Diabeteson mv malangizo, ntchito, contraindication, mavuto, ndemanga

Oral hypoglycemic mankhwala ochokera pagulu la sulfonylurea zotumphukira za m'badwo wachiwiri.
Kukonzekera: DIABETON® MV
The yogwira mankhwala: gliclazide
ATX Encoding: A10BB09
KFG: Oral hypoglycemic mankhwala
Nambala yolembetsa: P No. 011940/01
Tsiku lolembetsa: 12.29.06
Mwini reg. ID.: Les Laboratoires SERVIER

Kumasulidwa mawonekedwe a shuga, mv.

Mapiritsi osintha osinthika ndi oyera, oblong, olembedwa mbali zonse ziwiri: kumbali yake pali chizindikiro cha kampaniyo, inayo - DIA30.

1 tabu
gliclazide
30 mg

Omwe amathandizira: calcium hydrogen phosphate dihydrate, maltodextrin, hypromellose, magnesium stearate, anhydrous colloidal silicon dioxide.

30 ma PC - matuza (1) - mapaketi a makatoni.
30 ma PC - matuza (2) - mapaketi a makatoni.

Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Dongosolo la shuga Diabeteson mv

Mankhwala am'magazi a hypoglycemic kuchokera pagulu la sulfonylurea ofanana ndi a m'badwo wachiwiri, omwe amasiyana ndi mankhwala omwewo mwa kukhalapo kwa mphete ya heterocyclic ya N yokhala ndi endocyclic.

Diabeteson MB imachepetsa shuga m'magazi ndikulimbikitsa kubisala kwa insulin ndi ma cell a Langerhans. Pambuyo pa chithandizo chazaka ziwiri, odwala ambiri samayamba kumwa mankhwala osokoneza bongo (kuchuluka kwa insulin ndikubisalira kwa C-peptides kumakhalabe.

Mtundu wachiwiri wa matenda ashuga a mellitus (osadalira insulini), mankhwalawa amabwezeretsa chiyambi champhamvu cha insulin poyankha kukhudzana ndi shuga ndikupangitsa gawo lachiwiri la insulin kutulutsa. Kuwonjezeka kwakukulu kwa insulin katulutsidwe kumawonedwa poyankha kukondoweza chifukwa cha zakudya zomwe amapatsa ndi shuga.

Gliclazide ili ndi kutchulidwa kwa extrapancreatic zotsatira, i.e. kumawonjezera kumverera kwa zotumphukira zimakhala kuti insulin.

Mu minofu yamatenda, mphamvu ya insulin pakumveka kwa glucose, chifukwa cha kusintha kwamphamvu kwa zotumphukira zimakhala ku insulin, kumakulitsidwa kwambiri (+ 35%). Kuchuluka kwa gliclazide makamaka kumachitika chifukwa kumalimbikitsa zochita za insulin pa minofu ya glycogen synthetase ndipo zimayambitsa kusintha kwa post-transcriptal ku GLUT4 wachibale.

Diabeteson MB imachepetsa mapangidwe a shuga m'chiwindi, imapangitsa matenda a shuga kusala.

Kuphatikiza apo zimakhudza kagayidwe kazakudya, gliclazide imathandizanso kukoka kwa microc. Mankhwala amachepetsa chiopsezo cha mtsempha wamagazi ochepa mtima endothelial ntchito ndi kuchuluka kwa minofu plasminogen activator.

Gliclazide ili ndi antioxidant katundu: imachepetsa mulingo wa lipid peroxides mu plasma, imawonjezera ntchito ya maselo ofiira am'magazi a superoxide dismutase.

Pharmacokinetics wa mankhwala.

Zogulitsa ndi kugawa

Mutatha kumwa mankhwalawo mkati, gliclazide imatenga gawo lonse la chakudya. Kuchulukana kwa gliclazide mu madzi a m'magazi kumawonjezeka pang'onopang'ono, mpaka kukafika kumapiri patatha maola 6 mpaka 6. Kudya sizimakhudza kuchuluka kwa mayamwidwe. Kusiyanasiyana kwamunthu aliyense kumakhala kotsika. Ubale pakati pa kumwa ndi plasma ndende ya mankhwalawa ndizodalira nthawi.

Mlingo umodzi wa tsiku ndi tsiku wa Diabeteson MB 30 mg umapatsa plasma ya glycazide yoposa maola 24.

Kuphatikiza kwa mapuloteni a Plasma ndi 95%.

Gliclazide imapangidwa makamaka mu chiwindi. Zotsatira zake za metabolites zilibe zochitika za pharmacological.

T1 / 2 ili pafupifupi maola 16 (maola 12 mpaka 20). Imafufutidwa makamaka ndi impso mu mawonekedwe a metabolites, osakwana 1% - ndi mkodzo mu mawonekedwe osasinthika.

Mlingo ndi njira ya mankhwala.

Mankhwalawa amapangidwira achikulire okha (kuphatikizapo odwala azaka 65 ndi akulu). Mlingo woyambira wabwino ndi 30 mg.

Kusankhidwa kwa Mlingo uyenera kuchitika molingana ndi mulingo wa shuga m'magazi atangoyamba chithandizo. Kusintha kwa mtundu wina uliwonse kumachitika pambuyo pa milungu iwiri.

Ndi mankhwala akukonzanso, tsiku lililonse munthu amathandizira kuwononga kwamisempha. Mlingo wa tsiku ndi tsiku wa mankhwalawa umatha kukhala 30 mg (1 tabu.) Mpaka 90-120 mg (3-4 tabu.). Mlingo wapamwamba tsiku lililonse ndi 120 mg.

Mankhwala amatengedwa pakamwa 1 nthawi / tsiku ladzutsa.

Mukaphonya mtundu umodzi kapena zingapo za mankhwalawa, simungatenge kumwa kwakukulu muyezo lotsatira.

Kwa odwala omwe sanalandire chithandizo, mlingo woyambayo ndi 30 mg. Ndiye kuti mankhwalawa amasankhidwa payekhapayekha mpaka njira yothandizidwa itakwaniritsidwa.

Diabeteson MV amatha m'malo mwa Diabeteson mu 1 mpaka 4 mapiritsi / tsiku.

Kusintha kuchokera ku mankhwala ena a hypoglycemic kupita ku Diabeteson MB sikutanthauza kusintha kwa nthawi. Muyenera kaye kusiya kumwa mankhwala a hypoglycemic ndikumupatsa mankhwala a Diabeteson MB okha.

Diabeteson MB ikhoza kugwiritsidwa ntchito limodzi ndi biguanides, alpha-glucosidase inhibitors kapena insulin.

Kwa odwala okalamba, Mlingo wolimbikitsidwa ndi wofanana ndi wa odwala osakwana zaka 65.

Ngati wodwalayo alandila chithandizo kale ndi mankhwala a sulfonylurea omwe amakhala ndi T1 / 2 mwachitsanzo, chlorpropamide), ndiye kuti kuwunika mosamala (kuwongolera glycemia level) ndikofunikira kwa masabata a 1-2 kupewa kupewa kwa hypoglycemia chifukwa chotsatira chotsalira cha chithandizo cham'mbuyomu.

Odwala omwe ali ndi vuto lochepa kwambiri laimpso (CC kuchokera pa 15 mpaka 80 ml / mphindi), mankhwalawa amapatsidwa mankhwala omwewo ngati odwala omwe ali ndi vuto laimpso.

Zotsatira zoyipa diabeteson mv:

Kuchokera ku endocrine system: hypoglycemia ndiyotheka.

Pa gawo la chakudya cham'mimba: nseru, kutsegula m'mimba kapena kudzimbidwa ndizotheka (osawonedwa kawirikawiri pamene mankhwalawa adayikidwa pakudya), osowa - kuchuluka kwa AST, ALT, phosphatase ya alkaline, nthawi zina - jaundice.

Kuchokera ku hemopoietic dongosolo: kawirikawiri - kuchepa magazi, leukopenia, thrombocytopenia.

Thupi lawo siligwirizana: kawirikawiri - kuyabwa, urticaria, zotupa za maculopapular.

Zotsatira zamankhwala:

- matenda a shuga a mtundu 1 (wodalira insulin),

- matenda ashuga ketoacidosis, matenda a shuga, matenda a shuga,

Kulephera kupweteka kwambiri,

- munthawi yomweyo miconazole,

- mkaka wa m'mawere (yoyamwitsa),

- ana ndi achinyamata osakwana zaka 18,

- Hypersensitivity to gliclazide kapena aliyense wokonda mankhwala, zotumphukira zina za sulfonylurea.

Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa limodzi ndi phenylbutazone kapena danazole.

Gwiritsani ntchito pa nthawi yoyembekezera

Palibe zambiri zachipatala zomwe zingawunike kuopsa kwa malformations omwe angachitike komanso zotsatira za fetotoxic chifukwa chogwiritsa ntchito gliclazide pa nthawi yomwe ali ndi pakati. Chifukwa chake, kugwiritsa ntchito Diabeteson MV m'gulu lino la odwala ndi motsutsana.

Mimba ikachitika pamene mukumwa mankhwalawa, palibe chifukwa chotsimikizika chotsirizira kwake. Zikatero, komanso pakakhala kuti mwakonzekera kuti mukhale ndi pakati, mankhwalawo amayenera kusiyidwa ndipo chithandizo chokwanira chiyenera kupitilizidwa ndi kukonzekera kwa insulini kuyang'aniridwa mosamala kwambiri kwa ziwonetsero zonse za labotale. Kuyanʻanila kwamatenda a shuga m'magazi kumalimbikitsidwanso.

Sizikudziwika ngati gliclazide yachotsedwa mkaka wa m'mawere, palibe umboni uliwonse womwe ungachititse kuti neonatal hypoglycemia ikhale. Pankhani imeneyi, mankhwala a gliclazide panthawi yoyamwitsa amakhala otsutsana.

Pakafukufuku wa nyama, zawonetsedwa kuti zinthu zochokera ku sulfonylurea mu utali waukulu zimakhala ndi teratogenic.

Malangizo apadera ogwiritsira ntchito Diabeteson mv.

Mukamapereka mankhwala a Diabeteson MB, ziyenera kukumbukiridwa kuti hypoglycemia imatha kukhala chifukwa chotenga zinthu zochokera ku sulfonylurea, ndipo nthawi zina zimakhala zovuta komanso zimatenga nthawi yayitali, zomwe zimafuna kugonekedwa kwa chipatala ndi shuga kwa masiku angapo.

Kuti mupewe kukula kwa hypoglycemia, kusankha odwala mosamala komanso kusankha kwa anthu, komanso kupatsa wodwalayo chidziwitso chonse chamankhwala omwe akufunika, ndikofunikira.

Mukamagwiritsa ntchito mankhwala a hypoglycemic mwa odwala okalamba, anthu omwe nthawi zonse samalandira zakudya zokwanira, chifukwa chofooka chofooka, odwala omwe ali ndi adrenal kapena pituitary insuffence, chiopsezo chokhala ndi hypoglycemia chikuwonjezeka.

Zizindikiro za hypoglycemia ndizovuta kudziwa okalamba komanso odwala omwe amalandila chithandizo cha beta-blocker.

Popereka mankhwala a Diabeteson MV kwa okalamba, kuwunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira. Kuchiza kuyenera kuyambitsidwa pang'onopang'ono ndipo masiku oyamba a mankhwalawa ndikofunikira kuthana ndi shuga komanso mutatha kudya.

Diabeteson MB imatha kutumikiridwa kokha kwa odwala omwe amalandira chakudya chokhazikika, chomwe chimaphatikizapo chakudya cham'mawa komanso chokwanira kudya chakudya. Hypoglycemia nthawi zambiri imayamba kudya zakudya zochepa zopatsa mphamvu, pambuyo pochita masewera olimbitsa thupi kwa nthawi yayitali kapena mwamphamvu, mutamwa mowa, kapenanso kumwa mankhwala angapo a hypoglycemic nthawi imodzi.

Zizindikiro za cholestatic jaundice zikaonekera, chithandizo chake chiyenera kusokonezedwa. Pambuyo pakutha kwa Diabeteson MB, zizindikiro izi nthawi zambiri zimatha.

Odwala omwe ali ndi vuto lalikulu la hepatic komanso / kapena aimpso, kusintha kwa pharmacokinetic ndi / kapena pharmacodynamic zimatha gliclazide. Makamaka, kulephera kwambiri kwa hepatic kapena aimpso kungakhudze kugawa kwa gliclazide m'thupi. Kuperewera kwa hepatatic kungathandizenso kuchepetsa glucogeneis. Zotsatira izi zimawonjezera mwayi wokhala ndi machitidwe a hypoglycemic. Hypoglycemia yomwe imayamba mwa odwala imatha kukhala yotalikirapo, mwanjira zotere, chithandizo choyenera chofunikira ndikofunikira.

Kuwongolera kuchuluka kwa glucose m'magazi omwe amalandila ma hypoglycemic othandizira amatha kufooka pazinthu zotsatirazi: kutentha thupi, kuvulala, matenda opatsirana kapena kuchitapo opaleshoni. Zikatero, pangafunike kusiya mankhwala omwe ali ndi Diabeteson MV ndikupereka mankhwala a insulin.

Mphamvu ya Diabeteson MB (komanso mankhwala ena amkamwa hypoglycemic) mwa odwala ena amayamba kuchepa pakapita nthawi yayitali. Izi zitha kukhala chifukwa cha kuchuluka kwa matenda ashuga kapena kuchepa koyankha kwa mankhwalawa. Vutoli limadziwika kuti kukana kwachiwiri kwa mankhwala osokoneza bongo, omwe amafunika kusiyanitsidwa kuchokera koyambirira pomwe mankhwalawo amupangira koyamba ndipo samatulutsa zotsatira zomwe akuyembekezeka. Musanazindikire wodwala kuti ali ndi vuto lachiwiri la mankhwala, ndikofunikira kuti muwone kuyenera kwa kusankha kwa mankhwalawa ndikutsatira wodwala malinga ndi zakudya zomwe wapatsidwa.

Pa maziko azithandizo ndi Diabeteson MB, phenylbutazone ndi danazole osavomerezeka. Ndikofunikira kugwiritsa ntchito NSAID ina.

Poyerekeza ndi momwe chithandizo chikuyendera ndi Diabeteson MB, ndikofunikira kusiya kumwa mowa kapena mankhwala, omwe amaphatikizapo ethanol.

Ndikofunikira kudziwitsa wodwalayo ndi abale ake za chiwopsezo cha kukhala ndi hypoglycemia, Zizindikiro zake komanso zikhalidwe zomwe zikugwirizana ndi chitukuko chake. M'pofunikanso kufotokozera komwe kukana kwachiwiri ndi kwachiwiri kwa mankhwalawa kuli. Wodwalayo ayenera kudziwitsidwa za zoopsa zomwe zingachitike ndi chithandizo cha chithandizo chomwe akufuna, ndipo ndikofunikanso kumuuza zamtundu wina wamankhwala. Wodwala amafunika kufotokoza bwino kufunika kwa kudya mosasintha, kufunika kochita masewera olimbitsa thupi pafupipafupi komanso kuwunika mayendedwe a magazi ndi mkodzo.

Kuyang'anira ma labotale

Ndikofunikira kudziwa pafupipafupi kuchuluka kwa glucose ndi glycosylated hemoglobin m'magazi, zomwe zimakhala mumkodzo.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Odwala ayenera kudziwa zizindikiro za hypoglycemia ndipo ayenera kugwiritsa ntchito mosamala mukamayendetsa kapena kugwira ntchito yofunika kuthana ndi psychomotor.

Mankhwala osokoneza bongo:

Zizindikiro: hypoglycemia, woopsa - pamodzi ndi chikomokere, kukomoka ndi matenda ena am'mitsempha.

Chithandizo: Zizindikiro zolimbitsa thupi za hypoglycemia zimakonzedwa ndikumwa chakudya, kusankha mlingo komanso / kapena kusintha kadyedwe. Kuwunikira mosamala mkhalidwe wa wodwalayo kuyenera kupitilizidwa mpaka adokotala akutsimikiza kuti thanzi la wodwalayo silili pangozi. M'mikhalidwe yovuta kwambiri, chithandizo chamankhwala chodzidzimutsa ndikugonekedwa kuchipatala ndikofunikira.

Ngati hypoglycemic coma ikukayikiridwa kapena kupezeka, wodwalayo amapaka jekeseni 50 ml ya njira yothetsera ya dextrose (glucose) 40% iv. Kenako, njira yovomerezeka ya dextrose (glucose) ya 5% imayendetsedwa kudzera m'mitsempha kuti magazi azikhala ndi magazi okwanira. Kuwunikira mosamala kuyenera kuchitika osachepera maola 48. M'tsogolomo, kutengera mkhalidwe wa wodwalayo, funso la kufunikira kowunikira ntchito zofunikira za wodwalayo liyenera kulingaliridwa.

Odwala omwe ali ndi matenda a chiwindi, kuchuluka kwa plasma kwa gliclazide kungachedwe. Kutsegula m'mimba nthawi zambiri sikuchitika kwa odwala oterewa chifukwa cholumikizidwa m'mapuloteni a plasma.

Kugwirizana kwa Diabeteson MV ndi mankhwala ena.

Mankhwala osokoneza bongo omwe amakulitsa zotsatira za Diabeteson MB

Kugwiritsa ntchito nthawi imodzi ya Diabeteson MB yokhala ndi miconazole (yogwiritsidwa ntchito mwadongosolo) kumathandizira kukula kwa hypoglycemia mpaka kukomoka.

Kuphatikiza sikofunikira

Phenylbutazone (wogwiritsa ntchito mwa zonse) amalimbikitsa mphamvu ya hypoglycemic ya zotumphukira za sulfonylurea, monga imasinthitsa zomangira zawo ndi mapuloteni a plasma ndipo / kapena amachedwetsa kutulutsa kwawo mthupi.

Kugwiritsa ntchito pamodzi kwa Diabeteson MB, Mowa ndi ethanol wokhala ndi mankhwala kumawonjezera hypoglycemia, kuletsa zovuta zomwe zimachitika, ndipo zimathandizira kukulitsa kukomoka kwa hypoglycemic.

Njira zopewera kusamala

Kugwiritsa ntchito pamodzi kwa beta-blockers kumavala zizindikiro zina za hypoglycemia, monga palpitations ndi tachycardia. Ambiri osasankha beta-blockers amawonjezera pafupipafupi komanso azovuta a hypoglycemia.

Fluconazole imachulukitsa nthawi ya T1 / 2 sulfonylureas komanso imawonjezera chiopsezo cha hypoglycemia.

Kugwiritsira ntchito nthawi yomweyo kwa ACE inhibitors (Captopril, enalapril) kungakulitse kuchuluka kwa hypoglycemic ya zotumphukira za sulfonylurea (malinga ndi lingaliro limodzi, kulolera kwa glucose kumatheka bwino chifukwa chakuchepa kwa insulini). Hypoglycemic zochita zimakhala zosowa.

Mankhwala omwe amachepetsa mphamvu ya Diabeteson MV

Kuphatikiza sikofunikira

Pogwiritsa ntchito munthawi yomweyo ndi danazol, kuchepa kwa mphamvu ya Diabeteson MB ndikotheka.

Njira zopewera kusamala

Kugwiritsa ntchito kwa Diabeteson MB ndi chlorpromazine mu Mlingo wambiri (zoposa 100 mg / tsiku) kungayambitse kuchuluka kwa shuga wamagazi chifukwa chakuchepa kwa insulin katulutsidwe.

Pogwiritsa ntchito munthawi yomweyo GCS (yogwiritsidwa ntchito mwa makina, yakunja ndi yakomweko) ndi ma tetracosactides, kuchuluka kwa glucose kumachulukanso ndikuthekera kwa ketoacidosis (kuchepa kwa kulolera kwa glucose mothandizidwa ndi GCS).

Pogwiritsa ntchito nthawi yomweyo ya Diabeteson MB yokhala ndi progestogens, zovuta za matenda a shuga zomwe zimayambitsa matenda ambiri zimayenera kukumbukiridwa.

Mukamagwiritsidwa ntchito palimodzi, 2-adrenoreceptor zolimbikitsa (zogwiritsa ntchito mwadongosolo) - ritodrin, salbutamol, terbutaline imakulitsa shuga m'magazi (kudziyang'anira nokha kuchuluka kwa glucose kuyenera kuperekedwa, ngati kuli kofunikira, kusintha kwa odwala kupita ku insulin kungakhale kofunikira).

Ngati ndi kotheka, kugwiritsa ntchito mitunduyi pamwambapa kuyenera kuwongolera kuchuluka kwa shuga m'magazi. Pangakhale kophatikizira kusintha mtundu wa Diabeteson MB onse munthawi yophatikiza mankhwala atasiya kumwa mankhwala ena.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi osinthidwa amasinthidwe.

Mapangidwe piritsi limodzi:

Zogwira ntchito: Gliclazide - 60.0 mg.
Omwe amathandizira: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cP. 160.0 mg, magnesium stearate 1.6 mg, silicon dioxide colloidal anhydrous 5.04 mg.

Mankhwala

Gliclazide ndi sulfonylurea yotumphukira, mankhwala amkamwa a hypoglycemic omwe amasiyana ndi mankhwala omwewo mwa kukhalapo kwa mphete ya heterocyclic ya N yokhala ndi chomangira cha endocyclic.

Glyclazide amachepetsa shuga m'magazi ndikulimbikitsa kubisala kwa insulini mwa maselo a beta a isanger a Langerhans. Kuwonjezeka kwa kuchuluka kwa postprandial insulin ndi C-peptide kumapitirira pambuyo pa zaka 2 za mankhwala.

Kuphatikiza pa momwe zimapangidwira kagayidwe kazakudya, gliclazide imakhala ndi mphamvu ya m'mitsempha.

Kukhudzika kwa mtima

Glyclazide amachepetsa chiopsezo cha mtsempha wamagazi ochepa kuchuluka kwa minofu plasminogen activator.

Zogulitsa

Pambuyo pakukonzekera pakamwa, gliclazide imangodzaza. Kuchulukana kwa gliclazide m'madzi am'magazi kumawonjezeka pang'onopang'ono m'maola asanu ndi limodzi oyamba, gawo lamapulogalamu limasungidwa kuyambira maola 6 mpaka 12.

Kusintha kwamunthu aliyense ndikotsika. Kudya sikumakhudza kuchuluka kapena kuchuluka kwa mayamwa a gliclazide.

Kupenda

Gliclazide imapangidwa makamaka mu chiwindi. Palibe metabolites yogwira mu plasma.

Glyclazide imakumbidwa makamaka ndi impso: chimbudzi chimachitika mwa ma metabolites, osakwana 1% amachotsedwa ndi impso osasinthika. Hafu ya moyo wa gliclazide imakhala pafupifupi maola 12 mpaka 20.

Zizindikiro zogwiritsidwa ntchito

Mankhwala a Diabeteson MV 60 mg ndi mankhwala kwa odwala azaka zopitilira 18 kuti athandizidwe motere:

Type 2 shuga mellitus osakwanira mutha kudya mankhwala, zolimbitsa thupi ndi kuchepa thupi.
Kupewa mavuto obwera chifukwa cha matenda a shuga: kuchepetsa chiopsezo cha maselo am'mimba (nephropathy, retinopathy) ndi zovuta zina (myocardial infarction, stroke) mwa odwala omwe ali ndi matenda a shuga a 2 mellitus kwambiri.

Mlingo ndi makonzedwe

Mankhwalawa amaperekedwa kwa akulu okha!

Mlingo woyenera uyenera kumwa pakamwa, nthawi 1 makamaka pakudya m'mawa. Mlingo wa tsiku ndi tsiku ukhoza kukhala 30 -120 mg (mapiritsi 1/2) mu gawo limodzi. Ndi bwino kumeza piritsi kapena theka la piritsi yonse popanda kutafuna kapena kuphwanya.

Ngati mwaphonya mtundu umodzi kapena zingapo za mankhwalawo, simungathe kutenga mlingo wambiri muyezo lotsatira, mlingo womwe mwasowa uyenera kumwa tsiku lotsatira.

Monga mankhwala ena a hypoglycemic, muyeso wa mankhwalawa mu mankhwalawa umayenera kusankhidwa malinga ndi kuchuluka kwa shuga wamagazi ndi HbAlc.

Mlingo woyambirira

Pulogalamu yoyambirira yoyambira (kuphatikizapo odwala okalamba 30 mg patsiku (piritsi 1/2).

Pofuna kuwongolera mokwanira, mankhwalawa amatha kugwiritsidwa ntchito pokonzanso mankhwala. Ndi osakwanira glycemic control, tsiku ndi tsiku mlingo wa mankhwalawa ukhoza kuchuluka mpaka 60, 90 kapena 120 mg.

Kukula kwa mankhwalawa ndikotheka osati kale kuposa mwezi umodzi wotsatira wa mankhwala osokoneza bongo omwe adalandira kale. Chosiyana ndi odwala omwe magazi a glucose awo sanachepe pambuyo pa milungu iwiri. Zikatero, mlingo utha kuwonjezeka patatha masabata awiri chiyambireni kukhazikitsa.

Pazipita tsiku lililonse la mankhwalawa ndi 120 mg.

Piritsi limodzi la mankhwala a Diabeteson® MV mapiritsi osinthidwa amasintha 60 mg ndi ofanana ndi mapiritsi awiri a mapiritsi a Diabeteson ® MV omwe amasulidwa 30 mg Kukhalapo kwa notch pamapiritsi a 60 mg kumakupatsani mwayi wogawa piritsi ndi kumwa tsiku lililonse 30 mg (1/2 piritsi 60 mg), ndipo ngati pakufunika, 90 mg (1 ndi 1/2 piritsi 60 mg).

Kusintha kuchokera kwa wothandizira wina wa hypoglycemic kupita ku Diabeteson MV 60 mg

Diabeteson ®: Mapiritsi a MV omwe atulutsidwa mosintha 60 mg angagwiritsidwe ntchito m'malo mwa mankhwala ena a hypoglycemic pakuchita pakamwa. Mukasamutsa odwala omwe amalandila mankhwala ena a hypoglycemic pamlomo wofikira ku Diabeteson® MV, mlingo wawo ndi theka la moyo uyenera kukumbukiridwa. Monga lamulo, nthawi yosintha siyofunikira. Mlingo woyambirira uyenera kukhala 30 mg ndipo kenaka umatenthedwa malinga ndi kuchuluka kwa shuga m'magazi. Diabeteson ® MV ikadzalowedwa m'malo ena ndi sulfonylurea ndi theka-moyo kuti mupewe hypoglycemia yoyambitsidwa ndi kuwonjezereka kwa othandizira awiri a hypoglycemic, mutha kusiya kuwatenga kwa masiku angapo.

Mlingo woyambirira wa mankhwalawa Diabeteson® MV ulinso 30 mg (1/2 piritsi 60 mg) ndipo, ngati kuli kofunikira, utha kuwonjezereka mtsogolo, monga tafotokozera pamwambapa.

Odwala omwe Ali pachiwopsezo cha Hypoglycemia

Odwala omwe ali pachiwopsezo cha kukhala ndi hypoglycemia (zakudya zosakwanira kapena zopanda thanzi, zovuta za endocrine zowonongeka: pituitary adrenal insufficiency, hypothyroidism, kusiya kwa glucocorticosteroids (GCS) atagwiritsidwa ntchito kwa nthawi yayitali komanso / kapena makonzedwe akulu. machitidwe - mtima matenda a mtima, kwambiri atherosclerosis ya carotid mitsempha, wamba atherosulinosis, tikulimbikitsidwa kugwiritsa ntchito osachepera 30 mg ya mankhwala Diabeteson® MV.

Kupewa matenda ashuga

Kuti mukwaniritse kuyang'anira kwa glycemic kwambiri, mutha kuwonjezera pang'onopang'ono mlingo wa Diabeteson® MV kufika pa 120 mg / tsiku, kuwonjezera pa zakudya ndi masewera olimbitsa thupi, kuti mupeze gawo la HbAlc. Kumbukirani kuopsa kokhala ndi hypoglycemia. Kuphatikiza apo, mankhwala ena a hypoglycemic, mwachitsanzo, metformin, alpha-glucosidase inhibitor, a hyazolidinedione derivative kapena insulin, amatha kuwonjezeredwa ku mankhwala.

Kugwiritsa ntchito mankhwalawa pa mimba komanso mkaka wa m`mawere

Palibe chidziwitso chakugwiritsa ntchito mapiritsi a Diabeteson MV panthawi yomwe mayi akakhala ndi pakati. Ngakhale kuti kafukufuku wazinyama sanatsimikizire teratogenic ndi mphamvu ya mwana wosabadwayo, mankhwalawa amalembedwa pochiritsa amayi apakati. Ngati matenda a shuga apezeka mwa azimayi panthawi yoyembekezera, wodwalayo amasankhidwa njira ina yomwe singakhale yangozi kwa mwana wosabadwayo. Potere, adotolo amayang'anira zonse zomwe zimachitika mkazi.

Ngati mayi amathandizidwa ndi Diabeteson MV, ndipo mimba yayamba kale, chithandizo chikuyenera kuyimitsidwa nthawi yomweyo ndikuyang'ana kwa dokotala, onetsetsani kuti mwalandira za mankhwalawo.

Kugwiritsa ntchito mankhwalawa kwa hypoglycemic panthawi yoyamwitsa kumaletsedwa, chifukwa magawo omwe amagwira ntchito amatha kulowa mkaka, kenako ndikulowa m'thupi la mwana. Ngati ndi kotheka, mankhwalawa ayenera kusiyidwa.

Hypoglycemia

Monga mankhwala ena a gulu la sulfonylurea, mankhwalawa Diabeteson MV angayambitse hypoglycemia ngati vuto la umphawi makamaka ngati kudya kulibe. Zizindikiro zotheka za hypoglycemia: kupweteka mutu, kugona kwambiri, nseru, kusanza, kutopa kwambiri, kusokonezeka, kukwiya, kuchepetsa chidwi, kuchepetsedwa kuyankha, kukhumudwa, kusokonezeka, masomphenya komanso kuyankhula, aphasia, kugwedezeka, kuperewera, kulephera kudziletsa. , kumva kuti ndi wopanda thandizo, kuzindikira kwa vuto, chizungulire, kufooka, kupsinjika, bradycardia, delirium, kupuma kosasunthika, kugona, kugona chikumbumtima ndi kuthekera kwa chikomokere, mpaka pakufa.

Kuchitikanso kwa Andrenergic kungatchulidwenso: kutuluka thukuta, "povutirapo" khungu, nkhawa, tachycardia, kuthamanga kwa magazi, palpitations, arrhythmia, ndi angina pectoris.

Monga lamulo, Zizindikiro za hypoglycemia zimayimitsidwa pomwa chakudya (shuga).

Kutenga zotsekemera sikugwira ntchito. Poyerekeza ndi zam'mbuyo za zinthu zina zochokera ku sulfonylurea, zotulukanso za hypoglycemia zidadziwika pambuyo pakupuma bwino.

Mu hypoglycemia yayitali kapena yayitali, chithandizo chamankhwala mwadzidzidzi chafotokozedwa, mwina ndi kuchipatala, ngakhale zitakhala kuti pali zotsatira za kumwa chakudya.

Zotsatira zina zoyipa

Kuchokera m'mimba thirakiti: kupweteka kwam'mimba, nseru, kusanza, kutsegula m'mimba, kudzimbidwa. Kumwa mankhwalawa mukamadya kadzutsa kumapewa Zizindikiro kapena kuwachepetsa.
Pa khungu ndi subcutaneous minofu: zotupa. kuyabwa urticaria, edema ya Quincke, erythema, zotupa za maculopapullous, zotupa zambiri (monga Stevens-Jones syndrome ndi poermal necrolysis yoopsa).
Hematopoietic ziwalo ndi dongosolo la lymphatic: matenda a hematological (anemia, leukopenia, thrombocytopenia, granulocytopenia) ndi osowa.
Kumbali ya chiwindi ndi biliary thirakiti: ntchito yowonjezera ya "chiwindi" michere (aspartate aminotransferase (ACT), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (yachilendo milandu). Ngati cholestatic jaundice ichitika, mankhwalawa ayenera kusiyidwa.
Kuchokera kumbali ya gawo la masomphenyawo: kusokonezeka kowoneka kwakanthawi kumatha kuchitika chifukwa cha kusintha kwa kuchuluka kwa shuga m'magazi, makamaka kumayambiriro kwa chithandizo.

Kuchita ndi mankhwala ena

Mankhwala a Diabeteson MV 60 mg sayenera kumwedwa nthawi yomweyo ndi miconazole, chifukwa kuyanjana kumeneku kumapangitsa kuchuluka kwa hypoglycemic, komwe kungayambitse kukula kwa hypoglycemic coma.

Mankhwalawa amatha kuchepetsa othandizira kulera pakamwa, chifukwa chake, odwala omwe amagwiritsa ntchito njira yotetezerayi ayenera kuchenjezedwa za chiwopsezo cha kutenga pakati kosakonzekera.

Mankhwala osavomerezeka kuti aphatikizidwe ndi mankhwalawa omwe amaphatikizapo ethanol, chifukwa izi zingapangitse kuwonjezeka kwa zotsatira za hypoglycemic komanso kukulitsa zovuta zama chiwindi.

Mankhwala Okhala Pamalo a Pharmacy

Mankhwala otsatirawa ndi fanizo la Diabeteson MV:

Mapiritsi a Glidiab
Glidiab MV,
Diabefarm MV,
Gliclazide MV.

Asanalowe m'malo mwake ndi analog, wodwalayo ayenera kuonana ndi endocrinologist.

Mtengo wapakati wa mankhwalawa a Diabeteson MV 60 mg ku pharmacies aku Moscow ndi ma ruble 150-180 pa paketi (mapiritsi 30).

Fomu ya Mlingo:

Zopangidwa:
Piritsi limodzi lili:
Chithandizo: gliclazide - 60.0 mg.
Othandizira: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cp 160.0 mg, magnesium stearate 1.6 mg, anhydrous colloidal silicon dioxide 5.04 mg.

Kufotokozera
Zoyera, biconvex, mapiritsi ozungulira omwe ali ndi notch ndipo amalemba "DIA" "60" mbali zonse ziwiri.

Gulu la Pharmacotherapeutic:

Code ya ATX: A10BB09

ZOCHULUKA ZA PHARMACOLOGICAL

Mankhwala
Glyclazide ndi sulfonylurea yotumphukira, mankhwala amkamwa a hypoglycemic omwe amasiyana ndi mankhwala omwewo mwa kukhalapo kwa mphete ya N ya heterocyclic yokhala ndi chomangira cha endocyclic.
Gliclazide imachepetsa kuchuluka kwa shuga m'magazi, kumapangitsa kuti insulin isungidwe ndi β-maselo a masheya a Langerhans. Kuwonjezeka kwa ndende ya postprandial insulin ndi C-peptide kumapitirira pambuyo pa zaka 2 za mankhwala.
Kuphatikiza pa momwe zimapangidwira kagayidwe kazakudya, gliclazide imakhala ndi mphamvu ya m'mitsempha.

Zokhudza insulin katulutsidwe
Mtundu wachiwiri wa matenda a shuga, mankhwalawa amabwezeretsa chiyambi champhamvu cha insulin chifukwa cha kuchuluka kwa glucose ndikuwonjezera gawo lachiwiri la insulin secretion. Kuwonjezeka kwakukulu kwa insulin katulutsidwe kumawonedwa poyankha kukondoweza chifukwa cha kudya kapena kutsika kwa shuga.

Kukhudzika kwa mtima
Glyclazide amachepetsa chiopsezo cha chotupa chama magazi₂), komanso kubwezeretsa ntchito ya fibrinolytic ya mtima endothelium ndikuwonjezera ntchito ya minofu plasminogen activator.
Kuwongolera kwambiri kwa glycemic potsatira kugwiritsidwa ntchito kwa Diabeteson ® MV (HbA1c Njira yakuyendetsa glycemic kwambiri ikuphatikiza kukhazikitsidwa kwa mankhwala a Diabeteson ® MV ndikuwonjezera mlingo wake motsutsana ndi maziko a (kapena m'malo mwake) mankhwala othandizira asanawonjezerenso mankhwala ena a hypoglycemic (mwachitsanzo, metformin, alpha-glucosidase inhibitor thiazolidinedione derivative kapena insulini.) Pakati pa tsiku Mlingo wa mankhwala osokoneza bongo a diabeteson ® MV odwala omwe ali m'gulu lolamulira anali 103 mg, omwe amakhala ambiri tsiku lililonse mlingo anali 120 mg.
Poyerekeza ndi kagwiritsidwe ntchito ka mankhwala a Diabeteson ® MV pagulu lowongolera glycemic (gulu lotsata zaka 4.8, pafupifupi HbA1c 6.5%) poyerekeza ndi gulu lolamulira wamba (pafupifupi HbA1c 7.3%), kuchepa kwakukulu kwa 10% kukuwonetsedwa chiopsezo cha kuphatikiza pafupipafupi kwa macro- ndi microvascular complication
Ubwino unakwaniritsidwa pakuchepetsa kwambiri chiopsezo chaching'ono: zovuta zazikulu za microvascular ndi 14%, kuyambika ndi kupitilira kwa nephropathy ndi 21%, kupezeka kwa microalbuminuria ndi 9%, macroalbuminuria ndi 30% komanso kukula kwa aimpso ndi 11%.
Ubwino wowongolera glycemic kwambiri mukamamwa Diabeteson ® MV sizinadalire zabwino zomwe zimapezeka ndi antihypertensive therapy.

Pharmacokinetics

Zogulitsa
Pambuyo pakukonzekera pakamwa, gliclazide imangodzaza. Kuchulukana kwa gliclazide m'madzi am'magazi kumawonjezeka pang'onopang'ono m'maola asanu ndi limodzi oyamba, gawo lamapulogalamu limasungidwa kuyambira maola 6 mpaka 12. Kusintha kwamunthu aliyense ndi kotsika.
Kudya sikukhudza kuchuluka kapena kufalikira kwa gliclazide.

Kugawa
Pafupifupi 95% ya glycazide imamangiriza mapuloteni a plasma. Kuchuluka kwa magawo ndi pafupifupi malita 30.Kumwa mankhwala a diabeteson ® MV muyezo wa 60 mg kamodzi patsiku kumathandizira kuti azisungika gliclazide yogwira plasma kwa maola opitilira 24.

Kupenda
Gliclazide imapangidwa makamaka mu chiwindi. Palibe metabolites yogwira mu plasma.

Kuswana
Glyclazide imakumbidwa makamaka ndi impso: chimbudzi chimachitika mwa ma metabolites, osakwana 1% omwe impso sinasinthidwe. Hafu ya moyo wa gliclazide ndi pafupifupi maola 12 mpaka 20.

Chotsogola
Ubale pakati pa kumwa womwe watengedwa (mpaka 120 mg) ndi dera lomwe pansi pa pharmacokinetic pamapindikira "nthawi -" ndi lofanana.

Anthu apadera
Anthu okalamba
Okalamba, palibe kusintha kwakukulu pama paracminetic paraceter.

MALO OGWIRITSITSA NTCHITO Ntchito

Type 2 shuga mellitus osakwanira mutha kudya mankhwala, zolimbitsa thupi ndi kuchepa thupi.
Kupewa mavuto obwera chifukwa cha matenda a shuga: kuchepetsa chiopsezo cha maselo am'mimba (nephropathy, retinopathy) ndi zovuta zina (myocardial infarction, stroke) mwa odwala omwe ali ndi matenda a shuga a 2 mellitus kwambiri.

Hypersensitivity to gliclazide, zotumphukira zina za sulfonylurea, sulfonamides kapena zotulutsa zomwe ndi mbali ya mankhwala,
mtundu 1 shuga
matenda ashuga ketoacidosis, matenda a shuga, matenda ashuga,
kwambiri aimpso kapena kwa chiwindi (mu izi, tikulimbikitsidwa kugwiritsa ntchito insulin),
kutenga miconazole (onani gawo "Kuyanjana ndi mankhwala ena"),
mimba ndi mkaka wa m`mawere (onani gawo "Nthawi ya pakati ndi nthawi ya mkaka wa m'mawere"),
wazaka 18.

Chifukwa chakuti kukonzekera kumakhala ndi lactose, Diabeteson MV siyikulimbikitsidwa kwa odwala omwe amabadwa ndi vuto lactose tsankho, galactosemia, shuga-galactose malabsorption.
Simalimbikitsidwa kugwiritsidwa ntchito limodzi ndi phenylbutazone kapena danazole (onani gawo "Kuyanjana ndi mankhwala ena").

Ndi chisamaliro
Okalamba, osakhazikika komanso / kapena osagwiritsa ntchito zakudya, kuchepa kwa glucose-6-phosphate dehydrogenase, matenda owopsa a mtima dongosolo, hypothyroidism, adrenal kapena pituitary insufficiency, aimpso ndi / kapena kulephera kwa chiwindi, chithandizo chotalikilapo ndi glucocorticosteroids (GCS), uchidakwa.

KULAMBIRA KOPANDA CHINENERO

Mimba
Palibe zinachitikira ndi gliclazide pa nthawi yapakati. Zomwe zimagwiritsidwa ntchito pazinthu zina za sulfonylurea panthawi yapakati ndizochepa.
Mu maphunziro a nyama yothandizira, teratogenic zotsatira za gliclazide sizinadziwikebe.
Kuchepetsa chiopsezo cha kubadwa mwatsopano, kuwongolera koyenera (chithandizo choyenera) cha matenda osokoneza bongo ndikofunikira. Mankhwala a Oral hypoglycemic pa nthawi yoyembekezera sagwiritsidwa ntchito.
Insulin ndi mankhwala osankhidwa ochizira matenda a shuga mwa amayi apakati.
Ndikulimbikitsidwa kuti m'malo mankhwalawa pakhale kumwa kwa mankhwala a hypoglycemic ndi insulin mankhwala onse omwe ali ndi pakati, komanso ngati kutenga pakati kumachitika pakumwa mankhwalawo.

Kuyamwitsa
Poganizira kusowa kwa chidziwitso cha kudya kwa gliclazide mkaka wa m'mawere ndi chiopsezo chotenga neonatal hypoglycemia, kuyamwitsa kumayesedwa panthawi ya mankhwala.

ULEMEKEZO NDI KULAMULIRA

DZIKO LAPANSI NDI GALITSE MOPANDA KUKULA KWA ATSOGOLO.

Mlingo woyenera uyenera kumwedwa pakumwa kamodzi, patsiku, makamaka pakudya kwam'mawa.
Mlingo wa tsiku ndi tsiku ukhoza kukhala 30-120 mg (1 /₂ Mapiritsi a 2) mu gawo limodzi.
Ndi bwino kumeza piritsi kapena theka la piritsi yonse popanda kutafuna kapena kuphwanya.
Ngati mwaphonya mtundu umodzi kapena zingapo za mankhwalawo, simungathe kutenga mlingo wambiri muyezo lotsatira, mlingo womwe mwasowa uyenera kumwa tsiku lotsatira.
Monga mankhwala ena a hypoglycemic, muyeso wa mankhwalawa mu mankhwalawa umayenera kusankhidwa payekha, kutengera kuchuluka kwa shuga ndi HbA1c.

Mlingo woyambira
Mlingo woyambitsidwa woyamba (kuphatikiza odwala okalamba, ≥ zaka 65) ndi 30 mg patsiku (1 /₂ mapiritsi).
Pofuna kuwongolera mokwanira, mankhwalawa amatha kugwiritsidwa ntchito pokonzanso mankhwala. Ndi osakwanira glycemic control, tsiku ndi tsiku mlingo wa mankhwalawa ukhoza kuchuluka mpaka 60, 90 kapena 120 mg.
Kukula kwa mankhwalawa ndikotheka osati kale kuposa mwezi umodzi wotsatira wa mankhwala osokoneza bongo omwe adalandira kale. Chosiyana ndi odwala omwe magazi a glucose awo sanachepe pambuyo pa milungu iwiri. Zikatero, mlingo utha kuwonjezeka patatha masabata awiri chiyambireni kukhazikitsa.
Pazipita tsiku lililonse la mankhwalawa ndi 120 mg.
Piritsi limodzi la mankhwala a Diabeteson ® MV mapiritsi osinthika amasintha 60 mg ndi ofanana ndi mapiritsi awiri a Diabeteson ® MV mapiritsi osinthika 30 mg Kupezeka kwa notch pamapiritsi a 60 mg kumakupatsani mwayi wogawa piritsi ndi kumwa tsiku lililonse 30 mg (1/1)₂ mapiritsi 60 mg), ndipo ngati pakufunika 90 mg (1 ndi 1/1 /₂ Mapiritsi a 60 mg).

Kusintha kwa kumwa mankhwala a diabeteson ® mapiritsi a 80 mg a mankhwala a diabeteson ® MV mapiritsi osinthika 60 mg Piritsi limodzi la mankhwala a Diabeteson ® 80 mg akhoza kutha 1/1₂ Mapiritsi okhala ndi shuga osinthidwa Diabeteson ® MV 60 mg. Mukasamutsa odwala kuchokera ku Diabeteson ® 80 mg kupita ku Diabeteson ® MV, kuyang'anira mosamala glycemic ndikulimbikitsidwa.

Kusintha pa kutenga wina mankhwala a hypoglycemic kupita ku mapiritsi a Diabeteson ® MV ndikusintha kosintha kwa 60 mg
Mankhwala a Diabeteson ® MV mapiritsi okhala ndi masinthidwe osinthika a 60 mg angagwiritsidwe ntchito m'malo mwa mankhwala ena a hypoglycemic pakumwa pakamwa. Mukasamutsa odwala omwe amalandila mankhwala ena a hypoglycemic pakumwa kwa pakamwa kwa Diabeteson ® MV, mlingo wawo ndi theka la moyo ayenera kukumbukiridwa. Monga lamulo, nthawi yosintha siyofunikira. Mlingo woyambirira uyenera kukhala 30 mg ndipo kenaka umatenthedwa malinga ndi kuchuluka kwa shuga m'magazi.
Diabeteson ® MV ikadzalowedwa ndi zotumphukira za sulfonylurea ndi moyo wautali wa moyo kupewa hypoglycemia yoyambitsidwa ndi kuwonjezereka kwa othandizira awiri a hypoglycemic, mutha kusiya kuwatenga kwa masiku angapo. Mlingo woyambirira wa mankhwala a diabeteson ® MV alinso 30 mg (1 /₂ mapiritsi 60 mg) ndipo, ngati kuli kotheka, akhoza kuwonjezereka m'tsogolo, monga tafotokozera pamwambapa.

Kuphatikizika kwa ntchito ndi mankhwala ena a hypoglycemic
Diabeteson ® MV ikhoza kugwiritsidwa ntchito limodzi ndi biguanidins, alpha-glucosidase inhibitors kapena insulin. Ndi osakwanira pakuwongolera glycemic, mankhwala owonjezera a insulin ayenera kuyikidwa ndi kuyang'aniridwa mosamala kuchipatala.

Odwala okalamba
Kusintha kwa Mlingo kwa odwala okulirapo zaka 65 sikofunikira.

Odwala omwe ali ndi vuto la impso
Zotsatira za kafukufuku wazachipatala zawonetsa kuti kusintha kwa mlingo kwa odwala omwe ali ndi kufatsa pang'ono komanso aimpso sikufunika. Pafupifupi kuyang'anira kuchipatala ndikulimbikitsidwa.

Odwala omwe Ali pachiwopsezo cha Hypoglycemia
Odwala omwe ali pachiwopsezo cha kukhala ndi hypoglycemia (chakudya chokwanira kapena chosakwanira, zovuta za endocrine zowonongeka - kuchepa kwa thupi ndi vuto la adrenal, hypothyroidism, kuthetsedwa kwa glucocorticosteroids (GCS) atagwiritsidwa ntchito kwa nthawi yayitali komanso / kapena makonzedwe akulu. mtima dongosolo - kwambiri mtima matenda, atherosclerosis ya carotid mitsempha, wamba atherosulinosis, tikulimbikitsidwa kugwiritsa ntchito osachepera 30 mg wa prep Ata Diabeton ® MV.

Kupewa matenda ashuga
Kuti mukwaniritse kuyang'anira kwambiri glycemic, mutha kuwonjezera pang'onopang'ono mlingo wa mankhwalawa Diabeteson ® MV mpaka 120 mg / tsiku kuwonjezera pa zakudya ndi masewera olimbitsa thupi kuti mukwaniritse chandamale cha HbA1c. Kumbukirani kuopsa kokhala ndi hypoglycemia. Kuphatikiza apo, mankhwala ena a hypoglycemic, mwachitsanzo, metformin, alpha-glucosidase inhibitor, thiazolidinedione derivative kapena insulin, amatha kuwonjezeredwa ku mankhwala.

Ana ndi achinyamata ochepera zaka 18.
Zambiri pakugwiritsa ntchito mankhwalawa kwa ana ndi achinyamata osakwana zaka 18 sizipezeka.

ZOTHANDIZA ZONSE
Poganizira momwe zinachitikira ndi gliclazide, muyenera kukumbukira za momwe mungapangire zotsatirazi.

Hypoglycemia
Monga mankhwala ena a gulu la sulfonylurea, mankhwalawa Diabeteson ® MV angayambitse matenda a hypoglycemia chifukwa cha zakudya zosafunikira makamaka makamaka ngati zakudya zikusowa. Zizindikiro zotheka za hypoglycemia: kupweteka mutu, kugona kwambiri, nseru, kusanza, kutopa kwambiri, kusokonezeka, kukwiya, kuchepetsa chidwi, kuchepetsedwa kuyankha, kukhumudwa, kusokonezeka, masomphenya komanso kuyankhula, aphasia, kugwedezeka, kuperewera, kulephera kudziletsa. , kumva kuti ndi wopanda thandizo, kuzindikira kwa vuto, chizungulire, kufooka, kupsinjika, bradycardia, delirium, kupuma kosasunthika, kugona, kugona chikumbumtima ndi kuthekera kwa chikomokere, mpaka pakufa.
Kuchitikanso kwa Andrenergic kungatchulidwenso: kutuluka thukuta, "povutirapo" khungu, nkhawa, tachycardia, kuthamanga kwa magazi, palpitations, arrhythmia, ndi angina pectoris.

Monga lamulo, Zizindikiro za hypoglycemia zimayimitsidwa pomwa chakudya (shuga). Kutenga zotsekemera sikugwira ntchito. Poyerekeza ndi zam'mbuyo za zinthu zina zochokera ku sulfonylurea, zotulukanso za hypoglycemia zidadziwika pambuyo pakupuma bwino.

Mu hypoglycemia yayitali kapena yayitali, chithandizo chamankhwala mwadzidzidzi chafotokozedwa, mwina ndi kuchipatala, ngakhale zitakhala kuti pali zotsatira za kumwa chakudya.

Zotsatira zina zoyipa

Kuchokera m'mimba: kupweteka kwam'mimba, nseru, kusanza, kutsegula m'mimba, kudzimbidwa. Kumwa mankhwalawa mukamadya kadzutsa kumapewa Zizindikiro kapena kuwachepetsa.

Zotsatira zotsatirazi ndizochepa:

Pa khungu ndi subcutaneous minofu: zotupa, kuyabwa, urticaria, edema ya Quincke, erythema, maculopapular zidzolo, zochita zazambiri (monga Stevens-Jones syndrome ndi poermal necrolysis yoopsa).

Kuchokera ku ziwalo za hemopoietic ndi dongosolo la lymphatic: Matenda a hematological (anemia, leukopenia, thrombocytopenia, granulocytopenia) ndi osowa. Monga lamulo, zochitika izi zimatha kusintha ngati chithandizo chitha.

Pa mbali ya chiwindi ndi biliary thirakiti: kuchuluka kwa "chiwindi" michere (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (ena akutali). Ngati cholestatic jaundice ichitika, mankhwalawa ayenera kusiyidwa.

Izi nthawi zambiri zimatha kusintha ngati chithandizo chitha.

Kuchokera kumbali ya gawo la masomphenyawo: kusokonezeka kwakanthawi kochepa kumatha kuchitika chifukwa cha kusintha kwa kuchuluka kwa shuga wamagazi, makamaka kumayambiriro kwa chithandizo.

Zotsatira zoyipa zomwe zimachokera ku sulfonylurea: monga zina zotumphukira za sulfonylurea, zotsatirapo zoyipa zinaonedwa: erythrocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, matupi a vasculitis, hyponatremia. Panali kuwonjezeka kwa ntchito ya "chiwindi" michere, chiwindi ntchito (mwachitsanzo, ndikupanga cholestasis ndi jaundice) ndi hepatitis, mawonetseredwe amachepetsa patapita nthawi atasiya kukonzekera kwa sulfonylurea, koma nthawi zina zimapangitsa kuti chiwindi chisawonongeke.

Zotsatira zoyipa zomwe zimadziwika mu mayesero azachipatala
Mu kafukufuku wa ADVANCE, panali kusiyana pang'ono kawirikawiri pazovuta zazikulu zingapo pakati pamagulu awiriwa. Palibe zatsopano zachitetezo zomwe zalandilidwa. Odwala ochepa anali ndi hypoglycemia yayikulu, koma kuchuluka kwa hypoglycemia kunali kotsika. Zotsatira za hypoglycemia pagulu lolamulira la glycemic zinali zochuluka kuposa zomwe zinali pagulu lolamulira. Magawo ambiri a hypoglycemia omwe ali pagulu lolamulira glycemic amawonetsedwa motsutsana ndi maziko a insulin yothandizira.

CHONCHO
Ngati bongo wa sulfonylurea zotumphukira, hypoglycemia angayambe.
Ngati mukumva zizindikiro za hypoglycemia popanda nkhawa kapena minyewa, muyenera kuwonjezera kuchuluka kwa chakudya chamagulu ndi chakudya, kuchepetsa kuchuluka kwa mankhwalawo komanso / kapena kusintha kadyedwe. Kuyan'ana zamankhwala kwa wodwalayo kuyenera kupitiliza mpaka pakukhulupirira kuti palibe chomwe chingawononge thanzi lake. Mwina chitukuko cha matenda oopsa a hypoglycemic, limodzi ndi chikomokere, kukomoka kapena matenda ena amanjenje. Ngati zizindikiro zotere zikuwoneka, chithandizo chamankhwala chodzidzimutsa ndi kuchipatala mwachangu ndikofunikira.
Ngati muli ndi vuto la hypoglycemic coma kapena ngati akukayikira, wodwala amapaka jekeseni 50 ml ya yankho la 20-30% ya dextrose (glucose). Kenako, 10% dextrose solution imayendetsedwa moyenera kuti ikhalebe magazi osakanikirana pamwamba pa 1 g / L. Kuwunikira mosamala kuchuluka kwa shuga wamagazi ndikuwunika kwa wodwalayo kuyenera kuchitidwa kwa maola osachepera 48. Pambuyo pa nthawi yino, kutengera mtundu wa wodwalayo, adokotala amafunikira pakuwunika ntchito zina. Kutsegula m'mimba sikugwira ntchito chifukwa cha kutchulidwa kwa gliclazide kwa mapuloteni a plasma.

KUGWIRITSANA NDIPONSO ZITSANZO ZINA

1) Mankhwala osokoneza bongo komanso zinthu zomwe zimawonjezera chiopsezo cha hypoglycemia:
(kukulitsa mphamvu ya gliclazide)

Kuphatikiza kophatikizidwa
- Miconazole (ndi makonzedwe oyenera komanso mukamagwiritsa ntchito gel osakaniza pakamwa): imakweza mphamvu ya hypoglycemic ya gliclazide (hypoglycemia ikhoza kukhala mpaka kukomoka).

Osavomerezeka kuphatikiza
- Phenylbutazone (kachitidwe ka makonzedwe): imawonjezera mphamvu ya hypoglycemic ya zotumphukira za sulfonylurea (zimawachotsera kulumikizana ndi mapuloteni a plasma komanso / kapena kuchedwetsa kuchoka kwake mthupi.
Ndikofunika kugwiritsa ntchito mankhwala ena odana ndi kutupa. Ngati phenylbutazone ndiyofunikira, wodwalayo ayenera kuchenjezedwa za kufunika koyang'anira glycemic. Ngati ndi kotheka, mlingo wa mankhwalawa Diabeteson ® MV uyenera kusinthidwa pamene mukumwa phenylbutazone ndi pambuyo pake.
- Ethanoli : imawonjezera hypoglycemia, kuletsa zovuta zomwe zimachitika, zimathandizira kukulitsa kukomoka kwa hypoglycemic. Ndikofunikira kukana kumwa mankhwala, monga ethanol ndi mowa.

Njira zopewera
Glyclazide kuphatikiza mankhwala ena: othandizira ena a hypoglycemic (insulin, acarbose, metformin, thiazolidinidiones, dipeptidyl peptidase-4 inhibitors, GLP-1 agonists), ma beta-adrenergic othandizira, fluconazole, angiotensin-antiplatelet inhibitors, caprimentin-antiplatelet inhibitors₂-histamine receptors, monoamine oxidase inhibitors, sulfonamides, clarithromycin ndi mankhwala osokoneza bongo omwe amaletsa kutupa) amaphatikizidwa ndi kuwonjezeka kwa zotsatira za hypoglycemic komanso chiwopsezo cha hypoglycemia.

2) Mankhwala omwe amachulukitsa shuga m'magazi:
(kufooketsa mphamvu ya gliclazide)

- Danazole: ali ndi matenda ashuga. Ngati kumwa mankhwalawa ndikofunikira, wodwalayo akulangizidwa kuti azitsatira shuga wa magazi mosamala. Ngati ndi kotheka, molumikizana mankhwala, tikulimbikitsidwa kuti mlingo wa hypoglycemic wothandizila amasankhidwa onse munthawi ya danazol atachokapo.

Njira zopewera
- Chlorpromazine (antipsychotic) Mlingo wambiri (oposa 100 mg wa patsiku) umachulukitsa kuchuluka kwa shuga m'magazi, kuchepetsa kubisika kwa insulin.
Kuwongolera mosamala glycemic ndikulimbikitsidwa. Ngati ndi kotheka, molumikizana mankhwala, tikulimbikitsidwa kuti mlingo wa hypoglycemic wothandizila kusankhidwa, onse munthawi ya antipsychotic atachoka.
- GKS (zokhudza zonse ndi ntchito wamba: intraarticular, khungu, rectal management) ndi tetracosactide: kuonjezera kuchuluka kwa shuga ndi kuthekera kwa ketoacidosis (kuchepa kwa kulekerera kwa chakudya chambiri). Kuwongolera mosamala glycemic ndikulimbikitsidwa, makamaka kumayambiriro kwa chithandizo. Ngati kuli kofunikira kutenga mankhwala limodzi, kusintha kwa mlingo wa hypoglycemic wothandizila kungafunike panthawi yonse yoyang'anira GCS komanso atachokapo.
- Ritodrin, salbutamol, terbutaline (mtsempha wama mtsempha): beta-2 adrenergic agonists amalimbikitsa kuchuluka kwa shuga ndende.
Iyenera kuwunika makamaka pakufunika kodziletsa. Ngati ndi kotheka, tikulimbikitsidwa kusamutsa wodwala kupita ku insulin.

3) Kuphatikiza kuyenera kukumbukiridwa

- Anticoagulants (mwachitsanzo warfarin)
Zomwe zimachokera ku sulfonylureas zimatha kupititsa patsogolo zotsatira za ma anticoagulants pamene atengedwa limodzi. Kusintha kwa mankhwalawa kwa anticoagulant kungafunike.

MALANGIZO OTHANDIZA

Hypoglycemia
Mukamamwa mankhwala a sulfonylurea, kuphatikiza gliclazide, hypoglycemia imayamba, nthawi zina imakhala yovuta kwambiri komanso imatenga nthawi yayitali, imafuna kuchipatala komanso kuyamwa kwa njira ya dextrose masiku angapo (onani gawo "Zotsatira zoyipa").
Mankhwalawa amatha kuperekedwa kwa odwala omwe kudya kwawo nthawi zonse ndikuphatikiza chakudya cham'mawa. Ndikofunika kwambiri kuti pakhale chakudya chokwanira chamafuta pang'ono ndi chakudya, chifukwa chiopsezo chokhala ndi hypoglycemia chimakulirakudya chochepa kapena choperewera, komanso pakudya chakudya choperewera m'thupi.
Hypoglycemia nthawi zambiri imayamba kukhala ndi zakudya zochepa zopatsa mphamvu, pambuyo pochita masewera olimbitsa thupi kwa nthawi yayitali kapena mwamphamvu, mutamwa mowa, kapena mumamwa mankhwala angapo a hypoglycemic nthawi yomweyo.
Nthawi zambiri, zizindikiro za hypoglycemia zimatha pambuyo podya chakudya chopatsa thanzi (monga shuga). Tiyenera kukumbukira kuti kutenga zotsekemera sikumathandiza kuthetsa zizindikiro za hypoglycemic. Kugwiritsa ntchito njira zina zochokera mu sulfonylurea kumapereka lingaliro lakuti hypoglycemia imatha kubwereranso ngakhale mutapumula koyenera. Ngati zizindikiro za hypoglycemic zimatchulidwa kapena ndizokhalitsa, ngakhale pakhale kusintha kwakanthawi mutatha kudya chakudya chamafuta ambiri, chithandizo chamankhwala chodzidzimu ndikofunikira, mpaka kuchipatala.
Kuti mupewe kukula kwa hypoglycemia, kusankha mosamala mankhwala ndi mankhwala ena, ndikofunikira kupatsa wodwalayo chidziwitso chonse chamankhwala.

Chiwopsezo chowonjezeka cha hypoglycemia chitha kupezeka pazotsatirazi:

kukana kapena kulephera kwa wodwala (makamaka okalamba) kutsatira zomwe dokotalayo wapereka ndikuwunika momwe alili,
Zakudya zosakwanira komanso zosagwirizana, kulumpha zakudya, kusala komanso kusintha zakudya,
kusagwirizana pakati pa zolimbitsa thupi ndi kuchuluka kwa chakudya chotengedwa,
kulephera kwa aimpso
kulephera kwambiri kwa chiwindi
mankhwala osokoneza bongo a Diabeteson ® MV,
zovuta zina za endocrine: matenda a chithokomiro, kuchepa kwa pituitary ndi adrenal,
kugwiritsa ntchito munthawi yomweyo mankhwala ena (onani gawo "Kuyanjana ndi mankhwala ena").

Kulephera kwamkati ndi chiwindi
Odwala omwe ali ndi hepatic komanso / kapena aimpso kulephera, pharmacokinetic ndi / kapena pharmacodynamic katundu wa gliclazide angasinthe. Mkhalidwe wa hypoglycemia womwe umayamba mwa odwala amatha nthawi yayitali, m'malo oterowo, chithandizo chamankhwala chofunikira ndikofunikira.

Zidziwitso Zodwala
Ndikofunikira kudziwitsa wodwalayo, komanso anthu am'banja lake, za chiopsezo chotenga hypoglycemia, zizindikiro zake komanso zikhalidwe zomwe zimapangitsa kuti akule. Wodwala ayenera kudziwitsidwa za zoopsa zomwe zingachitike ndi chithandizo cha chithandizo chomwe akufuna.
Wodwala amafunika kufotokoza bwino kufunika kwa kudya, kufunika kochita masewera olimbitsa thupi nthawi zonse ndikuwunika kuchuluka kwa shuga m'magazi.

Kusakwanitsa kuyang'anira glycemic
Kuwongolera kwa glycemic mwa odwala omwe amalandira chithandizo cha hypoglycemic kungafooketse pazotsatirazi: kutentha thupi, kuvulala, matenda opatsirana, kapena kuchitidwa opaleshoni yayikulu. Ndi mikhalidwe imeneyi, zingakhale zofunikira kusiya mankhwala ndi mankhwala a shuga a Diabeteson ® MV ndikupereka mankhwala a insulin.
Odwala ambiri, mphamvu ya othandizira pakamwa hypoglycemic, kuphatikizapo gliclazide, amayamba kuchepa pambuyo pakupita nthawi yayitali. Izi zimatha kukhala chifukwa cha kupitilira kwa matendawa komanso kuchepa kwa yankho la mankhwalawa. Vutoli limadziwika kuti yachiwiri kukana mankhwala, lomwe liyenera kusiyanitsidwa ndi loyambirira, momwe mankhwalawo samaperekanso chiwopsezo chachipatala koyamba. Musanazindikire wodwala ndi kukana kwachiwiri kwa mankhwala, ndikofunikira kuyesa kuchuluka kwa kusankha kwa mankhwalawa ndikutsatira wodwala malinga ndi zakudya zomwe wapatsidwa.

Mayeso a labu
Kuti mupeze kuyang'anira glycemic, kutsimikiza kutsata glucose wamagazi ndi glycated hemoglobin HbA1c tikulimbikitsidwa.
Kuphatikiza apo, ndikofunikira kuti nthawi zonse azichita kudziwunika kwa shuga wamagazi.
Zotumphukira za Sulfonylurea zimatha kupangitsa hemolytic kuchepa magazi kwa odwala omwe ali ndi shuga-6-phosphate dehydrogenase. Popeza gliclazide imachokera ku sulfonylurea, chisamaliro chimayenera kuthandizidwa pakaperekedwa kwa odwala omwe ali ndi vuto la shuga-6-phosphate dehydrogenase.
Kuthekera kopereka mankhwala a hypoglycemic a gulu lina kuyenera kuwunikiridwa.

KUMVETSA KWAULERE KUTI MUZILIMBITSA ZINSINSI NDI MIYANI
Chifukwa cha chitukuko cha hypoglycemia chogwiritsira ntchito mankhwalawa Diabeteson ® MV, odwala ayenera kudziwa zomwe akuwonetsa mu hypoglycemia ndipo ayenera kusamala poyendetsa magalimoto kapena kugwira ntchito yofunika kuthamanga kwambiri kwamthupi komanso m'maganizo, makamaka kumayambiriro kwa chithandizo.

MALO A ISSUE
Mapiritsi a 60 mg osinthidwa
30 mapiritsi pachimake (PVC / Al), matuza 1 kapena 2 okhala ndi malangizo ogwiritsira ntchito kuchipatala mukatoni.
Mukamayala (ma CD) ku Russia kampani LLC Serdix:
30 mapiritsi pachimake (PVC / Al), matuza 1 kapena 2 okhala ndi malangizo ogwiritsira ntchito kuchipatala mukatoni.
Mapiritsi 15 pa chithuza chimodzi (PVC / Al), matuza awiri kapena anayi okhala ndi malangizo ogwiritsira ntchito kuchipatala mukatoni.
Ndikupanga ku Russia Enterprise LLC Serdix
Mapiritsi 15 pa chithuza cha PVC / Al. Kwa matuza awiri kapena anayi omwe ali ndi malangizo ogwiritsira ntchito zachipatala muthumba la makatoni.

CHITSANZO CHOKHA
Zosungira zapadera sizofunikira.
Pewani kufikira ana.

MOYO WABWINO
Zaka 2 Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

VACATION TERMS
Ndi mankhwala.

WOPHUNZITSA
Labs Serviceier, France
Serdix LLC, Russia

Satifiketi Yovomerezeka Yotumizidwa ndi a Server Laboratories, France;

"Laboratories Wantchito Makampani":
905, msewu waukulu wa Saran, 45520 Gidey, France
905, njira kuchokera ku Saran, 45520 Gidy, France

Mwa mafunso onse, funsani ofesi ya Representative of JSC "Servicework Laborator".

Zoyimira JSC "Laborator Labour":
115054, Moscow, Paveletskaya pl. d.2, p. 3

Pankhani ya ma CD ndi / kapena ma paketi / kupanga ku LLC Serdiks, Russia
Serdix LLC:
Russia, Moscow

Diabeteson MV: Malangizo ntchito

Mankhwala amatengedwa pakamwa, kamodzi patsiku (makamaka pakudya kadzutsa). Sikulimbikitsidwa kupera kapena kutafuna piritsi.

Mlingo watsiku ndi tsiku wa Diabeteson MV umasiyana 30 mpaka 120 mg mu mlingo umodzi. Ngati mukusowa tsiku limodzi kapena masiku angapo a chithandizo, simungakulitse mlingo wotsatira.

Mlingo wa mankhwalawa umasankhidwa payekha poganizira zomwe zikuwonetsa kuchuluka kwa shuga m'magazi komanso kuchuluka kwa glycogemoglobin (HbA1c).

Kumayambiriro kwa chithandizo, Diabeteson MV 30 mg patsiku amalembedwa (kuphatikiza odwala okalamba azaka 65 ndi akulu). Ndiwongolera wokwanira, gliclazide pamtengowu ungagwiritsidwe ntchito ngati kukonza mankhwala. Pankhani ya kusakwanira kwa glycemic, mankhwalawa amatha kuchuluka (60), 90 mg kapena 120 mg patsiku.

Mlingo ungathe kuwonjezeka pambuyo pa mwezi umodzi wopezeka ndi mankhwalawa gliclazide muyezo womwe umalonjezedwa, kupatula kwa odwala omwe shuga ya m'magazi sanatsike pambuyo pa masabata awiri akugwiritsa ntchito mankhwalawa. Odwala oterewa amatha kuonjezera mlingo pambuyo pa masabata awiri achithandizo.

Mlingo waukulu wa Diabeteson MV ndi 120 mg patsiku.

Mukasintha kuchokera ku mankhwala a Diabeteson (80 mg wa gliclazide) kupita ku Diabeteson MV, piritsi limodzi la Diabeteson limasinthidwa kukhala theka la piritsi la Diabeteson MV 60 mg. Kusinthaku kumachitika motsogozedwa mosamala glycemic.

Diabeteson MV imatha kutengedwa m'malo mwa othandizira ena pakamwa. Mukasamutsa wodwala, mlingo wa mankhwala ogwiritsiridwa ntchito a hypoglycemic ndi theka lake la moyo umawaganiziridwa. Nthawi zambiri palibe nthawi yosinthira yomwe imafunikira. Mlingo woyambirira wa Diabeteson MV ndi 30 mg ndipo pambuyo pake umasinthidwa malinga ndi kuchuluka kwa shuga m'magazi.

Ngati wodwalayo watenga mankhwala ena a sulfonylurea atachotsa theka moyo, ndikofunikira kusiya chithandizo kwa masiku angapo ndipo atangoyamba kumwa Diabeteson MV (kupewa hypoglycemia, yomwe ingachitike chifukwa cha kuwonjezereka kwa mankhwala awiri a hypoglycemic).

Gliclazide ikhoza kuphatikizidwa ndi alpha-glucosidase inhibitors, insulin kapena biguanidines.

Pankhani ya kuperewera kwa glycemic, chithandizo cha insulin chimachitika nthawi yomweyo ndikuyang'aniridwa ndi achipatala.

Kwa odwala azaka zapakati pa 65 ndi kupitirira, komanso odwala omwe ali ndi vuto lochepa kwambiri laimpso, kusintha kwa mankhwalawa sikofunikira.

Pamaso pa contraindication wachibale, Diabeteson MV imagwiritsidwa ntchito muyezo woyenera (30 mg patsiku).

Zotsatira zoyipa

kupukusa m'mimba: kusanza, m'mimba kupweteka, kusanza, kudzimbidwa kapena kutsekula m'mimba (kumwa gliclazide nthawi yam'mawa kumachepetsa kuthekera kwa zizindikirozi),
chiwindi ndi biliary thirakiti: kuchuluka kwa transaminase ya chiwindi, milandu yokhayokha - hepatitis (kuletsa chithandizo kumafunika),
dongosolo la lymphatic ndi ziwalo za hematopoietic: kawirikawiri - leukopenia, kuchepa magazi, granulocytopenia, thrombocytopenia (kusowa pambuyo posiya mankhwala).
khungu ndi mafuta obisika: kuyabwa pakhungu, erythema, zidzolo, urticaria, maculopapular zidzolo, angioedema, zamphamvu zimachitikira,
ziwalo zam'malingaliro: kusokonezeka kowoneka kwakanthawi chifukwa cha kusintha kwa kuchuluka kwa shuga, makamaka kumayambiriro kwa chithandizo.

Mankhwala a Diabeteson MV, hypoglycemia imatha kupezeka, makamaka ndi zakudya zosamveka bwino kapena kudumphira chakudya cham'mawa, nkhomaliro kapena chakudya chamadzulo. Zizindikiro za hypoglycemia ndi: nseru, kugona kwambiri, kusanza, kupweteka mutu, kusakwiya, kuchepa kwakukhudzika mtima, kutopa, kukwiya, kuyendetsa pang'onopang'ono, kusowa tulo, chisokonezo, kunjenjemera, kumva kusowa pogwira, kukhumudwa, kuyankhula modandaula komanso kuwona, kulephera kudziletsa, kupsinjika, paresis, kuzindikira kwa msempha, kupsinjika, phazi, bradycardia, kupuma kosakhazikika, chizungulire, kufooka, kugona, kugona, kugona, chikumbumtima. Zotsatira zotsatirazi za adrenergic zitha kuchitika: nkhawa, hyperhidrosis, tachycardia, palpitations, angina pectoris, khungu kukhuthala, kuthamanga kwa magazi ndi khungu.

Nthawi zambiri, zizindikiro za hypoglycemia zimayimitsidwa bwino ndi kudya shuga (chakudya). Zokoma sizothandiza. Ngati pambuyo popuma mpumulo wa hypoglycemia wodwala amatenga njira zina zochokera ku sulfonylurea, kuyambiranso kutha kuchitika mobwerezabwereza. Ngati hypoglycemia yakhalapo kwanthawi yayitali, chisamaliro chamankhwala chimalimbikitsidwa (mpaka kuchipatala), ngakhale ngati zizindikilo zimayimitsidwa ndikudziyendetsa yokha mafuta.

Nthawi zina mankhwalawa amatha kuyambitsa zotsatira zotsatirazi kuchokera kuzomwe zimapezeka mu sulfonylurea: hemolytic anemia, erythrocytopenia, pancytopenia, hyponatremia, agranulocytosis, alculgic vasculitis.

Malangizo apadera

Diabeteson MV imatha kulembedwa kwa okhawo omwe samadumphira chakudya ndipo amakhala ndi chakudya cham'mawa nthawi zonse. Ndikofunika kuti musamadye chakudya chokwanira chambiri kuchokera ku chakudya komanso kupewa zakudya zamafuta ochepa. Chiwopsezo cha hypoglycemia chikuwonjezeka pazotsatirazi:

kulephera kwambiri kwa chiwindi
kulephera kwa aimpso
kukhalapo kwa matenda ena a endocrine (adrenal and pituitary insuffuffence, matenda a chithokomiro),
Zakudya zoperewera komanso zopanda chakudya, kusala kudya, kudumpha zakudya, kusintha zakudya,
kusagwirizana pakati pa kuchuluka kwa chakudya chamafuta omwe amaperekedwa ndi chakudya ndi zolimbitsa thupi,
kugwiritsa ntchito munthawi yomweyo mankhwala ena (onani gawo "Drug Interaction"),
bongo wa gliclazide,
kulephera kapena kukana kwa wodwalayo (makamaka mu ukalamba) kuwongolera mkhalidwe wake ndikutsatira malangizo a dokotala.

Kuchepetsa kuwongolera kwa glycemic kumaloledwa mwa odwala omwe akuvulala, chithandizo chachikulu cha opaleshoni, matenda opatsirana kapena kutentha thupi. Milandu imeneyi, kuchotsedwa kwa Diabeteson MV ndi makonzedwe a insulin angafunike.

Odwala ambiri, mphamvu ya othandizira pakamwa imatha kuchepa pakapita nthawi.

Kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya gliclazide imatheka ndikugwiritsa ntchito munthawi yomweyo ndi miconazole (kuphatikiza uku kumatsutsana, chifukwa kungayambitse kukula kwa chikomokere), phenylbutazone ndi ethanol (mphamvu ya hypoglycemic imatheka).

Chifukwa cha chiwopsezo cha hypoglycemia, Diabeteson MV iyenera kugwiritsidwa ntchito mosamala ndi mankhwala otsatirawa: othandizira a hypoglycemic (acarbose, insulin, thiazolidatediones, metformin, dipeptidyl peptidase-4 zoletsa), fluconazole, beta-adrenergic blocking agents, sulfonamides, angiotensin capinclinckin, exiotininselininselin, exioteininselin, exioteininselin, exioteininselin, exioteininselin, exioteininselin, exioteininselinin, exiotein. mankhwala odana ndi kutupa, histamine H blockers₂receptors, monoamine oxidase inhibitors.

Mphamvu ya gliclazide imafooketsa danazol (kuphatikiza uku sikulimbikitsidwa), chlorpromazine, glucocorticosteroids nthawi imodzi ndi tetracosactide ndi beta₂-adrenomimetics. Mankhwalawa amagwiritsidwa ntchito mosamala komanso moyang'aniridwa ndi glycemic.

Gliclazide ikhoza kupititsa patsogolo zotsatira za anticoagulants.

Zofanizira za Diabeteson MV ndi Gliclazide MV, Gliclazide-AKOS, Gliclazide Canon, Gliclazide MV Pharmstandard, Golda MV, Glidiab, Gliklada, Diabetalong, Glidiab MV, Diabefarm, Glyclazid-SZ, Diabinax, Diabefarm MV, etc.

Ndemanga za Diabeteson MV

Odwala amasiya ndemanga zabwino kwambiri za Diabeteson MV. Ichi ndi mankhwala othandizadi omwe amathandizira kuti shuga azikhala bwino. Gliclazide samakonda kuyambitsa thupi lawo siligwirizana komanso mavuto ena. Ndikosavuta kumwa mapiritsi, popeza mlingo wa tsiku ndi tsiku umapangidwira mlingo umodzi. Kuchiza ndi Diabeteson MV ndi njira ina yabwino yothandizira insulin.

Kudzipereka kwa mankhwalawa, malinga ndi odwala: kufunika kogwiritsa ntchito mosalekeza, sikungaperekedwe kwa ana, chiopsezo cha hypoglycemia, mtengo wokwera, zochita za gliclazide.