Insulin NovoRapid: malangizo, ntchito, mankhwala

Njira yothetsera utsogoleri wa sc / iv ndi yowonekera, yopanda utoto.

PRING glycerol - 16 mg, phenol - 1.5 mg, metacresol - 1.72 mg, nthaka ya zinc. - 19.6 mg, sodium kolorayidi - 0.58 mg, sodium hydrogen phosphate dihydrate - 1,25 mg, sodium hydroxide 2M - pafupifupi 2.2 mg, hydrochloric acid 2M - pafupifupi 1,7 mg madzi d / i - mpaka 1 ml.

3 ml (300 PIECES) - makatoni am'magalasi (1) - zolembera zowerengeka zamankhwala angapo a jakisoni angapo (5) - mapaketi a makatoni.

Njira yothetsera utsogoleri wa sc / iv ndi yowonekera, yopanda utoto.

PRING glycerol - 16 mg, phenol - 1.5 mg, metacresol - 1.72 mg, nthaka ya zinc. - 19.6 mg, sodium kolorayidi - 0.58 mg, sodium hydrogen phosphate dihydrate - 1,25 mg, sodium hydroxide 2M - pafupifupi 2.2 mg, hydrochloric acid 2M - pafupifupi 1,7 mg madzi d / i - mpaka 1 ml.

3 ml (300 PIECES) - makatoni am'magalasi (1) - zolembera zowerengeka zamankhwala angapo a jakisoni angapo (5) - mapaketi a makatoni.

Zotsatira za pharmacological

Mankhwala osokoneza bongo a hypoglycemic, analogue of human-temporary insulin, opangidwa ndi recopinant DNA biotechnology pogwiritsa ntchito Saccharomyces cerevisiae strain momwe amino acid proline m'malo a B28 m'malo mwake ndi aspartic acid.

Imalumikizana ndi cholandirira chapadera pa cell ya cytoplasmic maselo ndikupanga insulini-receptor zovuta zomwe zimapangitsanso njira zina, kuphatikizapo kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthetase). Kutsika kwa shuga m'magazi kumachitika chifukwa cha kuchuluka kwa kayendedwe ka intracellular, kuchuluka kwa zotupa, kukondoweza kwa lipogenesis, glycogenogeneis, ndi kuchepa kwa kuchuluka kwa shuga ndi chiwindi.

Kulowetsedwa kwa amino acid proline pamalo a B28 okhala ndi spartic acid mu insulin aspart kumachepetsa chizolowezi cha mamolekyulu kupanga hexamers, yomwe imawonedwa mu yankho la insulin wamba. Motere, insulin aspart imatengedwa mwachangu kuchokera kumafuta amkati ndipo imayamba kuchita zinthu mwachangu kuposa insulin yamunthu. Insulin aspart amachepetsa shuga m'magazi 4 koyamba pambuyo chakudya asanapezeke insulin yaumunthu.

Kutalika kwa nthawi ya insulin aspart pambuyo pa sc makonzedwe amafupikirako kuposa omwe sungunuka wa insulin.

Pambuyo pa utsogoleri wa sc, mphamvu ya mankhwalawa imayamba pakadutsa mphindi 10 mpaka 10 pambuyo pa kutsata. Kuchuluka kwake kumawonedwa patatha maola atatu jekeseni. Kutalika kwa mankhwalawa ndi maola 3-5.

Zoyesa zamankhwala zokhudzana ndi odwala omwe ali ndi matenda amtundu wa 1 asonyeza kuti ali ndi mwayi wochepetsedwa ndi hypoglycemia yausiku. Chiwopsezo cha masana hypoglycemia sichinachuluke kwambiri.

Insulin aspart ndi equipotential sungunuka wa munthu insulin kutengera kuyamwa kwake.

M'maphunziro azachipatala okhudza odwala akuluakulu omwe ali ndi matenda a shuga 1, amawonetsedwa kuti ndi makonzedwe a insulin, mashuga am'magazi am'mimba amawonedwa poyerekeza ndi insulin ya insulin.

Kafukufuku wopangidwa mosiyanasiyana, wakhungu lambiri, wophatikizidwa, adachitidwa ndi pharmacokinetics ndi pharmacodynamics of insulin aspart ndi soluble insulin ya anthu odwala okalamba omwe ali ndi mtundu wa 2 matenda a shuga (19 odwala zaka 65-83 zaka, amatanthauza zaka 70). Kusiyana kwazomwe zimachitika mu pharmacodynamic katundu pakati pa insulin aspart ndi insulle ya insulin ya anthu odwala okalamba anali ofanana ndi odzipereka athanzi komanso odwala achinyamata omwe ali ndi matenda osokoneza bongo.

Mukamagwiritsa ntchito insulin mu ana ndi achinyamata, zotsatira zofananazi zimawonetsedwa pakuwonetsetsa kuchuluka kwa shuga poyerekeza ndi insulle yamunthu.Kafukufuku wazachipatala yemwe amagwiritsa ntchito insulin ya anthu osungunuka musanadye komanso insulin aspart atatha kudya ana omwe ali ndi zaka 2 mpaka 6 (odwala 26), ndipo kafukufuku wofanana wa mankhwala a pharmacokinetic / pharmacodynamic adachitika mwa ana 6-12 zaka ndi achinyamata azaka 13-17. Mbiri ya pharmacodynamic ya insulin aspart mwa ana inali yofanana ndi ya akuluakulu.

Kafukufuku wachipatala wokhudzana ndi chitetezo chokwanira komanso mphamvu ya insulin aspart ndi insulin ya anthu pochiza amayi apakati omwe ali ndi matenda a shuga 1: 322 odwala: 157 adalandira insulini, 165 alandila insulini) sanawonetse zotsatira zoyipa za insulin pa mimba kapena thanzi la fetal / mwana watsopano. Kafukufuku wowonjezera wa azimayi 27 omwe ali ndi gestational shuga mellitus omwe adalandira insulin aspart (odwala 14) ndi insulin ya anthu (13 odwala) adawonetsa kuyesana kwa mbiri ya chitetezo komanso kusintha kwakukulu pakulandila kwa glucose wa postprandial ndi chithandizo cha insulin.

Pharmacokinetics

Pambuyo sc phukusi la insulin, katsabola T max mu plasma ndi 2 peresenti zosakwana pambuyo oyambitsa sungunuka wa munthu insulin. C max m'magazi a plasma okwanira 492 ± 256 pmol / L ndipo amakwaniritsidwa mphindi 40 pambuyo pa s / c pakanatenga 0,15 U / kg kulemera kwa odwala omwe ali ndi matenda a shuga 1. The kuchuluka kwa insulin kubwerera ku chiyambi chake pambuyo maola 4-6 pambuyo makonzedwe a mankhwala. Kuchuluka kwa mayamwidwe kumakhala kotsika mwa odwala omwe ali ndi mtundu wa matenda a shuga 2, omwe amatsogolera kutsika C max (352 ± 240 pmol / L) kenako T max (60 min). Kusintha kwapakati pa T max kumatsika kwambiri pakugwiritsa ntchito insulini aspart poyerekeza ndi insulle yamunthu insulin, pomwe kusinthika kotsimikizika mu mtengo wa C max kwa insulin aspart ndikokulira.

Pharmacokinetics mu milandu yapadera yamankhwala

Ana (wazaka 6 mpaka 12) ndi achinyamata (azaka 13 mpaka 17) omwe ali ndi vuto la matenda ashuga 1: kunyowetsa kwa insulini kumachitika msanga m'magulu onse aanthu a T max ofanana ndi akuluakulu. Komabe, pali zosiyana ndi max m'misinkhu iwiri, zomwe zimagogomezera kufunikira kwa kuchuluka kwa mankhwalawa.

Okalamba: kusiyana kwapakati pa pharmacokinetics pakati pa insulin aspart ndi soluble insulin ya anthu odwala okalamba (zaka 65-83, zaka zapakati pa 70 zaka) zamtundu wa 2 wodwala matenda ashuga anali ofanana ndi odzipereka athanzi komanso odwala achinyamata omwe ali ndi matenda a shuga. Mwa odwala okalamba, kuchepa kwa mayamwidwe kunawonedwa, komwe kunayambitsa kutsika kwa T max (82 (kusiyanasiyana: 60-120 min), pomwe C max anali ofanana ndi omwe amawerengedwa mwa odwala ang'onoang'ono omwe ali ndi matenda a shuga a 2 komanso ochepera pang'ono poyerekeza ndi odwala mtundu 1 shuga.

Kuperewera kwa chiwindi: kafukufuku wa pharmacokinetics adachitika ndi limodzi mlingo wa aspart insulin mwa odwala 24 omwe chiwindi chawo chimagwira kuchokera pakulakwitsa kwambiri. Mwa anthu omwe ali ndi vuto la chiwindi, kuchuluka kwa mayankho a insulin kunachepetsedwa komanso kusinthasintha, zomwe zimapangitsa kutsika kwa mphindi 50 mwa anthu omwe ali ndi chiwindi chokwanira mpaka pafupifupi mphindi 85 mwa anthu omwe ali ndi vuto la chiwindi chokwanira komanso mwamphamvu. AUC, C max ndi chilolezo chokwanira cha mankhwalawo chinali chofanana kwa anthu omwe amachepetsa komanso amakhala ngati chiwindi chimagwira.

Kulephera kwamkati: Kafukufuku adachitika mu pharmacokinetics of insulin aspart mwa odwala 18 omwe ntchito yawo yaimpso imachokera pachizolowezi mpaka kuwonongeka kwambiri. Palibe zotsatira zoonekeratu za kulengedwa kwa creatinine pa AUC, C max, T max insulin aspart. Zambiri zinali zochepa kwa iwo omwe ali ndi vuto locheperako komanso lopweteka kwambiri.Anthu omwe ali ndi vuto la aimpso omwe amafunikira dialysis sanaphatikizidwe mu phunziroli.

Zambiri Zachitetezo Chachikulu:

Kafukufuku wammbuyo sanawonetse vuto lililonse kwa anthu, potengera kafukufuku wovomerezeka wazachipatala, kuwopsa kwa kugwiritsidwa ntchito mobwerezabwereza, genotoxicity komanso kubereka kawopsedwe.

M'mayeso a in vitro, kuphatikizapo kumangiriza ma insulin receptors ndi insulin-grow grow-1, komanso momwe zimakhudzira kukula kwa maselo, machitidwe a insulin aspart amafanana kwambiri ndi insulin yamunthu. Kafukufuku adawonetsanso kuti kudzipatula kumangiriza kwa insulin receptor ndikofanana ndi insulin yaumunthu.

Mlingo wa mankhwala a NOVORAPID Flexpen

NovoRapid Flexpen ndi machitidwe osokoneza bongo a insulin. Mlingo wa NovoRapid Flexpen umatsimikiziridwa ndi dokotala aliyense payekha malinga ndi zosowa za wodwala.

Nthawi zambiri, mankhwalawa amagwiritsidwa ntchito limodzi ndi nthawi yayitali kapena kukonzekera kwa insulini, omwe amaperekedwa pafupifupi 1 nthawi / tsiku. Kuti mukwaniritse bwino kwambiri glycemic control, tikulimbikitsidwa kuyeza kuchuluka kwa shuga m'magazi ndikusintha mlingo wa insulin. Mwachizolowezi, chinthu chofunikira tsiku lililonse cha insulin mwa akulu ndi ana kuyambira 0,5 mpaka 1 U / kg thupi. Pogwiritsa ntchito mankhwala musanadye, kufunika kwa insulin kungaperekedwe ndi mankhwala a NovoRapid Flexpen ndi 50-70%, kufunika kwa insulini kumachitika ndi insulin.

Kuchuluka kwa zochita zolimbitsa thupi kwa wodwala, kusintha kwa zakudya zomwe timakonda, kapena matenda okhudzana ndi zina zitha kuchititsa kusintha kwa mlingo.

NovoRapid Flexpen imayamba mwachangu komanso yofupika nthawi yochitirapo kanthu kuposa insulle yamunthu insulin. Chifukwa cha kuyambika mwachangu, NovoRapid Flexpen iyenera kuperekedwa, ngati lamulo, nthawi yomweyo chakudya chisanachitike, ngati kuli koyenera, chitha kuperekedweratu chakudya chisanafike.

Chifukwa chakufupika kwakanthawi poyerekeza ndi insulin yaumunthu, chiopsezo chokhala ndi nocturnal hypoglycemia mwa odwala omwe amalandila NovoRapid Flexpen ndiwotsika.

Monga kugwiritsa ntchito ma insulin ena, mwa odwala okalamba komanso odwala aimpso kapena a hepatic insuffidence, magazi a glucose ayenera kuyang'aniridwa mosamala kwambiri komanso mlingo wa aspart aspart payekha.

Ndikofunika kugwiritsa ntchito NovoRapid Flexpen m'malo mwa sungunuka wa munthu mwa ana pakakhala koyenera kuti ayambe kuchitapo kanthu, mwachitsanzo, ngati zimavuta kuti mwana asunge nthawi yoyenera pakati pakubaya ndi zakudya.

Posamutsa wodwala kuchokera ku kukonzekera kwa insulin ina ku NovoRapid Flexpen, kusintha kwa NovoRapid Flexpen ndi basal insulin kungafunike.

Njira zopewera kugwiritsa ntchito

NovoRapid Flexpen ndi singano ndizongogwiritsa ntchito nokha. Osadzazitsanso katoni katemera.

NovoRapid Flexpen silingagwiritsidwe ntchito ngati yasiya kuwonekera komanso yopanda utoto, kapena ngati yawuma. Chenjezo wodwala kutaya singano pambuyo pobayira chilichonse.

NovoRapid itha kugwiritsidwa ntchito pamapampu a insulin. Ma machubu, mkati mwake omwe amapangidwa ndi polyethylene kapena polyolefin, adayesedwa ndikupezeka kuti ndi oyenera kugwiritsidwa ntchito pamapampu. Milandu yofulumira (kuchipatala, kuvuta kwa chipangizocho popereka insulin) NovoRapid yoyendetsera wodwala imatha kuchotsedwa ku Flexpen pogwiritsa ntchito insulin syringe U100.

Muyenera kuchenjeza wodwala za momwe NovoRapid Flexpen angagwiritsidwire ntchito:

- ndi chifuwa (hypersensitivity) ku insulin aspart kapena mankhwala ena alionse

- ngati hypoglycemia iyamba,

- ngati FlexPen yagwa, kapena yawonongeka kapena yaphwanyidwa,

- ngati malo osungiramo mankhwalawo adaphwanyidwa kapena ndiuma;

- ngati insulini yasiya kukhala yowonekera komanso yopanda utoto.

Musanagwiritse ntchito NovoRapid Flexpen, wodwalayo ayenera:

- yang'aninso cholembera kuti muwonetsetse kuti mtundu woyenera wa insulin ndi wosankhidwa,

- Gwiritsani ntchito singano yatsopano jakisoni iliyonse popewa matenda.

- kumbukirani kuti NovoRapid Flexpen ndi singano zimangogwiritsidwa ntchito payekha,

- osabaya jekeseni wa insulin m'mafuta,

- Nthawi iliyonse kusintha malo a jekeseni mkati mwa anatomical, izi zithandiza kuchepetsa chiwopsezo cha zisindikizo ndi zilonda pamalo oyang'anira.

- nthawi zonse kuyeza kuchuluka kwa shuga m'magazi.

Malangizo a kayendetsedwe ka mankhwala

NovoRapid Flexpen ndi jekeseni sc m'dera la anterior m'mimba khoma, ntchafu, phewa, deltoid kapena gluteal dera. Mawebusayiti omwe ali mkati mwa thupi limodzi amayenera kusinthidwa pafupipafupi kuti muchepetse vuto la lipodystrophy. Monga kukonzekera konse kwa insulin, kuyika kwina kwa khoma lakunja kwam'mimba kumayamwa mwachangu poyerekeza ndi kayendetsedwe ka malo ena. Kutalika kwa zochita zimatengera mlingo, malo oyendetsera, kutsika kwa magazi, kutentha ndi kuchuluka kwa zochitika zolimbitsa thupi. Komabe, kuyambitsa mwachangu poyerekeza ndi insulin ya anthu sungunuka mosasamala malo omwe jakisoniyo anali.

NovoRapid itha kugwiritsidwa ntchito popitilira s / c insulin infusions (PPII) m'mapampu a insulin omwe amapangidwira insulin infusions. FDI iyenera kupangidwa khoma lakunja kwam'mimba. Malo olowetsedwa amayenera kusinthidwa nthawi ndi nthawi. Mukamagwiritsa ntchito pampu ya insulini kulowetsedwa, NovoRapid sayenera kusakanikirana ndi mitundu ina ya insulin.

Odwala omwe akugwiritsa ntchito FDI ayenera kuphunzitsidwa bwino kugwiritsa ntchito pampu, chosungira choyenera, ndi dongosolo la ma pump pump. The kulowetsedwa set (chubu ndi catheter) ziyenera m'malo mwa wogwiritsa buku malangizo ophatikizidwa ndi kulowetsedwa. Odwala omwe amalandila NovoRapid ndi FDI ayenera kukhala ndi insulini yowonjezera kuti ikwaniritse kulowetsedwa.

Ngati ndi kotheka, NovoRapid imatha kuyikamo /, koma okhawo odziwa ntchito zachipatala oyenerera. Pa kulowetsedwa kwa mtsempha, makina a kulowetsedwa ndi NovoRapid 100 U / ml okhala ndi 0.05 U / ml mpaka 1 U / ml insulin aspart mu 0.9% sodium chloride solution, 5% dextrose solution kapena 10% dextrose solution yokhala ndi 40 mmol / ntchito l potaziyamu kolorayidi pogwiritsa ntchito polypropylene kulowetsedwa muli. Njira zoterezi ndizokhazikika pofunda kwa maola 24. Ngakhale kukhazikika kwakanthawi, chiwopsezo china cha insulin choyambirira chimatengedwa ndi zinthu zam'kati mwa kulowetsedwa. Pa insulin infusions, ndikofunikira kuyang'anira kuchuluka kwa shuga m'magazi.

NovoRapid Flexpen ndi cholembera cha insulin ndi cholembera ndi cholembera. Mlingo wa insulin womwe umayendetsedwa, kuyambira 1 mpaka 60 mayunitsi, umatha kusiyanasiyana mu 1 unit. NovoRapid Flexpen idapangidwa kuti igwiritsidwe ntchito ndi singano za NovoFayn ndi NovoTvist mpaka 8 mm. Monga kusamala, nthawi zonse muziyenera kukhala ndi pulogalamu yopuma kuti mupereke insulin ngati itayika kapena kuwonongeka kwa NovoRapid Flexpen.

Musanagwiritse ntchito cholembera

1. Chongani cholembera kuti mutsimikizire kuti NovoRapid Flexpen ali ndi mtundu woyenera wa insulin.

2. Chotsani kapu mu cholembera.

3. Chotsani chimata chomuteteza ku singano yotaya. Yanikani singano mokoma komanso mwamphamvu pa NovoRapid Flexpen. Chotsani kapu yakunja kuchokera singano, koma osataya. Chotsani ndikutaya kapu yamkati ya singano.

Gwiritsani ntchito singano yatsopano jekeseni aliyense kupewa matenda.Osapinda kapena kuwononga singano musanagwiritse ntchito. Popewa kubayidwa mwangozi, musabwezeretse cholowera chamkati pa singano.

Chingwe cha Insulin

Ngakhale mutagwiritsidwa ntchito moyenera ndi cholembera, mpweya wochepa umatha kudziunjikira mu cartridge musanadye jekeseni iliyonse. Poletsa kulowa kwa kuwira kwa mpweya ndikuwonetsetsa kuti mankhwala ayambitsidwa molondola:

1. Imbani 2 magawo a mankhwala ndikusintha chosankha.

2. Mukangogwirizira NovoRapid Flexpen ndi singano mmwamba, dinani pang'ono kangapo pa cartridge ndi chala chanu kuti thovu lakuthwa lisunthire pamwamba pa cartridge.

3. Mukugwira NovoRapid Flexpen ndi singano mmwamba, kanikizani batani loyambira njira yonse. Osankha Mlingo abwerera ku "0".

Dontho la insulin liyenera kuonekera kumapeto kwa singano. Ngati izi sizingachitike, sinthani singano ndikubwereza njirayi, koma osapitirira 6. Ngati insulini siyikuchokera singano, izi zikuwonetsa kuti cholembera sichili chosalongosoka ndipo sayenera kugwiritsanso ntchito.

Wosankha mlingo uyenera kukhala "0".

Sungani ziwerengero zomwe zimafunikira jakisoni. Mlingo umatha kusinthidwa ndikusinthanitsa ndi mtundu wosankhidwa mwanjira iliyonse mpaka mlingo woyenera wakhazikitsidwa kutsogolo kwa chizindikiro. Mukazungulira chosankha cha mankhwala, samalani kuti musakanize mwangozi batani loyambira kuti muchepetse kutulutsa kwa insulin. Sizotheka kukhazikitsa mlingo woposa kuchuluka kwa zigawo zomwe zatsalira mu cartridge.

Osagwiritsa ntchito mulingo wotsalira kuti mupeze Mlingo wa insulin.

1. Ikani singano sc. Wodwala ayenera kugwiritsa ntchito jakisoni wovomerezeka ndi dokotala. Kuti mupeze jakisoni, dinani batani loyambira mpaka "0" akuwonekera kutsogolo kwa chizindikiro. Mukapereka mankhwala, batani loyambira lokha lomwe liyenera kukanikizidwa. Mlingo wosankha ngati utasinthidwa, makonzedwe a mlingo sangachitike.

2. Mukachotsa singano pansi pa khungu, gwiritsani batani loyambira ndikukhumudwa kwathunthu. Pambuyo pa jekeseni, siyani singano pansi pa khungu kwa masekondi 6 osachepera. Izi zikuthandizira kukhazikitsidwa kwa insulin yonse.

3. Yambitsirani singano mumkono wakunja wa singano osakhudza cap. Pamene singano ilowa, valani chipewa ndikuvula singano. Taya singano, samalira chitetezo, ndikutseka cholembera ndi chophimba.

Singano imayenera kuchotsedwa pambuyo pobayidwa aliyense ndipo osasunga NovoRapid Flexpen ndi singano yomata. Kupanda kutero, madzi amatha kutuluka kuchokera ku NovoRapid Flexpen, komwe kungayambitse mlingo woyenera.

Osamalira amayenera kusamala pochotsa ndi kutaya singano kuti apewe ngozi yotenga singano mwangozi.

Tayani ntchito NovoRapid Flexpen ndi singano yolumikizidwa.

NovoRapid Flexpen adapangidwa kuti azigwiritsa ntchito payekha.

Kusunga ndi chisamaliro

NovoRapid Flexpen idapangidwa kuti izigwiritsidwa ntchito moyenera komanso mosatetezeka ndipo imafunikira kuisamalira mosamala. Pakakhala dontho kapena kupanikizika kwamakina mwamphamvu, cholembera cha syringe chimatha kuwonongeka ndipo insulin ikhoza kutayikira. Pamwamba pa NovoRapid Flexpen akhoza kutsukidwa ndi thonje swab choviikidwa mu mowa. Osamiza chindapusa mu mowa, osasamba kapena mafuta izi zitha kuwononga makina. Kudzazidwanso kwa NovoRapid Flexpen sikuloledwa.

Kuyanjana kwa mankhwala osokoneza bongo

Hypoglycemic zotsatira za insulin patsogolo mankhwala m'kamwa hypoglycemic, Mao zoletsa, zoletsa Ace, carbonic zoletsa anhydrase, kusankha beta-blockers, bromocriptine, sulfonamides, anabolic mankhwala, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, mankhwala lifiyamu salicylates.

Njira zakulera za pakamwa, GCS, mahomoni a chithokomiro, thiazide diuretics, heparin, tridclic antidepressants, sympathomimetics, somatropin, danazole, clonidine, calcium njira blockers, diazoxide, morphine, phenytoin, kufooketsa hypoglycemic zotsatira za insulin.

Beta-blockers amatha kufinya zizindikiro za hypoglycemia.

Octreotide / lanreotide imatha kuwonjezeka ndikuchepetsa kufunika kwa insulin. Mowa ungapangitse komanso kuchepetsa mphamvu ya insulin.

Mankhwala okhala ndi magulu a thiol kapena sulfite, akaphatikizidwa ku mankhwala a NovoRapid Flexpen, angayambitse kuwonongeka kwa insulin. NovoRapid Flexpen sayenera kusakanikirana ndi mankhwala ena. Zosiyanazo ndi insulin-isophan ndi mayankho a kulowetsedwa omwe alembedwa pamwambapa.

Kugwiritsa ntchito kwa NOVORAPID Flexpen panthawi yapakati

NovoRapid Flexpen imatha kutchulidwa panthawi yapakati. Mayeso awiri azachipatala omwe adayang'aniridwa mosasamala (157 + 14 amayi oyembekezera omwe adawunikidwa) sanawonetse zovuta zilizonse za insulin aspart pa mimba kapena thanzi la mwana wosabadwayo / wakhanda poyerekeza ndi insulin yaumunthu.

Kuwunikira mosamala kuchuluka kwa shuga m'magazi ndikuwunika azimayi oyembekezera omwe ali ndi matenda osokoneza bongo (mtundu 1, mtundu wachiwiri kapena matenda ashuga) pakubala konse, komanso panthawi yomwe ali ndi pakati, amalimbikitsidwa. Kufunika kwa insulini, monga lamulo, kumachepa mu trimester yoyamba ndipo pang'onopang'ono kumawonjezeka muyezo wachiwiri komanso wachitatu wamapazi oyembekezera. Pambuyo pobadwa, kufunikira kwa insulin kumabwereranso msanga momwe kunaliri asanakhale ndi pakati.

Pa yoyamwitsa, NovoRapid Flexpen angagwiritsidwe ntchito popanda zoletsa, chifukwa kuperekera insulin kwa mayi woyamwitsa sikuopseza mwana. Komabe, zingakhale zofunikira kusintha mlingo wa mankhwalawo.

NOVORAPID Thawitsani - mavuto

Zotsatira zoyipa zomwe zimachitika mwa odwala omwe amalandila NovoRapid Flexpen amadalira kwambiri mlingo wa mankhwalawa ndipo chifukwa cha mankhwala a insulin. Chochitika chovuta kwambiri chambiri ndi insulin ndi hypoglycemia.

Pa gawo loyambirira la insulin, zolakwika zotupa, edema ndi zochita zake zimatha kupezeka pamalo a jakisoni (kupweteka, kufiyira, ming'oma, kutupa, hematoma, kutupa ndi kuyabwa pamalowo jakisoni. Zizindikirozi nthawi zambiri zimakhala zachilengedwe. Kusintha kwapang'onopang'ono pakuwongolera glycemic kumatha kubweretsa mkhalidwe wa ululu wammbuyo wammbuyo, womwe nthawi zambiri umatha kusintha. Kulimbitsa insulin mankhwala ndikusintha kolimba kwa mphamvu ya kagayidwe kazakudya kungayambitse kuwonongeka kwakanthawi pamikhalidwe ya matenda ashuga, pamene kusintha kwakanthawi kwakanthawi ka glycemic kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy.

Zoyipa zonse zomwe zimaperekedwa pagome, kutengera deta yomwe idapezedwa pakayesedwe kachipatala, zimagawika m'magulu molingana ndi kukula kwa chitukuko motsatira ndondomeko ya MedDRA ndi ziwalo. Kutsimikiza kwamafotokozedwe azovuta: nthawi zambiri (≥1 / 10), nthawi zambiri (≥1 / 100 kuti

Zochitika kawirikawiri kwambiri zamagulu a hypersensitivity (kuphatikizapo kuphathamira pakhungu, kuyabwa, kuchuluka kwa thukuta, kusokonezeka kwa m'mimba, angioedema, kupuma movutikira, kuthamanga kwa mtima, kuchepa kwa magazi), zomwe zingakhale zowopsa m'moyo, zimadziwika.

Hypoglycemia ndi njira yodziwika kwambiri yotsatirira. Zimatha kukhala ngati mlingo wa insulini ndiwokwera kwambiri poyerekeza ndi kufunika kwa insulin. Hypoglycemia yambiri imatha kuyambitsa chikumbumtima ndi / kapena kukhumudwa, kusokonezeka kwakanthawi kapena kosasintha kwa ntchito yaubongo, ngakhale imfa. Zizindikiro za hypoglycemia, monga lamulo, zimayamba mwadzidzidzi. Izi zitha kuphatikizira "thukuta lozizira," kukhuthala kwa khungu, kutopa kwambiri, mantha kapena kunjenjemera, nkhawa, kutopa kapena zachilendo, kufooka, kuchepa kwa chidwi, kugona, kugona tulo, kugona tulo, mutu, nseru, komanso kupweteka mtima. . Kafukufuku wachipatala adawonetsa kuti kuchuluka kwa hypoglycemia kumasiyana malinga ndi kuchuluka kwa odwala, dosing regimen, ndi glycemic control. M'mayesero azachipatala, panalibe kusiyana kulikonse pazochitika za hypoglycemia pakati pa odwala omwe amalandila chithandizo cha inshuwaransi ndi odwala omwe amalandila kukonzekera kwa insulin.

Nthawi zambiri za lipodystrophy zalembedwa. Lipodystrophy imatha kupezeka pamalo a jakisoni.

Migwirizano ndi machitidwe akusungidwa kwa mankhwala NOVORAPID Flexpen

Mankhwalawa amayenera kusungidwa pa kutentha kwa 2 ° mpaka 8 ° C (mufiriji), koma osati pafupi ndi mufiriji, osazizira. Kuti muteteze kuchokera ku kuwala, sungani NovoRapid ® FlexPen ® yokhala ndi kapu yodzitchinjiriza. Moyo wa alumali - miyezi 30.

NovoRapid ® FlexPen ® iyenera kutetezedwa ku kutentha kwakukulu ndi kuwala.

Musasungire kapena kugwiritsa ntchito cholembera ndi syringe ndi njira yomwe mwagwirira ntchito kapena kuisungitsa ngati syringe yosalala mufiriji. Sungani ku kutentha kosaposa 30 ° C. Gwiritsani ntchito pakatha milungu 4.

Mankhwala ayenera kusungidwa kuti ana asawafikire.

Mapangidwe a odwala matenda ashuga

Mankhwala a NovoRapid diabetesic (insulin) amapangidwa m'njira ziwiri - awa ndi ma cartridge a Penfill osinthika ndi zolembera zopangidwa ndi FlexPen.

Kapangidwe ka cartridge ndi cholembera ndi chimodzimodzi - ndi madzi omveka bwino a jekeseni, pomwe 1 ml ili ndi gawo la insulin aspart mu 100 PISCES. Makatoni amodzi osinthika, ngati cholembera chimodzi, ali ndi pafupifupi 3 ml yankho, ndilo magawo 300.

Makatoni amapangidwa ndi galasi la hydrolytic la gulu la I. Wotsekedwa mbali imodzi ndi ma disisi a polyisoprene ndi ma brongosutyl, mbali inayo ndi pistoni zapadera za rabara. Pali makatoni asanu ogwiritsidwanso ntchito pachimake cha aluminiyamu, ndipo chithuza chimodzi chimangiriridwa m'bokosi lamatoni. Momwemonso zolembera za syringe ya FlexPen zimapangidwa. Ndizotayidwa ndipo ndizopangidwira mitundu ingapo. Pali asanu m'khadibhodi.

Mankhwalawa amasungidwa m'malo ozizira kutentha kwa 2-8 ° C. Sichiyenera kuyikidwa pafupi ndi mufiriji, komanso siyenera kuzizira. Komanso makatoni omwe amatha kusintha ndi ma syringe ayenera kutetezedwa ndi dzuwa. Ngati NovoRapid insulin (cartridge) itatsegulidwa, sangathe kusungidwa mufiriji, koma iyenera kugwiritsidwa ntchito kwa milungu inayi. Kutentha kosungira sikuyenera kupitirira 30 ° C. Moyo wa alumali wa insulin wosatsimikizika ndi miyezi 30.

Kufotokozera kwa mahomoni

NovoRapid ndi analogue yaifupi ya insulin ya anthu. Chosakaniza chophatikizacho ndi insulin Aspart. Mankhwalawa amapangidwa ndi kupanga ma genetic, m'malo mwa proline ndi aspartic amino acid. Izi sizimalola mapangidwe a hexamers, timadzi timadzi timadzi timitengo iti tomwe timatulutsa mafuta ambiri. Ikuwonetsa momwe zimakhalira pakadutsa mphindi 10 mpaka 20, zotsatira zake sizikhala motalikirapo ndi insulin wamba, maola 4 okha.

Zotsatira za pharmacological

NovoRapid imawoneka ngati yankho lopanda mtundu. 1 ml ili ndi mayunitsi 100 (3.5 mg) a insulin Aspart. Zotsatira zake kwachilengedwe zimakhazikitsidwa chifukwa cha mgwirizano wa mahomoni ndi ma membrane a cell membrane. Izi zimapangitsa kuti pakhale michere yayikulu:

• Hexokinase.
• Pyruvate kinase.
• Glycogen synthases.

Amagwira nawo kagayidwe ka glucose, amathandizira kuthamanga kwa magwiritsidwe ake ndikuchepetsa kuchuluka kwa magazi m'magazi. Imaperekedwanso ndi njira zotsatirazi:

• Anawonjezera lipogenesis.
• Kukondoweza kwa glycogenogeneis.
• Kuthamanga kugwiritsa ntchito minofu.
• Kuletsa kwa kaphatikizidwe ka shuga m'magazi.

Kugwiritsa ntchito NovoRapid kokha sikutheka, imayendetsedwa ku Levemir, yomwe imawonetsetsa kuti insulin ikukhazikika pakati pa chakudya.

Kafukufuku wokhudzana ndi zamankhwala a flekspennogo mankhwala adawonetsa kuti akuluakulu, mwayi wa hypoglycemia usiku umachepetsedwa poyerekeza ndi insulin yachikhalidwe. Mankhwalawa adakwaniritsidwa pokhalabe ndi matenda a typoglycemia mwa okalamba omwe ali ndi matenda a shuga a 2 komanso akapatsidwa ana.

Mwa azimayi omwe ali ndi matenda amtundu wa 1 omwe adapezeka kuti ali ndi pakati, sizikhudza mwana wosabadwa kapena mayeso. Kugwiritsidwa ntchito kwa NovoRapid Flekspen insulin pochiza matenda ashuga (omwe adapezeka koyamba panthawi yomwe ali ndi pakati) akhoza kupititsa patsogolo kuwongolera msana wa glycemia mukatha kudya.

Tiyenera kukumbukira kuti zochita za insulort insulin ndizamphamvu kwambiri kuposa zamasiku onse. Mwachitsanzo, 1 Unit NovoRapida imakhala yolimba nthawi 1.5 kuposa insulin. Chifukwa chake, mlingo uyenera kuchepetsedwa pakayendetsedwe kamodzi.

Novorapid amayamba kuchita pakadutsa mphindi 10-20, zotsatira zake zimatha maola 4

Ndani amasankhidwa mahomoni, ndipo ndani amatsutsana?

Kuti mupeze NovoRapid, wodwala ayenera kupezeka:

• Mtundu woyamba wa shuga.
• Type 2 shuga mellitus ofuna kuphatikiza insulin ndi mapiritsi.
• Matenda a shuga.

Mankhwalawa amachepetsa mosavuta shuga amayi oyembekezera, monga momwe zimatsimikizidwira ndi mayesero azachipatala.

Chithandizo chimaphatikizidwa ngati munthu ali ndi vuto la mankhwala, komanso ana osakwana zaka 2: Zoyeserera zamankhwala kwa ana aang'ono sizinachitike. Panthawi yoyamwitsa, iye samakhala ndi vuto kwa mwana, koma kuchuluka kwa mayunitsi kuyenera kusintha.

Zotsatira zoyipa

Zotsatira zosasangalatsa za kukonzekera kwa inshuwaransi ya NovoRapid mu mawonekedwe a cartks ya Flekspen ndi chifukwa cha insulin yomwe. Imatha kutsitsa glucose kukhala mkhalidwe wa hypoglycemia.

Mankhwala akayamba, zotsatira zoyipa zimatha kuoneka, zomwe zimatha:

• Zododometsa.
• Ululu, hyperemia ndi kutupa m'malo a jakisoni.
• Hematomas pamalo opangira jekeseni.
• Pachimake ululu neuropathy.

Pang'onopang'ono, mawonekedwe awa amawonekera. Zotsatira zina zimayamba kuperewera:

1. Pa mbali ya chitetezo chathupi - urticaria, zotupa pakhungu, anaphylactic zimachitika.
2. Kuchokera pamawonedwe - retinopathy, zolakwitsa zina.
3. Kusowa pang'ono kapena kwathunthu kwa zotumphukira za adipose pamalo opangira jakisoni.

Kusankha kolakwika ndi kumwa mopitirira muyeso kumabweretsa kukula kwa vuto - hypoglycemia. Zizindikiro zake zimawonekera mwadzidzidzi. Kuda nkhawa ndi kufooka, chizungulire, pallor, nseru, kugona. Wodwalayo amaponyedwa thukuta, chidwi ndi masomphenya amasokonekera. Muzochitika zazikulu, kusiya kukumbukira kumachitika, kusintha kosasintha mu ubongo ndi kufa. Chifukwa chake, ndikofunikira kusankha mlingo woyenera, woperekera mankhwalawa panthawi.

Mlingo ndi makonzedwe

Angati magawo a hormone ya fleksponny ndiyofunikira, adokotala amasankha payekhapayekha. Kuchuluka kwa insulini kotani kumawerengeredwa potengera kuti munthu amafunikira theka kapena gawo limodzi pa kilogalamu ya kulemera patsiku. Chithandizo chimagwirizana ndi zakudya. Nthawi yomweyo, mahashoni a ultrashort amaphimba mpaka 70% ya zofunikira za mahomoni, 30% yotsalayo imakutidwa ndi insulin yayitali.

Penfill insulin NovoRapid iyenera kugwiritsidwa ntchito kwa mphindi 10-15 musanadye

Penofill insulin NovoRapid imayendetsedwa kwa mphindi 10-15 musanadye. Ngati jakisoni adaphonya, ndiye kuti akhoza kulowetsedwa osachedwa mukatha kudya.Kuchuluka kwazinthu zambiri kumadalira malo a jakisoni, kuchuluka kwa magawo a mahomoni m'thupi, zochita zolimbitsa thupi ndi mafuta omwe amatengedwa.

Malinga ndi zomwe zikuwonetsa, mankhwalawa amatha kugwiritsidwa ntchito mobala. Pampu ya insulin (pampu) imagwiritsidwanso ntchito pakukhazikitsa. Ndi chithandizo chake, timadzi timene timayendetsedwa kwa nthawi yayitali pansi pa khungu la khoma lamkati lakumbuyo, nthawi ndi nthawi kusintha magawo a jekeseni. Ndikosatheka kusungunuka mukukonzekera kwina kwa mahomoni a kapamba.

Kuti mugwiritse ntchito intravenous, yankho limatengedwa lomwe limakhala ndi insulini mpaka 100 U / ml, kuchepetsedwa mu 0,9% sodium chloride, 5% kapena 10% dextrose. Panthawi ya kulowetsedwa, amawongolera shuga.

NovoRapid imapezeka mu cholembera cha Flekspen syringe ndi ma cartridge a Penfill m'malo mwake. Cholembera chimodzi chimakhala ndi mayunitsi 300 am'madzi mu 3 ml. Syringe imagwiritsidwa ntchito payekha.

Phukusi losatsegulidwa limasungidwa mufiriji pa madigiri 2-8, koma mulimonsemo sauma. Pambuyo kutsegulira imasungidwa kutentha, kuteteza ku dzuwa ndi kutentha kwambiri madigiri 30.

Chogwirira chimagwiritsidwa ntchito ndi singano zotayidwa ndipo chimakhala ndi chopereka. Kuti mupeze jakisoni, muyenera kuchotsa kapu, chomata pachingano ndikuyiphatikiza ndi syringe. Jekeseni aliyense amafunika kusintha kwa singano. Kuti mumasule ma Bubulo am'mlengalenga, kugwiritsa ntchito mitundu iwiri ya mahomoni. Chingwecho chimayikidwa pansi ndi singano, ndikutchingira pang'ono. Ma Bubulo akasunthira mmwamba, dinani batani loyambira. Dontho la yankho liyenera kuwonekera pakudula kwa singano. Ngati izi sizingachitike, njirayi imabwerezedwa mpaka 6. Kuperewera kwa zotsatira kumawonetsa kuti siligwira bwino ntchito ya syringe.

Pambuyo pake, mlingo womwe adayikidwa ndi adokotala wakhazikitsidwa. Kuti muwongolere mankhwalawa, kanikizani batani loyambira ndikugwiritsitsa mpaka wosankhayo ali mu zero. Pambuyo pa jekeseni, kapu imayikidwa mu singano ndikuitaya.

Ultrashort insulin analogi ndi mtengo

NovoRapid ali ndi mawonekedwe amakono omwe ali ofanana ndi iwo mu kuchitapo ndi chitukuko cha zotsatira zake. Awa ndi mankhwala a Apidra ndi Humalog. Humalog imathamanga: 1 unit imagwira ntchito nthawi 2.5 mochulukirapo kuposa kuchuluka komweko kwa mahomoni ofupikirako. Mphamvu ya Apidra imayamba pa liwiro limodzimodzi ndi NovoRapida.

Mtengo wa zolembera za 5 Flexpen syringe ndi pafupi ma ruble 1930. Katoni yonyongedwa ya Penfill imakhala ndi ma ruble 1800. Mtengo wa analogues, womwe umapezekanso m'mapensulo a syringe, umakhala wofanana ndipo umachokera ku 1700 mpaka 1900 rubles muma pharmacies osiyanasiyana.

Pomaliza

Chithandizo cha matenda ashuga chimapangidwa kuti azisamalira Normoglycemia. Kuti akwaniritse zofunika za shuga, wodwala amamuika mankhwala oyambira. Dokotala amapanga kusankha kwa mankhwala enaake potsatira kuwunika kwa glucose panthawi zosiyanasiyana za tsiku. Chifukwa chakuchita kwakanthawi kochepa, ma insulin amafupikitsa omwe amaperekedwa kwa odwala omwe sakudziwa nthawi yomwe adzadye. Kwa ambiri, ma insulin amafupikitsa okha.

Pofuna kuchiza matenda a shuga, akatswiri a zamankhwala apanga mitundu ingapo ya mankhwala osiyanasiyana. Insulin ndiye mankhwala othandiza kwambiri pochiza matenda. Monga mankhwala ambiri, amagawika m'magulu angapo a mankhwala. Yothandiza kwambiri ndi insulin Novorapid. Pali mitundu yosiyanasiyana ya Novorapid insulin: Flekspen, Aspart.

Zomwe madotolo amati pa matenda ashuga

Doctor of Medical Science, Pulofesa Aronova S. M.

Kwa zaka zambiri ndakhala ndikuphunzira za zovuta za DIABETES. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinology Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 100%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipilira mtengo wonse wa mankhwalawo.Ku Russia ndi mayiko a CIS odwala matenda ashuga kale atha kupeza mankhwala ZAULERE .

Kupanga ndi mawonekedwe a kumasulidwa

Mankhwala amtunduwu ndi ofanana ndi mtundu wa insulin. Ndi chifukwa cha izi kuti mankhwalawa amadziwika ndi mtundu wawo wapamwamba kwambiri. Maziko a mankhwalawa ndi mankhwala a Aspart. Mankhwalawa ali ndi njira ziwiri zogwiritsira ntchito: mwa jekeseni wamkati,

Novorapid ilibe mtundu, ndimadzimadzi owoneka popanda zosayera. Mankhwalawa amapangidwa mwanjira yama cartridges opangidwa ndi galasi lopanda utoto.

Samalani

Malinga ndi WHO, chaka chilichonse padziko lapansi anthu 2 miliyoni amafa chifukwa cha matenda ashuga komanso zovuta zake. Pokhapokha pakhale thandizo loyenerera la thupi, matenda ashuga amabweretsa mavuto osiyanasiyana, pang'onopang'ono kuwononga thupi la munthu.

Mavuto omwe amakonda kwambiri ndi awa: matenda a shuga a shuga, nephropathy, retinopathy, trophic zilonda zam'mimba, hypoglycemia, ketoacidosis. Matenda a shuga amathanso kuyambitsa kukula kwa zotupa za khansa. Pafupifupi nthawi zonse, wodwala matenda ashuga amwalira, akulimbana ndi matenda opweteka, kapena amasintha kukhala munthu weniweni wolumala.

Kodi anthu odwala matenda ashuga amatani? Endocrinological Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga chida chomwe chimachiritsa kwathunthu matenda a shuga.

Pulogalamu ya Federal "Health Health Nation" ikuchitika, mkati mwa momwe mankhwalawa amaperekedwa kwa aliyense wokhala ku Russian Federation ndi CIS ZAULERE . Kuti mumve zambiri, onani tsamba lovomerezeka la MINZDRAVA.

Pazifukwa zina, dokotala angasinthe mlingo:

• zochita zolimbitsa thupi,
• Matenda ena opweteka omwe amachulukitsa Zizindikiro za matenda ashuga,
• kukulira vuto la wodwala,
• kumwa mankhwala, gulu lina la mankhwala.

Mankhwalawa amaperekedwa pansi pakhungu pogwiritsa ntchito syringe yapadera. Ogwira ntchito zachipatala amatha kupereka insulin kudzera m'mitsempha.

Gwiritsani ntchito mosamala

Mankhwala aliwonse amawonetsa, omwe ayenera kugwiritsidwa ntchito mosamala, kapena kuchotsera kwathunthu:

• katoni iliyonse imagwiritsidwa ntchito kamodzi. Sizoletsedwa kugwiritsa ntchito mankhwala omwe ali kale kale. Ndi jakisoni watsopano, gwiritsani ntchito syringe yonyansa,
• osagwiritsa ntchito mankhwalawa ngati yankho lake ndi mitambo kapena lili ndi mthunzi,
• kugwiritsa ntchito insulin mwachangu, gwiritsani ntchito syringe U100.

Owerenga athu amalemba

Mutu: Matenda a shuga apambana

Ku: my-diabet.ru Administration

Ndili ndi zaka 47, ndinapezeka kuti ndili ndi matenda ashuga a 2. M'masabata angapo ndinapeza pafupifupi 15 kg. Kutopa nthawi zonse, kugona, kumva kufooka, kuwona kunayamba kukhala pansi. Nditakwanitsa zaka 66, ndinali ndikumenya insulin yanga, zonse zinali zoipa kwambiri.

Nayi nkhani yanga

Matendawa adapitilirabe, kukomoka kwakanthawi kunayamba, ambulansi imandibwezera kuchokera kudziko lina. Nthawi zonse ndimaganiza kuti nthawi ino ikhala yomaliza.

Chilichonse chinasintha mwana wanga wamkazi atandilola kuti ndiwerenge nkhani imodzi pa intaneti. Simungayerekeze m'mene ndimamuyamikirira. Nkhaniyi inandithandiza kuthana ndi matenda ashuga, omwe amati ndi osachiritsika. Zaka 2 zapitazi ndidayamba kusuntha kwambiri, nthawi yamasika ndi chilimwe ndimapita kumayiko tsiku lililonse, timakhala ndi moyo wachangu ndi amuna anga, timayenda maulendo ataliatali. Aliyense amadabwitsidwa ndimomwe ndimakwanitsira chilichonse, komwe ndimatha mphamvu zambiri, sakhulupirira kuti ndili ndi zaka 66 zakubadwa.

Ndani akufuna kukhala ndi moyo wautali, wamphamvu komanso kuiwalako za matenda oyipawa kwamuyaya, tengani mphindi 5 ndikuwerenga nkhaniyi.

Pitani pa nkhaniyi >>>

Novorapid imasungidwa pa kutentha kwa madigiri 2-8. Ndikofunika kuyika mankhwalawo mufiriji, koma pewani kuzizira. Chotsani chiwonetsero cha dzuwa mwachindunji ndikuyang'anira tsiku lomwe lisungidwe.

Insulin

Kwa inshuwaransi ya Aspart, malangizo amomwe mungagwiritsire ntchito. Kuchiwona, mudzapewa mavuto ambiri okhudzana ndi kutenga "Astarta".

Mtundu wa insulin ndi madzimadzi a magawo awiri okhala ndi insulin yotulutsa dzuwa ndi 30% ndi galasi la crystalline ndi 70%. Aspart ndi yofanana ndi insulin yaumunthu, koma imakhala yochepa. Ili ndi adsorption yayikulu, yomwe imakupatsani mwayi kusintha mwachangu, ngakhale mawonekedwe ovuta.

Pharmacology

Mankhwala a NovoRapid (insulin) amakhala ndi vuto la hypoglycemic, ndipo gawo lomwe limagwira, insulini aspart, ndi chida chofanizira cha timadzi tambiri tomwe timapanga. Katunduyu amapezeka pogwiritsa ntchito mitundu yapadera ya DNA. Vuto la Saccharomyces cerevisiae limawonjezeredwa pano, ndipo amino acid yotchedwa "proline" imasinthidwa kwakanthawi ndi wina wokhala ndi chidwi.

Mankhwalawa amakumana ndi zolandilira zam'mimba za cytoplasmic yama cell, pomwe amapanga zovuta zonse za insulin, amapangitsa njira zonse zomwe zimachitika mkati mwa maselo. Pambuyo pakuchepa kwa kuchuluka kwa shuga mu plasma, kuchuluka kwa zoyendera zamkati, kuwonjezeka kwa zotengera zosiyanasiyana, kuwonjezeka kwa glycogenogeneis ndi lipogenesis. Kuchuluka kwa shuga komwe kumachitika m'chiwindi kumachepa.

Kusintha amino acid proline ndi Aspartic acid mukakumana ndi insulin aspart kumachepetsa kuthekera kwa mamolekyulu kupanga hexamers. Homoni yamtunduwu imamwedwa bwino ndi mafuta a subcutaneous, amakhudza thupi mofulumira kuposa kutengera kwa insulin yaumunthu.

M'mahola anayi atatha kudya, insulin amachepetsa msempha wa plasma mwachangu kuposa mahomoni amtundu wa munthu. Koma zotsatira za NovoRapida ndi subcutaneous management ndizofupikirapo kuposa zomwe zimasungunuka ndi anthu.

Kodi NovoRapid amagwira ntchito nthawi yayitali bwanji? Funsoli limadetsa nkhawa anthu ambiri omwe ali ndi matenda ashuga. Chifukwa chake, mphamvu ya mankhwalawa imachitika pambuyo pa mphindi 10-20 pambuyo pa jekeseni. Kuphatikiza kwakukulu kwa mahomoni m'mwazi kumawonedwa patatha maola 1-3 mutatha kugwiritsa ntchito mankhwalawa. Chidacho chimakhudza thupi kwa maola 3-5.

Kafukufuku wa anthu omwe ali ndi matenda a shuga a I adawonetsa kuchepa kwakawiri pachiwopsezo cha nocturnal hypoglycemia ndi NovoRapid, makamaka poyerekeza ndi kuyamwa kwa insulin yamunthu. Kuphatikiza apo, panali kuchepa kwakukulu kwa gluprose wa postprandial mu plasma pamene adabayidwa ndi insulin aspart.

Zizindikiro ndi contraindication

Mankhwala NovoRapid (insulin) amapangidwira anthu omwe ali ndi matenda a shuga 1, omwe amadalira insulin, komanso odwala omwe ali ndi matenda a shuga 2 - osagwirizana ndi insulin omwe amadalira pakamwa motsutsana ndi hypoglycemic mankhwala omwe amatengedwa pakamwa, komanso matendawa. .

Contraindication kugwiritsa ntchito mankhwalawa ndi hypoglycemia ndi chidwi chokhudza thupi insulin aspart, okonda mankhwala.

Osagwiritsa ntchito NovoRapid wa ana ochepera zaka zisanu ndi chimodzi chifukwa chakusowa kwa maphunziro azachipatala.

Mankhwala "NovoRapid": malangizo ogwiritsira ntchito

Mankhwala NovoRapid ndi analogue a insulin. Imayamba kuchita nthawi yomweyo jekeseni. Mlingo wa wodwala aliyense ndiwawokha ndipo amasankhidwa ndi adokotala. Kuti mukwaniritse bwino, timadzi timeneti timaphatikizidwa ndi insulin ya nthawi yayitali kapena yapakati.

Pofuna kuthana ndi glycemia, kuchuluka kwa shuga m'magazi kumayeza nthawi zonse ndipo mlingo wa insulin umasankhidwa mosamala. Monga lamulo, mlingo wa tsiku ndi tsiku wa akulu ndi ana umachokera ku 0.5-1 U / kg.

Mukalandira jekeseni wa mankhwala a NovoRapid (malangizo omwe angagwiritsidwe ntchito amafotokozera mwatsatanetsatane dongosolo la mankhwalawa), kufunikira kwa insulin kumaperekedwa ndi 50-70%. Ena onse amakhutitsidwa ndi kuyendetsedwa kwa insulin yayitali (ya nthawi yayitali).Kuwonjezeka kwa zochita zolimbitsa thupi kwa wodwala komanso kusintha kwa zakudya, komanso zomwe zikuchitika kale, zimapangitsa kusintha kwa mlingo womwe waperekedwa.

Hormons NovoRapid, mosiyana ndi munthu wosungunuka, amayamba kuchita zinthu mwachangu, koma osapitirira. Pang'onopang'ono makonzedwe a insulini akusonyezedwa. Algorithm ya jakisoni imaphatikizapo kugwiritsa ntchito mankhwala musanadye chakudya, ndipo ngati pakufunika thandizo, mankhwalawo amagwiritsidwa ntchito mukangodya.

Chifukwa chakuti NovoRapid amachita thupi kwakanthawi kochepa, chiopsezo cha hypoglycemia usiku mwa odwala matenda a shuga amachepetsa kwambiri.

Odwala okalamba, komanso kwa anthu omwe ali ndi vuto laimpso kapena kwa chiwindi, kuwongolera kwa glucose m'magazi kuyenera kuchitika pafupipafupi, ndipo kuchuluka kwa insulini ya insulin kumasankhidwa payekha.

Subcutaneous makonzedwe a insulini (mahomoni a jekeseni algorithm akufotokozedwa mwatsatanetsatane mu malangizo ogwiritsira ntchito) amaphatikiza jekeseni wam'mimba, ntchafu, brachial and deltoid minofu, komanso matako. Malo omwe jakisoni amapangidwira amasinthidwe kupewa lipodystrophy.

Ndi kuyambitsa kwa mahomoni m'dera lakunja la peritoneum, mankhwalawa amalowetsedwa mwachangu kuposa jakisoni mbali zina za thupi. Kutalika kwa mphamvu ya timadzi timene timakhudzidwa ndi mlingo, malo a jakisoni, kuchuluka kwa magazi, kutentha kwa thupi, kuchuluka kwa zochita zolimbitsa thupi.

Njira "NovoRapid" imagwiritsidwa ntchito pa infusionsaneous infusions, yomwe imachitika ndi pampu yapadera. Mankhwalawa amalowetsedwa mu anterior peritoneum, koma malo amasinthidwa nthawi ndi nthawi. Ngati pampu ya insulin ikugwiritsidwa ntchito, NovoRapid sayenera kusakanikirana ndi mitundu ina ya insulin yomwe ilimo. Odwala omwe amalandila mahomoni ogwiritsira ntchito kulowetsedwa ayenera kukhala ndi chithandizo chamankhwala ngati chitha kuperewera.

NovoRapid itha kugwiritsidwa ntchito pakukonzekera intravenous, koma njirayi iyenera kuchitika ndi akatswiri odziwa zaumoyo. Pa ulangizi wamtunduwu, ma kulowetsedwa kulowetsedwa nthawi zina amagwiritsidwa ntchito, pomwe insulin imakhala ndi kuchuluka kwa 100 PIECES / ml, ndipo ndende yake ndi 0.05-1 PIECES / ml. Mankhwalawa amathandizira mu 0,9% sodium chloride, 5 ndi 10% dextrose yankho, lomwe limakhala ndi potaziyamu mankhwala ena mpaka 40 mmol / L. Ndalama zomwe zimanenedwa zimasungidwa kutentha kwawofunda osaposa tsiku limodzi. Ndi insulin infusions, muyenera kuperekera magazi pafupipafupi m'magazi.

Momwe mungawerengere kuchuluka kwa insulin?

Kuti mupeze kuchuluka kwa mankhwalawa, muyenera kudziwa kuti insulin imaphatikizidwa, yayitali (yowonjezera), yapakati, yochepa komanso ya ultrashort. Yoyamba matenda a shuga. Zimayambitsidwa pamimba yopanda kanthu. Amawonetsedwa kwa anthu omwe ali ndi matenda a shuga amtundu woyamba 1. Pali anthu omwe amagwiritsa ntchito mtundu umodzi wa insulini okha - wowonjezera. Anthu ena amagwiritsa ntchito NovoRapid pokhapokha kuti achulukane mwadzidzidzi m'magazi. Zovuta zazifupi, zazitali zimatha kugwiritsidwa ntchito nthawi imodzi pochiza matenda ashuga, koma zimaperekedwa nthawi zosiyanasiyana. Kwa odwala ena, kugwiritsa ntchito mankhwala palokha kumathandizira kuti akwaniritse zomwe mukufuna.

Mukamasankha insulin yayitali, zovuta zina ziyenera kukumbukiridwa. Mwachitsanzo, ndikofunikira kuti popanda kubaya joni yochepa komanso zakudya zoyambirira, shuga amakhalanso mumodzimodzi tsiku lonse chifukwa cha insulin yayitali.

Kusankhidwa kwa mlingo wa insulin yayitali kwakhala motere:

• M'mawa, popanda kadzutsa, yeretsani shuga.
• Chakudya chamasana chimadyedwa, ndipo patatha maola atatu, shuga wa m'magazi amatsimikiza. Miyezo ina imachitika nthawi iliyonse musanagone. Patsiku loyamba la kusankha mankhwalawa, vumphani nkhomaliro, koma idyani chakudya chamadzulo.
• Patsiku lachiwiri, chakudya cham'mawa ndi nkhomaliro amaloledwa, koma chakudya chamadzulo sichiloledwa. Shuga, komanso patsiku loyamba, amafunika kuwongoleredwa ola lililonse, kuphatikiza usiku.
• Pa tsiku lachitatu, akupitilizabe miyeso, kudya pafupipafupi, koma osapereka insulin yayifupi.

Zizindikiro zoyenera m'mawa ndi:

• tsiku la 1 - 5 mmol / l,
• patsiku la 2 - 8 mmol / l,
• pa tsiku la 3 - 12 mmol / l.

Zizindikiro za glucose zotere ziyenera kupezeka popanda mahomoni othamangitsa. Mwachitsanzo, ngati m'mawa shuga ali ndi 7 mmol / l, ndipo madzulo - 4 mmol / l, ndiye izi zikuwonetsa kufunikira kochepetsera muyeso wa mahomoni atali ndi 1 kapena 2 ma unit.

Nthawi zambiri, odwala amagwiritsa ntchito fomula ya Forsham kuti adziwe kuchuluka kwa tsiku lililonse. Ngati glycemia ikuchokera ku 150-216 mg /%, ndiye kuti 150 amatengedwa kuchokera pamlingo woyeserera wamagazi ndipo chiwerengero chotsalazo chimagawidwa ndi 5. Zotsatira zake, gawo limodzi la mahomoni ataliatali limapezeka. Ngati glycemia idutsa 216 mg /%, 200 imachotsedwa pa shuga woyezedwa, ndipo zotsatira zake zimagawidwa ndi 10.

Kuti mudziwe kuchuluka kwa insulin yayifupi, muyenera kuyeza kuchuluka kwa shuga sabata yonse. Ngati zinthu zonse zatsiku ndi tsiku zili zabwinobwino, kupatula madzulo, ndiye kuti insulin yochepa imangoperekedwa musanadye chakudya chamadzulo. Ngati shuga azidumphira chakudya chilichonse, ndiye kuti jakisoni amaperekedwa musanadye.

Kuti mudziwe nthawi yomwe mahomoni amayenera kuperekedwera, shuga ayenera kuyesedwa mphindi 45 asanadye. Kenako, muziwongolera shuga mphindi zisanu zilizonse kufikira mulingo wake wafika 0,3 mmol / l, mutatha kudya. Njirayi imalepheretsa kuyamba kwa hypoglycemia. Ngati pambuyo pa mphindi 45 shuga sichepa, muyenera kudikirira ndi chakudya mpaka glucose atatsikira pamlingo womwe mukufuna.

Kuti mudziwe mtundu wa insulin ya ultrashort, anthu omwe ali ndi matenda amtundu wa 1 ndi mtundu wa 2 amalangizidwa kuti azitsatira zakudya sabata imodzi. Yang'anani kuchuluka kwa zakudya zomwe amadya. Musapitirire kuchuluka kwa chakudya chololedwa. Muyeneranso kuganizira zolimbitsa thupi za wodwalayo, mankhwala, kukhalapo kwa matenda osachiritsika.

Ultrashort insulin imayendetsedwa kwa mphindi 5-15 musanadye. Momwe mungawerengere mlingo wa NovoRapid insulin pamenepa? Tiyenera kukumbukira kuti mankhwalawa amachepetsa mphamvu ya glucose nthawi 1.5 mopitilira malo ake achidule. Chifukwa chake, kuchuluka kwa NovoRapid ndi 0,4 peresenti ya homoni yochepa. Muyezo ungadziwike makamaka pokhapokha poyesa.

Mukamasankha mlingo wa insulin, kuchuluka kwa matendawa kuyenera kuganiziridwanso, komanso kuti kufunika kwa matenda ashuga aliwonse m'thupi la munthu sikupitirira 1 U / kg. Kupanda kutero, bongo amatha kuchitika, zomwe zimayambitsa zovuta zingapo.

Malamulo oyenera kudziwa mtundu wa odwala matenda ashuga:

• Kumayambiriro kwa matenda a shuga 1, mankhwalawa sayenera kupitirira 0,5 U / kg.
• Mtundu woyamba wa shuga, womwe umayang'aniridwa ndimadwala kwa chaka chimodzi kapena kupitilira, kuchuluka kwa insulin komwe kumayendetsedwa ndi 0.6 U / kg.
• Ngati matenda amtundu wa shuga 1 amaphatikizidwa ndi matenda oopsa angapo ndipo ali ndi zizindikiro zosakhazikika zamagulu am'magazi, kuchuluka kwa timadzi ndi 0.7 U / kg.
• Mu matenda a shuga a mellitus, kuchuluka kwa insulin ndi 0,8 U / kg.
• Ngati matenda a shuga ali ndi ketoacidosis, ndiye kuti pafupifupi 0,9 U / kg ya mahomoni amafunikira.
• Pa nthawi yoyembekezera, mayi wachitatu trimester amafunika 1.0 U / kg.

Kuti muwerenge mlingo umodzi wa insulini, mlingo wa tsiku ndi tsiku uyenera kuchulukitsidwa ndi kulemera kwa thupi ndikugawidwa ndi awiri, ndipo chizindikiro chomaliza chikuyenera kuzunguliridwa.

Kugwiritsa ntchito mankhwala "NovoRapid Flexpen"

Kukhazikitsidwa kwa hormone kumatha kuchitika pogwiritsa ntchito cholembera "NovoRapid Flexpen." Imakhala ndi zolembera zamtundu ndi chothandizira. Mlingo wa insulini womwe umayendetsedwa kuchokera ku 1 mpaka 60 mayunitsi, gawo limodzi la syringe ndi 1 unit. Mu mankhwalawa "NovoRapid" mankhwalawa amagwiritsidwa ntchito TM "Novotvist" kapena "Novofine" kutalika kwa 8 mm. Ngati mugwiritsa ntchito cholembera, kumbukirani kuti: nthawi zonse muyenera kukhala ndi pulogalamu yopanda jekeseni nanu - kuti syringe itawonongeka kapena itayika.

Musanalowetse hormone ndi cholembera, muyenera:

• Werengani malembedwewo ndikuonetsetsa kuti NovoRapid ndiye insulini yomwe mukufuna.
• Chotsani kapu ku cholembera.
• Chotsani chomata chomwe chili pa singano yotayika.
• Vulani singano m'manja. Pangofunika singano yatsopano pa jekeseni iliyonse kuti muchepetse kukula kwa mabakiteriya. Singano siyenera kuti ikhale yopindika kapena kuwonongeka.
• Kuti mupewe jakisoni mwangozi pa singano mutatha kuperekera insulin, kapu sikuvalira.

Cholembera cha NovoRapid chingwe chitha kukhala ndi mpweya wochepa mkati. Kuti thovu la okosijeni lisadziunjike, ndipo mulingo woyamwa umaperekedwa molondola, malamulo ena ayenera kutsatiridwa:

• Imbani 2 PESCES ya mahormone potembenuzira mlingo wosankha.
• Ikani cholembera pakati ndi singano ndikukoka cartridge ndi chala chanu. Chifukwa chake ma thovu am'mlengalenga amasamukira kudera lapamwamba.
• Mukugwira syringe ya FlexPen mozondoka ndi singano, kanikizani batani loyambira njira yonse. Osankha dosing panthawiyi abwerera ku "0" malo. Dontho limodzi la mahomoni limawonekera pa singano. Ngati izi sizingachitike, njirayi ikhoza kubwerezedwa kasanu ndi kamodzi. Ngati insulin singayende, ndiye kuti syringe ndi yopanda tanthauzo.

Musanakhazikitse mlingo, muyenera kuwonetsetsa kuti chosankha cha dosing chili mu "0". Chotsatira, muyenera kuyimba manambala omwe amafunikira, kuchuluka kwa mankhwalawo kumayendetsedwa ndi osankhidwa mbali zonse ziwiri. Mukakhazikitsa mlingo, muyenera kusamala ndikuyesera kuti musagunde mwangozi batani loyambira, apo ayi kutulutsidwa kwa mahomoni kumachitika. Ndikosatheka kukhazikitsa njira yoposa yomwe ili pokonzekera "NovoRapid". Komanso, musagwiritse ntchito muyeso wotsalira kuti mudziwe kuchuluka kwa mahomoni.

Panthawi ya insulin, njira yolimbikitsidwa ndi adotolo imatsatiridwa. Kuti mupeze jakisoni, dinani batani loyambira. Gwirani mpaka mlingo wosankha uli mu "0". Pa jakisoni, batani loyambira lokha limachitika. Munthawi yoyenera ya kuzungulira kwa chisonyezo, kuperekera kwa insulin sikuchitika.

Pambuyo pa jekeseni, singano pansi pa khungu iyenera kumenyedwa kwa masekondi ena asanu ndi limodzi, osatulutsa batani loyambira. Chifukwa chake mlingo wa insulin umayambitsidwa kwathunthu. Pambuyo pa jekeseni, singanoyo imatumizidwa kumtunda wakunja, ndipo ikalowa, imasulidwa ndikuitaya, ndikusamala. Kenako syringe imatsekedwa ndi chipewa. Singano imachotsedwa pakatha jekeseni iliyonse ndipo singathe kusungidwa ndi cholembera. Kupanda kutero, madzimadzi amatha kutayikira, zomwe zingayambitse kuyambitsa kwa cholakwika. Malangizo ogwiritsira ntchito akufotokozerani zambiri za momwe mungabayire insulin ya NovoRapid.

Zotsatira zoyipa

Mankhwala "NovoRapid" amatha kuyambitsa zovuta zingapo. Ichi ndi hypoglycemia, chomwe chimadziwonetsera mu thukuta lokwanira, khungu, mantha, malingaliro osaganizira, nkhawa, kunjenjemera, kufooka m'thupi, kusayenda bwino komanso kutsitsidwa ndende. Chizungulire, njala, kusagwira bwino ntchito kwa zida zowonekera, mseru, mutu, tachycardia kumachitikanso. Glycemia imatha kuyambitsa khungu, ziwopsezo, kusokonekera kwa ubongo ndi ntchito.

Nthawi zambiri, odwala amalankhula za mawonekedwe amtunduwu monga urticaria, totupa. Mwina kuphwanya m'mimba ndi matumbo, mawonekedwe a angioedema, tachycardia, kufupika kwa mpweya. Odwala adakumana ndi kuchepa kwa kuthamanga kwa magazi.

Mwa zina zomwe zimachitika mderalo, kuyabwa m'malo obaya, khungu, komanso kutupa kwa khungu. Nthawi zambiri, zizindikiro za lipodystrophy zachitika. Mankhwalawa amatha kuyambitsa edema koyambirira kwa chithandizo, komanso kuphwanya Refraction.

Madokotala amati mawonetseredwe onse ndi osakhalitsa ndipo amawonekera makamaka mwa odwala omwe amadalira mlingo wa mankhwala ndipo amayamba chifukwa cha mankhwala omwe amapanga insulin.

Ngati mahomoni sagwira ntchito, ndiye kuti nthawi zonse mutha kusintha mankhwala a NovoRapid Flexpen. Ma analogues, kumene, ayenera kusankhidwa ndi adokotala. Zotchuka kwambiri ndi:

Mtengo wa mahormone

Mankhwala a NovoRapid amamasulidwa mosamala malinga ndi zomwe dokotala wanena.Mtengo wa makatiriji a Penfill asanu ndi pafupi 1800 rubles. Mtengo wa hormone Flexpen ndi ma ruble 2,000. Phukusi limodzi lili ndi zolembera zisanu za Novorapid insulin. Mtengo kutengera nambala yogawa ingasiyane pang'ono.

Pofuna kuchiza matenda a shuga, akatswiri a zamankhwala apanga mitundu ingapo ya mankhwala osiyanasiyana. Insulin ndiye mankhwala othandiza kwambiri pochiza matenda. Monga mankhwala ambiri, amagawika m'magulu angapo a mankhwala. Yothandiza kwambiri ndi insulin Novorapid. Pali mitundu yosiyanasiyana ya Novorapid insulin: Flekspen, Aspart.

Zomwe madotolo amati pa matenda ashuga

Doctor of Medical Science, Pulofesa Aronova S. M.

Kwa zaka zambiri ndakhala ndikuphunzira za zovuta za DIABETES. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinology Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 100%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipilira mtengo wonse wa mankhwalawo. Ku Russia ndi mayiko a CIS odwala matenda ashuga kale atha kupeza mankhwala ZAULERE .

Malangizo ogwiritsira ntchito

Mukabayidwa NovoRapid, monga mtundu wina wa insulin, muyenera kutsatira zakudya.

Anthu ambiri omwe ali ndi matenda ashuga omwe amaba jakisoni wofulumira amakhala kuti sizingatheke kupewa hypoglycemia. M'malo mwake, izi siziri choncho. Mutha kusunga shuga wokhazikika ngakhale ndi matenda oopsa a autoimmune. Ndipo makamaka, ndi matenda a shuga a 2 ochepa. Palibe chifukwa chakuwonjezera kuchuluka kwa shuga m'magazi anu kuti mudzilimbitse nokha motsutsana ndi hypoglycemia yoopsa.Onerani kanema pomwe Dr. Bernstein akufotokoza nkhaniyi ndi bambo wa mwana yemwe ali ndi matenda a shuga 1. Phunzirani momwe mungasinthire zakudya zopatsa thanzi komanso mulingo wa insulin.

Ambiri odwala matenda ashuga akuyang'ana njira zogulira Novorapid insulin kuchokera m'manja mwawo, malinga ndi zolengeza zachinsinsi. Tsamba la endocrin-patient.com limalimbikitsa kwambiri kuti musatero. Insulin ndi mahomoni osalimba kwambiri. Zimasokoneza ndikuphwanya pang'ono malamulo osungira. Kuphatikiza apo, mtundu wake sungadziwike ndi maonekedwe. Wopaka insulin Novorapid ukhoza kukhala womveka bwino.

Kugula ndi manja anu, mukuyenera kuti muwonongedwe kapena kukhala ndi insulini yabodza. Nthawi yomweyo, mukuwononga nthawi ndi ndalama zanu, mukuthana ndi vuto lanu la matenda ashuga. Gulani Novorapid ndi mitundu ina ya insulini yokha mumasitolo odalirika, odalirika. Pewani zotsatsa zachinsinsi zogulitsa mankhwala ofunika.

Novorapid - machitidwe a insulin ndi chiyani?

Novorapid ndi mankhwala a ultrashort. Asayansi adasintha pang'ono kapangidwe kake poyerekeza ndi insulin wamba yamunthu, kuti imayamba kugwira ntchito mwachangu, atangolowa jakisoni. M`pofunika kudya pasanathe mphindi 10-20 pambuyo kukhazikitsa mankhwala. Ichi chingakhale insulin yothamanga kwambiri padziko lapansi. Ngakhale jakisoni wa mahomoni amachita mosiyanasiyana kwa odwala matenda ashuga onse. Wina Humalog angaoneke mwachangu.

Mungamayike bwanji?

Onani mtundu wanu 1 pulogalamu yoyeserera matenda ashuga kapena ndondomeko ya sitepe yachiwiri yothetsera matenda a shuga. Gwiritsani ntchito moyenera insulini yothamanga ngati mbali imodzi ya njira zotithandizira kukhalabe ndi shuga. Pochiza matenda a shuga, kudya zakudya zopatsa thanzi kumatenga gawo lalikulu, kenako kusankha mitundu ya insulin yomwe imagwiritsidwa ntchito, kusankha kwa mapiritsi ndi ndondomeko ya jakisoni.

Kwa odwala matenda ashuga omwe amatsatira zakudya zama carb zotsika, Novorapid ndi analogues sakhala abwino kwenikweni ngati insulin isanadye. Chifukwa zimagwira mwachangu kuposa zomwe zaloledwa kumizidwa. Pakhoza kukhala magawo a shuga wamagazi ochepa (hypoglycemia), komanso kudumphira m'magulu a shuga. Zitha kukhala zoyenera kugwiritsa ntchito insulin yayifupi, monga Actrapid. Komanso, zimawononga zochepa.

Ndikofunikira kwa masiku angapo kuti muzindikire za shuga. Tsimikizani musanadye chakudya chomwe mukufuna jakisoni wa insulin yofulumira.Zitha kuzindikirika kuti palibe chifukwa chobayira Novorapid katatu patsiku, koma jakisoni 1-2 ndikokwanira kapena mutha kuchita popanda iwo. Kuti mumve zambiri, onani nkhani ya "Kusankha mankhwala olimbitsa mtima a insulin musanadye". Jakisoni wa Novorapid amachitika mphindi 10-20 asanadye. Osayesa kulumpha chakudya mutatha kupaka insulin. Idyani motsimikiza.

Zizindikiro zogwiritsidwa ntchito

Amalembedwa kwa anthu omwe ali ndi matenda a shuga mellitus a madigiri osiyanasiyana. Yavomerezedwa kuti igwiritsidwe ntchito kwa zaka ziwiri.

Zotsatira za pharmacological

Novorapid amalumikizana ndi ma cell membrane receptors, zomwe zimalimbikitsa kupanga kwa mahomoni achibadwa.

Pogwiritsa ntchito mankhwalawa, kuchepa kwa shuga m'magazi ndikotheka, izi nthawi zambiri zimayambitsidwa ndi:

• mayendedwe ndikupanga insulin m'mwazi wa wodwalayo,
• mayamwidwe a mankhwala ndi thupi
• utachepa chiwindi shuga.

Mukamamwa mtundu uliwonse wa insulin, yeretsani magazi anu kuti mupewe matenda ashuga.

Ndili chifukwa cha zochita zake kuti mtundu wa insulin uwu ndi wothandiza kwambiri.

Mlingo wa mankhwalawa umaperekedwa kwa wodwala aliyense. Mlingo wamba wa azakhali ndi akulu ndi: 0.5-1 pa kilogalamu ya thupi. Kuti mudziwe zamankhwala ndikupereka mankhwala, muyenera kuwona dokotala. Katswiriyu adzakupatsirani matenda oyenera ndikuwapatsani mankhwala, poganizira moyo wanu.

Samalani

Malinga ndi WHO, chaka chilichonse padziko lapansi anthu 2 miliyoni amafa chifukwa cha matenda ashuga komanso zovuta zake. Pokhapokha pakhale thandizo loyenerera la thupi, matenda ashuga amabweretsa mavuto osiyanasiyana, pang'onopang'ono kuwononga thupi la munthu.

Mavuto omwe amakonda kwambiri ndi awa: matenda a shuga a shuga, nephropathy, retinopathy, trophic zilonda zam'mimba, hypoglycemia, ketoacidosis. Matenda a shuga amathanso kuyambitsa kukula kwa zotupa za khansa. Pafupifupi nthawi zonse, wodwala matenda ashuga amwalira, akulimbana ndi matenda opweteka, kapena amasintha kukhala munthu weniweni wolumala.

Kodi anthu odwala matenda ashuga amatani? Endocrinological Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga chida chomwe chimachiritsa kwathunthu matenda a shuga.

Pulogalamu ya Federal "Health Health Nation" ikuchitika, mkati mwa momwe mankhwalawa amaperekedwa kwa aliyense wokhala ku Russian Federation ndi CIS ZAULERE . Kuti mumve zambiri, onani tsamba lovomerezeka la MINZDRAVA.

Pazifukwa zina, dokotala angasinthe mlingo:

• zochita zolimbitsa thupi,
• Matenda ena opweteka omwe amachulukitsa Zizindikiro za matenda ashuga,
• kukulira vuto la wodwala,
• kumwa mankhwala, gulu lina la mankhwala.

Mankhwalawa amaperekedwa pansi pakhungu pogwiritsa ntchito syringe yapadera. Ogwira ntchito zachipatala amatha kupereka insulin kudzera m'mitsempha.

Gwiritsani ntchito mosamala

Mankhwala aliwonse amawonetsa, omwe ayenera kugwiritsidwa ntchito mosamala, kapena kuchotsera kwathunthu:

• katoni iliyonse imagwiritsidwa ntchito kamodzi. Sizoletsedwa kugwiritsa ntchito mankhwala omwe ali kale kale. Ndi jakisoni watsopano, gwiritsani ntchito syringe yonyansa,
• osagwiritsa ntchito mankhwalawa ngati yankho lake ndi mitambo kapena lili ndi mthunzi,
• kugwiritsa ntchito insulin mwachangu, gwiritsani ntchito syringe U100.

Njira zogwiritsira ntchito

Novorapid lakonzedwa kuti subcutaneous makonzedwe. Mwina kulowa mtsempha wamkati, pakubaya kwa katswiri woyenera. Pakukhazikitsa insulin, malo otsatirawa ndi oyenera kwambiri:

Ikani insulin pansi pa khungu malinga ndi luso lomwe dokotala wakupangirani.

Owerenga athu amalemba

Mutu: Matenda a shuga apambana

Ku: my-diabet.ru Administration

Ndili ndi zaka 47, ndinapezeka kuti ndili ndi matenda ashuga a 2. M'masabata angapo ndinapeza pafupifupi 15 kg. Kutopa nthawi zonse, kugona, kumva kufooka, kuwona kunayamba kukhala pansi. Nditakwanitsa zaka 66, ndinali ndikumenya insulin yanga, zonse zinali zoipa kwambiri.

Nayi nkhani yanga

Matendawa adapitilirabe, kukomoka kwakanthawi kunayamba, ambulansi imandibwezera kuchokera kudziko lina. Nthawi zonse ndimaganiza kuti nthawi ino ikhala yomaliza.

Chilichonse chinasintha mwana wanga wamkazi atandilola kuti ndiwerenge nkhani imodzi pa intaneti. Simungayerekeze m'mene ndimamuyamikirira. Nkhaniyi inandithandiza kuthana ndi matenda ashuga, omwe amati ndi osachiritsika. Zaka 2 zapitazi ndidayamba kusuntha kwambiri, nthawi yamasika ndi chilimwe ndimapita kumayiko tsiku lililonse, timakhala ndi moyo wachangu ndi amuna anga, timayenda maulendo ataliatali. Aliyense amadabwitsidwa ndimomwe ndimakwanitsira chilichonse, komwe ndimatha mphamvu zambiri, sakhulupirira kuti ndili ndi zaka 66 zakubadwa.

Ndani akufuna kukhala ndi moyo wautali, wamphamvu komanso kuiwalako za matenda oyipawa kwamuyaya, tengani mphindi 5 ndikuwerenga nkhaniyi.

Pitani pa nkhaniyi >>>

Novorapid imasungidwa pa kutentha kwa madigiri 2-8. Ndikofunika kuyika mankhwalawo mufiriji, koma pewani kuzizira. Chotsani chiwonetsero cha dzuwa mwachindunji ndikuyang'anira tsiku lomwe lisungidwe.

Insulin

Kwa inshuwaransi ya Aspart, malangizo amomwe mungagwiritsire ntchito. Kuchiwona, mudzapewa mavuto ambiri okhudzana ndi kutenga "Astarta".

Mtundu wa insulin ndi madzimadzi a magawo awiri okhala ndi insulin yotulutsa dzuwa ndi 30% ndi galasi la crystalline ndi 70%. Aspart ndi yofanana ndi insulin yaumunthu, koma imakhala yochepa. Ili ndi adsorption yayikulu, yomwe imakupatsani mwayi kusintha mwachangu, ngakhale mawonekedwe ovuta.

Zizindikiro zogwiritsidwa ntchito

• Matenda opatsirana omwe amayenda ndi matenda ashuga.
• Matenda a shuga a degree yoyamba ndi yachiwiri.

Kodi jakisoni wa mankhwalawa amatenga nthawi yayitali bwanji?

Mlingo uliwonse wa Novorapid wa insulin umatenga pafupifupi maola anayi. Palibenso chifukwa choyezera shuga pakatha maola awiri jakisoni, chifukwa munthawi imeneyi mankhwalawa sangakhale ndi nthawi yochita mokwanira. Yembekezani maola 4, kenako kuyeza glucose wamagazi anu ndikubaya jekeseni yotsatira ngati pakufunika. Ndikwabwino kusalola milingo iwiri ya insulin kuti ichite munthawi yomweyo mthupi. Kuti muchite izi, perekani Novorapid mosinthana ndi maola osachepera anayi.

Zoyenera kuchita ngati Novorapid samachepetsa shuga?

Mwambiri, mankhwalawa adachepa chifukwa chophwanya malamulo osungira insulin. Osayesa kubayira insulin yomwe inaipitsidwa mu Mlingo waukulu kuti chiyembekezo chitha kugwira ntchito. Izi ndi zakupha. Tayetsani katoni kapena botolo lanu lenileni, yambani kugwiritsa ntchito yatsopano. Yembekezerani maola 4-5 kuchokera nthawi yomwe jekeseni wapitayo. Pambuyo pokhapokha pangani mwatsopano insulin. Phunzirani malamulo osunga mankhwala a mahomoni ndikuwatsata mosamala.

Kodi ndingapeze kuti kufanizira kwa Novorapid ndi Levemir insulin?

Novorapid ndi Levemir si mitundu yonse yofanana ya insulin. Sangafanane, chifukwa amathetsa mavuto osiyanasiyana pakulamulira matenda ashuga. Zitha kugwiritsidwa ntchito nthawi yomweyo. Ambiri odwala matenda ashuga amachita izi. Mukudziwa kale kuti Novorapid ndi insulin yotsalira-yochepa. Amamenyedwa musanadye, komanso pangozi zadzidzidzi mukafunikira kuthamangitsa shuga wambiri.

Levemir ndi mankhwala omwe akhala akuchita kwa nthawi yayitali. Imagwiritsidwa ntchito kotero kuti pali maziko a insulin m'magazi mosalekeza maola 24 patsiku. Izi zimapangitsa shuga m'magazi komanso zimalepheretsa kuchepa kwa minofu ndi ziwalo zamkati. Levemir sanapangidwe kuti achepetse kuchuluka kwa glucose pambuyo chakudya.

Mtundu wa 1 ndi matenda a shuga a 2, ovuta kwambiri, mitundu iwiri ya insulin iyenera kugwiritsidwa ntchito nthawi imodzi - yayitali komanso yochepa (ultrashort). Ikhoza kukhala Levemir ndi Novorapid kapena analogu omwe amapikisana nawo. Mankhwala omwe analimbikitsidwa omwe alembedwa mu "Mitundu ya insulin ndi zomwe amachita". Samalani ndi inshuwaransi yayitali Treshiba, yomwe m'njira zambiri ndiyabwino kuposa Levemir.

Novorapid insulin analogues ndi Humalog ndi Apidra. Amapangidwa ndi makampani opanga mankhwala. Mitundu yonse ya insulini ndiyofanana kwambiri.Dr. Bernstein akuti Humalog ndiyosachedwa komanso yamphamvu kuposa Apidra ndi Novorapid. Komabe, m'mabungwe a matenda ashuga, zofalitsa zambiri zimatsutsa izi.

Pochita masewera olimbitsa thupi, kusiyana pakukonzekera mpikisano wa insulin sikofunika kwambiri. Monga lamulo, odwala matenda ashuga amapaka insulin yomwe amawapatsa kwaulere. Popanda kufunikira kwakukulu, ndibwino kuti musasinthe kuchokera ku Novorapid kupita ku imodzi mwazofanana. Kusintha koteroko kumakulitsa shuga wamagazi kwa masiku angapo kapena masabata.

Kungakhale koyenera kusinthira ku insulin yochepa ya anthu. Mwachitsanzo, pa Actrapid. Malangizowa ndi a anthu odwala matenda ashuga omwe amadya kwambiri. Mbiri ya zochita za insulin yocheperako imagwirizana ndi kuchuluka kwa zinthu zomwe zimaloledwa ndikuvomerezedwa. Ndipo Novorapid ndi mankhwala ena a ultrashort amachita zinthu mwachangu kwambiri.

NovoRapid pa nthawi yapakati

Insulin Novorapid itha kugwiritsidwa ntchito kuwongolera shuga yayikulu m'magazi mwa amayi. Sichimabweretsa mavuto apadera kwa mayi kapena kwa mwana wosabadwayo. Chonde dziwani kuti Novorapid ndi mankhwala a ultrashort. Imagwira mwachangu komanso mwamphamvu kuposa insulin yokhazikika. Chiwopsezo cha hypoglycemia (shuga wotsika wamagazi) kwa wodwalayo chimawonjezeka, makamaka mu theka loyambirira la mimba, pamene chidwi chokhudza thupi cha insulin chiri pamwamba kwambiri.

Izi sizitanthauza kuti muyenera kusiya kugwiritsa ntchito mankhwala a Novorapid insulin panthawi yapakati. Mankhwala omwe atchulidwa angagwiritsidwe ntchito ngati akuwuzani dokotala. Onetsetsani kuti mayi woyembekezera akumvetsetsa kuchuluka kwake. Simuyenera kukhala aulesi kuyeza shuga la magazi anu kangapo tsiku lililonse. Sinthani mlingo wanu wa insulin malinga ndi izi. Mupeza zambiri zosangalatsa mu nkhani za Pregnant Diabetes and Gestational Diabetes. Nthawi zambiri, mukamadya zakudya zoyenera, mutha kuchita popanda Novorapid insulin ndi mankhwala ena amphamvu aifupi.

Ndemanga 6 pa NovoRapid

Moni Posachedwa tidwala ndi matenda a shuga 1, adayamba kuthandizidwa ndi insulin. Tikuphunzira tsamba lanu, tsopano tikungosintha chakudya cha banja lonse, koma zambiri zikuyenera kuwonedwa. Mwachitsanzo, zoterezi. Mwanayo ali ndi zaka 8. Adayang'ana shuga ndi glucometer nthawi ya 22:00 - adawonetsa 16.2. Anapanga NovoRapid 2 mayunitsi. Patatha ola limodzi, adayesanso - zotsatira zake zinali 17.3. Chifukwa chiyani glucose adakwera? Kodi jakisoni wofulumira wa insulin sikugwira ntchito?

Mwanayo ali ndi zaka 8. Adayang'ana shuga ndi glucometer nthawi ya 22:00 - adawonetsa 16.2. Anapanga NovoRapid 2 mayunitsi. Patatha ola limodzi, adayesanso - zotsatira zake zinali 17.3. Chifukwa chiyani glucose adakwera?

Shuga wa mwana wanu sanaphuke, koma amakhalabe momwe analili, kuphatikiza cholakwika ndi chiwerengero. Zachidziwikire, izi sizabwino.

Kwa mwana wazaka 8, mlingo wa mayunitsi awiri a insulin 2 ndiwokwera kwambiri. Ngati sichinagwire ntchito, mankhwalawo amatha kuwonongeka.

Moni Ndikufuna thandizo lanu - kulipiritsa matenda a shuga mwa mwana wanga wamkazi wazaka 10. Wadwala kwa zaka 2. Insulin: yayitali - Protafan, chakudya - NovoRapid. Mlingo: Protafan m'mawa ndi usiku kwa 2 PIECES, NovoRapid - 2 PESCES asanadye chilichonse. Kuyambira chaka chatsopano, tayamba kudumphadumpha koopsa m'masamba osiyanasiyana kuyambira 2-3 mpaka 20 mkati mwa maola 2-3. Mwanayo amadandaula kuti wadwala mutu, nthawi zina ngakhale miyendo yake simamumvera. Ndi shuga a 1.8, panali ma cramp. Chifukwa chiyani kudumpha? Timatsata zakudya, timaganizira za mkate. Zoyenera kuchita.

Chifukwa chiyani kudumpha? Timatsata zakudya, timaganizira za mkate.

Poyerekeza kutchulidwa kwa magawo a mkate, mumatsatira zakudya zosayenera (zosayenera), chifukwa chake mavuto onse.

Poyamba, zonse zidali bwino, chifukwa mwana amasungabe zotsalira za insulin yake. Izi zimatchedwa phwando laukwati. Tsopano zatha - ndipo zotsatira za chithandizo chamankhwala cha shuga chikuwonekera muulemerero wake wonse.

Lowani gulu lathu.m'lingaliro, banja lonse liyenera kusamutsidwa ku chakudya chochepa cha carb - http://endocrin-patient.com/dieta-pri-saharnom-diabete/ - ndikuwonetsetsa. Fotokozerani mwana wamkazi zomwe zimabweretsa chifukwa chodya zakudya zovulaza.

Protafan m'mawa ndi usiku m'magawo awiri, NovoRapid - m'magawo awiri chakudya chisanachitike.

Mankhwalawa onse siabwino, ndikulimbikitsidwa kuti muthane ndi mitundu ina ya insulini, kuti mumve zambiri onani http://endocrin-patient.com/vidy-insulina/

Ndikutsimikizira kuti popanda kusinthira zakudya zamafuta ochepa, izi sizigwira ntchito.

Amuna anga adadwala kwa zaka zopitilira 10, miyezi isanu ndi umodzi yapitayo adasinthira ku NovoRapid ndi Levemir insulin, timawatenga monga adalangizidwa ndi dokotala. Mwamuna amapitilira masewera katatu pamlungu: kusambira, volleyball. Timayesetsa kusunga zakudya. Koma pazifukwa zina amakhala ndi shuga wamagazi kwambiri - kwinakwake 11-12, nthawi zina 13. Mwina upatseni upangiri.

Malangizo - werengani mosamala zida zomwe zili patsamba lino musanalembe ndemanga.

Kupanga ndi mawonekedwe a kumasulidwa

Mu 1 ml ya insulin yankho lili:

• Zogwira pophika: 100 IU aspart (ofanana ndi 3.5 mg)
• Zowonjezera: glycerol, phenol, metacresol, zinc chloride, sodium chloride, sodium hydroxide, hydrochloric acid, madzi d / ndi zina.

Mankhwala omwe amapangidwa ndi madzi a s / c ndi jekeseni wa iv ndi njira yosapangidwa kapena yocheperako pang'ono chikasu popanda kuyimitsidwa. Amayikamo bokosi lamagalasi la cholembera chomwe angathe kuyambiranso. Mu mankhwala 1 - 3 ml ya aspart. Phukusi la makatoni akuda - 5 n-zolembera, kalozera wamankhwala.

Kuphatikiza pa syringe pensulo, ma asparts amakhalanso amtundu wa makatiriji payokha. Ipezeka pansi pa dzina la Novorapid Penfill.

Kuchiritsa katundu

Mankhwala ndi analogue a insulin ya anthu mwachangu komanso yochepa. Poyerekeza ndi ma insulle ena osungunuka, spartt imatha kutsika shuga: mphamvu yake yokwanira imayamba pakatha maola 4 pambuyo pa jekeseni, ndipo zomwe zili ndi shuga zimakhala zotsika. Koma pambuyo pa utsogoleri pakhungu, nthawi yake imakhala yofupikitsa poyerekeza ndi insulin ya anthu.

Wodwalayo amamva mpumulo pambuyo pa Novorapid Flexpen pambuyo pa mphindi 10-15, mphamvu ya mankhwalawa imatha maola atatu mpaka asanu.

Kafukufuku wokhudzana ndi zamankhwala wokhudzana ndi mankhwalawa glycemia mu mtundu 1 odwala matenda ashuga awonetsa kuti pambuyo povutirapo, chiopsezo cha hypoglycemia usiku ndizochepa kwambiri poyerekeza ndi mankhwala ofanana ndi omwe adachokera kwa anthu. Pafupipafupi milandu imafanana ndizinthu izi.

Hypoglycemic zotsatira za mankhwala zimatheka chifukwa cha insulin - chinthu chomwe chimafanana ndi insulin. Aspart imapangidwa ndi genetic engineering, yomwe imapereka mwayi woloza proline ndi aspartic acid pamavuto a Saccharomyces cerevisiae. Chifukwa cha izi, aspart imalowa mkati mwa ziwalo zamagetsi ndi kuthamanga kwambiri ndipo imakhala ndi kufunika.

Zokhudza kugwiritsa ntchito insulin

Mtengo Wapakati: (5 ma PC.) - 1852 ma ruble.

Ngati wodwala matenda ashuga amayenera kupita kumalo okhala ndi nthawi yosiyana, ayenera kufunsiratu momwe amamwa

Ngati Novorapid Flexpen sanagwiridwe ntchito mokwanira kapena pazifukwa zina wodwalayo asiya kuzipereka, izi zitha kupangitsa matenda a hyperglycemia ndi matenda ashuga a ketoacidosis. Matenda a diabetes 1 omwe amakonda kwambiri izi. Zizindikiro zimayamba pang'onopang'ono, kukulira. Mutha kuweruza kusowa kwa boma ndi nseru, kusanza, kugona, khungu lowuma komanso zimagwira pakamwa. Hyperglycemia amathanso kuweruzidwa ndi fungo la acetone pakupuma.

Ngati hypoglycemia ikukayikira, chithandizo choyenera chikuyenera kuthandizidwa mwachangu, mwinanso kuwonjezeka kwa matendawa kungayambitse imfa ya wodwala matenda ashuga. Tiyenera kudziwa kuti chithandizo cha insulin chambiri chimatha kupotoza zomwe zimachitika mu hypoglycemia.

Mu anthu odwala matenda ashuga, mwa kuwongolera kagayidwe kachakudya, zovuta zamatenda zimachepetsedwa ndikupita patsogolo pang'onopang'ono. Chifukwa chake, ndikofunikira kuchita njira zoyenera zothetsera kagayidwe kachakudya, kuphatikizapo kuwunika kuchuluka kwa shuga m'magazi.

Tiyenera kudziwa kuti njira za hypoglycemic zimapangidwa mwachangu ngati wodwala matenda ashuga ali ndi matenda ofanana kapena akuchiritsidwa ndi mankhwala omwe amalepheretsa chakudya. Ndi concomitant pathologies, makamaka ngati ali ochokera ku matenda opatsirana, kufunika kwa mankhwalawa kumawonjezeka. Ngati wodwala matenda ashuga akukumana ndi chiwindi komanso / kapena impso, ndiye kuti kufunikira kwa insulin kumachepa.

Pambuyo pa kusintha kwa odwala matenda ashuga mitundu ina ya mankhwalawo, zizindikiro zoyambirira za hypoglycemia zitha kupotozedwa kapena kuchepera mphamvu, poyerekeza ndi insulin yomwe kale idagwiritsidwa ntchito.

Kusintha kwa mtundu wina wa insulin kuyenera kuyang'aniridwa ndi madokotala. Kusintha kwa mankhwalawa kungafunike osati posintha mtundu wa mankhwala, komanso wopanga, njira yopangira.

Mlingo uyenera kusinthidwa ngati wodwala matenda ashuga asintha zakudya zina, anasintha kudya, ayamba kapena atasiya kuchita masewera olimbitsa thupi. Wodwala ayenera kukumbukira kuti kudumpha chakudya kapena kuchita masewera olimbitsa thupi mosakonzekera kungayambitse hypoglycemia.

Kuyang'aniridwa moyenera kwa glycemic kumachepetsa chiopsezo cha kufalikira kwa matenda ashuga. Kuchita insulin kwambiri komanso kuwongolera msanga m'mimba kumatha kuyipa kwakanthawi mu retinopathy.

Kodi Novorapid Flexpen insulin imakhudza momwe zimachitikira

Mikhalidwe yokhala ndi hypo- ndi hyperglycemia imakhudza kuthamanga kwa kayendedwe komanso kutha kuyang'ana kwambiri, zimathandizira kuti pakhale zochitika zoopsa mukamayendetsa magalimoto kapena machitidwe ovuta. Odwala ayenera kuchitapo kanthu pasadakhale kuti ateteze kukula. Izi ndizowona makamaka kwa omwe ali ndi matenda ashuga omwe zizindikiro za matenda amaphatikizika, amawonekera pang'onopang'ono. Muzochitika izi, odwala matenda ashuga amalimbikitsidwa kuti aganizire zosiya mtundu uwu.

Kuchita mankhwala osokoneza bongo

Tiyenera kudziwa kuti mankhwalawa amatha kusokoneza magazi a magazi. Chifukwa chake, ngati munthu wodwala matenda ashuga akukakamizidwa kumwa mankhwala ena, ayenera kudziwitsa adotolo za iwo pasadakhale kuti adziwe momwe angagwiritsire bwino jakisoni.

• Mankhwala osokoneza bongo omwe amachepetsa kufunikira kwa insulin: Mankhwala ochepetsa shuga a pakamwa, maMAO, beta-blockers, mankhwala osokoneza bongo a magulu a salicylates ndi sulfanilamide, anabolics.
• Mankhwala omwe amalimbikitsa kufunika kwa insulin: Kulera kwapakamwa, GCS, thiazide diuretics, mahomoni a chithokomiro, mankhwala osokoneza bongo a adrenomimetics, kukula kwa hormone, Danazole, mankhwala opangidwa ndi lithiamu, morphine, nikotini.
• Ngati pakufunika kuphatikiza insulin ndi beta-blockers, ziyenera kukumbukiridwa kuti mankhwala aposachedwa amatha kubisa mawonetsedwe a hypoglycemia.
• Zakumwa zokhala ndi zakumwa zoledzeretsa (zakumwa kapena mankhwala osokoneza bongo), Oktreotid, Lantreoyt akaphatikizidwa ndi insulini zitha kusintha mosayembekezereka: kulimbikitsa kapena kuchepetsa.
• Ngati munthu wodwala matenda ashuga, kuphatikiza insulin, atha kumwa mankhwala ena, ayenera kukambirana za momwe angamwere mankhwala ndi adokotala.

Bongo

Mwakutero, lingaliro la bongo pambuyo jakisoni wa insulin silinapangidwe. Kukhazikitsidwa kwa mlingo waukulu wa mankhwala aliwonse omwe ali ndi zomwe zingayambitse kukula kwa hypoglycemia. Kuchuluka kwa mphamvu pamilandu iyi sikungotengera kuchuluka kwa mankhwalawo, komanso momwe amagwiritsidwira ntchito kangapo, makamaka matenda a matenda ashuga, kupezeka kapena kusapezeka kwa zinthu zomwe zikukulitsa.

Zizindikiro za hypoglycemia zimayamba kukhala m'magawo, zikuwonjezereka chifukwa chosalephera kugwiritsira ntchito shuga.

Ngati matendawa adziwoneka bwino, kenako kuti athetse, wodwalayo akulimbikitsidwa kudya zakudya zam'madzi kapena shuga, kumwa tiyi wokoma kapena msuzi. Odwala ayenera kumakhala ndi chilichonse chokoma nawo kuti nthawi zonse pamakhala mwayi woti uzithandiza wokha munthawi yake.

Wovulala kwambiri, wodwala amasiya kuzindikira, ndipo akatswiri kapena anthu omwe akudziwa zofananazi amatha kumuthandiza.Kuti odwala matenda ashuga abwererenso, amamuboola pansi pakhungu kapena kubayikirana ndi glucagon mu minofu. Mowonjezereka, ngati njira zam'mbuyomu sizinapatse zotsatira zomwe akufuna, ndipo wodwalayo akupitilizika kukomoka, amapaka jekeseni ndi iv yokhala ndi dextrose solution. Wodwala matenda ashuga akadzazindikira, kuti apewe kugwa kwamwadzidzidzi m'magazi am'magazi, amaloledwa kudya maswiti kapena zakudya zopatsa mphamvu kwambiri.

Ndi okhawo omwe amapita ku endocrinologist omwe amatha kusankha ma analogu kapena m'malo mwa mankhwalawa, omwe amatha kuwerengera molondola mlingo wa insulin ndikusankha njira yoyenera ya jakisoni. Mankhwala omwe angathe kuyikidwa: Actrapid (MS, NM, NM-Penfill), Apidra, Biosulin R, Insuman Rapid GT, Rinsulin R, Rosinsulin R, Humalog, Humulin Regular.

Novo Nordisk PF do Brasil (Brazil)

Mtengo wapakati: (5 ma PC.) - 1799 rub.

Kukonzekera kwapafupipafupi kwa insulin kukonzekereratu kwa mtundu wa matenda ashuga 1, ndipo ngati kuli kotheka, kugwiritsa ntchito mtundu wa 2 wodwala, ngati kugwiritsa ntchito kwina kwa mankhwalawo sikunathandize kapena wodwalayo angatsutse pang'ono kapena ayi.

Penfill amapangidwa mu mawonekedwe a yankho la s / c ndi jekeseni wa iv. Amadzazana m'makalata agalasi. Mu gawo limodzi - 100 ZINSINSI za aspart. Mankhwalawa amagwiritsidwa ntchito mu machitidwe a Novo Nordisk.

Mtundu wa jakisoni ndi kuchuluka kwa njira zomwe Penfill amatsimikiza ndi katswiri.

• Kuchita mwachangu
• Chimodzi mwazinthu zabwino kwambiri zakutsuka.

• Siwothandiza aliyense
• Zimatenga nthawi yayitali mutatha kusintha insulin ina.

Kutengera mtundu wa shuga ndi njira yake, wodwalayo amapatsidwa mankhwala oyenera. Itha kukhala mapiritsi kapena insulini yamagulu osiyanasiyana. Gulu lomaliza la mankhwalawa limaphatikizapo jakisoni wa mtundu watsopano wa Novorapid.

Zambiri pazamankhwala

Insulin Novorapid ndi mankhwala am'badwo watsopano omwe amagwiritsidwa ntchito pochita zachipatala pochiza matenda ashuga. Chidacho chimakhala ndi vuto la hypoglycemic podzaza kuchepa kwa insulin ya anthu. Ili ndi zotsatira zazifupi.

Mankhwala amadziwika ndi kulolerana kwabwino komanso kuchitapo kanthu mwachangu. Pogwiritsa ntchito moyenera, hypoglycemia imachitika kangapo kuposa insulin ya munthu.

Imapezeka ngati jakisoni. Chomwe chimagwira ndi insulin. Aspart amafanana ndi mahomoni omwe amapangidwa ndi thupi la munthu. Amagwiritsidwa ntchito limodzi ndi jakisoni wokhala ndi nthawi yayitali.

Amapezeka m'mitundu iwiri: Novorapid Flexpen ndi Novorapid Penfil. Kuwona koyamba ndi cholembera, chachiwiri ndi makatoni. Aliyense wa iwo ali ndi mawonekedwe ofanana - insulin. Thupi limawonekera popanda turbidity komanso malingaliro a gulu lachitatu. Pakasungidwa nthawi yayitali, mpweya wabwino ungapangike.

Zizindikiro zochuluka

• kuzizira
• kutentha kukwera
• kugwedezeka kwamalire am'munsi,
• kukomoka
• tachycardia
• kuchuluka kwa mantha
• hypoglycemia.

Pakakhala chizindikiro chimodzi kapena zingapo, muyenera kufunsa dokotala kapena kuyitanira ambulansi. Kufikira dokotala popanda vuto kumatha kumabweretsa zotsatirapo zoyipa kwambiri.

Contraindication

• Hypoglycemia.
• Aliyense tsankho kwa zigawo zikuluzikulu za mankhwala.
• Nthawi ya pakati ndi kuyamwa.
• Ana osakwana zaka 6.

Zotsatira za pharmacological

Aspart imalumikizana ndi ma cell membrane receptors, kukonza ntchito yake. Adsorbed mwachangu kuposa insulin ya thupi, koma imakhala yochepa.

Nkhani za owerenga athu

Matenda a shuga kunyumba. Patha mwezi kuchokera pamene ndayiwala za kudumphira shuga komanso kumwa insulin. O, momwe ine ndimavutikira, kukomoka kosalekeza, kuyimba mwadzidzidzi. Kodi ndapita kangati kwa endocrinologists, koma amangonena chinthu chimodzi - "Tengani insulin."Ndipo tsopano masabata 5 apita, popeza kuchuluka kwa shuga m'magazi ndikwabwinobwino, osati jakisoni imodzi ya insulin ndipo chifukwa chonse cha nkhaniyi. Aliyense amene ali ndi matenda ashuga ayenera kuwerenga!

Mlingo ndi kasamalidwe koyenera

Mlingowo umaperekedwa ndi adokotala, aliyense payekha kwa wodwala aliyense. Amayambitsidwa pansi pa khungu m'malo ena:

• khomo lam'mimba lakunja
• phewa
• ntchafu yakunja.

Zizindikiro zochuluka

• kuzizira
• kutentha kukwera
• kugwedezeka kwamalire am'munsi,
• kukomoka
• tachycardia
• kuchuluka kwa mantha
• hypoglycemia.

Pakakhala chizindikiro chimodzi kapena zingapo, muyenera kufunsa dokotala kapena kuyitanira ambulansi. Kufikira dokotala popanda vuto kumatha kumabweretsa zotsatirapo zoyipa kwambiri.

Njira yosungira

Insulin imatha

Musanatenge Flekspen Insulin, werengani malangizowo.

Kupanga ndi mawonekedwe a kumasulidwa

Flekspen ndi insulin yomwe imakhala nthawi yayitali ngati ofanana ndi anthu. Izi zimapereka mwayi pakati pa mitundu ina ya mankhwalawa. Yotsatsa malonda posachedwa, kusintha ntchito yamaselo. Thupi limazolowera mankhwalawa, panthawi yogwiritsa ntchito "Flekspen" palibe kudalira.

Mankhwala awa ndi: amadzimadzi omveka opanda zodetsa. Mapangidwe a "Flexpen" akuphatikizira zotsatirazi:

Zizindikiro zogwiritsidwa ntchito

• Shuga mellitus, wamaudindo osiyanasiyana.
• Matenda ogwirizana ndi matenda ashuga.

Contraindication

Mankhwalawa ali ndi zotsutsana zina:

• mkaka ndi pakati,
• tsankho limodzi ndi zigawo za mankhwala,
• zaka mpaka 2.

Mlingo ndi njira yoyendetsera

Mlingowo umaperekedwa ndi adokotala, aliyense payekha kwa wodwala aliyense. Mukamawerenga kuchuluka kwake, zinthu zotsatirazi zimaganiziridwa:

• zaka odwala
• momwe wodwala alili, panthawi yopereka mankhwala,
• zosowa ndi moyo wa wodwala,
• kumwa mankhwala ena.

"Flekspen" imalowetsedwa pansi pa khungu ndi syringe yapadera ya insulin. Komanso, mankhwalawa amatha kuperekedwa kudzera m'mitsempha, koma jekeseni iyenera kuchitidwa ndi akatswiri odziwa ntchito zachipatala. Mulimonsemo, musamwe jakisoni minofu.

Kukhazikitsa kwa mankhwalawa kumachitika m'malo ena:

• gluteal patsekeke
• khomo lam'mimba lakunja
• ntchafu
• phewa.

Zotsatira zoyipa

Ngati mulingo wapambana, zizindikiro zotsatirazi zingachitike:

• kumverera kwa mantha
• tachycardia
• kugwedezeka miyendo,
• mutu
• kukomoka.

Chizindikiro ichi chimatha kuchitika, osangokhala ndi bongo wambiri, komanso kumwa mankhwala ena, chifukwa amatha kupititsa patsogolo insulin. Musanayambe kugwiritsa ntchito mankhwala atsopano, funsani katswiri.

Insulin ya Flekspen iyenera kusungidwa pa kutentha kwa madigiri 2-8. Kuwala kwamadzulo sikulimbikitsidwa. Taya zotengera zomwe zidagwiritsidwa ntchito ndi mankhwalawa, kugwiritsanso ntchito insulin yotseguka nkoletsedwa. Sungani tsiku lotha ntchito.

Mlingo ndi makonzedwe

Kuti mupeze chithandizo choyenera, mankhwalawa amaphatikizidwa ndi insulin yayitali. Pakukonzekera chithandizo, kuyang'anira shuga nthawi zonse kumachitika kuti glycemia ikhale m'manja mwake.

Novorapid ikhoza kugwiritsidwa ntchito zonse komanso kudzera m'mitsempha. Nthawi zambiri, odwala amapereka mankhwalawo m'njira yoyamba. Jakisoni wamkati amachitika kokha ndi wothandizira zaumoyo. Malo omwe analimbikitsidwa jekeseni ndi ntchafu, phewa, ndi kutsogolo kwa m'mimba.

Yang'anani! Kuti muchepetse zowopsa zomwe zimaphatikizidwa ndi lipodystrophy, tsamba la jakisoni liyenera kusinthidwa mkati mwa gawo limodzi.

Chidachi chimabayidwa pogwiritsa ntchito cholembera. Amapangidwa kuti azitha kutetezedwa mosavuta. Mankhwalawa amatha kugwiritsidwa ntchito ngati pakufunika kulowetsedwa. Panthawi yonseyi, zizindikiro zimayang'aniridwa. Pakakhala dongosolo kulephera, wodwalayo ayenera kukhala ndi insulin yopuma.Chitsogozo chatsatanetsatane chili mu malangizo ogwiritsira ntchito mankhwalawa.

Mankhwalawa amagwiritsidwa ntchito musanadye kapena pambuyo pake. Izi ndichifukwa cha kuthamanga kwa mankhwalawa. Mlingo wa Novorapid umatsimikiziridwa kwa wodwala aliyense payekhapayekha, poganizira zosowa zake zamankhwala komanso njira ya matendawa. Nthawi zambiri zotchulidwa tsiku lililonse Mlingo wapadera odwala ndi zikuonetsa

Pa nthawi yoyembekezera, kugwiritsa ntchito mankhwalawa kumaloledwa. Mukuyesa kuyipa kwa zinthu za mwana wosabadwa ndi mkazi sizinapezeke. Nthawi yonseyi, mlingo umasinthidwa. Ndi mkaka wa m`mawere, mulibe zoletsa.

Madzi amadzimadzi okalamba amachepa. Mukamazindikira mlingo, mphamvu za shuga zimawerengedwa.

Novorapid ikaphatikizidwa ndi mankhwala ena okhudzana ndi matenda ashuga, shuga amawunika nthawi zonse kuti apewe matenda a hypoglycemia. Pankhani yakuphwanya impso, pituitary gland, chiwindi, chithokomiro, pamafunika kusankha mosamala ndikusintha mlingo wa mankhwalawo.

Kudya kwambiri popanda chakudya kungayambitse vuto. Kugwiritsa ntchito molakwika kwa Novorapid, kungochoka mwadzidzidzi kungayambitse ketoacidosis kapena hyperglycemia. Posintha nthawi, wodwalayo angafunikire kusintha nthawi yomwe amwe mankhwalawo.

Musanafike paulendo wokonzekera, muyenera kufunsa dokotala. Mu matenda opatsirana, ophatikizana, kufunikira kwa wodwala kusintha kwamankhwala. Muzochitika izi, kusintha kwa mlingo kumachitika. Mukasamutsa kuchokera ku homoni ina, mosakayikira muyenera kusintha mtundu uliwonse wa mankhwala opatsirana.

Yang'anani! Mukasinthira ku Novorapid, zomwe zimatsogolera glycemia wowonjezereka mwina sizingatchulidwe ngati m'mbuyomu.

Zotsatira zoyipa ndi bongo

Chotsatira chosafunikira pambuyo pake ndi hypoglycemia. Kusintha kwakanthawi kochepa kumatha kuchitika m'dera la jakisoni - kupweteka, kufupika, kufinya pang'ono, kutupa, kutupa, kuyabwa.

Zochitika zotsatirazi zingachitike mu nthawi ya makonzedwe:

Ndi kukokomeza kwa mlingo, hypoglycemia yamatenda osiyanasiyana ikhoza kuchitika. Mankhwala osokoneza bongo pang'ono amatha kuthetsedwa popanda kutenga 25 g shuga. Ngakhale mlingo woyenera wa mankhwalawo nthawi zina umayambitsa hypoglycemia. Odwala ayenera kunyamula glucose nthawi zonse nawo.

Woopsa milandu, wodwalayo jekeseni ndi glucagon intramuscularly. Ngati thupi sililabadira mankhwalawo pakatha mphindi 10, ndiye kuti shuga amaperekedwa kudzera m'mitsempha. Kwa maola angapo, wodwalayo amayang'aniridwa kuti apewe kachiwiri. Ngati ndi kotheka, wodwalayo amapita kuchipatala.

Kuchita ndi mankhwala ena ndi analogi

Zotsatira za Novorapid zimatha kuchepa kapena kuwonjezeka motsogozedwa ndi mankhwala osiyanasiyana. Sitikulimbikitsidwa kusakaniza Aspart ndi mankhwala ena. Ngati sizotheka kuletsa mankhwala ena omwe si a shuga, muyenera kudziwitsa dokotala. Zikatero, mlingo umasinthidwa ndikuwunika kuwunika kwa zizindikiro za shuga kumachitika.

Kuwonongeka kwa insulin kumachitika chifukwa cha mankhwala okhala ndi sulfites ndi thiols. Mphamvu ya Novorapid imapangidwira ndi antidiabetesic agents, ketoconazole, kukonzekera komwe kumakhala ndi ethanol, mahomoni aamuna, fibrate, tetracyclines, ndi kukonzekera kwa lifiyamu. Walephera chifukwa - nikotini, antidepressants, kulera, adrenaline, glucocorticosteroids, heparin, glucagon, antipsychotic mankhwala, okodzetsa, Danazole.

Akaphatikizidwa ndi thiazolidinediones, kulephera kwamtima kumatha kukula. Mavuto amawonjezereka ngati pali chiyembekezo cha matendawa. Ndi mankhwala onse, wodwalayo amayang'aniridwa ndi achipatala. Mtima ukayamba kulipa, mankhwalawo amachotsedwa.

Mowa ungasinthe zotsatira za Novorapid - kuonjezera kapena kuchepetsa mphamvu yochepetsera shuga ya Aspart. Ndikofunikira kupewa mowa pochiritsa mahomoni.

Mankhwala ofanana omwe ali ndi chinthu chomwecho ndi mfundo zomwe mungagwiritse ntchito zimaphatikizapo Novomix Penfil.

Actrapid Hm, Vosulin-R, Insuvit N, Gensulin R, Insugen R, Insuman Rapid, Insular Aktiv, Rinsulin R, Humodar R, Farmasulin, Humulin amatchulidwa kukonzekera komwe kuli mtundu wina wa insulin.

Mankhwala omwe ali ndi insulin ya nyama ndi Monodar.

Yang'anani! Kusinthira ku mankhwala ena kumachitika kokha moyang'aniridwa ndi dokotala.

Phunziro la kanema wa syringe:

Maganizo a odwala

Kuchokera pa ndemanga za anthu odwala matenda ashuga omwe adagwiritsa ntchito insorapid insulin, titha kunena kuti mankhwalawa amadziwika bwino komanso amachepetsa shuga msanga, koma pamakhalanso mtengo wokwanira.

Mankhwalawa amachititsa moyo wanga kukhala wosavuta. Amachepetsa shuga mwachangu, samayambitsa mavuto, zokhwasula-khwasula ndizotheka ndi izo. Mtengo wokha ndiwokwera kuposa wa mankhwala ofananawo.

Antonina, wazaka 37, Ufa

Dotolo adamupangira chithandizo cha Novorapid limodzi ndi insulin "yayitali", yomwe imapangitsa shuga kukhala yabwinobwino kwa tsiku limodzi. Njira yovomerezeka imathandizira kudya panthawi yosakonzekera chakudya, imachepetsa shuga nditatha kudya. Novorapid ndi insulin wabwino wofatsa. Ma cholembera osavuta kwambiri, osafunikira syringes.

Tamara Semenovna, wazaka 56, Moscow

Mankhwala omwe mumalandira.

Mtengo wa Novorapid Flekspen (mayunitsi 100 / ml mu 3 ml) ndi pafupifupi ma ruble 2270.

Insulin Novorapid ndi mankhwala omwe ali ndi kufupikitsa kwa hypoglycemic. Ilinso ndiubwino kuposa njira zina zofananira. Chiwopsezo cha kukhala ndi hypoglycemia sichachilendo kusiyana ndi kugwiritsa ntchito mahomoni aumunthu. Cholembera cha syringe monga gawo lamankhwala chimapereka kugwiritsidwa ntchito kosavuta.

Zomwezi ndizovomerezeka mu 2011 ndipo zimaperekedwa pazofunsa zokha. Chonde funsani dokotala kuti asankhe mtundu wa chithandizo ndikutsimikiza kuti muwerenge kaye malangizo a mankhwalawo.

Dzina lachi Latin: NOVORAPID FlexPen

Wokhala ndi ziphaso zolembetsera: Wolembetsa NOVO NORDISK A / S (Denmark); wopangidwa ndi NOVO NORDISK A / S (Denmark) kapena Novo Nordisk Prodao Farmaceutica do Brasil Ltda (Brazil)

Chithunzi cha mankhwalawa "NOVORAPID Flexpen" ndichowongolera chokha. Wopangayo sanatiuze za kusintha pamapangidwe.

Ntchito malangizo NOVORAPID Flexpen (NOVORAPID FlexPen)

Fotokozani

Ngati muwerenga izi, mutha kuzindikira kuti inu kapena okondedwa anu mukudwala matenda ashuga.

Tinachita kafukufuku, tinaphunzira zambiri zamagulu ndipo makamaka ndinayang'ana njira ndi mankhwala ambiri a shuga. Chigamulochi ndi motere:

Ngati mankhwalawa onse akaperekedwa, zinali zotsatira zosakhalitsa, atangomaliza kudya, matendawa amakula kwambiri.

Mankhwala okhawo omwe adapereka chofunikira ndi kusiyana.

Pakadali pano, awa ndiye mankhwala okhawo omwe amachiritsiratu matenda ashuga. Makamaka machitidwe amphamvu a Kusiyanitsa adawonetsa koyambirira kwa matenda ashuga.

Tidafunsa Unduna wa Zaumoyo:

Ndipo kwa owerenga tsamba lathu lino mwayi
khalani ndi kusiyana ZAULERE!

Yang'anani! Milandu yogulitsa mankhwalawa yabodza Kusiyanako kwakhala komweko.
Mukayika lamulo pogwiritsa ntchito maulalo pamwambapa, mumatsimikiziridwa kuti mudzalandira malonda kuchokera kwa wopanga wamkulu. Kuphatikiza apo, mukamayitanitsa pa tsamba lovomerezeka, mumalandira chitsimikizo cha kubweza (kuphatikizapo ndalama zoyendera) ngati mankhwalawo alibe.

Masana, kuchuluka kwa insulini m'magazi sikokwanira. Pakudya, pachimake matendawa amatuluka. Kutsatira izi mu odwala matenda ashuga, insulin yochepa kwambiri, monga NovoRapid, imagwiritsidwa ntchito. Imaphatikizidwanso m'dongosolo loyambira la matenda osokoneza bongo kuti muchepetse shuga komanso kupewa kukula kwa zovuta za shuga.

Zotsatira zoyipa za NovoRapid

• Kuchokera ku endocrine system: zoyipa zomwe zimawoneka m'magulu omwe amagwiritsa ntchito NovoRapid ® FlexPen ® zimadalira kwenikweni pamankhwala ndipo zimachitika chifukwa cha insulin. Chochitika chovuta kwambiri chambiri ndi insulin ndi hypoglycemia. Hypoglycemia imayamba ngati mlingo waukulu wa insulin umayendetsedwa molingana ndi kufunika kwa insulin. Zizindikiro za hypoglycemia nthawi zambiri zimachitika mwadzidzidzi. Izi zitha kuphatikizira thukuta lozizira, khungu la khungu, kunjenjemera, kapena kunjenjemera, nkhawa, kutopa mosazolowereka kapena kufooka, kusokonezeka, chidwi, chizungulire, njala yayikulu, kusokonezeka kwakanthawi, mutu, nseru, tachycardia. Hypoglycemia yayikulu imatha kutha kwamtenda ndi / kapena kukhumudwa, kusokonezeka kwakanthawi kapena kosasintha kwa ubongo ndi imfa. Zomwe zimachitika chifukwa chogwiritsa ntchito NovoRapid® Flexpen ® zimafotokozedwera pansipa. Zotsatira zoyipa: pafupipafupi (> 1/1000, 1/10 000,

Malo osungira

• khalani pamalo owuma
• Sungani kuzizira (t 2 - 5)
• osayandikira ana
• sungani pamalo amdima

• 1 unit imafanana ndi 35 mcg wa mankhwala osokoneza bongo a insulin

NovoRapid amayamba kuchita zinthu mwachangu kwambiri kuposa yankho la insulin ya anthu, ndipo amatsitsa shuga m'magawo 4 oyambirira atatha kudya. Kutalika kwa kachitidwe pambuyo pa sc makonzedwe afupikitsa kuposa yankho la insulin yaumunthu. Zotsatira akufotokozera 10-20 mphindi pambuyo s / m'ma makonzedwe a khoma lachiberekero, ukufika kumtunda pambuyo maola 1-3 ndipo kumatha maola 3-5.

Mogwirizana ndi mankhwala NovoRapid Flexpen ndi mankhwala ena

Mao inhibitors, osasankha beta-blockers, ACE inhibitors, salicylates, anabolic steroids, oral hypoglycemic othandizira, octreotide, sulfanilamides, mowa ungathe kuchepetsa kufunika kwa insulin, mankhwala opatsirana pakamwa, corticosteroids, mahomoni a chithokomiro, ndipo muyenera kuwonjezera kufunika kwa insulinazole symatomolase

Chenjezo Pakatenga NovoRapid Flexpen

Mlingo wosakwanira kapena kusokonezeka kwa chithandizo, makamaka ndi matenda a shuga a insulin (mtundu 1), kumatha kubweretsa hyperglycemia ndi matenda ashuga a ketoacidosis.

Palibe zochitika zachipatala kwa ana ochepera zaka 6. NovoRapid iyenera kugwiritsidwa ntchito mwa ana m'malo momangokhala osachita insulini pokhapokha ngati kuyambitsa mwachangu kumatha kukhala ndi zotsatira zabwino - mwachitsanzo, ngati nkovuta kwa mwana kuti azitha kuyimitsidwa pakati pa jakisoni ndi zakudya.

Matenda obvuta, makamaka matenda, nthawi zambiri amachulukana, ndipo kuwonongeka kwa impso kapena chiwindi kumachepetsa kufunika kwa insulin. Kusamutsa wodwala kupita ku mtundu wina kapena mtundu wa insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Mukamagwiritsa ntchito NovoRapid Penfill, kuchuluka kwa jakisoni patsiku kapena kusintha kwa mankhwalawa kungafunike poyerekeza ndi omwe amagwiritsa ntchito insulin. Ngati pakufunika kusintha kwa mlingo, izi zitha kuchitika kale pakabayidwa koyamba kapena milungu ingapo kapena miyezi ingapo mutasinthira. Pambuyo kulipirira kagayidwe kazakudya kwa odwala, Zizindikiro zawo zakutsogolo kwa hypoglycemia zimatha kusintha, zomwe ayenera kudziwa. Kudumpha chakudya kapena masewera osakonzekera kungayambitse hypoglycemia. Gwiritsani ntchito mosamala makamaka mukamagwira ntchito yoyendetsa magalimoto ndi anthu omwe ntchito yawo imalumikizidwa ndi chidwi chochuluka, chifukwa hypoglycemia imatha kukhala, makamaka kwa odwala omwe ali ndi zofatsa kapena zosapezekapo, omwe ali patsogolo pa hypoglycemia kapena zochitika zake pafupipafupi.Zikatero, muyenera kuganizira mozama ngati kuli koyenera kuti wodwalayo ayendetse galimoto. Makatoni a Penfill ndi ogwiritsa ntchito nokha. Pambuyo jekeseni osachepera 6 s, singano imayenera kukhalabe pansi pa khungu pakumwa zonse.

Chenjezo pakugwiritsa ntchito

Matenda obvuta, makamaka matenda ndi matenda otupa, nthawi zambiri amawonjezera kufunikira kwa insulin.

Kusamutsa odwala kukhala mtundu watsopano kapena mtundu wa insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Ngati musintha ndende, mtundu, mtundu, magwiritsidwe antchito a insulin (nyama, anthu, ma insulin analogue) ndi / kapena njira yake yopangira, pangafunikire kusintha mlingo. Odwala omwe akutenga NovoRapid Flexpen angafunikire kuwonjezera kuchuluka kwa jakisoni kapena kusintha mlingo poyerekeza ndi insulin yokhazikika. Kufunika kosankha kwa mankhwalawa kumatha kuchitika pakukhazikitsa mankhwala atsopano, komanso pakubwera milungu ingapo kapena miyezi ingapo yogwiritsidwa ntchito.

Kudumpha zakudya kapena kuchita masewera olimbitsa thupi mosayembekezereka kungayambitse hypoglycemia. Kuchita masewera olimbitsa thupi mutangotha ​​kudya kumawonjezera chiopsezo cha hypoglycemia. NovoRapid Flexpen imakhala ndi metacresol, omwe nthawi zina amatha kuyambitsa mavuto.

Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere. Zomwe mungagwiritse ntchito mankhwalawa NovoRapid Flexpen panthawi yoyembekezera ndizochepa. Kafukufuku wazinyama adawonetsa kuti insulin, monga insulin ya munthu, ilibe mphamvu ya embryotoxic ndi teratogenic. Kuwongolera kowonjezereka kumalimbikitsidwa pochiza amayi apakati omwe ali ndi matenda ashuga panthawi yonse yovutikira, komanso panjira pakukayikira. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndikuwonjezeka kwambiri mu yachiwiri ndi yachitatu trimester. Palibe choletsa kuchiza matenda a shuga ndi NovoRapid Flexpen panthawi yoyamwitsa. Kuchiza pa nthawi ya pakati sikubweretsa chiopsezo kwa mwana. Komabe, munthawi imeneyi, zingakhale zofunika kuti mayi asinthe mlingo.

Kukopa pa luso loyendetsa magalimoto ndi zida. Kuyankha kwa wodwalayo komanso kuthekera kwake kochita chidwi kukhoza kukhala ndi vuto la hypoglycemia. Izi zitha kukhala zowopsa nthawi zomwe chidwi chimafunikira (mwachitsanzo, poyendetsa galimoto kapena pamakina ogwiritsa ntchito). Odwala ayenera kulangizidwa kuti azichita zinthu zoteteza hypoglycemia musanayendetse. Izi ndizofunikira kwambiri kwa odwala omwe afooka kapena kulibe zizindikiro - zotsogola za hypoglycemia kapena zochitika za hypoglycemia zimachitika pafupipafupi. Zikatero, kuyendetsa bwino kuyenera kuyesedwa.

Zochita Zamankhwala

Mankhwala omwe amatha kuchepetsa kufunika kwa insulin: othandizira pakamwa a hypoglycemic, octreotide, MAO inhibitors, osasankha β-adrenergic receptor blockers, ACE inhibitors, salicylates, mowa, anabolic steroids, sulfonamides.

Mankhwala omwe angapangitse kufunika kwa insulin: kulera kwapakamwa, thiazides, glucocorticosteroids, mahomoni a chithokomiro, sympathomimetics, danazol.

Ma blockers a ren-adrenergic amatha kubisa zizindikiro za hypoglycemia.

Mowa umatha kukulitsa mphamvu ya hypoglycemic ya insulin.

Kusagwirizana. Kuphatikiza kwa mankhwala ena ku insulin kungayambitse kuyambitsa kwake, mwachitsanzo, mankhwala okhala ndi thiols kapena sulfite.

Mlingo ndi makonzedwe a Novorapid

Chofunikira cha insulin nthawi zambiri chimakhala 0.5-1.0 U / kg / tsiku.Ngati pafupipafupi kugwiritsa ntchito molingana ndi kudya kwakuthupi ndi 50-70%, kufunika kwa insulin kumakhutitsidwa ndi NovoRapid Flexpen, ndipo ena onse ndi nthawi yayitali kapena otenga nthawi yayitali.

Njira yogwiritsira ntchito mankhwalawa NovoRapid Flexpen imadziwika ndi kuyambira mwachangu komanso kufupikitsa kwa nthawi poyerekeza ndi insulin yamunthu. Chifukwa cha kuyamba kwachangu, NovoRapid Flexpen nthawi zambiri imayenera kutumizidwa musanadye. Ngati ndi kotheka, mankhwalawa amatha kuperekedwa akangomaliza kudya.

NovoRapid imayendetsedwa pansi pa khungu la khoma lakunja kwam'mimba, ntchafu, mu minyewa yonyansa ya phewa kapena matako. Malowo a jakisoni amayenera kusinthidwa ngakhale mkati momwe momwemo. Ndi jakisoni wotsekemera wam'mimba khoma, mphamvu ya mankhwalawa imayamba Mphindi 10-20. Kuchuluka kwake kuli pakati pa maola 1-3 pambuyo pa jakisoni. Kutalika kwa kuchitapo kanthu ndi maola 3-5. Momwemo ndi ma insulin onse, makina amkati mwa khoma lamkati am'mimba amathandizira kuyamwa mwachangu kuposa momwe amapangidwira malo ena. Komabe, kuyambika kwakanthawi kothana ndi mankhwala a NovoRapid Flexpen poyerekeza ndi insulin ya anthu sungunuka mosasamala malo a jekeseni. Ngati ndi kotheka, NovoRapid Flexpen ikhoza kutumikiridwa iv, majakisoni awa amatha kuchitidwa motsogozedwa ndi dokotala. NovoRapid itha kugwiritsidwa ntchito popitiliza sc pothandizidwa ndi mapampu olowetsa oyenerera. Kupitiliza kwa sc kumachitika mu khoma lakunja kwam'mimba, tsamba la jakisoni liyenera kusinthidwa nthawi ndi nthawi. Mukamagwiritsira ntchito mapampu a kulowetsedwa, NovoRapid sayenera kusakanikirana ndi insulin ina iliyonse. Odwala omwe amagwiritsa ntchito mapampu olowetsedwa amayenera kuphunzitsidwa zambiri za kugwiritsa ntchito makina amenewa ndikugwiritsa ntchito makontena ndi machubu oyenera. Ma kulowetsedwa (machubu ndi ma cannulas) ayenera kusinthidwa malinga ndi zofunikira za malangizo omwe aphatikizidwa. Odwala omwe amagwiritsa ntchito NovoRapid pakukonzanso ayenera kukhala ndi insulini ngati atalephera. Kuchepa kwa chiwindi ndi impso kungathandize kuchepetsa wodwala kufunika kwa insulin. M'malo mosungunuka kwa insulin ya anthu, ana ayenera kupatsidwa mankhwala a NovoRapid FlexPen ngati kuli kofunika kupeza mwachangu insulin, mwachitsanzo, asanadye. NovoRapid Flexpen ndi cholembera chodzaza ndi sindanoFine® chokhazikitsidwa ndi singano za NovoFine®. Ma CD omwe amaphatikiza ndi singano za NovoFine® amalembedwa dzina la S. Flexpen limakupatsani mwayi kuti mulowe kuyambira 1 mpaka 60 magawo a mankhwalawo molondola 1 unit. Muyenera kutsatira malangizo a mankhwalawa pogwiritsa ntchito mankhwalawo. NovoRapid Flexpen idapangidwa kuti igwiritsidwe ntchito payekha, singagwiritsenso ntchito.

Malangizo Mankhwala NovoRapid Flexpen

NovoRapid lakonzedwa kuti jakisoni wa subcutaneous kapena jekeseni wosalekeza wogwiritsa ntchito mapampu kulowetsedwa. NovoRapid itha kuperekedwanso kudzera m'mitsempha moyang'aniridwa ndi dokotala.

Gwiritsani ntchito mapampu a kulowetsedwa

Pakumapaka kulowetsedwa, machubu amagwiritsidwa ntchito omwe mkati mwake amapangidwa ndi polyethylene kapena polyolefin. Insulini ina imayamba kumangika mkati mwa tangi ya kulowetsedwa.

Gwiritsani ntchito yolamula

Machitidwe a kulowetsedwa ndi NovoRapid 100 IU / ml pa insulini aspart ndende ya 0,05 mpaka 1.0 IU / ml mu kulowetsedwa njira yokhala ndi 0.9% sodium chloride, 5 kapena 10% dextrose ndi 40 mmol / l chloride. potaziyamu, ali mum'madzi a polypropylene kulowetsedwa, amakhala osungika kutentha kwa maola 24. Pa kulowetsedwa kwa insulin, ndikofunikira kuyang'anira kuchuluka kwa shuga m'magazi.