Lantus SoloStar

Mankhwala Lantus SoloStar (Lantus solostar) imakhazikika pa analogue ya insulin ya anthu, yomwe imakhala yochepa kwambiri m'malo osavomerezeka. Chifukwa acidic malo yankho Lantus SoloStar insulin glargine itasungunuka kwathunthu, koma ndi subcutaneous makonzedwe, asidi samasankhidwa ndipo microprecipitates imapangidwa chifukwa cha kuchepa kwa kusungunuka, komwe insulin imamasulidwa pang'onopang'ono. Chifukwa chake, kuwonjezeka kwapang'onopang'ono kwa plasma wozungulira wa insulini popanda lakuthwa nsonga ndi mphamvu yautali wa mankhwala Lantus SoloStar imatheka.
Mu insulin glargine ndi insulin yaumunthu, kinetics yolumikizirana ndi insulin receptors ndi yofanana. Mbiri ndi potency wa insulin glargine ndiwofanana ndi insulin yamunthu.

Mankhwala amawongolera kagayidwe kazakudya, makamaka, amachepetsa kuchuluka kwa shuga m'magazi mwa kuchepetsa kupanga kwake mu chiwindi ndikuwonjezera kumwa kwa glucose mwa zotumphukira zimakhala (makamaka minofu ndi adipose minofu). Insulin imalepheretsa proteinolysis ndi lipolysis mu adipocytes, komanso imathandizira kuphatikiza mapuloteni.
Kuchita kwa insulin glargine, yoyendetsedwa mosadukiza, kumayamba pang'onopang'ono kuposa kukhazikitsidwa kwa insulin, ndipo imadziwika ndi kuchitapo kanthu kwakanthawi komanso kusowa kwa mfundo zazikuluzikulu. Mwanjira imeneyi Lantus SoloStar Itha kugwiritsidwa ntchito nthawi 1 patsiku. Kumbukirani kuti magwiridwe antchito ndi kutalika kwa insulin zimatha kusiyanasiyana ngakhale mwa munthu m'modzi (ndikulimbitsa thupi, kuwonjezeka kapena kuchepetsedwa kwa nkhawa, ndi zina zambiri).

Pakufufuza kwakanthawi kachipatala, zidatsimikiziridwa kuti insulin glargine siziwonjezera kupitirira kwa matenda ashuga a retinopathy (zizindikiro zakuchipatala za kugwiritsidwa ntchito kwa insulin glargine ndi insulin ya anthu sizinasiyane).
Mukamagwiritsa ntchito mankhwalawa Lantus SoloStar equilibrium insulin concentrations idakwaniritsidwa patsiku la 2-4.
Insulin glargine imapangidwa m'thupi kuti ipange ma metabolites awiri ogwira ntchito, M1 ndi M2. Udindo wofunikira pakuwona zotsatira za mankhwala Lantus SoloStar umaseweredwa ndi metabolite M1, mu plasma yosasinthika ya insulin glargine ndi metabolite M2 imatsimikiziridwa yaying'ono.
Panalibe kusiyana kwakukulu pakuwoneka bwino ndi chitetezo cha insulin glargine mwa odwala amitundu ingapo komanso odwala ambiri.

Zisonyezero zogwiritsidwa ntchito:
Lantus SoloStar ntchito zochizira odwala azaka zopitilira zisanu ndi chimodzi omwe amakhala ndi matenda a shuga.

Njira yogwiritsira ntchito:
Lantus SoloStar anaganiza kuti subcutaneous makonzedwe. Ndikulimbikitsidwa kuyambitsa mankhwala Lantus SoloStar nthawi yomweyo masana. Mlingo wa mankhwala Lantus SoloStar amasankhidwa payekha ndi dokotala. Tiyenera kudziwa kuti kuchuluka kwa mankhwalawa akufotokozedwa m'magawo omwe amagwiritsidwa ntchito mwapadera ndipo sangayerekezedwe ndi magawo a zochita zina za insulini zina.
Kugwiritsa ntchito mankhwalawa kumaloledwa Lantus SoloStar Odwala omwe ali ndi matenda a shuga 2 amaphatikizika ndi mankhwala am'kamwa.

Kusintha kuchokera ku insulin ina kupita ku Lantus SoloStar:
Mukasinthira ku Lantus SoloStar ndi ma insulin ena apakatikati kapena osakhalitsa, pangafunike kusintha mlingo wa tsiku ndi tsiku wa insulin, komanso kusintha Mlingo ndi ndandanda ya kumwa mankhwala ena a hypoglycemic. Kuchepetsa chiopsezo cha nocturnal hypoglycemia pakusintha kwa Lantus SoloStar m'milungu ingapo yoyamba, tikulimbikitsidwa kuti muchepetse insulin ya insulin ndi kukonza koyenera kwa insulin, komwe kumayambitsidwa pokhudzana ndi kudya. Masabata ochepa atayamba kugwiritsa ntchito mankhwala a Lantus SoloStar, kusintha kwa basal insulin ndi insulin kwakanthawi kumachitika.
Odwala omwe amalandira insulin kwa nthawi yayitali, kuwoneka kwa ma antibodies ku insulin ndi kuchepa kwa zomwe mankhwala a Lantus SoloStar amatha.
Mukasintha kuchokera ku insulin imodzi kupita kwina, komanso pakusintha kwa mlingo, shuga m'magazi amayenera kuyang'aniridwa mosamala kwambiri.

Kuyambitsa mankhwala Lantus SoloStar:
Mankhwala chikuyendetsedwera subcutaneous mu deltoid, ntchafu kapena pamimba dera. Ndikulimbikitsidwa kuti musinthe jakisoni wovomerezeka mkati mwa malo ovomerezeka pa jekeseni iliyonse ya mankhwala Lantus SoloStar. Ndi zoletsedwa kupereka Lantus SoloStar kudzera m'mitsempha (chifukwa cha chiwopsezo cha bongo ndi kukula kwa hypoglycemia yayikulu).
Sizoletsedwa kuphatikiza insulin glargine yankho ndi mankhwala ena.
Mukangotsala ndi insulin glargine makina, chotsani thovu kuchokera mu chidebe ndikuyesani chitetezo. Jakisoni aliyense amayenera kuchitidwa ndi singano yatsopano, yomwe imayikidwa pang'onopang'ono penipeni musanagwiritse ntchito mankhwalawa.

Kugwiritsa ntchito cholembera Lantus SoloStar:
Musanagwiritse ntchito, muyenera kuyang'ana mosamala katiriji wa cholembera, mutha kugwiritsa ntchito yankho lomveka bwino popanda kumata. Ngati pakuwoneka nthumwi, kusefukira, kapena kusintha mtundu wa yankho, kugwiritsa ntchito mankhwalawo kumaletsedwa. Ma cholembera opanda kanthu ayenera kutayidwa. Ngati cholembera chasokonekera chawonongeka, muyenera kutenga cholembera chatsopano ndikuchotsa chowonongeka.

Pamaso pa jekeseni iliyonse, kuyesedwa kwa chitetezo kuyenera kuchitidwa:
1. Onani kuyika kwa insulin ndi mawonekedwe ake.
2. Chotsani cholozera cha cholembera ndikuyika singano yatsopano (singano iyenera kusindikizidwa musanapake, ndikulephera kuphatikiza singano pakona).
3. Ganizirani kuchuluka kwa mayunitsi 2 (ngati cholembera sichinagwiritsidwepo ntchito 8 Maofiti) ikani cholembera ndi singano mmwamba, pang'onopang'ono katoniyo, ndikanikizani batani loyika njira yonse ndikuwoneka ngati dontho la insulin pamsonga pa singano.
4. Ngati ndi kotheka, kuyesedwa kwa chitetezo kumachitika kangapo mpaka yankho litawonekera pamsonga pa singano. Ngati mayesero angapo a insulin samawonekera, m'malo mwa singano. Ngati izi sizinathandize, cholembera cha syringe ndichiperewera, osachigwiritsa ntchito.

Sizoletsedwa kusinthitsa cholembera kwa anthu ena.
Nthawi zonse zimalimbikitsidwa kukhala ndi ndalama syringe cholembera Lantus SoloStar pakuwonongeka kapena kutayika kwa cholembera.
Ngati cholembera chimasungidwa mufiriji, chimayenera kuchotsedwa pakadutsa maola awiri jekeseni isanachitike kuti yankho lithe kutentha.
Cholembera cha syringe chizitetezedwa ku dothi ndi fumbi, mutha kuyeretsa kunja kwa cholembera ndi kansalu konyowa.

Sizoletsedwa kusamba cholembera Lantus SoloStar.

Kusankha:
Lantus SoloStar limakupatsani kukhazikitsa mlingo kuchokera 1 unit mpaka 80 mayunitsi mukuwonjezera kwa 1 unit. Ngati ndi kotheka, lowetsani kuchuluka kwa magawo 80 kuti mupange jakisoni zingapo.
Onetsetsani kuti pambuyo poyesa chitetezo, zenera la dosing likuwonetsa "0", sankhani mlingo wofunikira potembenuza chosankha. Mukasankha mlingo woyenera, ikani singano pakhungu ndikudinikiza batani loyika njira yonse. Mlingo waperekedwa, phindu la "0" liyenera kuyikidwa pazenera la dosing. Kusiya singano pakhungu, kuwerengera mpaka 10 ndikukoka singano kuchokera pakhungu.
Chotsani singano mu cholembera ndikuitaya, tsekani cholembera ndi chipewa ndikusunga mpaka jekeseni wotsatira.

Zotsatira zoyipa:
Mukamagwiritsa ntchito mankhwalawa Lantus SoloStar mwa odwala, kukula kwa hypoglycemia ndikotheka, chifukwa cha kukhazikitsidwa kwa insulin yayikulu, komanso kusintha kwa zakudya, zolimbitsa thupi ndi kukulitsa / kuthetseratu kwa mavuto. Hypoglycemia yayikulu ikhoza kuyambitsa kusokonezeka kwa mitsempha ndikuwopseza moyo wa wodwalayo.
Kuphatikiza apo, mukamagwiritsa ntchito mankhwalawa Lantus SoloStar Pa mayesero azachipatala odwala, zotsatirapo zoyipa zinadziwika:
Kuchokera kwamankhwala amanjenje ndi ziwalo zam'maganizo: dysgeusia, retinopathy, kuchepa kowoneka bwino. Hypoglycemia yayikulu imatha kubweretsa kukulira kwakanthawi kwamaso kwa odwala omwe ali ndi proliferative retinopathy.

Pa khungu ndi minyewa yodutsa: lipodystrophy, lipoatrophy, lipohypertrophy.
Thupi lawo siligwirizana: General khungu lawo siligwirizana, bronchospasm, anaphylactic, kugunda kwa Quincke.
Zotsatira zam'deralo: hyperemia, edema, zilonda zam'mimba ndi zotupa pa malo a jekeseni wa Lantus SoloStar.
Zina: kupweteka kwa minofu, kusungidwa kwa sodium mthupi.
Mbiri ya chitetezo chamankhwala Lantus SoloStar mwa ana opitilira 6 zaka ndi akulu nzofanana.

Zoyipa:
Lantus SoloStar osatengera odwala omwe ali ndi hypersensitivity odziwika kwa insulin glargine kapena zina zowonjezera zomwe zimapanga yankho.
Lantus SoloStar sagwiritsidwa ntchito pochiza odwala omwe ali ndi vuto laimpso ndi kwa chiwindi.
Mu machitidwe a ana, mankhwala Lantus SoloStar amagwiritsidwa ntchito pochiza ana azaka zopitilira 6.
Lantus SoloStar Osati mankhwala osankhidwa pochizira matenda ashuga a ketoacidosis.
Odwala okalamba, komanso odwala omwe ali ndi vuto la impso ndi kwa chiwindi, zofunikira za insulini zimatha kuchepa, odwala otere ayenera kuyikidwa Lantus SoloStar mosamala (kuwunika kosalekeza m'magazi a glucose).
Chenjezo liyenera kuchitika posankha odwala omwe hypoglycemia ingakhale ndi zotsatirapo zoyipa.

Makamaka, mosamala, Lantus SoloStar imalembedwa kwa odwala omwe ali ndi vuto la ubongo kapena coronary stenosis ndi proliferative retinopathy.

Chenjezo liyenera kuthandizidwa popereka Lantus SoloStar kwa odwala omwe zizindikiro za hypoglycemia zimakhala zopanda pake kapena zofatsa, kuphatikiza odwala omwe ali ndi kusintha kwa glycemic indices, mbiri yayitali ya matenda ashuga, matenda a neuronomic, matenda amisala, kukula pang'onopang'ono kwa hypoglycemia, komanso odwala okalamba komanso odwala. zomwe zimachokera ku insulin ya zinyama kupita kwa anthu.
Kusamala kuyeneranso kuchitika popereka mankhwala. Lantus SoloStar odwala omwe amakonda kukhala ndi hypoglycemia. Chiwopsezo cha kukhala ndi hypoglycemia chimawonjezeka ndikusintha kwa malo amachitidwe a insulin, kuwonjezereka kwa insulin sensitivity (kuphatikizapo kuthetseratu zochitika zopsinjika), kuchuluka kwa masewera olimbitsa thupi, kuperewera kwa zakudya, kusanza, kutsekula m'mimba, kumwa mowa, matenda osaperekedwa a dongosolo la endocrine, komanso kugwiritsa ntchito mankhwala ena ( onani Kuyanjana ndi Mankhwala Ena).
Odwala omwe ali ndi matenda ashuga ayenera kusamala pakuwongolera njira zomwe zingakhale zopanda chitetezo; kukula kwa hypoglycemia kungayambitse chizungulire komanso kuchepa kwa ndende.

Mimba
Palibe zambiri zamankhwala pakugwiritsa ntchito mankhwalawa Lantus SoloStar mwa amayi apakati. M'maphunziro a nyama, kusowa kwa teratogenic, mutagenic ndi embryotoxic zotsatira za insulin glargine, komanso zovuta zake pakubala komanso kubereka ana, zidawululidwa. Ngati ndi kotheka, Lantus SoloStar akhoza kulembedwa kwa amayi apakati. Mitsempha ya m'magazi a plasma iyenera kuyang'aniridwa mosamala mwa amayi apakati, chifukwa cha kusintha kwa zofunikira za insulin. Mu trimester yoyamba, kufunika kwa insulin kumatha kuchepa, ndipo chachiwiri ndi chachitatu chimayamba kuchuluka.

Pambuyo pobadwa, kufunika kwa insulin kumachepa kwambiri ndipo pamakhala chiwopsezo cha hypoglycemia.

Pa mkaka wa m`mawere, mankhwala Lantus SoloStar itha kugwiritsidwa ntchito pang'onopang'ono kuwunika kwaminyewa ya m'magazi a plasma. Palibe chidziwitso chokhudza kulowa kwa insulin glargine mu mkaka wa m'mawere, koma m'matumbo, insulin glargine imagawanika mu amino acid ndipo sangathe kuvulaza akhanda omwe amayi awo amalandiridwa ndi Lantus SoloStar.

Mogwirizana ndi mankhwala ena:
Kugwiritsa ntchito kwa mankhwala Lantus SoloStar ingasiyane ndi kuphatikiza komwe mumagwiritsidwa ntchito ndi mankhwala ena, makamaka:
Oral antidiabetesic agents, angiotensin otembenuza enzyme inhibitors, monoamine oxidase inhibitors, salicylates, sulfanilamides, fluoxetine, propoxyphene, pentoxifylline, disopyramide ndi fibrate zomwe zingayambitse zotsatira za insulin glargine mukamagwiritsa ntchito limodzi.
Corticosteroids, diuretics, danazole, glucagon, diazoxide, estrogens ndi progestins, isoniazid, sympathomimetics, somatropin, proteinase inhibitors, mahomoni a chithokomiro komanso antipsychotic amachepetsa mphamvu ya hypoglycemic ya mankhwala Lantus SoloStar.
Mchere wa Lithium, clonidine, pentamidine, mowa wa ethyl ndi beta-adrenoreceptor blockers amatha kuyambitsa komanso kuchepetsa hypoglycemic zotsatira za mankhwala Lantus SoloStar.
Lantus SoloStar amachepetsa zovuta za zotsatira za clonidine, reserpine, guanethidine ndi beta-adrenergic blockers.

Bongo
Ndi mankhwala osokoneza bongo a insulin glargine, odwala amakhala ndi hypoglycemia yamitundu yosiyanasiyana. Ndi hypoglycemia yayikulu, kukulitsa khunyu, chikomokere ndi mitsempha ndikutheka.
The chifukwa cha bongo wa mankhwala Lantus SoloStar pakhoza kukhala kusintha kwa dosing (makonzedwe a mlingo wambiri), kudumpha chakudya, kuchuluka kwa thupi, kusanza ndi kutsekula m'mimba, matenda omwe amachepetsa kufunika kwa insulin (kuphatikizapo kuwonongeka kwa impso ndi chiwindi, hypofunction ya pituitary gland, adrenal cortex kapena chithokomiro cha chithokomiro), kusintha malo kuyambitsa kwa mankhwala Lantus SoloStar.

Mitundu yofatsa ya hypoglycemia imakonzedwa ndimakumwa a pakamwa (muyenera kupereka chakudya kwa wodwala kwa nthawi yayitali ndikuwunika momwe alili, popeza Lantus SoloStar ali ndi mphamvu yayitali).
Ndi kwambiri hypoglycemia (kuphatikizapo mawonekedwe a minyewa), makonzedwe a glucagon (subcutaneously kapena intramuscularly) kapena kulowetsedwa kwa mayankho a glucose okhazikika akuwonetsedwa.
Matenda a wodwalayo amayenera kuwunikiridwa kwa maola osachepera a 24, popeza ma epicode a hypoglycemia amatha kubwereranso pambuyo poyimitsa kuukira kwa hypoglycemia ndikuwongolera mkhalidwe wa wodwalayo.

Kutulutsa Fomu:
Yankho la jakisoni Lantus SoloStar 3 ml makatoni olongedza omata mu cholembera chautaya, ma syringe 5 osakhala ndi singano za jakisoni amaikidwa m'bokosi la makatoni.

Malo osungira:
Lantus SoloStar Iyenera kusungidwa osaposa zaka zitatu mutapanga zipinda zomwe kutentha kwanyengo kumayesedwa kuchokera ku 2 mpaka 8 Celsius. Sungani cholembera kuti chisafike kwa ana. Ndi zoletsedwa kumasula yankho Lantus SoloStar.
Mukatha kugwiritsa ntchito koyamba, cholembera cha syringe chitha kugwiritsidwa ntchito kwa masiku osaposa 28. Pambuyo pakuyamba kugwiritsa ntchito, cholembera cha syringe chizisungidwa mzipinda zokhala ndi kutentha kwa 15 mpaka 25 digiri Celsius.

Zopangidwa:
1 ml yankho la jakisoni Lantus SoloStar ili ndi:
Insulin glargine - 3.6378 mg (ofanana ndi magawo zana a insulin glargine),
Zosakaniza zina.