Glibomet: ndemanga za anthu odwala matenda ashuga, mtengo ndi fanizo la mankhwala

Kumwa mankhwala a hypoglycemic nthawi zina ndikofunikira, makamaka pankhani ya odwala matenda ashuga omwe amafunikira mankhwala ena kuti azitha kupereka shuga m'magazi. Inde, pamsika wamakono wamankhwala pali mankhwala ambiri otere. Koma akatswiri nthawi zambiri amalimbikitsa mankhwalawa "Glibomet." Kuunikira kwa odwala matenda ashuga komanso madokotala akuwonetsa kuti mankhwalawa amakulolani kupirira mavuto.

Kufotokozera kwa kapangidwe kake. Fomu Yotulutsira Mankhwala

Mankhwala "Glibomet" amapezeka mu mawonekedwe a mapiritsi ozungulira oyera okhala ndi chipolopolo cholimba. Amayikidwa m'matumba oyenera a zidutswa 20. Mu pharmacy mutha kugula phukusi lokhala ndi matuza awiri.

Ichi ndi chida chophatikizidwa, motero, kapangidwe kake kamakhala ndi magawo awiri othandizira - glibenclamide (2,5 ml piritsi limodzi) ndi metformin mu mawonekedwe a hydrochloride. Inde, kukonzekera kumakhalanso ndi zinthu zothandiza, makamaka, wowuma wa chimanga, silicon dioxide, cellcrystalline cellulose, talc, diethyl phthalate, glycerin, cellulose acetate phthalate, gelatin.

Kodi mankhwalawa amakhudza bwanji thupi?

Inde, poyambira, ndikofunikira kumvetsetsa zomwe mankhwalawo ali. Zotsatira za hypoglycemic pokonzekera Glibomet zimatsimikiziridwa ndi zomwe zili ndi zigawo ziwiri nthawi imodzi.

Chida ichi chimagwira pa kapamba, monga pamasamba omwe amachititsa kuti insulini ipangidwe. Nthawi yomweyo, mankhwalawa amathandizira chidwi cha maselo olimbana ndi mahomoni awa. Chifukwa chake, Glibomet imathandizira kutsitsa shuga wamagazi popanda kugwiritsa ntchito insulin yopanga, yofunikira kwambiri kwa matenda ashuga a 2.

Mankhwala amakhalanso ndi milomo yotsitsa lipid. Mothandizidwa ndi iye, kuchuluka kwa mafuta m'magazi kumatsika, komwe kumachepetsa mwayi wamagazi m'magazi (ma magazi). Metformin ndi m'gulu la Biguanides. Izi zimayambitsa njira zamagwiritsidwe ntchito a glucose ndi minofu, zimalepheretsa gluconeogeneis mu chiwindi, ndipo zimalepheretsa adsorption yama chakudya ndi makhoma a m'mimba.

Glibenclamide imatengedwa mwachangu ndi makhoma a matumbo ndipo imakhala pafupi kwathunthu (97%) yomanga mapuloteni a plasma. Mu chiwindi, limasweka, ndikupanga metabolites osagwira, omwe amachotsedwa m'thupi limodzi ndi ndowe ndi mkodzo. Hafu ya moyo ndi maola 5. Metformin imadziwikanso mwachangu mthupi, koma sikugwirizana ndi mapuloteni a plasma. Izi sizimaphatikizidwa m'thupi. Hafu ya moyo ndi maola awiri.

Kodi mankhwalawo amagwiritsidwa ntchito bwanji?

Anthu ambiri ali ndi matenda onga matenda ashuga 2. Zakudya ndi chithandizo pankhaniyi ndizofunikira kwambiri. Monga lamulo, kwa odwala amapanga zakudya zoyenera. Mutha kusintha shuga yanu yamagazi ndi sulfonylureas.

Mankhwala "Glibomet" amawonetsedwa ngati chithandizo chamankhwala ndikudya ndalama zomwe zili pamwambazi sizimapereka mphamvu yofunikira.

Mlingo ndi malingaliro ogwiritsa ntchito

Momwe mungamwe mankhwalawa "Glibomet"? Mlingo umatsimikiziridwa payekhapayekha. Monga lamulo, mlingo woyambirira ndi mapiritsi awiri. Amatengedwa ndi chakudya. Komanso, kuchuluka kwa mankhwalawa kumawonjezereka kuti akwaniritse kwambiri. Mlingo wa tsiku ndi tsiku sayenera kupitirira 2 g ya metformin. Kenako, mlingo umachepetsedwa.

Mankhwala "Glibomet": contraindication pa mankhwala

Uwu ndi mankhwala amphamvu komanso amphamvu, kulandiridwa kwake komwe kumatheka kokha ndi chilolezo cha dokotala. Mankhwala ali ndi mndandanda wosangalatsa wa zotsutsana, zomwe muyenera kuzidziwa musanayambe chithandizo:

• Hypersensitivity magawo othandizira komanso othandiza pamapiritsi,
• Matupi a sulfonylurea zotumphukira zina, komanso sulfamide, probenecid kapena sulfamide diuretics,
• Mankhwala omwe amapezeka mwa amayi panthawi yoyembekezera,
• kuchepa kwa mphamvu kuchokera ku mankhwala,
• matenda ashuga komanso ovuta
• kukhumudwa kwa aimpso, kulephera kwa impso,
• kusowa kwamadzi
• matenda opatsirana
• matenda otupa omwe angayambitse kukula kwa minofu hypoxia,
• kwambiri pathologies a mtima dongosolo, kuphatikizapo mavuto kufalikira, kuchepa kwa mtima, kuchepa kwa matenda oopsa ndi mtima.
• matenda oopsa a kupuma kwamthupi,
• myocardial infaration kapena nthawi yokonzanso pambuyo pake,
• kugwiritsa ntchito munthawi yomweyo mankhwala okodzetsa ndi mankhwala a kuthamanga kwa magazi,
• acidosis kapena chiwopsezo cha chitukuko chake,
• kukhalapo kwa mbiri ya wodwalayo pamilandu ya lactic acidosis,
• matenda oopsa a chiwindi
• mavuto a kupuma,
• kukonzanso pambuyo pang'ono pang'ono kapamba,
• dystrophic pathologies,
• uchidakwa wambiri, mkhalidwe woledzera pachimake,
• magazi akutuluka
• zigawenga
• kuyamwa
• kusala kudya kapena kutsatira zakudya zokhwima.

Ngati muli ndi zilizonse zotsutsana pamwambapa, ndiye chifukwa chake muyenera kuuza a endocrinologist.

Kodi njira zochizira zoopsa zomwe zimabweretsa ndi ziti?

Kodi nthawi zonse kumakhala kotetezeka kumwa mapiritsi a Glibomet? Zotsatira zoyipa zakumbuyo zamankhwala ndizotheka. Milandu yakuchitika kwawo, komabe, sikujambulidwa nthawi zambiri, koma chithandizo chimakhudza magulu osiyanasiyana.

• Dongosolo la Lymphatic ndi magazi. Hemolytic anemia, leukopenia, thrombocytopenia, pancytopenia, erythrocytopenia.
• CNS. Nthawi ndi nthawi kupweteka kwa mutu, kusokonezeka kwa kamvekedwe ka malingaliro.
• Zowongolera masomphenya. Kusokonezeka kwa malo okhala, kuchepa kwa maonedwe acuity, komwe kumalumikizidwa ndi kusintha kwa shuga m'magazi.
• Kupenda. Kuwonjezeka kwambiri kwa thupi, hypoglycemia, lactic acidosis. Kuchiza kwa nthawi yayitali nthawi zina kumabweretsa kuyamwa kwa vitamini B12 m'matumbo, omwe pambuyo pake amathandizira kukulitsa kuchepa kwa magazi m'thupi.
• Matumbo oyenda. Kusanza, kusanza, kutulutsa, kupweteka m'zigawo za epigastric, kugona pafupipafupi, kusowa chilakolako chakufa, mawonekedwe akumaso amkamwa, kumverera kwadzadza m'mimba.
• Khungu komanso minyewa yofinya. Khungu loyenda, erythema, mitundu yosiyanasiyana ya exanthema, limakulitsa khungu lathu kuti lisinthe, khungu lawo siligwirizana.
• Thupi lawo siligwirizana. Kuwala pakhungu, kutupa, jaundice, kuchepa kwakukulu kwa kuthamanga kwa magazi, kupuma, zochitika zadzidzidzi.
• Chiwindi. Intrahepatic cholestasis, mankhwala a chiwindi.
• Mavuto ena amatha kuwonekera, makamaka, kuchuluka kwamkodzo tsiku lililonse, kuwonongeka kwa mapuloteni ndi sodium ndi thupi chifukwa cha kusokonezeka kwa impso.

Ndikofunika kudziwa kuti ambiri mwamavutikawa safuna kuti athetse chithandizo chokwanira - ndikokwanira kuti muchepetse mulingo wake ndipo zotsatirapo zake zimasiyana lokha. Kuchuluka kwa tsiku lililonse kwa mankhwalawa kuyenera kuwonjezeka pang'onopang'ono komanso pang'onopang'ono.

Zambiri pazokhudzana ndi mankhwala ena

Mankhwala "Glibomet" (metformin) sangatengedwe ndi ethyl mowa, chifukwa izi zimawonjezera mwayi wokhala ndi lactic acidosis. Pa chithandizo, zakumwa zoledzeretsa komanso zakumwa zoledzeretsa ziyenera kutayidwa.

Kugwiritsa ntchito mankhwalawa kumayimitsidwa maola 48 njira zisanagwiritsidwe ntchito poyerekeza ndi ayodini. Kugwiritsa ntchito munthawi yomweyo mankhwalawa kungayambitse kulephera kwa impso.

Ngati mutenga "Glibomet" limodzi ndi insulin, anabolic steroids, beta-adrenergic blockers, mankhwala a tetracycline, ndiye kuti chiopsezo chokhala ndi hypoglycemia chikuwonjezeka. Anthu odwala matenda ashuga nthawi zonse amafunika kudziwitsa dokotala za mankhwala omwe amamwa.

Mtengo ndi fanizo

Mankhwala amakono, mankhwala "Glibomet" amagwiritsidwa ntchito nthawi zambiri. Ndemanga ya anthu odwala matenda ashuga, zikuwonetsa ndi zotsutsana ndi, zinthu zofunika. Koma chosasiyananso ndi mtengo wake. Zachidziwikire, ndizovuta kutchula nambala yeniyeni, koma mwatsatanetsatane mtengo wa mapiritsi 40 umachokera ku 340 mpaka 380 rubles, womwe kwenikweni siwambiri.

Inde, mankhwalawa sakhala oyenera nthawi zonse kwa odwala. Pali zolowa m'malo zokwanira pamsika wamakono wamankhwala. Mwachitsanzo, ndi matenda ashuga amtundu wachiwiri, njira monga Avandamet, Vokanamet, Glukovans amagwiritsidwa ntchito nthawi zambiri. Osatinso kawirikawiri, odwala amapatsidwa Dibizid, Dianorm kapena Sinjarji. Zachidziwikire, ndiopezeka pa endocrinologist okha omwe angasankhe analogue yothandiza.

Mankhwala "Glibomet": ndemanga za odwala matenda ashuga ndi madokotala

Mankhwalawa amagwiritsidwa ntchito kwambiri ngati mankhwala amakono. Koma kodi chithandizo ndi Glibomet chimawoneka bwanji? Ndemanga ya anthu odwala matenda ashuga, komanso akatswiri, amatsimikizira kuti mankhwalawa amathana bwino ndi zotsatira za matenda osokoneza bongo omwe amadalira shuga.

Malinga ndi kafukufuku, mankhwalawa amayambitsa gawo la kapamba yemwe amayambitsa kuphatikizira kwa insulin. Izi ndizomwe zimafunikira kwa matenda monga matenda a shuga 2. Zakudya ndi chithandizo pankhaniyi ndizofunikira kwambiri.

Mavuto azotsatira zamankhwala samachitika kawirikawiri. Mankhwalawa amalekeredwa bwino, ndipo mtengo wake ndi wovomerezeka.

Zotsatira za mankhwalawa pa thupi

Kafukufuku wambiri wochitidwa ndi akatswiri padziko lonse lapansi atsimikizira kuti mankhwalawa, omwe ali ndi INN yotchedwa Metformin, amayamba maola awiri atagwiritsidwa ntchito, ndipo amatha pambuyo maola 12. Ndikokwanira kuti wodwalayo atenge kawiri pa tsiku kuti akhale ndi moyo wabwino komanso wathanzi. Wodwala ayenera kumvetsetsa kuchuluka kwa mankhwalawa omwe amayenera kumwa ndi mitundu yosiyanasiyana ya shuga.

Odwala ena amadandaula chifukwa cha kugwiritsidwa ntchito kwa mankhwalawa, zimachitika mwa wodwala pamaso pa tsankho la munthu pazigawo za mankhwala. Ndikofunika kusanthula pasadakhale kuyanjana kwa thupi la munthu ndi zigawo za mankhwalawo ndikuyamba kulandira chithandizo.

Mutatha kumwa mapiritsi, thupi limayamba kupanga insulin mwachangu. Mukamwa mankhwalawa, maulendo angapo amapangidwa kuposa momwe amayamba mankhwala. Katundu woyambira wogwira amakhala ndi mphamvu pancreatic mthupi la munthu, koma biguanide yomwe ilipo mu mankhwalawa imakhala ndi mphamvu yowonjezera - kupangika kwa glucose komwe thupi la wodwala limayamba.

Odwala ena amakhulupirira kuti kuchira koyenera ndikokwanira kumwa mankhwala ena ndipo thanzi lidzasintha. Sikokwanira kupita kwa adotolo ndikumuwuza china chake ngati mutha kuthana ndi matenda a shuga kapena mundiuze, chonde, piritsi logwiritsira ntchito kwambiri, mwachitsanzo, mowa. Pochotsa matenda, ndikofunikira kutsatira zakudya zoyenera ndikulimbitsa thupi mokwanira ndi zochitika zolimbitsa thupi. Osachulukitsa thupi siziyenera.

Ngati wodwalayo aphatikiza kugwiritsa ntchito bwino mankhwala, kudya moyenera komanso kuchita masewera olimbitsa thupi, akhoza kukwanitsa zotsatirapo zake.

Contraindication pakugwiritsa ntchito mankhwala

Ndikofunikira kudalira dokotala wanu osati malingaliro a odwala ena.

Kuphatikizidwa kwa glibenclamide ndi metformin kumathandiza kuti shuga ya thupi ikhale yovomerezeka kwa anthu.

Monga mankhwala ena aliwonse, glibomet yokhala ndi glibenclamide ndi metformin imakhala ndi zotsutsana.

Mfundo zazikuluzikulu zogwiritsa ntchito mankhwalawa ndi izi:

• mtundu 1 shuga
• lactic acidosis nthawi,
• wodwala matenda ashuga kapena wofanana
• matenda ophatikizidwa ndi chimbudzi cham'mimba,
• matenda ovuta omwe angayambitse kulephera kwa impso,
• chiwindi ntchito mavuto ndi zina zambiri.

Thupi la odwala matenda ashuga amadwala matenda ena akuluakulu komanso matenda am'magazi oyenda mkati mwa ziwalo zamkati, kukulira motsutsana ndi matenda omwe amayambitsidwa. Chifukwa chake, musanayambe chithandizo cha matenda omwe ali ndi vuto lililonse ndi mankhwala aliwonse, ndikofunikira kupenda thupi kuti muwone ngati wodwalayo angakhale ndi zotsatirapo zoyipa komanso zotsatirapo zoipa chifukwa chomwa mankhwalawo.

Ndikofunikira kuti mumvetsetse bwino kuchuluka kwa mankhwalawa omwe ali oyenera kwa wodwala winawake, ndizotheka kusankha mawonekedwe a mankhwalawa. Ponena za analogue, chisamaliro chiyenera kutengedwa kuti musankhe choyenera kwambiri. Madokotala ambiri amalimbikitsa odwala kuti asinthe mankhwalawo ngati zotsatira zoyipa ziyamba kuonekera. Glucophage ndi yotchuka ngati analogue, yomwe imakhudzanso thupi la wodwalayo.

Kusankha mankhwala othandiza kwambiri, ndikofunikira, posankha mankhwala, kuti muphunzire mwatsatanetsatane malangizo ogwiritsira ntchito mankhwalawa komanso kuwunika kwa wodwalayo za iwo. Kuwerenga malangizo ogwiritsira ntchito mankhwalawa Glibomet ndi kuwunika kwa wodwalayo kumatithandiza kumvetsetsa zonse zomwe tikugwiritsa ntchito pogwiritsira ntchito mankhwalawa ndikupanga kugwiritsa ntchito kosavulaza komanso kogwira mtima momwe kungathekere.

Musanagule mankhwala, Glybomet ndikofunikira kudziwa bwino momwe mungagwiritsire ntchito, chidziwitso chotere chimapezeka pa intaneti, ngati mukufuna, aliyense angadziwe nthawi iliyonse.

Kuwonetsedwa kwa zoyipa

Chipangizocho chili ndi zoletsa zaka. Odwala ochepera zaka khumi ndi zisanu ndi zitatu samalimbikitsa kuti azigwiritsidwa ntchito.

Mankhwalawa atha kugulidwa ku pharmacy iliyonse ku Russia. Muyenera kuchita izi mukakambirana ndi dokotala komanso kulandira mankhwala kuchokera kwa iye. Zomwezi zimagwiranso ntchito nthawi yomwe wodwala aganiza kuti asinthe mankhwalawo ndi analogue.

M'malo mwake mankhwalawo atha kuchitika pambuyo poti aunikiridwa ndi adokotala komanso pakulimbikitsa. Chenjezo limayenderana ndi chakuti chophatikiza chachikulu chimagwira ndi metformin, yomwe imakhala, ngati mankhwala osokoneza bongo, omwe amayambitsa kukula kwa matenda a shuga a wodwala. Glybomet sioyenera kuyamba mankhwalawo.

Kutengera ndi chidziwitso chonse chomwe tafotokozazi, kumwa mankhwala a Glibomet pamapiritsi kumatha kutsagana ndi zovuta monga:

1. Wamphamvu mutu nabol.
2. Matenda a shuga
3. Mavuto a magazi (kuundana kwa magazi, ndi zina).
4. Kuwonongeka kwa chapakati mantha dongosolo.
5. Momwe thupi limasokoneza pakhungu ndi zina zambiri.

Chifukwa chake, pakuzindikira koyambirira kwa zizindikiro zotere mutatha kumwa Glibomet, muyenera kufunsa dokotala ndipo ngati kuli koyenera, funani yomweyo m'malo mwake mankhwalawo, apo ayi mutha kuwononga thanzi lanu koposa.

Malangizo ogwiritsira ntchito mankhwalawa

Palibenso chocheperako kwenikweni funso la momwe mungagwiritsire ntchito chida chomwe chatchulidwachi. Zambiri pazomwe mungatenge Glibomet molondola zitha kuperekedwa ndi dokotala. Ndi iye yekha, atayang'anitsitsa wodwala wake, angathe kupatsa lingaliro lamankhwala lomwe limafotokoza kuchuluka kwa mankhwalawa ndikuyenera kukhala ndi dongosolo laudindo.

Kumayambiriro kwa mankhwalawa, mlingo wocheperako umaperekedwa, umachokera ku mapiritsi atatu mpaka atatu. Kenako, ngati pakufunika kutero, muyezo utha kuchuluka. Chiwerengero chachikulu cha mapiritsi omwe wodwala mmodzi amatha kumwa masana sayenera kupitirira zidutswa zisanu ndi chimodzi.

Izi zikufotokozedwa mwatsatanetsatane ndi zonunkhira za mankhwalawa, zomwe zimagwirizidwa phukusi lililonse la mankhwalawo. Koma ilibe kuchuluka koyenera, komanso kapangidwe kake ka mankhwala. Chifukwa chake, ngati wodwala samvera chilichonse, akhoza kumdziwitsani adokotala pasadakhale izi, atawerenga kale malangizowo.

Ponena za mtengo wa mankhwalawa, amatha kusiyanasiyana pang'ono kutengera kuchuluka kwa zomwe zimagwiritsidwa ntchito ndi mankhwala. Pafupifupi, mtengo wake umachokera ku ma ruble mazana awiri mpaka atatu.

Glibomet 2.5 ndi yotsika mtengo pang'ono kuposa malonda omwewo, omwe amaphatikizapo 5 mg pazinthu zazikulu, zomwe ndi Glibomet 5 +400.

Kodi ndikofunika kukumbukira chiyani mukamagwiritsa ntchito Glibomet?

Musanayambe kugwiritsa ntchito mankhwala Glibomet, malangizowo ayenera kuphunziridwa mwatsatanetsatane, muyenera kuwerengera chithunzi cha mankhwalawo kuti mumvetsetse bwino ngati mankhwalawo agulidwa.

Monga tafotokozera pamwambapa, pali mafanizo ambiri omwe madokotala angalimbikitse. Pakati pawo, mankhwala akuluakulu ndi Glucofage 850. Odwala ambiri amayesa kudziwa kuti ndibwino liti pazithandizo ziwiri izi. Zimakhala zovuta kupereka yankho lenileni. Zonse zimatengera mawonekedwe amunthu wodwala komanso kuopsa kwa matendawo.

Kupezeka kwa matenda opatsirana kumathandizanso kwambiri. Ngati pali zovuta ndi chiwindi, muyenera kusamala mukamapereka mankhwala. Ndikwabwino pankhaniyi nthawi zonse kumwa mankhwala ofanana omwe amathandizira ntchito ya chiwindi palokha, mwachitsanzo, Essentiale forte. Komanso, kuyanjana kwa mankhwalawa ndi hypoglycemic ndizabwino. Upangiri womwewo womwe ungaperekedwe pankhani ya mankhwala, omwe akuwonetsa kuti muyenera kutenga glucophage.

Zakhala zikunenedwa pamwambapa kuti Glibomet yayitali sikulimbikitsidwa kuti igwiritsidwe ntchito ndi odwala omwe ali ndi zaka 18. Chifukwa chake, ngati pakufunika kusankha mankhwala kwa mwana, izi zimayenera kuganiziridwa.

Pali zithandizo zambiri zomwe Maninil alipo. Chifukwa chake, nthawi zonse mungasankhe njira yoyenera kwambiri yodwala.

Odwala ena amaganiza kuti Glucophage ndi Glybomet ndi ma syonyms. Koma awa ndi malingaliro olakwika, awa ndi mitundu iwiri yosiyanasiyana ya mankhwala, ngakhale pali kufanana zambiri pakati pawo. Komanso, zonse zikuchokera komanso mogwirizana ndi momwe thupi limakhudzira.

Muyenera kusankha mlingo wa mankhwalawa mosamala kutengera mtundu wa mankhwalawa. Kupatula apo, pali mapiritsi omwe ali ndi 2,5 mg pazomwe zimagwira, ndipo pali zomwe zimaphatikizapo 5 mg ya chinthu chomwecho.

Ndi mankhwala ati a shuga omwe ali othandiza kwambiri akufotokozedwa mu kanema munkhaniyi.

Zotheka m'malo mwa Glibomet

Bagomet Plus (mapiritsi) Kutalika: 37

Analogue ndiotsika mtengo kuchokera ku ma ruble 78.

Wopanga: Kimika Montpelfer (Argentina)
Kutulutsa Mafomu:

• Tab. 2,5 mg + 500 mg, 30 ma PC.
• Tab. 5 mg + 500 mg, 30 ma PC.

Malangizo ogwiritsira ntchito

Wopindulitsa kwambiri waku Argentina Glibomet wogwirizira ndi zida zomwezo, koma muyezo wosiyanako. Mosiyana ndi "choyambirira" phukusi lomwe lili ndi mapiritsi 10 ochepa, kotero ndi chithandizo chazitali, phindu limakhalanso locheperako.

Metglib (mapiritsi) Kutalika: 47

Analogue ndiotsika mtengo kuchokera ku ma ruble 72.

Ma analogue osankhidwa a zinthu zogwiritsidwa ntchito ndi mlingo wake pa piritsi 1 siyosiyana ndi Glibomet. Amagulitsidwa mwanjira yomweyo kuti amasulidwe ndipo cholinga chake ndi kuchiza matenda a shuga a mtundu wachiwiri. Pali contraindication ndi mavuto.

Analogue ndiotsika mtengo kuchokera ku ma ruble 46.

Ma Glucovans pamtengo wokutengera amafanana ndi mankhwala "apachibale", koma ali ndi mapiritsi 10 ochepa. Zizindikiro zogwiritsidwa ntchito ndizofanana. Glucovans amagwiritsidwa ntchito mtundu 2 shuga mellitus ndi kusakwanira zakudya komanso zolimbitsa thupi.

Analogs Glibomet

Machesi molingana ndi mawonekedwe

Mtengo kuchokera ku ma ruble 90. Analogue ndiotsika mtengo ndi 197 rubles

Machesi molingana ndi mawonekedwe

Mtengo kuchokera ku ma ruble 97. Analogue ndiotsika mtengo ndi ma ruble a 190

Machesi molingana ndi mawonekedwe

Mtengo kuchokera ku ma ruble 115. Analogue ndiyotsika mtengo ndi ma ruble 172

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 130. Analogue ndiyotsika mtengo ndi ma ruble 157

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 273. Analogue ndiotsika mtengo ndi ma ruble 14

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 288. Analogue ndiokwera mtengo kwambiri ndi ma ruble 1

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 435. Analogue ndiokwera mtengo kwambiri ndi ma ruble 148

Machesi molingana ndi mawonekedwe

Mtengo wake umachokera ku ma ruble 499. Analogue ndiokwera mtengo kwambiri ndi ma ruble 212

Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Machesi molingana ndi mawonekedwe

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Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mapiritsi okhala ndi mbali yoyera, yozungulira, ya biconvex, yokhala ndi chiopsezo mbali imodzi, yopanda fungo.

1 tabu
glibenclamide	2,5 mg
metformin hydrochloride	400 mg

Omwe amathandizira: cellcrystalline cellulose - 65 mg, wowuma chimanga - 57,5 ​​mg, colloidal silicon dioxide - 20 mg, gelatin - 40 mg, glycerol - 17,5 mg, talc - 15 mg, magnesium stearate - 7.5 mg.

Ma Shell: mapiritsi a acetylphthalyl - 2 mg, diethyl phthalate - 0,5 mg, talc - 2.5 mg.

20 ma PC. - matuza (2) - mapaketi a makatoni.
20 ma PC. - matuza (3) - mapaketi a makatoni.
20 ma PC. - matuza (5) - mapaketi a makatoni.

Zotsatira za pharmacological

Kukonzekera kwa pakamwa kwa hypoglycemic komwe kumachitika kumakhala ndi sulfonylurea yochokera m'badwo wachiwiri ndi biguanide. Ili ndi pancreatic ndi extrapancreatic zotsatira.

Glibenclamide - wotchedwa sulfonylurea wochokera m'badwo wachiwiri. Imalimbikitsa kukonzekera kwa insulini pochepetsa kutsekemera kwa kupukusira kwa shuga (glucose), kumakulitsa chidwi cha insulin komanso kumangiriza ma cell omwe mukufuna, kumawonjezera kutulutsidwa kwa insulini, ndikuwonjezera zochita za insulin pa minofu ndi chiwindi cha glucose, ndikuletsa lipolysis mu minofu ya adipose. Machitidwe mu gawo lachiwiri la insulin.

Metformin A gulu la Biguanides. Zimapangitsa chidwi cha zotumphukira zama minofu ndikuchita insulin (kumawonjezera insulin yomanga ma receptor, kumathandizira zotsatira za insulin pamlingo wa postreceptor), kumachepetsa mayamwidwe am'matumbo, kupondereza gluconeogenesis ndipo imathandizira pakupezeka kwa metabolidi a lipid, kumathandizira kuchepetsa kuchuluka kwa thupi kwa odwala omwe ali ndi matenda a shuga. imakhalanso ndi vuto la fibrinolytic mwa kuponderezana ndi minofu ya mtundu wa plasminogen activator inhibitor.

Hypoglycemic zotsatira za mankhwalawa zimayamba pambuyo pa maola awiri ndipo zimatha maola 12.

Kuphatikizika kwa mitundu iwiri yogwira pophika mankhwala - mphamvu yolimbikitsira ya sulfonylurea yokhudzana ndi kupanga kwa amkati a insulin (pancreatic athari) ndi chiwonetsero chokwanira cha gluuanide pa minofu ndi mafuta minyewa (kuchuluka kwakukulu kwa glucose - kuphatikiza kwa gluconeic) ndi kuchepa kwa shuga. Mlingo umachepetsa zomwe zili m'chigawo chilichonse. Izi zimathandiza kupewa kukondoweza kwambiri kwa β-cell a kapamba, chifukwa chake, amachepetsa chiwopsezo cha ntchito, komanso bwino chitetezo cha mankhwala a hypoglycemic ndikuchepetsa pafupipafupi mavuto.

Pharmacokinetics

Zogulitsa ndi kugawa

Mwansanga komanso mwachilungamo kwathunthu (84%) amatengedwa kuchokera m'matumbo am'mimba, nthawi yofika C_max ndi maola 1-2. Kumangiriza mapuloteni a plasma - 97%.

Kutetemera ndi chimbudzi

Imakhala ngati imapukusidwa kwathunthu m'chiwindi kuti metabolites osagwira. Imafufutidwa ndi impso (50%) komanso ndi bile (50%). T_1/2 kuyambira maola 5 mpaka 10

Zogulitsa ndi kugawa

Imapinda bwino m'mimba, imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma.

Kutetemera ndi chimbudzi

Sipakonzedwa m'thupi, limasinthidwa osasinthidwa makamaka ndi impso ndipo, gawo lina, kudzera m'matumbo. T_1/2pafupifupi maola 7

- lembani matenda ashuga a 2 a shuga ndi kusachita bwino kwa mankhwala akudya ndi chithandizo cham'mbuyomu ndi sulfonylureas kapena biguanides, komanso othandizira ena pakamwa.

Mlingo

Mankhwala amatengedwa pakamwa ndi chakudya.

Mlingo ndi kutalika kwa mankhwala zimatsimikiziridwa ndi kupezeka dokotala kutengera mphamvu ya kagayidwe kazakudya komanso kuchuluka kwa shuga m'magazi.

Poyambirira mlingo zambiri 1-3 mapiritsi / tsiku ndi zina pang'onopang'ono kusankha yogwira mlingo mpaka olimba masanjidwe a kuchuluka kwa shuga m'magazi zimatheka.

Pazipita tsiku lililonse mankhwala a Glibomet ® ndi mapiritsi 6.

Malangizo apadera

Mankhwalawa, odwala ayenera kutsatira malangizo a dokotala pokhudzana ndi kuchuluka ndi momwe angagwiritsire ntchito mankhwalawo, komanso kutsatira zakudya, kuchita masewera olimbitsa thupi komanso kudziyang'anira pawokha kuchuluka kwa shuga.

Lactic acidosis ndi njira yachilendo komanso yowopsa ya moyo yodziwika ndi kuphatikizika kwa lactic acid m'magazi, omwe mwina amayamba chifukwa cha kuchuluka kwa metformin. Zofotokozedwa za chitukuko cha lactic acidosis mwa odwala omwe amalandira metformin amawonekera kwambiri mwa odwala omwe ali ndi matenda osokoneza bongo omwe ali ndi vuto lalikulu la mtima komanso aimpso. Kupewera kwa lactic acidosis kumaphatikizapo kuzindikiritsa zinthu zonse zokhudzana ndi chiopsezo, monga matenda osakhazikika a shuga, ketosis, kusala kudya kwa nthawi yayitali, kumwa kwambiri mowa, kulephera kwa chiwindi ndi vuto lililonse lomwe lingakhale ndi hypoxia.

Mukamatenga Glibomet ®, kuchuluka kwa serum creatinine kuyenera kuyang'aniridwa pafupipafupi:

- osachepera kamodzi pachaka kwa odwala omwe ali ndi vuto laimpso,

- osachepera 2-4 pachaka odwala omwe amapezeka ndi serum creatinine pafupi ndi VGN, komanso odwala okalamba.

Chenjezo liyenera kuchitika pokhapokha ngati pali vuto laimpso, mwachitsanzo, popereka mankhwala a antihypertensive kapena okodzetsa, kumayambiriro kwa mankhwala a NSAID. Kuchiza ndi Glibomet ® kuyenera kusiyidwa kwa maola 48 isanachitike ndi X-ray yokhala ndi iv. Yothandizirana ndi iodine m'malo mwake ndi mankhwala ena a hypoglycemic (mwachitsanzo, insulin).

Kugwiritsa ntchito mankhwalawa Glibomet ® kuyenera kuyimitsidwa maola 48 isanachitike opaleshoni yomwe idakonzedwa pansi pa opaleshoni ya msana kapena ya cell. Mankhwalawa amayenera kupitilizidwa pambuyo poti ayambanso kudya pakamwa kapena osachepera maola 48 atachitidwa opaleshoni, ngati chithandizo chokwanira cha impso chikutsimikiziridwa.

Ethanol imatha kuyambitsa chitukuko cha hypoglycemia, komanso kugwiranso ntchito kwa disulfiram (nseru, kusanza, kupweteka kwam'mimba, kumva kutentha pakhungu la nkhope ndi thupi lakumtunda, tachycardia, chizungulire, kupweteka mutu, chifukwa chake muyenera kupewa kumwa mukamalandira chithandizo ndi Glibomet ®.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Mukamamwa mankhwalawa Glybomet ®, hypoglycemia ikhoza kukhala, ndipo chifukwa chake, kutsika kwa chidwi chokwanira komanso kuthamanga kwa zochitika zama psychomotor, chifukwa chake, pakumwa mankhwala, kusamala kuyenera kugwiritsidwa ntchito poyendetsa magalimoto, machitidwe ndi kuchita zochitika zoopsa.

Bongo

Zizindikiro lactic acidosis (chifukwa cha metformin), hypoglycemia (chifukwa cha glibenclamide).

Zizindikiro za lactic acidosis: kufooka kwambiri, kupweteka kwa minofu, kupuma, kugona, nseru, kuchepa kwa magazi, Reflex bradyarrhythmia, chisokonezo komanso kusazindikira.

Zizindikiro za hypoglycemia: Njala, thukuta kwambiri, kufooka, palpitations, khungu pakhungu, paresthesia mkamwa, kunjenjemera, nkhawa zambiri, kupweteka kwa mutu, kugona tulo, vuto la kugona, kumva mantha, kulumikizana kwakanthawi, kusokonezeka kwa minyewa kwakanthawi. Ndi kupita patsogolo kwa hypoglycemia, kulephera kudziletsa komanso kuzindikira kuli kotheka.

Chithandizo: ngati lactic acidosis ikukayikiridwa, kuchoka kwa mankhwala ndi kuchipatala kwadzidzidzi ndikulimbikitsidwa. Chithandizo chothandiza kwambiri ndi hemodialysis.

Ndi hypoglycemia wofatsa, muyenera kumwa chidutswa cha shuga, chakudya kapena zakumwa zambiri zamafuta (kupanikizana, uchi, kapu ya tiyi wokoma) mkati.

Pofuna kutaya chikumbumtima, ndikofunikira jakisoni 40-80 ml iv wa 40% dextrose solution (glucose), kenako ndikuwapatsa 5-10% dextrose solution. Kenako mutha kuwonjezera 1 mg wa glucagon mu / mu, / m kapena s / c. Ngati wodwalayo sakudziwikanso, ndikofunikira kuti njira izi zibwerezedwe. Popanda kuchitapo kanthu, chisamaliro chachikulu chimawonetsedwa.

Kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya hypoglycemic ya mankhwala Glybomet ® imakonzedwa ndikuwongolera nthawi imodzi ya coumarin derivatives (warfarin, syncumar), beta-blockers, cimetidine, oxytetracycline, allopurinol, MAO inhibitors, sulfonamides, phenylbutazone, amampeneide amorteneide amorteneide. , miconazole (pakamwa pakamwa), sulfinpyrazone ndi ethanol.

Adrenaline, corticosteroids, kulera kwapakamwa, kukonzekera kwa mahomoni a chithokomiro, thiazide okodzetsa ndi barbiturates amachepetsa mphamvu ya hypoglycemic ya mankhwala a Glybomet ®.

Pogwiritsa ntchito munthawi yomweyo ndi mankhwala a Glybomet ®, machitidwe a anticoagulants akhoza kupitilizidwa.

Kugwiritsa ntchito limodzi ndi cimetidine kungakulitse chiopsezo cha lactic acidosis.

Kugwiritsa ntchito ma beta-blockers kumatha kuphimba zizindikiro za hypoglycemia (kupatula kutuluka thukuta kwambiri).

Kugwiritsidwa ntchito kwa mankhwala okhala ndi ayodini omwe ali ndi ayodini (chifukwa cha kayendedwe ka mafupa) kungayambitse matenda aimpso ndi kuwonongeka kwa metformin, yomwe imawonjezera chiopsezo cha lactic acidosis.

Zizindikiro zogwiritsa ntchito Glibomet

Chimodzi mwazochita za mankhwalawa ndikulimbikitsa kupanga kwake insulin. Izi ndizotheka pokhapokha ngati wodwala ali ndi maselo a beta mu kapamba, chifukwa chake mapiritsi a Glibomet ndi omwe amapatsidwa kokha ndi mtundu 2 wa shuga. Ndi matenda amtundu 1, mankhwalawa ndi osathandiza.

Zisonyezo zogwiritsidwa ntchito:

1. Odwala omwe amawonetsedwa chithandizo ndi zovuta ziwiri (ndi glycated hemoglobin yopitilira 8%) kapena atatu (HH> 9%) othandizira a hypoglycemic.
2. Odwala omwe ali ndi zakudya, masewera, komanso metformin kapena glibenclamide omwe adatchulidwa kale samapereka kuchepetsedwa kwa shuga.
3. Anthu odwala matenda ashuga osalolera omwe amakhala ndi miyeso yambiri ya metformin.
4. Kusintha mankhwala awiri ndi mmodzi mwa odwala omwe ali ndi shuga yayitali.

Mapiritsi onse a sulfonylurea antidiabetesic angayambitse hypoglycemia. Glibomet sichoncho. Glibenclamide, yomwe ndi gawo lake, ndi mankhwala amphamvu kwambiri m'gululi, zomwe zikutanthauza kuti lilinso loopsa kwambiri pankhani ya hypoglycemia.

Odwala omwe ali ndi lingaliro lakuchepa kwambiri kwa shuga kapena ndi zizindikiro zochepa za Glybomet amayesetsa kuti asalembe. Atsopano a matenda ashuga ndi oyenera kwambiri kwa odwala matenda ashuga awa.

The zikuchokera ndi tanthauzo la mankhwala

Zotsatira zamankhwala zimachitika chifukwa cha zinthu zomwe zimapanga zomwe zimapangidwa. Piritsi limodzi la Glibomet lili ndi 400 mg ya metformin, 2.5 mg ya glibenclamide.

Metformin imagwira ntchito popanga kagayidwe kachakudya pogwiritsa ntchito njira zingapo. Palibe wa iwo omwe amakhudza mwachindunji kapamba. Metformin imachepetsa kutulutsa shuga m'magazi ndi chiwindi, zomwe zimathandizira kukula kwa shuga. Imawonjezera kuyankha kwa maselo ku insulin, yomwe imapangitsa kuti shuga imagwiritsidwe ntchito ndi minyewa yokhala ndi insulin - minofu, mafuta, komanso chiwindi. Popeza metformin sikukhudza maselo a beta, singayambitse hypoglycemia.

Mwa zina zowonjezereka za chinthu ichi, chofunikira kwambiri mu matenda osokoneza bongo ndi zotsatira za metformin pakutha kwa magazi kusungunuka kwamagazi omwe ayamba kumene kupanga. Awa ndi mankhwala okhawo omwe ali ndi vuto la antiidiabetes omwe adatsimikiziridwa kuti achepetse chiopsezo cha zovuta zazikulu za matenda ashuga. Metformin imachepetsa kufa ndi 42%, kugunda kwa mtima ndi 39%.

Ntchito yachigawo chachiwiri cha Glibomet, glibenclamide, ndikupititsa patsogolo katulutsidwe ka insulin yake. Kuti muchite izi, zimagwirizanitsa ndi beta-cell receptors ndipo, monga glucose, imalimbikitsa ntchito yawo. Mu gulu lake, glibenclamide ndi mankhwala amphamvu kwambiri pazotsatira za hypoglycemic. Amathandizanso kuwonjezera masitolo a glycogen mu minofu minofu. Malinga ndi madokotala, kutenga glibenclamide mwa odwala omwe ali osakwanira kapangidwe ka insulin kumatha kusintha njira ya shuga ndikuchepetsa kuchuluka kwa zovuta za 25vas.

Chifukwa chake, mankhwalawa Glybomet amakhudza zomwe zimayambitsa hyperglycemia: imabwezeretsa insulin yopanga komanso imachepetsa kukana insulin.

Ubwino wa Glibomet:

• kugwiritsa ntchito mosavuta. M'malo mwa mapiritsi 6, atatu akukwana,
• kuchepetsa shuga musanadye komanso chakudya,
• kuthekera kuchepetsa kuchuluka kwa mapiritsi 1-2 ngati kubwezeretsedwa kwa matenda a shuga.
• kuchitapo kanthu - kukonza lipid mawonekedwe amwazi, kuchepetsa kuchepa kwa magazi, kutsitsa magazi,
• inachepetsa njala. Malinga ndi odwala matenda ashuga, izi zimakupatsani mwayi wophatikiza zakudya,
• kupezeka - Glybomet itha kugulidwa pafupifupi mankhwala onse pamtengo wotsika mtengo. Kuchiza ndi mankhwala awiri omwe ali ndi mawonekedwe omwewo, mwachitsanzo Maninil ndi Siofor, adzagula ndalama zambiri kuposa kumwa Glibomet wophatikizidwa.

Momwe angatenge

Kuchepetsa shuga mutamwa Glibomet kumayamba mu 2 hours ndipo kumatenga maola 12, chifukwa chake malangizo omwe angagwiritsidwe ntchito amalimbikitsa kumwa mankhwalawa kawiri pa tsiku. Imwani piritsi ndi chakudya.

Mlingo wa mankhwalawa umatsimikiziridwa ndi endocrinologist. Pankhaniyi, kuchuluka kwa shuga, zaka, kulemera kwa wodwalayo, chakudya chake, chizolowezi cha hypoglycemia ziyenera kukumbukiridwa.

Momwe mungasankhire mlingo woyenera:

1. Kuyamba kwa mapiritsi 1-3. Mokulira glycemia, mapiritsi ambiri amafunikira. Ngati wodwala sanamwe mankhwala omwe ali ndi zomwezi, ndi bwino kuyamba ndi piritsi limodzi. Anthu odwala matenda ashuga omwe sanamwe kale metformin amwanso piritsi 1 limodzi masabata awiri oyamba. Izi nthawi zambiri zimayambitsa kusakhutira m'mimba. Kuzolowera, thupi limatenga nthawi pang'ono.
2. Kuchulukitsa muyezo ndi chiphuphu chosakwanira cha shuga kungakhale masiku atatu aliwonse. Ndi kulekerera bwino kwa metformin - milungu iwiri iliyonse.
3. Pazipita tsiku lililonse malingana ndi malangizo ndi mapiritsi 5. Kupitilira muyeso kumatha kuyambitsa matenda osokoneza bongo komanso hypoglycemia. Ngati mapiritsi 5 akukwana kulipirira shuga, mankhwalawa amathandizidwa ndi mankhwala ochokera m'magulu ena.

Mlingo wa metformin ku Glibomet ndi wocheperako. Pa mulingo wambiri watsiku ndi tsiku wa mapiritsi 4, odwala matenda ashuga amalandira 1600 mg ya metformin, pomwe mlingo wake wabwino ndi 2000 ndipo upamwamba ndi 3000 mg. Ngati wodwala yemwe ali ndi matenda am'mimba amadziwika ndi kunenepa kwambiri pamimba, kuthekera kapena kulekerera kwakanthawi kochita masewera olimbitsa thupi, kukana insulini yayikulu, shuga wamagazi, amalimbikitsidwa kuti atenge mankhwala owonjezera a metformin asanagone.

Zotsatira zoyipa ndi bongo

Zina mwazotsatira zoyipa za mankhwala Glibomet, zomwe zimadziwika kwambiri ndi hypoglycemia, yomwe imatha kukulitsidwa mpaka kukomoka kwa hypoglycemic. Gawo lalikulu la hypoglycemia ndi mapapu, omwe amafunikira kulowererapo kochepa kwa wodwala matenda a shuga. Choyambitsa kutsika kwa shuga chimatha kukhala chowonjezera cha Glibomet mlingo, kuphwanya zakudya, kuchita masewera olimbitsa thupi mopitirira muyeso kapena osakonzekera.

Mankhwala osokoneza bongo amachititsa kuti matenda ashuga achulukane - lactic acidosis. Nthawi zambiri, zinthu zokhudzana zimafunikira pakukula kwake: matenda a impso, chiwindi, ziwalo zopumira, kuchepa magazi, ndi zina zambiri.

Mndandanda wazotsatira zoyipa malinga ndi malangizo:

Kuphwanya	Zizindikiro	Zowonjezera
Hypoglycemia	Kutupa, kupweteka mutu, kugona kwambiri, palpitations.	Kuti athetse kufunika kwa kukonzekera kwamlomo wa 15 g shuga (juwisi, khungubwe la shuga, tiyi wokoma).
Mavuto a chimbudzi	Kuchepetsa mphuno, kusowa kwa chakudya, kulawa pakamwa, kutsekula m'mimba.	Zizindikirozi zimayambitsidwa ndi metformin. Zitha kupewedwa pomachulukitsa mulingo, monga tafotokozera pamwambapa. Malinga ndi ndemanga, mwa anthu ambiri odwala matenda ashuga, matenda ammimba amawonongeka patatha milungu iwiri atamwa Glibomet.
Kuwonongeka kwa chiwindi	Hepatitis, kuchuluka kwa michere ALT, AST.	Maonekedwe a zotsatirapo zoyipazi zingafune kuleka mankhwala. Pankhaniyi, kusintha kwa zamatenda kumatha palokha, nthawi zambiri safuna chithandizo.
Sinthani kapangidwe ka magazi	Sapezeka. Mu kuyesedwa kwa magazi - kuchepa kwa chiwerengero cha leukocytes ndi mapulateleti, kuchepa magazi.
Ziwengo ndi hypersensitivity zigawo zikuluzikulu za mankhwala Glibomet	Khungu loyenda, zotupa, malungo, kupweteka.	Allergies amatha kupangitsa onse omwe amagwira ntchito komanso omwe amapezeka piritsi. Ngati anaphylactic anachita, mankhwalawa amachotsedwa.
Lactic acidosis	Kufooka, kupweteka kumbuyo, minofu, kukokana kwa minofu, kusanza, kupweteka kwam'mimba.	Matendawa ndi owopsa ndi lactic acidotic chikomokere, amafunika kuthetsedwa kwa Glibomet komanso kupempha dokotala mwachangu.
Kuledzera	Mobwerezabwereza zizindikiro za kuledzera: kusanza, kupweteka mutu, kukhathamiritsa, kuthamanga kwa magazi.	Zitha kuchitika ndikumwa Glibomet ndi mowa. Kwa odwala matenda ashuga omwe amamwa mankhwalawa, malangizowo amalimbikitsa kusiya mowa.

Kuopsa kwa zotsatira zosakhudzidwa, kuwonjezera pa hypoglycemia, kumayesedwa ndi malangizo ogwiritsira ntchito ngati osowa (ochepera 0,1%) komanso osowa kwambiri (osakwana 0.01%).

Analogs ndi choloweza

Ma analogi a Glibomet omwe ali ndi mlingo womwewo wa zinthu zomwe zimagwira (2,5 + 400) - Indian Gluconorm ndi Russian Metglib. Zosakaniza zonse za glibenclamide ndi metformin zimakhala ndi mitundu ya 2,5 + 500 ndi 5 + 500, kotero mukasinthira ku mankhwalawa, shuga wanu wamagazi amatha kusintha. Mwinanso, kusintha kwa mlingo kumafunika.

Ma Analogues ku Russia amapangidwa ndi makampani akuluakulu anayi azachipatala - Pharmasintez, Pharmstandart, Kanonfarma ndi Valeant. Malinga ndi ndemanga, mankhwalawa ndiwothandiza ngati Glibomet.

Gulu la mankhwala osokoneza bongo	Dzinalo	Dziko lopanga	Wopanga
Ma analoguine athunthu, kuphatikiza kwa metformin ndi glibenclamide	Glibenfage	Russia	Mankhwala
	Gluconorm Plus		Mankhwala
	Mphamvu ya Metglib		Canonpharma
	Metglib		Canonpharma
	Bagomet Plus		Wodziwika bwino
	Glucovans	France	Merk
	Gluconorm	India	MJ Biopharm
Mapiritsi a Glibenclamide	Statiglin	Russia	Mankhwala
	Glibenclamide		Atoll, Moskhimpharmprep-t, Pharmstandard, Biosynthesis
	Maninil	Germany	Berlin Chemie
	Glimidstad		Khazikika
Kukonzekera kwa Metformin	Metformin	Russia	A George Richter, a Medisorb, a Canon Pharma
	Merifatin		Mankhwala
	Mtundu wautali		Mankhwala
	Glucophage	France	Merk
	Siofor	Germany	Berlin Chemie
Mndandanda wa mfundo zoyenera kuchitira, metformin + sulfonylurea	Glimecomb, Gliclazide + Metformin	Russia	Ahrikhin
	Amaryl, glimepiride + metformin	France	Sanofi

Ngati kuphatikiza mankhwala kulibe mankhwala, akhoza kusintha ndi metformin ndi glibenclamide padera. Ngati mutenga muyezo womwewo, malipiro a matenda a shuga sangakulitse.

Glimecomb ndi Amaril ali pafupi ndi Glibomet ndi makina amachitidwe. Zomwe zimagwira pophatikizika, gliclazide ndi glimepiride, ndizofanizira za gulu la glibenclamide. Amachepetsa shuga pang'ono bwino, koma ndi otetezeka m'maselo a beta.

Malamulo osungira ndi mtengo wake

Glybomet imasunga bwino kwa zaka 3, chinthu chokha chosungira ndicho kutentha osaposa 30 ° C.

Kuyika ma Glibomet kuchokera pamapiritsi 40 kumawononga ma ruble 280-350. Ma analogues a Chefer ndi Gluconorm Plus (mtengo ma ruble 150 ma mapiritsi 30), Gluconorm (ma ruble 220 pa mapiritsi 40), Metglib (210 rubles for 40 pcs.).

Mitundu ya Glibomet

Mankhwalawa, odwala ayenera kutsatira malangizo a dokotala pokhudzana ndi kuchuluka ndi momwe angagwiritsire ntchito mankhwalawo, komanso kutsatira zakudya, kuchita masewera olimbitsa thupi komanso kudziyang'anira pawokha kuchuluka kwa shuga.

Lactic acidosis ndi njira yachilendo komanso yowopsa ya moyo yodziwika ndi kuphatikizika kwa lactic acid m'magazi, omwe mwina amayamba chifukwa cha kuchuluka kwa metformin.

Zofotokozedwa za chitukuko cha lactic acidosis mwa odwala omwe amalandira metformin amawonekera kwambiri mwa odwala omwe ali ndi matenda osokoneza bongo omwe ali ndi vuto lalikulu la mtima komanso aimpso.

Kupewera kwa lactic acidosis kumaphatikizapo kuzindikiritsa zinthu zonse zokhudzana ndi chiopsezo, monga matenda osakhazikika a shuga, ketosis, kusala kudya kwa nthawi yayitali, kumwa kwambiri mowa, kulephera kwa chiwindi ndi vuto lililonse lomwe lingakhale ndi hypoxia.

Mukamamwa mankhwala a Glybomet ®, serum creatinine wozungulira uyenera kuyang'aniridwa nthawi zonse:

• osachepera kamodzi pachaka kwa odwala omwe ali ndi vuto laimpso,
• osachepera 2-4 pachaka odwala omwe ali ndi kuchuluka kwa serum creatinine pafupi ndi VGN, komanso odwala okalamba.

Chenjezo liyenera kuchitika pokhapokha ngati pali vuto laimpso, mwachitsanzo, popereka mankhwala a antihypertensive kapena okodzetsa, kumayambiriro kwa mankhwala a NSAID.

Kuchiza ndi Glibomet ® kuyenera kuyimitsidwa maola 48 asanafike pa X-ray yokhala ndi ma iodini osiyanitsa mitundu ndi kusintha mankhwala ena a hypoglycemic (mwachitsanzo, insulin).

Kugwiritsa ntchito mankhwalawa Glybomet ® kuyenera kuyimitsidwa maola 48 isanachitike opaleshoni yokonzekera, yokhala ndi msana kapena mankhwala opweteka. Mankhwalawa amayenera kupitilizidwa pambuyo poti ayambanso kudya pakamwa kapena osachepera maola 48 atachitidwa opaleshoni, ngati chithandizo chokwanira cha impso chikutsimikiziridwa.

Ethanol imatha kupangitsa chitukuko cha hypoglycemia, komanso kugwiranso ntchito ngati kupuma, kusanza, kupweteka pamimba, kumva kutentha pakhungu la nkhope ndi thupi lakumtunda, tachycardia, chizungulire, kupweteka kwa mutu, chifukwa chake muyenera kupewa kumwa mowa mukamalandira chithandizo ndi Glibomet ®.

Kukopa pa kuyendetsa magalimoto ndi njira zina zofunika kukhudzidwa kwambiri

Mukamamwa Glibomet ®, hypoglycemia imatha kuyamba, ndipo, chifukwa chake, kutsika kwa kuthekera kwambiri komanso kuthamanga kwa ma psychomotor, chifukwa chake, kusamala kuyenera kuchitidwa pakumwa mankhwalawa mukamayendetsa magalimoto, machitidwe ndi kuchita zochitika zoopsa.

Glybomet: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi analogi

Zakudya zokhudzana ndi matenda a shuga zikalephera, dokotala amakupatsani mankhwala okhala ndi metformin kapena glibenclamide.

Ndipo zomwe zili ndi zinthu zonsezi ndizodalirika. Glybomet amatanthauza izi, ngati mumatsatira malangizo ogwiritsa ntchito komanso kusankha kwa endocrinologist.

Mankhwalawa ali ndi zinthu zingapo zomwe zimayenera kuganiziridwa mwatsatanetsatane.

Zotsatira zoyipa

Pali zimachitika zingapo mukamamwa mankhwalawa:

• Hypoglycemia.
• Lactic acidosis.
• Kusanza, kusanza, "zitsulo" mkamwa.
• Mutu.
• Hematopoiesis.
• Khungu limakhudza, kuyabwa, urticaria.
• Zizindikiro za poyizoni wa chakudya mukamamwa mowa.

Fananizani ndi fanizo

Mankhwalawa ali ndi mitundu ingapo yodziwika bwino. Ayenera kuganiziridwa poyerekeza ndi Glybomet ndi katundu wake.

Zomwe zimagwiritsidwa ntchito ndi metformin hydrochloride.

Mtengo umayamba kuchokera ku ma ruble a 130 pazidutswa 30.

Yopangidwa ndi Merck Sante ku France.

Zili pagulu la Biguanides, zimakhala ndi hypoglycemic. Sichimayambitsa hypoglycemia, koma ndiyotsika mtengo.

Zopindulitsa zazikulu - pali zovuta zoyipa ndi zoletsa (pakati, okalamba, ana). Zosagwirizana ndi mowa.

Chothandizira chophatikizika ndi gliclazide.

Mapiritsi awa akuyamba kuchokera ku ma ruble 300.

Kupanga - Service, France.

Amachepetsa shuga la magazi, ali ndi zotsatira zoyipa zochepa. Choyambirira chachikulu ndi mtengo.

Zigawo zikuluzikulu ndi metformin ndi vildagliptin.

Mtengo - kuchokera ku ma ruble 1500 (zidutswa 30 chilichonse).

Yopangidwa ndi Novartis ku Switzerland.

Malinga ndi zomwe ali nazo, iyi ndiye yankho lalitali kwambiri (mpaka maola 24) ndendende chifukwa chophatikiza zinthu. Choyipa chachikulu ndichokwera mtengo komanso kufunikira kwa kayendedwe ka mankhwala, komanso kukhalapo kwa zovuta zambiri.

Monga Glibomet, ndi mankhwala ophatikiza.

Mtengo wake ndi ma ruble 200 pamapiritsi 30.

Production kampani Merck Sante, France.

Chifukwa cha magawo awiriwa, ndi mankhwala othandiza, komanso lilinso ndi mzere wazotsatira zoyipa. Zoletsa zonse pazogwiritsa ntchito zimayenderana ndi zomwe zasonyezedwa ndi Glibomet.

Kupanga kofanana, zinthu ziwiri zogwira ntchito.

Mtengo wake umachokera ku ma ruble 200 (mapiritsi 40).

Kupanga "MJ Biopharm", India.

Malo onse amagwirizana ndi omwe amafotokozedwa ndi Glibomet. Mwa zabwino, mtengo wotsika ungadziwike.

Gawo logwira ntchito ndilofanana ndi Glucofage.

Mtengo umasiyana kuchokera ku ma ruble 120 (zidutswa 30).

Wopanga - "Gideon Richter", Hungary, "Teva", Israel, "Canonfarma", Russia, "Ozone", Russia.

Wothandizirana kwa nthawi yayitali ndi mphamvu yochepetsera shuga. Imapezeka pakugwiritsa ntchito, imagwira ntchito, koma imakumana ndi zovuta ndipo imaletsedwa kwa ana ndi amayi apakati.

Mapiritsi okhala ndi glibenclamide okhala ndi katundu wochepetsera kuchuluka kwa shuga m'thupi.

Mtengo wake ndi ma ruble 120 (mapiritsi a 120).

Yopangidwa ndi Berlin Chemie, Germany.

Kuphatikiza kwakukulu ndi kuchitapo kanthu mwachangu. Koma zimatha kuyambitsa hypoglycemia, ndizoletsedwa kwa amayi apakati ndi ana. Itha kuphatikizidwa ndi mankhwala ena.

Pali malingaliro komanso malingaliro olakwika a odwala matenda ashuga okhudza mankhwalawa. Kukula kwaposowa kwa zotsatira zoyipa kumadziwika, makamaka ngati chithandizo cha zakudya chikutsatiridwa.

Victoria: “Poyamba ndimatenga Glucophage. Koma shuga pang'onopang'ono anasiya kugwa. Dokotala adalimbikitsa "Glibomet". Zotsatira zake ndizodabwitsa, koma pali zovuta zina zingapo. Ngakhale nditatsata kadyedwe, ndiye kuti zonse zili mwadongosolo. "

Dmitry: “Ndinayesa mitundu yosiyanasiyana ya mankhwala. Ndipo muzichita masewera olimbitsa thupi ndi zakudya, komanso kumwa mapiritsi. Pakadali pano, njira yabwino kwambiri ndi Glibomet. Shuga ndi khola, koma akumva bwino. Kuphatikiza apo, cholesterol yatsika. Sindikusangalala kwenikweni. ”

Daria: “Amayi anapezeka ndi matenda a shuga. Zakudyazo zidakhala zopanda ntchito, chifukwa chake, mankhwala adalumikizidwa. Pambuyo poyesa ena onse, Glibomet ndiye yabwino koposa. Amamva bwino, ndipo kuchuluka kwa shuga nthawi zonse kumakhala chimodzimodzi. Pokhapokha kukoma kumatanthauza, pamakhala zovuta zina. "

Glybomet: malangizo ogwiritsira ntchito, mtengo, ndemanga, analogi

Nthawi zambiri pochiza matenda a shuga 2, sikokwanira kugwiritsa ntchito njira imodzi yokha mwaziphuphu. Biguanides ndi mosemphanitsa akuyenera kuwonjezeredwa ku chithandizo cha mankhwala a sulfonylurea.

Madokotala opanga adatha kupanga mankhwala Glibomet, omwe ndi ophatikiza magulu awiri mokwanira, chifukwa cha njira zingapo zotulutsira mavuto, amathetsa mavuto a anthu omwe akudwala matendawa.

Kugwiritsa

Mankhwala a Glibomet adapangidwira kuti azisinthasintha shuga mwa odwala omwe ali ndi matenda ashuga a 2, omwe amayesa kubweretsa shuga kuti akhale abwinobwino ndi chithandizo chamankhwala, kumwa mankhwala ochokera ku sulfonylurea kapena biguanides sikulephera.

The analemba mankhwala zikuphatikizapo 2 yogwira zinthu:

• glibenclamide 2,5 mg - woyimira m'badwo wachiwiri wa sulfonylurea
• Metformin 400 mg ndi zotumphukira za biguanides.

Unyinji wopanga piritsi umayimiriridwa ndi gulu limodzi la omwe akubwera.

Pamwamba pa mapiritsiwo mumakhala zokutira ndi talc ndikuphatikizira amodzi amitundu ya mapadi ndi diethyl phthalate.

Kuchita ndi mankhwala ena

Kuchita ndi mitundu ingapo ya mankhwala kumabweretsa kuwonjezeka kwa zotsatira za hypoglycemic. Izi zikuphatikiza:

• kukonzekera kwa coumarin,
• salicylates,
• opanga beta
• sulfonamides,
• Mao zoletsa
• miconazole
• mowa wa ethyl.

Glibomet imawonjezera mphamvu ya anticoagulants.

Zotsatira zotsutsana za hypoglycemia ndi:

• glucocorticoids,
• kulera kwamlomo
• okodzetsa a mndandanda wa thiazine,
• barbiturates
• adrenaline
• mahomoni a chithokomiro.

Beta blockers mafuta mu chiwonetsero cha matenda a hypoglycemia, zomwe zimakhala zowopsa kwa odwala matenda ashuga.

Othandizira a Iodine omwe amalowetsedwa m'mitsempha amathandizira kuti metformin ipangidwe, chifukwa chake pali chiopsezo cha lactic acidosis.

Pali fanizo la Glibamet pochita ndi kapangidwe kake.

1. Glucovans ndi kuphatikiza kophatikizira kwa hypoglycemic action, yopangidwa ndi Merck, France. Mapiritsi okhala ndi glibenclamide ndi metformin m'matumba a chithuza mapiritsi 15. Mu phukusi 2 kapena 4 matuza.
2. Metglib - ili ndi mawonekedwe ofanana, mapiritsi a zidutswa 40 pa paketi iliyonse.
3. Bagomet-kuphatikiza - zinthu zofanana ziwiriziwiri, koma mlingo wake ndi wosiyana pang'ono. Atanyamula 30 mapiritsi. Wopanga Argentina.
4. Gluconorm - kuphatikiza kwa zinthu ziwiri zomwezo, zidutswa 40 chilichonse, zimaperekedwa kuchokera ku India.
5. Ma analogi a Glibomet omwe ali osiyana mu kapangidwe kake koma ofanana ndi omwewo akuphatikizira:
6. Amaryl yochokera glimepiride 1.2.3.4 mg mu matuza a zidutswa 15, phukusi la matuza 2, 4, 6 kapena 8. Kupezeka ku Germany.
7. Maninil ndi Diabetes - zochokera ku glibenclamide, ndizomwe zimachokera ku 2nd sulfonurea.
8. Maninil - mapiritsi a 1.75 mg, 3.5 mg ndi 5 mg a zidutswa 120. Wopanga - Berlin-Chemie, Germany.
9. Diabeteson MV - mapiritsi 30 kapena 60 mg a mapiritsi a 60 kapena 30, motero. Wantchito Laborator, wogulitsa mankhwala ku France.

Poyerekeza, Maninil - Diabetes ayenera kupatsidwa chidwi ndi Diabetes, ngati mankhwala osavulaza.

Kwa mtengo, Glybomet ndi ma fanizo ake ali mumtundu wofanana.

• Mtengo wapakati pa Glibomed umachokera ku ruble 200 mpaka 300.
• Glucovans - mtengo uli pamtunda wa 250 - 350 rubles.
• Bagomet-plus imagulitsidwa ma ruble 225 -235.
• Metglib ikhoza kugulidwa pafupifupi ma ruble 230.
• Maninil amatenga ma ruble a 130 -170.
• Diabetes mkati mwa malire a 159 - 202 rubles.
• Mtengo wa Amaryl umachokera ku ma 150 mpaka 3400 rubles. Amaryl imagulitsidwa pamtengo wokwera kwambiri pamtundu waukulu wa 4 mg wa mapiritsi 90.

Ndikofunikira kudziwa kuwunika kwa odwala matenda ashuga ku Glibomet.

= http://diabethelp.org/lechim/glibomet-otzyvy-diabetikov.html

Lotov Roman Andreevich amatenga Glibomet 25 mg m'mawa ndi madzulo, chifukwa chake, shuga sichidutsa 4-6 mmol. Kukhutitsidwa ndi zotsatira zake. http://zhivizdorovim.ru/lekarstva/pishchevaritelnyi-trakt/10280-glibomet.html

Irina adagawana kuti atatenga Glibomet mwamuna wake ali ndi mseru komanso kusanza adadziwika mkati mwa sabata, koma koposa zonse, shuga adayamba 10 mpaka 17. http://www.medsovet.info/herb/4279

Malingaliro a endocrinologists pankhani ya ndemanga ya Glybomet amakhala abwino. Ambiri amakhulupirira kuti kusankha kwa mlingo woyenera kumafunikira nthawi kuti wodwalayo awunikidwe kwambiri komanso chifukwa cha kuchuluka kwa shuga, sipangakhale zotsatira zabwino kuchokera pamitengo yoyamba.

Wodwalayo ayenera kumvetsetsa kuti mgwirizano wapafupi ndi adotolo, kutsatira malangizo omwe amamwa mankhwalawo, zakudya, zakudya ndi kuchita masewera olimbitsa thupi ndizofunikira zomwe moyo wake umadalira.

Sungani kapena gawani:

Glibomet: ndemanga za anthu odwala matenda ashuga, mtengo ndi fanizo la mankhwala

Odwala ambiri omwe ali ndi vuto la matenda ashuga ali ndi chidwi chofuna kudziwa kuti ndi mankhwala ati omwe angathandize kwambiri pochiza matendawa.

Chimodzi mwazothandiza kwambiri ndi mankhwala Glibomet, omwe ali ndi shuga yotsika shuga, chifukwa chakuti mumakhala zinthu monga metformin ndi glibenclamide. Kuchulukitsa pakati pazigawo zikuluzikulu za mankhwala glibenclamide ndi metformin ndi 400 mg ndi 2.5 mg, motsatana. Chipangizocho chili ndi zigawo zothandiza.

Zowona, kuti muwonjezere zochizira, muyenera kumvetsetsa momwe mungamwe mankhwalawo molondola.

Mankhwalawa amapezeka mwanjira ya mapiritsi, phukusi limakhala ndi mapiritsi 40, 60 ndi 100.

Ndikofunika kudziwa - mankhwalawa amatengedwa ngati amshuga amitundu iwiri. Chofunikira chachikulu, chomwe ndi gawo lake, chimakhudzanso chinsinsi cha insulini, chimawonjezera kuzindikira kwa mahomoni m'thupi.

Ndikofunikira kuti Glibomet ndi fanizo la mankhwalawa amawonedwe ngati m'badwo watsopano wa mankhwalawa, chifukwa chogwiritsa ntchito imodzi mwazomwe zimagwira - glibenclamide. Glibenclamide ndi kabuku kamene kotsatira, kam'badwo watsopano wachiwiri.

Mitu ya mankhwalawa imakhudzanso thupi ndipo imakhalanso ndi zofanana. Glucophage ikhoza kukhala mankhwala analogue; imakhala ndi glibenclamide ndi metformin.

Ubwino waukulu wa mankhwalawa ndikuti ndimankhwala omwe amathandizika kwa nthawi yayitali, nthawi zambiri amaperekedwa kwa achinyamata ndi ana.

Chifukwa cha kuphatikiza bwino magawo awiriwo, chifukwa chotenga glibenclamide ndi metformin, ndizotheka kukwaniritsa kutsitsa shuga komanso kuthana ndi kunenepa kwambiri. Vuto lolemera kwambiri nthawi zambiri limayendera limodzi ndi matenda a shuga 2.

Kodi ndikofunika kukumbukira chiyani mukamagwiritsa ntchito glibomet?

Musanayambe kugwiritsa ntchito mankhwala Glibomet, malangizowo ayenera kuphunziridwa mwatsatanetsatane, muyenera kuwerengera chithunzi cha mankhwalawo kuti mumvetsetse bwino ngati mankhwalawo agulidwa.

Monga tafotokozera pamwambapa, pali mafanizo ambiri omwe madokotala angalimbikitse. Pakati pawo, mankhwala akuluakulu ndi Glucofage 850. Odwala ambiri amayesa kudziwa kuti ndibwino liti pazithandizo ziwiri izi. Zimakhala zovuta kupereka yankho lenileni. Zonse zimatengera mawonekedwe amunthu wodwala komanso kuopsa kwa matendawo.

Kupezeka kwa matenda opatsirana kumathandizanso kwambiri. Ngati pali zovuta ndi chiwindi, muyenera kusamala mukamapereka mankhwala.

Ndikwabwino pankhaniyi nthawi zonse kumwa mankhwala ofanana omwe amathandizira ntchito ya chiwindi palokha, mwachitsanzo, Essentiale forte. Komanso, kuyanjana kwa mankhwalawa ndi hypoglycemic ndizabwino.

Upangiri womwewo womwe ungaperekedwe pankhani ya mankhwala, omwe akuwonetsa kuti muyenera kutenga glucophage.

Zakhala zikunenedwa pamwambapa kuti Glibomet yayitali sikulimbikitsidwa kuti igwiritsidwe ntchito ndi odwala omwe ali ndi zaka 18. Chifukwa chake, ngati pakufunika kusankha mankhwala kwa mwana, izi zimayenera kuganiziridwa.

Pali zithandizo zambiri zomwe Maninil alipo. Chifukwa chake, nthawi zonse mungasankhe njira yoyenera kwambiri yodwala.

Odwala ena amaganiza kuti Glucophage ndi Glybomet ndi ma syonyms. Koma awa ndi malingaliro olakwika, awa ndi mitundu iwiri yosiyanasiyana ya mankhwala, ngakhale pali kufanana zambiri pakati pawo. Komanso, zonse zikuchokera komanso mogwirizana ndi momwe thupi limakhudzira.

Muyenera kusankha mlingo wa mankhwalawa mosamala kutengera mtundu wa mankhwalawa. Kupatula apo, pali mapiritsi omwe ali ndi 2,5 mg pazomwe zimagwira, ndipo pali zomwe zimaphatikizapo 5 mg ya chinthu chomwecho.

Ndi mankhwala ati a shuga omwe ali othandiza kwambiri akufotokozedwa mu kanema munkhaniyi.

Sonyezani shuga yanu kapena sankhani jenda pamayendedwe Akusaka Osapezeka Kusaka sakupeza Kusaka sikupezeka

Hypoglycemic m`kamwa mankhwala a gulu lachiwiri Glybomet

Pafupifupi 6% ya anthu padziko lapansi masiku ano ali ndi matenda a shuga - matenda omwe chizindikiro chawo chachikulu ndi kuchuluka kwa shuga m'magazi. Zinthu zakunja zimathandizira kukula kwa matendawa; genetics imathandizanso.

Chithandizo chabwino cha matenda ashuga ndichakudya chamafuta ochepa: ngati munthu wabwinobwino amatha kudya mpaka 400 g wamafuta ochepa patsiku, ndiye kuti shuga ndiwosakwana 85 g.

Koma ngakhale kukanidwa kwa chimanga, mbatata, makeke, masamba ambiri ndi zipatso ndikuzisintha ndi mafuta a nyama omwe samakulitsa glucometer, si aliyense angalipire glycemia kwathunthu. Izi zimachitika makamaka kwa odwala matenda ashuga omwe ali ndi mtundu wachiwiri wa matenda, omwe mbiri yakulephera kwa impso.

Pochiza matenda ashuga, mitundu inayi ya mankhwala yapangidwa yomwe imasiyana pakapangidwe kake komanso njira yodziwira vutoli.

1. Mankhwala omwe amachepetsa kuchuluka kwa insulin kukokana ndi maselo ndi biguanides (Metformin, Glucofage) ndi thiazolidinediones (Pioglitazone, Rosiglitazone).
2. Pancreatic synthesis zokuthandizira amkati insulin ndi zotumphukira za sulfanylureas (Diabetes, Maninil) ndi dongo.
3. Mankhwala a mndandanda wa maretretin, owongolera kulemera ndi chilakolako cha chakudya - Galvus, Januvia, Onglisa, Viktoza, Bayeta.
4. Mankhwala omwe amatchinga kunyamula shuga m'matumbo ndi Acarbose, Glucobay.

Glybomet imatchulidwanso kukonzekera kwa pakamwa kwa gulu lachiwiri, malangizo ogwiritsira ntchito omwe aperekedwenso kuti awunikenso. Chidziwitso chonse chimatengedwa kuchokera kumagulu omwe amapezeka pagulu, kotero si chida chodzipezera tokha komanso kudzithandiza nokha.

Matenda a shuga ndi matenda okhalitsa omwe ali ndi zovuta zoopsa pamoyo, ndipo kuyesa mankhwala osafunsira kwa endocrinologist ndikuwunika mozama sikuvomerezeka.

Glybomet - kapangidwe

Kuphatikizidwa mu piritsi lililonse la mankhwala awiri omwe amagwira ntchito - metformin hydrochloride (400 mg) ndi glibenclamide (2.5 mg) zimapangitsa kuti azitha kupewa glycemia, komanso kuchepetsa mlingo wa magawo. Ngati aliyense wa iwo atagwiritsidwa ntchito ngati monotherapy, mlingo wake umakhala wokwera kwambiri.

Ili ndi chilinganizo ndi maipi mu mawonekedwe a cellulose, wowuma chimanga, colloidal silicon dioksidi, gelatin, glycerin, talc, magnesium stearate, acetylphthalyl cellulose, diethyl phthalate.

Zotsatira za pharmacological

Chimodzi mwazinthu zazikulu zomwe zimagwira, glibenclamide, ndi mankhwala a kalasi yamakono ya sulfonylurea, yomwe imaphatikizidwa mndandanda wa mankhwala ofunikira okhala ndi pancreatic ndi zowonjezera pancreatic.

Sizimangoyambitsa ntchito ya kapamba konse, komanso zimathandizira kupanga insulin. Limagwirira ntchito yawo imakhazikika poteteza ma pancreatic β-cell owonongeka ndi glucose ankhanza, omwe amawonetsa kupitilira kwa shuga, komanso kukondoweza kwa insulini kumva kwa maselo aku chandamale.

Kutenga Glibomet mogwirizana ndi glycemic control kumachepetsa kagayidwe ka lipid komanso kumachepetsa chiopsezo cha magazi. Ntchito ya insulin imawonjezeka, ndipo limodzi nawo mayamwidwe a glucose ndim minofu ndi chiwindi. Mankhwala amagwira gawo lachiwiri ndikupanga insulin.

Metformin ndi ya biguanides - kalasi ya zinthu zopatsa mphamvu zomwe zimachepetsa kusagwirizana kwa maselo akhungu kupita ku insulin yawoyawo. Kubwezeretsa kumva sikulinso kofunikira kuposa kupititsa patsogolo katulutsidwe ka timadzi tambiri, chifukwa ndi matenda amtundu wa 2, kapamba amatulutsa ngakhale ochulukirapo.

Metformin imathandizira kulumikizana kwa ma receptors ndi insulin, imawonjezera mphamvu ya postreceptor. Pakakhala insulin m'magazi, zozizwitsa zimawonetsedwa.

Metformin ili ndi mawonekedwe apadera:

• Imachepetsa kuyamwa kwa glucose ndimatumbo amimba ndikuthandizira kugwiritsidwa ntchito kwake mu minofu,
• Zoletsa gluconeogeneis,
• Kuteteza b-cell ku apoptosis yothamanga,
• Amachepetsa chiopsezo cha mtundu uliwonse wa acidosis komanso matenda oopsa,
• Amasintha kukhathamiritsa kwa madzi am'magazi, ntchito ya endothelial ndi metabolism yamafuta (amachepetsa kuchuluka kwa cholesterol "yoyipa" ndi triglycerol m'magazi),
• Amathandizira kuchepa kwa thupi - chinthu chofunikira pakulamulira kwamatenda a mtundu wa 2 mtundu wa DS,
• Kuchepetsa magazi kufupika ndi oxidative nkhawa,
• Ili ndi fibrinolytic zotsatira poletsa minofu ya plasminogen activator,
• Imalepheretsa njira za oncological (kwakukulu, matenda a shuga amawonjezera chiopsezo cha oncology ndi 40%),
• Amachepetsa chiopsezo cha imfa kuchokera ku zochitika zamtima.

Kuunikiridwa mozama kwa odwala matenda ashuga a 5800 omwe ali ndi matenda a shuga a 2 adachitika ku China. Otenga nawo mbali pachiyeso adalandira metformin kuphatikizira ndi kusintha kwa moyo. Gulu lolamulira, odzipereka anangosintha moyo wawo. Kwa miyezi isanu ndi umodzi, mgulu loyamba, kufa anali anthu 7.5 pa anthu 1000 / zaka, chachiwiri - kwa miyezi 45, anthu 11, motsatana.

Mwambiri, pagululi lomwe limalandira metformin ,imfa inali yotsika ndi 29,5% kuposa momwe amawongolera, ndipo pafupipafupi zochitika zamtima zinali 30-35%.

Mankhwalawa amayamba kugwira ntchito maola awiri atalowa m'mphepete, mphamvu yake imapangidwa kwa maola 12. Metformin siziwopseza hypoglycemic.

Mankhwala okhala ndi umboni wokwanira, wadutsa mayeso okhazikika a nthawi ndipo amafunikira matenda ashuga pamilingo yonse yolimbikitsira mankhwala.