Metformin-Teva: malangizo a mankhwala

Metformin ndi mankhwala omwe amapangidwa ndi opanga mawonekedwe a mapiritsi okhala ndi mamiliyoni angapo a milligram of the main yogwira.

Mu msika wogulitsa, mankhwala amaperekedwa omwe ali ndi yogwira pawiri ya 500, 850 mg ndi 1000 mg.

Mapiritsi onse okhala ndi 500, 850 mg ndi 1000 mg amasiyana pakati pawo osati kuchuluka kogwira pophika.

Mtundu uliwonse wa piritsi umayenera kusiyana pakati pawo mwa kujambulidwa pamankhwala.

Kapangidwe ka mankhwala ndi mafotokozedwe ake

Mapiritsi okhala ndi kuchuluka kwa gawo lalikulu la 500 mg ali ndi mtundu woyera kapena pafupifupi. Kunja kwa mankhwalawo kumakutidwa ndi membrane wa filimu, yemwe amalemba "93" mbali imodzi ya mankhwalawo ndi "48" mbali inayo.

Mapiritsi a 850 mg ndi chowulungika komanso filimu. Pamaso pa chigobacho, papangidwe “93” ndi “49”.

Mankhwalawa, okhala ndi kuchuluka kwa 1000 mg, amakhala ozungulira bwino komanso wokutidwa ndi filimu yamafuta omwe amagwiritsa ntchito ziwopsezo mbali zonse ziwiri. Kuphatikiza apo, zinthu zotsatirazi zalembedwa pa chipolopolo: "9" kumanzere kwa zoopsa ndi "3" kumanja kwa zoopsa mbali imodzi ndi "72" kumanzere kwa zoopsa ndi "14" kumanja kwa zoopsa mbali inayo.

Chofunikira chachikulu cha mankhwalawa ndi metformin hydrochloride.

Kuphatikiza pazomwe zimapangidwira, mapangidwe a mankhwalawa amaphatikizapo othandizira, monga:

• povidone K-30,
• povidone K-90,
• silica colloidal
• magnesium wakuba,
• hypopellose,
• titanium dioxide
• macrogol.

Mankhwalawa adapangira kuti azigwiritsidwa ntchito pakamwa ndipo ali m'gulu la Biguanides.

Dziko lomwe adachokera ndi Israeli.

Pharmacodynamics ndi pharmacokinetics a mankhwalawa

Kugwiritsa ntchito Metformin kumathandizira kuchepetsa kuchuluka kwa shuga m'magazi a shuga amtundu wachiwiri. Kuchepa kwa ndende kumachitika chifukwa cha kuletsa kwa ma bioprocesses a gluconeogeneis m'maselo a chiwindi ndi mphamvu ya bioprocesses ya kugwiritsidwa ntchito kwake m'maselo a insulin. Izi zimakhala ndi minofu yolimba ndi adipose.

Mankhwala samakhudza ma bioprocesses omwe amawongolera kapangidwe ka insulin m'maselo a pancreatic beta. Kugwiritsa ntchito mankhwalawa sikuti kumapangitsa kuti mukhale ndi hypoglycemic. Kugwiritsa ntchito mankhwalawa kumakhudza bioprocesses yomwe imachitika pa lipid metabolism, pochepetsa zomwe zili triglycerides, cholesterol ndi lipoproteins yotsika mu seramu yamagazi.

Metformin imakhala ndi zolimbikitsa pazomwe zimachitika mu intracellular glycogeneis. Zokhudza intracellular glycogeneis ndi activation ya glycogenitase.

Mankhwala atalowa m'thupi, Metformin imangotsala pang'ono kulowa m'magazi kuchokera m'mimba. The bioavailability wa mankhwalawa kuchokera 50 mpaka 60 peresenti.

Pazipita ndende ya yogwira amapezeka mu madzi am`magazi 2,5 pambuyo kumwa mankhwala. Patatha maola 7 mutatha kumwa mankhwalawa, kuyamwa kwa mankhwala opakidwa pang'onopang'ono kuchokera m'magazi kumatha, ndipo mankhwala omwe amapezeka m'madzi amayamba kuchepa. Mukamamwa mankhwalawo ndi chakudya, mayamwidwe amachepetsa.

Pambuyo polowera mu plasma, metformin sikugwirizana ndi mapuloteni omaliza. Ndipo amagawidwa mwachangu mthupi lonse.

Kuchoka kwa mankhwalawa kumachitika pogwiritsa ntchito impso. Metformin imachotsedwa osasinthika kuchoka m'thupi. Hafu ya moyo wa mankhwalawa ndi maola 6.5.

Zizindikiro ndi contraindication ntchito mankhwala

Chizindikiro chogwiritsira ntchito mankhwalawa Metformin mv ndi kukhalapo kwa matenda ashuga mwa munthu, omwe sangathe kulipidwa pogwiritsa ntchito zakudya komanso zolimbitsa thupi.

Metformin mv Teva ikhoza kugwiritsidwa ntchito pokhazikitsa monotherapy, komanso ngati imodzi mwazinthu zomwe zimapangitsa kuti pakhale zovuta kuchita.

Pochita mankhwala ovuta, ma hypoglycemic othandizira pakamwa kapena insulin angagwiritsidwe ntchito.

Milandu ikuluikulu yomwe imamwa mankhwalawa ndi iyi:

1. Kukhalapo kwa hypersensitivity ku gawo lalikulu la mankhwala kapena pazinthu zothandizira.
2. Wodwala ali ndi matenda a shuga a ketoacidosis, matenda a shuga kapena chifuwa.
3. Kuwonongeka kwa impso kapena kulephera kwa aimpso.
4. Kukula kwa pachimake zinthu zomwe zimawoneka ngati kuwonongeka kwa impso ndizotheka. Zinthu ngati izi zimaphatikizira kuchepa madzi m'thupi komanso hypoxia.
5. Kupezeka mu thupi lotchulidwa mawonekedwe a matenda omwe angayambitse kuwoneka kwa minofu hypoxia.
6. Kuchita maopareshoni ambiri.
7. Wodwala amakhala ndi vuto la chiwindi.
8. Kupezeka kwa uchidakwa wodwala mwa wodwala.
9. Mkhalidwe lactic acidosis.
10. Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa maola 48 asanafike ndi maola 48 mayeso atachitika pogwiritsa ntchito ayodini.
11. Sibwino kugwiritsa ntchito mankhwalawa maola 48 asanafike ndi maola 48 atachitidwa opaleshoni, yomwe imayendera limodzi ndi kugwiritsa ntchito mankhwala opaleshoni wamba.

Kuphatikiza pa zochitika izi, mankhwalawa sagwiritsidwa ntchito pokhapokha ngati chakudya chamafuta ochepa komanso ngati wodwala akudwala matenda ashuga osakwana zaka 18.

Mankhwala ndi oletsedwa kugwiritsidwa ntchito pakubala mwana kapena poyamwitsa.

Mukakonzekera kukhala ndi pakati, Metformin MV Teva imalowedwa m'malo ndi insulin komanso insulin yothandizira matenda a shuga mellitus amachitika. Munthawi ya bere ndi nthawi yoyamwitsa, wodwalayo amayang'aniridwa ndi achipatala.

Ngati kuli kofunikira kumwa mankhwalawa nthawi yoyamwitsa, ndikofunikira kusiya kuyamwitsa mwana mkaka wa m'mawere.

Malangizo ogwiritsira ntchito mankhwalawa

Pakukhazikitsa mankhwala a Metformin Teva, malangizowo ndi okwanira ndipo amafotokoza mwatsatanetsatane malamulo ovomerezeka ndi mlingo, womwe umalimbikitsidwa kuti uvomereze.

Mankhwalawa amayenera kumwedwa pakudya kapena atangomaliza kudya.

Mlingo woyambirira wa mankhwalawa amatha, kutengera kufunika kwake, amasiyana 500 mpaka 1000 mamililita kamodzi patsiku. Ndi bwino kumwa mankhwalawa madzulo. Pakakhala zotsatirapo zoyenera za kumwa mankhwalawo patatha masiku 7-15, mlingo wa mankhwalawa, ngati pakufunika, utha kuwonjezeredwa mpaka 500-1000 milligrams kawiri pa tsiku. Ndi makonzedwe awiri a mankhwalawa, mankhwalawa amayenera kumwedwa m'mawa ndi madzulo.

Ngati ndi kotheka, mtsogolo. Kutengera kuchuluka kwa shuga m'thupi la wodwalayo, mlingo wa mankhwalawo ukhoza kuwonjezereka.

Mukamagwiritsa ntchito kukonzanso mlingo wa Metformin MV Teva, tikulimbikitsidwa kuti mutenge 1500 mpaka 2000 mg / tsiku. Kuti mankhwala a Metformin MV Teva atengedwe kuti asakwiyitse wodwala kuti asatengere m'matumbo am'mimba, mulingo wa tsiku ndi tsiku umalimbikitsidwa kuti mugawidwe pakati Mlingo 2 kapena 3.

Mlingo wovomerezeka wa Metformin MV Teva ndi 3000 mg patsiku. Mlingo wa tsiku ndi tsiku uyenera kugawidwa pawiri.

Kukhazikitsa kuwonjezeka kwapang'onopang'ono kwa mlingo wa tsiku ndi tsiku kumathandizira kusintha kwamtundu wa mankhwalawa.

Mukasinthana ndi mankhwala ena omwe ali ndi vuto la hypoglycemic kupita ku Metformin MV Teva, muyenera kusiya kumwa mankhwalawa kenako ndikuyamba Metformin.

Mankhwala a Metformin MV Teva angagwiritsidwe ntchito nthawi imodzi ndi insulin ngati gawo limodzi la mankhwala othandizira. Mukamagwiritsa ntchito mankhwalawa limodzi, tikulimbikitsidwa kugwiritsa ntchito insulin kwa nthawi yayitali. Kugwiritsa ntchito ma insulin kwa nthawi yayitali kuphatikiza ndi Metformin kumakupatsani mwayi wokwanira m'thupi la munthu.

Musanagwiritse ntchito mankhwalawa, kuyezetsa magazi pazomwe zili ndi shuga kumafunikira, mlingo wa mankhwalawa umasankhidwa palokha.

Pogwiritsa ntchito mankhwalawa mankhwalawa odwala okalamba, mlingo wa mankhwalawa patsiku sayenera kupitirira 1000 mg patsiku.

Zotsatira zoyipa ndi zovuta za bongo

Mukamagwiritsa ntchito mankhwalawa, mavuto ena amatha kuwonekera m'thupi la wodwalayo.

Kutengera pafupipafupi kwa zomwe zimachitika, zotsatira zoyipa zimagawika m'magulu atatu: nthawi zambiri - kuchuluka kwake kumapitilira 10% kapena kuposerapo - kawirikawiri - izi zimachokera ku 1 mpaka 10%, osati kawirikawiri - zochitika zazotsatira zimachokera ku 0.1 mpaka 1%, kawirikawiri - zovuta zoyambira zimachokera ku 0,01 mpaka 0,1% ndipo kawirikawiri zomwe zimachitika ndizotsatira zosachepera 0.01%.

Zotsatira zoyipa mukamamwa mankhwalawa zimatha kuchitika pafupifupi mthupi lililonse.

Nthawi zambiri, maonekedwe a kuphwanya lamulo chifukwa chomwa mankhwalawa akuti:

• Kuchokera kumanjenje
• m'mimba,
• mu mawonekedwe a thupi lawo siligwirizana,
• kuphwanya kagayidwe kachakudya njira.

Kuchokera kumbali ya dongosolo lamanjenje lamkati, zotsatira zoyipa zimawonekera pakukhumudwa.

Mukamamwa mankhwalawo m'matumbo am'mimba, zovuta ndi zovuta zotsatirazi zitha kuchitika:

1. Kuchepetsa mseru
2. Zilango zakusanza.
3. Ululu pamimba.
4. Kuchepetsa chidwi.
5. Kuphwanya chiwindi.

Thupi lawo siligwirizana nthawi zambiri limakhala mu erythema, kuyabwa pakhungu ndi zotupa pakhungu.

Dokotala akuyenera kufotokozera odwala matenda ashuga momwe amamwe Metformin kuti apewe zoyipa. Osowa kwambiri, odwala omwe amatha kugwiritsa ntchito mankhwalawa kwa nthawi yayitali amatha kukhala ndi B12 hypovitaminosis.

Pogwiritsa ntchito Metformin pa mlingo wa 850 mg, kukula kwa zizindikiro za hypoglycemic sikuwonetsedwa mwa odwala, koma nthawi zina lactic acidosis imatha kuchitika. Ndi kukula kwa chizindikiro chosavomerezeka ichi, munthu amakhala ndi zizindikiro monga:

• kumva mseru
• kufuna kusanza
• kutsegula m'mimba
• dontho kutentha kwa thupi
• kupweteka pamimba,
• kupweteka kwa minofu
• kupumira msanga
• chizungulire komanso chikumbumtima.

Kuti muchotse bongo mopitirira muyeso, muyenera kusiya kumwa mankhwalawo ndikugwirira ntchito yodziwitsa.

Mndandanda wa mankhwalawa, mtengo wake ndi kuwunika kwake

Mapiritsi ogulitsa m'mafakitale amagulitsidwa pamakatoni, ndipo chilichonse chimakhala ndi matuza angapo momwe mapiritsi amwe amadzaza. Chotupa chilichonse chimanyamula mapiritsi 10. Katemera wa makatoni, kutengera kunyamula, atha kukhala ndi matuza atatu mpaka 6.

Sungani mankhwalawo pamtunda osapitirira 25 digiri pamalo amdima. Alumali moyo wa mankhwala ndi zaka 3.

Sizingatheke kugula mankhwalawo pawokha m'masitolo, chifukwa kutulutsidwa kwa mankhwala kumachitika pokhapokha ngati mumalandira mankhwala.

Ndemanga za odwala omwe adagwiritsa ntchito mankhwalawa mankhwalawa zimawonetsa kugwira ntchito kwake bwino. Odwala ambiri amasiyira ndemanga zabwino za mankhwalawo. Kuwunikira kuwunika koyipa nthawi zambiri kumayenderana ndi kuwoneka kwa zoyipa zomwe zimachitika ndikuphwanya malamulo ovomerezeka komanso mankhwala osokoneza bongo.

Pali mitundu yambiri ya fanizo la mankhwalawa. Zodziwika kwambiri ndi:

1. Bagomet.
2. Glycon.
3. Glyminfor.
4. Glformin.
5. Glucophage.
6. Langerine.
7. Metospanin.
8. Metfogamma 1000.
9. Metfogamm 500.

Taccena Metformin 850 ml imadalira malo ogulitsa mankhwala ndi dera lomwe likugulitsidwa ku Russian Federation. Mtengo wapakati wa mankhwalawo mumasamba ocheperako umachokera ku 113 mpaka 256 rubles.

Kanemayo munkhaniyi akukamba za zochita za Metformin.

Mapiritsi a Metformin-Teva

Malinga ndi gulu la zamankhwala, Metformin-Teva amatanthauza mankhwala am'mlomo a hypoglycemic. Izi zikutanthauza kuti bwino amachepetsa shuga m'magazi kukhala achizolowezi, kuonetsetsa kugwira ntchito koyenera kwa kapamba. Zomwe zimapangidwira zimapangidwa ndi metformin ya dzina lomweli monga mankhwala, omwe ali m'gulu la Biguanide.

Kupanga ndi mawonekedwe a kumasulidwa

Mitundu itatu yamankhwala yotulutsira mankhwala imakhala yosiyanitsidwa, yosiyana ndi ndende ya yogwira. Kupanga kwawo ndi kufotokozera kwawonetsedwa patebulo:

Metformin 500 mg

Metformin 850 mg

Metformin 1000 mg

Mapiritsi oyera okhala ndi mafilimu okhala ndi ngozi

The ndende ya yogwira thunthu, mg pa pc.

Povidone, macrogol, magnesium stearate, titanium dioxide, colloidal silicon dioxide, hypromellose (Opadry yoyera)

Matumba a ma PC 10, matuza atatu kapena 6 mum pack

Pharmacodynamics ndi pharmacokinetics

Chomwe chimagwiritsidwa ntchito popanga ndi cha gulu la Biguanides. Kulowa wodwala matenda ashuga, amachepetsa kuchuluka kwa shuga m'magazi, ndikulepheretsa gluconeogeneis m'chiwindi. Thupi limachepetsa kuyamwa kwa shuga ndimakoma am'mimba, ndikuwonjezera chidwi cha insulin. Zochita zamankhwala zimaperekedwa kwa minofu yolumikizidwa. Mankhwalawa samalimbikitsa insulin secretion, sayambitsa ma hypoglycemic, koma amatenga lipid metabolism, amachepetsa cholesterol ndende mu seramu.

Mankhwala amatha kuyambitsa intracellular glycogeneis ndi activation ya glycogen synthase enzyme. Thupi limatengeka kwathunthu kuchokera m'mimba, lili ndi 55% bioavailability, limafikira pazowonjezera ziwiri pambuyo pa maola a 2,5. Pakatha maola asanu ndi awiri, metformin imasiya kuyamwa. Vutoli limalowa m'magazi ofiira, limadziunjikira m'chiwindi, kumiseche, komanso impso. Metformin amuchotseredwa ndi impso mu maola 13mu kulephera kwa aimpso, nthawi ino imachuluka. Chidacho chitha kudziunjikira.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo ogwiritsidwira ntchito omwe atsekedwa mu paketi iliyonse ndi mankhwalawo, iye Amagwiritsidwa ntchito pokhapokha ngati pali mtundu wa shuga wachiwiri mwa odwala akuluakulu. Madokotala nthawi zambiri amapereka mankhwala kwa odwala omwe ali ndi kunenepa kwambiri omwe sanathandizidwe ndi zakudya kapena zolimbitsa thupi. Metformin itha kugwiritsidwa ntchito mu monotherapy kapena kuphatikiza mankhwalawa.

Malangizo ogwiritsira ntchito Metformin-Teva

Mankhwalawa amatengedwa pakamwa pakudya kapena pambuyo chakudya. Mu monotherapy, muyeso woyamba ndi 500-100 mg kamodzi. Pambuyo pa masiku 7-15, pakalibe zinthu zoyipa kuchokera m'mimba, 500-1000 mg imayikidwa kawiri patsiku m'mawa komanso madzulo. Ngati izi sizikuthandizani, mlingowo ungangowonjezereka. Mlingo wokonza umawonedwa kuti ndi 1500-2000 mg patsiku mu Mlingo wa 2-3.

Mlingo woyenera wa tsiku lililonse wa mankhwalawa ndi 3000 mg mu atatu. Madokotala nthawi zonse amapereka kuchuluka pang'onopang'ono kwa mlingo, womwe umathandizira kukometsa kwa m'mimba. Mukamatenga 2000-3000 mg patsiku, mutha kusamutsa wodwala ku mlingo wa 1000 mg. Mukasinthira ku chithandizo chamankhwala ena ofanana, muyenera kusiya kutenga woyamba ndikusinthira ku Metformin-Teva pa mlingo woyamba.

Metformin-Teva wokhala ndi Insulin

Ndi kuphatikiza kwa mankhwala ndi insulin, cholinga cha mankhwalawa ndikwaniritsa bwino glycemic control. Mlingo woyamba wa Metformin-Teva umakhala 500 kapena 850 mg 2-3 kawiri pa tsiku, ndipo mlingo wa insulin umasankhidwa kutengera mayeso a shuga wamagazi. Pambuyo masiku 10-15, mlingo umatha kusintha. Pazipita tsiku mlingo 2 g mu 2-3 waukulu. Mwa odwala okalamba, phindu limatsitsidwa mpaka 1000 mg.

Malangizo apadera

Musanagwiritse ntchito mankhwalawa, muyenera kuphunzira gawo la malangizo apadera pamalangizo. Pali mafotokozedwe omwe amathandiza kumwa mankhwala:

• munthawi ya chithandizo, mankhwalawa amayenera kuchitika kawirikawiri pamimba yopanda kanthu ndikatha kudya,
• musanachite kafukufuku wa X-ray pogwiritsa ntchito zinthu za radiopaque pakukonzekera kwa mtsempha wamagazi kapena urology, mankhwalawa satengedwa kwa maola 48, kuphatikiza apo samamwa kwambiri pambuyo pa njirayo
• momwemonso iyenera kusiyidwa musanayambe kapena pambuyo poti muchite opaleshoni yothandizidwa ndi opaleshoni wamba,
• Matenda a ziwalo zoberekera atapezeka, funsani dokotala.
• Metformin-Teva sangaphatikizidwe ndi mowa chifukwa chowopsa cha hypoglycemia komanso zotumphukira monga disulfiram.
• mukumwa mankhwalawa, zizindikiro za vitamini B12 hypovitaminosis zimayamba, uku ndi kusinthanso,
• ndi monotherapy ndi mutha kuyendetsa galimoto ndimayendedwe owopsa, koma akaphatikizidwa ndi mankhwala ena, muyenera kupewa kuyendetsa, popeza kuti chidwi chimachepa ndipo liwiro la ma psychomotor limawonjezeka.

Pa nthawi yoyembekezera

Metformin-Teva ndi yoletsedwa kugwiritsidwa ntchito panthawi yoyembekezera komanso yoyamwitsa. Mukakonzekera kutenga pakati kapena kubereka, mankhwalawa amathetsedwa, ndipo wodwalayo amapatsidwa insulin. Palibe chidziwitso chokhudza kuti mkaka wa m'mawere umachotsedwa, chifukwa chake, pakubala, ndibwino kukana kumwa mankhwalawo.

Muubwana

Malangizo ogwiritsira ntchito ali ndi chidziwitso chomwe Metformin-Teva contraindified kuti azigwiritsa ntchito ana ndi achinyamata ochepera zaka 18. Ichi ndichifukwa cha zoyipa zomwe zimagwiritsidwa ntchito ndi mankhwala m'thupi la mwana. Kumwa mankhwalawa popanda mankhwala a dokotala kumayambitsa hypoglycemia, zizindikiro za lactic acidosis ndi zina zomwe zimapangitsa kuti thupi lizigwira ntchito.

Kutentha kwa Metformin-Teva

Mankhwalawa amadziwika chifukwa cha kupatsa mphamvu kwa chiwindi mu chiwindi, zomwe zimapangitsa kuchepa kwa shuga ndi magazi komanso kuchepa kwa kuchuluka kwa mafuta m'thupi. Chomwe chimagwira sichimalola kuti mphamvu isinthidwe kukhala mafuta, imathandizira kuthana ndi oxidation yamafuta acids ndikuchepetsa kuchuluka kwa mayamwidwe amthupi. Mankhwala Amachepetsa kupanga insulini ndipo amathetsa njala, amasinthitsa kukhathamira kwa glucose, amateteza kulemera kwa thupi.

Zonsezi zimachitika pokhapokha ngati insulin ilibe magazi. Mwa munthu wathanzi, izi zimatha kubweretsa zotsatira zosayembekezeka. Tengani Metformin-Teva pakuchepetsa thupi ndizotheka kwa odwala matenda ashuga okha omwe amadya. Pansi pa chiletso chake ndi maswiti, zipatso zouma, nthochi, pasitala, mbatata, mpunga woyera. Mutha kudya ma buckwheat, lentils, masamba, nyama 1200 kcal patsiku. Kuti muchepetse kunenepa, imwani 500 mg kawiri pa tsiku kwa masiku 18-22. Pakatha mwezi umodzi, maphunzirowo atha kubwereza.

Kuyanjana kwa mankhwala osokoneza bongo

Sikuti kuphatikiza konse kwa Metformin-Teva ndimankhwala ena ndizotetezeka. Muyenera kudziwa bwino zomwe zingachitike chifukwa chosakanikirana:

• Danazole amalimbikitsa kukula kwa hyperglycemia,
• Mowa, zakumwa zokhala ndi zakumwa zoledzeretsa, zotupa zodontha, ma ayodini omwe amakhala ndi ayodini kumaonjezera ngozi ya lactic acidosis,
• beta-adrenomimetics jekeseni amachepetsa hypoglycemic zotsatira za mankhwala, angiotensin-kutembenuza enzyme zoletsa ndi antihypertensive mankhwala kuchepetsa shuga,
• zotumphukira za sulfonylureas, Mlingo wa insulin, acarbose ndi salicylates zimachulukitsa zotsatira za hypoglycemic, mankhwala omwe si a antiidal anti-kutupa amawonjezera chiopsezo cha kuchepa kwa impso, kukula kwa hypovitaminosis.

Zotsatira zoyipa

Mukamamwa Metformin-Teva, odwala amatha kukumana ndi zovuta monga.

• kutaya kwa kukoma, nseru,
• kupweteka m'mimba, kusanza,
• kusowa kwa chakudya, hepatitis (padera),
• thupi lawo siligwirizana, erythema,
• kuyamba lactic acidosis (kumafuna discontinuation ya mankhwala), vitamini B12 hypovitaminosis (samachitika kawirikawiri chifukwa cha kugwiritsidwa ntchito kwa nthawi yayitali komanso kuperewera kwa vitamini).

Bongo

Zizindikiro za bongo ndi kukula kwa hypoglycemia ndi lactic acidosis. Zizindikiro zake zimaphatikizapo nseru, kutsegula m'mimba, kusanza, kupweteka m'mimba ndi minofu, komanso kuchepa kwa kutentha. Wodwala amatha kupumira pafupipafupi, chizungulire chimayamba, amalephera kuzindikira, amagwa. Zizindikiro zoyambirira za mankhwala osokoneza bongo zitawoneka, ndikofunikira kusiya mankhwalawo, kutumiza wodwala kuchipatala ndikuwonetsa hemodialysis.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mapiritsi a Metformin-Teva amapezeka mu mitundu yosiyanasiyana - 500, 850 ndi 1000 mg ya metformin imodzi.

Kuphatikiza apo, makonzedwe ake ali ndi zinthu zothandiza:

• Copovidone - cholumikizira chinthu popanga chinthu chomwe chimafunikira,
• polyvidone - imakhala ndi hydrating (imadzaza ndi madzi), imathandiza kuchotsa poizoni, imayendetsa impso,
• microcrystalline cellulose - amakhala ndi shuga m'magazi, amatulutsa shuga, amasintha magwiridwe antchito a impso ndi thirakiti la m'mimba,
• Aerosil - sorbent yomwe imakuthandizani kuti muchotse bwino mapuloteni, omwe amathandizira kuti thupi lizitsuka,
• magnesium yakubayo - filler,
• Opadry II ndi gawo lothandizira mafilimu.

Phukusi la makatoni limakhala ndi matuza atatu kapena asanu ndi mmodzi a mapiritsi khumi limodzi. Mawonekedwe amatha kukhala ozungulira (500 mg) kapena otalika (850 ndi 1000 mg).

Pharmacological kanthu, pharmacodynamics ndi pharmacokinetics

Zotsatira za mankhwala zimayikidwa ndi pharmacological zotsatira zake zazikulu yogwira mankhwala - biguanide. Mtundu wangwiro wa chinthucho (guanidine), womwe umapezeka poyamba, unali wowopsa kwambiri kwa minyewa ya chiwindi. Koma mawonekedwe ake ophatikizidwa akuphatikizidwa pamndandanda wamankhwala ofunikira ndi World Health Organisation.

Zomwe zimayambitsa biguanide zimayambitsa:

• kusintha kwa kagayidwe kazachilengedwe,
• kukhalabe ndi glycemia (shuga m'magazi) mwachizolowezi,
• kukonza zotuluka za shuga kuchokera ku adipose ndi minofu minofu,
• kuchuluka kwa insulin
• kusinthanso kwa magazi kuundana.

"Metformin-Teva" ndi othandizira pa hypoglycemic, komabe, panthawi yochepa kapena yabwinobwino kwambiri ya insulin, ntchito yake imayendetsedwa.

Ma pharmacodynamics a mankhwalawa ndikuchepetsa kupanga shuga m'magazi. Komanso, Metformin-Teva sichimayambitsa hypoglycemia. Pa nthawi ya mankhwalawa, lactic acidosis sichimachitika (plasma poyizoni ndi lactic acid), ntchito ya pancreatic siikakamizidwa. Kuphatikiza apo, mankhwalawa amachepetsa cholesterol, amachepetsa ntchito ya insulin popanga minofu yamafuta, yomwe imathandizira kuchepetsa kulemera.
"Metformin-Teva" imathandizanso kuti mitsempha iwonongeke, motero imakhudza mtima wathunthu.

Mankhwalawa ali ndi pharmacokinetics pang'onopang'ono chifukwa chochepa kwambiri chomanga m'mapuloteni a magazi. Ndende ya Plasma imafika patali patatha maola 2-3 kuyambira nthawi yoyendetsera, komanso ndende yolingana - osapitilira masiku awiri. "Metformin-Teva" amachotsedwa m'thupi kudzera mu impso osasinthika. Chifukwa chake, mwa anthu omwe ali ndi chisokonezo pakugwira ntchito kwa thupilo, metformin imatha kudzikundikira mumsana ndi chiwindi. Hafu ya moyo siipitilira maola 12.

Kodi mankhwalawa ndi mankhwala otani?

Mapiritsi a Metformin-Teva amaperekedwa kwa odwala omwe ali ndi matenda a shuga a 2 opanda vuto la ketoacid. Mankhwalawa amagwiritsidwa ntchito ngati sipangakhale kusintha kulikonse pakudya kapena kudya kwambiri anthu omwe amakonda kunenepa kwambiri. Ndizothekanso kuphatikiza mankhwalawo ndi insulin kwa odwala omwe ataya chidwi ndi insulin.

Kuyenderana ndi mowa

Kumwa mankhwala a Metformin-Teva sikugwirizana ndi mowa. Chifukwa chotenga kuchuluka kwake, pamakhala ngozi ya lactic acidosis, zotsatira zake zomwe zingayambitse zotsatira zosatsimikizika, ngakhale imfa.

Contraindication, mavuto komanso bongo

Mankhwala ali ndi zingapo zotsutsana:

• tsankho ku zilizonse za mankhwala.
• chiwindi kapena impso ntchito, osakwanira creatinine,
• kuchuluka kwa okosijeni m'magazi,
• mtundu uliwonse wa matenda opatsirana
• kusowa kwamadzi
• opaleshoni ndi kuvulala kwakukulu,
• uchidakwa wambiri,
• kudya zakudya zochepa zopatsa mphamvu za tsiku ndi tsiku (zosakwana chikwi)
• kusintha kosangalatsa kwa asidi momwe mungakulitse acidity,
• ketoacidosis
• mimba kapena mkaka wa m`mawere.

M'pofunika kukana kumwa mankhwalawa maola 48 isanachitike komanso mutatha kuphunzira mtundu wina uliwonse.

Zotsatira zoyipa ndizotheka mosiyanasiyana.

1. Kuchokera m'mimba thirakiti. Kuchepetsa msana kapena kusanza, kupangika kwa gasi, kutsegula m'mimba, kuchepa kwambiri kwa kulemera kwa anorexia (zotsatira zimatengera kulemera koyambirira kwa wodwalayo), kupweteka pamimba pamatumbo amtundu wina (kulimba kumatha kufupikitsidwa ngati mukukonzekera phwando limodzi ndi chakudya), kukoma kwachitsulo.
2. Kuchokera ku hemopoietic dongosolo. Kuchepa magazi m'thupi kumagwirizanitsidwa ndi kuchepa (kapena kuyamwa bwino) vitamini B12.
3. Kuchokera kagayidwe kachakudya ka thupi. Kutsika kwa matenda a m'magazi a m'magazi.
4. Kuchokera pa dermis. Chotupa kapena dermatitis.

Mankhwala osokoneza bongo amatha chifukwa cha kuphwanya kuchuluka kwa mankhwala omwe amagwiritsidwa ntchito. Zotsatira zake zitha kukhala aerobic (mtundu B) acidosis.

Kupanga ndi mawonekedwe a kumasulidwa

Metformin teva

Amapezeka mu milingo ya 500, 850 ndi 1000 mg yogwira piritsi imodzi.

• Kuphatikizika kwa zosakaniza zina ndizofanana, kusiyana kokha kuli mu kuchuluka kwa zothandizira: povidone (K30 ndi K90), Aerosil, E572.
• Zigawo za Shell: E464, E171, macrogol.

Mankhwala omwe amakhala ndi mtundu wofanana ndi wochoka mu zinthuzo amaperekedwa m'mapiritsi mu chipolopolo. Mapiritsiwo ndi oyera kapena oyera, ozungulira. Kusiyanitsa zomwe zili panthaka pali chizindikiro china:

• Mapiritsi a 500 mg: zikuto za manambala 93 ndi 48.
• Mapiritsi a 850 mg Metformin-Teva: olembedwa 93 ndi 49.
• Mapiritsi a 1000 mg: zoopsa zimagwiritsidwa ntchito mbali zonse ziwiri. Pamalo amodzi, manambala "93" ali mbali zonse za Mzere, mbali ina - kumanzere kwa Mzere - chithunzi cha "72", kumanja - "14".

Mapiritsi amadzaza m'matumba a zidutswa 10. Mumapaketi a makatoni akuda - 3 kapena 6 ma plates pamodzi ndi khumbo.

Metformin MV Teva

Mapiritsi akumasulidwa pang'onopang'ono kwa chinthu - mapiritsi oyera kapena oyera. Malo okhala ndi zilembo nambala 93 ndi 7267. Chochitikacho chimadzaza ndi zidutswa 10 m'matumba. Phukusi la makatoni - ma mbale atatu kapena 6, malangizo ogwiritsira ntchito.

Kuchiritsa katundu

Mphamvu ya hypoglycemic ya mankhwalawa imatheka chifukwa cha zinthu zake zazikuluzikulu, metformin, yomwe ili m'gulu la Biguanides. Pambuyo kulowa mkati mwa thupi, zimathandizira kuchepetsa kuchuluka kwa shuga ndikumakanikizira kapangidwe kake ndi chiwindi, ndikuchepetsa kuyamwa kuchokera m'mimba, ndikulimbikitsa kugwiritsidwa ntchito mu magawo a minofu ndikukulitsa chidwi chake ku insulin.

Metformin sikukhudza kupanga kwa insulin mthupi, chifukwa chake sikumayambitsa zochitika zosafunikira. Zimakhudza bwino zomwe zili mu cholesterol, kuchuluka kwa TG, lipoprotins.

Mutatenga mapiritsi, mankhwalawa amatengeka msanga, nsonga zake zapamwamba zimapangidwa maola 2,5 pambuyo pa kukhazikitsa. Kutalika kwa kuchitapo kanthu pafupifupi maola 7. Kugwiritsira ntchito limodzi ndi chakudya kumachepetsa kuyamwa kwa metformin. Vutoli limatha kudzikundikira mu tiziwalo tating'ono, impso ndi chiwindi, ndipo limathira mkodzo.

Njira yogwiritsira ntchito

Mtengo wapakati: 0,5 g (ma 30 ma PC.) - 110 ma rub., (Ma 60 ma PC.) - 178 ma rub., 0.85 g (ma 30 ma PC.) - 118 rub., (60 ma PC.) - 226 rub. , 1 g (mapiritsi 30) - ma ruble 166, (mapiritsi 60) - 272 ma ruble.

Mapiritsi a Metformin ayenera kumwedwa mogwirizana ndi malangizo ogwiritsira ntchito kapena mogwirizana ndi cholinga chachipatala. Ndikulimbikitsidwa kuti muziphatikiza ndi chakudya kapena chakumwa mukangodya.

Ngati wodwalayo amamwa mapilitsi nthawi yoyamba, ndiye kuti nthawi zambiri amakupatsani mlingo woyambira tsiku lililonse kuchokera 500 mg mpaka 1 g. Ngati pambuyo pa masabata 1-2 atapezeka kuti sagwira ntchito, amatha kuonjezeredwa, kumwa kamodzi m'mawa komanso asanagone. M'tsogolomu, njirayi imasinthidwa ndi katswiri malinga ndi kuchuluka kwa glycemia wodwala.

Kukonzekera mlingo: 1.5 mpaka 2 g wa metformin. Kuchuluka kwake ndi 3 g, yogawidwa pazidutswa zitatu.

Ngati wodwalayo adatenga kale mankhwala ena ochepetsa shuga, ndiye kuti Metformin amayamba kumwa kuchuluka kofanana ndi mlingo wapitawu.

Akaphatikizidwa ndi insulin, CH choyambirira ndi 500-850 mg mu milingo ingapo. Kuchuluka kwa insulin kumawerengeredwa molingana ndi glycemia ndikuganizira mlingo wa metformin. Pambuyo masiku 10-15 mutayamba maphunziro, mungathe kukonza mankhwalawa.

Metformin MV Teva

Mtengo wapakatikati: (ma ma 30 ma PC.) - 151 rub., (Ma 60 ma PC.) - 269 rub.

Mapiritsi amatengedwa pakamwa nthawi yomweyo ngati chakudya kapena nthawi yomweyo chakudya. Mlingo woyambirira ndi piritsi limodzi. (500 mg). Ngati pakatha milungu iwiri vutoli silikuyenda bwino, ndiye kuti kuchuluka kwa mankhwalawa kungathe kubwerezedwanso. Pankhaniyi, piritsi limodzi latengedwa. m'mawa ndi madzulo. Kuchuluka kwakukulu komwe kungatengedwe kamodzi patsiku ndi 2 g (mapiritsi 4, 500 mg aliyense).

Mapiritsi otsekemera otsekemera amatha kuphatikizidwa ndi insulin. Mlingo wa mankhwalawa koyambirira kwa piritsi limodzi, lomwe limasinthidwa pambuyo pa masabata awiri. Kuchuluka kwa insulini kumasankhidwa kutengera mtundu wa glycemia. Metformin CH yokhala pang'ono pang'onopang'ono ndi maphunziro athunthu - 2 g awiri Mlingo wogaanika.

M'mimba komanso HB

Mapiritsi a Metformin (omwe amatulutsidwa ndi zinthu zina pang'onopang'ono) amaletsedwa panthawi ya bere. Amayi omwe amafunafuna kukhala amayi, ndikofunikira pakukonzekera kusiya mankhwalawa, pogwiritsa ntchito zina zomwe dokotala angalembe. Wodwala ayenera kudziwa kufunika kwa mankhwalawa ngati angatsimikizire kuti ali ndi pakati. Ngati amayi apezeka kuti ali ndi pakati pa mankhwala, ndiye kuti mankhwalawo ayenera kuthetsedwera ndi kufunsa dokotala kuti asankhe m'malo mwake. Wodwalayo amayenera kuyang'aniridwa ndi achipatala kuti akalandire.

Sizikudziwika ngati metformin ilowa mkaka wa m'mawere kapena ayi, chifukwa chake, pofuna kupewa kuvulaza mwana, muyenera kusiyira mkaka wa nthawi ya mkaka.

Kuchita mankhwala osokoneza bongo

Mukamamwa Metformin Teva, ziyenera kukumbukiridwa kuti zomwe zimagwira zimatha kugwiranso ntchito ndi zigawo zina za mankhwala ena.

• Mankhwalawa aletsedwa kumwa ndi ayodini amene amagwiritsidwa ntchito m'maphunziro a radiology. Kuphatikiza uku kumayambitsa lactic acidosis. Ngati ndi kotheka, njira ya metformin iyenera kuchotsedwa masiku awiri isanachitike ndikuti isatengeredwe pakamwa nthawi yomweyo.
• Kugwiritsa ntchito mankhwala osokoneza bongo omwe ali ndi mowa kapena mankhwala okhala ndi ethanol kumawonjezera chiopsezo cha lactic coma panthawi ya poizoni wakumwa.
• Akaphatikizidwa ndi Diazole, malo omwe ali ndi hypoglycemia amalimbikitsidwa. Chifukwa chake, ngati kuli kotheka, kugwiritsa ntchito mankhwala paliponse, ndikofunikira kusintha mlingo wa mankhwalawa.
• Chlopromazine amatha kuwonjezera shuga ndikuchepetsa mapangidwe a insulin.
• GCS imatha kuchepetsa kulolera kwa shuga, ndikuchulukitsa, ndikupatsanso ketosis.
• Akaphatikizidwa ndi mankhwala a diuretic (makamaka ozungulira diuretics), zovuta zama impso zimakulitsidwa ndipo lactic acidosis imakwiya.
• Beta-2-adrenergic agonists amathandizira pakuwonjezeka kwa glycemia. Ngati ndi kotheka, mankhwala a insulin amagwiritsidwa ntchito.

Popereka mankhwala a Metformin, wodwalayo ayenera kufotokozera onse mankhwala omwe amayenera kumwa kuti adokotala adziwe kuthekera kwa kuphatikiza kwawo, ndipo ngati kuli koyenera, asinthe momwe amathandizira. Zomwezi zikuyenera kuchitika ngati mkati mwa hypoglycemic maphunziro a metformin atakhala ndi matenda aliwonse ndipo amafuna mankhwala ena.

Zotsatira zoyipa ndi bongo

Chithandizo chamankhwala okhala ndi mapiritsi wamba ndi Metformin MV Teva imatha kutsatiridwa ndi zovuta, zowonetsedwa mosiyanasiyana. Zotsatira zosafunikira zimawoneka ngati:

• CNS: zotsekemera zosokoneza, "zitsulo" zamtundu wina
• Ziwalo zogaya chakudya: nseru, kusanza, kupweteka, kusowa kudya (komwe kwa magawo oyambilira kumwa mapiritsi, matendawo amadzichitira okha, popanda zina zowonjezera), kawirikawiri, pakadutsa pakumwa mankhwala - kulephera kwa magwiridwe antchito a chiwindi, chiwindi
• Mawonekedwe a matupi awo: erythema, totupa, kuyabwa
• Njira za metabolabolic: lactic acidosis (ndiye chizindikiro cha kuthetsedwa kwa metformin)
• Zophwanya zina: nthawi zina, mutagwiritsidwa ntchito kwa nthawi yayitali - kusowa kwa vit. B12.

Pogwiritsa ntchito mapiritsi 10 nthawi kuchuluka kwake kudutsa (85 g), hypoglycemia sizinachitike, koma adathandizira kupanga lactic acidosis. Ngati mukukayikira kuti wodwala wamwa mankhwala ochuluka, muyenera kuyang'anira ngati ali ndi zizindikiro zoyambira za matenda. Kukhazikika kwa lactic coma kumadziwika ndi mseru wamphamvu, kusanza, kupweteka m'misempha ndi m'mimba, komanso kutsika kwa kutentha. Ngati zizindikirozi zikunyalanyazidwa, kuwonongeka kwina kwa vuto la wodwalayo ndikotheka: kulephera kupuma, chizungulire, kukomoka. Woopsa akadwala, amatha kudwala.

Pofuna kupewa ngozi yomwe ingawononge moyo wanu, mankhwalawo ayenera kuchotsedwa mwachangu, ndipo wodwalayo ayenera kuchipatala mwachangu. Ndi chitsimikiziro cha lactic acidosis, hemodialysis ndi mankhwala, symptomatic mankhwala.

Mutha kuwongolera kuchuluka kwa glucose mothandizidwa ndi mankhwala ena. Kuti musankhe mankhwala okhala ndi zochita zofanana ndi Metformin, muyenera kulumikizana ndi dokotala.

Metfogamma

Woerwag Pharma (Germany)

Mtengo wapakati: 500 mg (mapiritsi a 120) - ma ruble 324, 850 mg (matani 30) - ma ruble 139, (matani 120) - 329 rubles.

Mankhwala a Metformin okhala ndi shuga. Zimapangidwa ndizosiyanasiyana piritsi limodzi. Mankhwalawa adapangira anthu omwe ali ndi matenda a shuga omwe amadalira insulin.

Chithandizo chimayamba ndi mlingo wocheperako, pakatha milungu iwiri yothandizira, imatha kuwonjezeka malinga ndi mawonekedwe.

Ubwino:

• Amathandiza ndi matenda ashuga
• Zimathandizira kuwonda
• Khalidwe labwino kwambiri.

Metformin MV-Teva

Mankhwalawa amapezeka mu mlingo wa 500 mg, 60 zidutswa pa paketi iliyonse. Imakhala ndi nthawi yayitali pokhudzana ndi mankhwala. Mtengo wa maphunzirowa ulibe kusiyana kowoneka.

Mankhwalawa ali ndi metformin mu Mlingo wofanana ndi mankhwala a Metformin-Teva. Komabe, mphamvu ya Glucophage ndiyabwino chifukwa chosakhalapo ambiri omwe amapezeka piritsi. Chifukwa cha izi, kuphatikiza pa mwayi wochepetsa mulingo (monga momwe amavomerezerana ndi othandizira), mankhwalawa ali ndi zotsatirapo zingapo zoyipa kuchokera m'matumbo am'mimba.

Bagomet, Glycomet, Dianormet, Diaformin

Mtheradi analogi wa mankhwala "Metformin-Teva" mu ndende ndi kupangidwa kwa yogwira thunthu. Komabe, pali zosiyana pamndandanda wazopeza zomwe sizili ndi tanthauzo lalikulu pa pharmacokinetics. Chifukwa chake, kuwonjezera pa kusiyana pang'ono pa mtengo, palibe kusiyana ndi Metformin-Teva.

Kutalika kwa Combogliz

Mankhwala omwe amaphatikiza mankhwala awiri othandizira odwala matenda osiyanasiyana. Metfomin ndi biguanide yomwe imachepetsa kuchuluka kwa insulin yomangidwa ndikuwonjezera zomwe zimatuluka m'thupi. Saxagliptin ndi chinthu chomwe chimapondereza ma enzymes ena komanso kuwonjezera nthawi ya mahomoni omwe amathandizira kupanga insulin. Kuphatikiza mzake, zinthu zomwe zimagwira zimapereka kumasulidwa kosintha. Izi zikutanthauza kuti mankhwalawa amakhudzana ndi zina. Chifukwa chake, kugwiritsidwa ntchito kwake ndizotheka popanda zovuta komanso ndi zochepa zotsutsana. Mosakayikira, "Combogliz Pronge" imakhala yothandiza kwambiri. Komabe, ndi m'badwo wotsatira wa mankhwala omwe amapangidwa pochiza matenda amtundu wa 2 shuga.

"Metformin-Teva" ndi mankhwala othandiza pochiza matenda a shuga a mtundu wachiwiri. Mtengo wake ndizovomerezeka, ndipo ntchito yofunikayi idawerengedwa ndikutsimikiziridwa ndi maphunziro ambiri.