Kuyerekezera kwa Drotaverin ndi No-Shp

Drotaverine
Drotaverine
Pake wa mankhwala
IUPAC	(1- (3,4-diethoxybenzylidene) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline (monga hydrochloride)
Choyimira chokha	C24H31AYI4
Unyinji wa Molar	397,507 g / mol
Cas	985-12-6
PubChem	1712095
Drugbank	06751
Gulu
ATX	A03AD02
Pharmacokinetics
Bioava	100 %
Kumanga Mapuloteni a Plasma	80 mpaka 95%
Kupenda	Chiwindi
Hafu ya moyo.	kuyambira 7 mpaka 12 maola
Kupatula	Katemera ndi impso
Mlingo Wamitundu
mapiritsi, ampoules
Mayina ena
Bioshpa, Vero-Drotaverin, Droverin, Drotaverin, Drotaverin forte, Drotaverin hydrochloride, No-shpa ®, No-shpa ® forte, NOSH-BRA ®, Spazmol ®, Spazmonet, Spazoverin, Spakovin

Drotaverine (1- (3,4-diethoxybenzylidene) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline (monga hydrochloride) - mankhwala okhala ndi antispasmodic, myotropic, vasodilator, hypotensive.

Mlingo

Drotaverin adapangidwa mu 1961 ndiogwira ntchito ku kampani yopanga zamankhwala ku Hungary Hinoin. Mpaka nthawi iyi, kampaniyi idakhala ndi miyambo yayitali pakupanga mankhwala a antispasmodic. Papaverine wopangidwa ndi Quinoin wakhala akugwiritsidwa ntchito bwino muzochita zamankhwala kwazaka zambiri. Pazofufuza zasayansi kuti zithandizire kupanga papaverine ndikuthandizira kupanga kwachuma, chinthu chatsopano chidapezeka. Katunduyu, wotchedwa drotaverine, anali wapamwamba kangapo kuposa papaverine pakugwira ntchito kwake. Mu 1962, mankhwalawa anali ndi dzina lobwera chifukwa cha dzina la malonda la No-Shpa. Ndizofunikira kudziwa kuti m'dzina lino zochita zamankhwala zimawonetsedwa. Mu Chilatini, zimamveka ngati No-Spa, zomwe zikutanthauza kuti Palibe kuphipha, palibe kuphipha. Mankhwalawa adakumana ndi mayeso azachipatala angapo, ndipo chitetezo chake chakhala chikuwunikidwa mosamala kwazaka zambiri. Chifukwa chakuchita bwino, kusavulazidwa pang'ono komanso mtengo wotsika, mankhwalawo adayamba kutchuka. Ku Soviet Union, No-Shpu idayamba kugwiritsidwa ntchito m'ma 1970. Pambuyo pake, Hinoin adakhala gawo la kampani yopanga zamankhwala Sanofi Syntelabo, yomwe malonda ake amagwirizana kwambiri ndi mayiko akunja. Pakadali pano, No-Shpu akupitilizabe kugwiritsidwa ntchito m'maiko opitilira 50 padziko lapansi, kuphatikiza ku Russia komanso m'maiko ambiri a Soviet Union.

Mlingo wa mawonekedwe |Khalidwe No-shp

Mankhwala angagulidwe monga mapiritsi ndi yankho lomwe limagwiritsidwa ntchito kupanga jakisoni (intravenously and intramuscularly). Chofunikira kwambiri ndi drotaverine hydrochloride. Njira yothetsera vutoli imagwiritsidwa ntchito pochotsa chizindikiro cha kupweteka kwa msana, komwe kumatha kupezeka m'thupi lathu.

Mankhwala No-shpa adapangidwira kuti agwiritse ntchito ngati njira yayikulu komanso yothandizira. Poyambirira, ndikofunikira kuti mupereke mankhwalawa chifukwa cha kupweteka kwam'mimba komanso kwamikodzo dongosolo.

Kuyerekezera Mankhwala

Posankha mankhwala, ndikofunikira kujambula kufanana pakati pa njira zoyenera kwambiri pazinthu zingapo: mtundu wa chinthu chogwira ntchito, seti ya zakupatsani, Mlingo, mawonekedwe omasulidwa, njira yochitira, zikuwonetsa, zotsutsana, mtengo, mavuto, kuyanjana ndi mankhwala ena, kuthana ndi kuthekera koyendetsa galimoto .

Mukamasankha pakati pa zidazi, amatenga chidwi pazofanana, mawonekedwe a mankhwalawa. Mankhwalawa ali ndi chinthu chimodzi chogwira ntchito (drotaverine hydrochloride), amagwiritsa ntchito mfundo imodzi. Mlingo wa chinthuchi sichisinthanso - 40 ml mwanjira iliyonse yotulutsidwa. Chifukwa chake, mankhwalawa a mankhwalawa amakhalabe amodzimodzi.

Mankhwala onse awiriwa amaperekedwa malinga ndi mtundu wa matenda. Gawo lolimbikira mu kapangidwe kake limatulutsa kukula kwa zotsatira zoyipa. Chifukwa chake, zotsutsana pakugwiritsira ntchito mankhwala sizimasiyana. Alumali moyo wa mankhwalawo umagwirizana, zomwe zimachitika chifukwa cha kupezeka kwa zigawo zothandizirana zomwezi.

Mankhwala omwe ali ndi drotaverine hydrochloride angagwiritsidwe ntchito pochiritsa amayi apakati. Mankhwala onse awiriwa samathandizira kuti pakhale zovuta zoyipa zomwe zingayambitse kukana kuyendetsa galimoto. Malinga ndi magawo angapo, mankhwalawa amasinthana.

Kodi pali kusiyana kotani?

Kusiyana kwa mankhwala amitundu iyi ndizochepa. Zimadziwika kuti amapangidwa m'njira zosiyanasiyana. Chifukwa chake, pali zosankha zochepa za Drotaverin kuposa No-shp. Chida ichi chitha kugulidwa m'matumba a mapiritsi 10 kuchuluka kwa ma PC 1. mu paketi imodzi. Pali mitundu yosiyanasiyana ya mankhwalawa ngati botolo lomwe lili ndi mapiritsi 100.

No-spa imapezeka m'mapiritsi a 6, 10 ndi 20 ma PC. mu 1 chithuza. Mu botolo, mutha kugula chinthu chomwe chili ndi ma 64 ndi 100 ma PC. Pali zosankha zambiri, zomwe zimakulitsa chisankho mogwirizana ndi zomwe dokotala wakupatsani; simuyenera kugula mankhwala ambiri ngati mukufunikira chithandizo chamankhwala ochepa.

Kapangidwe ka drotaverin palinso mankhwala a crospovidone. Ichi ndi gawo lothandiza. Ilibe mphamvu ya antispasmodic. Amagwiritsidwa ntchito ngati enterosorbent. Kusiyana kwina ndi mtundu wa mapaketi otupa omwe amakhala ndi mapiritsi. Mwachitsanzo, Drotaverin akhoza kugulidwa m'mapaketi amtundu wa cell opangidwa ndi PVZ / aluminium. Moyo wa alumali wa mapiritsi pamenepa ndi zaka zitatu. Poyerekeza, No-shpa imapezeka m'mitundu yosiyanasiyana: PVC / aluminium ndi aluminium / aluminium. Otsiriza a iwo akhoza kusungidwa kwa zaka 5 popanda chiwopsezo cha kuwonongeka kwa katundu.

Zomwe zimakhala zotsika mtengo

Pamtengo Drotaverin amenya analogue. Mutha kugula mankhwalawa kwa ma ruble 30-140. kutengera kuchuluka kwa mapiritsi. Koma spa ndiyokwera mtengo kwambiri, ndi ya gulu la mankhwala omwe ali m'gulu la mitengo yapakati. Ngakhale izi, mtengo wazinthu izi ndizovomerezeka: 70-500 rubles. Mankhwala onsewa atha kugulidwa ndi odwala azikhalidwe zosiyanasiyana. Komabe, Drotaverin adzawonedwa ngati kugula kovomerezeka.

Pa mimba ndi mkaka wa m`mawere

Pakubala kwa mwana, onse mankhwala amaloledwa kugwiritsidwa ntchito. Izi ndichifukwa cha kapangidwe kake, zomwe zili muzinthu zomwezo. Ndikofunika kusamala, chifukwa chilichonse chomwe chimachitika m'matumbo chitha kubweretsa chitukuko cha hypotension, chomwe chili chowopsa nthawi yapakati, makamaka ngati pali chizolowezi chochepetsa kwambiri kupanikizika.

Nthawi ya mkaka wa m'mawere imatchula mndandanda wa contraindication. Komanso, No-spa, monga Drotaverin, sangathe kugwiritsidwa ntchito mu thupi.

Malingaliro a madotolo

Vasiliev E. G., wazaka 48, St. Petersburg

Nthawi zambiri ndimalemba mankhwala aku Hungary (No-shpu). Muli ndi drotaverine. Machitidwe anga kunalibe odwala omwe amabwera ndi madandaulo okhudza mankhwalawa. Palibe zoyipa, zovuta. Popeza ndidakumana ndi zovuta, ndimakonda mankhwalawa. Ndipo ndikumvetsa kuti kapangidwe ka Drotaverin ali ofanana, koma ndimafuna kutsimikiziridwa kuti No-shpa.

Andreev E. D., wazaka 36, ​​Kerch

Ndikukhulupirira kuti kukonzekera komwe komwe kumapangidwa kungathe kusintha. Ndine m'modzi mwa madotolo omwe amandipatsa mankhwala ocheperako, osati kuchuluka kwa mankhwala. Drotaverin ndiyotsika mtengo kwambiri, iyi ndiye phindu lake lalikulu. Kuphatikiza apo, chida ichi chimapezeka ku Russia, chifukwa chake ndimathandizira opanga zapakhomo.

Zomwe spasmolytics zimathandizira kuchokera: Zizindikiro zogwiritsidwa ntchito

Kutengera ndi dzina, antispasmodics ndikofunikira kuti masheya a minofu yosalala. Komabe, sizikhudza magwiridwe antchito amanjenje, osaphwanya mawonedwe. Drotaverin ndi No-shpa amagwiritsidwa ntchito:

1. Gynecology. Chofunikira kwambiri pakupumula kwa ululu pambuyo pa gawo la cesarean, hypertonicity ya chiberekero, kuopseza padera kapena kubadwa msanga,
2. Cardiology ndi mitsempha. Kuphipha kwa mitsempha yayikulu ndi mitsempha kumachotsedwa, kuthamanga kwa magazi kumachepa,
3. Gastroenterology ndi Urology. Kutupa njira mabakiteriya, kachilombo koyambira, poyizoni wa chakudya, kusayenda kwa ndulu.

Akatswiri ena amalimbikitsa kugwiritsa ntchito chinthu chothandizira ngati chithandizo chobwezeretsa pambuyo povulala, kulowererapo.

Ma analgesics samachotsa zomwe zimayambitsa malungo, koma ndithandizireni kwakanthawi chizindikirocho. Chifukwa chake, chiopsezo chachikulu cha zovuta ndi makina osatsata. Madokotala amalimbikira pa izi. Kudya kwakanthawi kamodzi kwa Drotaverinum kapena No-shp kulibe vuto.

Ma antispasmodic ali ndi zotsutsana:

• Chiwindi kapena kulephera kwa impso
• Wodwala wosakwana zaka 6
• Pathologies a mtima dongosolo mu pachimake gawo kapena kumapeto magawo.

Mankhwala osavomerezeka akuyamwitsa. Koma pamavuto, malinga ndi mlingo wa tsiku ndi tsiku, sizikhudza mayi ndi mwana.

Nthawi zambiri pa intaneti pamakhala kuyerekezera kwa mankhwala. Kupatula apo, ali ndi zotsatira zofananira, ndipo No-shpa ndi analogue yamtengo wapatali ya Drotaverin.

Kufotokozera zamankhwala

Zochita za gawo la mankhwalawo ndicholinga chopetsa kuphipha. Mawonekedwe osalala a minofu imaphwanyidwa pampu wa sodium-potaziyamu, kuchoka kwa madzi bwino. Imathandizira kuthetsa kuphipha kwa ziwalo zokha, komanso mitsempha yamagazi. Chifukwa chake, angagwiritsidwe ntchito kuthana ndi migraines, kuchepetsa zizindikiro za matenda amisala. Poterepa, analgesic sichikhudza dongosolo lamanjenje. Chifukwa chake, zitha kutengedwa ndi odwala ndikuphwanya kubadwa kwa ziwalo.

Mankhwalawa amathandizira pakatha mphindi 12 atalowa m'mimba. Amayamwa pambuyo pa maola 12 ndi impso. Panthawi imeneyi, zinthu zimateteza ku zowawa zamtundu uliwonse komanso zachilengedwe.

Kuyerekeza Mtengo

Drotaverin ndi analogue apakhomo. Ili ndi dzina lapadziko lonse, losadziwika, mosiyana ndi No-shpa. Chifukwa chake, mtengo wake umakhala wotsika kangapo. Kuchita bwino kwa analgesics ndikofanana, zotsatira zake ndizofanana. Mtengo wachindunji wa analgesic umadalira pa network ya pharmacy, markups amalonda ndi zina zowonjezera. Tiyeneranso kudziwa kuti Drotaverin ndiwopanga zoweta, ndipo No-shpa imalowetsedwa. Izi zimakhudza kapangidwe ka mitengo.

Zomwe zingakhale zotetezeka nthawi yayitali komanso mkaka wa m'mawere

Pa mimba ndi mkaka wa m`mawere, kusankha mosamala mankhwala. Dokotala yekha, wodalira kafukufuku ndi Zizindikiro, amasankha analgesic pochiritsira. Ndikofunika kuti mankhwalawa sayambitsa kusowa kwa placental, zolakwika za kukhazikika kwa ubongo ndi thupi la mwana, chinthu chogwira ntchito sichidziunjikira mkaka wa m'mawere. Ngati mkhalidwewo uli wowopsa thanzi la mayi, mwachitsanzo, pambuyo pa gawo laeses, ndiye kuti madokotala amapereka No-shpa kapena Drotaverin. Ndikofunika kumwa kwa analgesic malinga ndi malangizo, osapitilira nthawi kapena pafupipafupi kumwa mankhwalawo.

Mfundo zochita za antispasmodic mankhwala

Mankhwala a Antispasmodic ndi mankhwala opangidwa kuti athetse kuphipha kwa minofu yamkati yamkati (m'mimba, bronchi, mitsempha yamagazi, kwamkodzo komanso biliary). Pali ma neurotropic ndi myotropic omwe amagwira ntchito a antispasmodics:

• neurotropic - zotchinga mitsempha, zomwe zimayambitsa kuphipha kwa minofu yosalala. Kuletsa kumachitika pamlingo wamkati wamanjenje mothandizidwa ndi mlingo wophatikizidwa ndi sedative.
• myotropic - Chitani mwachindunji paminyewa yosalala.

Drotaverin ndi No-shpa ndi mankhwala a myotropic antispasmodic omwe ali ndi hypotensive ndi vasodilating katundu.

Mankhwala omwe amagwiritsidwa ntchito onse awiriwa ndi Drotaverine (drotaverine). Amachepetsa kukhudzika kwa calcium calcium ion (Ca2 +) m'maselo osalala a minofu popewa phosphodiesterase komanso kuchuluka kwa cAMP. Mwachangu komanso odzipereka kwathunthu m'mimba. Mukamayendetsa, bioavailability ya drotaverine imayandikira 100%, ndipo nthawi yake yodzaza theka ndi mphindi 12. Amachotsa impso.

Zisonyezero zogwiritsira ntchito mapiritsi

Zochizira, mankhwalawa amagwiritsidwa ntchito ngati spasms ya minofu yosalala yokhudzana ndi matenda:

• biliary thirakiti (cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis),
• kwamikodzo thirakiti (nephrolithiasis, urethrolithiasis, pyelitis, cystitis, tenesmus ya chikhodzodzo).

Monga chithandizo chothandizira:

• Ndi ma spasms a yosalala minofu yam'mimba ya m'mimba
• ndi matenda oopsa
• ndi kapamba,
• ndi mutu wopsinjika chifukwa cha nkhawa,
• ndi matenda a gynecological (dysmenorrhea).

Mimba komanso kuyamwa

Kukhazikitsa pakamwa kwa mankhwalawa sikukhudza kutenga pakati, kubereka, kulera mwana kapena nthawi yobereka. Koma ndikulimbikitsidwa kuti mupereke mankhwalawa kwa amayi apakati mosamala. Panthawi ya mkaka ndi mkaka wa m`mawere, mankhwalawa omwe ali ndi drotaverine sanalembedwe, chifukwa palibe chidziwitso chazotetezedwa chotere.

Zotsatira zoyipa

Mukamamwa antispasmodics zochokera ku drotaverine, kusokonezeka kwa chitetezo cha m'thupi komwe kumawonetsedwa kawirikawiri monga zotsatira zoyipa sizimawonetsedwa, izi ndi:

• angioedema,
• urticaria
• zotupa
• kuyabwa
• Hyperemia pakhungu,
• malungo
• kuzizira
• malungo
• kufooka.

Kuchokera ku CCC mbali ikhoza kuonedwa:

• kukomoka mtima,
• ochepa hypotension.

Matenda a CNS amawoneka ngati:

• mutu
• chizungulire
• kusowa tulo

Mankhwala angayambitse kusowa kwa m'mimba:

Contraindication

Zoyipa zotsutsana ndi mankhwalawa ndi:

• Hypersensitivity to drotaverine kapena mankhwala aliwonse
• kwambiri kwa chiwindi, aimpso, kapena kulephera kwa mtima.

Mankhwalawa onse amachepetsa kuthamanga kwa magazi, motero amagwiritsidwa ntchito mosamala ngati vuto lakelo layamba kuchepa.

No-shpu ndi drotaverin sangagwiritsidwe ntchito kuchiritsa odwala omwe ali ndi matenda amtundu wa makolo, monga:

• galactose tsankho,
• Lapp lactase akusowa,
• shuga-galactose malabsorption syndrome.

Kuchita ndi mankhwala ena

Mosamala, mankhwalawa amagwiritsidwa ntchito nthawi yomweyo ndi Levodopa, chifukwa mphamvu ya antiparkinsonia ya mankhwalawa imachepa, kuuma komanso kuwonjezeka.

Mankhwalawa amawonjezeka:

• antispasmodic zochita za zinthu zina antispasmodic,
• hypotension chifukwa cha tricyclic antidepressants.

Drotaverine amachepetsa spasmogenic ntchito ya morphine.

Kulimbikitsa mphamvu ya antispasmodic ya drotaverine kumachitika pamene kuphatikiza phenobarbital.

Kuyenderana ndi mowa

Ngakhale kumwa mankhwalawa ndi mowa, zotsatirapo zoyipa zingachitike:

• chizungulire
• kusowa tulo
• kutsika kwa magazi,
• kukodza pafupipafupi
• kusanza kapena kusanza
• kukanika kwa mtima,
• kuchuluka kwa mtima,
• kuchepa kwa chitetezo chamthupi.

Tsiku lotha ntchito

Mndandanda wa mankhwalawa wogwiritsidwa ntchito (drotaverine) ndi:

• Dolce (yankho la jakisoni mumiyeso ya 2 ml, 20 mg / ml), Plethiko Pharmaceuticals Ltd, India,
• Dolce-40 (mapiritsi, 40 mg), Plethiko Pharmaceuticals Ltd., India,
• Drospa Forte (mapiritsi, 80 mg), Nabros Pharm Pvt. Ltd, India
• Nispasm forte (mapiritsi, 80 mg) Mibe GmbH Artsnaymittel, Germany,
• No-x-sha (yankho mu ma ampoules a 2 ml, 20 mg / ml, mapiritsi a 40 mg kapena rectal suppositories a 40 mg) ndi No-x-sha forte (mapiritsi, 80 mg), Lekhim, ChAO, Kharkov , Ukraine,
• Nohshaverin "Oz" (yankho mu ma ampoules a 2 ml, 20 mg / ml), Chomera cha kafukufuku "GNTsLS", LLC / Health, FC, LLC, Ukraine,
• Ple-Spa (p / o mapiritsi, 40 mg kapena jakisoni yankho mu ampoules a 2 ml, 20 mg / ml), Plethiko Pharmaceuticals Ltd, India,
• Spazoverin (mapiritsi, 40 mg), Shreya Life Science Pvt. Ltd, India.

Mtengo wa mankhwala

Nikolaeva R.V., wothandizira: "Sindikulimbikitsa kugula No-shpu okwera mtengo chifukwa chogwiritsa ntchito nthawi yayitali, popeza Drotaverin amagwiranso ntchito chimodzimodzi. Ngati mankhwalawa amwedwa piritsi limodzi ndi theka, ndiye kuti palibe kusiyana pamankhwala awa. ”

Osadchy V. A., dokotala wa ana: "Pakati pa mimba, mankhwalawa amatha kuthandizidwa kuti muchepetse ululu kapena ngati pali chiopsezo cholakwika kuti muchepetse vuto la chiberekero. Koma kulandilidwa kotereku kuyenera kuyang'aniridwa ndi dokotala komanso pokhapokha ngati pakufunika kuchepetsa chiopsezo cha kubadwa isanakwane. "

Natalia, wazaka 35, Kaluga: "Nthawi zonse ndimakhala wopanda-spa mumkhalidwe wamankhwala, chifukwa mankhwalawa ndiye njira yabwino yothandizira kupweteka ndi kupsinjika panthawi ya msambo. Ndimangomvera mawu oti No-shpa m'mapiritsi okha. ”

Victor, wazaka 43, Ryazan: “Ma mapiritsi a antispasmodics samathandiza ndi kuphipha kwamkati. Jakisoni wokha amachepetsa ululu. No-spa imagwira ntchito mwachangu kuposa Drotaverin. ”

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Mfundo zochita za antispasmodic mankhwala

Kuphipha - kupindika kwapadera kwa minofu. Mikwingwirima imachitika mosiyanasiyana, kutengera ndi magulu amisempha omwe adakhudzidwa. Nthawi zambiri pakadali pano pali ululu, womwe umatha kukhala wowawa kwambiri.

Chotsani zomverera izi zimatha kupangitsa kuti antispasmodics, omwe amathandizira kupumula kwa minofu.

Vutoli limachitika pakadutsa mphindi 12, popeza chinthucho chimagwira mwachangu kuchoka m'mimba, kenako kulowa m'misempha yosalala.

Malangizo apadera

Ndikofunika kumwa mankhwalawa mosamala kwa aliyense amene ali ndi kusokonezeka kwa thupi, makamaka, anthu omwe akudwala matenda oopsa komanso matenda amtundu (galactose tsankho, kuperewera kwa lappase, glucose-galactose malabsorption).