Fomu ya Mlingo: mapiritsi okhala ndi filimu Piritsi limodzi lachifundo 1 Mlingo wa 2.5 mg + 500 mg: Zogwira ntchito: glibenclamide - 2,5 mg, metformin hydrochloride - 500 mg. Kernel: croscarmellose sodium - 14,0 mg, povidone K 30 - 20,0 mg, microcrystalline cellulose - 56,5 mg, magnesium stearate - 7.0 mg. Chigoba: opadry OY-L-24808 pinki - 12.0 mg: lactose monohydrate - 36.0%, hypromellose 15cP - 28.0%, titanium dioxide - 24.39%, macrogol - 10,00%, iron iron oxide, 1, 30%, iron oxide ofiira - 0,3%, iron oxide wakuda - 0,010%, madzi oyeretsedwa - q Mlingo 5 mg + 500 mg: Zogwira ntchito: glibenclamide - 5 mg, metformin hydrochloride - 500 mg. Kernel: croscarmellose sodium - 14,0 mg, povidone K 30 - 20,0 mg, microcrystalline cellulose - 54.0 mg, magnesium stearate - 7.0 mg. Chigoba: Opadry 31-F-22700 chikasu - 12,0 mg: lactose monohydrate - 36.0%, hypromellose 15 cP - 28.0%, titanium dioxide - 20.42%, macrogol - 10,00%, utoto wa quinoline wachikasu - 3 , 00%, chitsulo oxide chikasu - 2.50%, red oxide red - 0.08%, madzi oyeretsedwa - qs. Kufotokozera
Mlingo wa 2.5 mg + 500 mg: mapiritsi okhala ndi biconvex wopangidwa ndi kapisozi, wokutidwa ndi utoto wamafilimu amtundu wowala wa lalanje, wokhala ndi "2,5" mbali imodzi.
Mlingo 5 mg + 500 mg: mapiritsi okhala ndi biconvex wopangidwa ndi kapisozi, wokutidwa ndi utoto wakanema wachikasu, wolemba "5" mbali imodzi. MankhwalaGlucovans ® ndi kuphatikiza kosakanikirana kwa othandizira awiri am'magazi a hypoglycemic pamagulu osiyanasiyana a pharmacological: metformin ndi glibenclamide. Metformin ndi ya gulu la Biguanides ndipo amachepetsa zomwe zimakhala ndi basal ndi postprandial glucose m'magazi a m'magazi. Metformin simalimbikitsa kubisirana kwa insulin chifukwa chake siyambitsa hypoglycemia. Ili ndi njira zitatu: amachepetsa kupanga shuga wa chiwindi poletsa gluconeogeneis ndi glycogenolysis,kumawonjezera kukhudzika kwa zotumphukira zolandilira ku insulin, kumwa ndi kugwiritsa ntchito shuga m'maselo a m'mitsempha,Iachedwetsa mayamwidwe am'magazi m'mimba.Mankhwalawa alinso ndi phindu pakapangidwe ka lipid m'magazi, kuchepetsa kuchuluka kwa cholesterol, otsika kachulukidwe lipoproteins (LDL) ndi triglycerides. Metformin ndi glibenclamide zimakhala ndi njira zosiyanasiyana zochitira zinthu, koma zimathandizana wina ndi mnzake pogwira ntchito. Kuphatikizidwa kwa ma othandizira awiri a hypoglycemic kumathandizira pakuchepetsa shuga. PharmacokineticsGlibenclamide. Mukamamwa pakamwa, mayamwidwe kuchokera m'matumbo am'mimba amaposa 95%. Glibenclamide, yomwe ndi gawo la mankhwalawa Glucovans ® imakhala micron. Kuchuluka kwa kuchuluka kwa plasma kumafikira pafupifupi maola 4, kuchuluka kwa magawidwe kuli pafupifupi malita 10. Kuyankhulana ndi mapuloteni a plasma ndi 99%. Imakhala ngati imaphatikizidwa kwathunthu m'chiwindi ndikupanga ma metabolites awiri osagwira, omwe amatsitsidwa ndi impso (40%) komanso bile (60%). Kutha kwa theka-moyo ndikuchokera maola 4 mpaka 11. Metformin pambuyo pakamwa makonzedwe, zimatengedwa kuchokera m'mimba thirakiti kwathunthu, kuchuluka kwa ndende mu plasma kumachitika mkati mwa maola 2,5. Pafupifupi 20-30% ya metformin imapukusidwa kudzera m'matumbo osasinthika. Mtheradi bioavailability kuchokera 50 mpaka 60%. Metformin imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma. Amapangidwira pamlingo wofooka kwambiri ndikuwonetsa impso. Kuchotsa theka-moyo ndi pafupifupi maola 6.5. Ngati aimpso ntchito, aimpso chilolezo amachepetsa, monga creatinine chilolezo, pomwe kuwonongedwa theka moyo kumawonjezereka, zomwe zimabweretsa kuchuluka kwa metformin m'magazi a magazi. Kuphatikiza kwa metformin ndi glibenclamide mu mtundu womwewo wa mapangidwewo kuli ndi bioavailability yomweyo ngati mukumwa mapiritsi okhala ndi metformin kapena glibenclamide patokha. The bioavailability ya metformin kuphatikiza ndi glibenclamide sichikhudzidwa ndi chakudya, komanso bioavailability wa glibenclamide. Komabe, kuchuluka kwa mayamwa a glibenclamide kumawonjezera ndi chakudya. Zisonyezero zogwiritsidwa ntchito:
Type 2 shuga mwa akulu:
ndi kuperewera kwa mankhwala othandizira kudya, masewera olimbitsa thupi komanso monotherapy yapitayi ndi metformin kapena zotumphukira za sulfonylurea,m'malo mankhwalawa m'mbuyomu ndimankhwala awiri (metformin ndi sulfonylurea derivative) mwa odwala omwe ali ndi khola komanso glycemia yokhazikika.Zoyipa:Hypersensitivity kuti metformin, glibenclamide kapena zina zotumphukira za sulfonylurea, komanso zinthu zothandiza,mtundu 1 shugamatenda ashuga ketoacidosis, matenda a shuga, matenda ashuga,Kulephera kwaimpso kapena kuwonongeka kwaimpso (kulengedwa kwa creatinine zosakwana 60 ml / min),Mikhalidwe yovuta kwambiri yomwe ingayambitse kusintha kwa impso: kuchepa madzi m'thupi, kudwala kwambiri, kuopa, kuyambitsa matenda a iodine okhala ndi ayodini (onani "Maupangiri Apadera"),matenda owopsa kapena osakhazikika omwe amayenda ndi minofu hypoxia: kulephera kwa mtima kapena kupuma, kulowetsedwa kwaposachedwa, kugwedezeka,kulephera kwa chiwindiporphyriamimba, yoyamwitsa,kugwiritsa ntchito miconazole,opaleshoni yayikuluuchidakwa wambiri, kuledzeralactic acidosis (kuphatikizapo mbiri),kutsatira zakudya zochepa zama calori (zosakwana 1000 calories / tsiku),Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa mwa anthu opitirira zaka 60 omwe amagwira ntchito zolimbitsa thupi, zomwe zimagwirizanitsidwa ndi chiwopsezo chokhala ndi lactic acidosis mwa iwo. Glucovans ® imakhala ndi lactose, chifukwa chake sagwiritsiridwa ntchito osavomerezeka kwa odwala omwe ali ndi matenda amtundu wothandizidwa ndi galactose tsankho, kuchepa kwa lactase kapena glucose-galactose malabsorption. Ndi chisamaliro: febrile syndrome, adrenal insufficiency, hypofunction ya anterior pituitary, matenda a chithokomiro ndikuphwanya kwa ntchito yake. Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa
Kugwiritsa ntchito mankhwalawa kumapangidwa pakakhala pakati. Wodwalayo ayenera kuchenjezedwa kuti panthawi ya chithandizo ndi Glucovans ® ndikofunikira kudziwitsa dokotala za mimba yomwe yakonzekereratu komanso nthawi yomwe mayi adzakhale ndi pakati. Pokonzekera kutenga pakati, komanso ngati mukukhala ndi pakati panthawi yomwe mukumwa mankhwalawa Glucovans ®, mankhwalawa ayenera kusiyidwa, ndipo chithandizo cha insulin chimayikidwa. Glucovans ® imaphatikizidwa pakamayamwa, popeza palibe umboni wa kuthekera kwake kudutsa mkaka wa m'mawere. Mlingo ndi makonzedweMlingo wa mankhwalawa umatsimikiziridwa ndi dokotala aliyense payekha kwa wodwala aliyense, kutengera mlingo wa glycemia. Mlingo woyambirira ndi piritsi limodzi la mankhwala Glucovans ® 2.5 mg + 500 mg kapena Glucovans ® 5 mg + 500 mg kamodzi patsiku. Popewa hypoglycemia, mlingo woyambirira sayenera kupitirira muyeso ya tsiku ndi tsiku ya glibenclamide (kapena mlingo wofanana wa mankhwala ena omwe kale anali kumwa sulfonylurea) kapena metformin, ngati agwiritsidwa ntchito ngati mankhwala oyambira. Ndikulimbikitsidwa kuti mlingo uonjezeke osapitirira 5 mg ya glibenclamide + 500 mg ya metformin patsiku lililonse pakapita milungu iwiri kapena kupitirira kuti magazi azitha kuyamwa. Mothandizidwa ndi chithandizo cham'mbuyomu ndi metformin ndi glibenclamide: Mlingo woyambirira suyenera kupitirira tsiku ndi tsiku mlingo wa glibenclamide (kapena mlingo wofanana wa sulfonylurea kukonzekera) ndi metformin yomwe idatengedwa kale. Pakatha masabata awiri kapena angapo atayamba kumwa mankhwalawa, mankhwalawa amasinthidwa malinga ndi glycemia. Pazipita tsiku lililonse mapiritsi 4 a mankhwala Glucovans ® 5 mg + 500 mg kapena mapiritsi 6 a mankhwala Glucovans ® 2.5 mg + 500 mg. Malangizo:
Mlingo wa miyeso umatengera cholinga cha munthu payekha: Mlingo wa 2.5 mg + 500 mg ndi 5 mg + 500 mg Kamodzi patsiku, m'mawa nthawi ya chakudya cham'mawa, ndikupatsidwa piritsi limodzi patsiku.Kawiri pa tsiku, m'mawa ndi madzulo, ndi mapiritsi awiri kapena anayi patsiku.Mlingo wa 2.5 mg + 500 mg Katatu patsiku, m'mawa, masana ndi madzulo, ndimapiritsi atatu, 5 kapena 6 patsiku. Mlingo wa 5 mg + 500 mg Katatu patsiku, m'mawa, masana ndi madzulo, ndi mapiritsi atatu patsiku. Mapiritsi ayenera kumwedwa ndi zakudya. Chakudya chilichonse chimayenera kutsagana ndi chakudya chokhala ndi chakudya chokwanira chomanga thupi kuti mupewe kuchitika kwa hypoglycemia. Odwala okalamba
Mlingo wa mankhwalawa amasankhidwa kutengera mtundu wa impso. Mlingo woyambirira sayenera kupitilira piritsi limodzi la mankhwala Glukovans ® 2.5 mg + 500 mg. Kuwunika pafupipafupi kwa impso ndikofunikira. Ana
Glucovans ® sikulimbikitsidwa kuti igwiritsidwe ntchito mwa ana. Zotsatira zoyipaZotsatira zoyipa izi zitha kuchitika mukamalandira chithandizo ndi Glucovans ®. Pafupipafupi mavuto a mankhwala amawerengeredwa motere:
Nthawi zambiri: ≥ 1/10
Pafupipafupi: ≥ 1/100, ® iyenera kuletsedwa. Chithandizo chikulimbikitsidwa kuti chithandizidwenso pambuyo pa maola 48, ndipo pokhapokha ngati ntchito ya impso imayesedwa ndikuvomerezedwa kuti ndi yachibadwa. Impso
Popeza metformin imachotsedwa impso, ndipo nthawi zambiri pambuyo pake, ndikofunikira kudziwa chidziwitso cha creatinine komanso / kapena mawonekedwe a serum creatinine: osachepera kamodzi pachaka kwa odwala omwe ali ndi vuto laimpso, komanso kawiri pachaka odwala okalamba komanso odwala omwe ali ndi creatinine chilolezo pamwambo wapamwamba kwambiri. Kusamalitsa kwakukulu kumalimbikitsidwa panthawi yomwe ntchito ya impso ingakhale yodwala, mwachitsanzo, odwala okalamba, kapena ngati mankhwala oyambitsa antihypertensive, kugwiritsa ntchito okodzetsa kapena mankhwala osapweteka a antiidal (NSAIDs). Njira zina zopewera
Wodwalayo ayenera kudziwitsa dokotala za mawonekedwe a matenda a bronchopulmonary kapena matenda opatsirana. Kukopa pa kuyendetsa galimoto ndikugwira ntchito ndi zinthu
Odwala ayenera kudziwitsidwa za chiopsezo cha hypoglycemia ndipo ayenera kusamala poyendetsa ndi kugwiritsa ntchito njira zomwe zimafuna kuti anthu azisamalira komanso azithamanga kwambiri. WopangaMERC SANTE SAAS
MERCK SANTE s.a.s. Adilesi yovomerezeka:
37 rue Saint-Romain, 69379 LION SEDEX 08, France
37 rue Saint Romain, 69379 LYON CEDEX 08, France Adilesi yoyambira:
Center de Production SEMOIS, 2 rue du Pressoire Ver, 45400 SEMOIS, France
Center de Production SEMOY, 2 rue du Pressoir Vert, 45400 SEMOY, France Zodandaula za ogula ziyenera kutumizidwa kwa:
LLC Nycomed Distribution Center
119048 Moscow, st. Usacheva, d. 2, p. 1
Adilesi ya pa intaneti: www.nycomed.ru Zomwe zili patsamba lino zinatsimikiziridwa ndi katswiri wazachipatala Vasilieva E.I. Zolemba zosangalatsaMomwe mungasankhire analog yoyenera
Mu pharmacology, mankhwala nthawi zambiri amagawidwa m'magulumagulu ndi ma analogi. Kapangidwe kazofananira kameneka kamaphatikizira amodzi kapena angapo amomwe omwewo omwe ali ndi mphamvu yothandizira thupi. Ndi ma analogi amatanthauza mankhwala okhala ndi zinthu zosiyanasiyana zogwira ntchito, koma zochizira matenda omwewo. Kusiyana pakati pa matenda a ma virus ndi bakiteriya
Matenda opatsirana amayambitsidwa ndi ma virus, mabakiteriya, bowa ndi protozoa. Njira ya matenda oyambitsidwa ndi ma virus ndi ma bacteria nthawi zambiri imakhala yofanana. Komabe, kusiyanitsa chomwe chimayambitsa matendawa kumatanthauza kusankha njira yoyenera yomwe ingathandize kuthana ndi misala komanso sikuvulaza mwana. Chifuwa ndi chomwe chimayambitsa chimfine pafupipafupi
Anthu ena amadziwa zomwe zimachitika nthawi zambiri ngati mwana ali ndi chimfine. Makolo amamutengera kwa madotolo, kukamuyeza mayeso, kugwiritsa ntchito mankhwala osokoneza bongo, ndipo monga chotulukapo chake, mwana amalembetsa kale ndi dotolo wa ana monga nthawi zambiri amadwala. Zoyambitsa zenizeni za kupuma pafupipafupi sizidziwika. Urology: mankhwalawa a chlamydial urethritis
Chlamydial urethritis nthawi zambiri imapezeka pochita urologist. Amayambitsidwa ndi majeremusi a Chlamidia trachomatis, omwe ali ndi mphamvu ya mabakiteriya komanso mavairasi, omwe nthawi zambiri amafunikira njira yothandizira antibacterial. Imatha kuyambitsa kutupa kosakhudzana ndi urethra mwa amuna ndi akazi.
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