Insulin Glulizin, malangizo ogwiritsira ntchito kuchepetsa magazi

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Zinthu zina zambiri zosangalatsa

Maumwini onse ndi otetezedwa.

Kugwiritsa ntchito malonda pazinthu sikuloledwa.

Chidziwitsochi cholinga chake ndi akatswiri azachipatala.

Kuchita bwino ndi limagwirira ntchito

Ndi analogue ya insulin yamunthu, yomwe ili ndi zofanana. Nthawi yomweyo, wothandizirayo amachita zinthu mwachangu mthupi (mkati 10 mpaka 10 pambuyo pa kuperekera), koma amakhala ndi nthawi yayifupi.

Ntchito yayikulu ya mankhwalawa ndikuchepetsa kuchuluka kwa glucose, omwe amapezeka chifukwa cha kukondoweza kwa njira yotulutsira ndi zotumphukira zake.

Minofu ya mafupa ndi adipose minyewa imapangidwa bwino ndi shuga popanda kupanga nkhokwe yake m'chiwindi. Kuchita bwino kwa mankhwalawa sikudalira mtundu kapena mtundu wa wodwalayo.

Pharmacokinetic katundu

Kuyamwa kwa mankhwalawa m'thupi la munthu kumachitika mwachangu kwambiri (nthawi pafupifupi 2). Kafukufuku wotere adachitika kwa odwala omwe amadwala matenda amtundu wa 2 komanso matenda a shuga.

Ngati tilingalira makina obisika, nthawi yodwala pamavuto a mtundu wa 1 ndi mphindi 55, koma nthawi yomweyo, mahomoni abwinobwino amunthu amakhala akufalikira kwa pafupifupi mphindi 62.

Pambuyo pa kafukufuku wambiri, zidapezeka kuti mankhwalawo amagwira bwino ntchito kwambiri ngati atalowetsedwa subcutaneally khoma lamkati lakumbuyo, ndipo chotsatira chochepa chitha kupezeka m'dera la ntchafu.

Odwala omwe ali ndi vuto la impso amamva kugwiranso ntchito kofanana ndi mitundu ina ya odwala, koma ena a iwo amatha kuchepetsa kufunika kwa insulin. Kuchuluka kwa msambo komanso kutalika kwa mankhwalawa akaperekedwa kwa mwana kapena mwana azikhala wofanana ndi munthu wamkulu.

Zizindikiro ndi Kugwiritsa Ntchito

Mankhwalawa ali pafupifupi ofanana ndi anthu kupatula nthawi yowonekera, yomwe ndiyifupi. Ndikokwanira kupatsa wodwala jakisoni imodzi ya mankhwalawa, ndipo pakatha mphindi 15 amva bwino.

Njira zoyendetsera zitha kukhala zosiyanasiyana: mosazindikira munjira yina ya thupi komanso ndi pampu ya insulin. Kusankha komaliza kumachitika ndi kulowetsedwa (popanda kupuma) m'matumbo amafuta pansi pa khungu.

Njirayi iyenera kuchitika musanadye, kapena itatha, koma yomweyo. Kubaya jakisoni kumachitika bwino kwambiri pamimba, komanso amathanso kukhala phewa, ntchafu. Koma kulowetsedwa ndikololedwa kokha pamimba.

Ndi dokotala wokhawo amene angakupatseni mankhwala. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito ngati pakufunika kupatsa insulin kwa wodwala nthawi yayitali kapena yapakati.

Ndizovomerezeka kuphatikiza kukhazikitsidwa kwa mankhwala ndi mapiritsi (mankhwala a hypoglycemic). Mlingo komanso kusankha kwa mankhwalawo kumatsimikiziridwa ndi adotolo, popeza wodwalayo alibe ufulu wosankha yekha. Izi zili ndi zovuta zoyipa.

Mwa malangizo apadera omwe mungagwiritsire ntchito, mutha kupezanso chidziwitso cha malo omwe mankhwalawo amakuperekera. Chifukwa chake, ndikofunikira kupewa mitsempha yamagazi.

Kuphatikiza apo, ndizoletsedwa kutikita minofu komwe adapangira jakisoni.

Zotheka kukhala ndi mavuto

Ngati Insulin Glulizin yasankhidwa, malangizo omwe angagwiritsidwe ntchito ayenera kuchenjeza ogwiritsa ntchito za zotsatira zoyipa zingapo. Ngati munthu wakupatsani kuchuluka kwa mankhwalawa ochulukirapo, koma osafuna, wodwalayo atha kukhala ndi hypoglycemia. Izi ndi zotsatira zoyipa kwambiri chifukwa chogwiritsa ntchito mankhwalawa.

Pamaso pazotsatira zoyipa zoterezi ndikulowetsedwa kwa mankhwalawa, wodwalayo nthawi zambiri amakhala ndi zizindikiro za matendawo nthawi yomweyo. Amaponyedwa thukuta lozizira, munthu amamva kutopa, kugona komanso kusokonezeka. Nthawi yomweyo amakhala ndi miyendo komanso chikondwerero champhamvu.

Zizindikiro zowonjezera: nseru, palpitations, ndi kutupa kwa mitsempha. Zizindikiro za pathology iyi zimakula, ngati sangayimitsidwe, munthu akhoza kulephera kudziwa. Wodwala amapezeka kuti wakomoka, kugwira ntchito kwa ubongo kumadodometsa, ndipo vuto lalikulu kwambiri, limamupangitsa kuti afe.

Pafupipafupi, odwala amawona kusokonezeka kwapadera mu ntchito ya thupi lawo. Mwachitsanzo, nthawi zina wodwala amatha kumva kuwawa, ming'oma, kapena khungu. Zizindikiro zimatha kukhala limodzi ndi kumva kukomoka pachifuwa kapena kukomoka. Ngati zotsatirapo zoyipa zimayamba kugwirira ntchito kwambiri, chifukwa chake pamakhala kugundana, mantha a anaphylactic, izi zimatha kupha.

Nthawi zina zochita za hypersensitivity zimadziwika pakhungu pamalo opaka jekeseni. Itha kufotokozedwa ngati dera lokongola lomwe limayamwa. Popita nthawi, vutoli limafanana lokha, ndipo njira zingapo zikadzatheratu. Odwala ena amatha kukhala ndi lipodystrophy.

Gwiritsani ntchito pobereka komanso podyetsa ana

Ngati Glulisin adalembedwa kwa mkazi nthawi yosangalala koma yovutayi, malangizowo akufotokozera zomwe zimagwiritsidwa ntchito pa mankhwalawa ngati chinthu chosiyana. Malowa sanaphunziridwe bwino, chifukwa chake, palibe chidziwitso chokwanira.

Mankhwalawa anayesedwa pazinyama. Phunziroli silinawonetse kusiyana pakukhazikitsidwa kwa chida ichi ndi kusiyanasiyana kwaumunthu pakubala. Pambuyo pa kuyambitsa, palibe kusintha komwe kunawonedwa pakukula kwa mwana wosabadwayo panthawi ya kubereka komanso pambuyo pake.

Koma nthawi yomweyo, odwala otere ayenera kukhala osamala popereka mankhwalawo. Njirayi iyenera kuchitika moyang'aniridwa ndi shuga. Pankhani ya matenda ashuga, mkazi ayenera kuyang'anira kuchuluka kwa kagayidwe kake.

Nthawi zambiri, madokotala amachenjeza odwala kuti asinthe ma Mlingo wambiri pokhudzana ndi msambo. Chifukwa chake, amachepetsa mlingo mu trimester yoyamba, ndikuchulukira panthawi yazotsatira ziwiri zotsatila. Mayiyo akadzabereka, adzapeza kuchepa kwa zofunika za insulin.

Thupi silimalowa mkaka wa m'mawere ndipo silimayamwa mkaka wa m'mawere. Koma dotolo yemwe akupezekapo amatha kusintha mankhwalawa panthawiyi ndikupereka zakudya zapadera kwa mzimayi.

Kuchita ndi mankhwala ena

Insulin Glulisin akaphatikizidwa ndi guanethidine angayambitse kukula kwa hypoglycemia, zomwe sizidzawala kwambiri.

Magulu otsatirawa a mankhwala amatha kukhala othandizira pakukula kwa zoyipa:

• Ma Disopyramides,
• Mao kapena PAF zoletsa,
• Sulfonamides,
• Fibates
• Salicylates,
• Propoxyphene.

Kutsika kwa zizindikiro za hypoglycemic kumawonedwa ndi kuphatikiza kwa mankhwala ndi njira zotere:

• Zodzikongoletsera
• Danazole
• Mapuloteni oletsa
• Diazoxide
• Mankhwala a antipsychotic
• Epinephrine et al.

Magulu otsatirawa a mankhwala amachepetsa mphamvu za insulin:

Simungathe kuletsa, mwachangu kapena kuwonjezera kuchuluka kwa mankhwalawo, komanso kuphatikiza ndi mankhwala ena. Kusintha kwa mtundu wina wa insulin kumachitika kokha ndi adokotala, ndipo izi zimachitika moyang'aniridwa ndi achipatala.

Pakadali pano, kusintha kwapakanthawi kwa mlingo kungakhale kofunikira. Ngati simutsatira malangizowa kapena kulowa mankhwala molakwika, mutha kuyambitsa chidwi cha hypoglycemia, komanso chinthu china choopsa.

Kuphatikiza apo, adotolo amatha kusintha mlingo ngati wodwalayo asintha mu zakudya, komanso zochitika zolimbitsa thupi. Mukangodya, wodwalayo amaletsedwa kuyenda mwachangu, chifukwa izi zimapangitsa kuyamba kwa hypoglycemia.

Kupanga ndi mafomu omasulira

1 ml muli magawo 100 a yogwira ntchito. Zothandiza: hydrochloric acid, sodium chloride, madzi oyera a jakisoni, okhazikika.

Glulisin insulin imapezeka m'matumba apadera ogwiritsa ntchito jakisoni wa subcutaneous, womwe umayikidwa mumbale 3 ml. Zina zomwe zaphatikizidwa ndi zolembera zokhazikitsidwa ndi syringe, zomwe ndi 5 phukusi.

Kuchiritsa katundu

Mtengo wapakati wa mankhwala ku Russia ndi ma ruble 1,500 pakiti iliyonse.

Glulin insulin ili ndi katundu wa hypoglycemic. Pambuyo pakugwiritsa ntchito, kutsika kwamphamvu kwa shuga m'magazi kumachitika, chifukwa mankhwalawa ndi osakhalitsa pakapita nthawi. Mankhwalawa amayamba kugwira ntchito pafupifupi mphindi 15, ndipo nthawi yovutayo ndi maola ochepa. Mankhwalawa amathandizira kudzikundikira kwa minofu ndi minyewa ya adipose, amalimbikitsa kuyendetsa mwachangu kwa glycogen ku chiwindi.

Njira yogwiritsira ntchito

Muyenera kupaka jakisoni mankhwalawa mukatha kudya kapena mphindi 10-15 musanadye. Ndikofunika kuphatikiza mtundu wapafupi wa mankhwalawo ndi sing'anga kapena nthawi yayitali. Mankhwalawa amayenera kudulidwa m'malo osiyanasiyana a thupi kuti lipodystrophy isachitike. Malo otsogolera singano ndi oyenera bwino: m'mimba, m'chiuno, mikono, mapewa. Ngati mukugwera m'mimba, ndiye kuti mankhwalawa amamwa kwambiri mwachangu.

Pa nthawi yoyembekezera komanso yoyamwitsa

Amayi oyembekezera komanso oyembekezera amayenera kugwiritsa ntchito mankhwalawa mosamala kwambiri, popeza pali kusintha kwamalingaliro ndi kusintha koyenera kuyenera kuyang'aniridwa ndi katswiri.

Contraindication ndi Kusamala

Musagwiritse ntchito insulini glulisin ngati simungalole kapena kuponderezana.

Kuchita mankhwala osokoneza bongo

Chepetsani zochitika za mankhwalawa: anabolic steroids, njira zakulera za pakamwa, estrogen ndi progesterone, mowa, danazol, corticosteroids ndi mahomoni a chithokomiro.

Amathandizanso kugwira ntchito kwa mankhwalawa: fluxen, pentoxifylline, sulfonamides, salicylates, fibrate, mankhwala ochepetsa shuga.

Zotsatira zoyipa ndi bongo

Mseru wothekera, chisokonezo, njala yayikulu, kuchepa kwa magwiridwe, kukokana, kugunda kwamtima.

Ngati pali zizindikiro za hypoglycemia, ndiye kutengera mtundu wake, muyenera kudyetsa munthu mokoma kapena kuyitanira ambulansi.

Lilly France, France

Mtengo wapakati ku Russia - ma ruble 1600 phukusi lililonse.

Fomu - Lyspro insulin, amatanthauza ma mahomoni a ultrashort.

Ubwino:

Chuma:

• Zodula
• Chiwopsezo chachikulu cha hypoglycemia.

Novo Nordisk, Denmark

Mtengo wapakati - ma ruble 400 phukusi lililonse.

Insulin yachilendo yachilendo pamtengo wabwino.

Ubwino:

Chuma:

• Osati mwachangu kwambiri
• Mwina sizingafanane.