazi kumafunikira kusintha. Ma insulin omwe amakhala nthawi yayitali kwambiri ndi Levemir ndi Lantus, omwe wodwalayo amayenera kuperekedwa kamodzi pa maola 12 kapena 24.

Insulin yayitali imakhala ndi katundu wodabwitsa, imatha kutsanzira mahomoni achilengedwe omwe amapangidwa ndi maselo a kapamba.Nthawi yomweyo, amakhala ofatsa pamaselo oterowo, amathandizira kuchira, komwe mtsogolo limalola kukana insulin.

Jekeseni wa insulin wa nthawi yayitali ayenera kuperekedwa kwa odwala omwe ali ndi shuga wambiri masana, koma akuyenera kuwonetsetsa kuti wodwalayo amadya chakudya pasanathe maola 5 asanagone. Komanso, insulin yayitali imapangidwira chizindikiro cha "m'mawa kutacha", maselo a chiwindi akayamba usiku wodwalayo asanadzuke, asokoneze insulin.

Ngati insulin yayifupi imafunikira jekeseni masana kuti muchepetse shuga omwe amaperekedwa ndi chakudya, ndiye kuti insulin yayitali imatsimikizira maziko a insulini, imathandizira kupewa ketoacidosis, komanso imathandizanso kubwezeretsa maselo a pancreatic beta.

Jekeseni wa insulin yochulukirapo imayenera kuthandizidwa kale chifukwa imathandizira wodwalayo kuonetsetsa kuti matenda amtundu wachiwiri samapitilira mtundu woyamba wa matenda.

Kuwerengera molondola kwa mlingo wa insulin yayitali usiku

Kuti mukhale ndi moyo wabwinobwino, wodwalayo ayenera kuphunzira momwe angawerengere molondola kuchuluka kwa Lantus, Protafan kapena Levemir usiku, kotero kuti msanga wama glucose amasungidwa pa 4.6 ± 0.6 mmol / l.

Kuti muchite izi, mkati mwa sabata muyenera kuyeza kuchuluka kwa shuga usiku ndi m'mawa pamimba yopanda kanthu. Kenako muyenera kuwerengera mtengo wa shuga m'mamawa mtengo wake wa dzulo usiku ndikuwerengera kuchuluka, izi zikuwonetsa chisonyezo chochepa chofunikira.

Mwachitsanzo, ngati kuchuluka kwochepa kwa shuga ndi 4.0 mmol / l, ndiye kuti gawo limodzi la insulin yayitali ingachepetse chizindikirocho ndi 2.2 mmol / l mwa munthu wolemera makilogalamu 64. Ngati kulemera kwanu ndi makilogalamu 80, ndiye kuti timagwiritsa ntchito njira zotsatirazi: 2.2 mmol / L * 64 kg / 80 kg = 1.76 mmol / L.

Mlingo wa insulin kwa munthu wolemera makilogalamu 80 uyenera kukhala magawo 1.13, chiwerengerochi chimakhala chozungulira kufika kotala ndipo timalandira 1.25E.

Tiyenera kudziwa kuti Lantus sangathe kuchepetsedwa, chifukwa chake imafunikira kubayidwa ndi 1ED kapena 1,5ED, koma Levemir imatha kuchepetsedwa ndikuvulaza ndi mtengo wofunikira. M'masiku otsatirawa, muyenera kuwunika momwe shuga angakhalire kudya ndikuwonjezera kapena kuchepetsa kuchuluka kwake.

Amasankhidwa moyenera komanso molondola ngati, mkati mwa sabata, shuga osala kudya saposa 0.6 mmol / l, ngati mtengo wake umakhala wokwera, ndiye yesani kuwonjezera kuchuluka kwa mankhwala ndi mayunitsi a 0.25 masiku atatu aliwonse.

Momwe mungagwiritsire ntchito mankhwala

Mankhwala amagwiritsidwa ntchito pa matenda a shuga, omwe amafunikira chithandizo ndi insulin. Nthawi zambiri imakhala mtundu woyamba wa shuga. Hormoni imatha kutumizidwa kwa odwala onse azaka zopitilira zisanu ndi chimodzi.

Kuchita insulin kwa nthawi yayitali ndikofunikira kuti magazi a wodwalayo azisala mwachangu. Munthu wathanzi m'magazi nthawi zonse amakhala ndi kuchuluka kwa mahomoni awa, zomwe zimakhala m'magazi zimatchedwa basal level.

Odwala omwe ali ndi matenda a shuga mellitus ngati ali ndi vuto la kapamba, pakufunika insulin, yomwe imayenera kuperekedwa nthawi zonse.

Njira ina yotulutsira mahomoni m'magazi imatchedwa bolus. Zimaphatikizidwa ndi kudya - poyankha kuwonjezeka kwa shuga wamagazi, insulini ina imatulutsidwa kuti mwachangu matenda a glycemia ayambe kudwala.

Mu shuga mellitus, ma insulin osakhalitsa amagwiritsidwa ntchito pamenepa. Pankhaniyi, wodwalayo amayenera kudziphatikiza ndi cholembera nthawi iliyonse atatha kudya, zomwe zimakhala ndi kuchuluka kwa mahomoni.

M'mafakitala, kuchuluka kwa mitundu yosiyanasiyana ya mankhwala othandizira matenda a shuga amagulitsidwa. Ngati wodwala akufunika kugwiritsa ntchito timadzi tambiri tomwe timapanga, ndiye kuti ndi bwino kugwiritsa ntchito - Lantus kapena Levemir? Munjira zambiri, mankhwalawa ndi ofanana - onse ndi ofunika, ndi olosera kwambiri komanso osasunthika pakugwiritsa ntchito.

Tiyeni tiwone momwe mahomoni awa amasiyanirana.Amakhulupilira kuti Levemir ali ndi moyo wautali kwambiri kuposa Lantus Solostar - mpaka masabata 6 motsutsana ndi mwezi umodzi. Chifukwa chake, Levemir amadziwika kuti ndiwothandiza kwambiri ngati mukufunikira kuti mupeze mankhwala ochepa, mwachitsanzo, kutsatira zakudya zamafuta ochepa.

Akatswiri akuti Lantus Solostar angakulitse chiopsezo cha khansa, koma palibe chodalirika pazomwezi.

Glargin ndi mankhwala ena

Kuphatikiza ndi mankhwala ena kumakhudza kagayidwe kachakudya kamene kamayenderana ndi shuga:

1. Mankhwala ena amalimbikitsa mphamvu ya Lantus. Izi zikuphatikiza ndi sulfonamides, salicylates, mankhwala ochepetsa mphamvu ya glucose, ACE ndi mao inhibitors.
2. Ma diuretics, sympathomimetics, proteinase inhibitors, antipsychotic amodzi, mahomoni - akazi, chithokomiro, etc. zimafooketsa zotsatira za insulin glargine.
3. Zakudya zamafuta a lithiamu, ma beta-blockers kapena kumwa mowa zimayambitsa zovuta - kuwonjezera kapena kufooketsa mphamvu ya mankhwalawa.
4. Kutenga pentamidine mogwirizana ndi Lantus kumabweretsa spikes m'magulu a shuga, kusintha kwakuthwa kuchokera pakuchepa kupita pakuwonjezeka.

Mwambiri, mankhwalawa amakhala ndi ndemanga zabwino. Kodi glulin ya insulin imawononga ndalama zingati? Mtengo wa ndalama m'magawo umachokera ku ruble 2500-4000.

Tisanthula momwe tingagwiritsire ntchito Lantus - malangizo oti agwiritse ntchito akuti ayenera kulowetsedwa mosavomerezeka m'matumbo a mafuta pakhoma lakumbuyo, ndipo sangathe kugwiritsidwa ntchito kudzera m'mitsempha. Njira iyi yogwiritsira ntchito mankhwalawa idzatsogolera kutsika kwakukulu kwamagazi a glucose ndikukula kwa chikumbumtima cha hypoglycemic.

Kuphatikiza pa CHIKWANGWANI pamimba, pali malo ena oyambitsira a Lantus - minofu yachikazi, yachikazi. Kusintha kwake muzochitika izi ndizosafunikira kapena kulibe.

Homoni sangaphatikizidwe pamodzi ndi mankhwala ena a insulin, sangathe kuchepetsedwa musanagwiritse ntchito, chifukwa izi zimachepetsa mphamvu yake. Ngati mumasakanikirana ndi zinthu zina zamankhwala am'madzi, mpweya wabwino ndiwotheka.

Kuti muchite bwino pochiritsa, Lantus iyenera kugwiritsidwa ntchito mosalekeza, tsiku lililonse pafupifupi nthawi yomweyo.

Ndi mtundu wanji wa insulini yomwe muyenera kugwiritsira ntchito matenda ashuga, endocrinologist angakulangizeni. Nthawi zina, mankhwalawa amagwiritsidwa ntchito mwachisawawa; nthawi zina pamafunika kuphatikiza ma insulin omwe amakhala nthawi yayitali komanso amakhala nthawi yayitali. Chitsanzo cha kuphatikiza kotere ndi kugwiritsidwa ntchito palimodzi kwa Lantus ndi Apidra, kapena kuphatikiza monga Lantus ndi Novorapid.

Muzochitika izi, pazifukwa zina, zimayenera kusintha mankhwalawa Lantus Solostar kupita kwina (mwachitsanzo, kupita ku Tujeo), malamulo ena ayenera kuwonedwa. Chofunika kwambiri, kusinthaku sikuyenera kumayenderana ndi kupsinjika kwakukulu kwa thupi, kotero simungathe kutsitsa mlingo wa mankhwalawa malinga ndi kuchuluka kwa magawo anu.

M'malo mwake, m'masiku oyamba kukonzekera, kuwonjezeka kwa insulini komwe kumayendetsedwa kuti mupewe hyperglycemia. Magulu onse amthupi atayamba kugwiritsa ntchito bwino mankhwala, mutha kuchepetsa mankhwalawo kuti akhale olondola.

Zosintha zonse munthawi ya mankhwala, makamaka zokhudzana ndi kusintha kwa mankhwalawo ndi ma analogues, ziyenera kuvomerezedwa ndi dokotala, yemwe amadziwa momwe mankhwala amasiyana ndi omwe amathandizanso.

Kufunika kogwiritsa ntchito magulu ena a mankhwalawa kuyenera kudziwitsidwa kwa adokotala. Mankhwala ena, omwe amagwiritsidwa ntchito ndi Lantus, amalimbikitsa zotsatira zake, pomwe ena, m'malo mwake, amawaletsa, ndikupangitsa kuti pakhale zovuta kulandira chithandizo chokwanira.

Mankhwala omwe amathandizira Lantus:

• zoletsa
• antimicrobial othandizira
• gulu lama salicylates, ma fibrate,
• Fluoxetine.

Kukhazikitsa kwawo munthawi yomweyo kungayambitse kudumphadumpha mu shuga komanso kuthamanga kwambiri kwa glycemia. Ngati sizotheka kuletsa ndalama izi, ndikofunikira kusintha mlingo wa insulin.

Kuchepa mphamvu kwa mankhwalawa kumatha kuchitika mukamayanjana ndi mankhwala okodzetsa, gulu la estrogens ndi progestogens, atpsical antipsychotic. Mankhwala a Hormonal omwe cholinga chake ndi kuchiritsa matenda a chithokomiro ndi endocrine amatha kufooketsa mphamvu ya hypoglycemic ya Lantus.

Ndikulimbikitsidwa kwambiri kuti musamwe zakumwa zoledzeretsa ndikugwiritsira ntchito mankhwala a gulu la beta-blocker pochiza, zomwe zimachepetsa mphamvu ya mankhwalawa ndikuwonjezera glycemia, kutengera mlingo ndi momwe wodwalayo alili.

Kuchita mankhwala osokoneza bongo ndi mankhwala angapo kungakhudze kagayidwe ka glucose. Mankhwala otsatirawa amakhudza zochita za Lantus malinga ndi malangizo:

• Mankhwala osokoneza bongo omwe amathandizira Lantus (insulin glargine) - zoletsa za ACE, mankhwala osokoneza bongo a hypoglycemic, mao inhibitors, fluoxetine, fibrate, disopyramides, propoxyphene, pentoxifylline, mankhwala a sulfonamide ndi salicylates.
• Mankhwala osokoneza bongo omwe amachepetsa mphamvu ya Lantus (insulin glargine) - GCS, diazoxide, danazole, diuretics, gestagens, estrogens, glucagon, isoniazid, somatotropin, phenothiazine zotumphukira, sympathomimetics (epinephrine, terbutaline, salbutaminapaseazeputapulazeputapulatapulatapulataputazigulatapulazigatapulatapulataputaziguligatapodataput hape. mahomoni a chithokomiro
• Zonsezi zimathandizira ndikuchepetsa mphamvu ya Lantus (insulin glargine) beta-blockers, mchere wa lithiamu, clonidine, mowa,
• Kusakhazikika kwa kuchuluka kwa shuga m'magazi ndikusintha kwa hypoglycemia kupita ku hyperglycemia kungayambitse nthawi yayitali ya Lantus ndi pentamidine,
• Zizindikiro za kukakamiza kwa adrenergic zitha kuchepetsedwa kapena kusakhalapo mukamamwa mankhwalawa achifundo - guanfacin, clonidine, reserpine ndi beta-blockers.

Mlingo ndi makonzedwe

Lantus® ili ndi insulin glargine - analog ya insulin yokhala ndi nthawi yayitali. Lantus® iyenera kugwiritsidwa ntchito kamodzi patsiku, nthawi iliyonse patsiku, koma nthawi yomweyo, tsiku lililonse.

Mlingo (Mlingo ndi nthawi ya makonzedwe) wa Lantus ayenera kusankhidwa payekhapayekha. Kwa odwala omwe ali ndi matenda a shuga a mtundu wa 2, Lantus® itha kugwiritsidwanso ntchito ndi mankhwala apakamwa.

Zochita za mankhwalawa zimafotokozedwanso m'mayunitsi. Magawo awa ndi a Lantus okha ndipo safanana ndi INE ndipo magawo omwe amagwiritsidwa ntchito kufotokoza mphamvu za zochita za ma insulin ena (onani. Pharmacodynamics).

Okalamba okalamba (≥ zaka 65)

Mwa odwala okalamba, kuchepa kwapang'onopang'ono kwaimpso kungayambitse kuchepa kwamphamvu kwa insulin.

Matenda aimpso

Odwala omwe ali ndi vuto laimpso, insulin ingafune kuchepa chifukwa cha kuchepa kwa insulin.

Kuchepa kwa chiwindi ntchito

Odwala omwe ali ndi vuto la chiwindi, vuto la insulin lingathe kuchepa chifukwa cha kuchepetsedwa kwa gluconeogeneis komanso kuchepa kwa insulin.

Kutetezeka ndi kugwiritsa ntchito mankhwalawa Lantus® kwatsimikiziridwa mu achinyamata ndi ana azaka 2 ndi akulu (onani "Pharmacodynamics"). Lantus® sanaphunzitsidwe mwa ana osakwana zaka 2.

Kusintha kuchokera ku insulin ina kupita ku Lantus®

Posintha njira yochizira ndi insulin ya nthawi yayitali kapena insulin yokhala ndi mankhwala a Lantus, pangafunike kusintha mlingo wa insal insulin ndikusintha chithandizo cha antidiabetesic nthawi yomweyo (Mlingo ndi nthawi ya makonzedwe owonjezera osakanikirana a insulin kapena maulalo anthawi ya mankhwala a insulin. ndalama).

Kuchepetsa chiwopsezo cha usiku kapena m'mawa kwambiri hypoglycemia, odwala omwe amasintha kuchokera ku regimen iwiri ya insal NPH kupita ku regimen imodzi ndi Lantus ayenera kuchepetsa mlingo wawo wa tsiku ndi tsiku wa 205 wa insulin ndi 20-30% m'milungu yoyamba yamankhwala.

M'masabata oyamba, kuchepetsa kwa mankhwalawa kuyenera kulipiriridwa pang'ono pakukweza mlingo wa insulin womwe umagwiritsidwa ntchito pakudya, nthawi imeneyi, mankhwalawa amayenera kusinthidwa payekhapayekha.

Monga ma enulin ena, mwa odwala omwe amalandira Mlingo wambiri wa insulin chifukwa cha kupezeka kwa ma antibodies a insulin ya anthu, ndizotheka kusintha mayankho a insulin panthawi ya mankhwala a Lantus.

Panthawi yosinthira ku Lantus® komanso milungu yoyamba itatha, kuwunikira mosamala zizindikiro za metabolic kumafunika.

Momwe ma metabolic control amayenda bwino, ndipo chifukwa chake, chidwi cha minofu pakuwonjezereka kwa insulin, kusintha kwina kwa mankhwala kungafunikire. Kusintha kwa magazi kungafunikenso, mwachitsanzo, ndikusintha kwa thupi kapena momwe wodwalayo asinthira, kusintha kwa nthawi ya insulin komanso zina, zomwe zikubwera kumene zomwe zikuwonjezera kutsimikiza kwa hypoglycemia kapena hyperglycemia (onani "Malangizo apadera").

Lantus® iyenera kuyendetsedwa mosakakamiza. Lantus® sayenera kutumikiridwa kudzera m'mitsempha. Kuchita kwa nthawi yayitali kwa Lantus kumachitika chifukwa cha kuyambitsidwa kwake pamafuta obisika. Mitsempha yodziwika yokhazikika ya subcutaneous mlingo ungayambitse kwambiri hypoglycemia. Palibenso kusiyana kwakukulu pakumveka kwa seramu insulini kapena shuga pambuyo poyambika kwa Lantus kupita khoma lam'mimba, minofu yolimba, kapena ntchafu. Ndikofunikira kusintha malo a jekeseni mkati mwa malo omwewo nthawi iliyonse. Lantus® sayenera kusakanikirana ndi insulin ina kapena kuchepetsedwa. Kusakanikirana ndikusintha kungasinthe nthawi / zochita; Kuti mupeze malangizo mwatsatanetsatane wokhudza mankhwalawa, onani pansipa.

Malangizo apadera ogwiritsa ntchito

Ma cartridge a Lantus ® azigwiritsidwa ntchito kokha ndi OptiPen®, ClickSTAR®, Autopen® 24 hand (onani "Maupangiri Apadera").

Malangizo a wopanga kuti azigwira cholembera zodulira katiriji, ma nozzles, komanso kayendetsedwe ka insulin ziyenera kuyang'aniridwa bwino.

Ngati cholembera cha insulin chawonongeka kapena chasokonekera (chifukwa cha kuwonongeka kwa makina), iyenera kutayidwa ndipo cholembera chatsopano cha insulin chikuyenera kugwiritsidwa ntchito.

Ngati cholembera sichikuyenda bwino (onani malangizo okhudza cholembera), ndiye kuti yankho limatha kuchotsedwa mu katoni ndikulowetsa sindolo (yoyenera ma insulin 100 ml / ml) ndikujowina.

Asanalowetse cholembera, cartridge iyenera kusungidwa kwa maola 1-2 kutentha kwa firiji.

Yenderani cartridge musanagwiritse ntchito. Itha kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lopanda mawonekedwe olimba komanso lokhazikika. Popeza Lantus® ndi yankho, sizifunikira kupumulanso musanagwiritse ntchito.

Lantus® sayenera kusakanikirana ndi insulin ina kapena kuchepetsedwa. Kusakaniza kapena kuchepetsa kungasinthe mawonekedwe ake / mawonekedwe;

Mafuta opakidwa mpweya ayenera kuchotsedwa pagolosale asanalowe jakisoni (onani malangizo a chogwirira). Makatoni opanda kanthu sangakwaniritsidwe.

Zolembera ziyenera kugwiritsidwa ntchito ndi ma cartantges a Lantus®. Ma cartridge a Lantus® ayenera kugwiritsidwa ntchito pokhapokha ndi zolembera zotsatirazi: OptiPen®, ClickSTAR® ndi Autopen® 24, siziyenera kugwiritsidwa ntchito ndi zolembera zina zongobwezeretsanso, popeza kulondola kwa dosing ndikodalirika kokha ndi zolembera.

Yang'anani vial musanagwiritse ntchito. Itha kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lopanda mawonekedwe olimba komanso lokhazikika. Popeza Lantus® ndi yankho, sizifunikira kupumulanso musanagwiritse ntchito.

Lantus® sayenera kusakanikirana ndi insulin ina kapena kuchepetsedwa. Kusakaniza kapena kuchepetsa kungasinthe nthawi yake / zochita; kusakaniza kumatha kubweretsa mpweya.

Ndikofunikira nthawi zonse kuyika chizindikiro pa insulin musanadye jekeseni iliyonse, kuti musasokoneze insulin glargine ndi ma insulin ena (onani "Maupangiri Apadera").

Makulidwe olakwika a mankhwalawa

Milandu yanenedwa pomwe mankhwalawo amasakanikirana ndi ma insulin ena, makamaka, ma insulin omwe amangogwiritsa ntchito mwachidule anali kuyendetsedwa m'malo mwa glargine molakwika. Pamaso jekeseni aliyense, ndikofunikira kuyang'ana chizindikiro cha insulin kuti mupewe chisokonezo pakati pa insulin glargine ndi ma insulin ena.

Kuphatikiza kwa Lantus ndi pioglitazone

Milandu yakulephera kwa mtima imadziwika pamene pioglitazone imagwiritsidwa ntchito limodzi ndi insulin, makamaka kwa odwala omwe ali ndi chiopsezo cha mtima. Izi ziyenera kukumbukiridwa popereka kaphatikizidwe ka pioglitazone ndi Lantus. Ngati chithandizo chophatikizidwa chalamulidwa, odwala ayenera kuwunikidwa kuti awone zizindikiro ndi chizindikiro cha kulephera kwa mtima, kunenepa kwambiri, ndi kutupa. Pioglitazone iyenera kusiyidwa ngati chizindikiro chilichonse chamtima chikaipiraipira.

Mankhwalawa sangaphatikizidwe ndi mankhwala ena. Ndikofunikira kuti ma syringe asakhale ndi zinthu zina.

Zotsatira zoyipa

Hypoglycemia, njira yovuta kwambiri yogwiritsira ntchito mankhwala a insulin, imatha kukhala ngati mlingo wa insulin ndiwokwera kwambiri poyerekeza ndi kufunika kwa insulin, zochitika zazikulu za hypoglycemia, makamaka zobwerezabwereza, zitha kuwononga dongosolo lamanjenje. Kugwedezeka kwa nthawi yayitali kapena kupweteka kwambiri kwa hypoglycemia kukhoza kumuvulaza. Odwala ambiri, Zizindikiro za neuroglycopenia zimayambitsidwa ndi zizindikiritso za adrenergic. Mokulira, kuchuluka kwa glucose m'magazi kumacheperachepera, kumamvekera kwambiri ndi zomwe zimachitika pokana kutsutsana ndi zomwe zimachitika.

Zochita zamankhwala osokoneza bongo

Zinthu zingapo zimakhudza kagayidwe ka glucose ndipo zimapangitsa kusintha kwa insulin glargine.

Zinthu zomwe zimathandizira kuchepetsa kutsika kwa glucose m'magazi ndikuwonjezera chiwopsezo cha hypoglycemia zimaphatikizira antidiabetesic agents, angiotensin-akatembenuka enzyme inhibitors (ACEs), disopyramides, fibrate, fluoxetine, monoamine oxidase inhibitors (MAOs), pentoxifylilides ndi pentoxifylilides.

Zinthu zomwe zitha kufooketsa mphamvu ya shuga m'magazi zimaphatikizira mahomoni a corticosteroid, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens ndi progestogens, zotuluka za phenothiazine, somatropin, sympathomimetics (mwachitsanzo, epinephrine (adrenbutine) , mankhwala a atypical antipsychotic (mwachitsanzo, clozapine ndi olanzapine) ndi ma proteinase inhibitors.

Beta-blockers, clonidine, mchere wa lithiamu ndi mowa zimatha kutsitsa ndikuchepetsa mphamvu ya insulin m'magazi. Pentamidine imatha kuyambitsa hypoglycemia, ndipo nthawi zina imatsatiridwa ndi hyperglycemia.

Kuphatikiza apo, mothandizidwa ndi mankhwala achifundo monga β-blockers, clonidine, guanethidine ndi reserpine, zizindikiro za kutsutsa kwa adrenergic zitha kukhala zofatsa kapena kusapezeka.

Mimba

Amayi oyembekezera pokhapokha pakufunika. Ndikofunika kuyang'anitsitsa kuchuluka kwa shuga m'magazi ndikuwunika momwe mayi wapakati amakhalira. M'miyezi itatu yoyambirira, kufunikira kwa insulin kumachepa, ndipo miyezi isanu ndi umodzi yotsatira imadzuka. Mukangopereka kumene, kufunika kwa chinthu ichi kumatsika kwambiri. Pali chiopsezo cha hypoglycemia.

Ndi mkaka wa m`mawere, kumwa mankhwala n`zotheka, koma mosamala kuwunika. Glargin imalowetsedwa m'matumbo am'mimba ndikugawika ma amino acid. Zilibe kuvulaza mwana poyamwitsa.

Kusintha kupita ku Lantus kuchokera ku mitundu ina ya insulin

Ngati wodwalayo adamwa kale mankhwala osokoneza bongo nthawi yayitali komanso pakati, ndiye kuti mukusintha kupita ku Lantus, kusintha kwa insulin yayikulu ndikofunikira. Thercomitant tiba iyeneranso kuwunikiridwa.

Pamene majakisoni awiri a basal insulin (NPH) asinthidwa kukhala jakisoni imodzi ya Lantus, mlingo woyamba umatsika ndi 20-30%. Izi zimachitika masiku 20 oyambirira a mankhwala. Izi zikuthandizira kupewa hypoglycemia usiku ndi m'mawa. Pankhaniyi, mlingo womwe umaperekedwa musanadye chakudya umakulitsidwa. Pambuyo pa masabata 2-3, kukonza kwa kuchuluka kwa zinthu kumachitika palokha kwa wodwala aliyense.

Mthupi la odwala ena, ma antibodies a insulin yaumunthu amapangidwa. Pankhaniyi, mayankho omenyera chitetezo ku majakisidwe a Lantus amasintha. Kungafunikenso kuunikiridwa mlingo.

Kuchita ndi mankhwala ena

Mankhwala osiyanasiyana amatha kuonjezera mphamvu ya hypoglycemic ya Lantus ndikuchepetsa. Gulu loyamba limaphatikizira mankhwala a hypoglycemic a pakamwa, disopyramide, salicylates, propoxyphene, fluoxetine, sulfonamide antimicrobials, monoamine oxidase inhibitors, fibrate ndi pentoxifylline.

Zofooka zomwe zimapangidwira zimaperekedwa ndi danazole, kulera kwa mahomoni, ma diuretics, glucagon, isoniazid, proteinase inhibitors, epinephrine, kukula kwa mahomoni, salbutamol, phenothiazine, terbutaline, antipsychotic, mahomoni a chithokomiro.

Zinthu zina zimakhala ndi mphamvu pawiri pa hypoglycemic katundu wa glargine. Izi zimaphatikizapo pentamidine, beta-blockers, mchere wa lithiamu, clonidine, mowa, guanethidine, reserpine. Awiri omaliza mafuta ophikira a hypoglycemia yomwe ili pafupi.

Lantus ndi imodzi mwazithunzi zopanda pake za insulin ya munthu. Kupezeka m'malo mwa amino acid katsitsumzukwa ndi glycine pa 21 malo A ndi unyolo ndikuwonjezera awiri arginine amino acid mu B unyolo ku terminal amino acid. Mankhwalawa amapangidwa ndi kampani yayikulu yopanga mankhwala ku France - Sanofi-Aventis. Popita maphunziro ambiri, zidatsimikiziridwa kuti insulin Lantus sikuti imangochepetsa chiopsezo cha hypoglycemia poyerekeza ndi mankhwala a NPH, komanso imathandizira kagayidwe kazachilengedwe. Pansipa pali malangizo achidule ogwiritsa ntchito ndi kuwunika kwa odwala matenda ashuga.

Chithandizo cha Lantus ndi insulin glargine. Amapezeka ndi majini obwezeretsanso pogwiritsa ntchito mtundu wa bak-12 wa bakiteriya Escherichia coli. M'malo osaloŵerera, samasungunuka pang'ono, mu acid acid sing'anga imasungunuka ndikupanga microprecipitate, yomwe imatulutsa insulini pang'onopang'ono. Chifukwa cha izi, Lantus ali ndi mbiri yosavuta kuchitira mpaka maola 24.

Kupanga kwakukulu pa pharmacological:

• Ochepa adsorption ndi mbiri yopanda kanthu mkati maola 24.
• Kuponderezedwa kwa proteinolysis ndi lipolysis mu adipocytes.
• Gawo lolimbikira limamangirira ma insulin receptors maulendo 5-8 mwamphamvu.
• Kukuwongolera kagayidwe kachakudya kagayidwe kachakudya, kupewera kwa shuga m'magazi.

Mu 1 ml Lantus Solostar muli:

• 3.6378 mg wa insulin glargine (malinga ndi 100 IU ya insulin ya anthu),
• 85% glycerol
• madzi a jakisoni
• hydrochloric wozungulira asidi,
• m-cresol ndi sodium hydroxide.

Kusintha kupita ku Lantus kuchokera ku insulin ina

Ngati munthu wodwala matenda ashuga agwiritsa ntchito ma insulin apakatikati, ndiye kuti musinthana ndi Lantus, muyezo ndi mtundu wa mankhwalawo umasinthidwa. Kusintha kwa insulin kuyenera kuchitika kokha kuchipatala.

Ku Russia, onse odwala matenda a shuga omwe amadalira insulin adasamutsidwa kuchoka ku Lantus kupita ku Tujeo. Malinga ndi kafukufuku, mankhwalawa ali ndi chiopsezo chochepa cha kukhala ndi hypoglycemia, koma machitidwe, anthu ambiri amadandaula kuti atasinthira ku Tujeo shuga wawo adalumphira kwambiri, motero amakakamizidwa kugula okha Lantus Solostar insulin.

Levemir ndi mankhwala abwino kwambiri, koma ali ndi chinthu china chogwira ntchito, ngakhale nthawi yayitali ndi maola 24.

Aylar sanakumane ndi insulin, malangizo akuti uyu ndi Lantus yemweyo, koma wopanga ndi wotsika mtengo.

Insulin Lantus pa nthawi yapakati

Maphunziro a zachipatala a Lantus omwe ali ndi amayi apakati sanachitike. Malinga ndi zomwe sizinalembedwera, mankhwalawa samakhudza kwambiri mayendedwe a mwana komanso iyemwini.

Kuyesera kunachitika pa zinyama, pomwepo zimatsimikiziridwa kuti insulin glargine ilibe vuto la kubereka.

Lantus Solostar woyembekezera atha kutumikiridwa pokhapokha insulin NPH isagwire ntchito. Amayi amtsogolo akuyenera kuwunika shuga wawo, chifukwa mu trimester yoyamba, kufunika kwa insulin kumatha kuchepa, komanso mu trimester yachiwiri ndi yachitatu.

Osawopa kuyamwitsa mwana; malangizo ake alibe zomwe Lantus imatha kudutsa mkaka wa m'mawere.

Momwe mungasungire

Alumali moyo wa Lantus ndi zaka 3. Muyenera kusungira m'malo amdima otetezedwa ndi kuwala kwa dzuwa pa kutentha kwa madigiri 2 mpaka 8. Nthawi zambiri malo abwino kwambiri ndi firiji. Poterepa, onetsetsani kuti mwayang'ana kutentha, chifukwa kuzizira kwa insulin Lantus koletsedwa!

Kuyambira koyamba kugwiritsa ntchito, mankhwalawa amatha kusungidwa kwa mwezi umodzi m'malo opanda pake kutentha osaposa 25 digiri (osati mufiriji). Osagwiritsa ntchito insulin yomwe yatha.

Poti mugule, mtengo

Lantus Solostar amalembedwa mwaulere ndi mankhwala ndi endocrinologist. Komanso zimachitika kuti wodwala matenda ashuga ayenera kugula yekha mankhwala ku pharmacy. Mtengo wamba wa insulin ndi ma ruble 3300. Ku Ukraine, Lantus angagulidwe 1200 UAH.

Lantus ndi insulin wakale wa anthu.

Kutulutsa mawonekedwe ndi kapangidwe kake

Lantus imapangidwa ngati njira yankho la subcutaneous makonzedwe: owonekera, pafupifupi opanda khungu kapena amtundu (3 ml aliyense m'matayala osayimira galasi, makatoni asanu m'matumba achimake, 1 paketi imodzi yamatayala, 5 OptiClick carton system pamakatoni Syringe cholembera wa OptiSet pabokosi lamakatoni).

The 1 ml ya mankhwala akuphatikiza:

• Chithandizo chogwira ntchito: insulin glargine - 3.6378 mg (yofanana ndi zomwe zimapezeka mu insulin ya anthu - 100 PIECES),
• Zothandiza: zinc chloride, metacresol (m-cresol), 85% glycerol, sodium hydroxide, hydrochloric acid, madzi a jakisoni.

Zizindikiro zogwiritsidwa ntchito

1. Akuluakulu ndi ana ochokera zaka 2 zokhala ndi matenda amtundu wa 1.
2. Type 2 shuga mellitus (pankhani ya kulephera kwa mapiritsi).

Mukunenepa kwambiri, kuphatikiza mankhwalawa ndikothandiza - Lantus Solostar ndi Metformin.

Kuchita ndi mankhwala ena

Pali mankhwala omwe amakhudza kagayidwe kazakudya, pomwe akuwonjezera kapena kuchepetsa kufunika kwa insulin.

Chepetsa shuga: pakamwa antidiabetesic othandizira, sulfonamides, ACE zoletsa, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Onjezani shuga: mahomoni a chithokomiro, diuretics, sympathomimetics, kulera kwapakamwa, zotumphukira za phenothiazine, proteinase inhibitors.

Zinthu zina zimakhala ndi mphamvu ya hypoglycemic komanso hyperglycemic. Izi zikuphatikiza:

• beta blockers ndi mchere wa lithiamu,
• mowa
• clonidine (antihypertensive mankhwala).

Mlingo ndi makonzedwe

Mlingo wa Lantus ndi nthawi ya tsiku pakuwongolera kwake imayikidwa payekhapayekha.

Mankhwalawa amayenera kuperekedwa pang'onopang'ono (pamafuta ochepa a phewa, pamimba kapena ntchafu) 1 nthawi patsiku nthawi imodzi. Masamba a jakisoni amayenera kusinthidwa ndi makonzedwe atsopano aliwonse a Lantus m'malo omwe akutsimikiziridwa.

Mwina kugwiritsa ntchito Lantus ngati monotherapy kapena munthawi yomweyo ndi mankhwala ena a hypoglycemic.

Posamutsa odwala omwe ali ndi nthawi yayitali kapena akuyamba kuchita zolimbitsa thupi ku Lantus, pangafunike kusintha njira zothandizirana ndi antidiabetesic mankhwala, komanso mankhwala amkati mwa insulin kapena ma analogu awo kapena kusintha kwa tsiku ndi tsiku insulin.

Posamutsa odwala kuchokera ku kawiri ka insulin-isofan kupita ku chithandizo cha Lantus m'milungu yoyambirira yamankhwala, ndikofunikira kuchepetsa tsiku la insulin ndi 20-30% (kuchepetsa chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri). Panthawiyi, kuchepa kwa mulingo wa Lantus kuyenera kulipidwa ndi kuwonjezeka kwa Mlingo wa insulin yocheperako komanso muyezo wapamwamba uyenera kusinthidwanso.

Panthawi ya kusintha kwa Lantus komanso milungu yoyambirira zitatha izi, kuyang'anira shuga m'magazi ndikofunikira. Ngati ndi kotheka, sinthani mtundu wa insulin. Kusintha kwa dose kungafunikenso pazifukwa zina, mwachitsanzo, pakusintha momwe wodwalayo alili komanso kulemera kwa thupi, nthawi ya tsiku yopereka mankhwala, kapena pazinthu zina zomwe zimawonjezera chidwi chakukula kwa hyper- kapena hypoglycemia.

Mankhwala sayenera kugwiritsidwa ntchito kudzera mu mtsempha wa magazi kwambiri (hypoglycemia ingayambike). Musanayambe mawu oyamba, muyenera kuwonetsetsa kuti syringe ilibe zotsalira za mankhwala ena.

Musanagwiritse ntchito zolembera za sytige isanakwane ndi OptiSet, muyenera kuonetsetsa kuti yankho silikhala lopanda utoto, wowonekera, lofanana ndi madzi kapangidwe kake ndipo mulibe tinthu tolimba tomwe timayang'ana. Ma singano okha omwe ali ndi zolembera za sytiitet ya OptiSet angagwiritsidwe ntchito. Popewa matenda, munthu m'modzi yekha ndi amene ayenera kugwiritsa ntchito syringe yomwe imatulutsa.

Kuyanjana kwa mankhwala

Oral hypoglycemic othandizira, fluoxetine, angiotensin-otembenuza enzyme zoletsa, michere, disopyramide, dextropropoxyphene, pentoxifylline, salicylates ndi sulfanilamide antimicrobials angafunikire kuti achulukitse hypoglycemia ndi insulin hypoglycemic zotsatira, ndipo antimicritethth isayenere.

Ma mahomoni a chithokomiro, diuretics, glucocorticosteroids, diazoxide, danazole, isoniazid, ma antipsychotic (mwachitsanzo, clozapine kapena olanzapine), glucagon, progestogens, estrogens, somatotropin, phenothiazine, proathomoltamines theamp. , protease inhibitors (panthawiyi, kusintha kwa insulin kungafunike).

Kugwiritsa ntchito limodzi kwa insulin ndi pentamidine kungayambitse hypoglycemia, yomwe imatha m'malo mwa hyperglycemia. Pogwiritsa ntchito munthawi yomweyo Lantus wokhala ndi clonidine, beta-blockers, ethanol ndi lithiamu salt, kuwonjezeka ndi kuchepa kwa mphamvu ya insogulculin kumatha.

Ndi munthawi yomweyo kugwiritsa ntchito Lantus ndi mankhwala achifundo (clonidine, beta-blockers, guanfacin ndi reserpine) ndi chitukuko cha hypoglycemia, kuchepa kapena kusapezeka kwa zizindikiro za adrenergic kukaniza.

Lantus sayenera kusakanikirana kapena kuchepetsedwa ndi mankhwala ena a insulin kapena mankhwala ena aliwonse. Ikasungunuka kapena kusakanizidwa, mbiri yamachitidwe ake pakapita nthawi imatha kusintha. Zingathenso kutsogolera ku mpweya.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani pamalo amdima, osatheka ndi ana pa kutentha kwa 2-8 ° C, osazizira.

Moyo wa alumali ndi zaka zitatu.

Mukayamba kugwiritsa ntchito makatoni, ma OpitCet cartridge makatani ndi ma cholembera osakanizira a OptiSet ziyenera kusungidwa m'malo amdima, osawonekera kwa ana, kutentha mpaka 25 ° C m'makatoni awo.

Cholembera cha sytiitet cha OptiSet chisanafike sichiyenera kuzirala.

Tsiku lotha ntchito ku lantus m'makalata, makina a OptiClick makatoni ndi zolembera za syringe za OptiSet zisanachitike mutangoyamba kugwiritsa ntchito - mwezi umodzi.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Lantus . Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Lantus machitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Lantus analogues pali kupezeka kwa mawonekedwe. Gwiritsani ntchito mankhwalawa odwala matenda a shuga a odwala matenda a shuga, akulu, ana komanso pa nthawi ya bere. The zikuchokera mankhwala.

Lantus - ndi analogue ya insulin ya anthu. Kupezedwa ndi kubwezeretsanso kwa mabakiteriya a DNA amtundu wa Escherichia coli (E. coli) (tizilombo ta K12). Imakhala ndi solubility yochepa m'malo osalowerera ndale. Mu kapangidwe kamankhwala Lantus, imasungunuka kwathunthu, yomwe imatsimikiziridwa ndi chilengedwe acidic yankho la jakisoni (pH = 4). Pambuyo poyambitsa mafuta ochulukirapo, yankho, chifukwa cha acidity yake, limalowa mu mawonekedwe osakanikirana ndi mapangidwe a microprecipitates, omwe ochepa insulin glargine (chinthu chogwira kukonzekera kwa Lantus) amatulutsidwa nthawi zonse, ndikupereka chithunzi chosalala (chopanda). Kutalika kwa mankhwala.

Ma paramu omangira a insulin glargine ndi insulin ya anthu ali pafupi kwambiri. Glulin insulin imakhala ndi mphamvu yofanana ndi insulin.

Chochita chofunikira kwambiri cha insulini ndikukhazikitsidwa kwa kagayidwe ka glucose. Insulin ndi mawonekedwe ake amachepetsa shuga m'magazi ndikulimbikitsa kukoka kwa glucose pogwiritsa ntchito zotumphukira (makamaka mafupa a minofu ndi adipose minofu), komanso kuletsa mapangidwe a shuga mu chiwindi (gluconeogenesis). Insulin imalepheretsa adipocyte lipolysis ndi proteinol, pamene ikupanga kuphatikiza mapuloteni.

Kutalika kwa nthawi ya insulin glargine makamaka chifukwa cha kuchepa kwake, komwe kumapangitsa kuti mankhwalawa azigwiritsidwa ntchito kamodzi patsiku. Kukhazikika kwa pafupifupi ndi ola limodzi pambuyo pa sc makonzedwe. Kutalika kochedwa kwa maola ndi maola 24, kutalika kwake ndi maora 29. Chikhalidwe cha insulin ndi mawonekedwe ake (mwachitsanzo, insulin glargine) pakapita nthawi amatha kusiyanasiyana kwa odwala osiyanasiyana komanso kwa wodwala yemweyo.

Kutalika kwa mankhwala Lantus ndi chifukwa kukhazikitsidwa kwake mafuta oyambira.

Insulin glargine + akubwera.

Kafukufuku wofananira wa kuzungulira kwa insulin glargine ndi insulin-isophan pambuyo pokhazikika pamayendedwe a magazi mu seramu mwa anthu athanzi komanso odwala omwe ali ndi matenda osokoneza bongo amawulula kuchepa pang'onopang'ono komanso kutalikirana kwambiri, komanso kusapezeka kwa nsonga ya insulin glargine poyerekeza ndi insulin-isofan.

Ndi s / c pokonzekera mankhwalawa 1 kamodzi patsiku, khola la insulin glargine m'magazi limakwaniritsidwa patatha masiku awiri ndi atatu atatha kumwa.

Ndi mtsempha wamkati, theka la moyo wa insulin glargine ndi insulin yaumunthu imafanana.

Mwa munthu yemwe wakula mafuta osunthika, insulin glargine imakhazikika pang'ono kuchokera kumapeto kwa carboxyl (C-terminus) ya B unyolo (beta unyolo) kuti ipange 21A-Gly-insulin ndi 21A-Gly-des-30B-Thr-insulin. Mu plasma, onse insulin glargine osasinthika ndi zopangidwa ndi cleavage zilipo.

• matenda a shuga omwe amafunikira chithandizo cha insulin mwa akulu, achinyamata ndi ana opitilira zaka 6,
• shuga mellitus ofuna chithandizo cha insulin mwa akulu, achinyamata ndi ana opitilira zaka 2 (a fomu ya SoloStar).

Yankho la subcutaneous makonzedwe (3 ml makatiriji mu OptiSet ndi OptiKlik syringe zolembera).

Njira yothetsera ma subcutaneous makonzedwe (3 ml cartridgeges ku Lantus SoloStar syringe pens).

Malangizo ogwiritsa ntchito ndi chiwembu chogwiritsira ntchito

Lantus OptiSet ndi OptiKlik

Mlingo wa mankhwalawa komanso nthawi yakatsiku la kasamalidwe ake imayikidwa payekhapayekha. Lantus amatumizidwa kamodzi kamodzi patsiku, nthawi imodzi. Lantus amayenera kubayidwa m'mafuta am'mimba, phewa kapena ntchafu. Masamba obaya jekeseni amayenera kusinthana ndi mankhwala atsopano aliwonse omwe ali m'malo omwe akutsimikiziridwa kuti mankhwalawo ndi othandizira.

Mankhwalawa angagwiritsidwe ntchito onse ngati monotherapy, komanso kuphatikiza ndi mankhwala ena a hypoglycemic.

Posamutsa wodwala kuchokera ku insulin ya nthawi yayitali kapena yapakatikati yopita ku Lantus, pangafunike kukonza njira ya tsiku ndi tsiku ya basal insulin kapena kusintha kwa ofanana ndi mankhwala osokoneza bongo (Mlingo ndi mawonekedwe a makulidwe a insulin kapena malingaliro awo, komanso Mlingo wa mankhwala osokoneza bongo a hypoglycemic).

Mukasamutsa wodwala kuchokera pakulidwe ka insulin kawiri kawiri kulowa jekeseni imodzi ya Lantus, mlingo wa tsiku ndi tsiku wa basal insulin uyenera kuchepetsedwa ndi 20-30% m'milungu yoyamba yamankhwala kuti muchepetse chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri. Munthawi imeneyi, kuchepa kwa mulingo wa Lantus kuyenera kulipidwa ndi kuwonjezeka kwa Mlingo wa insulin yochepa, kenako ndikusintha kwa Mlingo wa mankhwala.

Monga ma fanizo ena a insulin yaumunthu, odwala omwe amalandira Mlingo wambiri wa mankhwala chifukwa cha kupezeka kwa ma antibodies kwa insulin ya anthu amatha kuwona kuwonjezeka kwa kuyamwa kwa insulin pamene akusintha kupita ku Lantus. Mukasinthira ku Lantus komanso milungu yoyamba itatha, kuyang'anira shuga m'magazi ndikofunikira ndipo ngati pakufunika kuthandizidwa, mupeze mankhwalawa.

Pofuna kusintha kwa kagayidwe kazinthu komanso kuwonjezereka kwa chidwi cha insulin, kuwongolera kwina kwa mankhwalawa kungakhale kofunikira. Kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwala, moyo, nthawi ya tsiku yoperekera mankhwala, kapena ngati zinthu zina zikuwoneka kuti zikuwonjezera kukonzekera kwa hypo- kapena hyperglycemia.

Mankhwala sayenera kuperekedwa. Mu / pakubweretsa njira yanthawi zonse, yomwe imapangidwira kukonzekera kwa sc, imatha kuyambitsa kukula kwa hypoglycemia.

Asanakhazikitsidwe, muyenera kuwonetsetsa kuti ma syringe alibe zotsalira zamankhwala ena.

Malamulo ogwiritsira ntchito ndikugwiritsa ntchito mankhwalawa

OptiSet asanadzaze ma syringe pensulo

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi. Ma cholembera opanda kanthu a OptiSet sanapangidwe kuti agwiritsenso ntchito ndipo akuyenera kuwonongeka.

Popewa kutenga kachilomboka, cholembera chomwe chimakhala chodzaza ndi chida chokha chogwiritsidwa ntchito ndi wodwala m'modzi yekha ndipo sichingasamutsidwe kwa munthu wina.

Kugwira cholembera cha OptiSet Syringe

Pa ntchito iliyonse yotsatira, gwiritsani ntchito singano yatsopano. Gwiritsani masingano okha oyenera cholembera cha OptiSet.

Jekeseni iliyonse isanachitike, kuyesedwa koyenera kuyenera kuchitidwa nthawi zonse.

Ngati cholembera chatsopano cha OptiSet chikugwiritsidwa ntchito, kukonzekera kuyesa kugwiritsa ntchito kuyenera kuchitika pogwiritsa ntchito magawo 8 osankhidwa ndi wopanga.

Wosankha mlingo akhoza kuzunguliridwa mbali imodzi.

Osatembenuza wokonza mlingo (kusintha kwa mlingo) mutakanikiza batani loyambira jakisoni.

Wina akapaka jakisoni kwa wodwala, ayenera kusamalidwa mwapadera kuti apewe kuvulala mwangozi ndi matenda opatsirana.

Osamagwiritsanso ntchito cholembera cha sytige ya OptiSet yowonongeka, komanso ngati vuto lakukayikira likuwoneka.

Ndikofunikira kukhala ndi cholembera cha sytige yopumira ya OptiSet ngati mutayika kapena kuwonongeka kwa omwe mumagwiritsa ntchito.

Mukachotsa chipewa mu syringe cholembera, onetsetsani zomwe zili patsamba losungirako la insulin kuti zitsimikizire kuti ili ndi insulin yoyenera. Maonekedwe a insulini ayeneranso kufufuzidwa: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, lopanda zinthu zolimba zowoneka komanso lokhazikika monga madzi. Osagwiritsa ntchito cholembera cha sytinge ya OptiSet ngati njira ya insulin ndi yopanda mitambo, yothinitsidwa kapena yokhala ndi tinthu tachilendo.

Mukachotsa kapu, samalirani mosamala ndikulowetsa singano ndi cholembera.

Kuyang'ana kukonzeka kwa cholembera kuti mugwiritse ntchito

Pamaso pa jekeseni iliyonse, ndikofunikira kuyang'ana kukonzekera kwa cholembera kuti mugwiritse ntchito.

Kwa cholembera chatsopano chatsopano komanso chosagwiritsidwa ntchito, chizindikiro cha mankhwalawa chiyenera kukhala nambala 8, monga momwe zimapangidwira kale ndi wopanga.

Ngati cholembera chikagwiritsidwa ntchito, wopereka amayenera kuzunguliridwa mpaka chizindikiritso cha mankhwalawo chikuima nambala 2. Wowunikirawo azizungulira mbali imodzi yokha.

Kokani batani loyambira kwathunthu kuti mupeze mlingo. Osazungulira wosankha wa mankhwalawo mutatha batani loyambira litulutsidwe.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa. Sungani kapu yakunja kuti mupeze singano yogwiritsidwa ntchito.

Mukugwira cholembera ndi singano yoloza m'mwamba, ikani pang'onopang'ono zitsulo za insulini ndi chala chanu kuti thovu lakumwamba lithe kulunjika ku singano.

Pambuyo pake, dinani batani loyambira njira yonse.

Ngati dontho la insulin litulutsidwa kuchokera kunsonga ya singano, cholembera cha singano ndi singano chimagwira ntchito molondola.

Ngati dontho la insulin silikuwoneka pamphepete mwa singano, muyenera kubwereza kuyeserera kwa cholembera kuti mugwiritse ntchito mpaka insulin itaonekere kumapeto kwa singano.

Mankhwala a insulin

Mlingo wa mayunitsi 2 mpaka 40 ungayikidwe mu zowonjezera za 2 mayunitsi. Ngati mlingo wopitilira mayunitsi 40 ukufunika, uyenera kutumikiridwa pobayira ziwiri kapena zingapo. Onetsetsani kuti muli ndi insulin yokwanira muyezo wanu.

Mulingo wa insulin yotsalira pachidebe cha insulin imawonetsa kuchuluka kwa insulini yotsalira mu cholembera cha sytiitet ya OptiSet. Mlingowu sungagwiritsidwe ntchito kumwa mankhwala a insulin.

Ngati piston wakuda ali kumayambiriro kwa mzere wachikuda, ndiye kuti pali magawo 40 a insulin.

Ngati pisitoni wakuda ili kumapeto kwa mzere wachikuda, ndiye kuti pali magawo 20 a insulin.

Wosankha mlingo uyenera kutembenuzidwa mpaka muvi womwenso uwonetsa mlingo womwe ungafune.

Kumwa kwa insulin

Batani loyambira jekeseni liyenera kukokedwa mpaka kumalizira kuti mudzaze cholembera.

Ziyenera kuwunikidwa ngati mulingo wofunikira uli ndi zonse. Batani loyambira limasuntha molingana ndi kuchuluka kwa insulini yomwe yatsala mu thanki ya insulin.

Yambitsani batani limakupatsani mwayi kuti muone ngati ndiwomwe udayamwa. Mukamayesedwa, batani loyambira liyenera kupitilizidwa mphamvu. Mzere womaliza wowoneka bwino pabatani wayambira kuchuluka kwa insulin yomwe yatengedwa. Pokhazikitsa batani loyambira, pamwamba pamzerewu ndiwowoneka.

Ophunzitsidwa mwapadera ayenera kufotokozera wodwalayo njirayo.

Singano imalowetsedwa pang'onopang'ono. Batani loyambira jekeseni liyenera kukanikizidwa mpaka pakufika. Kungodinanso kukusiyani pomwe batani la jekeseni litakankhidwa njira yonse.Kenako, batani loyambira jakisoni liyenera kusindikizidwa kwa masekondi 10 musanachotsere singano pakhungu. Izi zitsimikiza kukhazikitsidwa kwa mlingo wonse wa insulin.

Pakapita jakisoni aliyense, singano imayenera kuchotsedwa mu cholembera ndikuchotsa. Izi zimathandiza kupewa matenda, komanso kutayika kwa insulini, kudya kwa mpweya komanso kuthekera kwa singano. Singano sizingagwiritsenso ntchito.

Pambuyo pake, valani chipewa cha syringe cholembera.

Makatoni amayenera kugwiritsidwa ntchito limodzi ndi cholembera cha syringe ya OptiPen Pro1, komanso molingana ndi malingaliro omwe adaperekedwa ndi wopanga chipangizocho.

Malangizo ogwiritsira ntchito cholembera cha sytige ya OptiPen Pro1 okhudza kukhazikitsidwa kwa katiriji, zolumikizira singano, ndi jakisoni wa insulin ziyenera kutsatiridwa chimodzimodzi. Yenderani cartridge musanagwiritse ntchito. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe tizinthu totsimikizika tolimba. Asanakhazikitse cartridge mu syringe cholembera, cartridge iyenera kukhala pakupanda kutentha kwa maola 1-2. Musanalowetse jakisoni, chotsani thovu lakumtunda. Ndikofunikira kutsatira mosamalitsa malangizo. Makatoni opanda kanthu sagwiritsidwanso ntchito. Ngati cholembera cha sytiit ya OptiPen Pro1 chawonongeka, simuyenera kuchigwiritsa ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala posankha yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochita 100 IU / ml).

Optical Dinani Cartridge System

Pulogalamu yama cartridge ya OptiClick ndi kapu yagalasi yokhala ndi 3 ml ya insulin glargine solution, yomwe imayikidwa mu chidebe chowoneka bwino cha pulasitiki chomwe chili ndi zida za piston.

Dongosolo la cartridge la OptiClick liyenera kugwiritsidwa ntchito limodzi ndi cholembera cha sytinge ya OptiClick molingana ndi malangizo ogwiritsira ntchito omwe adabwera nawo.

Ngati cholembera cha sytiit ya OptiClick chawonongeka, chotsani ndi chatsopano.

Asanakhazikitse dongosolo la cartridge mu cholembera cha sytiit ya OptiClick, liyenera kukhala kutentha kwa firiji kwa maola 1-2. Njira yama cartridge iyenera kuyang'aniridwa isanayikidwe. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe zinthu zophatikizika. Pamaso jakisoni, thovu la mpweya liyenera kuchotsedwa mu dongosolo lama cartridge (lofanana ndi cholembera). Makina a cartridge opanda kanthu sagwiritsidwanso ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala polemba yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochitika 100 IU / ml).

Popewa matenda, munthu m'modzi yekha ndi amene ayenera kugwiritsa ntchito cholembera.

Lantus SoloStar iyenera kuyendetsedwa mosavomerezeka kamodzi patsiku nthawi ina iliyonse, koma tsiku lililonse nthawi imodzi.

Odwala omwe ali ndi matenda a shuga 2, Lantus SoloStar angagwiritsidwe ntchito ngati monotherapy komanso kuphatikiza mankhwala ena a hypoglycemic. Cholinga cha shuga wamagazi, komanso Mlingo ndi nthawi ya makonzedwe kapena makonzedwe a hypoglycemic ayenera kutsimikizika ndikusintha payekhapayekha.

Kusintha kwa magazi kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwalayo, moyo wawo, kusintha nthawi ya makulidwe a insulin, kapena mikhalidwe ina yomwe ingalimbikitse chidwi chakukula kwa hypo- kapena hyperglycemia. Kusintha kulikonse kwa insulin kuyenera kuchitika mosamala komanso moyang'aniridwa ndi achipatala.

Lantus SoloStar si insulin yosankha yochizira matenda ashuga ketoacidosis. Pankhaniyi, kukondera kuyenera kuperekedwa / pakubweretsa insulin yochepa. Mu mankhwalawa othandizira kuphatikiza jakisoni wa basal ndi prandial insulin, 40-60% ya mlingo wa insulin tsiku lililonse wa insulin glargine nthawi zambiri amatumizidwa kuti akwaniritse zosowa za insulin.

Odwala omwe ali ndi matenda a shuga 2 amwa mankhwalawa amamwa mankhwala a hypoglycemic pakamwa, kuphatikiza mankhwalawa kumayamba ndi mlingo wa insulin glargine 10 PESCES 1 nthawi patsiku ndipo njira yotsatira yamankhwala imasinthidwa payekhapayekha.

Kusintha kuchokera ku chithandizo ndi mankhwala ena a hypoglycemic kupita ku Lantus SoloStar

Posamutsa wodwala ku njira yochiritsira yogwiritsa ntchito nthawi yayitali kapena insulini yodwala pakanthawi kogwiritsira ntchito Lantus SoloStar, zingakhale zofunikira kusintha kuchuluka kwake (kuchuluka) ndi nthawi ya makulidwe a insulin yocheperako kapena analogue yake masana kapena kusintha Mlingo wamankhwala osokoneza bongo a hypoglycemic.

Posamutsa odwala kuchokera jakisoni imodzi ya insulin-isofan patsiku kupita ku mankhwala amodzi masana, Lantus SoloStar samasintha kawirikawiri mlingo woyambirira wa insulin (i., Kuchuluka kwa Lantus SoloStar Units patsiku lofanana ndi kuchuluka kwa IN insulin isofan patsiku).

Posamutsa odwala kuti atumize insulin-isophan kawiri masana kuti apange jekeseni imodzi ya Lantus SoloStar asanagone kuti achepetse vuto la hypoglycemia usiku ndi m'mawa kwambiri, mankhwalawa a insulin glargine nthawi zambiri amachepetsedwa ndi 20% (poyerekeza ndi insulin ya tsiku ndi tsiku isophane), kenako imasinthidwa malinga ndi yankho la wodwalayo.

Lantus SoloStar sayenera kusakanikirana kapena kuchepetsedwa ndi mankhwala ena a insulin. Onetsetsani kuti ma syringe alibe zotsalira zamankhwala ena. Mukasakaniza kapena kuchepetsera, mawonekedwe a insulin glargine amatha kusintha pakapita nthawi.

Posintha kuchokera ku insulin ya anthu kupita ku mankhwala a Lantus SoloStar komanso milungu yoyambirira itatha, kuyang'aniridwa mosamala kwa kagayidwe kamwazi m'magazi) moyang'aniridwa ndi achipatala akulimbikitsidwa, ndikuwongolera mlingo wa insulin ngati pakufunika. Monga ma fanizo ena a insulin yaumunthu, izi ndizofunikira kwambiri kwa odwala omwe, chifukwa cha kupezeka kwa ma antibodies a insulin ya anthu, ayenera kugwiritsa ntchito Mlingo waukulu wa insulin ya anthu. Odwala oterowo, akamagwiritsa ntchito insulin glargine, kusintha kwakukulu poyankha kutsata insulin kumawonedwa.

Ndi bwino kagayidwe kachakudya ndi kuchuluka kwa minyewa kumva insulin, pangafunikire kusintha mlingo wa insulin.

Kusakaniza ndi kuswana

Mankhwala Lantus SoloStar sayenera kusakanikirana ndi ma insulini ena. Kusakaniza kungasinthe kuchuluka kwa nthawi / mphamvu ya mankhwala Lantus SoloStar, komanso kutsogolera ku mpweya.

Magulu apadera a odwala

Mankhwala Lantus SoloStar angagwiritsidwe ntchito mwa ana okulirapo zaka 2. Ntchito ana osaposa zaka 2 sizinaphunzire.

Kwa odwala okalamba omwe ali ndi matenda a shuga, ndikulimbikitsidwa kugwiritsa ntchito Mlingo woyambirira, kuwonjezereka kwawo pang'onopang'ono komanso kugwiritsa ntchito Mlingo wowonjezera.

Mankhwala Lantus SoloStar amaperekedwa ngati jakisoni wa sc. Mankhwala Lantus SoloStar silinapangidwe kuti likhale ndi mtsempha wowonjezera.

Kutalika kwazinthu zambiri za insulin glargine zimawonedwa pokhapokha ngati zimayambitsidwa ndi mafuta osaneneka. Mu / kumayambiriro kwa chizolowezi subcutaneous mlingo zingayambitse kwambiri hypoglycemia. Lantus SoloStar iyenera kuyambitsidwa mu mafuta ochulukitsa a m'mimba, mapewa kapena m'chiuno. Masamba a jakisoni amayenera kusinthana ndi jakisoni aliyense watsopano m'malo omwe akutsimikiziridwa kuti mupeze mankhwala. Monga momwe zimakhalira ndi mitundu ina ya insulini, kuchuluka kwa mayamwidwe, ndipo, chifukwa, zoyambira ndi nthawi yake yochitikira, zimatha kusiyanasiyana mothandizidwa ndi zochitika zolimbitsa thupi komanso kusintha kwina kwa wodwalayo.

Lantus SoloStar ndi yankho lomveka bwino, osati kuyimitsidwa. Chifukwa chake, kupumulanso musanagwiritse ntchito sikofunikira. Pakasokonekera cholembera cha Lantus SoloStar, insulin glargine imatha kuchotsedwa mu katiriji mu syringe (yoyenera insulin 100 IU / ml) ndipo jakisoni wofunikira ukhoza kupangidwa.

Malamulo ogwiritsira ntchito ndi kusamalira cholembera chodzaza ndi SoloStar

Asanayambe kugwiritsa ntchito, cholembera cha syringe chimasungidwa kutentha kwa firiji kwa maola 1-2.

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi.

Ma syringe a SoloStar opanda kanthu sayenera kugwiritsidwanso ntchito ndipo ayenera kutayidwa.

Popewa matenda, cholembera chodzaza chisanachitike chizingogwiritsidwa ntchito ndi wodwala m'modzi ndipo sayenera kusamutsidwira wina.

Musanagwiritse ntchito cholembera cha SoloStar, werengani mosamala zidziwitso pakugwiritsa ntchito.

Musanagwiritse ntchito, gwiritsani ntchito singano yatsopano ndi cholembera chonde ndikuyesa mayeso. Ma singano okhawo omwe amagwirizana ndi SoloStar ayenera kugwiritsidwa ntchito.

Malangizo apadera amayenera kuchitika popewa ngozi zokhudzana ndi kugwiritsa ntchito singano komanso mwayi wopatsira matenda.

Palibe chifukwa chomwe muyenera kugwiritsira ntchito cholembera cha SoloStar ngati chawonongeka kapena ngati mukukayikira kuti chitha kugwira ntchito moyenera.

Muyenera kukhala ndi cholembera cha syringe ya SoloStar nthawi zonse ngati mungataye kapena kuwononga cholembera cha SoloStar.

Ngati cholembera cha SoloStar sichisungidwa mufiriji, chizichotsa maola awiri jekeseni isanachitike kuti yankho lithe kutentha. Makamaka insulini yodziwika bwino imapweteka kwambiri. Cholembera cha SoloStar chogwiritsidwa ntchito chimayenera kuwonongeka.

SoloStar syringe cholembera iyenera kutetezedwa kufumbi ndi litsiro. Kunja kwa cholembera cha SoloStar kumatha kutsukidwa ndikukupukuta ndi nsalu yonyowa. Osamiza m'madzi, kutsuka ndikuphika cholembera cha SoloStar, chifukwa izi zitha kuwononga.

Cholembera cha SoloStar chimatulutsa bwino insulin ndipo ndi chida kugwiritsa ntchito. Zimafunikanso kusamala mosamala. Pewani zochitika zomwe zingawononge cholembera cha SoloStar. Ngati mukukayikira kuwonongeka kwa cholembera cha SoloStar, gwiritsani ntchito cholembera chatsopano.

Gawo 1. Kuwongolera kwa insulin

Muyenera kuyang'ana cholembera pa cholembera cha SoloStar kuti mutsimikizire kuti ili ndi insulin yoyenera. Kwa Lantus, cholembera cha syloge ya SoloStar imakhala imvi ndi batani lofiirira pobayira. Pambuyo pochotsa kapu ya cholembera, ma insulini omwe ali momwemo amawongolera: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, losakhala ndi tinthu tolimba tomwe timakhala ngati madzi.

Gawo 2. Kulumikiza singano

Ma singano okhawo omwe amagwirizana ndi cholembera cha SoloStar ndi omwe akuyenera kugwiritsidwa ntchito. Pa jakisoni wotsatira, gwiritsani ntchito singano yatsopano yosabala. Pambuyo pochotsa chipewa, singano iyenera kuyikiridwa mosamala pa cholembera.

Gawo 3. Kuchita mayeso a chitetezo

Pamaso pa jekeseni iliyonse, ndikofunikira kuyeserera chitetezo ndikuonetsetsa kuti cholembera ndi singano zimagwira bwino komanso thovu lakum air limachotsedwa.

Muyezo Mlingo wofanana magawo awiri.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa.

Ikani cholembera ndi singano kumtunda, ikani pang'onopang'ono katoni ya insulini ndi chala chanu kuti thovu lonse lakumwamba litayendetsedwe ku singano.

Kanikizani bwino batani la jakisoni.

Ngati insulini ikuwonekera pachimake pa singano, izi zikutanthauza kuti cholembera ndi singano zikugwira ntchito moyenera.

Ngati insulini siziwoneka pamphepete mwa singano, ndiye kuti gawo 3 limatha kubwerezedwanso mpaka insulini ikawonekera pamsonga pa singano.

Gawo 4. Kusankha Mafuta

Mlingo ukhoza kukhazikitsidwa ndikulondola kwa 1 unit kuyambira pa mlingo wochepa (1 unit) mpaka mlingo waukulu (80 magawo).Ngati kuli koyenera kukhazikitsa mlingo wowonjezera wamagulu a 80, jakisoni wa 2 kapena kupitilira aperekedwe.

Zenera la dosing liyenera kuwonetsa "0" ndikamaliza kuyesa kwa chitetezo. Pambuyo pake, mlingo wofunikira ukhoza kukhazikitsidwa.

Gawo 5. Mlingo

Wodwala ayenera kudziwitsidwa za njira ya jakisoni ndi katswiri wazachipatala.

Singano iyenera kuyikiridwa pansi pa khungu.

Batani la jakisoni liyenera kukanikizidwa kwathunthu. Imachitika pamalo amenewa kwa masekondi 10 mpaka singano itachotsedwa. Izi zimathandizira kuyambitsa mtundu wa insulin kwathunthu.

Gawo 6. Kuchotsa ndi kutaya singano

Mulimonsemo, singano pambuyo pa jekeseni aliyense ayenera kuchotsedwa ndikuchotsedwa. Izi zimathandizira kupewa kuipitsidwa ndi / kapena kutenga kachilomboka, kulowa mu chidebe cha insulin ndi kutulutsa insulin.

Pochotsa ndi kutaya singano, muyenera kusamala mosamala. Tsatirani njira zoyenera zotetezera pochotsa ndi singano (mwachitsanzo, njira ya dzanja limodzi) kuti muchepetse ngozi za ngozi zogwirizana ndi singano komanso kupewa matenda.

Mukachotsa singano, tsekani cholembera cha SoloStar ndi kapu.

• hypoglycemia - imayamba kumachitika pafupipafupi ngati mlingo wa insulin uposa kufunika kwake,
• kuzindikira "kutada" kapena kuwonongeka kwake,
• wodwala matenda opatsirana
• njala
• kusakhazikika
• thukuta lozizira
• tachycardia
• kuwonongeka kwamawonekedwe
• retinopathy
• lipodystrophy,
• dysgeusia,
• myalgia
• kutupa
• Matupi awo sagwirizana ndi insulin (kuphatikizapo insulin glargine) kapena magawo othandizira a mankhwalawa: khungu limakhudzanso, angioedema, bronchospasm, ochepa hypotension, mantha,
• redness, kupweteka, kuyabwa, ming'oma, kutupa kapena kutupa pamalo a jekeseni.

• zaka za ana mpaka zaka 6 za Lantus OptiSet ndi OptiKlik (pakadali pano palibe zambiri zakugwiritsa ntchito)
• zaka za ana mpaka zaka 2 za Lantus SoloStar (kusowa kwa chidziwitso cha chipatala pakugwiritsa ntchito),
• Hypersensitivity pamagawo a mankhwala.

Mimba komanso kuyamwa

Mosamala, Lantus iyenera kugwiritsidwa ntchito panthawi yapakati.

Kwa odwala omwe ali ndi vuto la matenda am'mbuyomu kapena gestational shuga, ndikofunikira kuti azikhala ndi nthawi yokwanira yogwiritsira ntchito metabolism. Mu nyengo ya 1 ya mimba, kufunika kwa insulin kumatha kuchepa, mu 2nd ndi 3 trimesters ikhoza kukulira. Amayi akangobadwa kumene, kufunika kwa insulini kumachepa, chifukwa chake chiopsezo chokhala ndi hypoglycemia chikuwonjezeka. Pansi pa izi, kuyang'anira shuga wamagazi ndikofunikira.

M'maphunziro oyesera a nyama, palibe deta yachindunji kapena yosalunjika yomwe idapezeka pa embryotoxic kapena fetotoxic of insulin glargine.

Sipanakhalepo mayesedwe azachipatala a chitetezo cha mankhwala Lantus panthawi yapakati. Pali umboni wa kugwiritsa ntchito kwa Lantus mwa azimayi 100 oyembekezera omwe ali ndi matenda ashuga. Maphunziridwe ake ndi zotsatira za kutenga pakati pa odwalawa sizinasiyanane ndi zomwe zimachitika mwa amayi apakati omwe ali ndi matenda ashuga omwe amalandiranso kukonzekera kwina kwa insulin.

Amayi pakuyamwitsa, kuwongolera kwa insulin dosing regimen ndi zakudya kungafunike.

Gwiritsani ntchito ana

Pakalipano palibe zambiri zamankhwala zomwe zimagwiritsidwa ntchito mwa ana ochepera zaka 6.

Gwiritsani ntchito odwala okalamba

Mwa odwala okalamba, kuwonongeka kwa pang'onopang'ono mu ntchito ya impso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin.

Lantus si mankhwala osankhidwa pochiza matenda ashuga a ketoacidosis. Zikatero, njira yolimbikira ya insulin yochepa imalimbikitsidwa.

Chifukwa chazocheperako ndi Lantus, sizinali zotheka kuwunika kuti magwiridwe ake ndi otetezeka pochiza odwala omwe ali ndi vuto la chiwindi kapena odwala omwe ali ndi kuperewera kwapakati kapena koopsa.

Odwala omwe ali ndi vuto laimpso, kufunika kwa insulini kumatha kuchepa chifukwa chakufooka kwa njira zake zowonongera. Mwa odwala okalamba, kuwonongeka kwa pang'onopang'ono mu ntchito ya impso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin.

Odwala omwe ali ndi vuto lalikulu la kuchepa kwa hepatic, kufunika kwa insulin kumatha kuchepetsedwa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis ndi biotransfform ya insulin.

Pankhani ya kusakwanitsa kuyang'anira kuchuluka kwa shuga m'magazi, komanso ngati pali chizolowezi chokhala ndi hypo- kapena hyperglycemia, musanapitirize kukonza mankhwala, ndikofunikira kuyang'ana kulondola kwa kutsata njira, mankhwala omwe makonzedwe a mankhwalawo amathandizira komanso njira ya jekeseni yothandiza sc. , poganizira zonse zomwe zimayambitsa.

Nthawi ya kukonzekera kwa hypoglycemia zimatengera mawonekedwe a omwe amagwiritsidwa ntchito chifukwa cha insulin, motero, angasinthe ndikusintha kwa regimen yothandizira. Chifukwa cha kuchuluka kwa nthawi yomwe imagwira ntchito Lantus, munthu akuyenera kuyembekezera kuchepa kwa nthawi yayitali, pomwe m'mawa kwambiri izi zimachitika. Ngati hypoglycemia imapezeka mwa odwala omwe amalandila Lantus, mwayi wochepetsera kutuluka kwa hypoglycemia chifukwa cha nthawi yayitali ya insulin glargine uyenera kuganiziridwanso.

Odwala omwe ma episode a hypoglycemia atha kukhala ndi matendawo, kuphatikizapo ndi stenosis yayikulu yamitsempha yama ziwalo zam'mimba kapena ziwongo (chiopsezo cha matenda a mtima ndi matenda a chithokomiro), komanso odwala omwe ali ndi proliferative retinopathy, makamaka ngati salandira chithandizo cha kuchepa kwa khungu chifukwa cha kuchepa kwa masokonezo chifukwa cha hypoglycemia), kusamalidwa kwapadera kuyenera kuyang'aniridwa ndikuwunikidwa mosamala. shuga wamagazi.

Odwala ayenera kuchenjezedwa pazochitika zomwe zingayambitse kuchepa kwa ziwonetsero za hypoglycemia, kusatchulika kapena kusapezeka m'magulu ena omwe ali pachiwopsezo, monga:

• odwala omwe asintha kwambiri magazi a shuga,
• odwala omwe hypoglycemia imayamba pang'onopang'ono,
• odwala okalamba
• odwala a neuropathy
• odwala matenda ashuga a nthawi yayitali
• odwala omwe ali ndi mavuto amisala
• odwala omwe adachokera ku insulin ya nyama kupita ku insulin yaumunthu,
• odwala kulandira chithandizo chamankhwala ena ndi ena.

Zochitika zoterezi zimatha kuyambitsa kukula kwa hypoglycemia (kutayika kwa chikumbumtima) wodwala asanadziwe kuti akupanga hypoglycemia.

Masewera a hemoglobin atakhala abwinobwino kapena kuchepa kwambiri, ndikofunikira kulingalira za mwayi wokhala ndi zigawo za hypoglycemia zomwe zimachitika mobwerezabwereza (makamaka usiku).

Kutsatira kwodalirika kwa mankhwala a dosing, zakudya, ndi zakudya, kugwiritsa ntchito bwino insulin, komanso kuwongolera kuyambika kwa zizindikiro za hypoglycemia kumathandizira kuchepetsa kwambiri chiopsezo cha hypoglycemia. Pamaso pa zinthu zomwe zimapangitsa chidwi cha hypoglycemia, makamaka kuyang'anitsitsa ndikofunikira, chifukwa kusintha kwa insulin kungafunike. Izi ndi monga:

• Kusintha kwa malo makonzedwe a insulin,
• kuchuluka kwa insulin (mwachitsanzo, mukamachotsa kupsinjika),
• zodabwitsa, zolimbitsa thupi kapena zotalika,
• Matenda oyamba limodzi ndi kusanza, kutsekula m'mimba,
• kuphwanya zakudya ndi zakudya,
• adadula chakudya
• kumwa mowa
• matenda ena osagwirizana ndi endocrine (mwachitsanzo, hypothyroidism, kusakwanira kwa adenohypophysis kapena adrenal cortex),
• chithandizo chamankhwala ena.

Mu matenda apakati, kuyamwa kwamphamvu kwa magazi pamafunika. Mwambiri, kusanthula kumachitika kuti pakhale matupi a ketone mumkodzo, ndipo insulin dosing imafunikira nthawi zambiri. Kufunika kwa insulin nthawi zambiri kumachuluka. Odwala omwe ali ndi matenda amtundu wa 1 ayenera kupitiliratu kudya zakudya zochepa, ngakhale mutangodya zochepa kapena osadya, komanso kusanza. Odwala awa sayenera kusiya kuperekera insulin.

Oral hypoglycemic agents, ACE inhibitors, disopyramides, fibrate, fluoxetine, mao inhibitors, pentoxifylline, dextropropoxyphene, salicylates ndi sulfonamide antimicrobials amatha kupititsa patsogolo hypoglycemic zotsatira za insulin ndikuwonjezera kutanthauzira pakukula kwa hypoglycemia. Ndi kuphatikiza uku, kusintha kwa insulin glargine kungafunike.

Glucocorticosteroids (GCS), danazole, diazoxide, okodzetsa, glucagon, isoniazid, estrogens, progestogens, phenothiazine zotumphukira, somatotropin, sympathomimetics (mwachitsanzo epinephrine, salbutamol, terbutaline), mahomoni a chithokomiro, ) itha kuchepetsa hypoglycemic zotsatira za insulin. Ndi kuphatikiza uku, kusintha kwa insulin glargine kungafunike.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Lantus okhala ndi beta-blockers, clonidine, lithiamu salt, ethanol (mowa), kuwonjezeka ndi kuchepa kwa mphamvu ya insogulculin kumatha. Pentamidine ikaphatikizidwa ndi insulin imatha kuyambitsa hypoglycemia, yomwe nthawi zina imasinthidwa ndi hyperglycemia.

Pogwiritsa ntchito munthawi yomweyo mankhwala osokoneza bongo omwe ali ndi mtima wachifundo, monga beta-blockers, clonidine, guanfacine ndi reserpine, kuchepa kapena kusapezeka kwa zizindikiro za adrenergic antigenergic (activation ya amamvekere a dongosolo lamanjenje) ndi kukula kwa hypoglycemia ndikotheka.

Lantus sayenera kusakanikirana ndi insulin ina yokonzekera, ndi mankhwala ena aliwonse, kapena kuchepetsedwa. Mukasakanikirana kapena kuchepetsedwa, mawonekedwe amachitidwe ake amatha kusintha pakapita nthawi, kuphatikiza, kusakanikirana ndi ma insulin ena kungayambitse mpweya.

Mndandanda wa mankhwala Lantus

Zofanana muzochitika zamagulu:

• Insulin glargine,
• Lantus SoloStar.

Analogs kwa achire zotsatira (mankhwalawa zochizira insulin-wodwala matenda a shuga):

• Khalid
• Anvistat
• Apidra
• B. Insulin
• Berlinulin,
• Biosulin
• Glyformin
• Glucobay,
• Depot insulin C,
• Dibikor
• Isofan Insulin World Cup,
• Iletin
• Insulin Isofanicum,
• Tepi ya insulin,
• Insulin Maxirapid B,
• Insulin sungunuka
• Insulinnt
• Insulin Ultralente,
• Insulin yayitali
• Insulin Ultralong,
• Insuman
• Pakati
• Comb-insulin C
• Levemir Penfill,
• Levemir Phukira,
• Metformin
• Mikstard
• Monosuinsulin MK,
• Monotard
• NovoMiks,
• NovoRapid,
• Pensulin,
• Protafan
• Rinsulin
• Stylamine
• Thorvacard
• Tricor
• Ultratard
• Humalog,
• Humulin,
• Cigapan
• Erbisol.

Pakusowa kwa kufananiza kwa mankhwala omwe amagwira ntchito, mutha kuwonekera pazolumikizana pansipa ndi matenda omwe mankhwala oyenera amathandizira ndikuwona mawonekedwe ofananira achire.

Kuphatikizika, mawonekedwe omasulidwa

Kuti mugwiritse ntchito moyenera, mankhwalawa amamasulidwa mwanjira yopanda mtundu. Chofunikira kwambiri pakuphatikizidwa kwake ndi Glulin insulin.

Kuphatikiza apo, yankho limaphatikizapo:

• madzi
• nthaka ya chloride
• sodium hydroxide
• glycerol
• hydrochloric acid,
• metacresol.

Odwala atha kugwiritsa ntchito mitundu ya mankhwala monga:

1. Dongosolo la OptiClick. Ili ndi ma cartridge 5.
2. Syringe cholembera OptiSet. Chiwerengero chawo paphukusi ndi 5 ma PC.
3. Lantus Solostar. Poterepa, makatoni amaikidwa mu cholembera. Pazonse, pali ma cholembera asanu ndi atatu mu phukusi.

Mankhwalawa amagwiritsidwa ntchito ngati ma jakisoni a subcutaneous komanso pokhapokha ngati dokotala akuwalimbikitsa.

Zizindikiro ndi contraindication

Mankhwalawa amayenera kugwiritsidwa ntchito pokhapokha ngati adalangizidwa ndi dokotala. Ngakhale atazindikira koyenera, zimakhala zovuta kwambiri kuti wodwalayo adziwe ngati angalandire chithandizo chamankhwala. Kuphatikiza apo, chifukwa cha mawonekedwe ena a thupi la wodwalayo, Lantus itha kukhala yovulaza, ndikofunika kuyeserera koyambirira.

Chizindikiro chachikulu chogwiritsa ntchito insulin yothandizira ndi matenda a shuga. Nthawi zambiri amagwiritsidwa ntchito ngati monotherapy. Koma pali nthawi zina pamene mankhwala ena amaphatikizidwa kuwonjezera pa iwo.

Mwa zina zotsutsana nthawi zambiri zimatchulidwa:

• Zaka zodwala ndi zosakwana zaka 6,
• chidwi cha thupi pakupanga.

Nthawi zina pamakhala mikangano.

Izi zikuphatikiza:

• mimba
• kuyamwitsa
• matenda a chiwindi
• kuphwanya impso ntchito,
• ukalamba.

Izi ndi zina mwa zomwe sangathe kuchita. Ngati ndi kotheka, Lantus ikhoza kugwiritsidwa ntchito, koma ndikofunikira kuwongolera kuchuluka kwa shuga, popeza magulu awa a odwala amakonda kwambiri hypoglycemia.

Mitundu ya kumasulidwa ndi mtengo wa mankhwalawo

Zomwe zimagwiritsa ntchito mankhwalawa ndi glargine ya mahomoni. Zothandiza zimaphatikizidwanso: zinc chloride, hydrochloric acid, m-cresol, sodium hydroxide, madzi a jakisoni ndi glycerol. Mankhwalawa amasiyana ndi mitundu yambiri ya insulin momwe amamasulidwa.

• OptiKlik - phukusi limodzi lili ndi makatoni 5 a 3 ml iliyonse. Makatoni amapangidwa ndigalasi labwino.
• Khola la syringe, logwiritsidwa ntchito mophweka - ndi kukhudza kwa chala, lakonzedwanso 3ml.
• Lantus SoloStar makatiriji ali ndi 3 ml ya thunthu. Makatoni awa amaikiratu cholembera. Pali zolembera 5 zotere mu phukusi, zokha zimangogulitsidwa popanda singano.

Mankhwalawa ndi mankhwala omwe akhala akuchita kwa nthawi yayitali. Koma kodi Lantus insulin imawononga ndalama zingati?

Mankhwala amagulitsidwa ndi mankhwala, amagawidwa pakati pa odwala matenda ashuga, mtengo wake ndi 3200 rubles.

Munthu akadwala matenda ashuga, ayenera kugwiritsa ntchito jakisoni wa insulin. Izi zimabweretsa mafunso: ndi chida chiti chomwe mungasankhire? Kodi chithandizo ndi chambiri komanso kusankha mankhwala okwera mtengo? Kodi pali kusiyana pakati pa Lantus ndi Solostar, iti ndiyabwino?

Kangati patsiku kuti mupereke jakisoni ndi nthawi yotalikirapo bwanji pakati pa jakisoni? Tiona imodzi yamankhwala amakono, yesani kupeza chomwe angasankhe - insulin glargine kapena mankhwala ofananawo, komanso mtengo wake.

Lantus ndi mankhwala amakono a insulin omwe machitidwe awo amachepetsa shuga m'thupi. Glulin insulin ndiye chinthu chachikulu chomwe chimagwiritsa ntchito mankhwalawa, omwe samasungunuka bwino mu ndale za ph ndipo amagwirizana kwathunthu ndi insulin ya anthu. Lantus ndi insulin glargine - mayina awiri a mankhwalawa. Ganizirani zofunika za malangizo ogwiritsira ntchito mankhwala "insulin Lantus."

Chida ichi ndi yankho momwe gawo lalikulu limayendetsedwa ndi chilengedwe chapadera cha acid. Chifukwa cha izo, Kutha kwathunthu kumachitika. Ikagwiritsidwa ntchito pang'onopang'ono, asidiyo samatulutsa, microprecipitates imapangidwa, kuchokera kwa iwo chinthu chogwira ntchito chimatuluka m'magazi. Mlingo wochepa wa izo pang'onopang'ono umalowa m'madzi a m'magazi, kupatula kuwonjezeka kwambiri kwa insulin.

Chifukwa cha microprecipitate, mankhwalawa ali ndi mphamvu yayitali (kuyambira tsiku limodzi, ola limodzi mutatha kugwiritsa ntchito).

Momwe mungagwiritsire ntchito Lantus

Mukamagwiritsa ntchito, tsatirani malamulowo:

1. Kukhazikitsidwa kwa mankhwalawa kumachitika ndi gawo la mafuta ochepa a ntchafu kapena phewa, matako, khoma lamkati lakumbuyo. Mankhwalawa amagwiritsidwa ntchito kamodzi tsiku lililonse, malo a jakisoni amasintha, ndipo nthawi yofanana imasungidwa pakati pajekeseni.
2. Mlingo ndi nthawi ya jakisoni zimatsimikiziridwa ndi dokotala - magawo awa ndi amodzi. Mankhwalawa amagwiritsidwa ntchito pawokha kapena kuphatikiza ndimankhwala ena omwe amapangidwa kuti achepetse shuga.
3. Njira yothetsera jakisoni simasakanizidwa kapena kuchepetsedwa ndi kukonzekera kwa insulin.
4. Mankhwalawa amagwira ntchito bwino pakhungu, motero sikulimbikitsidwa kuti mupeze jekeseni wamkati.
5. Wodwala akatembenukira ku insulin glargine, kuwunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira kwa masiku 14-21.

Pakusintha mankhwalawa, katswiri amasankha chiwembucho potengera deta yomwe wodwalayo akuwunika ndikusamala mawonekedwe a thupi lake. Kuzindikira kwa insulin kumawonjezeka pakapita nthawi chifukwa cha kusintha kwa kayendedwe ka metabolic, ndipo mlingo woyambirira wa mankhwalawo umakhala wosiyana. Kuwongolera kwa regimen ndikofunikanso kuti kusinthasintha kwa kulemera kwa thupi, kusintha kwa magwiridwe antchito, kusintha kwadzidzidzi kwakhalidwe, ndiye kuti, pali zinthu zomwe zingapangitse chidwi chachikulu kwambiri pakupanga shuga wambiri kapena wotsika shuga.

Kuchita ndi mankhwala ena

Kuphatikiza ndi mankhwala ena kumakhudza kagayidwe kachakudya kamene kamayenderana ndi shuga:

1. Mankhwala ena amalimbikitsa mphamvu ya Lantus. Izi zikuphatikiza ndi sulfonamides, salicylates, mankhwala ochepetsa mphamvu ya glucose, ACE ndi mao inhibitors.
2. Ma diuretics, sympathomimetics, proteinase inhibitors, antipsychotic amodzi, mahomoni - akazi, chithokomiro, etc. zimafooketsa zotsatira za insulin glargine.
3. Zakudya zamafuta a lithiamu, ma beta-blockers kapena kumwa mowa zimayambitsa zovuta - kuwonjezera kapena kufooketsa mphamvu ya mankhwalawa.
4. Kutenga pentamidine mogwirizana ndi Lantus kumabweretsa spikes m'magulu a shuga, kusintha kwakuthwa kuchokera pakuchepa kupita pakuwonjezeka.

Mwambiri, mankhwalawa amakhala ndi ndemanga zabwino. Kodi glulin ya insulin imawononga ndalama zingati? Mtengo wa ndalama m'magawo umachokera ku ruble 2500-4000.

Makhalidwe a analogues

Ngati sizotheka kugula Lantus, analogue imasankhidwa.

Monga insulin glargine, levemir imatenga nthawi yayitali. Komabe, mbiri ya wothandizirayo ndiyoterera komanso yosiyana kwambiri ndi ya Lantus.

Mankhwala amatengedwa ngati ali ndi matenda ashuga. Sizingatheke kupatsa Levemir amayi apakati, ana ochepera zaka ziwiri (malinga ndi zina, zaka zisanu ndi chimodzi). Zabwino - kutenga Levemir sizimapangitsa kuti wodwala azikula kwambiri. Ndi insulini iti yogwiritsa - Lantus kapena Levemir? Levemir ndi analogue yotsika mtengo ya Lantus, yomwe ili ndi ndemanga zotsutsana. Ngati mankhwalawo aperekedwa kwa wodwala ndi boma ndipo palibe zodandaula pakugwiritsa ntchito, kusankha kumawonekeratu. Kodi Levemir amalipira ndalama zingati pachipatala? Mtengo umasiyanasiyana kuchokera ku 300-500 mpaka 2000-300 rubles. kutengera mtundu wa kumasulidwa ndi kuchuluka kwa mabotolo. Ngati mungasankhe insulin lantus, mtengo wake udzakhala wokwera kwambiri.

Solostar ndi mndandanda wathunthu wa Lantus, womwe uli ndi katundu wofanana ndi contraindication. Mankhwalawa amalembera ana opitirira zaka 2. Ngati mungayerekeze insulin Lantus ndi Solostar, ndemanga za iwo zidzakhala zofanana. Kuti mupange chisankho, samalani ndi mtengo wa Solostar. Mtengo wa mankhwalawo ndi wabwino - kuchokera ku 400-500 mpaka 4000 rubles. kutengera luso la kapangidwe kazinthu ndi kuchuluka kwake.

Chifukwa chake, mfundo zazikulu zingapo. Kugwiritsa ntchito mankhwala kwa nthawi yayitali ndikosavuta, koma osakupatsani mankhwala nokha - uwu ndi mwayi woyenera wa dokotala. Mukazindikira kuchuluka kwa inshuwaransi ya Lantus, khalani ndi chidwi ndi mayendedwe ngati ndi oyenera kwa inu. Solostar si yoyipa kugwiritsa ntchito, koma yotsika mtengo.

Glargin 3.6378 mg, womwe umagwirizana ndi zomwe zili mu insulin ya anthu 100 IU.

Omwe amathandizira: m-cresol, zinc chloride, glycerol (85%), sodium hydroxide, hydrochloric acid, madzi ndi.

Gulu la zamankhwala komanso mankhwala: Insulin yokhala ndi nthawi yayitali

Insulin glargine ndi chithunzi cha insulin ya anthu. Kupezedwa ndi kubwezeretsanso kwa mabakiteriya a DNA amtundu wa Escherichia coli (tizilombo ta K12). Imakhala ndi solubility yochepa m'malo osalowerera ndale. Imasungunuka kwathunthu muzinthu za Lantus, zomwe zimatsimikiziridwa ndi chilengedwe cha acidic yankho la jakisoni (pH = 4). Pambuyo poyambitsa mafuta ochulukirapo, yankho, chifukwa cha acidity yake, limalowa mu mawonekedwe osakanikirana ndi mapangidwe a microprecipitates, pomwe ma insulin glargine amatulutsidwa nthawi zonse, ndikupereka chithunzi chosalala (chopanda).

Ma paramu omangira a insulin glargine ndi insulin ya anthu ali pafupi kwambiri. Insulin glargine imakhala ndi chilengedwe chofanana ndi insulin.

Chochita chofunikira kwambiri cha insulini ndikukhazikitsidwa kwa kagayidwe. Insulin ndi ma analogi ake amachepetsa shuga m'magazi ndikulimbikitsa kukoka kwa glucose pogwiritsa ntchito zotumphukira (makamaka mafupa a minofu ndi adipose minofu), pomwe tikuletsa mapangidwe a shuga mu chiwindi (gluconeogenesis). Insulin imalepheretsa adipocyte lipolysis ndi proteinol, pamene ikupanga kuphatikiza mapuloteni.

Kutalika kwa nthawi ya insulin glargine makamaka chifukwa cha kutsika kwake, komwe kumakupatsani mwayi wogwiritsa ntchito mankhwalawa nthawi 1 / tsiku. Kukhazikika kwa zochita kumachitika pafupifupi - pambuyo pa ola limodzi pambuyo pa utsogoleri wa sc. Kutalika kochedwa kwa maola ndi maola 24, kutalika kwambiri - maola 29. Chikhalidwe cha insulin ndi mawonekedwe ake (mwachitsanzo, insulin glargine) pakapita nthawi amatha kusiyanasiyana kwa odwala osiyanasiyana komanso kwa wodwala yemweyo.

Kutalika kwa mankhwala a Lantus kumachitika chifukwa cha kuyambitsidwa kwake mu mafuta akununkhira.

Kafukufuku wofananira wa kuzama kwa insulin glargine ndi insulin-isophan pambuyo pa sc pakuyamwa m'magazi a anthu athanzi ndi odwala omwe awululidwa pang'onopang'ono komanso kuyamwa kwakanthawi, komanso kusowa kwa kuchuluka kwa ndende mu insulin glargine poyerekeza ndi insulin-isofan.

Pamene / pakukhazikitsa mankhwala 1 nthawi / tsiku, khola la insulin glargine m'magazi limakwaniritsidwa patatha masiku 2-4 pambuyo pokhazikitsa mlingo woyamba.

Ndi on / kumayambiriro kwa T1 / 2 insulin glargine ndi insulin yaumunthu ikufanana.

Mwa munthu yemwe wakula mafuta osunthika, insulin glargine imakhazikika pang'ono kuchokera kumapeto kwa carboxyl (C-terminus) ya B unyolo (beta unyolo) kuti ipange 21A-Gly-insulin ndi 21A-Gly-des-30B-Thr-insulin. Mu plasma, onse insulin glargine osasinthika ndi zopangidwa ndi cleavage zilipo.

• 
  shuga mellitus wofuna chithandizo cha insulin mwa akulu, achinyamata ndi ana opitirira zaka 6.

Mlingo wachipangizocho ndi nthawi ya tsiku yoyang'anira imayikidwa payekhapayekha. Lantus amatumizidwa s / c 1 nthawi / tsiku nthawi zonse nthawi imodzi. Lantus iyenera kuyambitsidwa ndi mafuta ochulukirapo am'mimba, phewa kapena ntchafu. Masamba a jakisoni amayenera kusinthana ndi kuyambitsa kwatsopano kwa malonda omwe ali m'malo omwe akutsimikiziridwa kuti akuyang'anira.

Mtundu wa 1 wa matenda ashuga, mankhwalawo amagwiritsidwa ntchito ngati insulin yayikulu.

Mtundu wachiwiri wa matenda a shuga, mankhwalawa amatha kugwiritsidwa ntchito ngati mankhwala a monotherapy komanso kuphatikizira zinthu zina za hypoglycemic.

Posamutsa wodwala kuchokera ku insulin ya nthawi yayitali kapena yapakati kuti afike ku Lantus, pangafunikire kusintha tsiku ndi tsiku insulin kapena kusintha lingaliro la antidiabetic mankhwala (Mlingo ndi njira yothandizira makonzedwe achidule a insulin kapena zotengera zawo, komanso Mlingo wa mankhwala a hypoglycemic). Mukasamutsa wodwala kuchokera pakulidwe ka insulin-isophan kamodzi pa jekeseni imodzi ya Lantus, mlingo wa tsiku ndi tsiku wa insal insulin uyenera kuchepetsedwa ndi 20-30% m'milungu yoyamba yamankhwala kuti muchepetse chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri.Munthawi imeneyi, kuchepa kwa mulingo wa Lantus kuyenera kulipidwa ndi kuwonjezeka kwa Mlingo wa insulin yochepa, ndipo kumapeto kwa nthawi, mankhwalawa a mankhwalawa amayenera kusinthidwa payekhapayekha.

Monga ma fanizo ena a insulin yaumunthu, mwa odwala omwe amalandira Mlingo wambiri wa mankhwala chifukwa cha kupezeka kwa ma antibodies a insulin ya anthu, kusintha kwa mayankho a insulin kumawonedwa ndikusintha kwa Lantus. Mukusintha kupita ku Lantus komanso milungu yoyambirira pambuyo pake, kuyang'anira shuga wamagazi ndikofunikira.

Pofuna kusintha kwa kagayidwe kazinthu komanso kuwonjezereka kwa chidwi cha insulin, kuwongolera kwina kwa mankhwalawa kungakhale kofunikira. Kusintha kwa magazi kungafunikenso, mwachitsanzo, pakusintha kulemera kwamthupi la wodwalayo, momwe amakhalira, nthawi ya tsiku yopanga mankhwala, kapena pachitika zina zomwe zimawonjezera chidwi chakukula kwa hypo- kapena hyperglycemia.

Mankhwala sayenera kuperekedwa kwa iv. Mu / pakubweretsa njira yanthawi zonse, yomwe imapangidwira kukonzekera kwa sc, imatha kuyambitsa kukula kwa hypoglycemia.

Asanakhazikitsidwe, muyenera kuwonetsetsa kuti ma syringe alibe zotsalira zamankhwala ena.

Zotsatira zoyipa zomwe zimakhudzana ndi kagayidwe kazachilengedwe: zimayamba kumachitika nthawi zambiri ngati mlingo wa insulini uposa kufunika kwake.

Kuukira kwa hypoglycemia, makamaka kubwereza, kungayambitse kuwonongeka kwamanjenje. Zolemba za hypoglycemia zomwe zimatenga nthawi yayitali komanso zimatha kuwononga miyoyo ya odwala.

Zizindikiro za adrenergic anti-regulation (kutsegula kwa mtima wachifundo-adrenal poyankha hypoglycemia) nthawi zambiri zimayambitsa matenda a neuropsychiatric chifukwa cha hypoglycemia ("tadzulo" chikumbumtima kapena kutayika kwake, matenda osokoneza bongo): njala, kusokonekera, thukuta lakuzizira (kufalikira kwambiri komanso kwakula kwambiri kwa hypoglycemia, Zizindikiro zotchulidwa za adrenergic anti-regulation).

Kuchokera kumbali ya gawo la masomphenyawo: Kusintha kwakukulu mu kayendedwe ka shuga m'magazi kungayambitse kuwonongeka kwakanthawi chifukwa cha kusintha kwa minyewa ya tigor ndi cholozera cholocha cha mandala a maso.

Kutalika kwa nthawi yayitali kwamwazi wamagazi kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy. Poyerekeza ndi maziko a insulin mankhwala, limodzi ndi kusinthasintha kwa magazi m'thupi, kuwonjezereka kwakanthawi kwa matenda ashuga a retinopathy ndikotheka. Odwala omwe ali ndi prineticolin retinopathy omwe samathandizika kwambiri ndi matenda opatsirana, ma epicode kwambiri a hypoglycemia angayambitse kukula kwamawonedwe kwakanthawi.

Zomwe zimachitika mdera: monga mankhwala ena aliwonse a insulin, kuyamwa kwa insulin kungachedwetsedwe kwanuko. M'mayesero azachipatala panthawi ya insulin mankhwala ndi Lantus, lipodystrophy imawonedwa mu 1-2% ya odwala, pomwe lipoatrophy sichinali konse konse. Kusintha kosalekeza kwa malo a jekeseni mkati mwa thupi omwe amalimbikitsidwa kuti apangidwe ndi insulin kungathandize kuchepetsa kuopsa kwa izi kapena kupewa kukula kwake.

Thupi lawo siligwirizana: nthawi ya mayesero a chipatala panthawi ya mankhwala a insulin ogwiritsa ntchito Lantus, zimachitika zosagwirizana ndi jakisoni pamalo a jakisoni zimawonedwa mu 3-4% ya odwala - redness, kupweteka, kuyabwa, urticaria, kutupa kapena kutupa. Nthawi zambiri, zosankha zazing'ono zimathetsedwa kwakanthawi kwamasiku angapo mpaka masabata angapo.

Thupi lawo siligwirizana kwenikweni ndi mtundu wa insulin (kuphatikizapo insulin glargine) kapena mbali zina zothandizira, monga zotupa zapakhungu, angioedema, ochepa hypotension, mantha, osayamba. Izi zimatha kuopsa moyo.

Zina: kugwiritsa ntchito insulin kungayambitse kupanga kwa antibodies kwa izo. Panthawi ya mayesero azachipatala m'magulu a odwala omwe amathandizidwa ndi insulin-isofan ndi insulin glargine, mapangidwe a antibodies akuwombana ndi insulin yaumunthu amawonedwa pafupipafupi. Nthawi zina, kukhalapo kwa ma antibodies oterewa ku insulin kungapangitse kusintha kwa mankhwalawa kuti athetse chizolowezi cha chitukuko cha hypo- kapena hyperglycemia.

Nthawi zambiri, insulini imapangitsa kuti kuchepa kwa mankhwala a sodium ndi mapangidwe a edema, makamaka ngati insulini yowonjezereka imabweretsa kusintha kosasintha kwa kayendedwe ka metabolic.

• 
  ana ochepera zaka zisanu ndi chimodzi (pakadali pano palibe zambiri zakugwiritsa ntchito).
  
• 
  kusokonekera kwambiri kwa insulin glargine kapena chilichonse chothandiza pazogulitsa.

Samalani pogwiritsa ntchito Lantus panthawi yapakati.

Mimba komanso kuyamwa

Samalani mukamagwiritsa ntchito Lantus pa nthawi yapakati.

Kwa odwala omwe ali ndi vuto la matenda am'mbuyomu kapena gestational shuga, ndikofunikira kuti azikhala ndi nthawi yokwanira yogwiritsira ntchito metabolism. Munthawi yoyamba kubereka, kufunika kwa insulini kumatha kuchepa; muyezo wachiwiri ndi wachitatu, amatha kuchuluka. Mwana akangobadwa kumene, kufunika kwa insulini kumachepa, chifukwa chake chiopsezo cha hypoglycemia chimawonjezeka. Pansi pa izi, kuyang'anira shuga wamagazi ndikofunikira.

M'maphunziro oyesera a nyama, palibe deta yachindunji kapena yosalunjika yomwe idapezeka pa embryotoxic kapena fetotoxic of insulin glargine.

Panalibe mayeso azachipatala omwe amayang'anira chitetezo cha mankhwala a Lantus panthawi yapakati. Pali zambiri zakugwiritsa ntchito kwa Lantus mwa azimayi 100 oyembekezera omwe ali ndi matenda ashuga. Maphunziridwe ake ndi zotsatira za kutenga pakati pa odwalawa sizinasiyanane ndi zomwe zimachitika mwa amayi apakati omwe ali ndi matenda ashuga omwe amalandila mankhwala ena a insulin.

Mwa kuyamwa azimayi, mlingo wa insulini komanso kusintha kwa zakudya kungafunike.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Chifukwa chochepa ndi Lantus, sizinali zotheka kuwunika momwe ntchito yake imathandizira komanso chitetezo pochotsa odwala omwe ali ndi vuto la chiwindi.

Gwiritsani ntchito ntchito yolakwika yaimpso

Chifukwa chazochepera ndi Lantus, sizinali zotheka kuwunika momwe ntchito yake imathandizira komanso chitetezo pochiza odwala omwe ali ndi vuto lochepa kwambiri kapena aimpso.

Lantus sakhala choyenera kusankha pa matenda ashuga a ketoacidosis. Zikatero, iv ikulimbikitsidwa kuti ikhale ndi insulin yochepa.

Chifukwa chakucheperako ndi Lantus, sizinali zotheka kuwunika kuti magwiridwe ake ndi otetezeka pochiza odwala omwe ali ndi vuto la chiwindi kapena odwala omwe ali ndi vuto lochepa kwambiri kapena aimpso.

Odwala omwe ali ndi vuto laimpso, kufunika kwa insulini kumatha kuchepa chifukwa chakufooka kwa njira zake zowonongera. Kwa odwala okalamba, kuwonongeka pang'onopang'ono kwaimpso kungayambitse kuchepa kosafunikira kwa insulin.

Odwala omwe ali ndi vuto lalikulu la kuchepa kwa hepatic, kufunika kwa insulin kumatha kuchepetsedwa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis ndi biotransfform ya insulin.

Pankhani yoyendetsa bwino magawo a shuga m'magazi, komanso ngati pali chizolowezi chakhazikitso cha hypo- kapena hyperglycemia, musanapitirize kukonza mankhwala, ndikofunikira kuwunika kulondola kwa njira yothandizira, malo oyendetsera malonda ndi njira yoyendetsera bwino jakisoni. poganizira zinthu zonse zomwe zikugwirizana ndi vutoli.

Nthawi ya kukonzekera kwa hypoglycemia zimatengera mawonekedwe a omwe amagwiritsidwa ntchito chifukwa cha insulin, motero, angasinthe ndikusintha kwa regimen yothandizira.Chifukwa cha kuchuluka kwa nthawi yomwe imagwira ntchito Lantus, munthu ayenera kuyembekezera kuchepa kwa hypoglycemia usiku, pomwe mwina m'mawa kwambiri izi zitha kuchuluka.

Odwala omwe ma episode a hypoglycemia atha kukhala ndi kufunika kwamatenda, kuphatikiza ndi stenosis yayikulu yamitsempha yama ziwalo zam'mimba kapena ziwalo zamatumbo shuga wamagazi.

Odwala ayenera kudziwa momwe zinthu zomwe zimasinthira hypoglycemia zimasinthira, kukhala osatchulika kapenanso kusapezeka m'magulu ena omwe ali pachiwopsezo, monga:

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  odwala omwe asintha kwambiri magazi a shuga,
  
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  odwala omwe hypoglycemia imayamba pang'onopang'ono,
  
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  okalamba, - odwala neuropathy,
  
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  odwala omwe ali ndi shuga yayitali,
  
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  odwala omwe ali ndi mavuto amisala
  
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  odwala kulandira chithandizo chofanana ndi mankhwala ena.

Zochitika zoterezi zimatha kuyambitsa kukula kwa hypoglycemia (kutayika kwa chikumbumtima) wodwala asanadziwe kuti akupanga hypoglycemia.

Masewera a hemoglobin atakhala abwinobwino kapena kuchepa kwambiri, ndikofunikira kulingalira za mwayi wokhala ndi zigawo za hypoglycemia zomwe zimachitika mobwerezabwereza (makamaka usiku).

Kutsatira kwodalirika kwa mankhwala a dosing, zakudya, ndi zakudya, kugwiritsa ntchito bwino insulin, komanso kuwongolera kuyambika kwa zizindikiro za hypoglycemia kumathandizira kuchepetsa kwambiri chiopsezo cha hypoglycemia. Pamaso pa zinthu zomwe zimapangitsa chidwi cha hypoglycemia, makamaka kuyang'anitsitsa ndikofunikira, chifukwa kusintha kwa insulin kungafunike. Izi ndi monga:

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  Kusintha kwa malo makonzedwe a insulin,
  
• 
  kuchuluka kwa insulin (mwachitsanzo, mukamachotsa kupsinjika),
  
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  zolimbitsa thupi, zapamwamba kapena zotenga nthawi yayitali,
  
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  Matenda oyamba limodzi ndi kusanza, kutsekula m'mimba,
  
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  kuphwanya zakudya ndi zakudya,
  
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  adadula chakudya
  
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  kumwa mowa
  
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  matenda ena osavomerezeka a endocrine (mwachitsanzo, kuperewera kwa adenohypophysis kapena adrenal cortex),
  
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  chithandizo chamankhwala ena.

Mu matenda apakati, kuyamwa kwamphamvu kwa magazi pamafunika. Mwambiri, kusanthula kumachitika kuti pakhale matupi a ketone mumkodzo, ndipo insulin dosing imafunikira nthawi zambiri. Kufunika kwa insulin sikukula kawiri kawiri. Odwala omwe ali ndi matenda amtundu wa 1 ayenera kupitiliratu kudya zopatsa mphamvu, ngakhale mutangodya zochepa kapena osadya, komanso kusanza. Odwala awa sayenera kusiya kuperekera insulin.

Zizindikiro: hypoglycemia yayitali ndipo nthawi zina imawopseza moyo wa wodwalayo.

Chithandizo: Magawo a hypoglycemia wolimbitsa thupi nthawi zambiri amayimitsidwa ndi kumeza chakudya cham'mimba chambiri. Zingakhale zofunikira kusintha mtundu wa mankhwala, zakudya kapena zolimbitsa thupi.

Ndime za hypoglycemia yoopsa, yophatikizika ndi chikomokere, kukomoka kapena matenda amitsempha, amafunika kulowetsedwa kwamkati kapena glucagon, komanso kulowetsedwa kwa njira yokhazikika ya dextrose solution. Zakudya zamafuta nthawi yayitali komanso kuyang'aniridwa kwa akatswiri kungafunike, popezakuyambiranso kwa hypoglycemia ndikotheka chifukwa cha kuwoneka bwino kwa chipatala.

Mphamvu ya hypoglycemic ya insulin imapangidwira ndi mankhwala apakamwa a hypoglycemic, ACE, fibrate, disopyramids, MAO inhibitors, propoxyphene, salicylates ndi sulfonamides.

Mphamvu ya hypoglycemic ya insulin imachepetsedwa ndi GCS, diazoxide, diuretics, glucagon, estrogens, gestagens, phenothiazine, zotengeka zina, somatotropin, sympathomimetics (kuphatikiza epinephrine, terbutaline), mahomoni a chithokomiro, protease inhibitors, antipsychotic ena (eg., Ol.

Beta-blockers, clonidine, mchere wa lithiamu ndi ethanol amatha kuwonjezera komanso kufooketsa mphamvu ya hypoglycemic ya insulin.

Pentamidine imatha kuyambitsa hypoglycemia, kusintha nthawi zina ndi hyperglycemia.

Mothandizidwa ndi zinthu zomvera chisoni, monga beta-blockers, clonidine, guanfacine ndi zizindikiro za kutsutsana ndi adrenergic, atha kukhala kapena sangakhalepo.

Lantus sayenera kusakanikirana ndi mankhwala ena a insulin, ndi mankhwala ena aliwonse kapena kuchepetsedwa. Mukasakanikirana kapena kuchepetsedwa, mawonekedwe amachitidwe ake amatha kusintha pakapita nthawi, kuphatikiza, kusakanikirana ndi ma insulin ena kungayambitse mpweya.

Malo osungira ndi nthawi

Makatiriji a OptiClick ndi makatoni ama cartridge ziyenera kusungidwa kuti zisachitike ndi ana, mufiriji, kutentha kwa 2 ° mpaka 8 ° C. Kuti muteteze kuwunika, malonda amayenera kusungidwa m'makatoni ake omwe, osawuma. Onetsetsani kuti muli mumakina kuti musagonane ndi chipinda chaulere kapena mapaketi achisanu.

Pambuyo pakuyamba kugwiritsa ntchito, makatiriji ndi ma cartridge a OptiKlik ziyenera kusungidwa kuti zisafike kwa ana, kutetezedwa ndikuwala pamtunda wa osaposa 25 ° C. Kuti mutetezedwe kuchoka pakuwala, nyamayo iyenera kusungidwa m'mathumba ake omwe.

Moyo wa alumali wazomwe mungagwiritse ntchito polojekiti mu cartridge ndi OptiClick cartridge system ndi zaka 3.

Moyo wa alumali wazinthu zomwe mumapangidwa ndi makatiriji ndi makatoni ama cartridge mutatha kugwiritsa ntchito masabata anayi. Ndikulimbikitsidwa kuti tsiku loti lisungidwe kwazomwe zalembedwa kale zilembedwe.

Yang'anani!
Musanagwiritse ntchito mankhwalawa "Lantus (Lantus)" ndikofunikira kukaonana ndi dokotala.
Malangizowo amaperekedwa kuti mudziwe nokha "Lantus (Lantus) "Monga nkhaniyo? Gawani ndi anzanu pa malo ochezera a pa Intaneti:

Tulutsani mafomu ndi ma CD

Yothetsera subcutaneous makonzedwe a 100 PIECES / ml

3 ml ya yankho mu cartridge yamagalasi owoneka bwino. Katirijiyo amasindikizidwa kumbali imodzi ndi choletsa cha brkidutyl ndikuwombedwa ndi chipewa cha aluminium, inayo ndi brwaputyl plunger.

Pa ma cartridge 5 mu chovala cholumikizira kuchokera ku filimu ya polyvinyl chloride ndi zojambulazo za aluminium.

Pazithunzithunzi 1 zoyambirira pamodzi ndi malangizo ogwiritsira ntchito kuchipatala ndi zilankhulo zaku Russia, ikani bokosi.

Njira yothetsera jekeseni wa subcutaneous 100 PIECES / ml

10 ml yankho mumabotolo amtundu wamagalasi owoneka bwino, opanda khungu, otsekemera ndi ma chlorobutyl oyimitsa ndikugudubuka ndi zisoti zotayidwa ndi zotengera zoteteza zopangidwa ndi polypropylene.

Kwa botolo limodzi, limodzi ndi malangizo ogwiritsira ntchito zachipatala m'boma ndi zilankhulo zaku Russia, ikani bokosi lamatoni.

Moyo wa alumali

Zaka 2 (botolo), zaka zitatu (cartridge).

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa phukusi.

Insulin glargine ndi chithunzi cha insulin ya anthu. Kupezedwa ndi kubwezeretsanso kwa mabakiteriya a DNA amtundu wa Escherichia coli (tizilombo ta K12). Imakhala ndi solubility yochepa m'malo osalowerera ndale. Monga gawo lokonzekera kwa Lantus ®, imasungunuka kwathunthu, yomwe imatsimikiziridwa ndi chilengedwe cha acidic yankho la jakisoni (pH = 4). Pambuyo poyambitsa mafuta ochulukirapo, yankho, chifukwa cha acidity yake, limalowa mu mawonekedwe osakanikirana ndi mapangidwe a microprecipitate, pomwe ma insulin glargine amatulutsidwa nthawi zonse, ndikupereka chithunzi chosalala (chopanda).

Ma paramu omangira a insulin glargine ndi insulin ya anthu ali pafupi kwambiri. Glulin insulin imakhala ndi mphamvu yofanana ndi insulin.

Chochita chofunikira kwambiri cha insulini ndikukhazikitsidwa kwa kagayidwe ka glucose. Insulin ndi mawonekedwe ake amachepetsa shuga m'magazi ndikulimbikitsa kukoka kwa glucose pogwiritsa ntchito zotumphukira (makamaka mafupa a minofu ndi adipose minofu), komanso kuletsa mapangidwe a shuga mu chiwindi (gluconeogenesis). Insulin imalepheretsa adipocyte lipolysis ndi proteinol, pamene ikupanga kuphatikiza mapuloteni.

Kutalika kwa nthawi ya insulin glargine makamaka chifukwa cha kuchepa kwake, komwe kumapangitsa kuti mankhwalawa agwiritsidwe ntchito 1 nthawi / tsiku. Kukhazikika kwa pafupifupi ndi ola limodzi pambuyo pa sc makonzedwe. Kutalika kochedwa kwa maola ndi maola 24, kutalika kwake ndi maora 29. Chikhalidwe cha insulin ndi mawonekedwe ake (mwachitsanzo, insulin glargine) pakapita nthawi amatha kusiyanasiyana kwa odwala osiyanasiyana komanso kwa wodwala yemweyo.

Kutalika kwa mankhwalawa Lantus ® ndi chifukwa cha kuyambitsa kwake mu mafuta obisika.

Kafukufuku wofananira wa kutsindika kwa insulin glargine ndi insulin-isofan pambuyo pa sc pakubwera m'magazi a anthu athanzi komanso odwala matendawa adawonetsa kuyamwa pang'onopang'ono komanso kwa nthawi yayitali, komanso kusapezeka kwa nsonga ya insulin glargine poyerekeza ndi insulin-isofan.

Ndi s / c popereka mankhwala 1 nthawi / tsiku, khola la insulin glargine m'magazi limakwaniritsidwa patatha masiku 2-4 pambuyo pa mlingo woyamba.

Ndi on / kumayambiriro kwa T 1/2 insulin glargine ndi insulin yaumunthu ikufanana.

Mwa munthu wopeza mafuta ochepa, insulin glargine imakonzedwa pang'ono kuchokera kumapeto kwa carboxyl (C-terminus) ya B unyolo (beta unyolo) kupanga 21 A -Gly-insulin ndi 21 A -Gly-des-30 B -Thr-insulin . Mu plasma, onse insulin glargine osasinthika ndi zopangidwa ndi cleavage zilipo.

- matenda a shuga omwe amafunikira chithandizo cha insulin mwa akulu, achinyamata ndi ana opitilira zaka 6.

Mlingo wa mankhwalawa komanso nthawi yakatsiku la kasamalidwe ake imayikidwa payekhapayekha. Lantus ® imayendetsedwa s / c 1 nthawi / tsiku nthawi zonse nthawi imodzi. Lantus ® iyenera kuyambitsidwa ndi mafuta am'mimba, phewa kapena ntchafu. Masamba obaya jekeseni amayenera kusinthana ndi mankhwala atsopano aliwonse omwe ali m'malo omwe akutsimikiziridwa kuti mankhwalawo ndi othandizira.

Mankhwalawa angagwiritsidwe ntchito onse ngati monotherapy, komanso kuphatikiza ndi mankhwala ena a hypoglycemic.

Posamutsa wodwala kuchokera ku insulin ya nthawi yayitali kapena yapakati mpaka Lantus ®, zingakhale zofunikira kusintha tsiku ndi tsiku insulin kapena kusintha kachitidwe ka antidiabetic mankhwala (mulingo ndi njira yothandizira makonzedwe osakanikirana a insulin kapena mawonekedwe awo, komanso Mlingo wa mankhwala osokoneza bongo a hypoglycemic).

Mukasamutsa wodwala kuchokera pakulidwe ka insulin kawiri kawiri kulowa jekeseni imodzi ya Lantus, mlingo wa tsiku ndi tsiku wa basal insulin uyenera kuchepetsedwa ndi 20-30% m'milungu yoyamba yamankhwala kuti muchepetse chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri. Munthawi imeneyi, kuchepa kwa mulingo wa Lantus kuyenera kulipidwa ndi kuwonjezeka kwa Mlingo wa insulin yochepa, kenako ndikusintha kwa Mlingo wa mankhwala.

Monga ma fanizo ena a insulin yaumunthu, odwala omwe amalandira Mlingo wambiri wa mankhwala chifukwa cha kupezeka kwa ma antibodies kwa insulin ya anthu amatha kuwona kuwonjezeka kwa kuyankha kwa insulin pamene akusinthana ndi Lantus ®. Mukasinthira ku Lantus ® komanso milungu yoyambirira itatha, kuyang'anira shuga m'magazi ndikofunikira ndipo ngati pakufunika kuthandizidwa, mupeze mankhwalawa.

Pofuna kusintha kwa kagayidwe kazinthu komanso kuwonjezereka kwa chidwi cha insulin, kuwongolera kwina kwa mankhwalawa kungakhale kofunikira.Kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwala, moyo, nthawi ya tsiku yoperekera mankhwala, kapena ngati zinthu zina zikuwoneka kuti zikuwonjezera kukonzekera kwa hypo- kapena hyperglycemia.

Mankhwala sayenera kuperekedwa. Mu / pakubweretsa njira yanthawi zonse, yomwe imapangidwira kukonzekera kwa sc, imatha kuyambitsa kukula kwa hypoglycemia.

Asanakhazikitsidwe, muyenera kuwonetsetsa kuti ma syringe alibe zotsalira zamankhwala ena.

Malamulo ogwiritsira ntchito ndikugwiritsa ntchito mankhwalawa

OptiSet asanadzaze ma syringe pensulo

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi. Ma cholembera opanda kanthu a OptiSet sanapangidwe kuti agwiritsenso ntchito ndipo akuyenera kuwonongeka.

Popewa kutenga kachilomboka, cholembera chomwe chimakhala chodzaza ndi chida chokha chogwiritsidwa ntchito ndi wodwala m'modzi yekha ndipo sichingasamutsidwe kwa munthu wina.

Kugwira cholembera cha OptiSet Syringe

Pa ntchito iliyonse yotsatira, gwiritsani ntchito singano yatsopano. Gwiritsani masingano okha oyenera cholembera cha OptiSet.

Jekeseni iliyonse isanachitike, kuyesedwa koyenera kuyenera kuchitidwa nthawi zonse.

Ngati cholembera chatsopano cha OptiSet chikugwiritsidwa ntchito, kukonzekera kuyesa kugwiritsa ntchito kuyenera kuchitika pogwiritsa ntchito magawo 8 osankhidwa ndi wopanga.

Wosankha mlingo akhoza kuzunguliridwa mbali imodzi.

Osatembenuza wokonza mlingo (kusintha kwa mlingo) mutakanikiza batani loyambira jakisoni.

Wina akapaka jakisoni kwa wodwala, ayenera kusamalidwa mwapadera kuti apewe kuvulala mwangozi ndi matenda opatsirana.

Osamagwiritsanso ntchito cholembera cha sytige ya OptiSet yowonongeka, komanso ngati vuto lakukayikira likuwoneka.

Ndikofunikira kukhala ndi cholembera cha sytige yopumira ya OptiSet ngati mutayika kapena kuwonongeka kwa omwe mumagwiritsa ntchito.

Mukachotsa chipewa mu syringe cholembera, onetsetsani zomwe zili patsamba losungirako la insulin kuti zitsimikizire kuti ili ndi insulin yoyenera. Maonekedwe a insulini ayeneranso kufufuzidwa: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, lopanda zinthu zolimba zowoneka komanso lokhazikika monga madzi. Osagwiritsa ntchito cholembera cha sytinge ya OptiSet ngati njira ya insulin ndi yopanda mitambo, yothinitsidwa kapena yokhala ndi tinthu tachilendo.

Mukachotsa kapu, samalirani mosamala ndikulowetsa singano ndi cholembera.

Kuyang'ana kukonzeka kwa cholembera kuti mugwiritse ntchito

Pamaso pa jekeseni iliyonse, ndikofunikira kuyang'ana kukonzekera kwa cholembera kuti mugwiritse ntchito.

Kwa cholembera chatsopano chatsopano komanso chosagwiritsidwa ntchito, chizindikiro cha mankhwalawa chiyenera kukhala nambala 8, monga momwe zimapangidwira kale ndi wopanga.

Ngati cholembera chikagwiritsidwa ntchito, wopereka amayenera kuzunguliridwa mpaka chizindikiritso cha mankhwalawo chikuima nambala 2. Wowunikirawo azizungulira mbali imodzi yokha.

Kokani batani loyambira kwathunthu kuti mupeze mlingo. Osazungulira wosankha wa mankhwalawo mutatha batani loyambira litulutsidwe.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa. Sungani kapu yakunja kuti mupeze singano yogwiritsidwa ntchito.

Mukugwira cholembera ndi singano yoloza m'mwamba, ikani pang'onopang'ono zitsulo za insulini ndi chala chanu kuti thovu lakumwamba lithe kulunjika ku singano.

Pambuyo pake, dinani batani loyambira njira yonse.

Ngati dontho la insulin litulutsidwa kuchokera kunsonga ya singano, cholembera cha singano ndi singano chimagwira ntchito molondola.

Ngati dontho la insulin silikuwoneka pamphepete mwa singano, muyenera kubwereza kuyeserera kwa cholembera kuti mugwiritse ntchito mpaka insulin itaonekere kumapeto kwa singano.

Mankhwala a insulin

Mlingo wa mayunitsi 2 mpaka 40 ungayikidwe mu zowonjezera za 2 mayunitsi. Ngati mlingo wopitilira mayunitsi 40 ukufunika, uyenera kutumikiridwa pobayira ziwiri kapena zingapo. Onetsetsani kuti muli ndi insulin yokwanira muyezo wanu.

Mulingo wa insulin yotsalira pachidebe cha insulin imawonetsa kuchuluka kwa insulini yotsalira mu cholembera cha sytiitet ya OptiSet. Mlingowu sungagwiritsidwe ntchito kumwa mankhwala a insulin.

Ngati piston wakuda ali kumayambiriro kwa mzere wachikuda, ndiye kuti pali magawo 40 a insulin.

Ngati pisitoni wakuda ili kumapeto kwa mzere wachikuda, ndiye kuti pali magawo 20 a insulin.

Wosankha mlingo uyenera kutembenuzidwa mpaka muvi womwenso uwonetsa mlingo womwe ungafune.

Kumwa kwa insulin

Batani loyambira jekeseni liyenera kukokedwa mpaka kumalizira kuti mudzaze cholembera.

Ziyenera kuwunikidwa ngati mulingo wofunikira uli ndi zonse. Batani loyambira limasuntha molingana ndi kuchuluka kwa insulini yomwe yatsala mu thanki ya insulin.

Yambitsani batani limakupatsani mwayi kuti muone ngati ndiwomwe udayamwa. Mukamayesedwa, batani loyambira liyenera kupitilizidwa mphamvu. Mzere womaliza wowoneka bwino pabatani wayambira kuchuluka kwa insulin yomwe yatengedwa. Pokhazikitsa batani loyambira, pamwamba pamzerewu ndiwowoneka.

Ophunzitsidwa mwapadera ayenera kufotokozera wodwalayo njirayo.

Singano ndi jekeseni sc. Batani loyambira jekeseni liyenera kukanikizidwa mpaka pakufika. Kungodinanso kukusiyani pomwe batani la jekeseni litakankhidwa njira yonse. Kenako, batani loyambira jakisoni liyenera kusindikizidwa kwa masekondi 10 musanachotsere singano pakhungu. Izi zitsimikiza kukhazikitsidwa kwa mlingo wonse wa insulin.

Pakapita jakisoni aliyense, singano imayenera kuchotsedwa mu cholembera ndikuchotsa. Izi zimathandiza kupewa matenda, komanso kutayika kwa insulini, kudya kwa mpweya komanso kuthekera kwa singano. Singano sizingagwiritsenso ntchito.

Pambuyo pake, valani chipewa cha syringe cholembera.

Makatoni amayenera kugwiritsidwa ntchito limodzi ndi cholembera cha syringe ya OptiPen Pro1, komanso molingana ndi malingaliro omwe adaperekedwa ndi wopanga chipangizocho.

Malangizo ogwiritsira ntchito cholembera cha sytige ya OptiPen Pro1 okhudza kukhazikitsidwa kwa katiriji, zolumikizira singano, ndi jakisoni wa insulin ziyenera kutsatiridwa chimodzimodzi. Yenderani cartridge musanagwiritse ntchito. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe tizinthu totsimikizika tolimba. Asanakhazikitse cartridge mu syringe cholembera, cartridge iyenera kukhala pakupanda kutentha kwa maola 1-2. Musanalowetse jakisoni, chotsani thovu lakumtunda. Ndikofunikira kutsatira mosamalitsa malangizo. Makatoni opanda kanthu sagwiritsidwanso ntchito. Ngati cholembera cha sytiit ya OptiPen Pro1 chawonongeka, simuyenera kuchigwiritsa ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala posankha yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochita 100 IU / ml).

Optical Dinani Cartridge System

Pulogalamu yama cartridge ya OptiClick ndi kapu yagalasi yokhala ndi 3 ml ya insulin glargine solution, yomwe imayikidwa mu chidebe chowoneka bwino cha pulasitiki chomwe chili ndi zida za piston.

Dongosolo la cartridge la OptiClick liyenera kugwiritsidwa ntchito limodzi ndi cholembera cha sytinge ya OptiClick molingana ndi malangizo ogwiritsira ntchito omwe adabwera nawo.

Ngati cholembera cha sytiit ya OptiClick chawonongeka, chotsani ndi chatsopano.

Asanakhazikitse dongosolo la cartridge mu cholembera cha sytiit ya OptiClick, liyenera kukhala kutentha kwa firiji kwa maola 1-2. Njira yama cartridge iyenera kuyang'aniridwa isanayikidwe. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe zinthu zophatikizika.Pamaso jakisoni, thovu la mpweya liyenera kuchotsedwa mu dongosolo lama cartridge (lofanana ndi cholembera). Makina a cartridge opanda kanthu sagwiritsidwanso ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala polemba yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochitika 100 IU / ml).

Popewa matenda, munthu m'modzi yekha ndi amene ayenera kugwiritsa ntchito cholembera.

Kudziwitsa za pafupipafupi zoyipa: nthawi zambiri (≥ 10%), nthawi zambiri (≥ 1%, mankhwala

Chofunikira chachikulu pa mankhwalawa ndi insulin glargine, yomwe ili ndi kuchuluka kwa 3.6378 mg. Kutanthauziridwa kukhala insulin yaumunthu, kuchuluka kumeneku kumafanana ndi magawo 100 apadziko lonse lapansi. Kuphatikiza pazomwe zimagwira, mawonekedwe a mankhwalawa amaphatikizanso othandizira. Izi zikuphatikiza:

• metacresol
• nthaka ya chloride
• glycerol
• sodium hydroxide
• hydrochloric acid concentrate,
• madzi oyeretsedwa.

Odwala apadera

Magulu ena a odwala amafunikira chisamaliro chapadera posankha mankhwala ochizira. Kwa iwo, muyenera kuwerengera mosamala mankhwalawo ndikuwonetsetsa momwe mankhwalawo alili.

Odwala awa akuphatikizapo:

1. Achikulire . Ukalamba umabweretsa kusintha kwakukulu pakugwira ntchito kwa chiwalo chonse komanso ziwalo za munthu payekhapayekha. Mwa anthu opitilira 65, impso ndi chiwindi sizigwira ntchito komanso mwa achinyamata ambiri. Ndipo kuphwanya magwiridwe antchito awo kumayambitsa boma kwambiri. Chifukwa chake, kugwiritsa ntchito Lantus ndi odwalawa kumafunikira kusamalidwa kwa malamulo osamala. Amachepetsa mlingo wa mankhwalawa, amapenda magwiridwe antchito a impso ndi chiwindi, ndipo amayang'anira kuchuluka kwa shuga.
2. Ana . Kwa ana ochepera zaka 6, mankhwalawa amawonedwa ngati oletsedwa. Panalibe milandu yovulaza kuchokera ku izo, koma poti sizigwiritsidwa ntchito kwa odwala matenda ashuga ochepa. Kafukufuku wambiri pazotsatira zake pagulu la odwala nawonso sanachitepo.
3. Amayi oyembekezera . Potere, zovuta zimakhalapo pakusintha pafupipafupi kwa misinkhu ya shuga komwe kumalumikizidwa ndi nthawi. Ngati pakufunika chithandizo cha insulin, chimagwiritsidwa ntchito, koma magazi amayang'aniridwa nthawi zonse kuti ayang'anire shuga, ndikusintha gawo la mankhwalawa malinga ndi zotsatira zake.
4. Amayi oyamwitsa . Kwa iwo, chida ichi sichololedwa. Sizinakhazikitsidwe pepala lofufuza ngati Glargin adalowa mkaka wa m'mawere. Koma ngati ilowera, ndiye, malinga ndi madokotala, sizikhala zowopsa kwa khanda chifukwa cha mapuloteni ake. Njira zopewera kusamala ndi zotere zimaphatikizapo kusintha kwa mlingo ndi zakudya. Izi zimalepheretsa kukula kwa zizindikiro zoyipa.

Ndi zolemba za Lantus zomwe zatchulidwa, ndizotheka kupanga chithandizo ndi chithandizo chake kukhala chopindulitsa kwambiri komanso motetezeka.

M'mitundu iti

Insulin Lantus ndi madzi omwe mawonekedwe ake amafanana ndi madzi. Silopanda utoto, ndipo lakonzedwa kuti likhale loyang'anira. Mankhwala amapezeka m'mitundu itatu:

Lantus SoloStar ndi cholembera chopanda popanda singano, momwe ma cartridge agalasi odzaza ndi insulin solution amaikidwira. Makatoni amasindikizidwa mbali zonse, komwe kumachotsera mpweya kulowa munjira yake komanso kutayikira kwake.

Lantus Optiklik ndi dongosolo lama cartridge lomwe limawonetsedwa mumawonekedwe a makatiriji opangidwa ndigalasi lopanda utoto. Ma cartridge awa ndi oyenera kugwiritsidwa ntchito ndi cholembera cha sytige ya OptiClick.

Lantus OptiSet ndi syringe yocheperako yopanda makatiriji, omwe amadzazidwa ndi yankho pakapangidwe kamankhwala.

Mosasamala mawonekedwe a mankhwalawa amasulidwe, mphamvu zawo ndizofanana ndipo ndi 3 ml.

Zochita pa thupi

Lantus ndi wa gulu la mankhwalawa omwe ali ndi vuto lanthete. Pulogalamu yake yogwira, insulin glargine, idapezeka ndikusintha kwa DNA ya mabakiteriya amtundu wa Escherichia (K12 tizilombo), omwe ndi a Escherichia coli okhala nyama zamagazi ofunda m'matumbo apansi.

Izi sizingasungunuke m'malo osaloledwa. Mu kapangidwe kake ka mankhwalawa, kamasungunuka kwathunthu chifukwa cha hydrochloric acid, womwe umasunga acid acid m'malo.

Njira yothetsera vutoli imalowetsedwa m'mafuta amkati, momwe acidization imachitikira, yomwe imapangitsa kuti microprecipitate ipangidwe. Kuchita kotereku kumabweretsa kupangidwa kwa mpweya wabwino kwambiri, womwe umasungunuka pang'onopang'ono, ndikutulutsa magawo a insulin glargine. Mbali iyi ya mankhwalawa imakupatsani mwayi wokhala ndi shuga wokwanira m'magazi kwa nthawi yayitali, ndikuletsa kusintha kwakukulu pamlingo wake.

Insulin ndiye mahomoni ofunikira kwambiri omwe amawongolera kagayidwe kazinthu m'thupi, kupereka kusintha kwa glucose kukhala mphamvu. Nthawi yomweyo, ndikofunikira kwambiri kuti ma receptor omwe amapezeka m'maselo a minofu awone insulin kuchokera kunja, monga mahomoni opangidwa ndi kapamba. Ubwino wa insulin glargine ndikuti magawo ake ogwirira ntchito pazinthu za insulin ndi ofanana ndi insulin ya anthu.

Insulin, monga ma analogues, mosayang'ana komwe adachokera, amawongolera kagayidwe kazinthu monga:

• amathandizira kusintha kwa glucose kukhala glycogen m'chiwindi,
• kuchepetsa kuchuluka kwa shuga m'magazi am'magazi,
• perekani kugwidwa kwa shuga ndi kukonzedwa kwa minofu ya mafupa ndi minofu ya adipose,
• ziletsa kutembenuka kwa chiwindi cha glucose kuchokera m'mafuta ndi mapuloteni.

Insulin sikuti imangopereka mphamvu zokha, komanso imanganso yomwe imapereka mapangidwe a maselo atsopano. Katunduyu amaperekedwa ndi zotsatirazi:

• insulin imathandizira kupanga mapuloteni pogwiritsa ntchito minofu,
• amalepheretsa kuwonongeka kwa mapuloteni,
• zimathandizira kupanga mafuta, zimapatsa lipid metabolism yachilendo,
• zimakhudza maselo a minofu ya adipose, kupewa kuti mafuta asokonezeke.

Makhalidwe oyerekeza

Kuchita kafukufuku wofunafuna kuphunzira za insulin glargine, asayansi anazindikira kuti momwe thupi limagwirira ntchito ndi lofanana ndi insulin. Mitsempha yoyeserera ya zinthu izi pamlingo wofanana, zinapangitsa kuti zinthu zonse ziwiri zimathandizenso kagayidwe kazakudya. Ndipo kutalika kwa momwe zimakhudzira thupi la munthu kudalira zinthu zingapo, kuphatikizapo zolimbitsa thupi.

Komabe, zidadziwika kuti insulin glargine, yomwe idalowetsedwa m'mafuta osakanikirana, idachitapo kanthu pang'onopang'ono kuposa insulin ya munthu. Koma njira yotulutsira mahomoni idayenda bwino, zomwe zidaloleza kuti ikhudze thupi nthawi yayitali, osapangitsa kusintha kwadzidzidzi m'magazi a glucose m'magazi.

Makhalidwe abwino awa a insulin glargine amafotokozedwa ndikuchepetsa pang'onopang'ono, kotero kuti anthu odwala matenda a shuga amafunikira kamodzi kokha patsiku.

Nthawi yayitali ya insulin glargine ndi maola 24. Komabe, pazachipatala panali odwala omwe amafunikira kugwiritsa ntchito mankhwalawa maola 29 aliwonse.

Kugwiritsa ntchito mankhwalawa, monga zina zilizonse, ziyenera kumveka kuti nthawi yake yowonekera kwake imatengera mawonekedwe a thupi la munthu aliyense komanso zinthu zina zambiri.

Yemwe Insulin Lantus adasokonekera

Mankhwalawa alibe zotsutsana. Kupatula kokha ndi milandu yotsatirayi:

• Hypersensitivity mwina ndi insulin yokha kapena pazinthu zomwe zimapanga mankhwala,
• osakwana zaka 6.

Chithandizo cha amayi apakati chikuyenera kuchitika kokha moyang'aniridwa ndi dokotala.

Zotsatira zoyipa zomwe zingachitike

Zotsatira zoyipa kwambiri pakhungu la insulin glargine, monga mankhwala ena aliwonse a insulin, ndi hypoglycemia. Amayamba ngati mulingo wa mankhwalawo amawerengeredwa molakwika.

Popeza glucose ndiye amathandizira kwambiri maselo onse amthupi, kuphatikizapo ubongo, ndi kuchepa kwakukulu pamlingo wake m'magazi, dongosolo lamanjenje laumunthu limavutika makamaka. Izi ndichifukwa choti palibe nkhokwe za glycogen muubongo, zomwe zimapangitsa kuti maselo ake afe ndi mphamvu ndikukula kwa chikhalidwe chotchedwa neuroglycopenia.

Zotsatira zoyipa

Nthawi zambiri, zizindikiro za lipohypertrophy kapena lipodystrophy zimawonekera m'malo a jakisoni. Mosiyana ndi zinthu ziwiri izi, lipoatrophy imayamba nthawi zambiri. Kuti mupewe izi, ndikofunikira kuyambitsa jekeseni wina aliyense malo atsopano m'malo ovomerezeka a thupi.

Zochita zakomwe zimachitika ndi insulin nthawi zambiri zimatha. Amawonetsedwa pazowonetsera izi:

• ululu pamalo jakisoni,
• pakubwezeretsa pakhungu komwe kumayikidwa jakisoni nthawi zambiri,
• pakuwoneka kuti wapsinjika ndi kuyabwa,
• mu zotupa zimachitika malo jakisoni.

Komabe, mawonetseredwe onsewa, monga lamulo, amazimiririka pakapita nthawi atayamba kugwiritsa ntchito insulin Lantus.

Zotsatira zoyipa

Nthawi zambiri, mawonetsedwe otsatirawa amawonetsedwa mwa odwala:

• thupi lawo siligwirizana, zomwe zimawopseza thanzi komanso moyo wa wodwala.
• kuchepa kowoneka bwino ndi kuwonongeka kwa mawonekedwe,
• kutupa.

Momwe thupi limasokoneza zimachitika chifukwa chophwanya chitetezo cha mthupi. Zotsatira izi zitha kuchitika:

• anaphylactic shock,
• zotupa pakompyuta
• angioedema,
• kulephera kupuma
• kutsitsa magazi ndi ena.

Kuchepa kwa kuwona kwakukongola ndi kuwonongeka kwa mawonekedwe, monga lamulo, ndizakanthawi ndipo kumachitika chifukwa cha kuchepa kwa shuga m'magazi komwe kumayambira kumbali ya hyperglycemia yayitali. Ngati sanalandiridwe, izi zitha kuchititsa kuti masomphenyawo asamaoneke.

Kukhazikitsidwa kwa insulin Lantus kumatha kuyambitsa kuphwanya kwamchere wamchere wamchere, ndikupangitsa kuwoneka kwa edema. Komabe, chiwonetserochi ndichakanthawi.

Komanso sizotheka kuchita insulin Lantus, yotchulidwa pakupanga mankhwala osokoneza bongo. Pankhaniyi, kuphatikizika kwamtanda kumachitika pakati pa insulin yopangidwa ndi kapamba ndi insulin yomwe imayendetsedwa kuchokera kunja. Komanso, izi zimawoneka osati Lantus zokha, komanso mankhwala ena aliwonse a insulin.

Kupanga kwa ma antibodies kungayambitse kukula kwa onse hypoglycemia ndi hyperglycemia. Chifukwa chake, odwala nthawi zambiri amafunikira kusintha kwa Lantus.

Zotsatira zoyipa kwambiri

Insulin glargine ingayambenso mavuto ena omwe amakhala osowa kwambiri. Izi zikuphatikiza:

• dysplasia - mkhalidwe kuti pankhaniyi akufotokozedwa mu kupotoza kukoma,
• myalgia - matenda omwe amapezeka chifukwa cha kuwonjezeka kwa kamvekedwe ka minofu.

Lantus insulin yoyendetsera njira

Musanagwiritse ntchito insulin Lantus, malangizo ogwiritsira ntchito ayenera kuphunziridwa mosamala. Tiyenera kukumbukira kuti mankhwalawa amaletsedwa kulowetsedwa m'mitsempha, chifukwa amatha kupangitsa kukula kwa mitundu yayikulu ya hypoglycemia.

Mutha kubayira mbali zotsatirazi zathupi:

• pakhoma pamimba,
• kulowa mumsempha wokhathamira
• kulowa ntchafu.

Pochita maphunziro, panalibe kusiyana pakati pa kuphatikizira kwa insulin m'malo osiyanasiyana a thupi.

Mankhwala Insulin Lantus SoloStar amapezeka momwe momwe makatiriji okhala ndi yankho la insulin amapangidwira. Imatha kugwiritsidwa ntchito. Potere, yankho litatha, chogwirira chimayenera kutayidwa.

Mankhwala Insulin Lantus OptiKlik ndi cholembera cha syringe chomwe chimagwiritsidwa ntchito mobwerezabwereza pambuyo pokhazikitsa katoni yakale ndi watsopano.

Zomwe zimagwiritsidwa ntchito ndi insulin Lantus

Kumbukirani kuti sizingatheke kuyimitsa yankho la insulin kapena kusakaniza ndi mankhwala ena okhala ndi insulin, chifukwa pamenepa nthawi yomwe mankhwalawa akhudzana ndi thupi la wodwalayo idzaphwanyidwa. Kuphatikiza apo, ndikasakanizidwa ndi mankhwala ena mu njira ya Lantus, mpweya wabwino ungapangike.

Kusungabe kuchuluka kwa shuga m'magazi, ndikokwanira kuperekera mankhwalawa kamodzi patsiku limodzi. Komanso, nthawi ya tsiku siyofunika kwambiri.

Mlingo wa mankhwalawa komanso nthawi yomwe makonzedwe ake akuyenera kuwerengedwa ndi dokotala aliyense payekha kwa wodwala aliyense.

Chithandizo cha matenda osagwirizana ndi insulin omwe amadalira matenda a shuga amatha kuchitika ndi kuphatikiza kwa insulin Lantus ndi mankhwala a antiidiabetes.

Tiyenera kukumbukira kuti mwa anthu azaka zopitilira 65 pamakhala kuchepa kwa impso, zomwe zimapangitsa kuti insulin ichedwe. Chifukwa chake, kufunikira kwawo kwa insulin kumachepetsedwa kwambiri.

Kuchepetsa mlingo wa mankhwalawa umafunika kwa odwala omwe ali ndi vuto la chiwindi. Mwa odwala, mapangidwe a glucose ochokera m'mafuta ndi mapuloteni amawatsekedwa, ndipo njira ya mayamwidwe ya insulin imachepetsedwa kwambiri.

Mlingo kusintha kwa mankhwala okhala ndi insulin glargine ndi kofunikira mu milandu ina. Izi zikuphatikiza:

• kusintha kwa odwala
• kusintha kwa moyo
• kufunika kosintha nthawi yokonzekera mankhwala,
• ngati kumayambiriro kwa mankhwala mavuto obwera omwe angayambitse kukula kwa hypo- kapena hyperglycemia.

Musanagwiritse ntchito koyamba, ndikofunikira kuphunzira mosamala malangizo omwe wopanga amapangira mankhwalawo. Muyeneranso kuyang'ana momwe yankho liliri: liyenera kukhala lowonekera kwathunthu popanda zodetsa.

Tiyenera kukumbukira kuti mankhwalawa amapangidwa mwanjira yothetsera, chifukwa chake safuna kuchepetsedwa ndi kusakanikirana.

Zoyenera kuchita vuto la bongo

Mlingo wowerengeka molakwika wa mankhwalawa ungayambitse kukula kwambiri kwa hypoglycemia, chithandizo chomwe chiyenera kuchitika pang'onopang'ono. Ndi mtundu wa hypoglycemia wocheperako, kudya michere yosavuta kungathandize wodwala.

Woopsa milandu, odwala angafunike kubayidwa kudzera m'mitsempha kapena glucose yothandizidwa kudzera m'mitsempha.

Kuchita ndi mankhwala ena

Mankhwala ena amatha kuthana ndimatenda a shuga ndi insulin, omwe angafune kusintha kwa mankhwalawo komanso kusintha kwa muyezo wa Lantus insulin.

Kukonzekera kwotsatira kwamankhwala kungapangitse kwambiri zotsatira za insulin glargine:

• mankhwala antipyretic mankhwala:
• mankhwala omwe amalepheretsa zochitika za ACE,
• Disopyramide - mankhwala omwe amasintha kugunda kwa mtima,
• Fluoxetine - mankhwala ogwiritsidwa ntchito pamavuto akulu,
• kukonzekera komwe kumapangidwa pamaziko a fibroic acid,
• mankhwala omwe amaletsa ntchito ya monoamine oxidase,
• Pentoxifylline - mankhwala a gulu la angioprotectors,
• Propoxifene ndi mankhwala osokoneza bongo osokoneza bongo,
• salicylates ndi sulfonamides.

Mankhwala otsatirawa amatha kufooketsa zochita za insulin glargine:

• ma anti-kutupa mahomoni omwe amachepetsa chitetezo cha mthupi,
• Danazol - mankhwala omwe ali m'gulu la mankhwala ena a androgens,
• Diazoxide
• mankhwala okodzetsa
• mankhwala okhala ndi analogi ya estrogen ndi progesterone,
• kukonzekera komwe kwapangidwa pamaziko a phenothiazine,
• mankhwala omwe amalimbitsa kapangidwe ka norepinephrine,
• mawonekedwe a mahomoni a chithokomiro.
• Kukonzekera kokhala ndi analogue yachilengedwe kapena yokumba,
• antipsychotropic mankhwala
• proteinase zoletsa.

Palinso mankhwala ena omwe zotsatira zake sizikudziwika. Amatha kufooketsa mphamvu ya insulin glargine ndikuyipangitsa. Mankhwalawa ndi monga:

• B-blockers
• kuthamanga kwa magazi komwe kumachepetsa mankhwala
• mchere wa lithiamu
• mowa

Moyo wa alumali ndi mawonekedwe osungira

Kugwiritsa ntchito mankhwala Lantus insulin glargine saloledwa zosaposa zaka 3 kuyambira tsiku lomwe amasulidwe. Mwanjira iyi, cartridge lotseguka ndi loyenera kugwiritsidwa ntchito kwa masabata anayi. Chifukwa chake, tsiku lotsegulira liyenera kuwonetsedwa pa zilembo zake.

Kutentha kwambiri kwa mankhwalawo ndi 2-8 ° C. Izi zikutanthauza kuti muyenera kusungira Lantus insulin mufiriji. Komabe, musanagwiritse ntchito, cholembera cha syringe pamodzi ndi cartridge ziyenera kusungidwa kutentha kwa maola angapo.

Siloledwa kumasula yankho. Ndipo mutatsegula cartridge, muyenera kuyisunga osapitilira milungu 4 pamalo otetezedwa ndi dzuwa. Komabe, siyiyenera kuyikidwa mufiriji.

Zoyang'ana?

Mukamagwiritsa ntchito mankhwalawa, muyenera kusamala pantchito yomwe imafuna chisamaliro komanso kulondola. Pankhani ya kukula kwa chikhalidwe cha hypoglycemic, wodwalayo amatha kukhudzidwa ndi kuchuluka kwa momwe angachitire komanso kuthekera kwambiri.

Chenjezo liyeneranso kuchitidwa kwa odwala matenda ashuga omwe ali ndi vuto la chiwindi ndi impso. Chiwindi chimakhudzidwa ndi mankhwala okhala ndi insulin - amachepetsa kuchuluka kwa shuga.

Ndi kulephera kwa chiwindi, shuga amaphatikizidwa pang'onopang'ono komanso popanda zovuta zapadera. Mothandizidwa ndi Lantus, kuperewera kwa shuga kungachitike, komwe ndi kowopsa kwa anthu. Chifukwa chake, ndikofunikira kwa odwala kuti achepetse kuchuluka kwa insulin, kuyang'ana kwambiri kuopsa kwa matendawa.

Impso zimagwira nawo gawo limodzi pazinthu zomwe zimagwiritsidwa ntchito popanga mankhwala ndi metabolic. Ngati awonongeka ndipo sagwira ntchito mokwanira, ndiye kuti zimakhala zovuta kwambiri kuti athetse insulini yoyenera. Chifukwa chotsika kwambiri pazandale, chinthucho chimadzunjikira m'thupi, kuchepetsa kwambiri shuga, chomwe chimakhala chowopsa pakukula kwa boma la hypoglycemic.

Momwe mungalowere?

Mankhwalawa amadziwika ndi nthawi yayitali, motero, ndikofunikira kuyisankha kuposa, mwachitsanzo, ena a Lantus insulin analogues. Amalandira odwala omwe amadwala matenda a shuga omwe amadalira insulin, ndipo sikuti ndi mtundu woyamba wa matenda.

Ma analogi odziwika bwino omwe amachotsa insulin Lantus ndi -, Humalog, ndi Apidra.

Lantus, monga fanizo lina la insulin, limayendetsedwa ndi jekeseni wa subcutaneous. Cholinga sichinapangidwe kuti athandizidwe kukonzekera mtsempha.

Mukanyalanyaza lamuloli ndikulidziwitsa, mutha kupangitsa kuti kuchitika kwa hypoglycemia. Iyenera kuyambitsidwa ndi mafuta m'mimba, mapewa kapena matako.

Ndikofunika kuti musaiwale kuti simungabaye jakisoni wa insulin pamalo amodzi, chifukwa izi ndizopangika ndikupanga hematomas.

Ma analogi a Lantus, ngati iyemwini, siwoyimitsidwa, koma yankho lowonekera kwathunthu.

Ndikofunika kufunsa dokotala wanu za kugwiritsa ntchito mankhwalawo osagwiritsa ntchito mankhwalawo, koma mawonekedwe ake otchuka, omwe ali ndi zotsatira zofanana.

Kukhazikika kwa zochita za Lantus ndi ena ofanana nawo kumawonedwa ndendende ola limodzi, ndipo kutalika kwa chikoka kuli pafupifupi tsiku limodzi. Koma, nthawi zina imatha kukhala ndi zotsatira zosatha kwa maola makumi awiri ndi zisanu ndi zinayi, kutengera mlingo womwe umayendetsedwa - izi zimakuthandizani kuti muiwale za jakisoni wa tsiku lonse.

Pofuna kuthana ndi chiwonetsero choyipa cha matenda ashuga, akatswiri amapereka mankhwala a Lantus ndi mawonekedwe ake otchuka. Kwazitali kwambiri, mankhwalawa mwapang'onopang'ono adadziwika ndipo pakadali pano amadziwika kuti ali oyamba pakulimbana ndi kuphwanya kwa dongosolo la endocrine.

Maubwino angapo a mahomoni opanga ma pancreatic:

1. Ndiwothandiza kwambiri ndipo imachepetsa mawonetsero a matenda ashuga,
2. ili ndi mbiri yabwino kwambiri yachitetezo,
3. yosavuta kugwiritsa ntchito
4. mutha kulunzanitsa jakisoni wa mankhwala ndi chinsinsi chake cha mahomoni.

Ma analogi a mankhwalawa amasintha nthawi yowonetsedwa ndi mahomoni amunthu pancreatic kuti apereke njira yothandizira pamankhwala ndikutonthoza kwakukulu kwa wodwala yemwe ali ndi vuto la endocrine.

Mankhwalawa amathandizira kukwaniritsa muyeso wolondola pakati pa zoopsa za kutsika kwa shuga wamagazi ndikukwaniritsa mulingo wa glycemic.

Pakadali pano, pali mitundu ingapo yamomwe imafanana ndi mahomoni amtundu wa kapamba wa munthu:

• ultrashort (Humalog, Apidra, Novorapid Penfill),
• nthawi yayitali (Lantus, Levemir Penfill).

Mankhwala okhalitsa a Lantus Solostar, nawonso - Tresiba amadziwika kuti ndiodziwika kwambiri.

Lantus kapena Tresiba: zili bwino?

Poyamba, muyenera kuganizira za aliyense payekhapayekha. Mankhwala othandizira omwe amapezeka Tresiba ndi insulin degludec. Monga Lantus, ndi analogue of the pancreatic homoni. Chifukwa cha ntchito yopweteka kwambiri ya asayansi, mankhwalawa adalandiranso zinthu zapadera.

Kuti apange, ma biotechnologies apadera a DNA omwe adapangidwanso adagwiritsidwa ntchito ndikuphatikizira gawo la Saccharomyces cerevisiae, ndipo mawonekedwe a maselo a insulin a anthu adasinthidwa.

Pakadali pano, mankhwalawa amatha kugwiritsidwa ntchito ndi odwala, omwe ndi oyamba komanso achiwiri a shuga. Ndikofunikira kudziwa kuti ili ndiubwino wina poyerekeza ndi ma insulin ena, omwe alipo ambiri.

Malinga ndi malonjezo opanga, palibe hypoglycemia iyenera kuchitika pogwiritsa ntchito mankhwala a Tresib. Palinso mwayi wina wa mankhwalawa: kusinthika kocheperako pamlingo wa glycemia masana. Mwanjira ina, pamankhwala ochiritsira omwe mumagwiritsa ntchito mankhwala a Tciousba, m'magazi a shuga mumakhala maola makumi awiri ndi anayi.

Uwu ndi mwayi wamtengo wapatali kwambiri, chifukwa kugwiritsa ntchito analogue ya Lantus kumakupatsani mwayi woti musaganize za insulin osati masana, komanso usiku.

Koma chida ichi chili ndi phindu limodzi: sizikulimbikitsidwa kuti zigwiritsidwe ntchito ndi anthu ochepera zaka khumi ndi zisanu ndi zitatu, amayi apakati komanso oyembekezera. Sizingathe kutumikiridwa ndi jakisoni wamkati. Kugwiritsa ntchito kwapansipansi kokha ndi kololedwa.

Ponena za Lantus, zabwino zake zonse zafotokozedwa pamwambapa. Koma ngati titha kufanana pakati pa ma insulin, titha kunena kuti kuchuluka kwa hemoglobin kumatsika kwakukulu ndikugwiritsa ntchito mankhwala a Tresib kuposa Lantus.Ndiye chifukwa chake kufanana kwa zinthu zomaliziraku nkothandiza kwambiri.

Popeza, mwatsoka, Lantus anathetsedwa, ndikofunikira kuti odwala a endocrinologists omwe ali ndi matenda onse a shuga atenge malo a insulin omwe amatchedwa Tresiba.

Makanema okhudzana nawo

Opanga Lantus sakhala mdziko limodzi, koma awiri - Germany ndi Russia. Itha kugulidwa ku malo ena ogulitsa, koma posachedwapa ma analogi ake kapena chophatikizika chokha chimagwiritsidwa ntchito nthawi zambiri. Izi ndichifukwa choti posachedwapa mankhwalawo akhala ovuta kwambiri kupeza. Ku Lantus, njira yachilatini nthawi zambiri imawoneka motere: "Lantus 100 ME / ml - 10 ml".

Kuchiza kwambiri pogwiritsa ntchito mankhwalawa kumatha kupititsa patsogolo thanzi labwino ndikuwongolera glycemia mwa anthu onse omwe ali ndi matenda ashuga. Ndikofunikira kuyandikira phwando mosamala kuti pasakhale zovuta zina. Onetsetsani kuti mukutsatira mlingo womwe dokotala wakupatsani kuti mupewe zovuta zosiyanasiyana komanso zovuta zomwe mungagwiritse ntchito.

Lantus ndi mankhwala osokoneza bongo ogwiritsidwa ntchito pochiza matenda ashuga.