Trajenta - kalasi yatsopano ya mankhwala antidiabetesic

Chaka chachisanu ndi chiwiri, mankhwala abwino kwambiri ochiritsira matenda a shuga adawonekera pamsika, kugwiritsidwa ntchito kwake sikupititsa patsogolo matenda omwe alipo pakatikati pa mtima, impso ndi chiwindi, akatswiri a matenda a shuga adati. "Trazhenta", yomwe idakhazikitsidwa ndi blocker ya enzyme dipeptidyl peptidase-4 linagliptin, amatanthauza othandizira a hypoclycemic. Mankhwala amakhudzana ndi mankhwalawa cholinga chake ndikuchepetsa kuphatikiza kwa glucagon wa mahomoni, komanso kuonjezera kupanga kwa insulin. Gululi la mankhwalawa limadziwika kuti ndi imodzi mwamavuto kwambiri othandizira odwala matenda oopsa - mtundu wachiwiri wa matenda ashuga.

Kodi matenda ashuga ndi chiani?

Uku ndi kuzungulira kwa dongosolo la endocrine, chifukwa chomwe kuchuluka kwa shuga m'magazi a munthuyo kumawonjezeka, chifukwa thupi limalephera kuyamwa insulin. Zotsatira za matendawa ndizovuta kwambiri - njira za metabolic zimalephera, zotengera, ziwalo ndi machitidwe amakhudzidwa. Chimodzi mwa zoopsa komanso zobisika kwambiri ndi matenda ashuga amtundu wachiwiri. Matendawa amatchedwa chiwopsezo chenicheni kwa anthu.

Mwa zina zoyambitsa kufa kwa anthu m'zaka makumi awiri zapitazi, zafika poyamba. Chomwe chimapangitsa kuti matendawa athe kutukuka amaoneka ngati kulephera kwa chitetezo chathupi. Ma antibodies amapangidwa m'thupi lomwe limawonongera maselo a pancreatic. Zotsatira zake, shuga m'magulu ambiri amayendayenda momasuka m'magazi, ndikusokoneza ziwalo ndi machitidwe. Chifukwa cha kusowa bwino, thupi limagwiritsa ntchito mafuta ngati mphamvu, zomwe zimapangitsa kuti pakhale kupangika kwa matupi a ketone, zomwe ndi zinthu zakupha. Zotsatira zake, mitundu yonse ya ma metabolic omwe amachitika mthupi amasokonezeka.

Chifukwa chake, ndikofunikira kwambiri mukapeza matenda kuti musankhe bwino mankhwalawa ndikugwiritsa ntchito mankhwala apamwamba, mwachitsanzo, "Trazhentu", kuwunika kwa madokotala ndi odwala omwe angapezeke pansipa. Kuopsa kwa matenda ashuga ndikuti kwa nthawi yayitali sikungapereke chiwonetsero chazachipatala, ndipo kuwunika kwa shuga wambiri kumapezeka mwa mwayi pakuwunika koyeserera.

Zotsatira za matenda ashuga

Asayansi kuzungulira padziko lonse lapansi akuchita kafukufuku pafupipafupi kuti adziwe njira zatsopano zopangira mankhwala omwe angagonjetse matenda oyipa. Mu 2012, mankhwala apadera adalembetsedwa m'dziko lathu, omwe samayambitsa zotsatira zoyipa komanso amavomerezedwa ndi odwala. Kuphatikiza apo, amaloledwa kuvomereza anthu omwe ali ndi impso komanso kwa chiwindi - monga momwe zalembedwera mu ndemanga ya "Trazhent".

Choopsa chachikulu ndi zovuta zotsatirazi za matenda ashuga:

• kutsika kwamawonedwe owoneka mpaka kutayika kwathunthu,
• kulephera kugwira ntchito kwa impso,
• matenda amitsempha ndi mtima - kulowetsedwa kwa myocardial, atherosulinosis, matenda a mtima a ischemic,
• Matenda a m'mapazi - purulent-necrotic process, zilonda zam'mimba,
• mawonekedwe a zilonda pamimba.
• zotupa pakhungu,
• neuropathy, yomwe imawonetsedwa ndi kupweteka, kupindika komanso kuchepa kwamphamvu kwa khungu,
• chikomokere
• kuphwanya ntchito za m'munsi.

"Trazhenta": Kufotokozera, kapangidwe

Mankhwala amapangidwa mu mawonekedwe a piritsi. Mapiritsi ozungulira a biconvex okhala ndi m'mphepete mwa beve amakhala ndi chipolopolo chofiirira. Kumbali imodzi kuli chizindikiro cha wopanga, chomwe chikuwonetsedwa ngati zolemba, mbali inayo - alphanumeric dzina lake D5.

Zomwe zimagwiritsidwa ntchito ndi linagliptin, chifukwa chogwira ntchito kwambiri pamtundu umodzi, ma milligram asanu ndi okwanira. Gawoli, lomwe limakulitsa kupanga insulin, limachepetsa kaphatikizidwe ka glucagon. Zotsatira zimachitika mphindi zana ndi makumi awiri pambuyo pa kuperekera - ndi pambuyo pa nthawi iyi kuti kuchuluka kwake kwakukulu m'magazi kumawonedwa. Omwe amafunika kupangira mapiritsi:

• magnesium wakuba,
• pregelatinized ndi wowuma chimanga,
• mannitol ndi okodzetsa,
• Copovidone ndimomwe amachokera.

Chipolopolocho chimakhala ndi hypromellose, talc, utoto wofiira (iron oxide), macrogol, titanium dioxide.

Zolemba za mankhwala

Malinga ndi madotolo, "Trazhenta" muzochita zamankhwala yatsimikizira kuti ikugwira ntchito mochiritsira mtundu wachiwiri wa matenda opatsirana a shuga mdziko la makumi asanu, kuphatikiza Russia. Kafukufuku adachitika m'maiko makumi awiri mphambu awiri momwe odwala masauzande amtundu wa shuga adagwira nawo poyesa mankhwalawa.

Chifukwa chakuti mankhwalawa amachotsedwa m'thupi la munthu kudzera m'mimba, osati kudzera mu impso, kuwonongeka mu ntchito yawo, kusintha kwa mankhwalawa sikofunikira. Uku ndikusiyana kwakukulu pakati pa Trazenti ndi othandizira ena odwala matenda ashuga. Ubwino wotsatira ndi motere: wodwalayo alibe hypoglycemia akamwa mapiritsi, onse molumikizana ndi Metformin, komanso monotherapy.

About opanga mankhwalawa

Kupanga kwa mapiritsi a Trazhenta, ndemanga zake zomwe zimapezeka mwaulere, zimachitika ndi makampani awiri azamankhwala.

1. "Eli Lilly" - kwa zaka 85 wakhala m'modzi mwa atsogoleri padziko lonse lapansi popanga zisankho zatsopano zothandiza odwala omwe adwala matenda ashuga. Kampaniyo ikukulitsa mitundu yonse pogwiritsa ntchito kafukufuku waposachedwa.
2. "Beringer Ingelheim" - imatsogolera kuyambira 1885. Amachita kafukufuku, chitukuko, kupanga, komanso kugulitsa mankhwala. Kampaniyi ndi m'modzi mwa atsogoleri makumi awiri padziko lonse lapansi omwe amagulitsa mankhwala.

Kumayambiriro kwa chaka cha 2011, makampani onsewa adasainirana mgwirizano pakulimbana ndi matenda ashuga, chifukwa cha zomwe kupita patsogolo kwakukwaniritsidwa pantchito yodwala matenda opatsirana. Cholinga cha kuyanjanaku ndikuphunzira kuphatikiza kwatsopano kwa mitundu inayi ya mankhwala omwe ali gawo la mankhwala omwe amapangidwa kuti athetse zizindikiro za matendawa.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi ndemanga ndi malangizo ogwiritsira ntchito, "Trazhenta" imalimbikitsidwa kuti igwiritsidwe ntchito pochizira mtundu wachiwiri wa matenda osokoneza bongo omwe ali ndi monotherapy komanso molumikizana ndi othandizira ena a mapiritsi a hypoglycemic, komanso insulin. Poyambirira, adalembera:

• contraindication potenga Metformin kapena kuwonongeka kwa impso,
• osakwanira glycemic kuteteza maziko a maphunziro akuthupi komanso kudya kwapadera.

Ndi kuperewera kwa monotherapy ndi mankhwala otsatirawa, komanso mothandizidwa ndi zakudya komanso masewera olimbitsa thupi, chithandizo chovuta chimasonyezedwa.

1. Ndi zotumphukira za sulfonylurea, Metformin, thiazolidinedione.
2. Ndi insulin kapena Metformin, pioglitazone, sulfonylureas ndi insulin.
3. Ndi Metformin ndi sulfonylurea zotumphukira.

Contraindication

Malinga ndi ndemanga ndi malangizo, "Trazhent" saloledwa kutenga mwana akamadikirira, komanso pakudya kwachilengedwe. M'maphunziro a preclinical, zidapezeka kuti mankhwala othandizira (linagliptin) ndi ma metabolites amadutsa mkaka wa m'mawere. Chifukwa chake, nkosatheka kupatula cholakwika pa mwana wosabadwayo ndi zinyenyeswazi zomwe zili poyamwitsa. Ngati ndizosatheka kuletsa mankhwalawo ndikuisinthanso ndi yofanana, madokotala amalimbikitsa kuti asinthe kuchokera ku chilengedwe kupita pakudya.

Kugwiritsa ntchito mapiritsi kumapangidwa zotsatirazi:

• zaka khumi ndi zisanu ndi zitatu,
• matenda ashuga ketoacidosis,
• mtundu 1 shuga
• kusalolera payekha pazinthu zomwe zimapanga "Trazenti".

Pakuwunika kwa madotolo, komanso malangizo ogwiritsira ntchito mankhwalawa, pali chidziwitso kuti chikuyenera kugwiritsidwa ntchito mosamala kwa anthu azaka zopitilira 700 pamene amamwa mankhwala a insulin komanso (kapena) a sulfonylurea. Kafukufuku wokhudza momwe mankhwalawo amathandizira poyendetsa magalimoto ndi magalimoto sanachitike. Komabe, chifukwa cha kupezeka kwa hypoglycemia, makamaka mukalandira chithandizo chamankhwala, muyenera kusamala. Ngati pancreatitis yachuma yapezeka, mankhwalawo ayenera kusiyidwa. Pankhaniyi, adokotala angasankhe njira ina yothandizira.

Malangizo apadera

Ndikofunika kukumbukira kuti pochiza matenda a ketoacidosis a mtundu 1 matenda a shuga, Trazenti ndi yoletsedwa. Pakuwunika kwa anthu odwala matenda ashuga, chenjezo lotere ndilofala kwambiri. Kuphatikiza apo, zimadziwika kuti chiopsezo cha pathologies a mtima sichikukwera. Anthu omwe ali ndi vuto la chiwindi ndi impso amatha kumwa mankhwalawa muyezo, kusintha kwake sikofunikira.

Mgawo la zaka kuyambira makumi asanu ndi awiri kudza makumi asanu ndi atatu, kugwiritsa ntchito linagliptin kunawonetsa zotsatira zabwino. Kutsika kwakukulu kunawonedwa:

• glycosylated hemoglobin,
• misempha ya plasma pamimba yopanda kanthu.

Kumwa mankhwalawa ndi anthu omwe adutsa zaka makumi asanu ndi atatu akuyenera kuchitika mosamala kwambiri, chifukwa chidziwitso chachipatala ndi gulu ili ndichoperewera.

Zovuta za hypoglycemia ndizochepa kwambiri mukamangotenga "Trazenta" imodzi yokha. Ndemanga za odwala zimatsimikiziranso izi. Kuphatikiza apo, m'm ndemanga zawo, adazindikira kuti kuphatikiza ndi mankhwala ena a shuga, chitukuko cha glycemia sichinyansa. Muzochitika izi, ngati kuli kofunikira, dokotala amatha kuchepetsa mlingo wa insulin kapena zotumphukira za sulfonylurea. Kulandila "Trazhenty" sikuchulukitsa chiopsezo cha matenda a mtima kapena sitiroko, zomwe ndizofunikira mukamamwa mutakula.

Zotsatira zoyipa

Mankhwala ambiri omwe amagwiritsidwa ntchito pochiza matenda osokoneza bongo amatha kudwala matenda am'magazi omwe amachepetsa kwambiri, zomwe zimabweretsa chiopsezo kwa munthu. "Trazhenta", mu ndemanga pomwe amati kuti sizimayambitsa hypoglycemia, ndizosiyana ndi malamulo. Izi zimawerengedwa kuti ndi mwayi wofunika kuposa magulu ena a othandizira a hypoglycemic. Zotsatira zoyipa zomwe zimachitika munthawi ya chithandizo "Trazentoy",:

• kapamba
• kutsokomola kumachitika
• nasopharyngitis,
• Hypersensitivity
• kuchuluka kwa plasma amylase,
• zotupa
• ndi ena.

Ngati mankhwala osokoneza bongo, njira zomwe zimachitika nthawi zonse zimasonyezedwa kuti zimachotsa mankhwala osagwiritsidwa ntchito pakudya chamagaya ndi mankhwala.

"Trazhenta": ndemanga za odwala matenda ashuga ndi akatswiri azachipatala

Kuchita kwakukulu kwa mankhwalawa kwatsimikiziridwa mobwerezabwereza ndi machitidwe azachipatala ndi maphunziro apadziko lonse lapansi. Endocrinologists m'mawu awo amalimbikitsa kugwiritsa ntchito mankhwalawa pophatikizira kapena ngati chithandizo cha mzere woyamba. Ngati munthuyo ali ndi vuto la hypoglycemia, lomwe limapatsa thanzi zakudya zoyenera komanso kuchita masewera olimbitsa thupi, ndikofunika kupatsa "Trazent" m'malo mwa zotumphukira za sulfonylurea. Sizotheka nthawi zonse kuwunika momwe mankhwalawo amathandizira ngati amamwa mankhwala ophatikiza, koma ambiri zotsatira zake zimakhala zabwino, zomwe zimasonyezedwanso ndi odwala. Pali ndemanga zokhudzana ndi mankhwalawa "Trazhenta" pomwe adalimbikitsa kuti kunenepa kwambiri ndi insulin.

Ubwino wa mapiritsi odana ndi matenda ashuga ndiwakuti samathandizira kulemera, samapweteketsa chitukuko cha hypoglycemia, komanso samachulukitsa zovuta za impso. Trazhenta yawonjezera chitetezo, chofunikira kwambiri kwa odwala matenda ashuga. Chifukwa chake, pali ndemanga zabwino zambiri zokhudzana ndi chida chapaderachi. Pakati pa mphindi tawonani mtengo wokwera komanso kusalolera kwa munthu payekha.

Mankhwala a Analog "Trazhenty"

Ndemanga zomwe odwala omwe amamwa mankhwalawa amakhala nazo zimakhala zabwino. Komabe, kwa anthu ena, chifukwa cha hypersensitivity kapena tsankho, madokotala amalimbikitsa mankhwala omwewo. Izi zikuphatikiza:

• "Sitagliptin", "Januvia" - odwala amatenga mankhwalawa monga kuwonjezera pa masewera olimbitsa thupi, kudya, kukonza chiwopsezo cha glycemic, kuphatikiza apo, mankhwalawa amagwiritsidwa ntchito paliponse pochiritsa
• "Alogliptin", "Vipidia" - nthawi zambiri mankhwalawa amalimbikitsidwa pakanapanda zotsatira za zakudya, masewera olimbitsa thupi ndi monotherapy,
• "Saksagliptin" - imapangidwa pansi pa dzina la malonda "Ongliza" pofuna kugwiritsa ntchito mtundu wachiwiri wa matenda osokoneza bongo, amagwiritsidwa ntchito ngati mankhwala a monotherapy komanso mankhwala ena apiritsi ndi inulin.

Kusankhidwa kwa analogue kumachitika kokha ndi chithandizo cha endocrinologist, kusintha kwakokha kwa mankhwala ndizoletsedwa.

Odwala omwe ali ndi vuto la impso

"Mankhwala abwino kwambiri" - mawu ngati awa amayambitsa ndemanga za "Trazhent". Kuda nkhawa kwambiri mukamamwa mankhwala othandizira odwala matenda a shuga kumakhala kumachitika ndi anthu omwe ali ndi vuto la impso, makamaka omwe akudwala hemodialysis. Kubwera kwa mankhwalawa munthaka yamapulogalamu, odwala omwe ali ndi matenda a impso adayamika, ngakhale anali okwera mtengo.

Chifukwa cha zapadera zamankhwala, shuga a m'magazi amachepetsa kwambiri pakumwa mankhwalawa kamodzi kokha patsiku pa mankhwala othandiza mamiligalamu asanu. Ndipo zilibe kanthu nthawi yakumwa mapiritsi. Mankhwalawa amalowa msanga pambuyo polowera m'matumbo am'mimba, kuchuluka kwakukulu kumayang'aniridwa pambuyo pa ola limodzi ndi theka kapena awiri atayikiridwa. Amayikamo ndowe, ndiye kuti impso ndi chiwindi sizitenga nawo mbali m'njira imeneyi.

Pomaliza

Malinga ndi ndemanga za anthu odwala matenda ashuga, Trazhent imatha kutengedwa nthawi iliyonse yabwino, mosasamala za zakudya komanso kamodzi patsiku, zomwe zimatengedwa kuti ndizophatikiza zazikulu. Chokhacho chomwe muyenera kukumbukira: simungathe kumwa kawiri tsiku limodzi. Kuphatikiza chithandizo, mlingo wa "Trazhenty" sukusintha. Kuphatikiza apo, kukonza kwake sikofunikira pa vuto ndi impso. Mapiritsiwo amalekeredwa bwino, zovuta zimachitika kawirikawiri. "Trazhenta", ndemanga zake zomwe ndizokangalika kwambiri, zili ndi chinthu china chake chothandiza kwambiri. Chosafunikira kwenikweni ndichakuti mankhwalawa amaphatikizidwa pamndandanda wazamankhwala omwe amatsalira mumafakitoreti a mankhwala aulere.

Trazhenta - mawonekedwe ndi mawonekedwe

Opanga, BOEHRINGER INGELHEIM PHARMA (Germany) ndi BOEHRINGER INGELHEIM ROXANE (USA), amatulutsa mankhwalawo ngati mapiritsi ofiira owoneka bwino. Kumbali ina kuli chifanizo cholembedwa cha kampani yopanga yomwe imateteza mankhwalawo ku fakes, inayo - chizindikiro "D5".

Iliyonse mwa iwo imakhala ndi 5 mg ya yogwira linagliptin ndi mafilimu osiyanasiyana monga wowuma, utoto, hypromellose, magnesium stearate, Copovidone, macrogol.

Chotumphukira chilichonse cha aluminium chimanyamula mapiritsi 7 kapena 10 a mankhwala a Trazhenta, chithunzi chake chikhoza kuwonedwa m'gawoli. Mu bokosi amatha kukhala osiyana - kuchokera pama mbale awiri mpaka asanu ndi atatu. Ngati chithuacho chili ndi maselo 10 okhala ndi mapiritsi, ndiye kuti m'bokosimo padzakhala mbale zitatu.

Pharmacology

Kuthekera kwa mankhwalawa kumatheka bwino chifukwa cha zoletsa za ntchito ya dipeptidyl peptidase (DPP-4). Enzyme iyi imawononga

pa mahomoni HIP ndi GLP-1, omwe amathandiza kwambiri kuti glucose ikhale bwino. Ma insretins amalimbikitsa kupanga kwa insulin, kuthandizira kuwongolera glycemia, ndikuletsa kubisala kwa glucagon. Zochita zawo zimakhala zakanthawi kochepa; pambuyo pake, HIP ndi GLP-1 imawononga ma enzyme. Trazhenta imagwirizananso ndi DPP-4, izi zimakupatsani mwayi wokhala ndi thanzi la ma impretins komanso kuwonjezera kuchuluka kwa magwiridwe ake.

Mphamvu ya kukopa kwa Trazhenty ndi ofanana ndi mfundo za ntchito za anifanizo ena - Januvius, Galvus, Ongliza. HIP ndi GLP-1 zimapangidwa pamene michere ilowa m'thupi. Kugwiritsa ntchito kwa mankhwala sikugwirizana ndi kukondweretsa kwawo, mankhwalawa amangokulitsa kutalikirana kwawo. Chifukwa cha machitidwe otere, Trazhenta, monga ma incretinomimetics ena, samatulutsa kukondoweza kwa hypoglycemia, ndipo mwayiwu ndiwothandiza kwambiri kuposa magulu ena a mankhwala a hypoglycemic.

Ngati shuga sangachuluke kwambiri, ma insretins amathandizira kupanga insulin ya insulin mwa β-cell. Horoni GLP-1, yomwe ili ndi mndandanda wofunikira kwambiri poyerekeza ndi GUI, imalepheretsa kuphatikiza kwa glucagon m'maselo a chiwindi. Njira zonsezi zimathandizira kukhazikika glycemia pamlingo woyenera - kuchepetsa glycosylated hemoglobin, shuga komanso shuga m'magazi pambuyo pochita masewera olimbitsa thupi kwa maola awiri. Mu zovuta mankhwala a metformin ndi sulfonylurea kukonzekera, glycemic magawo bwino popanda zovuta kuwonda.

Pharmacokinetics

Pambuyo polowa m'matumbo, mankhwalawa amatengeka mwachangu, Cmax imawonedwa pambuyo pa ola limodzi ndi theka. Ndendeyi imachepera m'magawo awiri.

Kugwiritsa ntchito mapiritsi ndi chakudya kapena padera pa pharmacokinetics yamankhwala sikukhudza. The bioavailability wa mankhwala mpaka 30%. Peresenti yaying'ono imapangidwa, 5% imakumbidwa ndi impso, 85% yochotsa ndowe. Matenda aliwonse a impso safuna kuti munthu atenge mankhwala kapena kusintha kwa mankhwala. Zolemba za pharmacokinetics muubwana sizinaphunzire.

Kodi mankhwala a ndani

Trazent imasankhidwa ngati mankhwala mzere woyamba kapena kuphatikiza ndimankhwala ena ochepetsa shuga.

1. Monotherapy. Ngati wodwala matenda ashuga samalola kugwiritsa ntchito mankhwala osokoneza bongo a mitundu yayikulu monga metformin (mwachitsanzo, ndi aimpso kapena kusalolera kwa ziwalo zake), ndikusintha kwamachitidwe sikubweretsa zotsatira zomwe mukufuna.
2. Zigawo ziwiri. Trazent imayikidwa limodzi ndi sulfonylurea kukonzekera, metformin, thiazolidatediones. Ngati wodwala ali ndi insulin, incretinomimetic ikhoza kuwonjezeranso.
3. Njira zitatu. Ngati chithandizo cham'mbuyomu cha mankhwala othandizira sichigwira ntchito mokwanira, Trazhenta imaphatikizidwa ndi insulin ndi mtundu wina wa mankhwala antidiabetic omwe ali ndi njira ina yochitira.

Yemwe sanapatsidwe Trazhent

Linagliptin amatsutsana chifukwa cha matenda ashuga:

• Mtundu woyamba wa shuga
• Ketoacidosis wakwiyitsidwa ndi matenda ashuga,
• Amimba komanso kuyatsa
• Ana ndi unyamata
• Hypersensitivity pazomwe zimapangidwira.

Zotsatira zoyipa

Pa maziko akutenga linagliptin, zotsatira zoyipa zimayamba:

• Nasopharyngitis (matenda opatsirana)
• Kutsokomola
• Hypersensitivity
• Pancreatitis
• Kuwonjezeka kwa triglycerol (akaphatikizidwa ndi mankhwala a gulu la sulfonylurea),
• Kuchulukitsa kwama LDL (mothandizidwa ndi pioglitazone),
• Kukula kwa thupi
• Zizindikiro za Hypoglycemic (motsutsana ndi maziko a mankhwala awiri komanso atatu).

Pafupipafupi komanso kuchuluka kwa zovuta zomwe zimachitika mutatha kudya Trazhenta ndizofanana ndi kuchuluka kwa zovuta pambuyo pogwiritsa ntchito placebo. Nthawi zambiri, zotsatira zoyipa zimachitika ndi maulendo atatu a Trazhenta omwe ali ndi metformin komanso sulfonylurea.

Mankhwalawa amatha kuyambitsa zovuta kumalumikizana, ndikofunikira kuganizira izi mukamayendetsa magalimoto ndi magwiridwe antchito.

Bongo

Ophunzira adapatsidwa mapiritsi a 120 (600 mg) panthawi imodzi. Mankhwala osokoneza bongo amodzi sanakhudze thanzi la odzipereka ochokera ku gulu loyendetsa bwino. Pakati pa odwala matenda ashuga, milandu ya overdose sinalembedwe ndi ziwerengero zamankhwala. Ndipo komabe, ngati pakuchitika mwangozi kapena mwanjira inayake ma Mlingo angapo nthawi imodzi, wovutitsidwayo amayenera kutsuka m'mimba ndi matumbo kuti achotse gawo losasakanizika la mankhwalawo, apatseni ma sorbets ndi mankhwala ena molingana ndi zizindikirazo, onetsani adotolo.

Momwe mungamwe mankhwalawa

Malinga ndi malangizo ogwiritsa ntchito, matendawa amayenera kumwa mapiritsi 1 (5 mg) katatu patsiku. Ngati mankhwalawa agwiritsidwa ntchito pazovuta zovuta limodzi ndi metformin, ndiye kuti mankhwalawa amasungidwa.

Anthu odwala matenda ashuga aimpso kapena a hepatic osakwanira safuna kusintha kwa mlingo. Zizolowezi sizosiyana kwa odwala azaka zokhwima. Mu senile (wazaka 80), Trazhenta sanatchulidwe chifukwa cha kusowa kwa chidziwitso m'chipani cha m'badwo uno.

Ngati nthawi yakumwa mankhwalawo yakusowa, muyenera kumwa piritsi mwachangu. Ndikosatheka kubwereza zomwezo. Kugwiritsa ntchito mankhwalawa sikugwirizana ndi nthawi yakudya.

Mphamvu ya trazhenti pa mimba ndi mkaka wa m`mawere

Zotsatira zakugwiritsa ntchito mankhwalawa ndi amayi apakati sizofalitsidwa. Pakadali pano, kafukufuku wachitika pa nyama zokhazokha, ndipo palibe zolemba za poizoni zomwe zalembedwa. Ndipo komabe, panthawi yoyembekezera, azimayi sapatsidwa mankhwala.

Poyeserera nyama, zidapezeka kuti mankhwalawo amatha kulowa mkaka wa mayi. Chifukwa chake, nthawi yakudya, azimayi sanapatsidwe Trazhent. Ngati boma laumoyo likufuna mankhwala otere, mwana amamuthandizira zakudya zopanda pake.

Kafukufuku wazokhudza mphamvu ya mankhwala pakubala mwana sanatengeke. Kuyesera komweko pa nyama sikunawonetse vuto lililonse mbali iyi.

Kuyanjana kwa mankhwala osokoneza bongo

Kugwiritsa ntchito munthawi yomweyo kwa Trazhenta ndi Metformin, ngakhale mlingo utakhala wokwera kuposa muyezo, sizinayambitse kusiyana kwakukulu mu pharmacokinetics yamankhwala.

Kugwiritsa ntchito pamodzi kwa Pioglitazone sikusinthanso mphamvu ya pharmacokinetic ya mankhwala onse awiri.

Chithandizo chovuta ndi Glibenclamide sichowopsa kwa Trazhenta, chifukwa chomaliza, Cmax chimachepera pang'ono (ndi 14%).

Zotsatira zofananazo zimawonetsedwa ndi mankhwala ena a gulu la sulfonylurea.

Kuphatikiza kwa ritonavir + linagliptin kumachulukitsa Cmax katatu, kusintha kotereku sikutanthauza kusintha kwa mlingo.

Kuphatikiza ndi Rifampicin kumapangitsa kuchepa kwa Cmax Trazenti. Mwapang'onopang'ono, mawonekedwe azachipatala amasungidwa, koma mankhwalawa sagwira ntchito 100%.

Siowopsa kuyika Digoxin nthawi yomweyo ngati lynagliptin: ma pharmacokinetics a mankhwala onsewa sasintha.

Trazhent sichikhudza kuthekera kwa Varfavin.

Kusintha kocheperako kumawonedwa limodzi ndi kugwiritsidwa ntchito kwa linagliptin ndi simvastatin, koma mlingidwe wa incretin samakhudza kwambiri mawonekedwe ake.

Poyerekeza ndi chithandizo cha mankhwala ndi Trazhenta, njira zakulera za pakamwa zitha kugwiritsidwa ntchito momasuka.

Malangizo owonjezera

Matendawa satchulidwa mtundu 1 wa shuga komanso ketoacidosis, vuto la matenda ashuga.

Chiwopsezo cha zochitika za hypoglycemic pambuyo pa chithandizo cha linagliptin, chogwiritsidwa ntchito ngati monotherapy, ndizokwanira kuchuluka kwa milandu yotere ndi placebo.

Kuyesa kwa zamankhwala kwawonetsa kuti pafupipafupi momwe zimachitika mu hypoglycemia mukamagwiritsa ntchito Trezhenta pophatikiza chithandizo sichimaganiziridwa, popeza kuti vutoli silimayambitsidwa ndi linagliptin, koma ndi metformin ndi mankhwala a gulu la thiazolidinedione.

Chenjezo liyenera kuchitika popereka mankhwala a Trazhenta osakanikirana ndi mankhwala a gulu la sulfonylurea, chifukwa ndi omwe amayambitsa hypoglycemia. Pangozi yayikulu, ndikofunikira kusintha mlingo wa mankhwala a gulu la sulfonylurea.

Linagliptin sikukhudza mwayi wopanga matenda a mtima ndi mtsempha wamagazi.

Kuphatikiza mankhwala, Trazhent angagwiritsidwe ntchito ngakhale kwambiri mkhutu aimpso ntchito.

Odwala achikulire (zaka zopitilira 70), chithandizo cha Trezenta chinawonetsa zotsatira zabwino za HbA1c: hemoglobin yoyambirira inali 7.8%, yomaliza - 7.2%.

Mankhwalawa samatulutsa chiwopsezo cha mtima. Malo oyambira omwe amakhala ndi pafupipafupi komanso nthawi yomwe amwalira, matenda a mtima, sitiroko, osakhazikika a angina pectoris omwe amafunikira kuchipatala, odwala matenda ashuga omwe amatenga linagliptin sanali kawirikawiri komanso mochedwa kuposa odzipereka pagulu lolamulira omwe adalandira mankhwala a placebo kapena kuyerekezera.

Nthawi zina, kugwiritsa ntchito linagliptin kumayambitsa kupweteka kwa pachimake kapamba.

Ngati pali zizindikiro (zopweteka kwambiri za epigastrium, vuto la kusowa kwa magazi, kufooka kwathunthu), mankhwalawa ayenera kuyimitsidwa ndikufunsani dokotala.

Kafukufuku wokhudzana ndi kufalikira kwa Trazhenta pa luso loyendetsa magalimoto ndi magwiridwe antchito ambiri sanayendetsedwe, koma chifukwa cha kulumikizidwa komwe kungatheke, imwani mankhwalawo ngati pakufunika, mwachidwi kwambiri komanso mosamala.

Analogs ndi mtengo wamankhwala

Kwa Trazhenta wa mankhwala, mtengo wake umachokera ku ruble 1500-1800 pa mapiritsi 30 ndi mlingo wa 5 mg. Mankhwala omwe mumalandira amamasulidwa.

Zofanizira za gulu lomwelo la DPP-4 zoletsa zimaphatikizapo Januvia zozikidwa pa sinagliptin, Ongliz zochokera ku saxagliptin ndi Galvus wokhala ndi vildagliptin yogwira gawo. Mankhwalawa amafanana ndi code ya ATX Level 4.

Zofanana ndi izi zimaperekedwa ndi mankhwalawa Sitagliptin, Alogliptin, Saksagliptin, Vildagliptin.

Palibe zofunikira zina pakusungidwa kwa Trazenti m'malangizo. Kwa zaka zitatu (malinga ndi nthawi yomwe ntchito yake imatha), mapiritsiwa amasungidwa kutentha kwa firiji (mpaka +25 degrees) m'malo amdima osapeza ana. Mankhwala omwe atha ntchito sangathe kugwiritsidwa ntchito, ayenera kutayidwa.

Anthu odwala matenda ashuga komanso madokotala za Trazhent

Kuchita bwino kwambiri Trazhenty mumitundu yosiyanasiyana yotsimikiziridwa ndi maphunziro apadziko lonse lapansi ndi machitidwe azachipatala. Endocrinologists amakonda kugwiritsa ntchito linagliptin ngati mankhwala a mzere woyamba kapena kuphatikiza pamodzi. Ndi chizolowezi cha hypoglycemia (masewera olimbitsa thupi, kusowa zakudya m'thupi), m'malo mwa mankhwala a sulfonylurea, amapatsidwa mankhwala a Trazhent, pali ndemanga za mankhwala omwe amapezeka chifukwa cha kukana insulini komanso kunenepa kwambiri. Anthu ambiri omwe ali ndi matenda ashuga amalandila mankhwalawa monga mbali ya chithandizo chovuta, kotero ndikovuta kuyesa momwe zimagwirira ntchito, koma pazonse, aliyense ali wokondwa ndizotsatira zake.

Ma Dhib-4 ma inhibitors, omwe Trazhenta ndi ake, amasiyanitsidwa osati ndi mphamvu ya antidiabetes, komanso ndi chiwopsezo chowonjezeka, popeza samatsitsa zotsatira za hypoglycemic, samathandizira pakukula, ndipo samachulukitsa kufooka kwa impso. Mpaka pano, gululi la mankhwala limawerengedwa kuti ndi imodzi mwakulimbikitsa kwambiri pa matenda a shuga.