Momwe mungagwiritsire ntchito mankhwala Combogliz Prolong?

Kuphatikizidwa kwa metformin ndi DPP4 inhibitors (glyptins) kumadziwika ndi endocrinologists monga oganiza bwino kwambiri amitundu yachiwiri ya matenda ashuga. Zinthu zomwe zimawerengedwa kwambiri kuchokera ku kalasi la gliptins ndi saxagliptin. Pulogalamu ya saxagliptin yokhala ndi metformin yokhazikika piritsi limodzi idagulitsidwa mu 2013 pansi pa dzina la Combogliz Prolong.

Zomwe zimagwiritsidwa ntchito pazomwe zimapangidwira zimakhala ndi mphamvu yowonjezera: zimachepetsa kukana kwa insulini ndikupanga insulin. Komanso, mankhwalawa atsimikizira kutetezeka kwa mtima ndi mitsempha ya magazi, kwenikweni sikuti amayambitsa hypoglycemia, sikuti zimapangitsa kuti munthu achuluke. Ma algorithms apamtima amalimbikitsa kutenga Combogliz Prolong kwa odwala omwe ali ndi vuto la insulin. Ndi glycated hemoglobin pamwambapa 9%, imatha kutumikiridwa atangozindikira matenda a shuga.

Limagwirira ntchito comboglize

Combogliz Prolong ndi mankhwala aku America, ufulu wake ndi wa makampani a Bristol Myers ndi Astra Zeneka. Mapiritsi ali ndi zosankha zitatu, zomwe zimapangitsa kusankha kuchuluka kwa metformin ndi saxagliptin kutengera mawonekedwe a matendawa:

• 1000 mg + 2.5 mg ndi yoyenera kwa odwala matenda ashuga omwe ali ndi vuto lalikulu la insulin, kunenepa kwambiri, ntchito zamagalimoto ochepa,
• 1000 mg + 5 mg - njira yodziwika bwino kwa odwala matenda a shuga omwe ali ndi kuchepa kwa insulin kapenanso kuwonda pang'ono,
• 500 + 5 mg imagwiritsidwa ntchito kumayambiriro kwa mankhwalawa ndi Combogliz Prolong, pang'onopang'ono imatha kugwiritsidwa ntchito ndikulimbana ndi insulin pang'ono, thupi loyenera.

Pakuwona kufanana kwa Combogliz ndi zigawo zake, metformin ndi saxagliptin, zidapezeka kuti palibe kusiyana mu pharmacokinetics ya mankhwalawa, kuphatikiza kwa zinthu ziwiri papiritsi limodzi sikumayipa mphamvu zomwe aliyense wa iwo ali nazo, momwe matendawa amakhudzira matenda a shuga.

Nthawi yomweyo, kuphatikiza mankhwala okhazikika kumawoneka ngati kothandiza kwambiri kuposa kumwa mankhwalawo mosiyana. Izi ndichifukwa chowonjezeka pakutsatira chithandizo, mawuwa amatanthauza kutsatira malangizo onse a dokotala. M'matenda osachiritsika, monga matenda a shuga, ndimakhala otsika kwambiri: odwala amaiwala kumwa mapiritsi ena, kapena amangosiya kumwa mankhwala omwe amapezeka. Kafukufuku akuwonetsa kuti njira zosavuta zochizira zimathandizira, zomwe dokotala angachite bwino. Kusintha kwa metformin ndi saxagliptin padera kupita ku Combogliz Prolong kumakupatsani mwayi wotsitsa hemoglobin wa glycated ndi 0.53%.

Kwa zaka zambiri, ndi metformin yomwe imalimbikitsidwa ndi mabungwe ashuga kuti ikhale yoyambirira. Izi ndichifukwa choti metformin imachita pazomwe zimayambitsa matenda a diabetes a 2 - matenda a insulin. Malinga ndi malangizo, glycemia kuchepetsa matenda ashuga kumachitika chifukwa:

• kuponderezedwa kwa shuga m'thupi (gluconeogeneis, pang'ono - glycogenolysis),
• Kuchepetsa mayamwidwe a shuga mumimba,
• kuonjezera magwiridwe a insulin mu minofu, makamaka minofu.

Kuchita bwino kwa mankhwala ochepetsa shuga nthawi zambiri kumawunikidwa ndi kutsika kwa hemoglobin wa glycated akamatengedwa. Kwa metformin, chizindikirochi ndichokwera kwambiri - 1-2%. Mankhwalawa salowerera pa kulemera kwa zaka zoposa 10, makulitsidwe ambiri odwala matenda ashuga anali 1 kg, omwe ndi ochepa poyerekeza ndi chithandizo cha insulin komanso zotumphukira za sulfonylurea.

Tsoka ilo, chithandizo ndi metformin sichotheka nthawi zonse chifukwa cha zovuta zake - kusamva bwino m'mimba, kutsegula m'mimba, matenda m'mawa. Kupititsa patsogolo kulekerera kwa mankhwalawa, adayamba kumasulidwa mwanjira ya mapiritsi ndikutulutsidwa (kutalikitsidwa). Ndi metformin yotere yomwe ili mu Comboglize Prolong. Piritsi ili ndi mawonekedwe apadera: zinthu zomwe zimayikidwa zimayikidwa mu matrix yomwe imamwa madzi. Pambuyo pa makonzedwe, matrix amasintha kukhala gel, yomwe imapangitsa kuti Metformin asachedwe kuyenda kuchokera m'magazi. Kuchepetsa mphamvu ya shuga kumakhala motere mpaka maola 24, chifukwa chake malangizo omwe angagwiritsidwe ntchito amalimbikitsa kumwa mapiritsi kamodzi patsiku.

Saxagliptin

Gawoli la Comboglize Prolong limayang'anira kusintha kwa insulin. Makina a zochita za saxagliptin ndi zoletsa za enzyme DPP-4, gawo lawo lomwe kumatanthauzira ma insretins. Ma incretins amapangidwa ndi glycemia yowonjezereka ndikuthandizira kuwonjezeka kwa kupanga amkati a insulin. Mukamachepetsa mphamvu ya DPP-4, ma insretin adzagwira ntchito nthawi yayitali, kuphatikiza kwa insulini kumachulukanso, magazi a m'magazi amatsika.

Ubwino wa mankhwalawa ndi ubale wa glucose m'magazi ndikupanga insulin. Zomwe zimachokera ku sulfonylurea zilibe ubale wotere. Ngakhale muyezo waukulu, saxagliptin sangatalikitse moyo wa ma protein nthawi zopitilira 2, kotero kuchepa kwake kwa shuga kumachepa pakapita nthawi ndipo sikuti kumayambitsa hypoglycemia. Palibe kuchepa kowopsa kamodzi kwa glucose pakugwiritsa ntchito komwe kunalembedwa. Kusamala kwa saxagliptin kwa maselo a beta omwe amapanga insulini kumathandizira kuwonjezera ntchito yawo ndikuchedwetsa kuikidwa kwa insulin, yomwe singapewere matenda ashuga.

Onse metformin ndi saxacgliptin amachepetsa kulowa kwa glucose kuchokera m'mimba m'matumbo. Malinga ndi odwala matenda ashuga, mankhwalawa onse amachepetsa kudya komanso amalimbikitsa kukhuthala, motero Combogliz Pronge ndiye chisankho chabwino kwambiri kwa odwala omwe ali onenepa kwambiri, mosiyana ndi kuphatikiza kwa metformin ndi sulfonylurea.

Chojambula chokhacho chomwe sichingagulitsidwe ndi saxagliptin ndi mtengo wake, womwe ndi dongosolo lokwezeka kwambiri kuposa zokonzekera zotsika mtengo za sulfonylurea.

Zothandiza

Kuphatikiza pazinthu zomwe zimagwira, mapiritsi a Combogliz Prolong alinso ndi zinthu zina zomwe zimathandizira kupanga ndikupereka nthawi yayitali ya metformin. Monga gawo lamkati, kapena matrix, magnesium stearate, hypromellose, carmellose. Mapiritsiwo ali ndi zipolopolo zitatu za Opadrai, zopangidwa ndi talc, titanium oxide, macrogol. Chapamwamba chimakhala ndi utoto - ironideide.

Mlingo wosiyanasiyana umasiyana ndi utoto: 2,5 + 1000 mg chikasu, 5 + 500 beige, 5 + 1000 pinki. Piritsi lililonse, mlingo woyenera umagwiritsidwa ntchito ndi utoto wabuluu.

Zothandizira zothandizira zimaphatikizidwa pamodzi ndi ndowe mu mawonekedwe ofewa, zimatha kukhala ngati piritsi. Palibenso zinthu zina zomwe zingagwire ntchito pa misa.

Alumali moyo wa Comboglize Prolong ndi zaka 3. Zofunikira zomwe wopangayo azisungira ndi kutentha mpaka madigiri 30.

Mtengo wa ma CD umachokera ku 3150 mpaka 3900 rubles. kutengera kuchuluka kwa mapiritsi a paketi (28 kapena 56 ma PC) ndi mlingo.

Malangizo a kumwa mankhwalawa

Mlingo wovomerezeka wa saxagliptin wa odwala matenda ashuga ambiri ndi 5 mg. Mlingo wocheperako wa 2.5 mg umaperekedwa chifukwa cha kulephera kwa impso ndi GFR osakwana 50, komanso kumwa mankhwala ena a antifungal, antibacterial and antiretroviral omwe amathandizira pakuwonjezeka kwa kuchuluka kwa saxagliptin m'magazi.

Mlingo wa metformin amasankhidwa payekha kutengera mulingo wa kukana insulini. Kwa theka loyamba la mwezi, odwala matenda a shuga amamwa piritsi limodzi lokhala ndi 5 + 500 mg.

Kumayambiriro kwa chithandizo, chiopsezo cha zovuta za metformin ndizambiri. Kuti muchepetse, mankhwalawa amatengedwa ndi chakudya, makamaka madzulo. Ngati metformin imalekerera bwino, pambuyo pa masabata awiri mlingo wake umakulitsidwa mpaka 1000 mg. Saxagliptin waledzera pa mlingo womwewo. Ngati pakumveka kosangalatsa m'matumbo am'mimba, kuwonjezereka kwa mankhwalawa kuyenera kuikidwa kaye ndipo nthawi yochulukirapo iyenera kuperekedwa kwa thupi kuti lizolowere mankhwalawa. Ngati glycemia ili yachilendo, Combogliz Prolong imatha kutengedwa muyezo womwewo kwa zaka zingapo osataya mphamvu.

Mlingo wololedwa kwambiri wa Comboglize ndi 5 + 2000 mg. Amaperekedwa ndi mapiritsi awiri a 2,5 + 1000 mg, aledzera nthawi yomweyo. Ngati 2000 mg ya metformin yodwala matenda a shuga sikokwanira, 1000 mg imodzi imatha kutengedwa mosiyana, makamaka mu mawonekedwe omwewo (Glucofage Long ndi analogues: Formin Long, Metformin MV, etc.).

Kuonetsetsa kuti machitidwe omwe ali ofanana azigwira, mankhwalawa amamwa nthawi yomweyo. Kusunga katundu wautali, mapiritsi sangaphwanyidwe.

Momwe mungasinthire Combogliz Kutalika

Ma genetic ku Combogliz Prolong sakhalapo ndipo sadzaonekera posachedwa, popeza patent idakutidwa ndi mankhwalawa. Ma analogues a gulu ndi linagliptin gliptins (kuphatikiza ndi metformin kumapangidwa pansi pa chizindikiro cha Gentadueto), vildagliptin (mankhwala osakanikirana a Galvus Met), sitagliptin (Velmetia, Yanumet). Zotsatira zawo mu shuga mellitus zimayandikira kwambiri saxagliptin, koma zinthu zimasiyana mosiyanasiyana, pharmacokinetics, contraindication, kotero kusintha kwa mankhwala atsopano kuyenera kuvomerezedwa ndi dokotala.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russia Academy of Medical Science idatha kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka Meyi 18 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

Momwe mungasungire pa kugula kwa Combogliz Kutalika:

1. "Sungani" Combogliz Kutalika kuchokera kwa Onglisa ndi Metformin. Onglisa - mankhwala a omwe amapanga, ali ndi 2.5 kapena 5 mg wa saxagliptin. Mtengo wake ndi 1800 rubles. mapiritsi 30 a 5 mg. Kuti mubwereze kwathunthu kapangidwe ka Combogliz Prolong, metformin yotalikilapo imawonjezeredwa kwa Ongliz, m'mwezi umodzi adzagula rubles 250-750.
2. Funsani dokotala wanu kuti akupatseni mankhwala aulere a saxagliptin. Mankhwalawa mwina sangakhalepo m'magawo onse, koma kuchuluka kwawo kukukula chaka chilichonse. Chizindikiro cha saxagliptin - pafupipafupi kapena kwambiri hypoglycemia pa sulfonylurea. Popeza mankhwalawo alibe zamagetsi zotsika mtengo, mankhwalawa angakupatseni mapiritsi akale a Combogliz Prolong, kapena metformin ndi Onglizu.
3. Ngati mungayitanitse mankhwalawo mankhwala ogulitsa pa intaneti ndikusankha nokha kuchokera pazomwe zingatheke, mutha kusunga pafupifupi 10% ya mtengo wake.

Kusinthira kuzomwe zimachokera ku sulfonylurea ndizosayenera chifukwa zingayambitse hypoglycemia. Ngati palibe njira ina, ndibwino kutenga glimepiride yotetezeka kwambiri ndi gliclazide. Mndandanda wa mankhwala Combogliz okhala ndi zinthu izi - Amaril M, Glimecomb.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, mapiritsi a Combogliz Prolong amapatsidwa mankhwala a shuga a 2, ngati kuwongolera zakudya komanso kuchita masewera olimbitsa thupi sikungachepetsa mokwanira glycemia. Popeza mtengo wokwera wa mankhwalawo, kuchuluka kwake sikocheperako. Malinga ndi endocrinologists, amapereka mankhwala pazochitika zotsatirazi:

1. Ngati wodwala wathetse insulin kaphatikizidwe, ndipo amatenga sulfonylurea amakhala wotsutsana.
2. Pokhala ndi chiopsezo chachikulu cha hypoglycemia: okalamba, odwala matenda ashuga omwe ali ndi matenda ophatikizika komanso zoletsa pazakudya, odwala omwe ali ndi masewera olimbitsa thupi ambiri, olemba ntchito pantchito yomwe imafuna chisamaliro chachikulu.
3. Odwala omwe ali ndi matenda ashuga omwe samatsatira malangizo a dokotala amatha kuiwala kumwa mapiritsi kapena kudya nthawi.
4. Anthu omwe ali ndi matenda ashuga omwe amachepetsa zizindikiro za hypoglycemia.
5. Ngati wodwala yemwe ali ndi matenda ashuga amayesetsa ndi mphamvu zake zonse kuti apewe insulin. Amakhulupirira kuti sulfonylurea imathandizira kuwonongeka kwa maselo a beta. Palibe zambiri zokhudzana ndi sacasagliptin.

Contraindication

Mndandanda wa contraindication mu malangizo a Comboglyz Prolong ndiwowonjezera, monga mankhwala aliwonse:

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapezeka pokhapokha piritsi. M'mawonekedwe, mapiritsiwa ali ofanana ndi makapisozi wamba. Iliyonse mwa iyo imakutidwa ndi chipolopolo chapadera. Mtundu umatengera mlingo. Mapiritsi achikasu ali ndi 1000 mg ya metformin ndi 2,5 mg wa saxagliptin. Mapiritsi a Pinki ali ndi kuchuluka komweko kwa metformin, koma kale 5 mg ya saxagliptin. Mtundu wa bulauni wamakapu umawonetsa kuti ali ndi 500 mg ya metformin ndi 5 mg ya saxagliptin.

Mankhwalawa amapezeka pokhapokha piritsi. M'mawonekedwe, mapiritsiwa ali ofanana ndi makapisozi wamba. Iliyonse mwa iyo imakutidwa ndi chipolopolo chapadera.

Mapiritsiwo ali ndi matuza apadera oteteza. Iliyonse mwa izo, magawo 7. Mtolo wa makatoni ukhoza kukhala ndi matuza 4 mpaka 8. Kuphatikiza apo, phukusi lililonse liyenera kukhala ndi malangizo atsatanetsatane ogwiritsira ntchito.

Zotsatira za pharmacological

Mankhwalawa ali ndi kuphatikiza. Makina onse omwe amagwira ntchito amasulidwa muzosintha zawo.

Kuphatikizidwa kwa mankhwalawa kumakhala ndi magawo awiri othandizira omwe amathandizira kuchitirana.

Metformin ndi njira yabwino kwambiri. Amatha kupondereza kwathunthu njira za gluconeogeneis. Izi zimachepetsa kukhatikiza kwa mafuta ndipo kumachulukitsa chidwi cha insulin receptors. Maselo amayamba kugwiritsa ntchito shuga. Chomwe chimagwira sichikhudzanso kuchuluka kwa insulin m'magazi ndipo sichimayambitsa mikhalidwe ya hypoglycemic.

Chifukwa cha mphamvu ya metformin, kuphatikiza kwa glycogen kumapangidwira. Kusunthidwa ndi kusakanikirana kwa shuga m'maselo kumawonjezeka. Nthawi yomweyo, kuyamwa kwa shuga kwathunthu m'matumbo amachepetsa, chifukwa chake munthu amachepetsa thupi msanga. Magazi oyambira amwazi amayendetsedwa bwino.

Saxagliptin imalimbikitsa kupanga mahomoni a incretin. Pankhaniyi, kutulutsidwa kwa insulini kuchokera ku maselo a beta a kapamba kumawonjezeka, ndipo kupanga glucagon kumatsika kwambiri. Mkulu wama glucose amachepetsa panthawi ya chakudya komanso pamimba yopanda kanthu. Chifukwa cha zomwe pawiri pompopompo, kumverera kwodzaza sikumatha kwa nthawi yayitali, zomwe zimapangitsa kuchepa kwa odwala omwe ali ndi matenda ashuga.

Pharmacokinetics

Saksagliptin nthawi zambiri amasinthidwa kukhala metabolite yeniyeni yogwira.Metformin imachotsedwa osasinthika thupi. Mankhwalawa amatuluka pambuyo pa kuwonongeka kwa impso.

Mankhwalawa amayenera kukhala okwanira ndipo azichitika mogwirizana ndi zakudya komanso kuchita masewera olimbitsa thupi pang'ono.

Mafuta ambiri omwe amapezeka m'magazi amawonedwa patatha maola 7 mutamwa mapiritsi.

Ndi chisamaliro

Mosamala kwambiri, mankhwalawa amayenera kumwa kwa anthu omwe ali ndi matenda a mtima. Wothandizila ena wa hypoglycemic amathandizira kusintha kwa impso. Chifukwa chake, anthu omwe ali ndi vuto la chiwindi komanso matenda a impso akasintha m'mene zovuta zoyambirira zimawonekera zimayenera kusintha kuchuluka kwa mankhwalawa kukhala ochepa.

Momwe mungatengere Combogliz Kutalika

Mlingo wa wodwala aliyense umasankhidwa motsatana. Zonse zimatengera kuuma kwa wodwalayo komanso thanzi lawo.

Madokotala amalimbikitsa kumwa mapiritsiwa kamodzi patsiku.

Ndikofunika kuchita izi nthawi yomweyo. Makapisozi sasuma, ayenera kumezedwa kwathunthu ndikutsukidwa ndi madzi oyera.

Kumayambiriro kwa chithandizo, mumalandira mlingo wochepa. Ngati ndi kotheka, imawonjezedwa pang'onopang'ono kuti muchepetse mwayi wokhala ndi mavuto osafunikira. Mlingo wambiri ungagawidwe mu Mlingo umodzi komanso mobwerezabwereza.

Ndi matenda ashuga

Zochizira matenda a shuga, piritsi limodzi patsiku limayikidwa. Izi zimakhudza kwambiri kuchuluka kwa shuga m'magazi, kumachotsa chizindikiro cha insulin kuchepa kwa thupi. Zizindikiro zoyambirira za kuledzera zitapezeka ndi mankhwala, muyenera kusintha mlingo wake kapena kusiyiratu kugwiritsa ntchito mankhwalawo.

Makapisozi sasuma, ayenera kumezedwa kwathunthu ndikutsukidwa ndi madzi oyera.

Zotsatira zoyipa

Chidacho chimakhala ndi njira zambiri zotsutsana. Ngati simutsatira malamulo onse ogwiritsira ntchito mankhwalawa, izi zimachitika motere:

• kupweteka kwambiri m'mutu
• mkhalidwe wa migraine
• kupweteka m'mimba
• matenda opatsirana omwe amapezeka mu ziwalo za genitourinary system,
• kutsegula m'mimba, kusanza komanso kusanza,
• sinusitis
• Kutupa kwa m'munsi ndi kumaso,
• achina,
• thupi lawo siligwirizana mu urticaria,
• gastroenteritis ndi kapamba,
• chisangalalo
• kuphwanya kulawa kwamalingaliro azakudya.

Kujambula ululu pamimba, kutsekula m'mimba, kusanza ndi kusanza kungakhale zizindikilo za mankhwala.

Zizindikiro zonsezi zimatha kuchotsedwa mothandizidwa ndi dalili. Amazimiridwanso atachotsedwa kwathunthu kwa mankhwalawo.

Gwiritsani ntchito pa nthawi yoyembekezera

Pakubala kwa mwana, kugwiritsa ntchito mankhwalawa osavomerezeka. Izi ndichifukwa choti palibe kafukufuku wokwanira wamankhwala yemwe amatsimikizira kuti mankhwalawa samawonetsa chilichonse cha embilegenic ndi teratogenic. Zingakhudze mapangidwe a mwana wosabadwayo. Chifukwa chake, pakakhala pakati, pakachitika ngozi, ndibwino kusamutsa wodwala kuti akhale ndi insulin yoyenera.

Palibe umboni wonena kuti mankhwalawo amadutsa mkaka wa m'mawere. Chifukwa chake, ngati pakufunika kutero, mankhwalawa ndi bwino kusiya kuyamwa.

Gwiritsani ntchito mu ukalamba

Mankhwalawa amayenera kuperekedwa mosamala kwambiri kwa okalamba. Ali ndi chiopsezo chachikulu chotenga zovuta, kotero, ngati zizindikiro zoyambirira za kuledzera zikuwonekera, muyenera kuwona dokotala kuti musinthe mankhwalawa kapena kusiya mankhwala.

Madokotala ena amapereka mankhwala osokoneza bongo kuti apangitse zotsatira za placebo kukhazikitsa bata la odwala okalamba.

Bongo

Mankhwala osokoneza bongo ndi osowa. Koma ngati mwalandira mwangozi mlingo waukulu wa mankhwalawo, zizindikiro za lactic acidosis zitha kuchitika:

• kulephera kupuma
• minofu kukokana
• kugona ndi kuwawa,
• cramping ndi m'mimba kupweteka
• kununkhira kwa acetone kuchokera mkamwa.

Ndi kukula kwamavuto, wodwalayo amalizidwa kuchipatala ndipo dialysis imakakamizidwa. Mwina chitukuko cha hypoglycemia. Ndi degree yake yofatsa, chakudya chotsekemera chimathandiza. Mwa mawonekedwe owopsa, munthu ayenera kuzindikiridwa ndikupatsidwa jakisoni wa glucagon kapena yankho la dextrose hydrochloride.

Kuchita ndi mankhwala ena

Kuphatikizana ndi ma isoenzymes ena kumachulukitsa kuchuluka kwa lactate m'madzi a m'magazi.

Mankhwala amatha kuthandizanso pazinthu zothandiza:

• magnesium ndi aluminium hydroxide,
• Rifampicin,
• nicotinic acid
• mahomoni ndi chithokomiro,
• okodzetsa
• calcium ion blockers,
• Isoniazid.

Mphamvu ya zinthu zotsatirazi imachepetsedwa kwambiri:

• Mowa
• Furosemide
• Ketoconazole,
• Famotidine
• Glibenclamide,
• Erythromycin,
• Verapamil
• Fluconazole

Katswiriyu ayenera kudziwa zamankhwala onse omwe wodwala amatenga kuti akwaniritse bwino mankhwala.

Katswiriyu ayenera kudziwa zamankhwala onse omwe wodwala amatenga kuti akwaniritse bwino mankhwala.

Kuyenderana ndi mowa

Ndikosayenera kumwa zakumwa zoledzeretsa kwa anthu omwe ali ndi matenda ashuga. Ngati mankhwala a ethanol alipo m'mankhwala aliwonse omwe agwiritsidwa ntchito, onetsetsani kuti mwadziwitsa dokotala za izi ndikulandila malangizo owonjezereka.

Mafananidwe wamba ndi:

• Janumet
• Galvus Met,
• Combogliz
• Glibomet,
• Bagomet.

Mtengo wa Combogliz Kutalika

Mtengo umachokera ku rubles 3,000. Mtengo womaliza umangodalira malire a pharmacy ndi kuchuluka kwa mapiritsi omwe ali phukusi.

Analogue wamba ya Combogliz Pronge ikhoza kukhala Yanumet, mapiritsi othandizira odwala omwe ali ndi matenda a shuga.

Ndemanga za odwala za Comboglize kutalika

Alisa, wazaka 38, ku St. Petersburg: “Posachedwa apeza matenda a shuga. Dotolo adayikira mapiritsi, koma sizinathandize, vuto limangokulirakulira. M'malo mwa Combogliz Kutalika. Zotsatira zake zikuwoneka. Mankhwalawa amathandizira kuti pasakhale shuga wambiri m'njira zovomerezeka. Sindinamve zowawa zilizonse. Kumayambiriro kogwiritsa ntchito komwe kunali chizungulire pang'ono ndi mseru. Mofulumira zokwanira zidutsa. Mankhwalawa ndi okwera mtengo. ”

Valery, 52, Kazan, "Adalemba mankhwala a shuga. Kukhutitsidwa ndi zomwe achitazo. Magazi a m'magazi anabwezera mwachangu. Koma sindinathe kumwa kwa nthawi yayitali, chifukwa mtengo wa mankhwalawo ndiwokwera kwambiri. Zotsatira zoyipa zambiri. Panali kugona nthawi zonse, kusakwiya. Mutu umapweteka nthawi zonse, panali matenda otsegula m'mimba. Dokotalayo akuti ndi mankhwala osankhira, ndipo adandiwuza kuti ndithane ndi mankhwala ena. ”

Yuri, wazaka 48, Saratov: “Mankhwalawo afika. Kukhutitsidwa ndi zomwe achitazo. Anachepa thupi bwino, koma samatha kupitilira muyeso. Mankhwalawa adathandizira ndi vutoli. Mkhalidwe wa mtima wamtima nawonso watukuka. Zotsatira zoyipa, panali ma m'mimba komanso chizungulire chochepa. Koma zonse sizinachitike popanda chithandizo chamankhwala mosafunikira. ”

Madokotala amafufuza

Alexander, endocrinologist, ku Moscow: “Anthu amakonda kupatsidwa mankhwala othandizira odwala matenda amtundu wachiwiri wa shuga. Ndemanga ndizosiyana. Mtengo wa mapiritsiwo ndiwokwera. Ichi ndi chimodzi mwazabwino kwambiri. Odwala ambiri, zimachitika zosagwirizana, pomwe ena amadzichitira okha, pomwe ena amafunikira kusintha kwa mankhwalawo kapena kusiyiratu mankhwala. Chifukwa chake, ndimakayikira za Combogliz Prolong. Koma mankhwalawo ndi a mtengo wake. ”

Yaroslav, endocrinologist, St. Petersburg: "Ndakhala ndikugwiritsa ntchito mankhwalawa kwa nthawi yayitali kuti ndikhazikitse shuga wamba mwa odwala matenda a shuga a 2. Pali odwala ambiri omwe sakhutira. Choyamba, anthu ali ndi zotsatira zoyipa zingapo, zomwe ndi zovuta kale. Mwa odwala ena, zizindikiro za kuledzera zimanenedwa kotero kuti mwina mankhwala othandizira kapena kuchiritsa matenda amafunika.

Palinso odwala omwe mankhwalawo amawathandiza bwino. Mlingo wawo wa shuga ndi kulemera kwawo umasungidwa nthawi yayitali kwa nthawi yayitali. Chifukwa chake, ndimapereka mankhwala kwa odwala monga mankhwala osankha. ”

Mankhwala

Combogliz Prolong ndi mankhwala ochepetsa shuga a kalasi ya biguanide, yomwe imakhala ndi zinthu monga metformin ndi saxagliptin monohydrate, yomwe imathandizira kutsitsa shuga m'magazi. Mankhwalawa amagwiritsidwa ntchito pochiza matenda a shuga a degree yachiwiri mwa ana a zaka zosaposa khumi, komanso odwala akulu omwe zaka zawo siziposa 60. Mankhwala samalimbikitsidwa kwa amayi omwe ali ndi mwana, komanso amayi oyamwitsa kuti apewe chiopsezo chotenga ma pathologies mwa mwana.

Mankhwalawa amagwiritsidwa ntchito ngati monotherapy kapena mu zovuta kuchipatala. Njira yochizira, Mlingo, komanso nthawi ya maphunzirawa imatsimikiziridwa ndi dokotala atamufufuza, kutulutsa mayeso, kukhazikitsa chithunzi cholondola cha matendawa, poganizira mawonekedwe amunthu ndi msinkhu wa wodwalayo.

Zotsatira zamatenda a saxagliptin

Gawolo limathandizira kutsitsa seramu yamagazi ya wodwalayo. Imatha kuletsa ntchito ya dipeptidyl peptidase-4 zoletsa ndikuwonjezera ntchito ya glucagon-peptide-1 ndi gastroinhibitory polypeptide. Kuphatikiza apo, zinthu zimachulukitsa kuchuluka kwa glucagon-peptide-1 ndi polypeptide ya gastroinhibitory. Pambuyo kukhudzana ndi chigawochi, kuchuluka kwa shuga m'magazi kumachepetsedwa kwambiri. Kumwa mankhwalawa kumatha kuchepetsa mwayi wokhala ndi vuto la insulin.

Zotsatira zamatenda a metformin

Metformin, yomwe ndi gawo la mankhwalawa, ndiwothandizanso wodwala matenda ashuga. Imalimbana bwino ndi kuchuluka kwa glucose m'magazi a wodwala, osakhudza kutaya kwa m'mimba. Thupi limatha kulepheretsa kaphatikizidwe ka glucose pazinthu zopanda mafuta mu chiwindi. Gawo limatsitsa kuchuluka kwa shuga m'magazi mutatha kudya kapena kudya. Chifukwa cha zomwe zigawozi zimapangidwa, glucose amayamba kulumikizidwa bwino ndi thupi ndipo kagayidwe kabwino kamachitika mthupi. Kutenga mankhwalawa sikumapangitsa odwala omwe ali ndi vuto la kuchepa kwa insulin m'thupi, kutsika kwa shuga m'magazi pofika muyeso wokhazikitsidwa, komwe kumatha kupangitsa kuti njala ilowe mthupi.

Ubwino pochiza ndi Combogliz Kutalika: