Mndandanda wa mapiritsi a Januvius

Januvia ndi m'gulu la ma insretins (mahomoni omwe amachititsa mapangidwe a insulin atatha kudya). Ngati Mlingo wa mankhwalawo umathandizira mwachilengedwe, ndiye kuti mankhwalawo samathandizira kupanga ma enzyme a DPP-8.

Januvia amathandizira kutseka zomwe DPP-4 ikuchita. Mankhwala amawonjezera kuchuluka kwa ma insretins ndipo amatsogolera kuntchito yawo. Kupanga kwa insulin m'maselo a pancreatic beta kumathandizidwanso.

Mankhwala amachita izi:

• Kuchepetsa kuchuluka kwa hemoglobin wa glycated.
• Amachotsa kuchuluka kwamafuta m'magazi.
• Zimathandizira kuchepetsa thupi la wodwalayo.

Mkhalidwe wa pharmacokinetic wa mankhwalawa umasiyanasiyana mwa anthu omwe ali ndi matenda ashuga.

Mphamvu yogwira ya mankhwala ndi sitagliptin. Kumwirira kumachitika patatha maola ochepa mutamwa mankhwalawa. Mankhwalawa amasintha ma cell ndi mapuloteni a plasma. Zambiri zomwe zimagwiritsidwa ntchito zimachotsedwa m'thupi popanda kusinthidwa ndi aimpso, ndikupanga katulutsidwe.

Mankhwalawa amagwiritsidwa ntchito ndi odwala omwe sanalandire chokwanira kuchokera pazakudya ndi zochitika zolimbitsa thupi, ngati kugwiritsa ntchito metformin sikuloledwa chifukwa chokana thupi.

Januvia akhoza kuthandizidwa kulandira chithandizo pamodzi ndi metformin ndi ma receptors omwe amathandizidwa ndi peroxisome proliferators, pakalibe zotsatira zabwino pakutsatira chithandizo chamankhwala ndi zolimbitsa thupi.

Mankhwala angagwiritsidwe ntchito katatu. Kuphatikiza pa iye, mankhwala ena awiri omwe ali ndi algorithm ofanana amathandizidwa ndi mankhwalawa. Chithandizo chamtunduwu chimagwiritsidwa ntchito ngati mawonekedwe amitundu iwiri samayang'aniridwa.

Mankhwalawa amatha kugwiritsidwa ntchito limodzi ndi mankhwala a insulin ngati sanawonetse zotsatira zake zokha.

Kafukufuku wokhudzana ndi mtundu wa mankhwalawa kwa ana osakwana zaka 18 sanachitike. Kugwiritsa ntchito sikuloledwa, mankhwalawa ayenera kusinthidwa ndi insulin.

Malangizo ogwiritsira ntchito

Mankhwala amatengedwa kokha ndi pakamwa. Itha kugwiritsidwa ntchito ngati gawo la mankhwala osakaniza.

Mankhwalawa amatengedwa mosasamala nthawi yakudya. Wodwala akaphonya mankhwalawo, ndiye kuti iyenera kumwedwa yomweyo. Ndi zoletsedwa kumwa kawiri Mlingo wa mankhwalawa.

Makamaka chidwi chake chiyenera kulipira pakulimbana kwa mankhwalawa ndi mankhwala ena. The yogwira mankhwala sitagliptin sichikhudza metformin ndi kulera kwapakamwa. Komanso sizichedwetsa mayendedwe a cytochrome enzyme. Ngati tilingalira zoyeserera ndi kugwiritsa ntchito mankhwalawa kunja kwachinthu chamoyo, ndiye kuti sizimachepetsa ma metabol metabolites.

Mukamagwiritsa ntchito mankhwalawa ndi digoxin, chizindikiro cha kuchuluka kwa matanthauzidwe a ROC pamapindikira imakulirakulira. Izi sizikhudza moyo wa munthu. Palibe kusintha kwa mlingo uliwonse wa mankhwalawa.

Mukamagwiritsa ntchito mankhwalawa limodzi ndi cyclosporine, chizindikiro cha kutanthauzira kochulukirapo kwa mawonekedwe a ROC amapitilira. Kafukufuku akuwonetsa kuti kusintha kumeneku sikofunikira. Palibe kusintha kwa njira yogwiritsira ntchito mankhwala iliyonse yomwe ikufunika.

Contraindication

Malangizo a Januvia ogwiritsira ntchito akuwonetsa zotsutsana zotsatirazi:

• Hypersensitivity pazinthu zilizonse zomwe zili ndi mankhwalawa.
• Kuchepetsa kagayidwe kazakudya chifukwa chosakwanira insulin.
• Nthawi yakubala kwa mwana wosabadwayo.
• Nthawi yodyetsa mwana mkaka wamawere.
• Ana a misinkhu yaying'ono. Palibe maphunziro omwe adachitidwira gulu ili la anthu.

Mankhwalawa ayenera kugwiritsidwa ntchito mosamala kwa anthu omwe akudwala matenda a impso komanso kulephera kwa impso. Ndi kukula kwambiri kwa matenda amenewa, ndikofunikira kusintha mlingo wa mankhwalawa.

Kugwiritsa ntchito mankhwalawa kuyenera kuyamba ndi mlingo wofanana ndi 0,1 g yogwira ntchito.

Kusintha kwa manambala sikofunikira mukamagwiritsa ntchito mankhwala ndi metformin.

Mlingo ungasinthidwe ngati mankhwalawo amagwiritsidwa ntchito limodzi ndi insulin. Izi ndikuchepetsa mwayi wa hypoglycemia.

Ngati wodwala akudwala aimpso kulephera kwa mtundu wofatsa, ndiye kuti kusintha kwa mlingo sikofunikira.

Kwa anthu omwe ali ndi vuto la aimpso lokwanira, komanso matenda ena a impso, amafunika kumwa 0,05 g wa mankhwalawa.

A kwambiri aimpso kulephera ndi zina aimpso pathologies, ndikofunikira kuchepetsa mlingo mpaka 0,025 ga yogwira mankhwala tsiku lililonse.

Kwa anthu omwe akuvutika ndi vuto la chiwindi, sikofunikira kusintha mlingo wa mankhwalawo. Kafukufuku wa odwala omwe ali ndi vuto lalikulu laimpso sanachitike.

Zotsatira zoyipa

Ganizirani zovuta za sitagliptin:

• Mavuto a metabolism. Hypoglycemia.
• Ululu m'mutu.
• Mavuto mu minofu ya mafupa a munthu. Ma syndromes opweteka.
• Chizungulire.
• Kudzimbidwa
• Kutsegula m'mimba
• Kusanza ndi kusanza.

Zotsatira zoyipa zimapezekanso ndi kugwiritsidwa ntchito nthawi imodzi kwa sitagliptin ndi metformin / insulin:

• Hypoglycemia.
• Mafuta ochulukirapo m'matumbo.
• Matulo.
• Kudzimbidwa
• Kutsegula m'mimba

Mankhwala amavomerezeka ndi odwala. Zotsatira zoyipa ndizosowa.

Mankhwalawa ndi okwera mtengo. Itha kugulidwa pamtengo wa 1500 mpaka 2000 rubles. mapiritsi 28 a 100 mg yogwira ntchito.

Ganizirani za anzanu a Januvius:

• Avandamet. Muli metformin ndi rosiglitazone. Itha kugwiritsidwa ntchito ngati gawo la mankhwala osakanikirana ndi insulin ndi mankhwala ena a hypoglycemic. Odwala mu amayi apakati ndi ana. Pezani muma pharmacies samapezeka nthawi zonse, mtengo wamba ndi ma ruble 2400.
• Avandia Ndi mankhwala omwe mumalandira. Amachepetsa shuga mumagazi, kumawonjezera chidwi cha mafuta m'thupi. Kuchulukitsa kuchuluka kwa metabolic mthupi. Amapezeka ku malo ogulitsa mankhwala ma ruble 1,500.
• Arfazetin. Imakhala ndi hypoglycemic, imachepetsa shuga. Pafupifupi palibe mavuto. Sili yoyenera kuthandizira odwala matenda ashuga, ndikofunikira kugwiritsa ntchito ngati gawo la mankhwala osakanikirana. Arfazetin ndi wotsika mtengo kuposa mankhwala ena amtunduwu. Mtengo - ma ruble 81.
• Bagomet. Amagwiritsidwa ntchito ngati zakudya ndi zolimbitsa thupi sizinabweretse zotsatira zomwe mukufuna. Mayendedwe ogwiritsira ntchito amaletsa kugwiritsa ntchito mankhwalawa panthawi yapakati komanso mkaka wa m`mawere. Pochiza, ndikofunikira kupewa zakumwa zoledzeretsa ndi mankhwala omwe amakhala ndi ethanol. Mutha kugula ma ruble 332.
• Victoza. Mankhwala okwera mtengo kwambiri. Muli yogwira liraglutide. Kugulitsa ngati yankho la jakisoni. Mutha kugula ma ruble a 10700.
• Galvus. Muli yogwira mankhwala vildagliptin. Zomwe zimawonjezera chidwi cha maselo a beta ku glucose, zomwe zimapangitsa kupanga insulin. Amagwiritsidwa ntchito ngati zochitika zolimbitsa thupi komanso zakudya sizinaphule kanthu. Itha kugwiritsidwa ntchito ngati gawo la mankhwala ophatikiza. Mtengo - 842 rub.
• Galvus Met. Chimodzimodzi ndi mankhwala akale. Amasiyana pakakhala metformin pakapangidwe kake. Itha kugulidwa kwa ma ruble 1500.
• Galvus. Amasintha kayendedwe ka glycemic, amathandizira kuwonjezera kagayidwe. Galvus kapena Galvus? Nthawi zambiri amafunsidwa omwe ali bwino. Mankhwala oyamba ndi otsika mtengo, koma ovuta kuwapeza m'mafakisi. Mtengo - 1257 rub.
• Kutalika kwa Glformin. Amachepetsa gluconeogeneis mu chiwindi. Kuchulukitsa kumverera kwa minofu. Zosintha pakumasulidwa kwakukulu kwa zinthu zogwira ntchito. Itha kugulika ma ruble 244.
• Glucophage. Muli ndi yogwira ntchito metformin. Ndi kudya, kulemera kumachepetsedwa chifukwa cha kuchuluka kwa kagayidwe. Zitha kutengedwa ndi ana patatha zaka 10. Contraindified mu amayi apakati komanso mkaka wa m`mawere. Mutha kugula ma ruble 193.
• Metformin. Imathandizira njira yosinthira glucose kukhala glycogen. Pafupifupi palibe kulumikizana ndi mapuloteni a plasma. Panthawi yamankhwala, ndikofunikira kuyang'anira momwe impso zilili. Mtengo - 103 ma ruble.
• Janumet. Muli yogwira zosakaniza sitagliptin ndi metformin. Ntchito kuphatikiza mankhwala. Mtengo - 2922 rub.

Zofananira zonse za mankhwalawa ziyenera kugwiritsidwa ntchito mosamala, ali ndi mitundu yosiyanasiyana. Musanasinthe mankhwalawa, muyenera kufunsa katswiri.

Bongo

Kafukufuku wachitika momwe mlingo wathanzi wa 0.8 g unaperekedwa kwa odzipereka athanzi. Palibe kusintha kwakukulu pazowonetsa zamankhwala komwe kunawonedwa. Kafukufuku wokhala ndi mlingo woposa 0,8 ga sanachitike.

Ngati zizindikiro zosiyanasiyana zikuwoneka, ndiye kuti chithandizocho chimadalira. Sitagliptin sawonetsedwa bwino ndi dialysis.

Ganizirani malingaliro omwe anthu amasiya okhudzana ndi mankhwalawa:

Ndemanga zikusonyeza kuti mankhwalawa ndi njira yabwino yochizira matenda ashuga. Zotsatira zoyipa zimachitika, koma chokani.

Mankhwalawa ndi mwayi wabwino kusintha shuga m'magazi. Gwiritsani ntchito mankhwalawa mosamala, mutakumana ndi katswiri.

Zilipo m'malo mwa Januvia

Analogue ndiotsika mtengo kuchokera ku 1418 rubles.

Galvus ndi amodzi mwa otsika mtengo kwambiri a Januvia mu mawonekedwe a piritsi. Amagwiritsidwanso ntchito pochiza matenda am'mimba a shuga 2, koma vildagliptin mu 50 mg amagwiritsidwa ntchito pano ngati chinthu chogwira ntchito. pa piritsi limodzi. Pali zoletsa zazaka komanso zoponderezedwa.

Analogue ndiotsika mtengo kuchokera ku ma ruble 561.

Transgenta ndi mankhwala a hypoglycemic aku Austria kuti agwiritse ntchito mkati, kutengera kugwiritsa ntchito linagliptin ngati gawo logwira ntchito. Amagwiritsidwa ntchito pochiza matenda amitundu iwiri ngati mitundu yosiyanasiyana ya mankhwala.

Analogue ndiotsika mtengo kuchokera ku ma ruble 437.

Onglisa ndi mankhwala ena a matenda ashuga ku United States. Pano, chinthu chinanso chogwiritsidwa ntchito chimagwiritsidwanso ntchito (saxagliptin 2.5 mg, 5 mg), motero, kuthandizira kwa mankhwalawa kumatha kutsika ndipo kuyenera kutsimikiziridwa ndi adokotala. Kugwiritsidwa ntchito mosamala pakukanika kwa impso komanso kukalamba.