Momwe mungagwiritsire ntchito mankhwala Tsiprolet 500?

Mankhwala "Tsiprolet 500" amatanthauza mankhwala a antibacterial ndipo amaphatikizidwa ndi gulu la fluoroquinolones. Amapangidwira zochizira matenda opatsirana omwe amachititsa microflora chidwi ndi mankhwalawa. Chidacho chili ndi ntchito yayikulu komanso kuthamanga.

Achire zotsatira za mankhwala "Tsiprolet 500"

Mankhwalawa amasokoneza kupanga kabakiteriya wa DNA, potero amaphwanya magawo awo ndi kukula. Mankhwalawa ndi othandizadi pochiza matenda omwe amachititsa mabakiteriya osagwiritsa ntchito gramu (salmonella, E. coli, Klebsiella, Shigella). Mankhwalawa amakhudzanso ma gram okhala ndi ma gramu okhala ndi mphamvu (streptococci, staphylococci). Chidachi chimagwiritsidwa ntchito pochiza ma pathologies omwe amayamba chifukwa cha mphamvu ya ma microbes amkati (chlamydia, tuberculous mycobacteria). Mankhwalawa amathandizanso pochiza matenda oyambitsidwa ndi Pseudomonas aeruginosa. Ciprolet 500 imapangidwa ngati mapiritsi omwe ali ndi chophatikizira 0,5 magalamu. Palinso mapiritsi okhala ndi voliyumu yaying'ono yamtunduwu (250 mg). Kumasulidwa ndi yankho la kulowetsedwa. Zofanizira zamankhwala ndi Siflox, Ciprinol, Ciprofloxacin.

Zizindikiro zogwiritsidwa ntchito

Mankhwala "Tsiprolet 500" amagwiritsidwa ntchito pochiza matenda a khutu, mmero, mphuno, komanso kupuma. Kugwiritsidwa ntchito kwake kwa chibayo komwe kwayambitsidwa ndi staphylococci, hemophilic bacilli, legionella, Klebsiella, enterobacter kwawonetsedwa. Mothandizidwa ndi mankhwalawa, matenda a mucous membrane, ma ducts a bile, kugaya chakudya, khungu, maso, minofu yofewa, ziwalo zoberekera, kuthandizira minofu ndi mafupa. Imwani mapiritsi a sepsis, peritonitis, prostatitis, pelvioperitonitis, adnexitis.

Zotsatira za mankhwala "Tsiprolet 500"

Sizoletsedwa kugwiritsa ntchito mankhwalawa panthawi yapakati, ana ochepera zaka zambiri, amayi oyamwitsa, omwe ali ndi hypersensitivity. Amagwiritsa ntchito mankhwala mosamala pazovuta zaubongo, kulephera kwa impso, ndi chiwindi, matenda amisala, komanso khunyu. Ndikosayenera kupereka mankhwala kwa okalamba.

Zotsatira zoyipa

Mukamagwiritsa ntchito mankhwalawa, zotsatira zoyipa monga psychosis, diplopia, kuyerekezera zinthu zina, tinnitus, kumva kutopa, kuwonjezeka kwa nkhawa, kupweteka mutu, komanso kusowa tulo. Ziwalo zam'mimba zimagwiritsa ntchito mapiritsi omwe ali ndi matenda otsegula m'mimba, kugona, kugona, kusanza, kupweteka kwam'mimba ndi mseru. Mankhwalawa, hypotension, tachycardia, cholestatic jaundice, kupweteka kwa minofu ndi minyewa, kugwedezeka kwa anaphylactic, urticaria, khungu rede komanso kuyabwa.

"Tsiprolet 500": malangizo ogwiritsira ntchito

Mapiritsi amatengedwa musanadye, osambitsidwa ndi madzi ambiri. Mlingo umatengera kuuma kwa matenda, m'badwo wa wodwalayo ndi thupi lake. Zochizira matenda a chinzonono, tengani piritsi limodzi layprolet (500 mg). Voliyumu yomweyo imagwiritsidwa ntchito pochiza matenda ovuta kwamikodzo, prostatitis, matenda am'mimba, osteomyelitis, enterocolitis.

Kutulutsa mawonekedwe ndi kapangidwe kake

Ciprolet imapezeka mu mitundu yotsatsira:

• Mapiritsi okhala ndi filimu: biconvex, yozungulira, yokhala ndi mawonekedwe osalala mbali zonse, pafupifupi oyera kapena oyera, kuwundana kwake kumakhala koyera kapena koyera (zidutswa 10 mu matuza, 1 kapena matuza awiri pamtolo wa makatoni),
• Njira yothetsera kulowetsedwa: chikasu chopepuka, chowoneka bwino, chopanda utoto (100 ml uliwonse mumabotolo a polyethylene otsika, botolo limodzi mu bokosi la makatoni),
• Maso akutsikira: wowonekera, wachikaso wopepuka kapena wopanda utoto (5 ml aliyense m'mabotolo opopera, botolo limodzi mu mtolo wa makatoni).

Piritsi limodzi lili ndi:

• Zogwira ntchito: ciprofloxacin - 250 kapena 500 mg (mu mawonekedwe a ciprofloxacin hydrochloride monohydrate - 291.106 kapena 582.211 mg, motero),
• Zothandiza monga (250/500 mg, motsatana): wowonda wa chimanga - 50.323 / 27,789 mg, cellcrystalline cellulose - 7.486 / 5 mg, talc - 5/6 mg, croscarmellose sodium - 10/20 mg, colloidal silicon dioxide - 5/5 mg, magnesium stearate - 3.514 / 4.5 mg,
• Filimu sheath (250/500 mg, motsatana): polysorbate 80 - 0.08 / 0,072 mg, hypromellose (6 cps) - 4.8 / 5 mg, titanium dioxide - 2 / 1.784 mg, sorbic acid - 0,08 / 0,072 mg Macrogol 6000 - 1.36 / 1.216 mg, talc - 1.6 / 1.784 mg, dimethicone - 0,08 / 0,072 mg.

Kapangidwe ka 100 ml yankho la kulowetsedwa kumaphatikizapo:

• Zogwira ntchito: ciprofloxacin - 200 mg,
• Zothandiza monga: sodium chloride - 900 mg, disodium edetate - 10 mg, lactic acid - 75 mg, citric acid monohydrate - 12 mg, sodium hydroxide - 8 mg, hydrochloric acid - 0,0231 ml, madzi a jekeseni - mpaka 100 ml.

The 1 ml ya madontho amaso akuphatikizapo:

• Zogwira ntchito: ciprofloxacin - 3 mg (mu mawonekedwe a ciprofloxacin hydrochloride - 3,49 mg),
• Zothandiza monga: disodium edetate - 0,5 mg, hydrochloric acid - 0,20034 mg, sodium kolorayidi - 9 mg, benzalkonium chloride 50% yankho - 0.0002 ml, madzi a jekeseni - mpaka 1 ml.

Zizindikiro zogwiritsidwa ntchito

Ciprolet mwa mapiritsi ndi njira yothetsera kulowetsedwa imayikidwa pochiza matenda opatsirana komanso otupa omwe amayamba chifukwa cha tizilombo tating'onoting'ono ta zochita za ciprofloxacin, kuphatikizapo:

• Matenda amtundu, kupuma kwamatumbo, kwamikodzo ndi impso, ziwalo za ENT, zimbudzi za ndulu, chikhodzodzo, khungu, minofu yofewa komanso mucous membrane, minofu ndi mafupa, minyewa yam'mimba (kuphatikizapo mano, pakamwa, nsagwada)
• Peritonitis
• Sepsis.

Mankhwalawa amagwiritsidwanso ntchito pochiza ndi kupewa matenda opatsirana omwe ali ndi kuchepetsedwa chitetezo chokwanira (panthawi yogwiritsira ntchito immunosuppressants).

Misozi ya Diso Waprolet imayikidwa matenda opatsirana ndi kutupa kwa diso ndi zina zake zoyambitsidwa ndi mabakiteriya omwe akhudzidwa ndi momwe mankhwalawo akuphatikizira.

• Blepharitis, blepharoconjunctivitis,
• Conjunctivitis (subacute ndi pachimake),
• Zilonda zam'magazi,
• Dacryocystitis ndi meibomite,
• Keratoconjunctivitis ndi bakiteriya keratitis.

Madonthanso amasonyezedwanso properative prophylaxis ndi kuchiza kwa matenda a postoperative opatsirana ophthalmosurgery komanso chifukwa cha zovuta za maso pambuyo pakulowetsa matupi achilendo kapena kuvulala (chithandizo ndi kupewa).

Contraindication

• Virtual keratitis (yamatsitsi amaso),
• Pseudomembranous colitis (mapiritsi ndi njira yothetsera kulowetsedwa),
• Glucose-6-phosphate dehydrogenase akusowa (chifukwa cha kulowetsedwa),
• Zaka mpaka 1 chaka (chamatsitsi amaso) kapena mpaka zaka 18 (mapiritsi ndi njira yothetsera kulowetsedwa).

Contraindication yamitundu yonse yamasulidwe:

• Mimba komanso kuyamwa
• Hypersensitivity pazigawo za mankhwala kapena mankhwala ena kuchokera ku gulu la fluoroquinolones.

Mosamala, Tsiprolet iyenera kutumikiridwa mu mitundu yonse ya Mlingo kwa odwala omwe ali ndi vuto lalikulu la mitsempha yamatumbo, ngozi zam'magazi komanso matenda osokoneza bongo.

Mkati komanso mkati mwa mankhwalawa, mankhwalawa amayenera kugwiritsidwa ntchito mosamala odwala okalamba, komanso khunyu, matenda amisala, kuthana kwambiri kwa hepatic komanso / kapena aimpso.

Mlingo ndi makonzedwe

Mlingo wa Ciprolet umatsimikiziridwa ndi mawonekedwe a kumasulidwa kwa mankhwalawa, kuopsa kwa matendawa, mtundu wa matenda, mkhalidwe wamthupi, kulemera kwa thupi, zaka komanso momwe zimagwirira ntchito kwa impso.

Ciprolet mu mawonekedwe a mapiritsi amatengedwa pakamwa, pamimba yopanda kanthu, ndi madzi ambiri.

Monga lamulo, dongosolo lotsatira la mankhwala limayikidwa:

• Matenda osavuta a kwamikodzo ndi impso, matenda am'munsi kupuma mwamphamvu: 2 kawiri pa tsiku, 250 mg aliyense, pamavuto akulu matendawa, mlingo umodzi ungakulire 2 times,
• Gonorrhea: 250-500 mg kamodzi,
• Matenda amadzimadzi, enteritis ndi colitis omwe ali ndi koopsa komanso kutentha thupi, prostatitis, osteomyelitis: 2 kawiri pa tsiku, 500 mg aliyense (pochizira matenda am'mimba otsogola, kumwa kamodzi kumachepetsedwa 2 times).

Kutalika kwa mankhwalawa kumatsimikizika ndi kuwopsa kwa matendawa, komabe, Ciprolet iyenera kutengedwa kwa masiku ena awiri atatha zizindikiro za matenda. Nthawi zambiri, kutalika kwa maphunzirowa ndi masiku 7-10.

Ngati aimpso kuwonongeka, 1 /₂ Mlingo wa mankhwala.

Mu kulephera kwa aimpso, Mlingo watsimikiza umapangidwa ndi creatinine chilolezo:

• Kuposa 50 ml pa mphindi imodzi: mulingo woyenera
• 30-50 ml pa mphindi: Nthawi imodzi mu maola 12, 250-500 mg aliyense,
• 5-29 ml pa mphindi: kamodzi pa maola 18, 250-500 mg.

Odwala omwe akutsatiridwa ndi hemo- kapena peritoneal dialysis amaperekedwa kamodzi pa maola 24 ali ndi 250-500 mg (pambuyo pa dialysis).

Ciprolet mwa njira yothetsera kulowetsedwa imayendetsedwa kudzera mu minyewa kwa mphindi 30 (200 mg iliyonse) ndi mphindi 60 (400 mg iliyonse).

Yankho la kulowetsedwa likugwirizana ndi yankho la Ringer, 0,9% sodium chloride solution, 10% solution ya fructose, 5% ndi 10% dextrose solution, komanso yankho lomwe lili ndi 5% dextrose solution yokhala ndi 0,45% kapena 0,2525% sodium chloride solution.

Pakati pokhapokha pali 200 mg (chifukwa cha matenda oopsa - 400 mg), pafupipafupi makonzedwe - 2 kawiri pa tsiku. Kutalika kwa mankhwala kutsimikiza kuopsa kwa matendawa ndi kuchuluka kwa masiku 7 mpaka 14. Ngati ndi kotheka, mankhwalawa amatha kugwiritsidwa ntchito kwa nthawi yayitali.

Mankhwala a gonorrhea pachimake, limodzi mtsempha wama 100 mg ya yankho akuwonetsedwa.

Pofuna kupewa matenda a postoperative, Ciprolet imayendetsedwa pamitsempha ya 200-400 mg 30-60 mphindi asanachitidwe opareshoni.

Cyprolet mu mawonekedwe a madontho a maso imagwiritsidwa ntchito kwambiri.

Ngati mankhwalawa ali ndi matenda owopsa komanso ofatsa, maola anayi aliwonse, madontho awiri a 2 amathandizidwa ndi gawo lamkati la diso lakhudzidwa, m'malo ovuta kwambiri, 2 imagwera ola lililonse. Pambuyo pakusintha, pafupipafupi ma instillation ndi mlingo amachepetsedwa.

Mankhwalawa bakiteriya zilonda zotupa:

• Tsiku loyamba: mphindi 15 zilizonse, dontho limodzi kwa maola 6, kenako mphindi 30 zilizonse pakudzutsa, dontho limodzi,
• Tsiku lachiwiri - ola lililonse nthawi yakudzuka, dontho limodzi,
• Tsiku la 3-14 - maola 4 aliwonse panthawi yovuta kwambiri, dontho limodzi.

Ngati 14 masiku chithandizo epithelization sichinachitike, chithandizo chitha kupitilizidwa.

Zotsatira zoyipa

Pogwiritsa ntchito Ciprolet mkati komanso mkati mwamitsempha, zotsatirazi zimabweretsa:

• Mtima dongosolo: mtima arrhythmias, tachycardia, kutsitsa magazi, kuthamanga kwa nkhope,
• Urinary system: interstitial nephritis, hematuria, crystalluria (makamaka yotsika okodzetsa ndi mkodzo wamchere), glomerulonephritis, polyuria, dysuria, albuminuria, kwamikodzo posungira, urethral magazi, kuchepa kwa impso yam'mimba,
• Njira ya minofu ndi mafupa: kupindika kwa tendon, arthralgia, tendovaginitis, nyamakazi, myalgia,
• Hematopoietic dongosolo: thrombocytosis, granulocytopenia, leukopenia, thrombocytopenia, anemia, leukocytosis, hemolytic anemia,
• Matumbo dongosolo: anorexia, kupweteka kwam'mimba, nseru, kusanza, kutsegula m'mimba, kuphwanya kwamchiberekero, cholestatic jaundice (makamaka odwala omwe ali ndi matenda am'mbuyomu), hepatonecrosis, hepatitis, kuchuluka kwa hepatic transaminases ndi alkaline phosphatase,
• Mitsempha yam'mimba: mutu, chizungulire, kugwedezeka, kutopa, kugona tulo, zovuta za m'mimba, zotumphukira paralgesia (anomaly mu malingaliro a kupweteka), kuchuluka kwazovuta zamkati, thukuta, nkhawa, kukhumudwa, kusokonezeka, kuyerekezera zinthu zina, komanso mawonekedwe ena amtundu wa psychotic. amatha kupita kumadera omwe wodwalayo amatha kudzivulaza), kukomoka, migraine, ubongo
• Ziwalo zomvekera bwino: kutaya makutu, tinnitus, kununkhira ndi kuwawa, kuwonongeka kwa mawonekedwe (diplopia, kusintha kwa mawonekedwe amitundu),
• Zizindikiro zasayansi: hypercreatininemia, hypoprothrombinemia, hyperglycemia, hyperbilirubinemia,
• Thupi lawo siligwirizana: kuwoneka kuwoneka zazing'ono zazingʻono ndi matuza limodzi ndi magazi, kuyabwa pakhungu, kutentha kwa mankhwalawa, urticaria, hemorrhages (petechiae), vasculitis, kupindika kwa pakhungu kapena nkhope epermermal necrolysis (matenda a Lyell), a Stevens-Johnson syndrome (woipa wankhanza wa erythema),
• Zina: kufooka wamba, superinfection (candidiasis, pseudomembranous colitis).

Ndi makonzedwe amtsempha, zimachitika zakumalo zimatha kuchitika, zowonetsedwa ndi kupweteka ndi kuwotcha pamalo a jekeseni, kukula kwa phlebitis.

Mukamagwiritsa ntchito Ciprolet ngati madontho amaso, mavuto otsatirawa akhoza kukhala:

• Gulu la masomphenya: Kuwotcha, kuyabwa, kuchepa kwa mtima, komanso kufatsa kwa mtima wa khunyu, kusowa kwa khungu, kutupira m'maso, kuchepa kwa thupi, kutulutsa thupi kwakunja m'maso, kuchepa kuwona kwakukongola, mawonekedwe amtundu wamkati wam'mimba,
• Zina: mseru, thupi lawo siligwirizana, kawirikawiri - kukulira kwa superinfection, chosasangalatsa pambuyo pake pakamwa pakangophunzitsidwa.

Malangizo apadera

Odwala omwe ali ndi khunyu, mbiri ya kukomoka, matenda am'mitsempha komanso kuwonongeka kwa ubongo chifukwa chakuwopseza zotsatira zoyipa kuchokera ku dongosolo lalikulu lamanjenje amayenera kupatsidwa Ciprolet mkati chifukwa cha thanzi lokha.

Ngati mankhwalawa atagwiritsidwa ntchito kapena atatha, kutsegula m'mimba kwa nthawi yayitali kapena m'mimba kwambiri, ndikofunikira kupatula kukhalapo kwa pseudomembranous colitis, komwe kumafunikira kuchoka kwa Ciprolet ndi kukhazikitsidwa kwa chithandizo choyenera. Kuchiza kuyenera kusiyidwa ndi kukula kwa zopweteka m'misempha kapena kuwonekera kwa zizindikiro zoyambirira za tenosynovitis.

Pogwiritsa ntchito mankhwalawa monga mapiritsi ndi njira yothetsera kulowetsedwa, madzi okwanira ayenera kuperekedwa poyang'ana diuresis yachilendo.

Diso latsika la Ciprolet lingagwiritsidwe ntchito kokha mwapadera, ndizosatheka kubaya mankhwalawo m'chipinda cham'maso cha diso kapena subconjunctival. Mukamagwiritsa ntchito mankhwalawa komanso njira zina zogwiritsira ntchito ma ophthalmic, gawo pakati pazoyang'anira liyenera kukhala osachepera mphindi 5. Kuvala magalasi osavomerezeka sikulimbikitsidwa panthawi yamankhwala.

Mukamagwiritsa Tsiprolet, chisamaliro chimayenera kuthandizidwa poyendetsa ndikugwira ntchito zina zowopsa zomwe zimafunikira chidwi chachikulu komanso kuthana ndi psychomotor mwachangu (makamaka kuphatikiza ndi mowa).

Kuyanjana kwa mankhwala

Panthawi yomwe Ciprolet angagwiritse ntchito nthawi yomweyo mankhwala ena osokoneza bongo, zotsatira zoyipa zingachitike:

• Didanosine: kuchepa mayamwidwe a ciprofloxacin,
• Theophylline: kuwonjezeka kwa kuchuluka kwake m'madzi am'magazi komanso chiopsezo chokhala ndi poizoni.
• Maantacidid, komanso kukonzekera komwe kumakhala ndi zinc, aluminium, magnesium kapena ayoni ayoni: kuchepetsedwa kuyamwa kwa ciprofloxacin (nthawi yomwe amagwiritsidwa ntchito ndi mankhwalawa iyenera kukhala osachepera maola 4),
• Maanticoagulants: nthawi yayitali yotuluka,
• Cyclosporin: kuchuluka nephrotoxicity,
• Mankhwala omwe amaletsa kutupa (kupatula acetylsalicylic acid): chiwopsezo cha kugwidwa,
• Metoclopramide: mayamwidwe othamanga a ciprofloxacin,
• Kukonzekera kwa uricosuric: Kuchedwa kuchotsedwa ndikuwonjezeka kwa plasma ndende ya ciprofloxacin,
• Ma anticoagulants osadziwika: kuwonjezera zochita zawo.

Pogwiritsa ntchito munthawi yomweyo Ciprolet ndi mankhwala ena oletsa kuponderezana, mgwirizano wogwirizana ungatheke. Kutengera ndi matendawa, Ciprolet itha kugwiritsidwa ntchito limodzi ndi mankhwala otsatirawa:

• Azlocillin, ceftazidime: matenda oyambitsidwa ndi Pseudomonas spp.,
• Meslocillin, azlocillin ndi mankhwala ena a beta-lactam: matenda a streptococcal,
• Isoxazolylpenicillins ndi vancomycin: matenda a staph,
• Metronidazole, clindamycin: matenda a anaerobic.

Ciprolet kulowetsedwa ndi mankhwala osagwirizana ndi mankhwala ndi mayankho onse kulowetsedwa omwe ali osakhazikika pamankhwala acid (pH ya kulowetsedwa kwa ciprofloxacin ndi 3.5-4.6). Ndizosatheka kusakaniza njira yothetsera mtsempha wamkati ndi njira zomwe pH imaposa 7.