Insulin Humulin: ndemanga, malangizo, kuchuluka kwa mankhwalawa

Mu 1 ml. Mankhwala a Humulin Humulin ali ndi 100 IU ya insulin. Zosakaniza ndi 30% insulin yosungunuka ndi 70% insulin isofan.

Monga momwe othandizira amagwiritsidwa ntchito:

• metacresol
• phenol
• sodium hydrogen phosphate heptahydrate,
• hydrochloric acid,
• glycerol
• zinc oxide
• protamine sulfate,
• sodium hydroxide
• madzi.

Kutulutsa Fomu

Kukonzekera kwa insulin Humulin M3 insulini imapezeka mu mawonekedwe a kuyimitsidwa kwa ma subcutaneous makonzedwe mu 10 ml mbale, komanso 1.5 ndi 3 ml makatoni, oikidwa m'mabokosi a 5 zidutswa. Cartridges adapangidwa kuti azigwiritsa ntchito syringes ya Humapen ndi BD-pen.

Mankhwala ali ndi hypoglycemic.

Humulin M3 amatanthauza mankhwala obwerezabwereza a DNA, insulin ndi kuyimitsidwa kwa jekeseni kawiri ndi nthawi yayitali.

Pambuyo mankhwala, mankhwala kukonzekera kumachitika pambuyo 30-60 Mphindi. Kuchuluka kwake kumatenga maola awiri mpaka 12, kutalika kwa zotsatirazi ndi maola 18-24.

Ntchito za humulin insulin zimatha kusiyanasiyana malinga ndi malo omwe mankhwalawo amaperekedwera, kulondola kwa mlingo wosankhidwa, zochita za thupi, wodwala, zina ndi zina.

Zotsatira zazikulu za Humulin M3 zimagwirizana ndi kayendedwe ka kusintha kwa shuga. Insulin ilinso ndi anabolic. Pafupifupi minofu yonse (kupatula ubongo) ndi minofu, insulin imayendetsa kayendedwe ka glucose ndi amino acid, komanso imayambitsa kuthamanga kwa protein anabolism.

Insulin imathandizira kusintha glucose kukhala glycogen, komanso imathandizira kusintha shuga yambiri kukhala mafuta ndikuletsa gluconeogeneis.

Zizindikiro zogwiritsidwa ntchito ndi zoyipa

1. Shuga mellitus, momwe insulin tikulimbikitsidwa.
2. Matenda a gestational (shuga ya amayi apakati).

1. Kukhazikika hypoglycemia.
2. Hypersensitivity.

Nthawi zambiri pa mankhwala akukonzekera insulin, kuphatikiza Humulin M3, kukula kwa hypoglycemia kumawonedwa. Ngati ili ndi mawonekedwe owopsa, imatha kupangitsa kuti mukhale ndi vuto la hypoglycemic (kukhumudwa komanso kusazindikira) komanso kungapangitse wodwalayo kuti afe.

Mwa odwala ena, thupi lawo siligwirizana, kuwoneka pakuluma pakhungu, kutupa ndi kufupika kwa malo a jakisoni. Nthawi zambiri, matendawa amadzidzidzikira okha patatha masiku kapena milungu yochepa atayamba chithandizo.

Nthawi zina izi sizimalumikizana ndi kugwiritsa ntchito mankhwalawo pawokha, koma ndi chifukwa cha mphamvu ya zinthu zakunja kapena jakisoni wolakwika.

Pali ziwonetsero zomwe sizigwirizana ndi zachilengedwe. Amachitika kawirikawiri, koma zowopsa. Ndi malingaliro otere, zotsatirazi zimachitika:

• kuvutika kupuma
• kuyamwa kofananira
• kugunda kwa mtima
• dontho mu kuthamanga kwa magazi
• kupuma movutikira
• thukuta kwambiri.

Milandu yoopsa kwambiri, chifuwa chimatha kusokoneza moyo wa wodwalayo ndipo imafunikira chithandizo chamankhwala chodzidzimutsa. Nthawi zina insulin m'malo kapena desensitization chofunika.

Mukamagwiritsa ntchito insulin ya nyama, kukana, hypersensitivity kwa mankhwala, kapena lipodystrophy imayamba. Mukamapereka insulin Humulin M3, kuthekera kwa zotulukazi ndi pafupifupi zero.

Malangizo ogwiritsira ntchito

Insulin ya Humulin M3 saloledwa kuti iperekedwe kudzera m'mitsempha.

Popereka mankhwala a insulin, muyezo ndi mtundu wa makonzedwe ungasankhidwa ndi dokotala. Izi zimachitika payekhapayekha kwa wodwala aliyense payekhapayekha, kutengera mtundu wa glycemia m'thupi lake. Humulin M3 idapangidwa kuti ikwaniritse maulamuliro a subcutaneous, koma amathanso kutumikiridwa intramuscularly, insulin ilola izi. Mulimonsemo, wodwala matenda ashuga ayenera kudziwa momwe angabayire insulin.

Pang'onopang'ono, mankhwalawa amalowetsedwa pamimba, ntchafu, phewa kapena matako. Mu malo omwewo jakisoni sangaperekedwe mopitilira kamodzi pamwezi. Panthawi ya njirayi, ndikofunikira kugwiritsa ntchito zida za jakisoni moyenera, kuti singano isalowe m'mitsempha yamagazi, kuti musamayesere malo a jakisoni pambuyo pobayira.

Humulin M3 ndi osakaniza wopangidwa ndi Humulin NPH ndi Humulin Regular. Izi zimapangitsa kuti asakonzekere yankho lisanayambike kwa wodwalayo.

Kukonzekera insulin ya jakisoni, cartridge ya Humulin M3 kapena NPH iyenera kukukhidwira maulendo 10 mmanja mwanu, ndikutembenuka madigiri a 180, gwedezani pang'onopang'ono kuchokera mbali ndi mbali. Izi zikuyenera kuchitika mpaka kuyimitsidwa kumakhala ngati mkaka kapena kukhala kwamtambo, ndimadzi amodzimodzi.

Kugwedeza mwachangu insulin NPH sikulimbikitsidwa, chifukwa izi zimatha kuyambitsa mawonekedwe a thovu ndikusokoneza kuchuluka kwake. Osagwiritsa ntchito mankhwalawa pogwiritsa ntchito matope kapena mapepala opangidwa mutasakaniza.

Makulidwe a insulin

Kuti mupeze jakisoni moyenera mankhwalawo, muyenera kuchita njira zina zoyambirira. Choyamba muyenera kudziwa malo omwe jakisoniyo, sambitsani manja anu bwino ndikupukuta malowa ndi nsalu yothinidwa ndimowa.

Kenako muyenera kuchotsa kapu yoteteza ku singano ya syringe, kukonza khungu (kutambasula kapena kutsina), ikani singano ndikupanga jakisoni. Kenako singano iyenera kuchotsedwa ndipo masekondi angapo, osafunikira, kanikizani tsamba la jekeseni ndi chopukutira. Pambuyo pake, mothandizidwa ndi kapu yakunja yoteteza, muyenera kumasula singano, kuichotsa ndikubwezeranso chipewacho.

Simungagwiritse ntchito singano yemweyo ya syringe kawiri. Vial kapena cartridge imagwiritsidwa ntchito mpaka itapanda kanthu, ndiye kuti imatayidwa. Ma cholembera a syringe adapangira kuti azigwiritsa ntchito payekha.

Bongo

Humulin M3 NPH, monga mankhwala ena omwe ali mgululi, samazindikira mopitirira muyeso, popeza kuchuluka kwa shuga m'magazi a seramu kumadalira kayendetsedwe kazinthu pakati pa msinkhu wa glucose, insulin ndi njira zina za metabolic. Komabe, bongo wa insulin yambiri imatha kukhala ndi zotsatirapo zoyipa kwambiri.

Hypoglycemia imayamba chifukwa cha kusamvana pakati pa zomwe zili ndi insulin m'magazi a plasma ndi mtengo wake wamphamvu komanso kudya.

Zizindikiro zotsatirazi ndizodziwika za hypoglycemia:

• ulesi
• tachycardia
• kusanza
• thukuta kwambiri,
• kukopa kwa pakhungu
• kunjenjemera
• mutu
• chisokonezo.

Nthawi zina, mwachitsanzo, ndi mbiri yayitali ya matenda a shuga kapena kuyang'anitsitsa kwake, Zizindikiro za kutha kwa hypoglycemia zimatha kusintha. Hypoglycemia yofatsa imatha kupewedwa pakutenga shuga kapena shuga. Nthawi zina mungafunikire kusintha kuchuluka kwa insulini, kuunikanso zakudya kapena kusintha zolimbitsa thupi.

Hypoglycemia wolimbitsa thupi nthawi zambiri amathandizidwa ndi subcutaneous kapena mu mnofu makonzedwe a glucagon, akutsatira mwa kumeza chakudya. Woopsa milandu, pamaso pa vuto la minyewa, kukomoka kapena chikomokere, kuwonjezera pa jakisoni wa glucagon, kugwirizira kwa glucose kuyenera kuperekedwa mwachangu.

M'tsogolomu, pofuna kupewa kufikanso kwa hypoglycemia, wodwalayo ayenera kudya zakudya zopatsa thanzi. Mikhalidwe yayikulu kwambiri ya hypoglycemic imafuna kuchipatala mwadzidzidzi.

Zochita Zamankhwala NPH

Kugwiritsa ntchito kwa Humulin M3 kumatheka chifukwa chokhala ndi mankhwala amkamwa a hypoglycemic, ethanol, zotumphukira za asidi wa asidi, zotsekemera za monoamine oxidase, sulfonamides, ACE inhibitors, angiotensin II receptor blockers, osasankha beta-blockers.

Mankhwala a Glucocorticoid, mahomoni okula, pakamwa pobayira, danazole, mahomoni a chithokomiro, thiazide diuretics, beta2-sympathomimetics amatsogolera kuchepa kwa mphamvu ya hypoglycemic ya insulin.

Limbitsani kapena, mutafooketsa kudalira insulin yomwe imatha lancreotide ndi ma analogu ena a somatostatin.

Zizindikiro za hypoglycemia zimatsitsidwa ndikutenga clonidine, reserpine ndi beta-blockers.

Migwirizano yogulitsa, yosunga

Humulin M3 NPH imapezeka pa pharmacy pokhapokha ngati mwalandira mankhwala.

Mankhwalawa amayenera kusungidwa pamtunda wa madigiri 2 mpaka 8, sangathe kuwundana ndikuwonetsa kuwala kwa dzuwa ndi kutentha.

Vial yotseguka ya NPH imatha kusungidwa pamawonekedwe a 15 mpaka 25 kwa masiku 28.

Kutengera ndi kutentha kofunikira, kukonzekera kwa NPH kumasungidwa zaka 3.

Malangizo apadera

Kuchotsera chithandizo mosavomerezeka kapena kuikidwa pakulakwika (komwe kumakhala kofunika kwambiri kwa odwala omwe amadalira insulin) kungayambitse kukula kwa matenda ashuga a ketoacidosis kapena hyperglycemia, omwe angawononge moyo wa wodwalayo.

Mwa anthu ena, mukamagwiritsa ntchito insulin yaumunthu, zizindikiro za hypoglycemia zomwe zikubwera zimatha kusiyana ndi zomwe zimadziwika ndi insulin yakuchokera kwa nyama, kapena zimatha kuwonetsa modekha.

Wodwalayo ayenera kudziwa kuti ngati shuga ya m'magazi imasintha (mwachitsanzo, ndi insulin Therapy), ndiye kuti zisonyezo zomwe zikutanthauza kuti hypoglycemia ikhoza kutha.

Mawonetsedwe awa amatha kuchepera mphamvu kapena kuwonekera mosiyanasiyana ngati munthu atenga mankhwala a beta-blockers kapena ali ndi matenda osokoneza bongo a nthawi yayitali, komanso pamaso pa matenda a shuga.

Ngati hyperglycemia, monga hypoglycemia, siinakonzedwenso munthawi yake, izi zitha kuchititsa kuti musakhale ndi chikumbumtima, chikomokere, komanso ngakhale kufa kwa wodwalayo.

Kusintha kwa wodwala kupita ku insulin ina ya insulin kukonzekera kapena mitundu yawo iyenera kuchitika kokha moyang'aniridwa ndi dokotala. Kusintha kwa insulin kukhala mankhwala okhala ndi zochitika zina, njira yopangira (DNA recombinant, nyama), mitundu (nkhumba, analog) ingafune mwadzidzidzi kapena, m'malo mwake, kusintha kosavuta kwa Mlingo wokhazikitsidwa.

Ndi matenda a impso kapena chiwindi, kusakwanira kwa ntchito ya pituitary, kugwira ntchito kwa minyewa ya adrenal ndi chithokomiro cha chithokomiro, kufunikira kwa insulin kumatha kuchepa, komanso kupsinjika mwamphamvu ndi zina zina, m'malo mwake, kumawonjezeka.

Wodwala nthawi zonse ayenera kukumbukira mwayi wokhala ndi hypoglycemia ndikuwunika bwino momwe thupi lake limayendetsa galimoto kapena kufunika kwa ntchito yoyipa.

• Monodar (K15, K30, K50),
• Novomix 30 Flexspen,
• Ryzodeg Flextach,
• Humalog Remix (25, 50).
• Gensulin M (10, 20, 30, 40, 50),
• Gensulin N,
• Rinsulin NPH,
• Farmasulin H 30/70,
• Humodar B,
• Vosulin 30/70,
• Vosulin N,
• Mikstard 30 NM
• Protafan NM,
• Humulin.

Mimba komanso kuyamwa

Ngati mayi woyembekezera ali ndi matenda ashuga, ndiye kuti ndikofunikira kwambiri kuti azilamulira glycemia. Pakadali pano, zofuna za insulin nthawi zambiri zimasintha nthawi zosiyanasiyana. Mu trimester yoyamba, imagwera, ndipo chachiwiri ndi chachitatu chikuwonjezeka, kotero kusintha kwa mankhwalawa kungakhale kofunikira.

Komanso, kusintha kwa muyezo, kudya ndi kuchita masewera olimbitsa thupi zingafunikire panthawi yochepa.

Ngati kukonzekera kwa insulin kumene kumakhala koyenera kwa wodwala matenda a shuga, ndiye kuti ndemanga za Humulin M3 nthawi zambiri zimakhala zabwino. Malinga ndi odwala, mankhwalawa ndi othandiza kwambiri ndipo mothandizidwa alibe zotsatira zoyipa.

Ndikofunika kukumbukira kuti ndizoletsedwa kupatsa insulin nokha, komanso kusintha kwina.

Botolo imodzi ya Humulin M3 yokhala ndi voliyumu ya 10 ml imayambira ku 500 mpaka 600 ma ruble, paketi la makatoni atatu a 3 ml okhala ndi ma ruble a 1000-1200.